National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/1325

TR 364 Rat Pathology Tables


                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                                            RHODAMINE 6G


NTP Experiment-Test: 05048-01                                                                                     Report: PEIRPT03
Study Type: CHRONIC                                                                                               Date: 09/06/94
Route: DOSED FEED                                                                                                 Time: 23:49:35




       Facility:  Southern Research Institute

       Chemical CAS #:  989-38-8

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05048-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            RHODAMINE 6G                                       Date: 09/06/94  
Route: DOSED FEED                                                                                                 Time: 23:49:35  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   UNTREATD     0.012%       0.025%                                                 
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Moribund                                          17           16           18                                                  
    Dead                                               4            4            2                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                29           30           30                                                  
  Animals Examined Microscopically                    50           50           50                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large                                    (50)         (49)         (50)                                                
      Cecum, Parasite Metazoan                         2 (4%)                                                                       
      Colon, Parasite Metazoan                         2 (4%)       2 (4%)                                                          
      Rectum, Parasite Metazoan                        1 (2%)       1 (2%)                                                          
   Liver                                              (50)         (49)         (50)                                                
      Angiectasis, Focal                               1 (2%)       1 (2%)       1 (2%)                                             
      Basophilic Focus                                11 (22%)      8 (16%)      5 (10%)                                            
      Basophilic Focus, Multiple                      18 (36%)     22 (45%)     28 (56%)                                            
      Clear Cell Focus                                 2 (4%)                                                                       
      Congestion, Diffuse                                                        1 (2%)                                             
      Developmental Malformation                       4 (8%)       4 (8%)       3 (6%)                                             
      Granuloma                                        1 (2%)       1 (2%)       1 (2%)                                             
      Granuloma, Multifocal                           17 (34%)     18 (37%)     16 (32%)                                            
      Hematopoietic Cell Proliferation, Multifocal     1 (2%)                    2 (4%)                                             
      Hemorrhage, Multifocal                                                     1 (2%)                                             
      Hepatodiaphragmatic Nodule                                    2 (4%)       3 (6%)                                             
      Mixed Cell Focus                                                           1 (2%)                                             
      Necrosis, Focal                                  1 (2%)       1 (2%)       1 (2%)                                             
      Necrosis, Multifocal                             2 (4%)                    2 (4%)                                             
      Pigmentation, Hemosiderin, Multifocal                                      1 (2%)                                             
      Thrombosis, Multiple                                                       1 (2%)                                             
      Vacuolization Cytoplasmic, Diffuse               6 (12%)      8 (16%)      7 (14%)                                            
      Vacuolization Cytoplasmic, Focal                              2 (4%)       1 (2%)                                             
      Biliary Tract, Hyperplasia                      14 (28%)     19 (39%)     13 (26%)                                            
      Centrilobular, Necrosis                          7 (14%)      6 (12%)      7 (14%)                                            
      Hepatocyte, Hypertrophy                          5 (10%)      6 (12%)      4 (8%)                                             
   Mesentery                                          (2)          (2)          (9)                                                 
      Inflammation, Chronic, Focal                     1 (50%)                                                                      
      Fat, Necrosis, Focal                             1 (50%)      2 (100%)     9 (100%)                                           
   Pancreas                                           (48)         (49)         (50)                                                
      Atrophy                                          7 (15%)      9 (18%)      8 (16%)                                            
      Inflammation, Focal, Subacute                    1 (2%)                                                                       
      Artery, Inflammation, Subacute                                1 (2%)                                                          
   Salivary Glands                                    (50)         (49)         (49)                                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05048-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            RHODAMINE 6G                                       Date: 09/06/94  
Route: DOSED FEED                                                                                                 Time: 23:49:35  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   UNTREATD     0.012%       0.025%                                                 
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Inflammation, Multifocal, Subacute                                         1 (2%)                                             
      Duct, Cyst                                                    1 (2%)       2 (4%)                                             
   Stomach                                            (50)         (50)         (50)                                                
      Artery, Inflammation, Subacute                   1 (2%)                                                                       
      Forestomach, Edema                                            1 (2%)       4 (8%)                                             
      Forestomach, Hyperkeratosis                      3 (6%)       5 (10%)      2 (4%)                                             
      Forestomach, Hyperplasia                         3 (6%)       5 (10%)      3 (6%)                                             
      Forestomach, Inflammation, Subacute              4 (8%)       4 (8%)                                                          
      Forestomach, Perforation                         2 (4%)                                                                       
      Forestomach, Ulcer                               2 (4%)       4 (8%)       4 (8%)                                             
      Forestomach, Ulcer, Multiple                                  1 (2%)       1 (2%)                                             
      Glandular, Edema                                              1 (2%)                                                          
      Glandular, Erosion                                            1 (2%)       1 (2%)                                             
      Glandular, Inflammation, Subacute                2 (4%)       1 (2%)                                                          
      Glandular, Mineralization                        1 (2%)                                                                       
      Glandular, Ulcer                                              1 (2%)       1 (2%)                                             
   Tooth                                                                        (1)                                                 
      Inflammation, Acute, Suppurative                                           1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)                                                
      Fibrosis, Multifocal                            16 (32%)     26 (52%)     22 (44%)                                            
      Atrium, Mineralization, Focal                                              1 (2%)                                             
      Atrium, Pigmentation, Hemosiderin                                          1 (2%)                                             
      Atrium, Thrombosis                                                         1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (50)         (50)         (50)                                                
      Accessory Adrenal Cortical Nodule                             1 (2%)                                                          
      Cortex, Angiectasis, Focal                       1 (2%)       1 (2%)                                                          
      Cortex, Angiectasis, Multifocal                  1 (2%)                    1 (2%)                                             
      Cortex, Congestion, Diffuse                                   1 (2%)       1 (2%)                                             
      Cortex, Degeneration, Fatty, Focal               5 (10%)     13 (26%)      7 (14%)                                            
      Cortex, Degeneration, Fatty, Multifocal          2 (4%)       4 (8%)       5 (10%)                                            
      Cortex, Hyperplasia, Focal                       1 (2%)       2 (4%)       2 (4%)                                             
      Cortex, Hypertrophy, Focal                       1 (2%)                                                                       
      Cortex, Necrosis, Focal                                       1 (2%)                                                          
      Medulla, Hyperplasia, Focal                      4 (8%)       6 (12%)      8 (16%)                                            
   Parathyroid Gland                                  (46)         (48)         (46)                                                
      Hyperplasia                                      1 (2%)                                                                       
   Pituitary Gland                                    (49)         (49)         (50)                                                
      Hemorrhage, Focal                                1 (2%)       1 (2%)                                                          
      Pars Distalis, Angiectasis                      34 (69%)     30 (61%)     30 (60%)                                            
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05048-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            RHODAMINE 6G                                       Date: 09/06/94  
Route: DOSED FEED                                                                                                 Time: 23:49:35  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   UNTREATD     0.012%       0.025%                                                 
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Pars Distalis, Cyst                             11 (22%)     18 (37%)      8 (16%)                                            
      Pars Distalis, Hyperplasia, Focal                7 (14%)      7 (14%)      9 (18%)                                            
      Pars Distalis, Pigmentation, Hemosiderin        25 (51%)     17 (35%)     15 (30%)                                            
   Thyroid Gland                                      (50)         (50)         (50)                                                
      C-Cell, Hyperplasia, Focal                       3 (6%)       1 (2%)       5 (10%)                                            
      C-Cell, Hyperplasia, Multifocal                  1 (2%)       2 (4%)       1 (2%)                                             
      Follicle, Cyst                                   1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (42)         (40)         (39)                                                
      Cyst                                             5 (12%)      2 (5%)       4 (10%)                                            
      Inflammation, Acute, Suppurative                 1 (2%)       4 (10%)      3 (8%)                                             
      Inflammation, Focal, Subacute                    3 (7%)       1 (3%)       1 (3%)                                             
   Ovary                                              (50)         (49)         (50)                                                
      Cyst                                             2 (4%)       5 (10%)      6 (12%)                                            
   Uterus                                             (49)         (50)         (50)                                                
      Hemorrhage, Focal                                1 (2%)                    1 (2%)                                             
      Hydrometra                                                    2 (4%)       1 (2%)                                             
      Inflammation, Acute, Suppurative                 2 (4%)                                                                       
      Necrosis                                         2 (4%)                                                                       
      Cervix, Abscess                                               5 (10%)      5 (10%)                                            
      Cervix, Cyst                                     2 (4%)       5 (10%)      3 (6%)                                             
      Cervix, Necrosis                                              1 (2%)                                                          
      Endometrium, Hyperplasia, Cystic                                           1 (2%)                                             
      Mucosa, Cyst                                     1 (2%)                    1 (2%)                                             
   Vagina                                             (1)                                                                           
      Abscess                                          1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)                                                
      Hyperplasia                                      3 (6%)                    2 (4%)                                             
   Lymph Node                                         (50)         (49)         (50)                                                
      Deep Cervical, Congestion                                     1 (2%)                                                          
      Inguinal, Hyperplasia                                         1 (2%)       1 (2%)                                             
      Mandibular, Ectasia                                           2 (4%)       1 (2%)                                             
      Mandibular, Hyperplasia                          1 (2%)                                                                       
      Mesenteric, Congestion                                                     1 (2%)                                             
   Spleen                                             (49)         (49)         (50)                                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05048-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            RHODAMINE 6G                                       Date: 09/06/94  
Route: DOSED FEED                                                                                                 Time: 23:49:35  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   UNTREATD     0.012%       0.025%                                                 
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Congestion                                                                 1 (2%)                                             
      Fibrosis, Focal                                  1 (2%)                                                                       
      Hematopoietic Cell Proliferation                 7 (14%)      5 (10%)      5 (10%)                                            
      Hyperplasia, Focal, Lymphoid                                  1 (2%)                                                          
      Necrosis, Focal                                               1 (2%)                                                          
   Thymus                                             (43)         (46)         (49)                                                
      Cyst                                                                       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (50)         (50)                                                
      Hemorrhage                                       1 (2%)       1 (2%)                                                          
      Hyperplasia, Glandular                           1 (2%)       3 (6%)       1 (2%)                                             
      Duct, Cyst                                      47 (94%)     44 (88%)     42 (84%)                                            
      Duct, Cyst, Multiple                                                       1 (2%)                                             
   Skin                                               (50)         (50)         (50)                                                
      Cyst Epithelial Inclusion                                                  1 (2%)                                             
      Foreign Body                                                  3 (6%)                                                          
      Hyperkeratosis, Focal                                         1 (2%)                                                          
      Hyperplasia                                      1 (2%)                                                                       
      Hyperplasia, Focal                                            1 (2%)                                                          
      Inflammation, Acute, Focal, Suppurative          1 (2%)       2 (4%)       1 (2%)                                             
      Inflammation, Focal, Subacute                    1 (2%)                                                                       
      Inflammation, Granulomatous, Multifocal                       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)                                                
      Cranium, Hyperostosis, Focal                                  1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)                                                
      Compression                                      4 (8%)       4 (8%)       3 (6%)                                             
      Degeneration, Multifocal                         2 (4%)       7 (14%)                                                         
      Hemorrhage, Multifocal                           1 (2%)       2 (4%)                                                          
      Mineralization, Focal                                         1 (2%)                                                          
      Necrosis, Multifocal                                                       1 (2%)                                             
      Cerebellum, Mineralization, Multifocal                        1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05048-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            RHODAMINE 6G                                       Date: 09/06/94  
Route: DOSED FEED                                                                                                 Time: 23:49:35  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   UNTREATD     0.012%       0.025%                                                 
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)                                                
      Atelectasis, Multifocal                                       1 (2%)                                                          
      Congestion                                                    1 (2%)                                                          
      Foreign Body, Multiple                           1 (2%)                                                                       
      Granuloma, Multifocal                            1 (2%)                                                                       
      Hemorrhage, Multifocal                                        2 (4%)                                                          
      Hyperplasia, Macrophage                                                    1 (2%)                                             
      Metaplasia, Multifocal, Osseous                  1 (2%)                                                                       
      Pigmentation, Hemosiderin                        1 (2%)                    1 (2%)                                             
      Alveolar Epithelium, Hyperplasia, Focal                                    1 (2%)                                             
   Nose                                               (49)         (50)         (47)                                                
      Foreign Body                                     1 (2%)                                                                       
      Fungus                                                        2 (4%)       1 (2%)                                             
      Inflammation, Acute, Suppurative                 2 (4%)       3 (6%)       2 (4%)                                             
      Inflammation, Granulomatous                      1 (2%)                                                                       
      Nasolacrimal Duct, Foreign Body                                            1 (2%)                                             
      Nasolacrimal Duct, Inflammation, Acute,                                                                                       
          Suppurative                                  3 (6%)       1 (2%)       2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                (4)          (11)         (12)                                                
      Inflammation, Acute, Suppurative                                           1 (8%)                                             
   Eye                                                (2)          (21)         (6)                                                 
      Cataract                                         1 (50%)     21 (100%)     3 (50%)                                            
      Hemorrhage                                       1 (50%)                                                                      
      Cornea, Inflammation, Chronic                                              2 (33%)                                            
      Retina, Degeneration                             2 (100%)    21 (100%)     5 (83%)                                            
   Lacrimal Gland                                     (1)          (3)          (1)                                                 
      Ectopic Harderian                                1 (100%)     3 (100%)     1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)                                                
      Nephropathy, Chronic                            39 (78%)     37 (74%)     36 (72%)                                            
      Cortex, Cyst                                     1 (2%)                                                                       
      Cortex, Inflammation, Acute, Multifocal,                                                                                      
           Suppurative                                 1 (2%)                                                                       
      Medulla, Mineralization, Focal                                             1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05048-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            RHODAMINE 6G                                       Date: 09/06/94  
Route: DOSED FEED                                                                                                 Time: 23:49:35  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   UNTREATD     0.012%       0.025%                                                 
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Right, Hydronephrosis                                         1 (2%)                                                          
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 05048-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            RHODAMINE 6G                                       Date: 09/06/94  
Route: DOSED FEED                                                                                                 Time: 23:49:35  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     UNTREATD     0.012%       0.025%                                                 
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Moribund                                          23           25           19                                                  
    Dead                                               5            4            4                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                22           20           27                                                  
    Dead                                                            1                                                               
  Animals Examined Microscopically                    50           50           50                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large                                    (50)         (49)         (50)                                                
      Cecum, Inflammation, Subacute                                              2 (4%)                                             
      Cecum, Parasite Metazoan                                      1 (2%)                                                          
      Colon, Cyst                                      1 (2%)                                                                       
      Colon, Diverticulum                              1 (2%)                                                                       
      Colon, Edema                                     1 (2%)                                                                       
      Colon, Parasite Metazoan                         6 (12%)      5 (10%)      1 (2%)                                             
      Rectum, Mineralization                           1 (2%)       1 (2%)                                                          
      Rectum, Parasite Metazoan                        1 (2%)       4 (8%)                                                          
   Intestine Small                                    (50)         (49)         (50)                                                
      Peyer's Patch, Mineralization, Focal                          1 (2%)                                                          
      Peyer's Patch, Necrosis, Focal                                1 (2%)                                                          
   Liver                                              (50)         (50)         (50)                                                
      Angiectasis, Focal                               7 (14%)      6 (12%)      8 (16%)                                            
      Angiectasis, Multifocal                          8 (16%)      2 (4%)       6 (12%)                                            
      Basophilic Focus                                 2 (4%)       4 (8%)       5 (10%)                                            
      Basophilic Focus, Multiple                       3 (6%)       1 (2%)       2 (4%)                                             
      Clear Cell Focus                                                           1 (2%)                                             
      Congestion                                                    3 (6%)                                                          
      Degeneration, Fatty, Focal                                                 1 (2%)                                             
      Developmental Malformation                       5 (10%)      1 (2%)       5 (10%)                                            
      Eosinophilic Focus                                            2 (4%)                                                          
      Eosinophilic Focus, Multiple                                               1 (2%)                                             
      Fibrosis, Focal                                  1 (2%)                                                                       
      Granuloma, Focal                                                           1 (2%)                                             
      Granuloma, Multifocal                            2 (4%)       2 (4%)       2 (4%)                                             
      Hematopoietic Cell Proliferation                              1 (2%)                                                          
      Hemorrhage, Focal                                1 (2%)                                                                       
      Hemorrhage, Multifocal                                        1 (2%)                                                          
      Hepatodiaphragmatic Nodule                                    1 (2%)                                                          
      Necrosis, Focal                                                            1 (2%)                                             
      Necrosis, Multifocal                             1 (2%)       1 (2%)       1 (2%)                                             
      Pigmentation, Focal, Hemosiderin                 1 (2%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
NTP Experiment-Test: 05048-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            RHODAMINE 6G                                       Date: 09/06/94  
Route: DOSED FEED                                                                                                 Time: 23:49:35  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     UNTREATD     0.012%       0.025%                                                 
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Pigmentation, Hemosiderin, Multifocal                         1 (2%)                                                          
      Thrombosis                                                    1 (2%)                                                          
      Vacuolization Cytoplasmic, Diffuse               3 (6%)       3 (6%)       5 (10%)                                            
      Vacuolization Cytoplasmic, Focal                 1 (2%)       3 (6%)                                                          
      Vacuolization Cytoplasmic, Multifocal            1 (2%)       1 (2%)                                                          
      Biliary Tract, Hyperplasia                      32 (64%)     37 (74%)     39 (78%)                                            
      Centrilobular, Necrosis                         12 (24%)     19 (38%)     13 (26%)                                            
      Hepatocyte, Hypertrophy                          1 (2%)       8 (16%)      4 (8%)                                             
   Mesentery                                          (2)          (4)          (4)                                                 
      Hemorrhage                                                                 2 (50%)                                            
      Inflammation, Diffuse, Subacute                                            1 (25%)                                            
      Fat, Necrosis, Focal                             2 (100%)     2 (50%)      2 (50%)                                            
   Pancreas                                           (50)         (49)         (50)                                                
      Atrophy                                          9 (18%)     18 (37%)     11 (22%)                                            
      Acinus, Hyperplasia                                           1 (2%)                                                          
      Artery, Hypertrophy                                                        1 (2%)                                             
      Artery, Inflammation, Subacute                   3 (6%)       2 (4%)       1 (2%)                                             
   Salivary Glands                                    (50)         (49)         (50)                                                
      Infiltration Cellular, Multifocal, Lymphocyte                              1 (2%)                                             
   Stomach                                            (49)         (50)         (50)                                                
      Inflammation, Subacute                                                     1 (2%)                                             
      Artery, Inflammation, Subacute                   1 (2%)       1 (2%)                                                          
      Forestomach, Edema                                            1 (2%)                                                          
      Forestomach, Foreign Body                        1 (2%)                                                                       
      Forestomach, Hyperkeratosis                      1 (2%)       2 (4%)       4 (8%)                                             
      Forestomach, Hyperplasia                         1 (2%)       2 (4%)       4 (8%)                                             
      Forestomach, Inflammation, Focal,                                                                                             
          Granulomatous                                1 (2%)                                                                       
      Forestomach, Inflammation, Subacute              2 (4%)       2 (4%)       2 (4%)                                             
      Forestomach, Mineralization                      1 (2%)       2 (4%)                                                          
      Forestomach, Ulcer                               3 (6%)       1 (2%)       1 (2%)                                             
      Glandular, Edema                                              1 (2%)                                                          
      Glandular, Erosion                                            1 (2%)       1 (2%)                                             
      Glandular, Erosion, Multiple                                  1 (2%)                                                          
      Glandular, Mineralization                        1 (2%)       5 (10%)      1 (2%)                                             
      Glandular, Ulcer                                 1 (2%)                                                                       
      Glandular, Ulcer, Multiple                       1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (1)          (2)          (1)                                                 
      Mineralization                                   1 (100%)     2 (100%)     1 (100%)                                           
   Heart                                              (50)         (50)         (50)                                                
      Bacterium                                                     1 (2%)                                                          
      Fibrosis, Multifocal                            35 (70%)     40 (80%)     40 (80%)                                            
      Inflammation, Acute, Suppurative                              1 (2%)                                                          
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    9                                                              
NTP Experiment-Test: 05048-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            RHODAMINE 6G                                       Date: 09/06/94  
Route: DOSED FEED                                                                                                 Time: 23:49:35  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     UNTREATD     0.012%       0.025%                                                 
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
CARDIOVASCULAR SYSTEM - CONT                                                                                                        
      Mineralization                                   1 (2%)       2 (4%)       1 (2%)                                             
      Atrium, Thrombosis                               3 (6%)       3 (6%)       2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (50)         (49)         (50)                                                
      Hyperplasia, Focal                                            1 (2%)                                                          
      Cortex, Angiectasis, Focal                       2 (4%)                                                                       
      Cortex, Congestion                               1 (2%)                                                                       
      Cortex, Degeneration, Diffuse, Fatty                                       1 (2%)                                             
      Cortex, Degeneration, Fatty, Focal               1 (2%)       5 (10%)      6 (12%)                                            
      Cortex, Degeneration, Fatty, Multifocal          2 (4%)                    1 (2%)                                             
      Cortex, Hemorrhage, Multifocal                                             1 (2%)                                             
      Cortex, Hyperplasia, Focal                                                 2 (4%)                                             
      Cortex, Hyperplasia, Multifocal                  1 (2%)                                                                       
      Cortex, Hyperplasia, Multifocal, Multifocal      1 (2%)                                                                       
      Cortex, Necrosis, Diffuse                                                  1 (2%)                                             
      Cortex, Necrosis, Multifocal                                               2 (4%)                                             
      Medulla, Hematopoietic Cell Proliferation                     1 (2%)       2 (4%)                                             
      Medulla, Hyperplasia, Focal                      6 (12%)     10 (20%)      2 (4%)                                             
      Medulla, Hyperplasia, Multifocal                 1 (2%)       1 (2%)       1 (2%)                                             
      Medulla, Necrosis, Diffuse                                                 1 (2%)                                             
      Medulla, Necrosis, Multifocal                    1 (2%)                                                                       
   Islets, Pancreatic                                 (50)         (49)         (50)                                                
      Hyperplasia                                      1 (2%)       1 (2%)                                                          
   Parathyroid Gland                                  (47)         (46)         (48)                                                
      Hyperplasia                                      4 (9%)       4 (9%)       3 (6%)                                             
   Pituitary Gland                                    (49)         (49)         (49)                                                
      Pars Distalis, Angiectasis                       6 (12%)      5 (10%)     11 (22%)                                            
      Pars Distalis, Cyst                              2 (4%)       1 (2%)       1 (2%)                                             
      Pars Distalis, Hemorrhage, Focal                 1 (2%)                    1 (2%)                                             
      Pars Distalis, Hyperplasia, Focal                2 (4%)       5 (10%)      2 (4%)                                             
      Pars Distalis, Pigmentation, Hemosiderin         4 (8%)       2 (4%)       7 (14%)                                            
   Thyroid Gland                                      (50)         (48)         (50)                                                
      Ultimobranchial Cyst                             1 (2%)       2 (4%)       1 (2%)                                             
      C-Cell, Hyperplasia, Focal                       1 (2%)       2 (4%)       1 (2%)                                             
      C-Cell, Hyperplasia, Multifocal                  1 (2%)                    1 (2%)                                             
      Follicle, Cyst                                   2 (4%)       1 (2%)       1 (2%)                                             
      Follicle, Hyperplasia, Cystic, Focal             1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   10                                                              
NTP Experiment-Test: 05048-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            RHODAMINE 6G                                       Date: 09/06/94  
Route: DOSED FEED                                                                                                 Time: 23:49:35  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     UNTREATD     0.012%       0.025%                                                 
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Preputial Gland                                    (49)         (48)         (43)                                                
      Hyperplasia                                                                1 (2%)                                             
      Inflammation, Acute, Suppurative                 4 (8%)       8 (17%)      6 (14%)                                            
      Inflammation, Chronic                                         1 (2%)                                                          
      Inflammation, Subacute                           2 (4%)                    1 (2%)                                             
      Duct, Cyst                                       3 (6%)       6 (13%)      3 (7%)                                             
   Prostate                                           (50)         (49)         (50)                                                
      Concretion                                                    1 (2%)                                                          
      Cyst                                                                       1 (2%)                                             
      Edema                                                                      1 (2%)                                             
      Fibrosis                                                      1 (2%)                                                          
      Hemorrhage                                       1 (2%)                                                                       
      Inflammation, Acute, Suppurative                19 (38%)     16 (33%)     19 (38%)                                            
      Inflammation, Chronic                            5 (10%)      1 (2%)       1 (2%)                                             
      Inflammation, Subacute                                        3 (6%)       1 (2%)                                             
   Seminal Vesicle                                                 (4)          (2)                                                 
      Inflammation, Acute, Suppurative                                           1 (50%)                                            
      Inflammation, Chronic                                         1 (25%)                                                         
   Testes                                             (49)         (50)         (50)                                                
      Angiectasis                                                                1 (2%)                                             
      Atrophy                                          2 (4%)       2 (4%)       4 (8%)                                             
      Inflammation, Acute, Suppurative                 1 (2%)                                                                       
      Mineralization                                                1 (2%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)                                                
      Hyperplasia                                                   1 (2%)       2 (4%)                                             
   Lymph Node                                         (50)         (49)         (50)                                                
      Deep Cervical, Congestion                                     1 (2%)                                                          
      Iliac, Ectasia                                   1 (2%)                                                                       
      Inguinal, Hyperplasia                            1 (2%)                                                                       
      Lumbar, Ectasia                                               2 (4%)                                                          
      Mandibular, Congestion                                                     1 (2%)                                             
      Mandibular, Ectasia                              7 (14%)      7 (14%)      6 (12%)                                            
      Mediastinal, Congestion                                                    1 (2%)                                             
      Mediastinal, Hyperplasia                         1 (2%)                                                                       
      Mesenteric, Angiectasis                          2 (4%)                    1 (2%)                                             
      Mesenteric, Congestion                           1 (2%)                                                                       
      Mesenteric, Ectasia                              2 (4%)       5 (10%)      4 (8%)                                             
      Pancreatic, Ectasia                                           1 (2%)       1 (2%)                                             
      Pancreatic, Hyperplasia                                       1 (2%)                                                          
   Spleen                                             (50)         (50)         (50)                                                
      Atrophy                                          2 (4%)                    1 (2%)                                             
      Congestion                                                    1 (2%)       1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   11                                                              
NTP Experiment-Test: 05048-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            RHODAMINE 6G                                       Date: 09/06/94  
Route: DOSED FEED                                                                                                 Time: 23:49:35  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     UNTREATD     0.012%       0.025%                                                 
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Developmental Malformation                       1 (2%)                                                                       
      Fibrosis                                         7 (14%)      7 (14%)      7 (14%)                                            
      Hematopoietic Cell Proliferation                 1 (2%)       4 (8%)       5 (10%)                                            
      Inflammation, Acute, Suppurative                              1 (2%)                                                          
      Necrosis, Focal                                               1 (2%)       1 (2%)                                             
      Pigmentation, Hemosiderin                                                  1 (2%)                                             
      Capsule, Fibrosis, Focal                         1 (2%)                                                                       
   Thymus                                             (47)         (47)         (47)                                                
      Cyst                                                          1 (2%)       1 (2%)                                             
      Mediastinum, Inflammation, Acute, Suppurative                 1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (49)         (46)                                                
      Granuloma                                                                  1 (2%)                                             
      Inflammation, Chronic, Focal                                               1 (2%)                                             
      Pigmentation, Hemosiderin                                                  1 (2%)                                             
      Duct, Cyst                                      10 (20%)     18 (37%)     22 (48%)                                            
   Skin                                               (50)         (50)         (50)                                                
      Abscess                                                                    1 (2%)                                             
      Alopecia                                         1 (2%)                                                                       
      Cyst Epithelial Inclusion                        1 (2%)       2 (4%)                                                          
      Hyperkeratosis, Focal                            1 (2%)       1 (2%)       1 (2%)                                             
      Hyperplasia                                                   1 (2%)                                                          
      Hyperplasia, Focal                               1 (2%)       1 (2%)       2 (4%)                                             
      Inflammation, Acute, Focal, Suppurative          2 (4%)       2 (4%)       1 (2%)                                             
      Inflammation, Chronic, Focal                                  1 (2%)       1 (2%)                                             
      Inflammation, Focal, Granulomatous               1 (2%)                    1 (2%)                                             
      Inflammation, Focal, Subacute                                 1 (2%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)                                                
      Fibrous Osteodystrophy                           3 (6%)       3 (6%)       2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)                                                
      Bacterium                                                                  1 (2%)                                             
      Compression                                      1 (2%)       1 (2%)       1 (2%)                                             
      Degeneration, Multifocal                         2 (4%)       4 (8%)       7 (14%)                                            
      Hemorrhage, Multifocal                           2 (4%)       1 (2%)       2 (4%)                                             
      Necrosis, Focal                                                            1 (2%)                                             
      Thrombosis                                                                 1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   12                                                              
NTP Experiment-Test: 05048-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            RHODAMINE 6G                                       Date: 09/06/94  
Route: DOSED FEED                                                                                                 Time: 23:49:35  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     UNTREATD     0.012%       0.025%                                                 
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)                                                
      Congestion                                       1 (2%)       3 (6%)       1 (2%)                                             
      Cyst                                             1 (2%)                                                                       
      Foreign Body                                                               1 (2%)                                             
      Granuloma                                                                  1 (2%)                                             
      Hemorrhage, Multifocal                           2 (4%)       1 (2%)                                                          
      Hyperplasia, Histiocytic                                      1 (2%)                                                          
      Inflammation, Multifocal, Subacute                            1 (2%)       1 (2%)                                             
      Mineralization                                   1 (2%)       1 (2%)                                                          
      Alveolar Epithelium, Hyperplasia, Focal          1 (2%)       2 (4%)       1 (2%)                                             
   Nose                                               (50)         (50)         (45)                                                
      Foreign Body                                     3 (6%)       8 (16%)      7 (16%)                                            
      Fungus                                          11 (22%)     20 (40%)     10 (22%)                                            
      Hemorrhage                                                                 2 (4%)                                             
      Inflammation, Acute, Suppurative                14 (28%)     20 (40%)     14 (31%)                                            
      Inflammation, Chronic                                                      1 (2%)                                             
      Nasolacrimal Duct, Inflammation, Acute,                                                                                       
          Suppurative                                  3 (6%)       1 (2%)       1 (2%)                                             
   Trachea                                            (50)         (49)         (50)                                                
      Inflammation, Subacute                                                     1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (4)          (8)          (18)                                                
      Cataract                                         1 (25%)      3 (38%)     13 (72%)                                            
      Hemorrhage                                                    1 (13%)      2 (11%)                                            
      Synechia                                         1 (25%)                                                                      
      Cornea, Inflammation, Chronic                    1 (25%)                                                                      
      Cornea, Inflammation, Diffuse, Subacute                       1 (13%)                                                         
      Cornea, Inflammation, Focal, Subacute                         1 (13%)                                                         
      Retina, Degeneration                             1 (25%)      6 (75%)     17 (94%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)                                                
      Bacterium                                                     1 (2%)                                                          
      Fibrosis, Focal                                               1 (2%)                                                          
      Hydronephrosis                                                             1 (2%)                                             
      Inflammation, Acute, Suppurative                              1 (2%)       1 (2%)                                             
      Inflammation, Chronic, Focal                                  1 (2%)                                                          
      Nephropathy, Chronic                            49 (98%)     48 (96%)     49 (98%)                                            
      Pigmentation, Hemosiderin                                     1 (2%)                                                          
      Cortex, Cyst                                     3 (6%)       2 (4%)       2 (4%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   13                                                              
NTP Experiment-Test: 05048-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            RHODAMINE 6G                                       Date: 09/06/94  
Route: DOSED FEED                                                                                                 Time: 23:49:35  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     UNTREATD     0.012%       0.025%                                                 
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Cortex, Mineralization                           1 (2%)       2 (4%)       2 (4%)                                             
      Cortex, Necrosis, Focal                                       1 (2%)                                                          
      Papilla, Necrosis                                                          1 (2%)                                             
      Pelvis, Inflammation, Acute, Suppurative                                   1 (2%)                                             
   Urinary Bladder                                    (50)         (49)         (50)                                                
      Hemorrhage                                                                 1 (2%)                                             
      Inflammation, Acute, Suppurative                                           1 (2%)                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   14                                                              
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NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.