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TR 354 Mouse Pathology Tables


                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                            DIMETHOXANE


NTP Experiment-Test: 05038-02                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 09/05/94
Route: GAVAGE                                                                                                     Time: 09:04:29




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  828-00-2

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05038-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            DIMETHOXANE                                        Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 09:04:29  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 MG/KG      250 MG/      500 MG/                                                
                                                                KG           KG                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          60           60           60                                                  
  Scheduled Sacrifice                                 10           10           10                                                  
  Early Deaths                                                                                                                      
    Moribund                                           7            5            9                                                  
    Dead                                               7            9            7                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                36           35           34                                                  
  Missing                                                           1                                                               
  Animals Examined Microscopically                    50           49           50                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (50)         (14)         (50)                                                
   Gallbladder                                        (44)         (6)          (45)                                                
   Intestine Large, Cecum                             (46)         (10)         (48)                                                
      Leiomyoma                                                                  1 (2%)                                             
   Intestine Small, Duodenum                          (46)         (8)          (45)                                                
      Polyp Adenomatous                                                          1 (2%)                                             
   Intestine Small, Jejunum                           (48)         (13)         (45)                                                
   Liver                                              (50)         (19)         (50)                                                
      Choriocarcinoma, Metastatic, Ovary                                         1 (2%)                                             
      Hemangioma                                                    1 (5%)                                                          
      Hemangiosarcoma                                  1 (2%)                                                                       
      Hepatocellular Carcinoma                         2 (4%)                    1 (2%)                                             
      Hepatocellular Carcinoma, Multiple                            2 (11%)                                                         
      Hepatocellular Adenoma                           7 (14%)      3 (16%)      4 (8%)                                             
      Histiocytic Sarcoma                              1 (2%)                                                                       
      Ito Cell Tumor NOS                                                         1 (2%)                                             
   Mesentery                                          (41)         (11)         (49)                                                
   Pancreas                                           (49)         (15)         (49)                                                
   Salivary Glands                                    (48)         (13)         (49)                                                
   Stomach, Forestomach                               (49)         (48)         (48)                                                
      Squamous Cell Papilloma                          3 (6%)       3 (6%)       1 (2%)                                             
   Stomach, Glandular                                 (49)         (12)         (48)                                                
      Adenoma                                                       1 (8%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   2                                                               
NTP Experiment-Test: 05038-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            DIMETHOXANE                                        Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 09:04:29  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 MG/KG      250 MG/      500 MG/                                                
                                                                KG           KG                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (14)         (50)                                                
      Histiocytic Sarcoma                              1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (14)         (50)                                                
      Capsule, Adenoma                                                           1 (2%)                                             
   Adrenal Gland, Medulla                             (49)         (14)         (50)                                                
      Pheochromocytoma Benign                          1 (2%)                    1 (2%)                                             
   Pituitary Gland                                    (47)         (19)         (45)                                                
      Pars Distalis, Adenoma                           6 (13%)      4 (21%)      6 (13%)                                            
   Thyroid Gland                                      (50)         (14)         (47)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (49)         (21)         (50)                                                
      Cystadenoma                                                   1 (5%)       1 (2%)                                             
      Granulosa-Theca Tumor Benign                     1 (2%)                                                                       
      Mixed Tumor Benign                                                         1 (2%)                                             
      Yolk Sac Carcinoma                                                         1 (2%)                                             
   Uterus                                             (50)         (43)         (50)                                                
      Histiocytic Sarcoma                                                        1 (2%)                                             
      Polyp Stromal                                    3 (6%)       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (14)         (50)                                                
      Hemangiosarcoma                                  1 (2%)                                                                       
      Femoral, Hemangiosarcoma                         1 (2%)                                                                       
      Femoral, Histiocytic Sarcoma                     1 (2%)                                                                       
   Lymph Node                                         (50)         (16)         (50)                                                
      Mediastinal, Alveolar/Bronchiolar Carcinoma,                                                                                  
           Metastatic, Lung                                                      1 (2%)                                             
      Mediastinal, Histiocytic Sarcoma                 1 (2%)                                                                       
      Mediastinal, Osteosarcoma, Metastatic, Skin                   1 (6%)                                                          
      Mediastinal, Mesenteric, Fibrosarcoma,                                                                                        
          Metastatic, Skin                                                       1 (2%)                                             
   Lymph Node, Mandibular                             (48)         (13)         (49)                                                
                                                             Page   3                                                               
NTP Experiment-Test: 05038-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            DIMETHOXANE                                        Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 09:04:29  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 MG/KG      250 MG/      500 MG/                                                
                                                                KG           KG                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - cont                                                                                                         
   Spleen                                             (50)         (23)         (50)                                                
      Hemangiosarcoma                                  1 (2%)       1 (4%)                                                          
      Histiocytic Sarcoma                              1 (2%)                                                                       
   Thymus                                             (31)         (9)          (31)                                                
      Histiocytic Sarcoma                              1 (3%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (44)         (10)         (40)                                                
      Adenocarcinoma                                   1 (2%)                    2 (5%)                                             
      Adenoma                                                                    1 (3%)                                             
   Skin                                               (50)         (14)         (49)                                                
      Basosquamous Tumor Malignant                                               1 (2%)                                             
      Subcutaneous Tissue, Fibrosarcoma                1 (2%)       3 (21%)      2 (4%)                                             
      Subcutaneous Tissue, Osteosarcoma,                                                                                            
          Metastatic, Bone                                          1 (7%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (14)         (50)                                                
      Osteosarcoma                                                  1 (7%)                                                          
   Skeletal Muscle                                    (50)         (13)         (50)                                                
      Fibrosarcoma, Metastatic, Skin                                1 (8%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (14)         (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (14)         (50)                                                
      Alveolar/Bronchiolar Adenoma                     3 (6%)       1 (7%)       3 (6%)                                             
      Alveolar/Bronchiolar Adenoma, Multiple                                     1 (2%)                                             
      Alveolar/Bronchiolar Carcinoma                   1 (2%)                    1 (2%)                                             
      Basosquamous Tumor Malignant, Metastatic,                                                                                     
           Skin                                                                  1 (2%)                                             
      Choriocarcinoma, Metastatic, Ovary                                         1 (2%)                                             
      Histiocytic Sarcoma                              1 (2%)                                                                       
      Osteosarcoma, Metastatic, Bone                                1 (7%)                                                          
      Mediastinum, Alveolar/Bronchiolar Carcinoma                                1 (2%)                                             
   Nose                                               (50)         (14)         (50)                                                
   Trachea                                            (49)         (14)         (50)                                                
____________________________________________________________________________________________________________________________________
                                                             Page   4                                                               
NTP Experiment-Test: 05038-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            DIMETHOXANE                                        Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 09:04:29  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 MG/KG      250 MG/      500 MG/                                                
                                                                KG           KG                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (48)         (11)         (50)                                                
      Adenoma                                          2 (4%)                    1 (2%)                                             
      Carcinoma                                                                  1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (14)         (50)                                                
   Urinary Bladder                                    (49)         (12)         (49)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(49)        *(50)                                                
      Histiocytic Sarcoma                              1 (2%)                    1 (2%)                                             
      Lymphoma Malignant                                                         2 (4%)                                             
      Lymphoma Malignant Histiocytic                  10 (20%)      3 (6%)       5 (10%)                                            
      Lymphoma Malignant Lymphocytic                   4 (8%)       6 (12%)      5 (10%)                                            
      Lymphoma Malignant Mixed                                      3 (6%)       6 (12%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   5                                                               
NTP Experiment-Test: 05038-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            DIMETHOXANE                                        Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 09:04:29  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 MG/KG      250 MG/      500 MG/                                                
                                                                KG           KG                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            32          26          33                                                   
     Total Primary Neoplasms                           50          34          53                                                   
                                                                                                                                    
   Total Animals with Benign Neoplasms                 20          13          17                                                   
     Total Benign Neoplasms                            26          15          23                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms              18          18          22                                                   
     Total Malignant Neoplasms                         24          19          29                                                   
                                                                                                                                    
   Total Animals with Metastatic Neoplasms                          2           4                                                   
     Total Metastatic Neoplasm                                      4           5                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                          1                                                   
     Total Uncertain Neoplasms                                                  1                                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   6                                                               
NTP Experiment-Test: 05038-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            DIMETHOXANE                                        Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 09:04:29  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 MG/KG      250 MG/      500 MG/                                                
                                                                KG           KG                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          60           60           60                                                  
  Scheduled Sacrifice                                 10           10           10                                                  
  Early Deaths                                                                                                                      
    Moribund                                           6           11            9                                                  
    Dead                                              11           10           12                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                33           27           29                                                  
  Wrong Sex                                                         2                                                               
  Animals Examined Microscopically                    50           48           50                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (49)         (21)         (50)                                                
      Adenocarcinoma, Metastatic, Uncertain                                                                                         
          Primary Site                                 1 (2%)                                                                       
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                  1 (2%)                                             
      Fibrosarcoma, Metastatic, Skin                                1 (5%)                                                          
      Squamous Cell Papilloma                                       1 (5%)                                                          
   Intestine Small, Ileum                             (44)         (16)         (44)                                                
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                  1 (2%)                                             
   Intestine Small, Jejunum                           (47)         (19)         (44)                                                
   Liver                                              (49)         (28)         (50)                                                
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                  1 (2%)                                             
      Cholangiocarcinoma                               1 (2%)                                                                       
      Fibrosarcoma, Metastatic, Skin                                1 (4%)                                                          
      Hemangiosarcoma                                               1 (4%)       1 (2%)                                             
      Hemangiosarcoma, Multiple                        3 (6%)                    1 (2%)                                             
      Hepatocellular Carcinoma                         9 (18%)      8 (29%)      6 (12%)                                            
      Hepatocellular Carcinoma, Multiple                            2 (7%)                                                          
      Hepatocellular Adenoma                           6 (12%)      5 (18%)     11 (22%)                                            
      Hepatocellular Adenoma, Multiple                 1 (2%)                    2 (4%)                                             
      Sarcoma                                          1 (2%)                                                                       
      Squamous Cell Carcinoma, Metastatic, Stomach                               1 (2%)                                             
   Mesentery                                          (41)         (19)         (48)                                                
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                  1 (2%)                                             
      Carcinosarcoma, Metastatic, Uncertain                                                                                         
          Primary Site                                 1 (2%)                                                                       
      Fibrosarcoma, Metastatic, Skin                                1 (5%)                                                          
                                                             Page   7                                                               
NTP Experiment-Test: 05038-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            DIMETHOXANE                                        Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 09:04:29  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 MG/KG      250 MG/      500 MG/                                                
                                                                KG           KG                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - cont                                                                                                            
      Hemangiosarcoma                                                            1 (2%)                                             
      Squamous Cell Carcinoma, Metastatic, Stomach                               1 (2%)                                             
   Pancreas                                           (48)         (20)         (49)                                                
      Adenocarcinoma, Metastatic, Uncertain                                                                                         
          Primary Site                                 1 (2%)                                                                       
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                  1 (2%)                                             
      Squamous Cell Carcinoma, Metastatic, Stomach                               1 (2%)                                             
   Stomach, Forestomach                               (47)         (47)         (50)                                                
      Squamous Cell Carcinoma                                                    1 (2%)                                             
      Squamous Cell Papilloma                          1 (2%)       3 (6%)       7 (14%)                                            
      Squamous Cell Papilloma, Multiple                1 (2%)                                                                       
   Stomach, Glandular                                 (47)         (20)         (50)                                                
      Adenocarcinoma                                   1 (2%)                                                                       
      Squamous Cell Carcinoma                                                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (49)         (21)         (50)                                                
      Adenocarcinoma, Metastatic, Uncertain                                                                                         
          Primary Site                                 1 (2%)                                                                       
      Carcinosarcoma, Metastatic, Uncertain                                                                                         
          Primary Site                                 1 (2%)                                                                       
      Sarcoma, Metastatic, Uncertain Primary Site      1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (21)         (50)                                                
      Adenocarcinoma, Metastatic, Uncertain                                                                                         
          Primary Site                                 1 (2%)                                                                       
      Adenoma                                          1 (2%)                                                                       
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                  1 (2%)                                             
      Capsule, Adenoma                                 5 (10%)                   3 (6%)                                             
   Adrenal Gland, Medulla                             (50)         (21)         (50)                                                
      Pheochromocytoma Benign                          2 (4%)                                                                       
   Islets, Pancreatic                                 (48)         (19)         (49)                                                
      Adenoma                                          1 (2%)                                                                       
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                  1 (2%)                                             
   Pituitary Gland                                    (46)         (20)         (41)                                                
      Pars Distalis, Carcinoma                                      1 (5%)                                                          
   Thyroid Gland                                      (49)         (22)         (50)                                                
      Follicular Cell, Adenoma                         1 (2%)       1 (5%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                             Page   8                                                               
NTP Experiment-Test: 05038-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            DIMETHOXANE                                        Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 09:04:29  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 MG/KG      250 MG/      500 MG/                                                
                                                                KG           KG                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Coagulating Gland                                  (45)         (20)         (49)                                                
      Squamous Cell Carcinoma, Metastatic, Stomach                               1 (2%)                                             
   Epididymis                                         (50)         (21)         (47)                                                
      Fibrosarcoma, Metastatic, Skin                                1 (5%)                                                          
      Squamous Cell Carcinoma, Metastatic, Stomach                               1 (2%)                                             
   Prostate                                           (48)         (21)         (49)                                                
      Squamous Cell Carcinoma, Metastatic, Stomach                               1 (2%)                                             
   Seminal Vesicle                                    (43)         (20)         (46)                                                
      Fibrosarcoma, Metastatic, Skin                                1 (5%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (21)         (50)                                                
      Femoral, Hemangiosarcoma                         1 (2%)                    1 (2%)                                             
   Lymph Node                                         (50)         (24)         (49)                                                
      Axillary, Fibrosarcoma, Metastatic, Skin                      1 (4%)                                                          
      Bronchial, Alveolar/Bronchiolar Carcinoma,                                                                                    
           Metastatic, Lung                                                      1 (2%)                                             
      Inguinal, Fibrosarcoma, Metastatic, Skin                      1 (4%)                                                          
      Mediastinal, Sarcoma, Metastatic, Uncertain                                                                                   
          Primary Site                                 1 (2%)                                                                       
   Lymph Node, Mandibular                             (48)         (20)         (49)                                                
      Adenocarcinoma, Metastatic, Uncertain                                                                                         
          Primary Site                                 1 (2%)                                                                       
   Spleen                                             (49)         (26)         (50)                                                
      Adenocarcinoma, Metastatic, Uncertain                                                                                         
          Primary Site                                 1 (2%)                                                                       
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                  1 (2%)                                             
      Fibrosarcoma, Metastatic, Skin                                1 (4%)                                                          
      Hemangioma                                                                 2 (4%)                                             
      Hemangiosarcoma                                  1 (2%)       1 (4%)       1 (2%)                                             
      Squamous Cell Carcinoma, Metastatic, Stomach                               1 (2%)                                             
   Thymus                                             (27)         (12)         (24)                                                
      Sarcoma, Metastatic, Uncertain Primary Site      1 (4%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   9                                                               
NTP Experiment-Test: 05038-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            DIMETHOXANE                                        Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 09:04:29  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 MG/KG      250 MG/      500 MG/                                                
                                                                KG           KG                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (50)         (33)         (49)                                                
      Subcutaneous Tissue, Fibroma                     2 (4%)                    4 (8%)                                             
      Subcutaneous Tissue, Fibrosarcoma                8 (16%)      9 (27%)      5 (10%)                                            
      Subcutaneous Tissue, Fibrosarcoma, Multiple      2 (4%)       1 (3%)                                                          
      Subcutaneous Tissue, Hemangiosarcoma                          1 (3%)       1 (2%)                                             
      Subcutaneous Tissue, Sarcoma                                               1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                    (49)         (21)         (49)                                                
      Fibrosarcoma, Metastatic, Skin                                3 (14%)                                                         
      Diaphragm, Squamous Cell Carcinoma,                                                                                           
          Metastatic, Stomach                                                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (49)         (25)         (50)                                                
      Adenocarcinoma, Metastatic, Uncertain                                                                                         
          Primary Site                                 1 (2%)                                                                       
      Alveolar/Bronchiolar Adenoma                     8 (16%)      2 (8%)       8 (16%)                                            
      Alveolar/Bronchiolar Adenoma, Multiple                                     1 (2%)                                             
      Alveolar/Bronchiolar Carcinoma                                2 (8%)       4 (8%)                                             
      Carcinosarcoma, Metastatic, Uncertain                                                                                         
          Primary Site                                 1 (2%)                                                                       
      Fibrosarcoma, Metastatic, Skin                                1 (4%)                                                          
      Hepatocellular Carcinoma, Metastatic, Liver      3 (6%)       3 (12%)      1 (2%)                                             
      Sarcoma, Metastatic, Uncertain Primary Site      1 (2%)                                                                       
      Squamous Cell Carcinoma, Metastatic, Stomach                               1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (48)         (25)         (48)                                                
      Adenoma                                          2 (4%)       2 (8%)       2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page  10                                                               
NTP Experiment-Test: 05038-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            DIMETHOXANE                                        Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 09:04:29  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 MG/KG      250 MG/      500 MG/                                                
                                                                KG           KG                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (23)         (50)                                                
      Adenocarcinoma, Metastatic, Uncertain                                                                                         
          Primary Site                                 1 (2%)                                                                       
      Adenoma                                          1 (2%)                                                                       
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                  2 (4%)                                             
      Fibrosarcoma, Metastatic, Skin                                1 (4%)                                                          
      Squamous Cell Carcinoma, Metastatic, Stomach                               1 (2%)                                             
   Urethra                                            (23)         (15)         (29)                                                
      Transitional Epithelium, Carcinoma                            1 (7%)                                                          
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(48)        *(50)                                                
      Lymphoma Malignant                               1 (2%)                                                                       
      Lymphoma Malignant Histiocytic                   4 (8%)       1 (2%)       3 (6%)                                             
      Lymphoma Malignant Lymphocytic                   2 (4%)       1 (2%)                                                          
      Lymphoma Malignant Mixed                         2 (4%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  11                                                               
NTP Experiment-Test: 05038-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            DIMETHOXANE                                        Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 09:04:29  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 MG/KG      250 MG/      500 MG/                                                
                                                                KG           KG                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            38          31          37                                                   
     Total Primary Neoplasms                           68          43          68                                                   
                                                                                                                                    
   Total Animals with Benign Neoplasms                 18          13          26                                                   
     Total Benign Neoplasms                            32          14          41                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms              29          26          18                                                   
     Total Malignant Neoplasms                         36          29          27                                                   
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              6           7           3                                                   
     Total Metastatic Neoplasm                         18          16          22                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms               3                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  12                                                               
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