National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/1329

TR 364 Rat Pathology Tables


                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                            RHODAMINE 6G


NTP Experiment-Test: 05048-01                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 09/06/94
Route: DOSED FEED                                                                                                 Time: 23:53:03




       Facility:  Southern Research Institute

       Chemical CAS #:  989-38-8

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05048-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            RHODAMINE 6G                                       Date: 09/06/94  
Route: DOSED FEED                                                                                                 Time: 23:53:03  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   UNTREATD     0.012%       0.025%                                                 
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Moribund                                          17           16           18                                                  
    Dead                                               4            4            2                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                29           30           30                                                  
  Animals Examined Microscopically                    50           50           50                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Small                                    (50)         (49)         (50)                                                
   Liver                                              (50)         (49)         (50)                                                
      Neoplastic Nodule                                             1 (2%)                                                          
      Sarcoma                                                                    1 (2%)                                             
   Pancreas                                           (48)         (49)         (50)                                                
      Adenoma                                          1 (2%)                                                                       
   Salivary Glands                                    (50)         (49)         (49)                                                
   Stomach                                            (50)         (50)         (50)                                                
   Tongue                                                                       (1)                                                 
      Squamous Cell Papilloma                                                    1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (50)         (50)         (50)                                                
      Osteosarcoma, Metastatic, Bone                                1 (2%)                                                          
      Sarcoma Stromal, Metastatic, Uterus                           1 (2%)                                                          
      Cortex, Adenoma                                  1 (2%)       3 (6%)                                                          
      Medulla, Pheochromocytoma Malignant                                        2 (4%)                                             
      Medulla, Pheochromocytoma Benign                 3 (6%)       3 (6%)       7 (14%)                                            
      Medulla, Pheochromocytoma Benign, Multiple                                 1 (2%)                                             
   Islets, Pancreatic                                 (48)         (49)         (50)                                                
      Adenoma                                          2 (4%)                                                                       
      Carcinoma                                        1 (2%)                    1 (2%)                                             
   Parathyroid Gland                                  (46)         (48)         (46)                                                
      Adenoma                                                       1 (2%)                                                          
   Pituitary Gland                                    (49)         (49)         (50)                                                
      Pars Distalis, Adenoma                          31 (63%)     29 (59%)     28 (56%)                                            
                                                             Page   2                                                               
NTP Experiment-Test: 05048-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            RHODAMINE 6G                                       Date: 09/06/94  
Route: DOSED FEED                                                                                                 Time: 23:53:03  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   UNTREATD     0.012%       0.025%                                                 
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - cont                                                                                                             
      Pars Intermedia, Adenoma                                                   1 (2%)                                             
   Thyroid Gland                                      (50)         (50)         (50)                                                
      C-Cell, Adenoma                                  4 (8%)       3 (6%)       4 (8%)                                             
      C-Cell, Carcinoma                                             1 (2%)       2 (4%)                                             
      Follicular Cell, Adenoma                         1 (2%)                                                                       
      Follicular Cell, Carcinoma                                                 1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (42)         (40)         (39)                                                
      Adenoma                                          5 (12%)      4 (10%)      2 (5%)                                             
      Carcinoma                                        1 (2%)       4 (10%)      3 (8%)                                             
      Sarcoma                                                                    1 (3%)                                             
      Squamous Cell Papilloma                          1 (2%)                                                                       
   Ovary                                              (50)         (49)         (50)                                                
      Sarcoma                                                                    1 (2%)                                             
   Uterus                                             (49)         (50)         (50)                                                
      Adenocarcinoma                                   1 (2%)       1 (2%)                                                          
      Leiomyoma                                                                  1 (2%)                                             
      Polyp Stromal                                    7 (14%)     12 (24%)     13 (26%)                                            
      Sarcoma                                                                    1 (2%)                                             
      Sarcoma Stromal                                  3 (6%)       1 (2%)                                                          
      Cervix, Leiomyoma                                             1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Blood                                              (43)         (42)         (48)                                                
   Bone Marrow                                        (50)         (50)         (50)                                                
      Sarcoma                                                                    1 (2%)                                             
   Lymph Node                                         (50)         (49)         (50)                                                
   Spleen                                             (49)         (49)         (50)                                                
   Thymus                                             (43)         (46)         (49)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (50)         (50)                                                
      Adenocarcinoma                                   3 (6%)       1 (2%)       2 (4%)                                             
      Adenoma                                          1 (2%)                                                                       
      Fibroadenoma                                    12 (24%)     12 (24%)     11 (22%)                                            
                                                             Page   3                                                               
NTP Experiment-Test: 05048-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            RHODAMINE 6G                                       Date: 09/06/94  
Route: DOSED FEED                                                                                                 Time: 23:53:03  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   UNTREATD     0.012%       0.025%                                                 
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - cont                                                                                                         
      Fibroadenoma, Multiple                           7 (14%)      3 (6%)       6 (12%)                                            
      Sarcoma                                                                    1 (2%)                                             
   Skin                                               (50)         (50)         (50)                                                
      Basal Cell Adenoma                               1 (2%)                    1 (2%)                                             
      Keratoacanthoma                                  1 (2%)       1 (2%)                                                          
      Squamous Cell Papilloma                                                    1 (2%)                                             
      Subcutaneous Tissue, Fibroma                                  2 (4%)                                                          
      Subcutaneous Tissue, Lipoma                                                1 (2%)                                             
      Subcutaneous Tissue, Sarcoma                                               1 (2%)                                             
      Subcutaneous Tissue, Schwannoma Benign                                     1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)                                                
      Osteosarcoma                                     1 (2%)       1 (2%)                                                          
   Skeletal Muscle                                    (1)                                                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)                                                
      Astrocytoma Malignant                                                      1 (2%)                                             
      Glioma Malignant                                              1 (2%)                                                          
      Sarcoma                                                                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)                                                
      Osteosarcoma, Metastatic, Bone                                1 (2%)                                                          
      Sarcoma                                                                    2 (4%)                                             
   Nose                                               (49)         (50)         (47)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Zymbal's Gland                                     (1)                                                                           
      Carcinoma                                        1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)                                                
      Renal Tubule, Carcinoma                                                    1 (2%)                                             
   Urinary Bladder                                    (50)         (50)         (50)                                                
                                                             Page   4                                                               
NTP Experiment-Test: 05048-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            RHODAMINE 6G                                       Date: 09/06/94  
Route: DOSED FEED                                                                                                 Time: 23:53:03  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   UNTREATD     0.012%       0.025%                                                 
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - cont                                                                                                               
      Transitional Epithelium, Papilloma                                         1 (2%)                                             
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)                                                
      Leukemia Mononuclear                            11 (22%)     11 (22%)     10 (20%)                                            
      Lymphoma Malignant Histiocytic                                1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   5                                                               
NTP Experiment-Test: 05048-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            RHODAMINE 6G                                       Date: 09/06/94  
Route: DOSED FEED                                                                                                 Time: 23:53:03  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   UNTREATD     0.012%       0.025%                                                 
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            48          47          49                                                   
     Total Primary Neoplasms                          100          97         113                                                   
                                                                                                                                    
   Total Animals with Benign Neoplasms                 43          41          46                                                   
     Total Benign Neoplasms                            78          75          80                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms              21          22          20                                                   
     Total Malignant Neoplasms                         22          22          33                                                   
                                                                                                                                    
   Total Animals with Metastatic Neoplasms                          2                                                               
     Total Metastatic Neoplasm                                      3                                                               
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   6                                                               
NTP Experiment-Test: 05048-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            RHODAMINE 6G                                       Date: 09/06/94  
Route: DOSED FEED                                                                                                 Time: 23:53:03  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     UNTREATD     0.012%       0.025%                                                 
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Moribund                                          23           25           19                                                  
    Dead                                               5            4            4                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                22           20           27                                                  
    Dead                                                            1                                                               
  Animals Examined Microscopically                    50           50           50                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large                                    (50)         (49)         (50)                                                
   Intestine Small                                    (50)         (49)         (50)                                                
      Ileum, Polyp Adenomatous                                      1 (2%)                                                          
   Liver                                              (50)         (50)         (50)                                                
      Hepatocellular Carcinoma                         1 (2%)                    1 (2%)                                             
      Neoplastic Nodule                                3 (6%)                    4 (8%)                                             
      Neoplastic Nodule, Multiple                      1 (2%)                    2 (4%)                                             
   Mesentery                                          (2)          (4)          (4)                                                 
      Sarcoma                                                                    1 (25%)                                            
   Pancreas                                           (50)         (49)         (50)                                                
      Adenoma                                                       1 (2%)                                                          
      Acinus, Adenoma                                  2 (4%)       4 (8%)                                                          
      Acinus, Adenoma, Multiple                                     1 (2%)                                                          
   Salivary Glands                                    (50)         (49)         (50)                                                
   Stomach                                            (49)         (50)         (50)                                                
      Squamous Cell Papilloma                                       1 (2%)                                                          
      Serosa, Sarcoma                                                            1 (2%)                                             
   Tongue                                                                       (2)                                                 
      Squamous Cell Papilloma                                                    1 (50%)                                            
   Tooth                                                                        (1)                                                 
      Neoplasm NOS                                                               1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   7                                                               
NTP Experiment-Test: 05048-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            RHODAMINE 6G                                       Date: 09/06/94  
Route: DOSED FEED                                                                                                 Time: 23:53:03  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     UNTREATD     0.012%       0.025%                                                 
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (50)         (49)         (50)                                                
      Cortex, Adenoma                                  1 (2%)                                                                       
      Medulla, Pheochromocytoma Malignant              9 (18%)      8 (16%)      5 (10%)                                            
      Medulla, Pheochromocytoma Malignant, Multiple    1 (2%)                                                                       
      Medulla, Pheochromocytoma Benign                14 (28%)     21 (43%)     19 (38%)                                            
      Medulla, Pheochromocytoma Benign, Multiple       4 (8%)       4 (8%)       4 (8%)                                             
   Islets, Pancreatic                                 (50)         (49)         (50)                                                
      Adenoma                                          1 (2%)       2 (4%)       4 (8%)                                             
      Adenoma, Multiple                                             1 (2%)                                                          
      Carcinoma                                        1 (2%)       1 (2%)       1 (2%)                                             
   Pituitary Gland                                    (49)         (49)         (49)                                                
      Pars Distalis, Adenoma                           9 (18%)      8 (16%)     12 (24%)                                            
   Thyroid Gland                                      (50)         (48)         (50)                                                
      C-Cell, Adenoma                                  5 (10%)      6 (13%)      1 (2%)                                             
      C-Cell, Carcinoma                                3 (6%)       1 (2%)       1 (2%)                                             
      Follicular Cell, Adenoma                         1 (2%)                                                                       
      Follicular Cell, Carcinoma                       1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Preputial Gland                                    (49)         (48)         (43)                                                
      Adenoma                                          2 (4%)       3 (6%)       2 (5%)                                             
      Carcinoma                                        2 (4%)       4 (8%)       4 (9%)                                             
   Prostate                                           (50)         (49)         (50)                                                
      Schwannoma Malignant                             1 (2%)                                                                       
   Seminal Vesicle                                                 (4)          (2)                                                 
   Testes                                             (49)         (50)         (50)                                                
      Seminoma Malignant, Poor                                                   1 (2%)                                             
      Interstitial Cell, Adenoma                       3 (6%)       7 (14%)     12 (24%)                                            
      Interstitial Cell, Adenoma, Multiple            43 (88%)     42 (84%)     32 (64%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Blood                                              (44)         (46)         (44)                                                
   Bone Marrow                                        (50)         (50)         (50)                                                
   Lymph Node                                         (50)         (49)         (50)                                                
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                     1 (2%)                                                          
   Spleen                                             (50)         (50)         (50)                                                
                                                             Page   8                                                               
NTP Experiment-Test: 05048-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            RHODAMINE 6G                                       Date: 09/06/94  
Route: DOSED FEED                                                                                                 Time: 23:53:03  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     UNTREATD     0.012%       0.025%                                                 
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - cont                                                                                                         
      Hemangiosarcoma                                  1 (2%)                                                                       
      Sarcoma                                          1 (2%)                                                                       
      Capsule, Sarcoma                                                           1 (2%)                                             
   Thymus                                             (47)         (47)         (47)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (49)         (46)                                                
      Fibroadenoma                                     5 (10%)      1 (2%)       4 (9%)                                             
      Fibroadenoma, Multiple                           1 (2%)                                                                       
   Skin                                               (50)         (50)         (50)                                                
      Basal Cell Adenoma                                            1 (2%)       2 (4%)                                             
      Keratoacanthoma                                  1 (2%)       2 (4%)       6 (12%)                                            
      Keratoacanthoma, Multiple                                                  2 (4%)                                             
      Squamous Cell Papilloma                          2 (4%)                    3 (6%)                                             
      Trichoepithelioma                                             1 (2%)       1 (2%)                                             
      Subcutaneous Tissue, Fibroma                     4 (8%)       6 (12%)      4 (8%)                                             
      Subcutaneous Tissue, Fibrosarcoma                             1 (2%)       1 (2%)                                             
      Subcutaneous Tissue, Liposarcoma                 1 (2%)                                                                       
      Subcutaneous Tissue, Sarcoma                                  1 (2%)                                                          
      Subcutaneous Tissue, Schwannoma Benign                        1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)                                                
      Osteoma                                                                    1 (2%)                                             
      Osteosarcoma                                                               1 (2%)                                             
      Vertebra, Chordoma                                                         1 (2%)                                             
   Skeletal Muscle                                                 (2)                                                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)                                                
      Astrocytoma Malignant                                                      1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)                                                
      Alveolar/Bronchiolar Adenoma                     2 (4%)                    1 (2%)                                             
      Alveolar/Bronchiolar Carcinoma                                1 (2%)                                                          
      Osteosarcoma, Multiple, Metastatic, Bone                                   1 (2%)                                             
   Nose                                               (50)         (50)         (45)                                                
      Adenocarcinoma                                   1 (2%)                                                                       
                                                             Page   9                                                               
NTP Experiment-Test: 05048-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            RHODAMINE 6G                                       Date: 09/06/94  
Route: DOSED FEED                                                                                                 Time: 23:53:03  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     UNTREATD     0.012%       0.025%                                                 
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - cont                                                                                                           
      Adenocarcinoma, Moderately Well                  1 (2%)                                                                       
      Papilloma                                                     1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)                                                
      Renal Tubule, Adenoma                                                      1 (2%)                                             
      Renal Tubule, Carcinoma                                       1 (2%)                                                          
   Urinary Bladder                                    (50)         (49)         (50)                                                
      Transitional Epithelium, Adenoma                              1 (2%)                                                          
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)                                                
      Leukemia Mononuclear                            27 (54%)     21 (42%)     19 (38%)                                            
      Mesothelioma Malignant                           1 (2%)       2 (4%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  10                                                               
NTP Experiment-Test: 05048-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            RHODAMINE 6G                                       Date: 09/06/94  
Route: DOSED FEED                                                                                                 Time: 23:53:03  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     UNTREATD     0.012%       0.025%                                                 
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            50          50          49                                                   
     Total Primary Neoplasms                          156         157         159                                                   
                                                                                                                                    
   Total Animals with Benign Neoplasms                 49          50          48                                                   
     Total Benign Neoplasms                           104         116         118                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms              39          33          30                                                   
     Total Malignant Neoplasms                         52          41          40                                                   
                                                                                                                                    
   Total Animals with Metastatic Neoplasms                          1           1                                                   
     Total Metastatic Neoplasm                                      1           1                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                          1                                                   
     Total Uncertain Neoplasms                                                  1                                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  11                                                               
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