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TR 358 Rat Pathology Tables


                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                            OCHRATOXIN A


NTP Experiment-Test: 05036-01                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 09/05/94
Route: GAVAGE                                                                                                     Time: 02:27:31




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  303-47-9

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05036-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            OCHRATOXIN A                                       Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 02:27:31  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 UG/KG      21 UG/KG     70 UG/KG     210 UG/                                   
                                                                                          KG                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          80           80           80           80                                     
  Scheduled Sacrifice                                 30           29           30           30                                     
  Early Deaths                                                                                                                      
    Moribund                                          10           22           11           11                                     
    Dead                                               7            3            4            4                                     
    Gavage Death                                       1            3                                                               
  Survivors                                                                                                                         
    Terminal Sacrifice                                32           23           35           34                                     
    Dead                                                                                      1                                     
  Animals Examined Microscopically                    50           51           50           50                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (50)         (29)         (19)         (50)                                   
      Carcinoma, Metastatic, Kidney                                              1 (5%)                                             
   Mesentery                                          (1)          (1)          (1)          (1)                                    
      Carcinoma, Metastatic, Kidney                                              1 (100%)                                           
   Pancreas                                           (50)         (29)         (14)         (50)                                   
      Carcinoma, Metastatic, Kidney                                              1 (7%)                                             
      Acinus, Adenoma                                                                         1 (2%)                                
   Pharynx                                            (1)                                                                           
      Squamous Cell Carcinoma                          1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (28)         (15)         (50)                                   
      Sarcoma                                                       1 (4%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (29)         (15)         (50)                                   
      Adenoma                                          2 (4%)                                                                       
      Carcinoma                                                                               1 (2%)                                
      Medulla, Carcinoma, Metastatic, Kidney                                     1 (7%)                                             
   Adrenal Gland, Medulla                             (50)         (27)         (15)         (50)                                   
      Pheochromocytoma Complex                                      1 (4%)                                                          
      Pheochromocytoma Benign                          3 (6%)       1 (4%)       2 (13%)      4 (8%)                                
   Islets, Pancreatic                                 (50)         (28)         (14)         (50)                                   
      Adenoma                                                                    1 (7%)                                             
      Carcinoma, Multiple                              1 (2%)                                                                       
                                                             Page   2                                                               
NTP Experiment-Test: 05036-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            OCHRATOXIN A                                       Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 02:27:31  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 UG/KG      21 UG/KG     70 UG/KG     210 UG/                                   
                                                                                          KG                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - cont                                                                                                             
   Parathyroid Gland                                  (39)         (17)         (13)         (42)                                   
      Adenoma                                                                                 1 (2%)                                
   Pituitary Gland                                    (49)         (41)         (35)         (49)                                   
      Pars Distalis, Adenoma                          16 (33%)     19 (46%)     15 (43%)     22 (45%)                               
      Pars Distalis, Carcinoma                         1 (2%)       2 (5%)       1 (3%)                                             
      Pars Intermedia, Adenoma                                                   1 (3%)                                             
      Pars Intermedia, Carcinoma                                                 1 (3%)                                             
   Thyroid Gland                                      (50)         (32)         (18)         (50)                                   
      Bilateral, C-Cell, Adenoma                                                 1 (6%)       1 (2%)                                
      C-Cell, Adenoma                                  7 (14%)      7 (22%)      4 (22%)      2 (4%)                                
      C-Cell, Carcinoma                                1 (2%)                                                                       
      Follicular Cell, Adenoma                                      1 (3%)                                                          
      Follicular Cell, Carcinoma                                    1 (3%)       1 (6%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (49)         (29)         (17)         (47)                                   
      Adenoma                                          7 (14%)      4 (14%)      2 (12%)      3 (6%)                                
      Carcinoma                                                                  1 (6%)       1 (2%)                                
      Bilateral, Adenoma                                                         1 (6%)                                             
   Ovary                                              (49)         (29)         (19)         (50)                                   
      Carcinoma, Metastatic, Kidney                                              1 (5%)                                             
   Uterus                                             (49)         (32)         (19)         (50)                                   
      Leiomyosarcoma                                                             1 (5%)                                             
      Polyp Stromal                                    2 (4%)       7 (22%)      2 (11%)      6 (12%)                               
      Polyp Stromal, Multiple                                                                 1 (2%)                                
      Sarcoma Stromal                                                            1 (5%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Blood                                              (2)          (2)                                                              
   Bone Marrow                                        (49)         (28)         (15)         (50)                                   
   Lymph Node                                         (50)         (27)         (16)         (50)                                   
      Mediastinal, Basosquamous Tumor Malignant,                                                                                    
           Metastatic, Thymus                                                                 1 (2%)                                
   Lymph Node, Mandibular                             (50)         (26)         (15)         (50)                                   
   Spleen                                             (50)         (29)         (16)         (50)                                   
   Thymus                                             (43)         (27)         (11)         (44)                                   
      Basosquamous Tumor Malignant                                                            1 (2%)                                
      Thymoma Benign                                                                          1 (2%)                                
                                                             Page   3                                                               
NTP Experiment-Test: 05036-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            OCHRATOXIN A                                       Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 02:27:31  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 UG/KG      21 UG/KG     70 UG/KG     210 UG/                                   
                                                                                          KG                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (47)         (40)         (34)         (49)                                   
      Adenocarcinoma                                   1 (2%)       2 (5%)       2 (6%)       2 (4%)                                
      Adenoma                                                                    1 (3%)                                             
      Fibroadenoma                                    13 (28%)     19 (48%)     17 (50%)     14 (29%)                               
      Fibroadenoma, Multiple                           4 (9%)       4 (10%)      5 (15%)     14 (29%)                               
   Skin                                               (49)         (31)         (16)         (50)                                   
      Basosquamous Tumor Benign                                     1 (3%)                                                          
      Squamous Cell Papilloma                                       2 (6%)                    1 (2%)                                
      Subcutaneous Tissue, Fibroma                                  1 (3%)       1 (6%)                                             
      Subcutaneous Tissue, Fibrosarcoma                1 (2%)       2 (6%)                    2 (4%)                                
      Subcutaneous Tissue, Lipoma                                   1 (3%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (28)         (15)         (50)                                   
      Astrocytoma Malignant                                         2 (7%)                                                          
      Carcinoma, Metastatic, Pituitary Gland           1 (2%)                                                                       
      Oligodendroglioma Malignant                                                1 (7%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (32)         (18)         (50)                                   
      Alveolar/Bronchiolar Adenoma                                  1 (3%)                    1 (2%)                                
      Basosquamous Tumor Malignant, Metastatic,                                                                                     
           Thymus                                                                             1 (2%)                                
      Carcinoma, Metastatic, Kidney                                              1 (6%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Zymbal's Gland                                                  (1)          (2)                                                 
      Carcinoma                                                     1 (100%)     2 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   4                                                               
NTP Experiment-Test: 05036-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            OCHRATOXIN A                                       Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 02:27:31  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 UG/KG      21 UG/KG     70 UG/KG     210 UG/                                   
                                                                                          KG                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (51)         (50)         (50)                                   
      Renal Tubule, Adenoma                                                      1 (2%)       3 (6%)                                
      Renal Tubule, Adenoma, Multiple                                                         2 (4%)                                
      Renal Tubule, Carcinoma                                                    1 (2%)       3 (6%)                                
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(51)        *(50)        *(50)                                   
      Leukemia Mononuclear                            10 (20%)      8 (16%)      2 (4%)       3 (6%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   5                                                               
NTP Experiment-Test: 05036-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            OCHRATOXIN A                                       Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 02:27:31  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 UG/KG      21 UG/KG     70 UG/KG     210 UG/                                   
                                                                                          KG                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            39          44          40          45                                       
     Total Primary Neoplasms                           70          88          68          90                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 34          38          34          42                                       
     Total Benign Neoplasms                            54          68          54          77                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              14          19          13          10                                       
     Total Malignant Neoplasms                         16          20          14          13                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              1                       1           1                                       
     Total Metastatic Neoplasm                          1                       6           2                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   6                                                               
NTP Experiment-Test: 05036-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            OCHRATOXIN A                                       Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 02:27:31  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 UG/KG      21 UG/KG     70 UG/KG     210 UG/                                   
                                                                                          KG                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          80           80           80           80                                     
  Scheduled Sacrifice                                 30           29           29           30                                     
  Early Deaths                                                                                                                      
    Gavage Death                                       4            6            2            1                                     
    Moribund                                           7           13           14           23                                     
    Dead                                                            6            9            3                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                39           26           26           23                                     
  Animals Examined Microscopically                    50           51           51           50                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Small, Ileum                             (50)         (24)         (21)         (50)                                   
      Adenocarcinoma                                                                          1 (2%)                                
   Liver                                              (50)         (26)         (26)         (50)                                   
      Carcinoma, Metastatic, Kidney                                                           2 (4%)                                
      Hepatocellular Carcinoma                                                                1 (2%)                                
      Hepatocellular Carcinoma, Multiple               1 (2%)                                                                       
      Neoplastic Nodule                                                                       1 (2%)                                
   Mesentery                                          (1)          (7)          (5)          (11)                                   
      Carcinoma, Metastatic, Kidney                                              1 (20%)      8 (73%)                               
      Sarcoma, Metastatic, Uncertain Primary Site                   1 (14%)                                                         
   Pancreas                                           (50)         (26)         (24)         (50)                                   
      Carcinoma, Metastatic, Kidney                                              4 (17%)      3 (6%)                                
      Sarcoma, Metastatic, Uncertain Primary Site                   1 (4%)                                                          
      Acinus, Adenoma                                  3 (6%)       3 (12%)                   3 (6%)                                
      Acinus, Adenoma, Multiple                        1 (2%)                                                                       
   Pharynx                                            (1)                                                                           
      Palate, Squamous Cell Papilloma                  1 (100%)                                                                     
   Salivary Glands                                    (50)         (26)         (25)         (49)                                   
      Acinus, Adenoma                                  1 (2%)                                                                       
   Stomach, Forestomach                               (50)         (25)         (25)         (50)                                   
      Squamous Cell Papilloma                                                                 1 (2%)                                
   Stomach, Glandular                                 (50)         (25)         (25)         (49)                                   
      Adenocarcinoma                                                                          1 (2%)                                
   Tongue                                                          (3)          (2)          (2)                                    
      Squamous Cell Papilloma                                       2 (67%)      2 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   7                                                               
NTP Experiment-Test: 05036-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            OCHRATOXIN A                                       Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 02:27:31  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 UG/KG      21 UG/KG     70 UG/KG     210 UG/                                   
                                                                                          KG                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (26)         (25)         (50)                                   
      Carcinoma, Metastatic, Kidney                                                           2 (4%)                                
      Atrium, Sarcoma, Metastatic, Uncertain                                                                                        
          Primary Site                                                           1 (4%)                                             
      Epicardium, Carcinoma, Metastatic, Kidney                                               1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (25)         (25)         (50)                                   
      Adenoma                                          2 (4%)                                                                       
      Medulla, Carcinoma, Metastatic, Kidney                                                  1 (2%)                                
   Adrenal Gland, Medulla                             (50)         (25)         (26)         (49)                                   
      Pheochromocytoma Malignant                                                 2 (8%)       1 (2%)                                
      Pheochromocytoma Complex                         1 (2%)                    1 (4%)       1 (2%)                                
      Pheochromocytoma Benign                         13 (26%)      4 (16%)      3 (12%)      9 (18%)                               
      Bilateral, Pheochromocytoma Benign               4 (8%)                    2 (8%)       2 (4%)                                
   Islets, Pancreatic                                 (50)         (26)         (26)         (50)                                   
      Adenoma                                          4 (8%)       2 (8%)       3 (12%)      1 (2%)                                
      Adenoma, Multiple                                1 (2%)                                                                       
      Carcinoma                                        1 (2%)                    1 (4%)       1 (2%)                                
   Parathyroid Gland                                  (41)         (21)         (21)         (47)                                   
      Adenoma                                          2 (5%)                                                                       
   Pituitary Gland                                    (50)         (33)         (27)         (49)                                   
      Pars Distalis, Adenoma                          14 (28%)     16 (48%)      7 (26%)     11 (22%)                               
      Pars Distalis, Carcinoma                                      2 (6%)       2 (7%)                                             
      Pars Intermedia, Adenoma                         1 (2%)                                                                       
   Thyroid Gland                                      (50)         (29)         (26)         (50)                                   
      Carcinoma, Metastatic, Kidney                                                           2 (4%)                                
      Bilateral, C-Cell, Adenoma                       1 (2%)                                                                       
      C-Cell, Adenoma                                  8 (16%)      5 (17%)      6 (23%)      5 (10%)                               
      C-Cell, Carcinoma                                             1 (3%)       1 (4%)       1 (2%)                                
      Follicular Cell, Adenoma                         1 (2%)                    1 (4%)       1 (2%)                                
      Follicular Cell, Carcinoma                       2 (4%)       1 (3%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                                      (1)          (1)          (2)                                    
      Sarcoma                                                                    1 (100%)     1 (50%)                               
      Sarcoma, Metastatic, Uncertain Primary Site                   1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   8                                                               
NTP Experiment-Test: 05036-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            OCHRATOXIN A                                       Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 02:27:31  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 UG/KG      21 UG/KG     70 UG/KG     210 UG/                                   
                                                                                          KG                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (49)         (26)         (25)         (50)                                   
      Carcinoma, Metastatic, Kidney                                                           1 (2%)                                
   Preputial Gland                                    (50)         (28)         (25)         (48)                                   
      Adenoma                                          6 (12%)      3 (11%)      1 (4%)       3 (6%)                                
   Testes                                             (50)         (50)         (48)         (50)                                   
      Bilateral, Interstitial Cell, Adenoma           39 (78%)     34 (68%)     32 (67%)     27 (54%)                               
      Interstitial Cell, Adenoma                       5 (10%)      5 (10%)     10 (21%)     13 (26%)                               
      Tunic, Carcinoma, Metastatic, Kidney                                                    1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Blood                                              (1)                                    (9)                                    
   Bone Marrow                                        (50)         (25)         (25)         (50)                                   
   Lymph Node                                         (50)         (28)         (25)         (50)                                   
      Mediastinal, Carcinoma, Metastatic, Kidney                                 2 (8%)       7 (14%)                               
      Mediastinal, Sarcoma, Metastatic, Uncertain                                                                                   
          Primary Site                                              1 (4%)                                                          
      Mediastinal, Squamous Cell Carcinoma,                                                                                         
          Metastatic, Lung                                                       1 (4%)                                             
      Pancreatic, Adenocarcinoma, Metastatic,                                                                                       
          Stomach                                                                             1 (2%)                                
      Renal, Mediastinal, Pancreatic, Carcinoma,                                                                                    
           Metastatic, Kidney                                                    1 (4%)       1 (2%)                                
   Lymph Node, Mandibular                             (49)         (28)         (23)         (50)                                   
      Carcinoma, Metastatic, Kidney                                                           1 (2%)                                
      Carcinoma, Metastatic, Zymbal's Gland                                                   1 (2%)                                
   Spleen                                             (50)         (29)         (27)         (50)                                   
      Carcinoma, Metastatic, Kidney                                              1 (4%)       2 (4%)                                
      Fibrosarcoma                                     1 (2%)                    1 (4%)                                             
   Thymus                                             (41)         (22)         (20)         (38)                                   
      Carcinoma, Metastatic, Kidney                                                           1 (3%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (39)         (22)         (23)         (40)                                   
      Adenoma                                                                    1 (4%)                                             
      Fibroadenoma                                     3 (8%)       2 (9%)       1 (4%)       3 (8%)                                
   Skin                                               (49)         (32)         (30)         (49)                                   
      Basosquamous Tumor Benign                                     1 (3%)       1 (3%)                                             
      Keratoacanthoma                                  1 (2%)       1 (3%)       4 (13%)      2 (4%)                                
      Squamous Cell Papilloma                          2 (4%)       1 (3%)       4 (13%)      1 (2%)                                
      Trichoepithelioma                                1 (2%)                                                                       
      Sebaceous Gland, Adenoma                         1 (2%)       1 (3%)       1 (3%)       1 (2%)                                
      Subcutaneous Tissue, Fibroma                     4 (8%)       4 (13%)      1 (3%)       2 (4%)                                
                                                             Page   9                                                               
NTP Experiment-Test: 05036-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            OCHRATOXIN A                                       Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 02:27:31  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 UG/KG      21 UG/KG     70 UG/KG     210 UG/                                   
                                                                                          KG                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - cont                                                                                                         
      Subcutaneous Tissue, Fibrosarcoma                1 (2%)                    2 (7%)                                             
      Subcutaneous Tissue, Lipoma                                                             1 (2%)                                
      Subcutaneous Tissue, Sarcoma                     1 (2%)                    1 (3%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (26)         (25)         (50)                                   
      Cranium, Osteosarcoma                                                                   1 (2%)                                
   Skeletal Muscle                                                 (1)                                                              
      Diaphragm, Sarcoma, Metastatic, Uncertain                                                                                     
          Primary Site                                              1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (25)         (25)         (50)                                   
      Astrocytoma Malignant                            1 (2%)                    1 (4%)                                             
      Osteosarcoma, Metastatic, Uncertain Primary                                                                                   
          Site                                                                   1 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (30)         (27)         (50)                                   
      Alveolar/Bronchiolar Adenoma                                  3 (10%)                                                         
      Alveolar/Bronchiolar Carcinoma                                1 (3%)                                                          
      Carcinoma, Metastatic, Kidney                                              3 (11%)     13 (26%)                               
      Carcinoma, Metastatic, Uncertain Primary Site                                           1 (2%)                                
      Pheochromocytoma Malignant, Metastatic,                                                                                       
          Adrenal Gland                                                          2 (7%)                                             
      Squamous Cell Carcinoma                                                    1 (4%)                                             
      Mediastinum, Alveolar/Bronchiolar Carcinoma,                                                                                  
           Metastatic, Lung                                         1 (3%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Zymbal's Gland                                                  (2)                       (3)                                    
      Carcinoma                                                     2 (100%)                  3 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page  10                                                               
NTP Experiment-Test: 05036-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            OCHRATOXIN A                                       Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 02:27:31  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 UG/KG      21 UG/KG     70 UG/KG     210 UG/                                   
                                                                                          KG                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (51)         (51)         (50)                                   
      Mixed Tumor Malignant                            1 (2%)                                                                       
      Sarcoma, Metastatic, Uncertain Primary Site                   1 (2%)                                                          
      Bilateral, Renal Tubule, Carcinoma                                         1 (2%)       3 (6%)                                
      Bilateral, Renal Tubule, Carcinoma, Multiple                                            1 (2%)                                
      Capsule, Carcinoma, Metastatic, Kidney                                                  1 (2%)                                
      Lymphatic, Carcinoma, Metastatic, Kidney                                                1 (2%)                                
      Renal Tubule, Adenoma                            1 (2%)       1 (2%)       3 (6%)      10 (20%)                               
      Renal Tubule, Carcinoma                                                   12 (24%)     20 (40%)                               
      Renal Tubule, Carcinoma, Multiple                                          3 (6%)       6 (12%)                               
      Renal Tubule, Epithelium, Adenoma                                          2 (4%)                                             
      Renal Tubule, Epithelium, Adenoma, Multiple                                1 (2%)                                             
   Urinary Bladder                                    (50)         (23)         (24)         (50)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(51)        *(51)        *(50)                                   
      Leukemia Mononuclear                            12 (24%)      7 (14%)      7 (14%)      7 (14%)                               
      Mesothelioma Benign                                           1 (2%)                                                          
      Mesothelioma Malignant                           1 (2%)       4 (8%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  11                                                               
NTP Experiment-Test: 05036-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            OCHRATOXIN A                                       Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 02:27:31  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 UG/KG      21 UG/KG     70 UG/KG     210 UG/                                   
                                                                                          KG                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            47          47          50          50                                       
     Total Primary Neoplasms                          143         107         123         146                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 47          46          48          44                                       
     Total Benign Neoplasms                           120          89          86          97                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              22          17          28          39                                       
     Total Malignant Neoplasms                         23          18          37          49                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms                          2           9          16                                       
     Total Metastatic Neoplasm                                      7          17          51                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                           1           2           1                                       
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  12                                                               
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