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TR 354 Rat Pathology Tables

NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11 
LAB: Battelle Columbus                                         DATE: 09/05/94   
EXP: 05038                       DIMETHOXANE                   TIME: 07:44:56   
TEST: 01              CAGES FROM 0000 TO LAST CAGE             PAGE:   1        
TEST TYPE: CHRONIC          ROUTE: GAVAGE                      NTP C#: 56213    
CONT: N01CP9565302                                             CAS: 828-00-2    
PATHOLOGIST: J. TOFT                         S. EUSTIS                          
--------------------------------------------------------------------------------
                                                                                
                                                                                
                                                                                


REASONS FOR REMOVAL:                                                            
                                                                                
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NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11
LAB: Battelle Columbus                                         DATE: 09/05/94  
EXP: 05038                       DIMETHOXANE                   TIME: 07:44:56  
TEST: 01              CAGES FROM 0000 TO LAST CAGE                             
TEST TYPE: CHRONIC          ROUTE: GAVAGE                      NTP C#: 56213   
CONT: N01CP9565302                                             CAS: 828-00-2   
PATHOLOGIST: J. TOFT                         S. EUSTIS                         

                                    DIMETHOXANE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE RATS
                       FIRST TERMINAL SACRIFICE AT 730 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 0 MG/KG                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 25     CENSORED DEATHS 12   TERMINAL 23        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      349   450   500   507   571   588   593   599   617   641                 |
 |      642   652   656   661   666   670   673   683   706   706                 |
 |      717   718   726   726   726                                               |
 |  CENSORED DEATHS                                                               |
 |      465   465   465   465   465   465   465   465   465   465                 |
 |      537   557                                                                 |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 62.5 MG/KG                               |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 19     CENSORED DEATHS 13   TERMINAL 28        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      380   383   416   514   515   563   593   617   619   641                 |
 |      674   677   689   694   695   706   722   722   724                       |
 |  CENSORED DEATHS                                                               |
 |      271   403   465   465   465   465   465   465   465   465                 |
 |      465   465   534                                                           |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 125 MG/ KG                               |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 18     CENSORED DEATHS 21   TERMINAL 21        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      371   423   493   515   555   556   561   561   587   598                 |
 |      611   619   634   645   682   694   694   695                             |
 |  CENSORED DEATHS                                                               |
 |      278   465   465   465   465   465   465   465   465   465                 |
 |      465   538   549   555   555   557   613   627   635   641                 |
 |      665                                                                       |
 |                                                                                |
 ==================================================================================

                                    DIMETHOXANE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE RATS
                       FIRST TERMINAL SACRIFICE AT 730 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   730 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |0 MG/KG    |   100.0 100.0 100.0  98.3  98.3  96.7  92.6  84.2  71.6  48.4      |
 |           |                                                                    |
 |           |                                                                    |
 |62.5 MG/KG |   100.0 100.0 100.0 100.0  94.9  94.9  90.7  86.4  79.9  60.4      |
 |           |                                                                    |
 |           |                                                                    |
 |125 MG/ KG |   100.0 100.0 100.0 100.0  96.6  96.6  92.5  78.8  69.0  57.9      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                    DOSE                        |
 |                                                                                |
 |                                0 MG/KG          62.5 MG/KG       125 MG/ KG    |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       48.4%            60.4%            57.9%         |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=0.655N         P=0.375N         P=0.784N      |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       629.7            607.6            583.0         |
 |NATURAL DEATHS (C)      |       (19.0)           (26.5)           (21.5)        |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       638.0            630.7            611.5         |
 |(STANDARD ERROR)        |       (14.3)           (16.7)           (15.0)        |
 |                        |                                                       |
 ==================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                                    DIMETHOXANE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE RATS
                       FIRST TERMINAL SACRIFICE AT 730 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 0 MG/KG                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 18     CENSORED DEATHS 12   TERMINAL 30        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      85    449   485   515   562   571   580   582   593   625                 |
 |      625   634   642   646   681   683   698   723                             |
 |  CENSORED DEATHS                                                               |
 |      267   465   465   465   465   465   465   465   465   465                 |
 |      465   498                                                                 |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 125 MG/ KG                               |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 16     CENSORED DEATHS 13   TERMINAL 31        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      128   515   526   533   541   544   599   607   670   677                 |
 |      706   709   714   726   726   726                                         |
 |  CENSORED DEATHS                                                               |
 |      459   465   465   465   465   465   465   465   465   465                 |
 |      465   538   615                                                           |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 250 MG/ KG                               |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 15     CENSORED DEATHS 21   TERMINAL 24        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      388   523   538   547   567   597   604   607   625   656                 |
 |      668   668   668   687   715                                               |
 |  CENSORED DEATHS                                                               |
 |      15    205   256   257   297   465   465   465   465   465                 |
 |      465   465   465   465   465   515   538   538   544   554                 |
 |      557                                                                       |
 |                                                                                |
 ==================================================================================

                                    DIMETHOXANE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE RATS
                       FIRST TERMINAL SACRIFICE AT 730 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   730 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |0 MG/KG    |    98.3  98.3  98.3  98.3  98.3  94.6  92.5  82.0  71.5  63.1      |
 |           |                                                                    |
 |           |                                                                    |
 |125 MG/ KG |   100.0  98.3  98.3  98.3  98.3  98.3  88.0  85.9  83.8  66.6      |
 |           |                                                                    |
 |           |                                                                    |
 |250 MG/ KG |   100.0 100.0 100.0 100.0  98.2  98.2  93.6  83.3  75.5  62.5      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                    DOSE                        |
 |                                                                                |
 |                                0 MG/KG          125 MG/ KG       250 MG/ KG    |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       63.1%            66.6%            62.5%         |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=1.000N         P=0.721N         P=1.000N      |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       576.6            602.9            603.9         |
 |NATURAL DEATHS (C)      |       (33.6)           (37.7)           (21.5)        |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       628.2            642.3            591.7         |
 |(STANDARD ERROR)        |       (17.8)           (16.5)           (20.8)        |
 |                        |                                                       |
 ==================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                                                            DIMETHOXANE
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        0 MG/KG          = 1
                                                        62.5 MG/KG       = 2
                                                        125 MG/ KG       = 3

------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  100 + 1                                                      1  3  2
      |                                                        1  3  2    23    1     31
      |                                                                   2           3112
      |                                                                                 13      3 1
P  90 +                                                                                  2       21 1
E     |                                                                                         32  1 11  2
R     |                                                                                                1  1
C     |                                                                                          3  3     1  1
E  80 +                                                                                             3  3 3   2     2
N     |                                                                                                  33  1 1
T     |                                                                                                   3 3      2 2
      |                                                                                                     3 31 11  22
S  70 +                                                                                                       3     3 22
U     |                                                                                                           11   2  2
R     |                                                                                                            11 3
V     |                                                                                                             1  1
I  60 +                                                                                                                1 12 2
V     |                                                                                                               3     3
A     |                                                                                                                  11
L     |
   50 +
      |                                                                                                                   1 1
      |
      |
   40 +
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 14 obs hidden.

                                                            DIMETHOXANE
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        0 MG/KG          = 1
                                                        125 MG/ KG       = 2
                                                        250 MG/ KG       = 3

----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  100 + 1             1      2                                        3
      |               1      2                                        3         1        2 3
      |
      |                                                                         1    1   2 323
   95 +                                                                              1   1
      |                                                                                     22 3
      |                                                                                  1   22  1
      |                                                                                        3 3
P  90 +                                                                                          11
E     |                                                                                          311   3
R     |                                                                                       2        2
C     |                                                                                            11  22
E  85 +
N     |                                                                                             1 1 2         2
T     |                                                                                               1    1
      |                                                                                                 3  3      22
S  80 +                                                                                                            2   2
U     |                                                                                                    3   3
R     |                                                                                                    11          22
V     |                                                                                                     11
I  75 +                                                                                                        3  3
V     |                                                                                                      11
A     |                                                                                                                 2 2
L     |                                                                                                       1     1
   70 +
      |
      |                                                                                                           3 131
      |                                                                                                                   2 2
   65 +                                                                                                              31  31
      |
      |                                                                                                                  31 1
      |
   60 +
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 6 obs hidden.

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