TR 364 Rat Pathology Tables
INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
RHODAMINE 6G
NTP Experiment-Test: 05048-01 Report: PEIRPT03
Study Type: CHRONIC Date: 09/06/94
Route: DOSED FEED Time: 23:49:35
Facility: Southern Research Institute
Chemical CAS #: 989-38-8
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05048-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC RHODAMINE 6G Date: 09/06/94
Route: DOSED FEED Time: 23:49:35
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE UNTREATD 0.012% 0.025%
CONTROL
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50
Early Deaths
Moribund 17 16 18
Dead 4 4 2
Survivors
Terminal Sacrifice 29 30 30
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large (50) (49) (50)
Cecum, Parasite Metazoan 2 (4%)
Colon, Parasite Metazoan 2 (4%) 2 (4%)
Rectum, Parasite Metazoan 1 (2%) 1 (2%)
Liver (50) (49) (50)
Angiectasis, Focal 1 (2%) 1 (2%) 1 (2%)
Basophilic Focus 11 (22%) 8 (16%) 5 (10%)
Basophilic Focus, Multiple 18 (36%) 22 (45%) 28 (56%)
Clear Cell Focus 2 (4%)
Congestion, Diffuse 1 (2%)
Developmental Malformation 4 (8%) 4 (8%) 3 (6%)
Granuloma 1 (2%) 1 (2%) 1 (2%)
Granuloma, Multifocal 17 (34%) 18 (37%) 16 (32%)
Hematopoietic Cell Proliferation, Multifocal 1 (2%) 2 (4%)
Hemorrhage, Multifocal 1 (2%)
Hepatodiaphragmatic Nodule 2 (4%) 3 (6%)
Mixed Cell Focus 1 (2%)
Necrosis, Focal 1 (2%) 1 (2%) 1 (2%)
Necrosis, Multifocal 2 (4%) 2 (4%)
Pigmentation, Hemosiderin, Multifocal 1 (2%)
Thrombosis, Multiple 1 (2%)
Vacuolization Cytoplasmic, Diffuse 6 (12%) 8 (16%) 7 (14%)
Vacuolization Cytoplasmic, Focal 2 (4%) 1 (2%)
Biliary Tract, Hyperplasia 14 (28%) 19 (39%) 13 (26%)
Centrilobular, Necrosis 7 (14%) 6 (12%) 7 (14%)
Hepatocyte, Hypertrophy 5 (10%) 6 (12%) 4 (8%)
Mesentery (2) (2) (9)
Inflammation, Chronic, Focal 1 (50%)
Fat, Necrosis, Focal 1 (50%) 2 (100%) 9 (100%)
Pancreas (48) (49) (50)
Atrophy 7 (15%) 9 (18%) 8 (16%)
Inflammation, Focal, Subacute 1 (2%)
Artery, Inflammation, Subacute 1 (2%)
Salivary Glands (50) (49) (49)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05048-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC RHODAMINE 6G Date: 09/06/94
Route: DOSED FEED Time: 23:49:35
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE UNTREATD 0.012% 0.025%
CONTROL
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Inflammation, Multifocal, Subacute 1 (2%)
Duct, Cyst 1 (2%) 2 (4%)
Stomach (50) (50) (50)
Artery, Inflammation, Subacute 1 (2%)
Forestomach, Edema 1 (2%) 4 (8%)
Forestomach, Hyperkeratosis 3 (6%) 5 (10%) 2 (4%)
Forestomach, Hyperplasia 3 (6%) 5 (10%) 3 (6%)
Forestomach, Inflammation, Subacute 4 (8%) 4 (8%)
Forestomach, Perforation 2 (4%)
Forestomach, Ulcer 2 (4%) 4 (8%) 4 (8%)
Forestomach, Ulcer, Multiple 1 (2%) 1 (2%)
Glandular, Edema 1 (2%)
Glandular, Erosion 1 (2%) 1 (2%)
Glandular, Inflammation, Subacute 2 (4%) 1 (2%)
Glandular, Mineralization 1 (2%)
Glandular, Ulcer 1 (2%) 1 (2%)
Tooth (1)
Inflammation, Acute, Suppurative 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50)
Fibrosis, Multifocal 16 (32%) 26 (52%) 22 (44%)
Atrium, Mineralization, Focal 1 (2%)
Atrium, Pigmentation, Hemosiderin 1 (2%)
Atrium, Thrombosis 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland (50) (50) (50)
Accessory Adrenal Cortical Nodule 1 (2%)
Cortex, Angiectasis, Focal 1 (2%) 1 (2%)
Cortex, Angiectasis, Multifocal 1 (2%) 1 (2%)
Cortex, Congestion, Diffuse 1 (2%) 1 (2%)
Cortex, Degeneration, Fatty, Focal 5 (10%) 13 (26%) 7 (14%)
Cortex, Degeneration, Fatty, Multifocal 2 (4%) 4 (8%) 5 (10%)
Cortex, Hyperplasia, Focal 1 (2%) 2 (4%) 2 (4%)
Cortex, Hypertrophy, Focal 1 (2%)
Cortex, Necrosis, Focal 1 (2%)
Medulla, Hyperplasia, Focal 4 (8%) 6 (12%) 8 (16%)
Parathyroid Gland (46) (48) (46)
Hyperplasia 1 (2%)
Pituitary Gland (49) (49) (50)
Hemorrhage, Focal 1 (2%) 1 (2%)
Pars Distalis, Angiectasis 34 (69%) 30 (61%) 30 (60%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05048-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC RHODAMINE 6G Date: 09/06/94
Route: DOSED FEED Time: 23:49:35
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE UNTREATD 0.012% 0.025%
CONTROL
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Pars Distalis, Cyst 11 (22%) 18 (37%) 8 (16%)
Pars Distalis, Hyperplasia, Focal 7 (14%) 7 (14%) 9 (18%)
Pars Distalis, Pigmentation, Hemosiderin 25 (51%) 17 (35%) 15 (30%)
Thyroid Gland (50) (50) (50)
C-Cell, Hyperplasia, Focal 3 (6%) 1 (2%) 5 (10%)
C-Cell, Hyperplasia, Multifocal 1 (2%) 2 (4%) 1 (2%)
Follicle, Cyst 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (42) (40) (39)
Cyst 5 (12%) 2 (5%) 4 (10%)
Inflammation, Acute, Suppurative 1 (2%) 4 (10%) 3 (8%)
Inflammation, Focal, Subacute 3 (7%) 1 (3%) 1 (3%)
Ovary (50) (49) (50)
Cyst 2 (4%) 5 (10%) 6 (12%)
Uterus (49) (50) (50)
Hemorrhage, Focal 1 (2%) 1 (2%)
Hydrometra 2 (4%) 1 (2%)
Inflammation, Acute, Suppurative 2 (4%)
Necrosis 2 (4%)
Cervix, Abscess 5 (10%) 5 (10%)
Cervix, Cyst 2 (4%) 5 (10%) 3 (6%)
Cervix, Necrosis 1 (2%)
Endometrium, Hyperplasia, Cystic 1 (2%)
Mucosa, Cyst 1 (2%) 1 (2%)
Vagina (1)
Abscess 1 (100%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50)
Hyperplasia 3 (6%) 2 (4%)
Lymph Node (50) (49) (50)
Deep Cervical, Congestion 1 (2%)
Inguinal, Hyperplasia 1 (2%) 1 (2%)
Mandibular, Ectasia 2 (4%) 1 (2%)
Mandibular, Hyperplasia 1 (2%)
Mesenteric, Congestion 1 (2%)
Spleen (49) (49) (50)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05048-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC RHODAMINE 6G Date: 09/06/94
Route: DOSED FEED Time: 23:49:35
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE UNTREATD 0.012% 0.025%
CONTROL
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Congestion 1 (2%)
Fibrosis, Focal 1 (2%)
Hematopoietic Cell Proliferation 7 (14%) 5 (10%) 5 (10%)
Hyperplasia, Focal, Lymphoid 1 (2%)
Necrosis, Focal 1 (2%)
Thymus (43) (46) (49)
Cyst 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (50) (50)
Hemorrhage 1 (2%) 1 (2%)
Hyperplasia, Glandular 1 (2%) 3 (6%) 1 (2%)
Duct, Cyst 47 (94%) 44 (88%) 42 (84%)
Duct, Cyst, Multiple 1 (2%)
Skin (50) (50) (50)
Cyst Epithelial Inclusion 1 (2%)
Foreign Body 3 (6%)
Hyperkeratosis, Focal 1 (2%)
Hyperplasia 1 (2%)
Hyperplasia, Focal 1 (2%)
Inflammation, Acute, Focal, Suppurative 1 (2%) 2 (4%) 1 (2%)
Inflammation, Focal, Subacute 1 (2%)
Inflammation, Granulomatous, Multifocal 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50)
Cranium, Hyperostosis, Focal 1 (2%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50)
Compression 4 (8%) 4 (8%) 3 (6%)
Degeneration, Multifocal 2 (4%) 7 (14%)
Hemorrhage, Multifocal 1 (2%) 2 (4%)
Mineralization, Focal 1 (2%)
Necrosis, Multifocal 1 (2%)
Cerebellum, Mineralization, Multifocal 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05048-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC RHODAMINE 6G Date: 09/06/94
Route: DOSED FEED Time: 23:49:35
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE UNTREATD 0.012% 0.025%
CONTROL
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50)
Atelectasis, Multifocal 1 (2%)
Congestion 1 (2%)
Foreign Body, Multiple 1 (2%)
Granuloma, Multifocal 1 (2%)
Hemorrhage, Multifocal 2 (4%)
Hyperplasia, Macrophage 1 (2%)
Metaplasia, Multifocal, Osseous 1 (2%)
Pigmentation, Hemosiderin 1 (2%) 1 (2%)
Alveolar Epithelium, Hyperplasia, Focal 1 (2%)
Nose (49) (50) (47)
Foreign Body 1 (2%)
Fungus 2 (4%) 1 (2%)
Inflammation, Acute, Suppurative 2 (4%) 3 (6%) 2 (4%)
Inflammation, Granulomatous 1 (2%)
Nasolacrimal Duct, Foreign Body 1 (2%)
Nasolacrimal Duct, Inflammation, Acute,
Suppurative 3 (6%) 1 (2%) 2 (4%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Ear (4) (11) (12)
Inflammation, Acute, Suppurative 1 (8%)
Eye (2) (21) (6)
Cataract 1 (50%) 21 (100%) 3 (50%)
Hemorrhage 1 (50%)
Cornea, Inflammation, Chronic 2 (33%)
Retina, Degeneration 2 (100%) 21 (100%) 5 (83%)
Lacrimal Gland (1) (3) (1)
Ectopic Harderian 1 (100%) 3 (100%) 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50)
Nephropathy, Chronic 39 (78%) 37 (74%) 36 (72%)
Cortex, Cyst 1 (2%)
Cortex, Inflammation, Acute, Multifocal,
Suppurative 1 (2%)
Medulla, Mineralization, Focal 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05048-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC RHODAMINE 6G Date: 09/06/94
Route: DOSED FEED Time: 23:49:35
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE UNTREATD 0.012% 0.025%
CONTROL
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Right, Hydronephrosis 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 05048-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC RHODAMINE 6G Date: 09/06/94
Route: DOSED FEED Time: 23:49:35
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE UNTREATD 0.012% 0.025%
CONTROL
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50
Early Deaths
Moribund 23 25 19
Dead 5 4 4
Survivors
Terminal Sacrifice 22 20 27
Dead 1
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large (50) (49) (50)
Cecum, Inflammation, Subacute 2 (4%)
Cecum, Parasite Metazoan 1 (2%)
Colon, Cyst 1 (2%)
Colon, Diverticulum 1 (2%)
Colon, Edema 1 (2%)
Colon, Parasite Metazoan 6 (12%) 5 (10%) 1 (2%)
Rectum, Mineralization 1 (2%) 1 (2%)
Rectum, Parasite Metazoan 1 (2%) 4 (8%)
Intestine Small (50) (49) (50)
Peyer's Patch, Mineralization, Focal 1 (2%)
Peyer's Patch, Necrosis, Focal 1 (2%)
Liver (50) (50) (50)
Angiectasis, Focal 7 (14%) 6 (12%) 8 (16%)
Angiectasis, Multifocal 8 (16%) 2 (4%) 6 (12%)
Basophilic Focus 2 (4%) 4 (8%) 5 (10%)
Basophilic Focus, Multiple 3 (6%) 1 (2%) 2 (4%)
Clear Cell Focus 1 (2%)
Congestion 3 (6%)
Degeneration, Fatty, Focal 1 (2%)
Developmental Malformation 5 (10%) 1 (2%) 5 (10%)
Eosinophilic Focus 2 (4%)
Eosinophilic Focus, Multiple 1 (2%)
Fibrosis, Focal 1 (2%)
Granuloma, Focal 1 (2%)
Granuloma, Multifocal 2 (4%) 2 (4%) 2 (4%)
Hematopoietic Cell Proliferation 1 (2%)
Hemorrhage, Focal 1 (2%)
Hemorrhage, Multifocal 1 (2%)
Hepatodiaphragmatic Nodule 1 (2%)
Necrosis, Focal 1 (2%)
Necrosis, Multifocal 1 (2%) 1 (2%) 1 (2%)
Pigmentation, Focal, Hemosiderin 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 05048-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC RHODAMINE 6G Date: 09/06/94
Route: DOSED FEED Time: 23:49:35
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE UNTREATD 0.012% 0.025%
CONTROL
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Pigmentation, Hemosiderin, Multifocal 1 (2%)
Thrombosis 1 (2%)
Vacuolization Cytoplasmic, Diffuse 3 (6%) 3 (6%) 5 (10%)
Vacuolization Cytoplasmic, Focal 1 (2%) 3 (6%)
Vacuolization Cytoplasmic, Multifocal 1 (2%) 1 (2%)
Biliary Tract, Hyperplasia 32 (64%) 37 (74%) 39 (78%)
Centrilobular, Necrosis 12 (24%) 19 (38%) 13 (26%)
Hepatocyte, Hypertrophy 1 (2%) 8 (16%) 4 (8%)
Mesentery (2) (4) (4)
Hemorrhage 2 (50%)
Inflammation, Diffuse, Subacute 1 (25%)
Fat, Necrosis, Focal 2 (100%) 2 (50%) 2 (50%)
Pancreas (50) (49) (50)
Atrophy 9 (18%) 18 (37%) 11 (22%)
Acinus, Hyperplasia 1 (2%)
Artery, Hypertrophy 1 (2%)
Artery, Inflammation, Subacute 3 (6%) 2 (4%) 1 (2%)
Salivary Glands (50) (49) (50)
Infiltration Cellular, Multifocal, Lymphocyte 1 (2%)
Stomach (49) (50) (50)
Inflammation, Subacute 1 (2%)
Artery, Inflammation, Subacute 1 (2%) 1 (2%)
Forestomach, Edema 1 (2%)
Forestomach, Foreign Body 1 (2%)
Forestomach, Hyperkeratosis 1 (2%) 2 (4%) 4 (8%)
Forestomach, Hyperplasia 1 (2%) 2 (4%) 4 (8%)
Forestomach, Inflammation, Focal,
Granulomatous 1 (2%)
Forestomach, Inflammation, Subacute 2 (4%) 2 (4%) 2 (4%)
Forestomach, Mineralization 1 (2%) 2 (4%)
Forestomach, Ulcer 3 (6%) 1 (2%) 1 (2%)
Glandular, Edema 1 (2%)
Glandular, Erosion 1 (2%) 1 (2%)
Glandular, Erosion, Multiple 1 (2%)
Glandular, Mineralization 1 (2%) 5 (10%) 1 (2%)
Glandular, Ulcer 1 (2%)
Glandular, Ulcer, Multiple 1 (2%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (1) (2) (1)
Mineralization 1 (100%) 2 (100%) 1 (100%)
Heart (50) (50) (50)
Bacterium 1 (2%)
Fibrosis, Multifocal 35 (70%) 40 (80%) 40 (80%)
Inflammation, Acute, Suppurative 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 05048-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC RHODAMINE 6G Date: 09/06/94
Route: DOSED FEED Time: 23:49:35
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE UNTREATD 0.012% 0.025%
CONTROL
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - CONT
Mineralization 1 (2%) 2 (4%) 1 (2%)
Atrium, Thrombosis 3 (6%) 3 (6%) 2 (4%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland (50) (49) (50)
Hyperplasia, Focal 1 (2%)
Cortex, Angiectasis, Focal 2 (4%)
Cortex, Congestion 1 (2%)
Cortex, Degeneration, Diffuse, Fatty 1 (2%)
Cortex, Degeneration, Fatty, Focal 1 (2%) 5 (10%) 6 (12%)
Cortex, Degeneration, Fatty, Multifocal 2 (4%) 1 (2%)
Cortex, Hemorrhage, Multifocal 1 (2%)
Cortex, Hyperplasia, Focal 2 (4%)
Cortex, Hyperplasia, Multifocal 1 (2%)
Cortex, Hyperplasia, Multifocal, Multifocal 1 (2%)
Cortex, Necrosis, Diffuse 1 (2%)
Cortex, Necrosis, Multifocal 2 (4%)
Medulla, Hematopoietic Cell Proliferation 1 (2%) 2 (4%)
Medulla, Hyperplasia, Focal 6 (12%) 10 (20%) 2 (4%)
Medulla, Hyperplasia, Multifocal 1 (2%) 1 (2%) 1 (2%)
Medulla, Necrosis, Diffuse 1 (2%)
Medulla, Necrosis, Multifocal 1 (2%)
Islets, Pancreatic (50) (49) (50)
Hyperplasia 1 (2%) 1 (2%)
Parathyroid Gland (47) (46) (48)
Hyperplasia 4 (9%) 4 (9%) 3 (6%)
Pituitary Gland (49) (49) (49)
Pars Distalis, Angiectasis 6 (12%) 5 (10%) 11 (22%)
Pars Distalis, Cyst 2 (4%) 1 (2%) 1 (2%)
Pars Distalis, Hemorrhage, Focal 1 (2%) 1 (2%)
Pars Distalis, Hyperplasia, Focal 2 (4%) 5 (10%) 2 (4%)
Pars Distalis, Pigmentation, Hemosiderin 4 (8%) 2 (4%) 7 (14%)
Thyroid Gland (50) (48) (50)
Ultimobranchial Cyst 1 (2%) 2 (4%) 1 (2%)
C-Cell, Hyperplasia, Focal 1 (2%) 2 (4%) 1 (2%)
C-Cell, Hyperplasia, Multifocal 1 (2%) 1 (2%)
Follicle, Cyst 2 (4%) 1 (2%) 1 (2%)
Follicle, Hyperplasia, Cystic, Focal 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 05048-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC RHODAMINE 6G Date: 09/06/94
Route: DOSED FEED Time: 23:49:35
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE UNTREATD 0.012% 0.025%
CONTROL
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Preputial Gland (49) (48) (43)
Hyperplasia 1 (2%)
Inflammation, Acute, Suppurative 4 (8%) 8 (17%) 6 (14%)
Inflammation, Chronic 1 (2%)
Inflammation, Subacute 2 (4%) 1 (2%)
Duct, Cyst 3 (6%) 6 (13%) 3 (7%)
Prostate (50) (49) (50)
Concretion 1 (2%)
Cyst 1 (2%)
Edema 1 (2%)
Fibrosis 1 (2%)
Hemorrhage 1 (2%)
Inflammation, Acute, Suppurative 19 (38%) 16 (33%) 19 (38%)
Inflammation, Chronic 5 (10%) 1 (2%) 1 (2%)
Inflammation, Subacute 3 (6%) 1 (2%)
Seminal Vesicle (4) (2)
Inflammation, Acute, Suppurative 1 (50%)
Inflammation, Chronic 1 (25%)
Testes (49) (50) (50)
Angiectasis 1 (2%)
Atrophy 2 (4%) 2 (4%) 4 (8%)
Inflammation, Acute, Suppurative 1 (2%)
Mineralization 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50)
Hyperplasia 1 (2%) 2 (4%)
Lymph Node (50) (49) (50)
Deep Cervical, Congestion 1 (2%)
Iliac, Ectasia 1 (2%)
Inguinal, Hyperplasia 1 (2%)
Lumbar, Ectasia 2 (4%)
Mandibular, Congestion 1 (2%)
Mandibular, Ectasia 7 (14%) 7 (14%) 6 (12%)
Mediastinal, Congestion 1 (2%)
Mediastinal, Hyperplasia 1 (2%)
Mesenteric, Angiectasis 2 (4%) 1 (2%)
Mesenteric, Congestion 1 (2%)
Mesenteric, Ectasia 2 (4%) 5 (10%) 4 (8%)
Pancreatic, Ectasia 1 (2%) 1 (2%)
Pancreatic, Hyperplasia 1 (2%)
Spleen (50) (50) (50)
Atrophy 2 (4%) 1 (2%)
Congestion 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 05048-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC RHODAMINE 6G Date: 09/06/94
Route: DOSED FEED Time: 23:49:35
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE UNTREATD 0.012% 0.025%
CONTROL
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Developmental Malformation 1 (2%)
Fibrosis 7 (14%) 7 (14%) 7 (14%)
Hematopoietic Cell Proliferation 1 (2%) 4 (8%) 5 (10%)
Inflammation, Acute, Suppurative 1 (2%)
Necrosis, Focal 1 (2%) 1 (2%)
Pigmentation, Hemosiderin 1 (2%)
Capsule, Fibrosis, Focal 1 (2%)
Thymus (47) (47) (47)
Cyst 1 (2%) 1 (2%)
Mediastinum, Inflammation, Acute, Suppurative 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (49) (46)
Granuloma 1 (2%)
Inflammation, Chronic, Focal 1 (2%)
Pigmentation, Hemosiderin 1 (2%)
Duct, Cyst 10 (20%) 18 (37%) 22 (48%)
Skin (50) (50) (50)
Abscess 1 (2%)
Alopecia 1 (2%)
Cyst Epithelial Inclusion 1 (2%) 2 (4%)
Hyperkeratosis, Focal 1 (2%) 1 (2%) 1 (2%)
Hyperplasia 1 (2%)
Hyperplasia, Focal 1 (2%) 1 (2%) 2 (4%)
Inflammation, Acute, Focal, Suppurative 2 (4%) 2 (4%) 1 (2%)
Inflammation, Chronic, Focal 1 (2%) 1 (2%)
Inflammation, Focal, Granulomatous 1 (2%) 1 (2%)
Inflammation, Focal, Subacute 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50)
Fibrous Osteodystrophy 3 (6%) 3 (6%) 2 (4%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50)
Bacterium 1 (2%)
Compression 1 (2%) 1 (2%) 1 (2%)
Degeneration, Multifocal 2 (4%) 4 (8%) 7 (14%)
Hemorrhage, Multifocal 2 (4%) 1 (2%) 2 (4%)
Necrosis, Focal 1 (2%)
Thrombosis 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 12
NTP Experiment-Test: 05048-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC RHODAMINE 6G Date: 09/06/94
Route: DOSED FEED Time: 23:49:35
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE UNTREATD 0.012% 0.025%
CONTROL
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50)
Congestion 1 (2%) 3 (6%) 1 (2%)
Cyst 1 (2%)
Foreign Body 1 (2%)
Granuloma 1 (2%)
Hemorrhage, Multifocal 2 (4%) 1 (2%)
Hyperplasia, Histiocytic 1 (2%)
Inflammation, Multifocal, Subacute 1 (2%) 1 (2%)
Mineralization 1 (2%) 1 (2%)
Alveolar Epithelium, Hyperplasia, Focal 1 (2%) 2 (4%) 1 (2%)
Nose (50) (50) (45)
Foreign Body 3 (6%) 8 (16%) 7 (16%)
Fungus 11 (22%) 20 (40%) 10 (22%)
Hemorrhage 2 (4%)
Inflammation, Acute, Suppurative 14 (28%) 20 (40%) 14 (31%)
Inflammation, Chronic 1 (2%)
Nasolacrimal Duct, Inflammation, Acute,
Suppurative 3 (6%) 1 (2%) 1 (2%)
Trachea (50) (49) (50)
Inflammation, Subacute 1 (2%)
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SPECIAL SENSES SYSTEM
Eye (4) (8) (18)
Cataract 1 (25%) 3 (38%) 13 (72%)
Hemorrhage 1 (13%) 2 (11%)
Synechia 1 (25%)
Cornea, Inflammation, Chronic 1 (25%)
Cornea, Inflammation, Diffuse, Subacute 1 (13%)
Cornea, Inflammation, Focal, Subacute 1 (13%)
Retina, Degeneration 1 (25%) 6 (75%) 17 (94%)
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URINARY SYSTEM
Kidney (50) (50) (50)
Bacterium 1 (2%)
Fibrosis, Focal 1 (2%)
Hydronephrosis 1 (2%)
Inflammation, Acute, Suppurative 1 (2%) 1 (2%)
Inflammation, Chronic, Focal 1 (2%)
Nephropathy, Chronic 49 (98%) 48 (96%) 49 (98%)
Pigmentation, Hemosiderin 1 (2%)
Cortex, Cyst 3 (6%) 2 (4%) 2 (4%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 13
NTP Experiment-Test: 05048-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC RHODAMINE 6G Date: 09/06/94
Route: DOSED FEED Time: 23:49:35
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FISCHER 344 RATS MALE UNTREATD 0.012% 0.025%
CONTROL
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Cortex, Mineralization 1 (2%) 2 (4%) 2 (4%)
Cortex, Necrosis, Focal 1 (2%)
Papilla, Necrosis 1 (2%)
Pelvis, Inflammation, Acute, Suppurative 1 (2%)
Urinary Bladder (50) (49) (50)
Hemorrhage 1 (2%)
Inflammation, Acute, Suppurative 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
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