Share This:
https://ntp.niehs.nih.gov/go/2884

TR 351 Rat Pathology Tables

NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11 
LAB: Battelle Columbus                                         DATE: 09/03/94   
EXP: 05020                   PARA-CHLOROANILINE                TIME: 18:21:54   
TEST: 01              CAGES FROM 0000 TO LAST CAGE             PAGE:   1        
TEST TYPE: CHRONIC          ROUTE: GAVAGE                      NTP C#: 02039B   
CONT: NO1CP9565302                                             CAS: 000106478   
PATHOLOGIST: J. TOFT                         S. EUSTIS                          
--------------------------------------------------------------------------------
                                                                                
                                                                                
                                                                                


REASONS FOR REMOVAL:                                                            
                                                                                
ALL                                                                             
                                                                                
                                                                                
REMOVAL DATE RANGE:                                                             


ALL                                                                             
                                                                                
TREATMENT GROUPS:                                                               
                                                                                
INCLUDE ALL                                                                     

NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11
LAB: Battelle Columbus                                         DATE: 09/03/94  
EXP: 05020                   PARA-CHLOROANILINE                TIME: 18:21:54  
TEST: 01              CAGES FROM 0000 TO LAST CAGE                             
TEST TYPE: CHRONIC          ROUTE: GAVAGE                      NTP C#: 02039B  
CONT: NO1CP9565302                                             CAS: 000106478  
PATHOLOGIST: J. TOFT                         S. EUSTIS                         

                                PARA-CHLOROANILINE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE RATS
                       FIRST TERMINAL SACRIFICE AT 729 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = VEHICLE                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 49     UNCENSORED DEATHS 31     CENSORED DEATHS 0    TERMINAL 18        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      72    263   330   455   466   512   521   554   568   578                 |
 |      584   626   627   628   633   633   639   647   655   655                 |
 |      662   674   680   688   688   701   704   709   710   721                 |
 |      723                                                                       |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 2 MG/KG                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 18     CENSORED DEATHS 0    TERMINAL 32        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      486   529   556   626   627   651   651   651   654   654                 |
 |      654   673   674   687   693   714   715   716                             |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 6 MG/KG                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 16     CENSORED DEATHS 2    TERMINAL 32        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      338   361   498   521   533   549   570   572   578   686                 |
 |      702   710   711   716   718   724                                         |
 |  CENSORED DEATHS                                                               |
 |      476   476                                                                 |
 |                                                                                |
 ==================================================================================

                                PARA-CHLOROANILINE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE RATS
                       FIRST TERMINAL SACRIFICE AT 729 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 18 MG/KG                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 28     CENSORED DEATHS 1    TERMINAL 21        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      415   494   522   535   556   584   615   618   622   624                 |
 |      654   659   659   674   676   679   680   686   686   689                 |
 |      700   712   716   721   722   728   728   728                             |
 |  CENSORED DEATHS                                                               |
 |      476                                                                       |
 |                                                                                |
 ==================================================================================

                                PARA-CHLOROANILINE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE RATS
                       FIRST TERMINAL SACRIFICE AT 729 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   729 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |VEHICLE    |    98.0  98.0  95.9  93.9  93.9  89.8  85.7  77.6  57.1  36.7      |
 |           |                                                                    |
 |           |                                                                    |
 |2 MG/KG    |   100.0 100.0 100.0 100.0 100.0 100.0  96.0  94.0  78.0  64.0      |
 |           |                                                                    |
 |           |                                                                    |
 |6 MG/KG    |   100.0 100.0 100.0  96.0  96.0  96.0  89.7  81.4  81.4  66.8      |
 |           |                                                                    |
 |           |                                                                    |
 |18 MG/KG   |   100.0 100.0 100.0 100.0  98.0  98.0  91.9  87.8  73.5  42.9      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                  DOSE                          |
 |                                                                                |
 |                                VEHICLE      2 MG/KG      6 MG/KG      18 MG/KG |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       36.7%        64.0%        66.8%        42.9%    |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=0.793      P=0.007N     P=0.005N     P=0.367N |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       590.5        645.1        592.9        645.8    |
 |NATURAL DEATHS (C)      |       (26.2)       (14.9)       (31.3)       (15.1)   |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       641.4        698.8        675.3        677.3    |
 |(STANDARD ERROR)        |       (19.1)       ( 7.8)       (14.5)       (11.0)   |
 |                        |                                                       |
 ==================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                                PARA-CHLOROANILINE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE RATS
                       FIRST TERMINAL SACRIFICE AT 729 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = VEHICLE                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 23     CENSORED DEATHS 0    TERMINAL 27        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      80    189   200   209   369   400   482   519   529   537                 |
 |      544   557   605   612   618   630   637   658   662   701                 |
 |      714   722   728                                                           |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 2 MG/KG                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 11     CENSORED DEATHS 0    TERMINAL 39        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      140   428   605   605   617   664   688   693   716   723                 |
 |      728                                                                       |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 6 MG/KG                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 14     CENSORED DEATHS 0    TERMINAL 36        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      332   520   539   553   574   581   594   605   626   629                 |
 |      657   701   711   721                                                     |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================

                                PARA-CHLOROANILINE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE RATS
                       FIRST TERMINAL SACRIFICE AT 729 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 18 MG/KG                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 13     CENSORED DEATHS 0    TERMINAL 37        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      511   526   529   552   577   595   616   619   644   665                 |
 |      688   705   708                                                           |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================

                                PARA-CHLOROANILINE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE RATS
                       FIRST TERMINAL SACRIFICE AT 729 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   729 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |VEHICLE    |    98.0  98.0  92.0  92.0  88.0  86.0  78.0  74.0  62.0  54.0      |
 |           |                                                                    |
 |           |                                                                    |
 |2 MG/KG    |   100.0  98.0  98.0  98.0  98.0  96.0  96.0  92.0  88.0  78.0      |
 |           |                                                                    |
 |           |                                                                    |
 |6 MG/KG    |   100.0 100.0 100.0  98.0  98.0  98.0  94.0  84.0  78.0  72.0      |
 |           |                                                                    |
 |           |                                                                    |
 |18 MG/KG   |   100.0 100.0 100.0 100.0 100.0 100.0  94.0  88.0  80.0  74.0      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                  DOSE                          |
 |                                                                                |
 |                                VEHICLE      2 MG/KG      6 MG/KG      18 MG/KG |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       54.0%        78.0%        72.0%        74.0%    |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=0.244N     P=0.011N     P=0.075N     P=0.043N |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       517.5        600.6        595.9        610.4    |
 |NATURAL DEATHS (C)      |       (39.5)       (52.8)       (26.4)       (19.1)   |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       631.7        700.8        691.7        698.2    |
 |(STANDARD ERROR)        |       (23.4)       (13.5)       (11.2)       ( 8.9)   |
 |                        |                                                       |
 ==================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                                                         PARA-CHLOROANILINE
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        VEHICLE          = 1
                                                        2 MG/KG          = 2
                                                        6 MG/KG          = 3
                                                        18 MG/KG         = 4

------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  100 + 1           1                                         3           4          2
      |             1                             1           3  3        4          24     2
      |                                           1          1   3              1     43   324  2          2
      |                                                                         1 1        3 3  4
   90 +                                                                           1      1   3 34   4      2  2
      |                                                                                  1 1   3  3 4    4
P     |                                                                                    1    1        44   22
E     |                                                                                         1 11      44        3
R  80 +                                                                                            11      4   4    3  3
C     |                                                                                             1      1   2 4 2   33
E     |                                                                                                            2 2
N     |                                                                                                    11    4 4    33
T  70 +                                                                                                              2  233
      |                                                                                                     11     44   223 3
S     |                                                                                                      11          2  2
U     |                                                                                                       11    44
R  60 +                                                                                                        1 1   44
V     |                                                                                                          1 1  4 4
I     |                                                                                                            11   44
V     |                                                                                                             11
A  50 +                                                                                                              1 1 44
L     |
      |                                                                                                                11
      |                                                                                                                   4 4
   40 +                                                                                                                 111
      |                                                                                                                   1 1
      |
      |
   30 +
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 15 obs hidden.

                                                         PARA-CHLOROANILINE
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        VEHICLE          = 1
                                                        2 MG/KG          = 2
                                                        6 MG/KG          = 3
                                                        18 MG/KG         = 4

----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
  100 + 1            1        2                              3                          4
      |
      |              1        2       1                      3              2           4  34
      |                               1 1                                   2              3 3          2
   95 +
      |                                 11                                                  43 3
      |                                  1                        1                            3  34    2 2
      |
   90 +                                                           1     1                         33  4   2      2
      |
      |                                                                 1           1              3  3  4       2   2
      |                                                                             1      1          3 344
P  85 +
E     |                                                                                    11           3 43 4       2   2
R     |                                                                                     11               4   4       22
C     |
E  80 +                                                                                      11            3   3 4   4
N     |
T     |                                                                                       1 1              3     4 3  2 2
      |                                                                                         1       1              33
S  75 +
U     |                                                                                                 11              33  4
R     |                                                                                                  11              3  3
V     |
I  70 +                                                                                                   11
V     |
A     |                                                                                                    11
L     |                                                                                                     1  1
   65 +
      |                                                                                                        1 1
      |                                                                                                          1     1
      |
   60 +                                                                                                                11
      |
      |                                                                                                                 1 1
      |
   55 +
      |                                                                                                                   1 1
      |
      |
   50 +
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 11 obs hidden.