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TR 364 Mouse Pathology Tables


                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                            RHODAMINE 6G


NTP Experiment-Test: 05048-02                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 09/07/94
Route: DOSED FEED                                                                                                 Time: 01:38:26




       Facility:  Southern Research Institute

       Chemical CAS #:  989-38-8

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05048-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            RHODAMINE 6G                                       Date: 09/07/94  
Route: DOSED FEED                                                                                                 Time: 01:38:26  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        UNTREATD     0.05%        0.1%                                                   
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Dead                                               8            7            6                                                  
    Moribund                                           3            8            7                                                  
    Natural Death                                                                1                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                39           35           35                                                  
    Terminal Sacrifice                                                           1                                                  
  Animals Examined Microscopically                    50           50           50                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (50)         (50)         (48)                                                
   Intestine Small                                    (49)         (45)         (48)                                                
      Jejunum, Polyp Adenomatous                       1 (2%)                                                                       
   Liver                                              (50)         (50)         (49)                                                
      Hemangiosarcoma                                  1 (2%)                                                                       
      Hemangiosarcoma, Metastatic, Spleen                                        1 (2%)                                             
      Hepatocellular Carcinoma                         3 (6%)       1 (2%)       4 (8%)                                             
      Hepatocellular Adenoma                           5 (10%)      3 (6%)       1 (2%)                                             
   Mesentery                                          (11)         (3)          (8)                                                 
      Sarcoma Stromal, Focal, Metastatic                                         1 (13%)                                            
   Pancreas                                           (49)         (48)         (47)                                                
   Salivary Glands                                    (49)         (48)         (48)                                                
   Stomach                                            (49)         (48)         (47)                                                
      Forestomach, Squamous Cell Papilloma             1 (2%)       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (49)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (49)         (49)         (49)                                                
      Pheochromocytoma Benign                                                    1 (2%)                                             
   Islets, Pancreatic                                 (50)         (48)         (48)                                                
      Adenoma                                                       1 (2%)       2 (4%)                                             
      Carcinoma                                                     1 (2%)                                                          
   Pituitary Gland                                    (49)         (44)         (46)                                                
      Pars Distalis, Adenoma                           4 (8%)       4 (9%)       6 (13%)                                            
      Pars Distalis, Carcinoma                                      1 (2%)                                                          
                                                             Page   2                                                               
NTP Experiment-Test: 05048-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            RHODAMINE 6G                                       Date: 09/07/94  
Route: DOSED FEED                                                                                                 Time: 01:38:26  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        UNTREATD     0.05%        0.1%                                                   
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - cont                                                                                                             
   Thyroid Gland                                      (50)         (50)         (48)                                                
      Bilateral, Follicular Cell, Adenoma                           1 (2%)                                                          
      Follicular Cell, Adenoma                         1 (2%)       1 (2%)                                                          
      Follicular Cell, Adenoma, Multiple                                         1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (48)         (45)         (48)                                                
      Bilateral, Cystadenoma                                        1 (2%)                                                          
   Uterus                                             (50)         (50)         (49)                                                
      Hemangiosarcoma, Metastatic, Spleen                                        1 (2%)                                             
      Leiomyoma                                                     2 (4%)                                                          
      Polyp Stromal, Metastatic, Glioma Malignant      1 (2%)                                                                       
      Sarcoma                                          1 (2%)                    1 (2%)                                             
      Sarcoma Stromal                                  1 (2%)       1 (2%)       1 (2%)                                             
   Vagina                                                          (1)                                                              
      Squamous Cell Carcinoma                                       1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (48)         (48)         (49)                                                
      Hemangioma                                       1 (2%)                                                                       
      Hemangiosarcoma, Metastatic, Spleen                                        1 (2%)                                             
   Lymph Node                                         (50)         (50)         (49)                                                
      Carcinoma, Metastatic, Harderian Gland                        1 (2%)                                                          
      Fibrosarcoma, Metastatic, Skin                                1 (2%)                                                          
      Sarcoma, Metastatic, Skeletal Muscle                                       1 (2%)                                             
   Spleen                                             (49)         (49)         (49)                                                
      Hemangiosarcoma                                  1 (2%)                    1 (2%)                                             
   Thymus                                             (48)         (48)         (40)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (46)         (47)         (49)                                                
      Adenocarcinoma                                                2 (4%)       2 (4%)                                             
   Skin                                               (50)         (50)         (49)                                                
      Subcutaneous Tissue, Fibrosarcoma                             1 (2%)       1 (2%)                                             
      Tail, Squamous Cell Papilloma                                              1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                             Page   3                                                               
NTP Experiment-Test: 05048-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            RHODAMINE 6G                                       Date: 09/07/94  
Route: DOSED FEED                                                                                                 Time: 01:38:26  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        UNTREATD     0.05%        0.1%                                                   
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                    (1)          (1)          (1)                                                 
      Fibrosarcoma                                     1 (100%)                                                                     
      Sarcoma                                                                    1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (48)         (49)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (49)                                                
      Alveolar/Bronchiolar Adenoma                     3 (6%)       5 (10%)      3 (6%)                                             
      Alveolar/Bronchiolar Carcinoma                   1 (2%)       1 (2%)                                                          
      Carcinoma, Metastatic, Harderian Gland                        1 (2%)                                                          
      Hepatocellular Carcinoma, Metastatic, Liver      1 (2%)                                                                       
      Sarcoma                                                       1 (2%)                                                          
      Sarcoma, Metastatic, Skeletal Muscle                                       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (1)          (5)                                                              
      Adenoma                                                       4 (80%)                                                         
      Carcinoma, Metastatic, Uncertain Primary Site                 1 (20%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (49)                                                
   Urinary Bladder                                    (48)         (47)         (49)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)                                                
      Lymphoma Malignant Histiocytic                   1 (2%)       2 (4%)                                                          
      Lymphoma Malignant Lymphocytic                   6 (12%)      2 (4%)       4 (8%)                                             
      Lymphoma Malignant Mixed                         9 (18%)      4 (8%)       3 (6%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   4                                                               
NTP Experiment-Test: 05048-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            RHODAMINE 6G                                       Date: 09/07/94  
Route: DOSED FEED                                                                                                 Time: 01:38:26  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        UNTREATD     0.05%        0.1%                                                   
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            29          33          25                                                   
     Total Primary Neoplasms                           41          41          33                                                   
                                                                                                                                    
   Total Animals with Benign Neoplasms                 12          20          11                                                   
     Total Benign Neoplasms                            16          23          15                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms              21          17          18                                                   
     Total Malignant Neoplasms                         25          18          18                                                   
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              2           2           3                                                   
     Total Metastatic Neoplasm                          2           4           6                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms                           1                                                               
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   5                                                               
NTP Experiment-Test: 05048-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            RHODAMINE 6G                                       Date: 09/07/94  
Route: DOSED FEED                                                                                                 Time: 01:38:26  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          UNTREATD     0.1%         0.2%                                                   
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Dead                                               5            9            8                                                  
    Moribund                                           8            8            4                                                  
    Moribund Sacrifice                                 1                                                                            
    Accident                                                        1                                                               
  Survivors                                                                                                                         
    Terminal Sacrifice                                36           32           38                                                  
  Animals Examined Microscopically                    50           50           50                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (31)         (30)         (38)                                                
   Intestine Small                                    (46)         (46)         (45)                                                
   Liver                                              (49)         (49)         (50)                                                
      Hepatocellular Carcinoma                         9 (18%)      6 (12%)      5 (10%)                                            
      Hepatocellular Carcinoma, Multiple               1 (2%)                    1 (2%)                                             
      Hepatocellular Adenoma                           5 (10%)      7 (14%)      5 (10%)                                            
   Mesentery                                          (2)          (5)          (5)                                                 
   Pancreas                                           (48)         (49)         (48)                                                
   Stomach                                            (48)         (49)         (50)                                                
      Forestomach, Squamous Cell Papilloma             2 (4%)       1 (2%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (49)         (48)         (49)                                                
      Pheochromocytoma Benign                                                    1 (2%)                                             
      Cortex, Adenoma                                               1 (2%)                                                          
   Thyroid Gland                                      (50)         (49)         (50)                                                
      C-Cell, Carcinoma                                1 (2%)                                                                       
      Follicular Cell, Adenoma                                      3 (6%)       3 (6%)                                             
      Follicular Cell, Carcinoma                                    1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                             Page   6                                                               
NTP Experiment-Test: 05048-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            RHODAMINE 6G                                       Date: 09/07/94  
Route: DOSED FEED                                                                                                 Time: 01:38:26  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          UNTREATD     0.1%         0.2%                                                   
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Preputial Gland                                    (12)         (15)         (25)                                                
      Adenoma                                                                    1 (4%)                                             
   Prostate                                           (47)         (48)         (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (49)         (49)         (50)                                                
   Lymph Node                                         (50)         (50)         (50)                                                
      Fibrosarcoma, Metastatic, Skin                   2 (4%)       1 (2%)                                                          
      Sarcoma, Metastatic, Skin                        1 (2%)                                                                       
   Spleen                                             (49)         (49)         (48)                                                
      Hemangiosarcoma                                  1 (2%)                                                                       
   Thymus                                             (31)         (40)         (47)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (48)         (50)         (50)                                                
      Squamous Cell Papilloma                          1 (2%)                                                                       
      Subcutaneous Tissue, Fibroma                                  4 (8%)       2 (4%)                                             
      Subcutaneous Tissue, Fibrosarcoma                9 (19%)     12 (24%)      5 (10%)                                            
      Subcutaneous Tissue, Fibrosarcoma, Multiple      1 (2%)                    1 (2%)                                             
      Subcutaneous Tissue, Hemangioma                  1 (2%)                                                                       
      Subcutaneous Tissue, Sarcoma                     4 (8%)       2 (4%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                    (1)                       (2)                                                 
      Fibrosarcoma                                     1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   7                                                               
NTP Experiment-Test: 05048-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            RHODAMINE 6G                                       Date: 09/07/94  
Route: DOSED FEED                                                                                                 Time: 01:38:26  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          UNTREATD     0.1%         0.2%                                                   
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)                                                
      Alveolar/Bronchiolar Adenoma                     5 (10%)      5 (10%)      4 (8%)                                             
      Alveolar/Bronchiolar Adenoma, Multiple           1 (2%)                                                                       
      Alveolar/Bronchiolar Carcinoma                   3 (6%)       2 (4%)       1 (2%)                                             
      Carcinoma, Metastatic, Thyroid Gland             1 (2%)                                                                       
      Fibrosarcoma, Metastatic, Skin                   2 (4%)       2 (4%)       1 (2%)                                             
      Hepatocellular Carcinoma, Metastatic, Liver      2 (4%)       2 (4%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (8)          (2)          (3)                                                 
      Adenoma                                          7 (88%)      2 (100%)     2 (67%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (49)         (50)                                                
      Fibrosarcoma, Metastatic, Skin                   1 (2%)                                                                       
      Cortex, Renal Tubule, Adenoma                    1 (2%)                                                                       
   Urethra                                                         (1)          (1)                                                 
      Bulbourethral Gland, Leiomyosarcoma                                        1 (100%)                                           
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)                                                
      Lymphoma Malignant                               1 (2%)                                                                       
      Lymphoma Malignant Histiocytic                                3 (6%)       1 (2%)                                             
      Lymphoma Malignant Lymphocytic                   3 (6%)                    1 (2%)                                             
      Lymphoma Malignant Mixed                         1 (2%)       1 (2%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   8                                                               
NTP Experiment-Test: 05048-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            RHODAMINE 6G                                       Date: 09/07/94  
Route: DOSED FEED                                                                                                 Time: 01:38:26  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          UNTREATD     0.1%         0.2%                                                   
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            39          33          29                                                   
     Total Primary Neoplasms                           58          51          37                                                   
                                                                                                                                    
   Total Animals with Benign Neoplasms                 18          17          15                                                   
     Total Benign Neoplasms                            23          23          19                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms              30          25          16                                                   
     Total Malignant Neoplasms                         35          28          18                                                   
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              8           4           1                                                   
     Total Metastatic Neoplasm                          9           5           1                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   9                                                               
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