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TR 354 Rat Pathology Tables


                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                            DIMETHOXANE


NTP Experiment-Test: 05038-01                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 09/05/94
Route: GAVAGE                                                                                                     Time: 07:33:29




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  828-00-2

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05038-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            DIMETHOXANE                                        Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 07:33:29  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 MG/KG      125 MG/      250 MG/                                                
                                                                KG           KG                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          60           60           60                                                  
  Scheduled Sacrifice                                 10           10           10                                                  
  Early Deaths                                                                                                                      
    Moribund                                          12           13           13                                                  
    Dead                                               6            3            2                                                  
    Dosing Accident                                    2            3           11                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                30           31           24                                                  
  Animals Examined Microscopically                    50           50           50                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (50)         (49)         (50)                                                
      Histiocytic Sarcoma                                                        1 (2%)                                             
      Neoplastic Nodule                                             1 (2%)       1 (2%)                                             
   Mesentery                                          (47)         (46)         (49)                                                
   Pancreas                                           (50)         (50)         (50)                                                
   Salivary Glands                                    (48)         (50)         (49)                                                
   Stomach, Forestomach                               (50)         (50)         (50)                                                
      Squamous Cell Papilloma, Multiple                                          1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (50)         (50)                                                
      Adenoma                                                       1 (2%)       2 (4%)                                             
      Bilateral, Adenoma                               1 (2%)                                                                       
      Medulla, Granulosa-Theca Tumor Malignant,                                                                                     
           Metastatic, Ovary                                                     1 (2%)                                             
   Adrenal Gland, Medulla                             (50)         (50)         (49)                                                
      Pheochromocytoma Benign                          2 (4%)                                                                       
   Islets, Pancreatic                                 (50)         (50)         (50)                                                
      Adenoma                                                                    1 (2%)                                             
   Pituitary Gland                                    (48)         (49)         (50)                                                
      Pars Distalis, Adenoma                          13 (27%)     13 (27%)      7 (14%)                                            
   Thyroid Gland                                      (50)         (50)         (50)                                                
      Bilateral, C-Cell, Adenoma                       1 (2%)       1 (2%)       1 (2%)                                             
                                                             Page   2                                                               
NTP Experiment-Test: 05038-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            DIMETHOXANE                                        Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 07:33:29  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 MG/KG      125 MG/      250 MG/                                                
                                                                KG           KG                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - cont                                                                                                             
      C-Cell, Adenoma                                 12 (24%)     11 (22%)      6 (12%)                                            
      C-Cell, Carcinoma                                2 (4%)       1 (2%)       1 (2%)                                             
      Follicular Cell, Carcinoma                       1 (2%)                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (47)         (46)         (48)                                                
      Adenoma                                          1 (2%)                                                                       
   Ovary                                              (50)         (49)         (50)                                                
      Granulosa-Theca Tumor Malignant                                            1 (2%)                                             
      Granulosa-Theca Tumor Benign                                               1 (2%)                                             
      Histiocytic Sarcoma                                                        1 (2%)                                             
   Uterus                                             (50)         (49)         (50)                                                
      Adenocarcinoma                                   1 (2%)                    1 (2%)                                             
      Polyp Stromal                                    5 (10%)      3 (6%)       2 (4%)                                             
      Polyp Stromal, Multiple                          1 (2%)                                                                       
      Sarcoma Stromal                                               2 (4%)                                                          
   Vagina                                             (2)                       (1)                                                 
      Polyp                                                                      1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)                                                
   Lymph Node                                         (50)         (50)         (50)                                                
   Lymph Node, Mandibular                             (47)         (50)         (49)                                                
   Spleen                                             (50)         (50)         (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (47)         (50)         (47)                                                
      Adenoma                                          2 (4%)                    1 (2%)                                             
      Fibroadenoma                                    12 (26%)     10 (20%)     10 (21%)                                            
      Fibroadenoma, Multiple                           2 (4%)       1 (2%)       3 (6%)                                             
   Skin                                               (50)         (50)         (50)                                                
      Basal Cell Carcinoma                                                       1 (2%)                                             
      Granulosa-Theca Tumor Malignant, Metastatic,                                                                                  
           Ovary                                                                 1 (2%)                                             
      Squamous Cell Carcinoma                                       1 (2%)                                                          
      Subcutaneous Tissue, Fibroma                     1 (2%)                                                                       
                                                             Page   3                                                               
NTP Experiment-Test: 05038-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            DIMETHOXANE                                        Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 07:33:29  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 MG/KG      125 MG/      250 MG/                                                
                                                                KG           KG                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - cont                                                                                                         
      Subcutaneous Tissue, Sarcoma                                  1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (49)         (50)                                                
      Astrocytoma Malignant                                         1 (2%)                                                          
      Histiocytic Sarcoma                                                        1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)                                                
      Basal Cell Carcinoma, Metastatic, Skin                                     1 (2%)                                             
      Granulosa-Theca Tumor Malignant, Metastatic,                                                                                  
           Ovary                                                                 1 (2%)                                             
      Histiocytic Sarcoma                                                        1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Zymbal's Gland                                     (1)                                                                           
      Carcinoma                                        1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)                                                
   Urinary Bladder                                    (49)         (48)         (48)                                                
      Papilloma                                        1 (2%)       1 (2%)                                                          
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)                                                
      Histiocytic Sarcoma                                                        1 (2%)                                             
      Leukemia Mononuclear                            12 (24%)     14 (28%)     12 (24%)                                            
      Lymphoma Malignant Histiocytic                                1 (2%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   4                                                               
NTP Experiment-Test: 05038-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            DIMETHOXANE                                        Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 07:33:29  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 MG/KG      125 MG/      250 MG/                                                
                                                                KG           KG                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            41          37          32                                                   
     Total Primary Neoplasms                           71          63          56                                                   
                                                                                                                                    
   Total Animals with Benign Neoplasms                 35          28          26                                                   
     Total Benign Neoplasms                            54          42          37                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms              14          20          16                                                   
     Total Malignant Neoplasms                         17          21          19                                                   
                                                                                                                                    
   Total Animals with Metastatic Neoplasms                                      2                                                   
     Total Metastatic Neoplasm                                                  4                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   5                                                               
NTP Experiment-Test: 05038-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            DIMETHOXANE                                        Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 07:33:29  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 MG/KG      62.5 MG/     125 MG/                                                
                                                                KG           KG                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          60           60           60                                                  
  Scheduled Sacrifice                                 10           10           10                                                  
  Early Deaths                                                                                                                      
    Moribund                                          21           15           12                                                  
    Dead                                               4            4            6                                                  
    Dosing Accident                                    2            3           11                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                23           28           21                                                  
  Animals Examined Microscopically                    50           50           50                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Rectum                            (49)         (47)         (47)                                                
   Intestine Small, Ileum                             (50)         (45)         (45)                                                
   Intestine Small, Jejunum                           (49)         (50)         (49)                                                
   Liver                                              (50)         (50)         (50)                                                
      Neoplastic Nodule                                             1 (2%)                                                          
   Mesentery                                          (49)         (49)         (46)                                                
   Pancreas                                           (50)         (50)         (50)                                                
      Acinus, Adenoma, Multiple                        1 (2%)                                                                       
   Salivary Glands                                    (50)         (50)         (50)                                                
   Stomach, Forestomach                               (50)         (50)         (50)                                                
      Squamous Cell Papilloma                                                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (50)         (49)                                                
      Adenoma                                                       1 (2%)                                                          
      Carcinoma                                        1 (2%)       1 (2%)       1 (2%)                                             
   Adrenal Gland, Medulla                             (50)         (50)         (50)                                                
      Pheochromocytoma Benign                          5 (10%)      9 (18%)      4 (8%)                                             
      Bilateral, Pheochromocytoma Benign                            1 (2%)                                                          
   Islets, Pancreatic                                 (49)         (50)         (50)                                                
      Adenoma                                          2 (4%)       1 (2%)                                                          
      Adenoma, Multiple                                1 (2%)                                                                       
      Carcinoma                                                                  1 (2%)                                             
                                                             Page   6                                                               
NTP Experiment-Test: 05038-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            DIMETHOXANE                                        Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 07:33:29  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 MG/KG      62.5 MG/     125 MG/                                                
                                                                KG           KG                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - cont                                                                                                             
   Parathyroid Gland                                  (49)         (46)         (47)                                                
      Adenoma                                          2 (4%)                                                                       
   Pituitary Gland                                    (49)         (50)         (49)                                                
      Pars Distalis, Adenoma                          13 (27%)      7 (14%)     11 (22%)                                            
   Thyroid Gland                                      (50)         (50)         (50)                                                
      Bilateral, C-Cell, Adenoma                       1 (2%)       2 (4%)       2 (4%)                                             
      C-Cell, Adenoma                                 12 (24%)     10 (20%)      8 (16%)                                            
      C-Cell, Carcinoma                                2 (4%)       2 (4%)                                                          
      Follicular Cell, Adenoma                                      3 (6%)                                                          
      Follicular Cell, Carcinoma                                    1 (2%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (48)         (50)         (50)                                                
   Preputial Gland                                    (48)         (47)         (49)                                                
      Adenoma                                                       2 (4%)       2 (4%)                                             
   Prostate                                           (50)         (50)         (50)                                                
   Seminal Vesicle                                    (48)         (49)         (48)                                                
   Testes                                             (50)         (50)         (50)                                                
      Bilateral, Interstitial Cell, Adenoma           32 (64%)     34 (68%)     33 (66%)                                            
      Interstitial Cell, Adenoma                      13 (26%)      9 (18%)     11 (22%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)                                                
   Lymph Node                                         (50)         (50)         (50)                                                
      Carcinoma, Metastatic, Thyroid Gland                          1 (2%)                                                          
   Lymph Node, Mandibular                             (50)         (50)         (49)                                                
      Squamous Cell Carcinoma, Metastatic, Skin                     1 (2%)                                                          
   Spleen                                             (50)         (50)         (50)                                                
      Leiomyosarcoma                                   1 (2%)                                                                       
   Thymus                                             (38)         (40)         (38)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (42)         (43)         (42)                                                
      Fibroadenoma                                     1 (2%)       1 (2%)       2 (5%)                                             
   Skin                                               (50)         (50)         (50)                                                
      Keratoacanthoma                                  1 (2%)       3 (6%)       2 (4%)                                             
                                                             Page   7                                                               
NTP Experiment-Test: 05038-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            DIMETHOXANE                                        Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 07:33:29  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 MG/KG      62.5 MG/     125 MG/                                                
                                                                KG           KG                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - cont                                                                                                         
      Lipoma                                                        1 (2%)                                                          
      Squamous Cell Carcinoma                                       1 (2%)                                                          
      Squamous Cell Papilloma                          1 (2%)       1 (2%)                                                          
      Sebaceous Gland, Adenoma                                                   1 (2%)                                             
      Subcutaneous Tissue, Fibroma                     2 (4%)       1 (2%)       1 (2%)                                             
      Subcutaneous Tissue, Fibrosarcoma                             2 (4%)       2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)                                                
      Astrocytoma Malignant                                         1 (2%)                                                          
      Granular Cell Tumor Malignant                    1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)                                                
      Alveolar/Bronchiolar Adenoma                     2 (4%)                                                                       
      Alveolar/Bronchiolar Carcinoma                                             1 (2%)                                             
      Carcinoma, Metastatic, Uncertain Primary Site                 1 (2%)                                                          
   Nose                                               (50)         (48)         (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Zymbal's Gland                                                  (1)                                                              
      Carcinoma                                                     1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)                                                
      Carcinoma                                                                  1 (2%)                                             
   Urinary Bladder                                    (49)         (49)         (49)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)                                                
      Leukemia Mononuclear                            19 (38%)     14 (28%)      9 (18%)                                            
      Mesothelioma Malignant                           2 (4%)       1 (2%)       1 (2%)                                             
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   8                                                               
NTP Experiment-Test: 05038-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            DIMETHOXANE                                        Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 07:33:29  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 MG/KG      62.5 MG/     125 MG/                                                
                                                                KG           KG                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SYSTEMIC LESIONS - cont                                                                                                            
   Multiple Organs                                   *(50)        *(50)        *(50)                                                
____________________________________________________________________________________________________________________________________
                                                             Page   9                                                               
NTP Experiment-Test: 05038-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            DIMETHOXANE                                        Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 07:33:29  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 MG/KG      62.5 MG/     125 MG/                                                
                                                                KG           KG                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            50          47          48                                                   
     Total Primary Neoplasms                          115         111          95                                                   
                                                                                                                                    
   Total Animals with Benign Neoplasms                 50          45          48                                                   
     Total Benign Neoplasms                            89          87          78                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms              24          23          16                                                   
     Total Malignant Neoplasms                         26          24          17                                                   
                                                                                                                                    
   Total Animals with Metastatic Neoplasms                          4                                                               
     Total Metastatic Neoplasm                                      4                                                               
                                                                                                                                    
   Total Animals with Malignant Neoplasms                           2                                                               
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  10                                                               
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