National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/3434

TR 354 Rat Pathology Tables


                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                                            DIMETHOXANE


NTP Experiment-Test: 05038-01                                                                                     Report: PEIRPT03
Study Type: CHRONIC                                                                                               Date: 09/05/94
Route: GAVAGE                                                                                                     Time: 07:33:28




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  828-00-2

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05038-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            DIMETHOXANE                                        Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 07:33:28  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0 MG/KG      125 MG/      250 MG/                                                
                                                                KG           KG                                                     
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          60           60           60                                                  
  Scheduled Sacrifice                                 10           10           10                                                  
  Early Deaths                                                                                                                      
    Moribund                                          12           13           13                                                  
    Dead                                               6            3            2                                                  
    Dosing Accident                                    2            3           11                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                30           31           24                                                  
  Animals Examined Microscopically                    50           50           50                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (50)         (50)         (50)                                                
      Foreign Body                                     1 (2%)                                                                       
      Hemorrhage, Acute                                1 (2%)                    1 (2%)                                             
      Inflammation, Chronic Active                     1 (2%)                    3 (6%)                                             
      Perforation                                                                1 (2%)                                             
   Intestine Large, Cecum                             (44)         (47)         (45)                                                
      Concretion                                                                 1 (2%)                                             
      Inflammation, Chronic Active                                               1 (2%)                                             
      Parasite Metazoan                                             1 (2%)       1 (2%)                                             
   Intestine Large, Colon                             (48)         (50)         (50)                                                
      Diverticulum                                     1 (2%)                                                                       
      Parasite Metazoan                                             1 (2%)       4 (8%)                                             
   Intestine Large, Rectum                            (47)         (47)         (46)                                                
      Parasite Metazoan                                4 (9%)       4 (9%)       2 (4%)                                             
   Liver                                              (50)         (49)         (50)                                                
      Basophilic Focus                                40 (80%)     35 (71%)     34 (68%)                                            
      Clear Cell Focus                                 3 (6%)       3 (6%)       3 (6%)                                             
      Degeneration, Cystic                                          1 (2%)                                                          
      Eosinophilic Focus                                                         1 (2%)                                             
      Hematopoietic Cell Proliferation                                           1 (2%)                                             
      Hepatodiaphragmatic Nodule                       6 (12%)                   4 (8%)                                             
      Inflammation, Chronic                           23 (46%)     18 (37%)     21 (42%)                                            
      Inflammation, Necrotizing                                                  1 (2%)                                             
      Necrosis, Coagulative                            1 (2%)                                                                       
      Vacuolization Cytoplasmic                                     2 (4%)                                                          
   Mesentery                                          (47)         (46)         (49)                                                
      Inflammation, Chronic Active                     2 (4%)       1 (2%)       1 (2%)                                             
      Mineralization                                   1 (2%)                                                                       
   Pancreas                                           (50)         (50)         (50)                                                
      Acinus, Atrophy                                 14 (28%)     19 (38%)     12 (24%)                                            
   Salivary Glands                                    (48)         (50)         (49)                                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05038-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            DIMETHOXANE                                        Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 07:33:28  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0 MG/KG      125 MG/      250 MG/                                                
                                                                KG           KG                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Inflammation, Chronic Active                     1 (2%)                                                                       
      Acinus, Atrophy                                  1 (2%)                                                                       
      Duct, Hyperplasia                                1 (2%)                                                                       
   Stomach, Forestomach                               (50)         (50)         (50)                                                
      Acanthosis, Diffuse                                                        3 (6%)                                             
      Acanthosis, Focal                                             8 (16%)     41 (82%)                                            
      Hyperkeratosis, Diffuse                                                   10 (20%)                                            
      Hyperkeratosis, Focal                                         5 (10%)     12 (24%)                                            
      Hyperplasia, Focal                                            1 (2%)       3 (6%)                                             
      Inflammation, Chronic Active                     1 (2%)       3 (6%)                                                          
      Ulcer                                                         3 (6%)                                                          
   Stomach, Glandular                                 (50)         (49)         (50)                                                
      Inflammation, Chronic Active                     1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (49)         (50)         (50)                                                
      Inflammation, Chronic Active                                               1 (2%)                                             
   Heart                                              (50)         (50)         (50)                                                
      Bacterium, Multiple                                           1 (2%)       1 (2%)                                             
      Cardiomyopathy, Chronic                         37 (74%)     33 (66%)     32 (64%)                                            
      Foreign Body                                                  1 (2%)       2 (4%)                                             
      Infarct                                                       1 (2%)                                                          
      Inflammation, Chronic Active                                  3 (6%)       6 (12%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (50)         (50)                                                
      Degeneration, Fatty                              3 (6%)      13 (26%)      7 (14%)                                            
      Hyperplasia                                     17 (34%)     20 (40%)     18 (36%)                                            
      Hypertrophy                                      1 (2%)                    1 (2%)                                             
      Necrosis, Coagulative                                         1 (2%)       4 (8%)                                             
   Adrenal Gland, Medulla                             (50)         (50)         (49)                                                
      Hyperplasia                                      5 (10%)      5 (10%)      8 (16%)                                            
   Parathyroid Gland                                  (46)         (43)         (42)                                                
      Cyst                                                          1 (2%)                                                          
      Hyperplasia                                                   2 (5%)                                                          
   Pituitary Gland                                    (48)         (49)         (50)                                                
      Pars Distalis, Cyst                             19 (40%)     21 (43%)     28 (56%)                                            
      Pars Distalis, Hemorrhage, Acute                 1 (2%)                                                                       
      Pars Distalis, Hyperplasia                      20 (42%)     18 (37%)     15 (30%)                                            
      Pars Distalis, Pigmentation, Hemosiderin                                   4 (8%)                                             
      Pars Intermedia, Cyst                                         1 (2%)                                                          
   Thyroid Gland                                      (50)         (50)         (50)                                                
      Hemorrhage, Chronic                                                        1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05038-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            DIMETHOXANE                                        Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 07:33:28  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0 MG/KG      125 MG/      250 MG/                                                
                                                                KG           KG                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Inflammation, Chronic Active                                               2 (4%)                                             
      C-Cell, Hyperplasia                             26 (52%)     24 (48%)     27 (54%)                                            
      Follicle, Cyst                                                1 (2%)                                                          
      Follicular Cell, Hyperplasia                                  1 (2%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (47)         (46)         (48)                                                
      Fibrosis                                                                   1 (2%)                                             
      Hyperplasia                                      5 (11%)      7 (15%)      2 (4%)                                             
      Inflammation, Chronic Active                     1 (2%)       3 (7%)       7 (15%)                                            
      Necrosis, Caseous                                             2 (4%)                                                          
      Duct, Dilatation                                              2 (4%)                                                          
   Ovary                                              (50)         (49)         (50)                                                
      Atrophy                                                       3 (6%)       1 (2%)                                             
      Cyst                                             3 (6%)       4 (8%)       2 (4%)                                             
   Uterus                                             (50)         (49)         (50)                                                
      Dilatation                                       5 (10%)      5 (10%)      2 (4%)                                             
      Diverticulum                                                               1 (2%)                                             
      Hemorrhage                                       2 (4%)       1 (2%)                                                          
      Inflammation, Chronic Active                                               3 (6%)                                             
      Prolapse                                         1 (2%)                                                                       
      Endometrium, Hyperplasia, Cystic, Glandular      2 (4%)       6 (12%)      8 (16%)                                            
   Vagina                                             (2)                       (1)                                                 
      Inflammation, Chronic Active                                               1 (100%)                                           
      Prolapse                                         1 (50%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)                                                
      Femoral, Hyperplasia, Reticulum Cell             5 (10%)      1 (2%)       2 (4%)                                             
   Lymph Node                                         (50)         (50)         (50)                                                
      Inguinal, Cyst                                   1 (2%)                                                                       
      Mediastinal, Hyperplasia, Lymphoid                                         1 (2%)                                             
      Mediastinal, Hyperplasia, Plasma Cell                                      1 (2%)                                             
      Mediastinal, Inflammation, Chronic Active                     1 (2%)                                                          
      Mediastinal, Lymphocyte, Necrosis, Acute                                   1 (2%)                                             
      Mesenteric, Hemorrhage, Acute                                              1 (2%)                                             
      Pancreatic, Thrombosis                                        1 (2%)                                                          
   Spleen                                             (50)         (50)         (50)                                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05038-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            DIMETHOXANE                                        Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 07:33:28  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0 MG/KG      125 MG/      250 MG/                                                
                                                                KG           KG                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Fibrosis                                         1 (2%)                                                                       
      Hematopoietic Cell Proliferation                 3 (6%)       3 (6%)       4 (8%)                                             
      Hyperplasia, Lymphoid                                                      1 (2%)                                             
      Hyperplasia, Reticulum Cell                                                1 (2%)                                             
      Infarct, Chronic                                              1 (2%)                                                          
   Thymus                                             (41)         (38)         (41)                                                
      Cyst                                             3 (7%)                    2 (5%)                                             
      Hyperplasia, Lymphoid                                                      1 (2%)                                             
      Necrosis                                                      1 (3%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (47)         (50)         (47)                                                
      Cyst                                                          2 (4%)                                                          
      Hyperplasia, Cystic                             47 (100%)    49 (98%)     43 (91%)                                            
   Skin                                               (50)         (50)         (50)                                                
      Acanthosis                                                    1 (2%)                                                          
      Cyst Epithelial Inclusion                                                  1 (2%)                                             
      Edema                                                                      1 (2%)                                             
      Hyperkeratosis                                                1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (49)         (50)                                                
      Compression                                      5 (10%)      8 (16%)      4 (8%)                                             
      Hemorrhage, Acute                                3 (6%)       2 (4%)       2 (4%)                                             
      Hydrocephalus                                    1 (2%)       9 (18%)      4 (8%)                                             
      Pigmentation, Hemosiderin                                                  1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)                                                
      Bacterium                                                                  1 (2%)                                             
      Foreign Body                                     2 (4%)       4 (8%)       6 (12%)                                            
      Inflammation, Chronic                           12 (24%)     11 (22%)     11 (22%)                                            
      Alveolar Epithelium, Hyperplasia                 3 (6%)                    2 (4%)                                             
      Mediastinum, Bacterium, Multiple                              1 (2%)       1 (2%)                                             
      Mediastinum, Foreign Body                                                  1 (2%)                                             
      Mediastinum, Hemorrhage, Acute                                             3 (6%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05038-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            DIMETHOXANE                                        Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 07:33:28  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0 MG/KG      125 MG/      250 MG/                                                
                                                                KG           KG                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Mediastinum, Inflammation, Chronic Active                     1 (2%)       7 (14%)                                            
      Pleura, Hyperplasia                                                        1 (2%)                                             
   Nose                                               (50)         (50)         (50)                                                
      Foreign Body                                     1 (2%)       7 (14%)      1 (2%)                                             
      Inflammation, Chronic Active                     1 (2%)       5 (10%)      3 (6%)                                             
      Nasolacrimal Duct, Inflammation, Suppurative     2 (4%)       3 (6%)       2 (4%)                                             
   Trachea                                            (50)         (50)         (50)                                                
      Foreign Body                                                               1 (2%)                                             
      Hemorrhage, Acute                                                          1 (2%)                                             
      Inflammation, Chronic Active                                               1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (2)          (2)          (4)                                                 
      Hemorrhage, Acute                                1 (50%)                                                                      
      Lens, Cataract                                   1 (50%)      2 (100%)     2 (50%)                                            
      Retina, Atrophy                                  1 (50%)      2 (100%)     2 (50%)                                            
   Harderian Gland                                    (49)         (49)         (49)                                                
      Atrophy                                                       1 (2%)                                                          
      Inflammation, Chronic Active                                               1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)                                                
      Cyst                                             1 (2%)                    1 (2%)                                             
      Infarct, Chronic                                 1 (2%)                    1 (2%)                                             
      Mineralization                                   3 (6%)       2 (4%)       1 (2%)                                             
      Nephropathy, Chronic                            38 (76%)     35 (70%)     26 (52%)                                            
   Urinary Bladder                                    (49)         (48)         (48)                                                
      Dilatation                                                                 1 (2%)                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05038-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            DIMETHOXANE                                        Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 07:33:28  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0 MG/KG      62.5 MG/     125 MG/                                                
                                                                KG           KG                                                     
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          60           60           60                                                  
  Scheduled Sacrifice                                 10           10           10                                                  
  Early Deaths                                                                                                                      
    Moribund                                          21           15           12                                                  
    Dead                                               4            4            6                                                  
    Dosing Accident                                    2            3           11                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                23           28           21                                                  
  Animals Examined Microscopically                    50           50           50                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (49)         (50)         (50)                                                
      Hemorrhage, Acute                                             1 (2%)                                                          
      Inflammation, Chronic Active                                  2 (4%)       2 (4%)                                             
   Intestine Large, Colon                             (50)         (49)         (49)                                                
      Parasite Metazoan                                             3 (6%)       3 (6%)                                             
   Intestine Large, Rectum                            (49)         (47)         (47)                                                
      Parasite Metazoan                                6 (12%)      7 (15%)      3 (6%)                                             
   Intestine Small, Ileum                             (50)         (45)         (45)                                                
      Inflammation, Chronic Active                                               1 (2%)                                             
   Liver                                              (50)         (50)         (50)                                                
      Basophilic Focus                                24 (48%)     17 (34%)     18 (36%)                                            
      Clear Cell Focus                                 1 (2%)       2 (4%)                                                          
      Degeneration, Cystic                             2 (4%)       1 (2%)       3 (6%)                                             
      Hematopoietic Cell Proliferation                                           1 (2%)                                             
      Hepatodiaphragmatic Nodule                       2 (4%)       1 (2%)       2 (4%)                                             
      Hyperplasia, Nodular                                          1 (2%)                                                          
      Inflammation, Chronic                           11 (22%)      6 (12%)     13 (26%)                                            
      Inflammation, Necrotizing                        1 (2%)                    2 (4%)                                             
      Necrosis, Coagulative                            1 (2%)       1 (2%)       1 (2%)                                             
      Vacuolization Cytoplasmic                                     1 (2%)       2 (4%)                                             
   Mesentery                                          (49)         (49)         (46)                                                
      Hemorrhage, Chronic                                           1 (2%)       1 (2%)                                             
      Inflammation, Chronic Active                     4 (8%)      13 (27%)      9 (20%)                                            
      Mineralization                                                3 (6%)       5 (11%)                                            
      Necrosis                                                                   1 (2%)                                             
   Pancreas                                           (50)         (50)         (50)                                                
      Ectopic Tissue                                                             1 (2%)                                             
      Inflammation, Chronic Active                     2 (4%)                    1 (2%)                                             
      Acinus, Atrophy                                 18 (36%)     22 (44%)     21 (42%)                                            
      Acinus, Hyperplasia                                           2 (4%)       1 (2%)                                             
      Duct, Ectasia                                    1 (2%)       2 (4%)       1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 05038-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            DIMETHOXANE                                        Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 07:33:28  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0 MG/KG      62.5 MG/     125 MG/                                                
                                                                KG           KG                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
   Stomach, Forestomach                               (50)         (50)         (50)                                                
      Acanthosis, Focal                                5 (10%)      9 (18%)     23 (46%)                                            
      Edema                                            1 (2%)                                                                       
      Hyperkeratosis, Diffuse                                                    2 (4%)                                             
      Hyperkeratosis, Focal                            1 (2%)                    8 (16%)                                            
      Hyperplasia, Focal                               2 (4%)       1 (2%)       3 (6%)                                             
      Inflammation, Chronic                                         1 (2%)                                                          
      Inflammation, Chronic Active                     1 (2%)       1 (2%)                                                          
      Ulcer                                            1 (2%)                                                                       
   Stomach, Glandular                                 (50)         (49)         (50)                                                
      Inflammation, Chronic Active                     1 (2%)                                                                       
   Tooth                                              (50)         (49)         (50)                                                
      Dysplasia                                                     1 (2%)                                                          
      Inflammation, Chronic Active                     2 (4%)       1 (2%)       2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)                                                
      Cardiomyopathy, Chronic                         45 (90%)     48 (96%)     46 (92%)                                            
      Foreign Body                                                               2 (4%)                                             
      Inflammation, Chronic Active                                  2 (4%)       3 (6%)                                             
      Atrium, Thrombosis                               1 (2%)       5 (10%)      1 (2%)                                             
      Coronary Artery, Inflammation, Chronic Active                 1 (2%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (50)         (49)                                                
      Accessory Adrenal Cortical Nodule                1 (2%)                                                                       
      Atrophy                                                                    1 (2%)                                             
      Degeneration, Fatty                              5 (10%)      7 (14%)      7 (14%)                                            
      Hyperplasia                                     12 (24%)     19 (38%)     18 (37%)                                            
      Hypertrophy                                      1 (2%)       2 (4%)                                                          
      Necrosis, Coagulative                                                      1 (2%)                                             
   Adrenal Gland, Medulla                             (50)         (50)         (50)                                                
      Hyperplasia                                     13 (26%)     18 (36%)     13 (26%)                                            
   Islets, Pancreatic                                 (49)         (50)         (50)                                                
      Hyperplasia                                      1 (2%)                                                                       
   Pituitary Gland                                    (49)         (50)         (49)                                                
      Pars Distalis, Cyst                              6 (12%)      6 (12%)      9 (18%)                                            
      Pars Distalis, Hemorrhage, Acute                 1 (2%)                                                                       
      Pars Distalis, Hyperplasia                       9 (18%)      8 (16%)     11 (22%)                                            
      Pars Intermedia, Cyst                                                      1 (2%)                                             
   Thyroid Gland                                      (50)         (50)         (50)                                                
      Inflammation, Chronic Active                                               1 (2%)                                             
      C-Cell, Hyperplasia                             14 (28%)     16 (32%)     14 (28%)                                            
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
NTP Experiment-Test: 05038-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            DIMETHOXANE                                        Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 07:33:28  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0 MG/KG      62.5 MG/     125 MG/                                                
                                                                KG           KG                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Follicle, Cyst                                                1 (2%)                                                          
      Follicular Cell, Hyperplasia                     5 (10%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                                      (1)                                                              
      Hemorrhage, Acute                                             1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (48)         (50)         (50)                                                
      Inflammation, Chronic Active                     2 (4%)                                                                       
   Preputial Gland                                    (48)         (47)         (49)                                                
      Hyperplasia                                      2 (4%)       4 (9%)       1 (2%)                                             
      Inflammation, Chronic Active                    45 (94%)     43 (91%)     42 (86%)                                            
      Duct, Ectasia                                                              2 (4%)                                             
   Prostate                                           (50)         (50)         (50)                                                
      Cyst                                             1 (2%)       2 (4%)                                                          
      Inflammation, Chronic Active                    24 (48%)     23 (46%)     22 (44%)                                            
   Seminal Vesicle                                    (48)         (49)         (48)                                                
      Inflammation, Chronic Active                                               1 (2%)                                             
   Testes                                             (50)         (50)         (50)                                                
      Cyst                                             1 (2%)                                                                       
      Hemorrhage, Chronic                                                        1 (2%)                                             
      Inflammation, Chronic Active                                               1 (2%)                                             
      Mineralization                                   8 (16%)     16 (32%)      7 (14%)                                            
      Interstitial Cell, Hyperplasia                  27 (54%)     33 (66%)     33 (66%)                                            
      Seminiferous Tubule, Atrophy                    40 (80%)     38 (76%)     34 (68%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)                                                
      Femoral, Hyperplasia, Reticulum Cell             1 (2%)                    2 (4%)                                             
      Femoral, Myelofibrosis                           2 (4%)                                                                       
   Lymph Node                                         (50)         (50)         (50)                                                
      Mediastinal, Cyst                                                          1 (2%)                                             
      Mediastinal, Edema, Acute                                                  1 (2%)                                             
      Mediastinal, Hemorrhage, Acute                                             1 (2%)                                             
   Lymph Node, Mandibular                             (50)         (50)         (49)                                                
      Cyst                                                          6 (12%)      2 (4%)                                             
      Hyperplasia, Plasma Cell                                      1 (2%)                                                          
   Spleen                                             (50)         (50)         (50)                                                
      Fibrosis                                         3 (6%)       2 (4%)       2 (4%)                                             
      Hematopoietic Cell Proliferation                 1 (2%)       1 (2%)       3 (6%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    9                                                              
NTP Experiment-Test: 05038-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            DIMETHOXANE                                        Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 07:33:28  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0 MG/KG      62.5 MG/     125 MG/                                                
                                                                KG           KG                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Infarct, Chronic                                              1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (42)         (43)         (42)                                                
      Hyperplasia, Cystic                             38 (90%)     43 (100%)    39 (93%)                                            
      Inflammation, Chronic Active                                               1 (2%)                                             
   Skin                                               (50)         (50)         (50)                                                
      Acanthosis                                       1 (2%)       1 (2%)       1 (2%)                                             
      Fibrosis                                         1 (2%)                                                                       
      Hyperkeratosis                                   2 (4%)       3 (6%)       2 (4%)                                             
      Inflammation, Chronic Active                     3 (6%)       2 (4%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)                                                
      Compression                                      7 (14%)      3 (6%)       4 (8%)                                             
      Hemorrhage, Acute                                3 (6%)       1 (2%)       1 (2%)                                             
      Hydrocephalus                                    7 (14%)      3 (6%)       3 (6%)                                             
      Necrosis                                         1 (2%)                                                                       
   Spinal Cord                                                     (1)                                                              
      White Matter, Degeneration                                    1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)                                                
      Bacterium, Multiple                                                        1 (2%)                                             
      Foreign Body                                     2 (4%)       6 (12%)      9 (18%)                                            
      Inflammation, Chronic                           21 (42%)     11 (22%)     15 (30%)                                            
      Alveolar Epithelium, Hyperplasia                 4 (8%)       5 (10%)      3 (6%)                                             
      Mediastinum, Hemorrhage, Acute                                1 (2%)                                                          
      Mediastinum, Inflammation, Chronic Active                     2 (4%)       4 (8%)                                             
   Nose                                               (50)         (48)         (50)                                                
      Fibrosis                                                      1 (2%)                                                          
      Foreign Body                                                  9 (19%)                                                         
      Inflammation, Chronic Active                     2 (4%)       6 (13%)      1 (2%)                                             
      Nasolacrimal Duct, Inflammation, Chronic                                                                                      
          Active                                                    1 (2%)                                                          
      Nasolacrimal Duct, Inflammation, Suppurative     3 (6%)       3 (6%)       2 (4%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   10                                                              
NTP Experiment-Test: 05038-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            DIMETHOXANE                                        Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 07:33:28  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0 MG/KG      62.5 MG/     125 MG/                                                
                                                                KG           KG                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
   Trachea                                            (49)         (50)         (50)                                                
      Hemorrhage, Acute                                             1 (2%)                                                          
      Inflammation, Chronic Active                                  2 (4%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                                          (1)                                                 
      Acanthosis                                                                 1 (100%)                                           
      Hyperkeratosis                                                             1 (100%)                                           
   Eye                                                (3)          (2)          (5)                                                 
      Lens, Cataract                                   3 (100%)     1 (50%)      1 (20%)                                            
      Retina, Atrophy                                  3 (100%)     1 (50%)      1 (20%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)                                                
      Cyst                                                          1 (2%)       2 (4%)                                             
      Hemorrhage, Chronic                                           1 (2%)                                                          
      Infarct, Chronic                                                           1 (2%)                                             
      Inflammation, Necrotizing                        1 (2%)                                                                       
      Mineralization                                                             1 (2%)                                             
      Nephropathy, Chronic                            47 (94%)     49 (98%)     47 (94%)                                            
   Urinary Bladder                                    (49)         (49)         (49)                                                
      Dilatation                                       1 (2%)                                                                       
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   11                                                              
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NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.