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TR 364 Rat Pathology Tables

NTP Experiment-Test: 05048-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            RHODAMINE 6G                                       Date: 05/01/97
Route: DOSED FEED                                                                                                 Time: 14:20:05




       Facility:  Southern Research Institute

       Chemical CAS #:  989-38-8

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All






































                                                              Page   1

NTP Experiment-Test: 05048-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            RHODAMINE 6G                                       Date: 05/01/97  
Route: DOSED FEED                                                                                                 Time: 14:20:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7| 6| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 0| 2| 3| 3| 4| 2| 2| 4| 4| 4| 3| 6| 4| 4| 4| 0| 7| 2| 3| 3|             
                                           | 1| 6| 6| 6| 6| 5| 9| 6| 6| 0| 6| 5| 0| 0| 0| 3| 5| 0| 0| 0| 2| 5| 4| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    UNTREATD                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cecum, Parasite Metazoan             |                                                                   2      |             
      Colon, Parasite Metazoan             |    2                                                                     |             
      Rectum, Parasite Metazoan            |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis, Focal                   | 2                                                                        |             
      Basophilic Focus                     |                      X  X                 X     X                    X   |             
      Basophilic Focus, Multiple           |    X  X  X  X     X        X        X  X           X  X  X               |             
      Clear Cell Focus                     |                               X                                      X   |             
      Developmental Malformation           |                               2              2                           |             
      Granuloma                            |                                                          1               |             
      Granuloma, Multifocal                |       1     1        1     1        1     1     1     1                  |             
      Hematopoietic Cell Proliferation,    |                                                                          |             
           Multifocal                      |                                                 1                        |             
      Necrosis, Focal                      |                                                                          |             
      Necrosis, Multifocal                 |                                           1                              |             
      Vacuolization Cytoplasmic, Diffuse   |                                                 2                    1  3|             
      Biliary Tract, Hyperplasia           |       1           2        1     2     2           1  1  1     3     1   |             
      Centrilobular, Necrosis              |                   1           2  1                             1         |             
      Hepatocyte, Hypertrophy              |                   1              2                             1         |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                           +                             +|             
      Inflammation, Chronic, Focal         |                                                                         2|             
      Fat, Necrosis, Focal                 |                                           2                              |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |    3                                                     2               |             
      Inflammation, Focal, Subacute        |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Artery, Inflammation, Subacute       |                                                                          |             
      Forestomach, Hyperkeratosis          |       1                                                                  |             
      Forestomach, Hyperplasia             |       2                                                                  |             
      Forestomach, Inflammation, Subacute  |                                           3                             4|             
      Forestomach, Perforation             |                                           X                             X|             
      Forestomach, Ulcer                   |                                                                      3   |             
      Glandular, Inflammation, Subacute    |                                           3                              |             
      Glandular, Mineralization            |                                  2                                       |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis, Multifocal                 |    1              1                             1  2                 2   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05048-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            RHODAMINE 6G                                       Date: 05/01/97  
Route: DOSED FEED                                                                                                 Time: 14:20:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7| 6| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 0| 2| 3| 3| 4| 2| 2| 4| 4| 4| 3| 6| 4| 4| 4| 0| 7| 2| 3| 3|             
                                           | 1| 6| 6| 6| 6| 5| 9| 6| 6| 0| 6| 5| 0| 0| 0| 3| 5| 0| 0| 0| 2| 5| 4| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    UNTREATD                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cortex, Angiectasis, Focal           |                                                                          |             
      Cortex, Angiectasis, Multifocal      |                                                                          |             
      Cortex, Degeneration, Fatty, Focal   | 2                                                  2                     |             
      Cortex, Degeneration, Fatty,         |                                                                          |             
          Multifocal                       |                                                                          |             
      Cortex, Hyperplasia, Focal           |       2                                                                  |             
      Cortex, Hypertrophy, Focal           |                                                                          |             
      Medulla, Hyperplasia, Focal          | 1                                2                             2         |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                  1                                       |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage, Focal                    |                               4                                          |             
      Pars Distalis, Angiectasis           | 2     3  2     3  2  3           2     2  2     3  3  2  2     2  3     3|             
      Pars Distalis, Cyst                  |    X        X           X                                            X   |             
      Pars Distalis, Hyperplasia, Focal    |                                              2        2        2     2   |             
      Pars Distalis, Pigmentation,         |                                                                          |             
          Hemosiderin                      | 1     2  2     2     3           2     2  1     1     1  1     2  1      |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia, Focal           |                                        3                       2         |             
      C-Cell, Hyperplasia, Multifocal      |                         2                                                |             
      Follicle, Cyst                       |                                                       X                  |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  M  +  +  M  +  +  +  +  +  M  +  M  +  M  +  +  +  +  +  +  M  +  +|             
      Cyst                                 |                      X  X                          X                     |             
      Inflammation, Acute, Suppurative     |                         2                                                |             
      Inflammation, Focal, Subacute        |                      2                                                   |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage, Focal                    |                                                                          |             
      Inflammation, Acute, Suppurative     | 2                                            2                           |             
      Necrosis                             | 3                                            2                           |             
      Cervix, Cyst                         |                                                                X  X      |             
      Mucosa, Cyst                         |                   X                                                      |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                                          |             
      Abscess                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05048-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            RHODAMINE 6G                                       Date: 05/01/97  
Route: DOSED FEED                                                                                                 Time: 14:20:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7| 6| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 0| 2| 3| 3| 4| 2| 2| 4| 4| 4| 3| 6| 4| 4| 4| 0| 7| 2| 3| 3|             
                                           | 1| 6| 6| 6| 6| 5| 9| 6| 6| 0| 6| 5| 0| 0| 0| 3| 5| 0| 0| 0| 2| 5| 4| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    UNTREATD                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 2                                            2                           |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mandibular, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis, Focal                      |                                                                          |             
      Hematopoietic Cell Proliferation     | 4                    1                       2  2                    4   |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                             2            |             
      Hyperplasia, Glandular               |                                                                          |             
      Duct, Cyst                           | X  X  X  X  X  X  X  X     X  X  X  X  X  X  X  X  X     X  X  X  X  X  X|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                       3                  |             
      Inflammation, Acute, Focal,          |                                                                          |             
          Suppurative                      |                                                                          |             
      Inflammation, Focal, Subacute        |                      3                                                   |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                X                          X     X                        |             
      Degeneration, Multifocal             |                                                                          |             
      Hemorrhage, Multifocal               |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                         +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body, Multiple               |                                                                          |             
      Granuloma, Multifocal                |                                                                          |             
      Metaplasia, Multifocal, Osseous      |                                                                          |             
      Pigmentation, Hemosiderin            |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                                                          |             
      Inflammation, Acute, Suppurative     |                                                                          |             
      Inflammation, Granulomatous          |                                                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Acute, Suppurative              |                            2                                             |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05048-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            RHODAMINE 6G                                       Date: 05/01/97  
Route: DOSED FEED                                                                                                 Time: 14:20:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7| 6| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 0| 2| 3| 3| 4| 2| 2| 4| 4| 4| 3| 6| 4| 4| 4| 0| 7| 2| 3| 3|             
                                           | 1| 6| 6| 6| 6| 5| 9| 6| 6| 0| 6| 5| 0| 0| 0| 3| 5| 0| 0| 0| 2| 5| 4| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    UNTREATD                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                         +|             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Cataract                             |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Retina, Degeneration                 |                                                                          |             
                                            __________________________________________________________________________|             
   Lacrimal Gland                          |                                                                          |             
      Ectopic Harderian                    |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy, Chronic                 |    3  2  2  1  1  1  4  2  1  2  4  2  2  3     1  2  1  2        1     3|             
      Cortex, Cyst                         |                                                                          |             
      Cortex, Inflammation, Acute,         |                                                                          |             
          Multifocal, Suppurative          |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05048-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            RHODAMINE 6G                                       Date: 05/01/97  
Route: DOSED FEED                                                                                                 Time: 14:20:05  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 6| 6| 6| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 0| 2| 4| 4| 4| 4| 6| 9| 3| 4| 6| 6| 4| 4| 4| 5| 9| 0| 4| 4| 0| 3| 4| 4| 4|            |
                                           | 0| 6| 0| 0| 0| 6| 9| 5| 4| 0| 1| 7| 0| 0| 0| 3| 5| 0| 0| 0| 7| 4| 0| 0| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      A     |
    UNTREATD                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cecum, Parasite Metazoan             |                                                             2            |      2  2.0|
      Colon, Parasite Metazoan             |                                                    2                     |      2  2.0|
      Rectum, Parasite Metazoan            |             1                                                            |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis, Focal                   |                                                                          |      1  2.0|
      Basophilic Focus                     |          X  X                                   X  X     X              X|     11     |
      Basophilic Focus, Multiple           |       X           X     X     X     X  X              X                  |     18     |
      Clear Cell Focus                     |                                                                          |      2     |
      Developmental Malformation           |       2  1                                                               |      4  1.8|
      Granuloma                            |                                                                          |      1  1.0|
      Granuloma, Multifocal                | 2     1     1     1  1                 1  1              1        1      |     17  1.1|
      Hematopoietic Cell Proliferation,    |                                                                          |            |
           Multifocal                      |                                                                          |      1  1.0|
      Necrosis, Focal                      |                      1                                                   |      1  1.0|
      Necrosis, Multifocal                 |    1                                                                     |      2  1.0|
      Vacuolization Cytoplasmic, Diffuse   |                1     2                          2                        |      6  1.8|
      Biliary Tract, Hyperplasia           |       1        1                 2           1                           |     14  1.4|
      Centrilobular, Necrosis              |    1           1                 1                                       |      7  1.1|
      Hepatocyte, Hypertrophy              |    1                             1                                       |      5  1.2|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   2        |
      Inflammation, Chronic, Focal         |                                                                          |      1  2.0|
      Fat, Necrosis, Focal                 |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +|  48        |
      Atrophy                              | 4                             2        1  2                    1         |      7  2.1|
      Inflammation, Focal, Subacute        |                                                          2               |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Artery, Inflammation, Subacute       |                                        2                                 |      1  2.0|
      Forestomach, Hyperkeratosis          |                1                                1                        |      3  1.0|
      Forestomach, Hyperplasia             |                2                                2                        |      3  2.0|
      Forestomach, Inflammation, Subacute  |                2                                3                        |      4  3.0|
      Forestomach, Perforation             |                                                                          |      2     |
      Forestomach, Ulcer                   |                                                 4                        |      2  3.5|
      Glandular, Inflammation, Subacute    |                2                                                         |      2  2.5|
      Glandular, Mineralization            |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   6                                                               
NTP Experiment-Test: 05048-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            RHODAMINE 6G                                       Date: 05/01/97  
Route: DOSED FEED                                                                                                 Time: 14:20:05  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 6| 6| 6| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 0| 2| 4| 4| 4| 4| 6| 9| 3| 4| 6| 6| 4| 4| 4| 5| 9| 0| 4| 4| 0| 3| 4| 4| 4|            |
                                           | 0| 6| 0| 0| 0| 6| 9| 5| 4| 0| 1| 7| 0| 0| 0| 3| 5| 0| 0| 0| 7| 4| 0| 0| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      A     |
    UNTREATD                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis, Multifocal                 |       2  1                 2              2     1  1  2  1     1  1  2   |     16  1.4|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cortex, Angiectasis, Focal           |             3                                                            |      1  3.0|
      Cortex, Angiectasis, Multifocal      |                               2                                          |      1  2.0|
      Cortex, Degeneration, Fatty, Focal   |             2                       2           2                        |      5  2.0|
      Cortex, Degeneration, Fatty,         |                                                                          |            |
          Multifocal                       |                                        2                             2   |      2  2.0|
      Cortex, Hyperplasia, Focal           |                                                                          |      1  2.0|
      Cortex, Hypertrophy, Focal           |                                  2                                       |      1  2.0|
      Medulla, Hyperplasia, Focal          |    2                                                                     |      4  1.8|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  M  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Hyperplasia                          |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|  49        |
      Hemorrhage, Focal                    |                                                                          |      1  4.0|
      Pars Distalis, Angiectasis           | 3  4     3  2     2  3  2  1     1  2     2     3  2  3  3        1  3  3|     34  2.4|
      Pars Distalis, Cyst                  |    X                       X     X  X  X     X           X               |     11     |
      Pars Distalis, Hyperplasia, Focal    |                            2     2     2                                 |      7  2.0|
      Pars Distalis, Pigmentation,         |                                                                          |            |
          Hemosiderin                      |    2     1           1  2           1     1     2  1  1  1           1  2|     25  1.5|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      C-Cell, Hyperplasia, Focal           |                                                                         2|      3  2.3|
      C-Cell, Hyperplasia, Multifocal      |                                                                          |      1  2.0|
      Follicle, Cyst                       |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  42        |
      Cyst                                 |                                  X  X                                    |      5     |
      Inflammation, Acute, Suppurative     |                                                                          |      1  2.0|
      Inflammation, Focal, Subacute        |                                           2              2               |      3  2.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                   X        X                                             |      2     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   7                                                               
NTP Experiment-Test: 05048-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            RHODAMINE 6G                                       Date: 05/01/97  
Route: DOSED FEED                                                                                                 Time: 14:20:05  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 6| 6| 6| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 0| 2| 4| 4| 4| 4| 6| 9| 3| 4| 6| 6| 4| 4| 4| 5| 9| 0| 4| 4| 0| 3| 4| 4| 4|            |
                                           | 0| 6| 0| 0| 0| 6| 9| 5| 4| 0| 1| 7| 0| 0| 0| 3| 5| 0| 0| 0| 7| 4| 0| 0| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      A     |
    UNTREATD                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hemorrhage, Focal                    |    2                                                                     |      1  2.0|
      Inflammation, Acute, Suppurative     |                                                                          |      2  2.0|
      Necrosis                             |                                                                          |      2  2.5|
      Cervix, Cyst                         |                                                                          |      2     |
      Mucosa, Cyst                         |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Vagina                                  |                                                 +                        |   1        |
      Abscess                              |                                                 3                        |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   | +  +  +  +  +        +     +  +  +  +  +  +     +  +  +  +     +  +  +  +|  43        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |    1                                                                     |      3  1.7|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mandibular, Hyperplasia              |                                                                      2   |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  49        |
      Fibrosis, Focal                      |                                  2                                       |      1  2.0|
      Hematopoietic Cell Proliferation     |    3                          3                                          |      7  2.7|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  M  M  M  +  M  +  +  +|  43        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                                                          |      1  2.0|
      Hyperplasia, Glandular               |                                  3                                       |      1  3.0|
      Duct, Cyst                           | X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X     X  X  X|     47     |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                                          |      1  3.0|
      Inflammation, Acute, Focal,          |                                                                          |            |
          Suppurative                      |                                                    2                     |      1  2.0|
      Inflammation, Focal, Subacute        |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                +                                                         |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression                          | X                                                                        |      4     |
      Degeneration, Multifocal             |                                              2                       2   |      2  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   8                                                               
NTP Experiment-Test: 05048-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            RHODAMINE 6G                                       Date: 05/01/97  
Route: DOSED FEED                                                                                                 Time: 14:20:05  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 6| 6| 6| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 0| 2| 4| 4| 4| 4| 6| 9| 3| 4| 6| 6| 4| 4| 4| 5| 9| 0| 4| 4| 0| 3| 4| 4| 4|            |
                                           | 0| 6| 0| 0| 0| 6| 9| 5| 4| 0| 1| 7| 0| 0| 0| 3| 5| 0| 0| 0| 7| 4| 0| 0| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      A     |
    UNTREATD                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Hemorrhage, Multifocal               |                                                             4            |      1  4.0|
                                            __________________________________________________________________________|____________|
   Spinal Cord                             | +                                                                        |   2        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Foreign Body, Multiple               |                                                                      2   |      1  2.0|
      Granuloma, Multifocal                |                                                                      3   |      1  3.0|
      Metaplasia, Multifocal, Osseous      |                                                                      1   |      1  1.0|
      Pigmentation, Hemosiderin            |                         1                                                |      1  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Foreign Body                         |                                                                      3   |      1  3.0|
      Inflammation, Acute, Suppurative     |                   1                                                  2   |      2  1.5|
      Inflammation, Granulomatous          |                                                                      3   |      1  3.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Acute, Suppurative              |                      1                 2                                 |      3  1.7|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                        +  +              +               |   4        |
                                            __________________________________________________________________________|____________|
   Eye                                     |                +                       +                                 |   2        |
      Cataract                             |                3                                                         |      1  3.0|
      Hemorrhage                           |                2                                                         |      1  2.0|
      Retina, Degeneration                 |                3                       1                                 |      2  2.0|
                                            __________________________________________________________________________|____________|
   Lacrimal Gland                          |          +                                                               |   1        |
      Ectopic Harderian                    |          3                                                               |      1  3.0|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          | +                                                                        |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Nephropathy, Chronic                 | 1  3  1  3  1        2  2  2        1  3  2  2  2     2  2     2  1  3  2|     39  2.0|
      Cortex, Cyst                         |                                  X                                       |      1     |
      Cortex, Inflammation, Acute,         |                                                                          |            |
          Multifocal, Suppurative          |                2                                                         |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   9                                                               
NTP Experiment-Test: 05048-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            RHODAMINE 6G                                       Date: 05/01/97  
Route: DOSED FEED                                                                                                 Time: 14:20:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 4| 5| 5| 7| 7|             
                             DAY ON TEST   | 2| 9| 3| 3| 3| 3| 3| 3| 3| 3| 6| 2| 3| 3| 3| 2| 2| 3| 3| 3| 0| 3| 7| 3| 3|             
                                           | 9| 4| 4| 4| 4| 1| 4| 4| 4| 4| 2| 7| 4| 4| 4| 0| 3| 4| 4| 4| 5| 1| 5| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.025%                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  M  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis, Focal                   |                                                                          |             
      Basophilic Focus                     |                X                          X     X              X         |             
      Basophilic Focus, Multiple           |       X  X        X        X  X     X  X              X  X           X  X|             
      Congestion, Diffuse                  |                                                                          |             
      Developmental Malformation           | 2                                   2        2                           |             
      Granuloma                            |                         2                                                |             
      Granuloma, Multifocal                |                   1           1     1        2        1  1           1   |             
      Hematopoietic Cell Proliferation,    |                                                                          |             
           Multifocal                      |                                              3  1                        |             
      Hemorrhage, Multifocal               |                                           2                              |             
      Hepatodiaphragmatic Nodule           |                         X                                                |             
      Mixed Cell Focus                     |                                              4                           |             
      Necrosis, Focal                      |                                                                          |             
      Necrosis, Multifocal                 |                2                                                         |             
      Pigmentation, Hemosiderin, Multifocal|                                           1                              |             
      Thrombosis, Multiple                 |                                                             X            |             
      Vacuolization Cytoplasmic, Diffuse   | 4                                2                          2     3      |             
      Vacuolization Cytoplasmic, Focal     |             3                                                            |             
      Biliary Tract, Hyperplasia           |                                  2        1  2           1  1     2     2|             
      Centrilobular, Necrosis              |                                  1                          1           1|             
      Hepatocyte, Hypertrophy              |                                  2                                       |             
                                            __________________________________________________________________________|             
   Mesentery                               |             +                                               +            |             
      Fat, Necrosis, Focal                 |             2                                               3            |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |       2  1              2  1           2              1                  |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Multifocal, Subacute   | 2                                                                        |             
      Duct, Cyst                           | X                                                                        |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Forestomach, Edema                   | 3                                2                                4      |             
      Forestomach, Hyperkeratosis          |                                                                   2      |             
      Forestomach, Hyperplasia             |                                                             2     2      |             
      Forestomach, Ulcer                   | 2  2                    3        3                                       |             
      Forestomach, Ulcer, Multiple         |                                                                   4      |             
      Glandular, Erosion                   | 2                                                                        |             
      Glandular, Ulcer                     |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |          +                                                               |             
      Inflammation, Acute, Suppurative     |          2                                                               |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  10                                                               
NTP Experiment-Test: 05048-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            RHODAMINE 6G                                       Date: 05/01/97  
Route: DOSED FEED                                                                                                 Time: 14:20:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 4| 5| 5| 7| 7|             
                             DAY ON TEST   | 2| 9| 3| 3| 3| 3| 3| 3| 3| 3| 6| 2| 3| 3| 3| 2| 2| 3| 3| 3| 0| 3| 7| 3| 3|             
                                           | 9| 4| 4| 4| 4| 1| 4| 4| 4| 4| 2| 7| 4| 4| 4| 0| 3| 4| 4| 4| 5| 1| 5| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.025%                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis, Multifocal                 |             2  2  1  1  2     1           1           1  1               |             
      Atrium, Mineralization, Focal        |                                                                          |             
      Atrium, Pigmentation, Hemosiderin    |                                                                          |             
      Atrium, Thrombosis                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cortex, Angiectasis, Multifocal      |                                                                          |             
      Cortex, Congestion, Diffuse          |                                                                          |             
      Cortex, Degeneration, Fatty, Focal   |          2     2        2     1                                          |             
      Cortex, Degeneration, Fatty,         |                                                                          |             
          Multifocal                       |                      2                                2  3               |             
      Cortex, Hyperplasia, Focal           |                                           1                              |             
      Medulla, Hyperplasia, Focal          |                   3           1              1                           |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |    2     3  3  3  2  2  3  3     3        3  3  3  2     2  2        3   |             
      Pars Distalis, Cyst                  |                X              X        X                       X        X|             
      Pars Distalis, Hyperplasia, Focal    |                               1        2           2     2               |             
      Pars Distalis, Pigmentation,         |                                                                          |             
          Hemosiderin                      |    2     2     1     1           1                 1                 1   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia, Focal           |                                                    3                     |             
      C-Cell, Hyperplasia, Multifocal      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | M  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  M  +  +  M  M  +  +  +|             
      Cyst                                 |                                                 X                    X   |             
      Inflammation, Acute, Suppurative     |                                                                      3   |             
      Inflammation, Focal, Subacute        |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                X     X                                                   |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage, Focal                    |                                                                         3|             
      Hydrometra                           |                                                    2                     |             
      Cervix, Abscess                      | 4           4                       2                                    |             
      Cervix, Cyst                         |                      X                                                   |             
      Endometrium, Hyperplasia, Cystic     |                2                                                         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  11                                                               
NTP Experiment-Test: 05048-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            RHODAMINE 6G                                       Date: 05/01/97  
Route: DOSED FEED                                                                                                 Time: 14:20:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 4| 5| 5| 7| 7|             
                             DAY ON TEST   | 2| 9| 3| 3| 3| 3| 3| 3| 3| 3| 6| 2| 3| 3| 3| 2| 2| 3| 3| 3| 0| 3| 7| 3| 3|             
                                           | 9| 4| 4| 4| 4| 1| 4| 4| 4| 4| 2| 7| 4| 4| 4| 0| 3| 4| 4| 4| 5| 1| 5| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.025%                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Mucosa, Cyst                         |                X                                                         |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    2                                                                     |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inguinal, Hyperplasia                |                                                                          |             
      Mandibular, Ectasia                  |                                           2                              |             
      Mesenteric, Congestion               |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hematopoietic Cell Proliferation     |    2     1                                                               |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |          X                                                               |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Glandular               |                         3                                                |             
      Duct, Cyst                           | X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X     X  X  X|             
      Duct, Cyst, Multiple                 |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                                                          |             
      Inflammation, Acute, Focal,          |                                                                          |             
          Suppurative                      |          1                                                               |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                         X                                                |             
      Necrosis, Multifocal                 |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Macrophage              |                                                                          |             
      Pigmentation, Hemosiderin            |                                                                          |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Fungus                               |                                                          2               |             
      Inflammation, Acute, Suppurative     |                                           1              1               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  12                                                               
NTP Experiment-Test: 05048-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            RHODAMINE 6G                                       Date: 05/01/97  
Route: DOSED FEED                                                                                                 Time: 14:20:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 4| 5| 5| 7| 7|             
                             DAY ON TEST   | 2| 9| 3| 3| 3| 3| 3| 3| 3| 3| 6| 2| 3| 3| 3| 2| 2| 3| 3| 3| 0| 3| 7| 3| 3|             
                                           | 9| 4| 4| 4| 4| 1| 4| 4| 4| 4| 2| 7| 4| 4| 4| 0| 3| 4| 4| 4| 5| 1| 5| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.025%                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Nasolacrimal Duct, Foreign Body      |                                                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Acute, Suppurative              |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     | +     +     +     +              +        +                             +|             
      Inflammation, Acute, Suppurative     |                                                                         2|             
                                            __________________________________________________________________________|             
   Eye                                     |       +     +                 +  +                                      +|             
      Cataract                             |                               4                                         2|             
      Cornea, Inflammation, Chronic        |             3                    3                                       |             
      Retina, Degeneration                 |       2                       4  2                                      2|             
                                            __________________________________________________________________________|             
   Lacrimal Gland                          |                                                                          |             
      Ectopic Harderian                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy, Chronic                 | 4     1  3  1     2  4  2  1  1  3     2  1  3        1  1     2     2  1|             
      Medulla, Mineralization, Focal       |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  13                                                               
NTP Experiment-Test: 05048-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            RHODAMINE 6G                                       Date: 05/01/97  
Route: DOSED FEED                                                                                                 Time: 14:20:05  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 3| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 5| 7| 7| 7|            |
                             DAY ON TEST   | 9| 2| 3| 3| 3| 4| 6| 3| 3| 3| 6| 2| 3| 3| 3| 3| 2| 3| 3| 3| 1| 5| 3| 3| 3|            |
                                           | 7| 9| 4| 4| 4| 3| 0| 4| 4| 4| 1| 8| 4| 4| 4| 5| 9| 5| 5| 5| 5| 3| 4| 5| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|      A     |
    0.025%                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis, Focal                   |                            2                                             |      1  2.0|
      Basophilic Focus                     |                                                                   X      |      5     |
      Basophilic Focus, Multiple           | X     X  X  X  X     X  X  X     X  X  X     X  X  X     X           X  X|     28     |
      Congestion, Diffuse                  |                                  1                                       |      1  1.0|
      Developmental Malformation           |                                                                          |      3  2.0|
      Granuloma                            |                                                                          |      1  2.0|
      Granuloma, Multifocal                | 1     1  1           1     1        1           1  1                 1   |     16  1.1|
      Hematopoietic Cell Proliferation,    |                                                                          |            |
           Multifocal                      |                                                                          |      2  2.0|
      Hemorrhage, Multifocal               |                                                                          |      1  2.0|
      Hepatodiaphragmatic Nodule           |                                                    X                 X   |      3     |
      Mixed Cell Focus                     |                                                                          |      1  4.0|
      Necrosis, Focal                      |                         1                                                |      1  1.0|
      Necrosis, Multifocal                 |                                                                         1|      2  1.5|
      Pigmentation, Hemosiderin, Multifocal|                                                                          |      1  1.0|
      Thrombosis, Multiple                 |                                                                          |      1     |
      Vacuolization Cytoplasmic, Diffuse   |                               3  1                             2         |      7  2.4|
      Vacuolization Cytoplasmic, Focal     |                                                                          |      1  3.0|
      Biliary Tract, Hyperplasia           |    3              1     1  1  1           2                              |     13  1.5|
      Centrilobular, Necrosis              |                   1     1     1  1                                       |      7  1.0|
      Hepatocyte, Hypertrophy              |                   1              2                                2      |      4  1.8|
                                            __________________________________________________________________________|____________|
   Mesentery                               |             +           +                          +  +        +     +  +|   9        |
      Fat, Necrosis, Focal                 |             2           3                          3  X        3     3  2|      9  2.6|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                         2        1                                       |      8  1.5|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|  49        |
      Inflammation, Multifocal, Subacute   |                                                                          |      1  2.0|
      Duct, Cyst                           |                                  X                                       |      2     |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Forestomach, Edema                   |                                                                2         |      4  2.8|
      Forestomach, Hyperkeratosis          |                                                                2         |      2  2.0|
      Forestomach, Hyperplasia             |                                                                2         |      3  2.0|
      Forestomach, Ulcer                   |                                                                          |      4  2.5|
      Forestomach, Ulcer, Multiple         |                                                                          |      1  4.0|
      Glandular, Erosion                   |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  14                                                               
NTP Experiment-Test: 05048-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            RHODAMINE 6G                                       Date: 05/01/97  
Route: DOSED FEED                                                                                                 Time: 14:20:05  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 3| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 5| 7| 7| 7|            |
                             DAY ON TEST   | 9| 2| 3| 3| 3| 4| 6| 3| 3| 3| 6| 2| 3| 3| 3| 3| 2| 3| 3| 3| 1| 5| 3| 3| 3|            |
                                           | 7| 9| 4| 4| 4| 3| 0| 4| 4| 4| 1| 8| 4| 4| 4| 5| 9| 5| 5| 5| 5| 3| 4| 5| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|      A     |
    0.025%                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Glandular, Ulcer                     |                                                                   2      |      1  2.0|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                 +                        |   1        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
      Inflammation, Acute, Suppurative     |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis, Multifocal                 | 2     1  2     2  1  1     1     1     2              1  2           1  2|     22  1.4|
      Atrium, Mineralization, Focal        |                                  2                                       |      1  2.0|
      Atrium, Pigmentation, Hemosiderin    |                                  1                                       |      1  1.0|
      Atrium, Thrombosis                   |                                  2                                       |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cortex, Angiectasis, Multifocal      |                                                       3                  |      1  3.0|
      Cortex, Congestion, Diffuse          |                                  2                                       |      1  2.0|
      Cortex, Degeneration, Fatty, Focal   |                   2                             2                    2   |      7  1.9|
      Cortex, Degeneration, Fatty,         |                                                                          |            |
          Multifocal                       |    3                                                              2      |      5  2.4|
      Cortex, Hyperplasia, Focal           |                      2                                                   |      2  1.5|
      Medulla, Hyperplasia, Focal          |    1  2           1                                   1  1               |      8  1.4|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|  46        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pars Distalis, Angiectasis           | 3        3  3  2     2  2  2     2  1  3        1        1     3        2|     30  2.4|
      Pars Distalis, Cyst                  |    X                                                  X           X      |      8     |
      Pars Distalis, Hyperplasia, Focal    |    1                                1     2     2        2               |      9  1.7|
      Pars Distalis, Pigmentation,         |                                                                          |            |
          Hemosiderin                      |          1  2           1  1     1  1  1        1                        |     15  1.2|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      C-Cell, Hyperplasia, Focal           |    2                          2                       1           3      |      5  2.2|
      C-Cell, Hyperplasia, Multifocal      |                                                 2                        |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  M  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  M  +|  39        |
      Cyst                                 |                         X                 X                              |      4     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  15                                                               
NTP Experiment-Test: 05048-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            RHODAMINE 6G                                       Date: 05/01/97  
Route: DOSED FEED                                                                                                 Time: 14:20:05  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 3| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 5| 7| 7| 7|            |
                             DAY ON TEST   | 9| 2| 3| 3| 3| 4| 6| 3| 3| 3| 6| 2| 3| 3| 3| 3| 2| 3| 3| 3| 1| 5| 3| 3| 3|            |
                                           | 7| 9| 4| 4| 4| 3| 0| 4| 4| 4| 1| 8| 4| 4| 4| 5| 9| 5| 5| 5| 5| 3| 4| 5| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|      A     |
    0.025%                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Acute, Suppurative     |                                           3  2                           |      3  2.7|
      Inflammation, Focal, Subacute        |                         2                                                |      1  2.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |    X           X                                   X              X      |      6     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage, Focal                    |                                                                          |      1  3.0|
      Hydrometra                           |                                                                          |      1  2.0|
      Cervix, Abscess                      |                                                 3  3                     |      5  3.2|
      Cervix, Cyst                         |                                                 X  X                     |      3     |
      Endometrium, Hyperplasia, Cystic     |                                                                          |      1  2.0|
      Mucosa, Cyst                         |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                              4                           |      2  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inguinal, Hyperplasia                |                                              2                           |      1  2.0|
      Mandibular, Ectasia                  |                                                                          |      1  2.0|
      Mesenteric, Congestion               |                                  2                                       |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |       2                                                                  |      1  2.0|
      Hematopoietic Cell Proliferation     |       1                                      4                          3|      5  2.2|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  49        |
      Cyst                                 |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Glandular               |                                                                          |      1  3.0|
      Duct, Cyst                           | X  X  X  X  X        X           X     X  X  X  X  X  X  X     X  X  X  X|     42     |
      Duct, Cyst, Multiple                 |                            X                                             |      1     |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst Epithelial Inclusion            |                            X                                             |      1     |
      Inflammation, Acute, Focal,          |                                                                          |            |
          Suppurative                      |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  16                                                               
NTP Experiment-Test: 05048-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            RHODAMINE 6G                                       Date: 05/01/97  
Route: DOSED FEED                                                                                                 Time: 14:20:05  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 3| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 5| 7| 7| 7|            |
                             DAY ON TEST   | 9| 2| 3| 3| 3| 4| 6| 3| 3| 3| 6| 2| 3| 3| 3| 3| 2| 3| 3| 3| 1| 5| 3| 3| 3|            |
                                           | 7| 9| 4| 4| 4| 3| 0| 4| 4| 4| 1| 8| 4| 4| 4| 5| 9| 5| 5| 5| 5| 3| 4| 5| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|      A     |
    0.025%                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression                          |                                  X                             X         |      3     |
      Necrosis, Multifocal                 |    1                                                                     |      1  1.0|
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                   +                          +              +            |   3        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Macrophage              |                                  2                                       |      1  2.0|
      Pigmentation, Hemosiderin            |                                  1                                       |      1  1.0|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |                      2                                                   |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +|  47        |
      Fungus                               |                                                                          |      1  2.0|
      Inflammation, Acute, Suppurative     |                                                                          |      2  1.0|
      Nasolacrimal Duct, Foreign Body      |                                                 1                        |      1  1.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Acute, Suppurative              |                                                 1                 2      |      2  1.5|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                   +     +  +                    +           +            |  12        |
      Inflammation, Acute, Suppurative     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                             +            |   6        |
      Cataract                             |                                                             2            |      3  2.7|
      Cornea, Inflammation, Chronic        |                                                                          |      2  3.0|
      Retina, Degeneration                 |                                                             3            |      5  2.6|
                                            __________________________________________________________________________|____________|
   Lacrimal Gland                          |                                                                   +      |   1        |
      Ectopic Harderian                    |                                                                   2      |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Nephropathy, Chronic                 | 2  1     3  1     2     1        2  1  2  1     3     1  1  1  2  2  2  3|     36  1.8|
      Medulla, Mineralization, Focal       |                   2                                                      |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  17                                                               
NTP Experiment-Test: 05048-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            RHODAMINE 6G                                       Date: 05/01/97  
Route: DOSED FEED                                                                                                 Time: 14:20:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 7| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 7| 3| 3| 3| 6| 7| 0| 2| 3| 9| 3| 3| 3| 3|             
                                           | 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 9| 5| 5| 5| 5| 8| 5| 0| 5| 5| 7| 5| 6| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    0.012%                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Colon, Parasite Metazoan             |                                                                          |             
      Rectum, Parasite Metazoan            |                                                       2                  |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis, Focal                   |                                                    2                     |             
      Basophilic Focus                     |                            X                          X              X  X|             
      Basophilic Focus, Multiple           |       X  X  X  X  X  X  X           X  X  X     X              X  X      |             
      Developmental Malformation           |       2              2     2                                             |             
      Granuloma                            |                            1                                             |             
      Granuloma, Multifocal                |    1  1     2           2                             3        2  1  2   |             
      Hepatodiaphragmatic Nodule           |                                                                      X   |             
      Necrosis, Focal                      |                                                                          |             
      Vacuolization Cytoplasmic, Diffuse   |                                  3           1              2            |             
      Vacuolization Cytoplasmic, Focal     |                         2                                                |             
      Biliary Tract, Hyperplasia           | 2           2     1              2  1     1  1           1  1     1  1  1|             
      Centrilobular, Necrosis              |                                           1  1                           |             
      Hepatocyte, Hypertrophy              | 1                                            1                           |             
                                            __________________________________________________________________________|             
   Mesentery                               |                      +                                                   |             
      Fat, Necrosis, Focal                 |                      3                                                   |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |       2        1                          2              1  2            |             
      Artery, Inflammation, Subacute       |                                     3                                    |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Duct, Cyst                           | X                                                                        |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Forestomach, Edema                   |                                                                          |             
      Forestomach, Hyperkeratosis          |                                                             2            |             
      Forestomach, Hyperplasia             |                                                             2            |             
      Forestomach, Inflammation, Subacute  |                                                             2            |             
      Forestomach, Ulcer                   |                                     3                       2            |             
      Forestomach, Ulcer, Multiple         |                                                                          |             
      Glandular, Edema                     |                                                                          |             
      Glandular, Erosion                   |                                                                          |             
      Glandular, Inflammation, Subacute    |                                                                          |             
      Glandular, Ulcer                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis, Multifocal                 |       1  1  2  2  1     2           2  1  1     1     1           1     1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  18                                                               
NTP Experiment-Test: 05048-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            RHODAMINE 6G                                       Date: 05/01/97  
Route: DOSED FEED                                                                                                 Time: 14:20:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 7| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 7| 3| 3| 3| 6| 7| 0| 2| 3| 9| 3| 3| 3| 3|             
                                           | 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 9| 5| 5| 5| 5| 8| 5| 0| 5| 5| 7| 5| 6| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    0.012%                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Accessory Adrenal Cortical Nodule    |                                                                          |             
      Cortex, Angiectasis, Focal           |                                     2                                    |             
      Cortex, Congestion, Diffuse          | 2                                                                        |             
      Cortex, Degeneration, Fatty, Focal   |    1        2           2                    1        1                  |             
      Cortex, Degeneration, Fatty,         |                                                                          |             
          Multifocal                       |                   2                 2              2                     |             
      Cortex, Hyperplasia, Focal           |                            2                                             |             
      Cortex, Necrosis, Focal              |                                                                          |             
      Medulla, Hyperplasia, Focal          |             2                       2                                    |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage, Focal                    |                                                                          |             
      Pars Distalis, Angiectasis           | 1  3  3                    3        3  2  3     4  4  1  4  2  3        3|             
      Pars Distalis, Cyst                  |                X  X  X  X              X     X                       X   |             
      Pars Distalis, Hyperplasia, Focal    |             1           1              3     1                    2  2   |             
      Pars Distalis, Pigmentation,         |                                                                          |             
          Hemosiderin                      | 1     1                    1        1           1     2        1        1|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia, Focal           |                                                                          |             
      C-Cell, Hyperplasia, Multifocal      |       2                                                                  |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Inflammation, Acute, Suppurative     |       2                             2                                    |             
      Inflammation, Focal, Subacute        |                                        2                                 |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                   X                 X                                    |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydrometra                           |                   2                                                      |             
      Cervix, Abscess                      |    3           3        3              3                                 |             
      Cervix, Cyst                         |    X           X        X              X                                 |             
      Cervix, Necrosis                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |    +  +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Deep Cervical, Congestion            | 2                                                                        |             
      Inguinal, Hyperplasia                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  19                                                               
NTP Experiment-Test: 05048-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            RHODAMINE 6G                                       Date: 05/01/97  
Route: DOSED FEED                                                                                                 Time: 14:20:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 7| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 7| 3| 3| 3| 6| 7| 0| 2| 3| 9| 3| 3| 3| 3|             
                                           | 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 9| 5| 5| 5| 5| 8| 5| 0| 5| 5| 7| 5| 6| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    0.012%                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Mandibular, Ectasia                  |                                                                   1      |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |       1        1                                            1            |             
      Hyperplasia, Focal, Lymphoid         |                                                                          |             
      Necrosis, Focal                      |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Glandular               |                                                                      2  3|             
      Duct, Cyst                           | X     X     X  X  X     X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                     2              2                     |             
      Hyperkeratosis, Focal                |                                                                          |             
      Hyperplasia, Focal                   |                                                                          |             
      Inflammation, Acute, Focal,          |                                                                          |             
          Suppurative                      |                                     3                                    |             
      Inflammation, Granulomatous,         |                                                                          |             
          Multifocal                       |                                                    2                     |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cranium, Hyperostosis, Focal         |                      4                                                   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |       X                             X           X                        |             
      Degeneration, Multifocal             |             2                                         2                  |             
      Hemorrhage, Multifocal               |                                                                          |             
      Mineralization, Focal                |                      2                                                   |             
      Cerebellum, Mineralization,          |                                                                          |             
          Multifocal                       |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atelectasis, Multifocal              |                                                                          |             
      Congestion                           | 3                                                                        |             
      Hemorrhage, Multifocal               | 2                                                                        |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fungus                               |                                                             3            |             
      Inflammation, Acute, Suppurative     |                                                 1           2            |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  20                                                               
NTP Experiment-Test: 05048-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            RHODAMINE 6G                                       Date: 05/01/97  
Route: DOSED FEED                                                                                                 Time: 14:20:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 7| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 7| 3| 3| 3| 6| 7| 0| 2| 3| 9| 3| 3| 3| 3|             
                                           | 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 9| 5| 5| 5| 5| 8| 5| 0| 5| 5| 7| 5| 6| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    0.012%                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
           Acute, Suppurative              |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |             +        +  +              +  +              +  +  +         |             
                                            __________________________________________________________________________|             
   Eye                                     |    +  +  +  +  +  +  +  +  +        +  +  +  +  +  +     +     +  +  +  +|             
      Cataract                             |    2  4  3  4  3  3  4  4  4        4  3  3  3  2  4     1     4  4  3  2|             
      Retina, Degeneration                 |    3  4  3  4  3  3  3  4  4        4  3  3  3  2  3     3     4  3  3  3|             
                                            __________________________________________________________________________|             
   Lacrimal Gland                          |             +           +              +                                 |             
      Ectopic Harderian                    |             2           2              X                                 |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy, Chronic                 | 2  1  2  1  2           2  2     1  3     2  2  3  4     1     2  1  1  2|             
      Right, Hydronephrosis                |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  21                                                               
NTP Experiment-Test: 05048-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            RHODAMINE 6G                                       Date: 05/01/97  
Route: DOSED FEED                                                                                                 Time: 14:20:05  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7|            |
                             DAY ON TEST   | 0| 3| 2| 3| 3| 2| 2| 3| 3| 3| 6| 9| 3| 3| 3| 6| 2| 3| 3| 3| 7| 5| 2| 3| 3|            |
                                           | 3| 8| 8| 6| 6| 5| 9| 6| 6| 6| 0| 6| 6| 6| 6| 4| 2| 6| 6| 6| 2| 7| 8| 6| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      A     |
    0.012%                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Colon, Parasite Metazoan             |                         2  2                                             |      2  2.0|
      Rectum, Parasite Metazoan            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|  49        |
      Angiectasis, Focal                   |                                                                          |      1  2.0|
      Basophilic Focus                     |                X  X     X                          X                     |      8     |
      Basophilic Focus, Multiple           |          X  X        X     X        X     X                       X  X  X|     22     |
      Developmental Malformation           |                                              2                           |      4  2.0|
      Granuloma                            |                                                                          |      1  1.0|
      Granuloma, Multifocal                |          1  2  1  1  2           2  1     2           1           1      |     18  1.6|
      Hepatodiaphragmatic Nodule           |       X                                                                  |      2     |
      Necrosis, Focal                      |                   1                                                      |      1  1.0|
      Vacuolization Cytoplasmic, Diffuse   |       3                       3              2  1              3         |      8  2.3|
      Vacuolization Cytoplasmic, Focal     |                                                             1            |      2  1.5|
      Biliary Tract, Hyperplasia           |    3  2                 1  1           2     2  2                        |     19  1.5|
      Centrilobular, Necrosis              |    1                                   1     1  2                        |      6  1.2|
      Hepatocyte, Hypertrophy              |    2  2                                      1  1                        |      6  1.3|
                                            __________________________________________________________________________|____________|
   Mesentery                               | +                                                                        |   2        |
      Fat, Necrosis, Focal                 | 2                                                                        |      2  2.5|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Atrophy                              |       3     1        1              1                                    |      9  1.6|
      Artery, Inflammation, Subacute       |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Duct, Cyst                           |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Forestomach, Edema                   |       2                                                                  |      1  2.0|
      Forestomach, Hyperkeratosis          |       1                                            2           2  2      |      5  1.8|
      Forestomach, Hyperplasia             |       2                                            2           2  2      |      5  2.0|
      Forestomach, Inflammation, Subacute  |       2                                            2           2         |      4  2.0|
      Forestomach, Ulcer                   |       4                                                        3         |      4  3.0|
      Forestomach, Ulcer, Multiple         |                                                    3                     |      1  3.0|
      Glandular, Edema                     |       2                                                                  |      1  2.0|
      Glandular, Erosion                   |                                                                2         |      1  2.0|
      Glandular, Inflammation, Subacute    |                                                                2         |      1  2.0|
      Glandular, Ulcer                     |                                                                2         |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  22                                                               
NTP Experiment-Test: 05048-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            RHODAMINE 6G                                       Date: 05/01/97  
Route: DOSED FEED                                                                                                 Time: 14:20:05  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7|            |
                             DAY ON TEST   | 0| 3| 2| 3| 3| 2| 2| 3| 3| 3| 6| 9| 3| 3| 3| 6| 2| 3| 3| 3| 7| 5| 2| 3| 3|            |
                                           | 3| 8| 8| 6| 6| 5| 9| 6| 6| 6| 0| 6| 6| 6| 6| 4| 2| 6| 6| 6| 2| 7| 8| 6| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      A     |
    0.012%                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis, Multifocal                 |       2     1  2  1  1  1  1              2        2  2  2        2     2|     26  1.5|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accessory Adrenal Cortical Nodule    |                                  X                                       |      1     |
      Cortex, Angiectasis, Focal           |                                                                          |      1  2.0|
      Cortex, Congestion, Diffuse          |                                                                          |      1  2.0|
      Cortex, Degeneration, Fatty, Focal   |    2  2     1        3     2              2        3           2         |     13  1.8|
      Cortex, Degeneration, Fatty,         |                                                                          |            |
          Multifocal                       | 2                                                                        |      4  2.0|
      Cortex, Hyperplasia, Focal           |                                                                         2|      2  2.0|
      Cortex, Necrosis, Focal              |                                                             3            |      1  3.0|
      Medulla, Hyperplasia, Focal          |                            1           2           2  1                  |      6  1.7|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hemorrhage, Focal                    |                                              2                           |      1  2.0|
      Pars Distalis, Angiectasis           |       4  2  4  3     3  2  4  3  2        1        3  3  2  3  4        4|     30  2.9|
      Pars Distalis, Cyst                  | X     X        X  X     X     X     X  X  X        X              X      |     18     |
      Pars Distalis, Hyperplasia, Focal    |                                        2                                 |      7  1.7|
      Pars Distalis, Pigmentation,         |                                                                          |            |
          Hemosiderin                      |    2        1  1        2  1  1  1                 2  2                  |     17  1.3|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      C-Cell, Hyperplasia, Focal           |                                        2                                 |      1  2.0|
      C-Cell, Hyperplasia, Multifocal      |                                                                         1|      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  M  M  +  M  M  +  M  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +|  40        |
      Cyst                                 |                                     X                          X         |      2     |
      Inflammation, Acute, Suppurative     | 3                                   2                                    |      4  2.3|
      Inflammation, Focal, Subacute        |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cyst                                 |    X                       X                                      X      |      5     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hydrometra                           |                                                       2                  |      2  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  23                                                               
NTP Experiment-Test: 05048-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            RHODAMINE 6G                                       Date: 05/01/97  
Route: DOSED FEED                                                                                                 Time: 14:20:05  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7|            |
                             DAY ON TEST   | 0| 3| 2| 3| 3| 2| 2| 3| 3| 3| 6| 9| 3| 3| 3| 6| 2| 3| 3| 3| 7| 5| 2| 3| 3|            |
                                           | 3| 8| 8| 6| 6| 5| 9| 6| 6| 6| 0| 6| 6| 6| 6| 4| 2| 6| 6| 6| 2| 7| 8| 6| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      A     |
    0.012%                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Cervix, Abscess                      |                                                                   4      |      5  3.2|
      Cervix, Cyst                         |                                                                   X      |      5     |
      Cervix, Necrosis                     |    3                                                                     |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |       +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +        +  +  +|  42        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Deep Cervical, Congestion            |                                                                          |      1  2.0|
      Inguinal, Hyperplasia                | 2                                                                        |      1  2.0|
      Mandibular, Ectasia                  |       1                                                                  |      2  1.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hematopoietic Cell Proliferation     | 3                             2                                          |      5  1.6|
      Hyperplasia, Focal, Lymphoid         |             4                                                            |      1  4.0|
      Necrosis, Focal                      |                                              3                           |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|  46        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                                             2            |      1  2.0|
      Hyperplasia, Glandular               |                                                             3            |      3  2.7|
      Duct, Cyst                           | X  X  X  X  X  X  X  X  X  X  X  X     X     X  X  X  X  X  X  X     X  X|     44     |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Foreign Body                         |                            2                                             |      3  2.0|
      Hyperkeratosis, Focal                |             4                                                            |      1  4.0|
      Hyperplasia, Focal                   |             2                                                            |      1  2.0|
      Inflammation, Acute, Focal,          |                                                                          |            |
          Suppurative                      |                            3                                             |      2  3.0|
      Inflammation, Granulomatous,         |                                                                          |            |
          Multifocal                       |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cranium, Hyperostosis, Focal         |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression                          |                                                                3         |      4  3.0|
      Degeneration, Multifocal             |                2  2              2                    2           3      |      7  2.1|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  24                                                               
NTP Experiment-Test: 05048-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            RHODAMINE 6G                                       Date: 05/01/97  
Route: DOSED FEED                                                                                                 Time: 14:20:05  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7|            |
                             DAY ON TEST   | 0| 3| 2| 3| 3| 2| 2| 3| 3| 3| 6| 9| 3| 3| 3| 6| 2| 3| 3| 3| 7| 5| 2| 3| 3|            |
                                           | 3| 8| 8| 6| 6| 5| 9| 6| 6| 6| 0| 6| 6| 6| 6| 4| 2| 6| 6| 6| 2| 7| 8| 6| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      A     |
    0.012%                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Hemorrhage, Multifocal               |    2                                            2                        |      2  2.0|
      Mineralization, Focal                |                                                                          |      1  2.0|
      Cerebellum, Mineralization,          |                                                                          |            |
          Multifocal                       |                                                                   2      |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                   +      |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atelectasis, Multifocal              |                                        2                                 |      1  2.0|
      Congestion                           |                                                                          |      1  3.0|
      Hemorrhage, Multifocal               |                                                          2               |      2  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fungus                               |       4                                                                  |      2  3.5|
      Inflammation, Acute, Suppurative     |       2                                                                  |      3  1.7|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Acute, Suppurative              |                                     1                                    |      1  1.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                   +              +        +                              |  11        |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                        +                                 |  21        |
      Cataract                             |                                        4                                 |     21  3.2|
      Retina, Degeneration                 |                                        3                                 |     21  3.2|
                                            __________________________________________________________________________|____________|
   Lacrimal Gland                          |                                                                          |   3        |
      Ectopic Harderian                    |                                                                          |      3  2.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Nephropathy, Chronic                 | 1     3  1  1  1     1     2  3  1  1  3  2  1     3        2  4  2  2  2|     37  1.9|
      Right, Hydronephrosis                |                                                    3                     |      1  3.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  25                                                               
NTP Experiment-Test: 05048-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            RHODAMINE 6G                                       Date: 05/01/97  
Route: DOSED FEED                                                                                                 Time: 14:20:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 5| 6| 6| 6| 7| 6| 6| 7| 7| 7|             
                             DAY ON TEST   | 6| 9| 2| 3| 3| 1| 2| 9| 3| 3| 3| 3| 3| 3| 3| 7| 0| 9| 9| 3| 0| 2| 1| 3| 3|             
                                           | 8| 9| 4| 4| 6| 8| 0| 5| 4| 6| 4| 6| 6| 6| 6| 6| 3| 4| 5| 6| 0| 1| 3| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    UNTREATD                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Colon, Cyst                          |                                                                          |             
      Colon, Diverticulum                  |                                                                          |             
      Colon, Edema                         |                                                                          |             
      Colon, Parasite Metazoan             |                      2     2                             2               |             
      Rectum, Mineralization               | 2                                                                        |             
      Rectum, Parasite Metazoan            |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis, Focal                   | 2                       2           1                                    |             
      Angiectasis, Multifocal              |    2     2                                                           1   |             
      Basophilic Focus                     | X                                                                        |             
      Basophilic Focus, Multiple           |    X                                                                 X   |             
      Developmental Malformation           |                2     2                                2              2   |             
      Fibrosis, Focal                      |                                                                          |             
      Granuloma, Multifocal                |                         2                                                |             
      Hemorrhage, Focal                    |                                                                          |             
      Necrosis, Multifocal                 |                                                                          |             
      Pigmentation, Focal, Hemosiderin     |                                                                          |             
      Vacuolization Cytoplasmic, Diffuse   |       3                                                                  |             
      Vacuolization Cytoplasmic, Focal     |                                                                          |             
      Vacuolization Cytoplasmic, Multifocal|                                                                          |             
      Biliary Tract, Hyperplasia           |    1     2  3  2  2  1  2  1  4  2     3  2     2  3  2           3     2|             
      Centrilobular, Necrosis              |                               2                    1  1           1      |             
      Hepatocyte, Hypertrophy              |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                           +                              |             
      Fat, Necrosis, Focal                 |                                           2                              |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |          1           1     2                 2                          2|             
      Artery, Inflammation, Subacute       |                      3                                   2               |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Artery, Inflammation, Subacute       |                                                                          |             
      Forestomach, Foreign Body            |                                                 2                        |             
      Forestomach, Hyperkeratosis          |                                     2                                    |             
      Forestomach, Hyperplasia             |                                     2                                    |             
      Forestomach, Inflammation, Focal,    |                                                                          |             
           Granulomatous                   |                                                 2                        |             
      Forestomach, Inflammation, Subacute  |                                     2                                    |             
      Forestomach, Mineralization          | 1                                                                        |             
      Forestomach, Ulcer                   |                2                    2                                    |             
      Glandular, Mineralization            | 2                                                                        |             
      Glandular, Ulcer                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  26                                                               
NTP Experiment-Test: 05048-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            RHODAMINE 6G                                       Date: 05/01/97  
Route: DOSED FEED                                                                                                 Time: 14:20:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 5| 6| 6| 6| 7| 6| 6| 7| 7| 7|             
                             DAY ON TEST   | 6| 9| 2| 3| 3| 1| 2| 9| 3| 3| 3| 3| 3| 3| 3| 7| 0| 9| 9| 3| 0| 2| 1| 3| 3|             
                                           | 8| 9| 4| 4| 6| 8| 0| 5| 4| 6| 4| 6| 6| 6| 6| 6| 3| 4| 5| 6| 0| 1| 3| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    UNTREATD                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Glandular, Ulcer, Multiple           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +                                                                        |             
      Mineralization                       | 3                                                                        |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis, Multifocal                 | 2     2     1     2        1  2        2  2  2     2  2  2  2     2  2  2|             
      Mineralization                       | 2                                                                        |             
      Atrium, Thrombosis                   |       X                    3                                             |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cortex, Angiectasis, Focal           |                                                                   2      |             
      Cortex, Congestion                   |                                                                          |             
      Cortex, Degeneration, Fatty, Focal   |                                           1                              |             
      Cortex, Degeneration, Fatty,         |                                                                          |             
          Multifocal                       |                                  2  2                                    |             
      Cortex, Hyperplasia, Multifocal      |                                                                          |             
      Cortex, Hyperplasia, Multifocal,     |                                                                          |             
           Multifocal                      |                                                                          |             
      Medulla, Hyperplasia, Focal          |       2                          2  2                                    |             
      Medulla, Hyperplasia, Multifocal     |                            1                                             |             
      Medulla, Necrosis, Multifocal        |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 2                    1     1                                         1   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           | 2     2     4           2                    4                           |             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hemorrhage, Focal     |                                                                          |             
      Pars Distalis, Hyperplasia, Focal    | 2                                               2                        |             
      Pars Distalis, Pigmentation,         |                                                                          |             
          Hemosiderin                      | 2     1     2           2                                                |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ultimobranchial Cyst                 |                                                 X                        |             
      C-Cell, Hyperplasia, Focal           |                            2                                             |             
      C-Cell, Hyperplasia, Multifocal      |                                        2                                 |             
      Follicle, Cyst                       |                                                                          |             
      Follicle, Hyperplasia, Cystic, Focal |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  27                                                               
NTP Experiment-Test: 05048-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            RHODAMINE 6G                                       Date: 05/01/97  
Route: DOSED FEED                                                                                                 Time: 14:20:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 5| 6| 6| 6| 7| 6| 6| 7| 7| 7|             
                             DAY ON TEST   | 6| 9| 2| 3| 3| 1| 2| 9| 3| 3| 3| 3| 3| 3| 3| 7| 0| 9| 9| 3| 0| 2| 1| 3| 3|             
                                           | 8| 9| 4| 4| 6| 8| 0| 5| 4| 6| 4| 6| 6| 6| 6| 6| 3| 4| 5| 6| 0| 1| 3| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    UNTREATD                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute, Suppurative     | 3                       3     2                                          |             
      Inflammation, Subacute               |                                                                2         |             
      Duct, Cyst                           | X                                                                        |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Inflammation, Acute, Suppurative     | 1     2     3                 2           2  2                 2  2     1|             
      Inflammation, Chronic                |                   1                 2                 1                  |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                              3                           |             
      Inflammation, Acute, Suppurative     | 3                                                                        |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +|             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Iliac, Ectasia                       |                                                                          |             
      Inguinal, Hyperplasia                |                                                                          |             
      Mandibular, Ectasia                  |                                        2     3                           |             
      Mediastinal, Hyperplasia             |                                                                          |             
      Mesenteric, Angiectasis              | 2                                                                        |             
      Mesenteric, Congestion               |                                                                      2   |             
      Mesenteric, Ectasia                  |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                      3   |             
      Developmental Malformation           |                                                                          |             
      Fibrosis                             | 2     3              3                 2                             3   |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Capsule, Fibrosis, Focal             |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Duct, Cyst                           |       X     X                                X                           |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alopecia                             |                                     X                                    |             
      Cyst Epithelial Inclusion            |                                                                          |             
      Hyperkeratosis, Focal                |                                                                          |             
      Hyperplasia, Focal                   |                                                                          |             
      Inflammation, Acute, Focal,          |                                                                          |             
          Suppurative                      |       2                                                                  |             
      Inflammation, Focal, Granulomatous   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  28                                                               
NTP Experiment-Test: 05048-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            RHODAMINE 6G                                       Date: 05/01/97  
Route: DOSED FEED                                                                                                 Time: 14:20:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 5| 6| 6| 6| 7| 6| 6| 7| 7| 7|             
                             DAY ON TEST   | 6| 9| 2| 3| 3| 1| 2| 9| 3| 3| 3| 3| 3| 3| 3| 7| 0| 9| 9| 3| 0| 2| 1| 3| 3|             
                                           | 8| 9| 4| 4| 6| 8| 0| 5| 4| 6| 4| 6| 6| 6| 6| 6| 3| 4| 5| 6| 0| 1| 3| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    UNTREATD                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |                      2     1                                         X   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                                              X                           |             
      Degeneration, Multifocal             |                         1                                                |             
      Hemorrhage, Multifocal               |                2                                                         |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                   +                                                      |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                2         |             
      Cyst                                 |                               X                                          |             
      Hemorrhage, Multifocal               |          2                                            1                  |             
      Mineralization                       | 2                                                                        |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                                                   2      |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                      1           2                                       |             
      Fungus                               | 3                    3           3     3     2  3                 3      |             
      Inflammation, Acute, Suppurative     | 2                    2           2  2  2     2  3           4     2      |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Acute, Suppurative              |       1           2                                                      |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |       +     +           +        +                                   +   |             
                                            __________________________________________________________________________|             
   Eye                                     |       +           +                          +              +            |             
      Cataract                             |       2                                                                  |             
      Synechia                             |                                              2                           |             
      Cornea, Inflammation, Chronic        |                                                             3            |             
      Retina, Degeneration                 |       2                                                                  |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy, Chronic                 | 4  3  4  3  4     2  4  3  4  3  3  4  3  1  3  2  2  2  3  3  2  2  4  2|             
      Cortex, Cyst                         |       X                    X           X                                 |             
      Cortex, Mineralization               | 3                                                                        |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  29                                                               
NTP Experiment-Test: 05048-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            RHODAMINE 6G                                       Date: 05/01/97  
Route: DOSED FEED                                                                                                 Time: 14:20:05  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 7| 7| 5| 6| 6| 7| 7| 5| 6| 6| 7| 7| 6| 6| 6| 7| 7| 6| 6| 7| 7| 7|            |
                             DAY ON TEST   | 6| 9| 2| 3| 3| 7| 0| 9| 3| 3| 8| 6| 9| 3| 3| 6| 9| 9| 3| 3| 7| 9| 2| 3| 3|            |
                                           | 2| 4| 4| 6| 6| 4| 3| 4| 6| 6| 5| 7| 8| 6| 6| 1| 5| 7| 4| 6| 2| 4| 4| 6| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    UNTREATD                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Colon, Cyst                          |                                                                         X|      1     |
      Colon, Diverticulum                  |                                                       2                  |      1  2.0|
      Colon, Edema                         |                                                       2                  |      1  2.0|
      Colon, Parasite Metazoan             |          2                             2                 2               |      6  2.0|
      Rectum, Mineralization               |                                                                          |      1  2.0|
      Rectum, Parasite Metazoan            |                                                                         2|      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis, Focal                   |       1                 2  2                                1            |      7  1.6|
      Angiectasis, Multifocal              |             2                       2  2        3                    2   |      8  2.0|
      Basophilic Focus                     |             X                                                            |      2     |
      Basophilic Focus, Multiple           |                                        X                                 |      3     |
      Developmental Malformation           |                                                                         2|      5  2.0|
      Fibrosis, Focal                      |    4                                                                     |      1  4.0|
      Granuloma, Multifocal                |             2                                                            |      2  2.0|
      Hemorrhage, Focal                    |                                  2                                       |      1  2.0|
      Necrosis, Multifocal                 |                                  3                                       |      1  3.0|
      Pigmentation, Focal, Hemosiderin     |    3                                                                     |      1  3.0|
      Vacuolization Cytoplasmic, Diffuse   |                2  3                                                      |      3  2.7|
      Vacuolization Cytoplasmic, Focal     |                                                                         2|      1  2.0|
      Vacuolization Cytoplasmic, Multifocal|                                                                      1   |      1  1.0|
      Biliary Tract, Hyperplasia           |    4     2     2        3  2  2  4        1     3     2     3  2  3  2  2|     32  2.3|
      Centrilobular, Necrosis              |    1                 2  1        1              1     1        1  1      |     12  1.2|
      Hepatocyte, Hypertrophy              |                                                                      1   |      1  1.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                         +                                                |   2        |
      Fat, Necrosis, Focal                 |                         3                                                |      2  2.5|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                     1        3           2        2      |      9  1.8|
      Artery, Inflammation, Subacute       |                                        2                                 |      3  2.3|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Artery, Inflammation, Subacute       |                                        2                                 |      1  2.0|
      Forestomach, Foreign Body            |                                                                          |      1  2.0|
      Forestomach, Hyperkeratosis          |                                                                          |      1  2.0|
      Forestomach, Hyperplasia             |                                                                          |      1  2.0|
      Forestomach, Inflammation, Focal,    |                                                                          |            |
           Granulomatous                   |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  30                                                               
NTP Experiment-Test: 05048-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            RHODAMINE 6G                                       Date: 05/01/97  
Route: DOSED FEED                                                                                                 Time: 14:20:05  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 7| 7| 5| 6| 6| 7| 7| 5| 6| 6| 7| 7| 6| 6| 6| 7| 7| 6| 6| 7| 7| 7|            |
                             DAY ON TEST   | 6| 9| 2| 3| 3| 7| 0| 9| 3| 3| 8| 6| 9| 3| 3| 6| 9| 9| 3| 3| 7| 9| 2| 3| 3|            |
                                           | 2| 4| 4| 6| 6| 4| 3| 4| 6| 6| 5| 7| 8| 6| 6| 1| 5| 7| 4| 6| 2| 4| 4| 6| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    UNTREATD                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Forestomach, Inflammation, Subacute  |    2                                                                     |      2  2.0|
      Forestomach, Mineralization          |                                                                          |      1  1.0|
      Forestomach, Ulcer                   |                               3                                          |      3  2.3|
      Glandular, Mineralization            |                                                                          |      1  2.0|
      Glandular, Ulcer                     |                               2                                          |      1  2.0|
      Glandular, Ulcer, Multiple           |                3                                                         |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   1        |
      Mineralization                       |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis, Multifocal                 |    1  2  2  2  2     2  2  2     2  1  2  2           2  2  2  2  1  2  1|     35  1.8|
      Mineralization                       |                                                                          |      1  2.0|
      Atrium, Thrombosis                   |                      3                                                   |      3  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cortex, Angiectasis, Focal           |                                                                      2   |      2  2.0|
      Cortex, Congestion                   |                2                                                         |      1  2.0|
      Cortex, Degeneration, Fatty, Focal   |                                                                          |      1  1.0|
      Cortex, Degeneration, Fatty,         |                                                                          |            |
          Multifocal                       |                                                                          |      2  2.0|
      Cortex, Hyperplasia, Multifocal      |       2                                                                  |      1  2.0|
      Cortex, Hyperplasia, Multifocal,     |                                                                          |            |
           Multifocal                      |       2                                                                  |      1  2.0|
      Medulla, Hyperplasia, Focal          |    2                       1     2                                       |      6  1.8|
      Medulla, Hyperplasia, Multifocal     |                                                                          |      1  1.0|
      Medulla, Necrosis, Multifocal        |                2                                                         |      1  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |             2                                                            |      1  2.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Hyperplasia                          |                                                                          |      4  1.3|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  49        |
      Pars Distalis, Angiectasis           |          3                                                               |      6  2.8|
      Pars Distalis, Cyst                  |                   X                                         X            |      2     |
      Pars Distalis, Hemorrhage, Focal     |                                                                      1   |      1  1.0|
      Pars Distalis, Hyperplasia, Focal    |                                                                          |      2  2.0|
      Pars Distalis, Pigmentation,         |                                                                          |            |
          Hemosiderin                      |                                                                          |      4  1.8|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  31                                                               
NTP Experiment-Test: 05048-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            RHODAMINE 6G                                       Date: 05/01/97  
Route: DOSED FEED                                                                                                 Time: 14:20:05  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 7| 7| 5| 6| 6| 7| 7| 5| 6| 6| 7| 7| 6| 6| 6| 7| 7| 6| 6| 7| 7| 7|            |
                             DAY ON TEST   | 6| 9| 2| 3| 3| 7| 0| 9| 3| 3| 8| 6| 9| 3| 3| 6| 9| 9| 3| 3| 7| 9| 2| 3| 3|            |
                                           | 2| 4| 4| 6| 6| 4| 3| 4| 6| 6| 5| 7| 8| 6| 6| 1| 5| 7| 4| 6| 2| 4| 4| 6| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    UNTREATD                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ultimobranchial Cyst                 |                                                                          |      1     |
      C-Cell, Hyperplasia, Focal           |                                                                          |      1  2.0|
      C-Cell, Hyperplasia, Multifocal      |                                                                          |      1  2.0|
      Follicle, Cyst                       |                                     X                    X               |      2     |
      Follicle, Hyperplasia, Cystic, Focal |                         2                                                |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Acute, Suppurative     | 2                                                                        |      4  2.5|
      Inflammation, Subacute               |          2                                                               |      2  2.0|
      Duct, Cyst                           |                                           X                    X         |      3     |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                                             4            |      1  4.0|
      Inflammation, Acute, Suppurative     | 1        3        2  2           1  1        4  2        1              2|     19  1.9|
      Inflammation, Chronic                |                         1  1                                             |      5  1.2|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Atrophy                              |       2                                                                  |      2  2.5|
      Inflammation, Acute, Suppurative     |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   | +  +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +     +  +  +  +|  44        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Iliac, Ectasia                       |                                              4                           |      1  4.0|
      Inguinal, Hyperplasia                |                                              2                           |      1  2.0|
      Mandibular, Ectasia                  |    2                                         3              2  2        2|      7  2.3|
      Mediastinal, Hyperplasia             |                         2                                                |      1  2.0|
      Mesenteric, Angiectasis              |                                        3                                 |      2  2.5|
      Mesenteric, Congestion               |                                                                          |      1  2.0|
      Mesenteric, Ectasia                  |                      4                    2                              |      2  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |       2                                                                  |      2  2.5|
      Developmental Malformation           |                                                       2                  |      1  2.0|
      Fibrosis                             |                2                 2                                       |      7  2.4|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  32                                                               
NTP Experiment-Test: 05048-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            RHODAMINE 6G                                       Date: 05/01/97  
Route: DOSED FEED                                                                                                 Time: 14:20:05  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 7| 7| 5| 6| 6| 7| 7| 5| 6| 6| 7| 7| 6| 6| 6| 7| 7| 6| 6| 7| 7| 7|            |
                             DAY ON TEST   | 6| 9| 2| 3| 3| 7| 0| 9| 3| 3| 8| 6| 9| 3| 3| 6| 9| 9| 3| 3| 7| 9| 2| 3| 3|            |
                                           | 2| 4| 4| 6| 6| 4| 3| 4| 6| 6| 5| 7| 8| 6| 6| 1| 5| 7| 4| 6| 2| 4| 4| 6| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    UNTREATD                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Hematopoietic Cell Proliferation     |                      2                                                   |      1  2.0|
      Capsule, Fibrosis, Focal             |                                        1                                 |      1  1.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Duct, Cyst                           |          X     X  X                          X                    X  X  X|     10     |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Alopecia                             |                                                                          |      1     |
      Cyst Epithelial Inclusion            |                                                                         X|      1     |
      Hyperkeratosis, Focal                |                                        3                                 |      1  3.0|
      Hyperplasia, Focal                   |                                        2                                 |      1  2.0|
      Inflammation, Acute, Focal,          |                                                                          |            |
          Suppurative                      |                                                                      2   |      2  2.0|
      Inflammation, Focal, Granulomatous   |                                        2                                 |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrous Osteodystrophy               |                                                                          |      3  1.5|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression                          |                                                                          |      1     |
      Degeneration, Multifocal             |                                     2                                    |      2  1.5|
      Hemorrhage, Multifocal               |                               3                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                                                                          |      1  2.0|
      Cyst                                 |                                                                          |      1     |
      Hemorrhage, Multifocal               |                                                                          |      2  1.5|
      Mineralization                       |                                                                          |      1  2.0|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Foreign Body                         |                3                                                         |      3  2.0|
      Fungus                               |    3           3                 3              3                        |     11  2.9|
      Inflammation, Acute, Suppurative     |    2           3                 2              2                    1   |     14  2.2|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  33                                                               
NTP Experiment-Test: 05048-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            RHODAMINE 6G                                       Date: 05/01/97  
Route: DOSED FEED                                                                                                 Time: 14:20:05  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 7| 7| 5| 6| 6| 7| 7| 5| 6| 6| 7| 7| 6| 6| 6| 7| 7| 6| 6| 7| 7| 7|            |
                             DAY ON TEST   | 6| 9| 2| 3| 3| 7| 0| 9| 3| 3| 8| 6| 9| 3| 3| 6| 9| 9| 3| 3| 7| 9| 2| 3| 3|            |
                                           | 2| 4| 4| 6| 6| 4| 3| 4| 6| 6| 5| 7| 8| 6| 6| 1| 5| 7| 4| 6| 2| 4| 4| 6| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    UNTREATD                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Acute, Suppurative              |                                     1                                    |      3  1.3|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |       +  +  +              +           +              +  +     +     +   |  14        |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   4        |
      Cataract                             |                                                                          |      1  2.0|
      Synechia                             |                                                                          |      1  2.0|
      Cornea, Inflammation, Chronic        |                                                                          |      1  3.0|
      Retina, Degeneration                 |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Nephropathy, Chronic                 | 3  3  4  2  3  2  2  2  3  3  2  2  3  4  3  3  2  2  2  1  2  3  2  4  2|     49  2.7|
      Cortex, Cyst                         |                                                                          |      3     |
      Cortex, Mineralization               |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  34                                                               
NTP Experiment-Test: 05048-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            RHODAMINE 6G                                       Date: 05/01/97  
Route: DOSED FEED                                                                                                 Time: 14:20:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 4| 6| 7| 7| 7| 4| 6| 6| 7| 7|             
                             DAY ON TEST   | 5| 0| 2| 3| 3| 5| 9| 3| 3| 3| 4| 9| 3| 3| 3| 6| 9| 3| 3| 3| 5| 5| 5| 3| 3|             
                                           | 3| 8| 7| 3| 3| 0| 8| 3| 3| 3| 3| 9| 3| 3| 3| 8| 8| 3| 3| 3| 3| 7| 7| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.025%                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cecum, Inflammation, Subacute        | 2                                                                       2|             
      Colon, Parasite Metazoan             |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis, Focal                   |    2                 1     1                    1     2                  |             
      Angiectasis, Multifocal              |          2  1                                      2                 1   |             
      Basophilic Focus                     |             X  X     X                                                   |             
      Basophilic Focus, Multiple           |                            X        X                                    |             
      Clear Cell Focus                     |                                                                         X|             
      Degeneration, Fatty, Focal           |                                                                   2      |             
      Developmental Malformation           | 2     2              X     2                                             |             
      Eosinophilic Focus, Multiple         |                                                                          |             
      Granuloma, Focal                     |                      1                                                   |             
      Granuloma, Multifocal                |             2                                            1               |             
      Necrosis, Focal                      |                                                                          |             
      Necrosis, Multifocal                 |                                                 2                        |             
      Vacuolization Cytoplasmic, Diffuse   |                                     1                                    |             
      Biliary Tract, Hyperplasia           | 2  3  1  2  2  2           2  2  3  2  1  1  2  1  3  2  1  2  2  3  3  2|             
      Centrilobular, Necrosis              |    1                          1  2           1     1  1     1        1   |             
      Hepatocyte, Hypertrophy              | 3           1                    1                                       |             
                                            __________________________________________________________________________|             
   Mesentery                               | +              +                          +                              |             
      Hemorrhage                           | 2              2                                                         |             
      Inflammation, Diffuse, Subacute      | 3                                                                        |             
      Fat, Necrosis, Focal                 | 3                                                                        |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |    2              1              3        3  2     1                     |             
      Artery, Hypertrophy                  |                                                                          |             
      Artery, Inflammation, Subacute       |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Subacute               | 2                                                                        |             
      Forestomach, Hyperkeratosis          | 2                                                     2                  |             
      Forestomach, Hyperplasia             | 2                                                     2                  |             
      Forestomach, Inflammation, Subacute  |                                                 1                        |             
      Forestomach, Ulcer                   |                                                       4                  |             
      Glandular, Erosion                   |                                                             2            |             
      Glandular, Mineralization            |                               2                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                              +                           |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  35                                                               
NTP Experiment-Test: 05048-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            RHODAMINE 6G                                       Date: 05/01/97  
Route: DOSED FEED                                                                                                 Time: 14:20:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 4| 6| 7| 7| 7| 4| 6| 6| 7| 7|             
                             DAY ON TEST   | 5| 0| 2| 3| 3| 5| 9| 3| 3| 3| 4| 9| 3| 3| 3| 6| 9| 3| 3| 3| 5| 5| 5| 3| 3|             
                                           | 3| 8| 7| 3| 3| 0| 8| 3| 3| 3| 3| 9| 3| 3| 3| 8| 8| 3| 3| 3| 3| 7| 7| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.025%                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                               +                                          |             
      Mineralization                       |                               2                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis, Multifocal                 | 2  2  1  2  3  2  2  2     2  2  2  2     2     1  2  1        2  2  1  1|             
      Mineralization                       |                               1                                          |             
      Atrium, Thrombosis                   |    3                                                                     |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cortex, Degeneration, Diffuse, Fatty |                                                                          |             
      Cortex, Degeneration, Fatty, Focal   |          2                                            2     2            |             
      Cortex, Degeneration, Fatty,         |                                                                          |             
          Multifocal                       |                                                                          |             
      Cortex, Hemorrhage, Multifocal       |                                                                          |             
      Cortex, Hyperplasia, Focal           |          2                                                               |             
      Cortex, Necrosis, Diffuse            |                                                 4                        |             
      Cortex, Necrosis, Multifocal         |                                                                          |             
      Medulla, Hematopoietic Cell          |                                                                          |             
          Proliferation                    |                2              2                                          |             
      Medulla, Hyperplasia, Focal          |                      2                                                   |             
      Medulla, Hyperplasia, Multifocal     |                                                                         2|             
      Medulla, Necrosis, Diffuse           |                                                 4                        |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +|             
      Hyperplasia                          |                      1        1                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                      2  3  3           2           2           3     3   |             
      Pars Distalis, Cyst                  |                               2                                          |             
      Pars Distalis, Hemorrhage, Focal     |                                                                          |             
      Pars Distalis, Hyperplasia, Focal    |                2                                                         |             
      Pars Distalis, Pigmentation,         |                                                                          |             
          Hemosiderin                      |                      1  1                                      2         |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ultimobranchial Cyst                 |                                                                          |             
      C-Cell, Hyperplasia, Focal           |                                                                          |             
      C-Cell, Hyperplasia, Multifocal      |                                                                          |             
      Follicle, Cyst                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  36                                                               
NTP Experiment-Test: 05048-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            RHODAMINE 6G                                       Date: 05/01/97  
Route: DOSED FEED                                                                                                 Time: 14:20:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 4| 6| 7| 7| 7| 4| 6| 6| 7| 7|             
                             DAY ON TEST   | 5| 0| 2| 3| 3| 5| 9| 3| 3| 3| 4| 9| 3| 3| 3| 6| 9| 3| 3| 3| 5| 5| 5| 3| 3|             
                                           | 3| 8| 7| 3| 3| 0| 8| 3| 3| 3| 3| 9| 3| 3| 3| 8| 8| 3| 3| 3| 3| 7| 7| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.025%                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  M  +|             
      Hyperplasia                          |                                                                          |             
      Inflammation, Acute, Suppurative     |                   3                          3                 2         |             
      Inflammation, Subacute               |                                                                          |             
      Duct, Cyst                           |                   X        X                 X                           |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                            X                                             |             
      Edema                                |                                                                          |             
      Inflammation, Acute, Suppurative     | 3  1  3        1     3  2        2           4  4              2     3   |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Subacute               |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |                      +                          +                        |             
      Inflammation, Acute, Suppurative     |                      3                                                   |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                               3                                          |             
      Atrophy                              |                                                       3     3            |             
      Mineralization                       |                               2                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                               3                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mandibular, Congestion               | 2                                                                        |             
      Mandibular, Ectasia                  |          2                       1                          2        2   |             
      Mediastinal, Congestion              |       1                                                                  |             
      Mesenteric, Angiectasis              | 2                                                                        |             
      Mesenteric, Ectasia                  |                                        2                                 |             
      Pancreatic, Ectasia                  |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Congestion                           |                                                                          |             
      Fibrosis                             |    2     2     3     2                                               2   |             
      Hematopoietic Cell Proliferation     |       3        3              3                 3                        |             
      Necrosis, Focal                      |                                                                          |             
      Pigmentation, Hemosiderin            |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Cyst                                 |                                                       X                  |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Granuloma                            |                                  3                                       |             
      Inflammation, Chronic, Focal         |                                                                         3|             
      Pigmentation, Hemosiderin            |                                                                         3|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  37                                                               
NTP Experiment-Test: 05048-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            RHODAMINE 6G                                       Date: 05/01/97  
Route: DOSED FEED                                                                                                 Time: 14:20:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 4| 6| 7| 7| 7| 4| 6| 6| 7| 7|             
                             DAY ON TEST   | 5| 0| 2| 3| 3| 5| 9| 3| 3| 3| 4| 9| 3| 3| 3| 6| 9| 3| 3| 3| 5| 5| 5| 3| 3|             
                                           | 3| 8| 7| 3| 3| 0| 8| 3| 3| 3| 3| 9| 3| 3| 3| 8| 8| 3| 3| 3| 3| 7| 7| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.025%                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Duct, Cyst                           |    X                 X  X     X  X                 X           X  X  X  X|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                               2                                          |             
      Hyperkeratosis, Focal                |                                                    2                     |             
      Hyperplasia, Focal                   |                                                    3                     |             
      Inflammation, Acute, Focal,          |                                                                          |             
          Suppurative                      |                      2                                                   |             
      Inflammation, Chronic, Focal         |                                                                          |             
      Inflammation, Focal, Granulomatous   |                                                                          |             
      Inflammation, Focal, Subacute        |                                                    2                     |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |                      X                                                   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bacterium                            |                                                                          |             
      Compression                          |                                                                          |             
      Degeneration, Multifocal             |                   2                                            2         |             
      Hemorrhage, Multifocal               |                                                             3            |             
      Necrosis, Focal                      |                                                                          |             
      Thrombosis                           |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                +         |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Foreign Body                         |                   1                                                      |             
      Granuloma                            |                   1                                                      |             
      Inflammation, Multifocal, Subacute   |                                                                          |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                2                                                         |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +|             
      Foreign Body                         |                         1                                2           2   |             
      Fungus                               |                      3        3                          3           3   |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Acute, Suppurative     |          2           2  2     2                          2           2   |             
      Inflammation, Chronic                |                                                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Acute, Suppurative              |                                                                2         |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Subacute               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  38                                                               
NTP Experiment-Test: 05048-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            RHODAMINE 6G                                       Date: 05/01/97  
Route: DOSED FEED                                                                                                 Time: 14:20:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 4| 6| 7| 7| 7| 4| 6| 6| 7| 7|             
                             DAY ON TEST   | 5| 0| 2| 3| 3| 5| 9| 3| 3| 3| 4| 9| 3| 3| 3| 6| 9| 3| 3| 3| 5| 5| 5| 3| 3|             
                                           | 3| 8| 7| 3| 3| 0| 8| 3| 3| 3| 3| 9| 3| 3| 3| 8| 8| 3| 3| 3| 3| 7| 7| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.025%                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |          +  +        +     +  +     +  +  +                             +|             
                                            __________________________________________________________________________|             
   Eye                                     |          +  +        +  +        +  +  +  +  +        +  +     +  +  +  +|             
      Cataract                             |          2  2        3  2        1  2  4  3           3  3     3  2      |             
      Hemorrhage                           |                                        2                          2      |             
      Retina, Degeneration                 |          2  2        3  2        1  2  4  3  2        3  3     3  2  3  1|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydronephrosis                       |                                                                          |             
      Inflammation, Acute, Suppurative     |                                                                          |             
      Nephropathy, Chronic                 | 2  3  3  3  3  2  2  4  2  3  3  3  2  2  2  1  2  3  2  3  1  4  3  2  2|             
      Cortex, Cyst                         |                      X              X                                    |             
      Cortex, Mineralization               |                               3                                          |             
      Papilla, Necrosis                    |                                                                          |             
      Pelvis, Inflammation, Acute,         |                                                                          |             
          Suppurative                      | 2                                                                        |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                             4            |             
      Inflammation, Acute, Suppurative     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  39                                                               
NTP Experiment-Test: 05048-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            RHODAMINE 6G                                       Date: 05/01/97  
Route: DOSED FEED                                                                                                 Time: 14:20:05  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 6| 7| 7| 7| 6| 7| 7| 7| 7| 3| 6| 6| 7| 7| 5| 6| 7| 7| 7| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 8| 9| 1| 3| 3| 9| 3| 3| 3| 3| 6| 6| 8| 3| 3| 7| 6| 3| 3| 3| 2| 2| 3| 3| 3|            |
                                           | 2| 4| 5| 3| 3| 5| 3| 3| 3| 3| 7| 4| 0| 3| 3| 6| 7| 3| 3| 3| 9| 2| 3| 4| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
    0.025%                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cecum, Inflammation, Subacute        |                                                                          |      2  2.0|
      Colon, Parasite Metazoan             |                                                       2                  |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis, Focal                   |                                        2  2              1               |      8  1.5|
      Angiectasis, Multifocal              |                                                       3        1         |      6  1.7|
      Basophilic Focus                     |                         X                 X                              |      5     |
      Basophilic Focus, Multiple           |                                                                          |      2     |
      Clear Cell Focus                     |                                                                          |      1     |
      Degeneration, Fatty, Focal           |                                                                          |      1  2.0|
      Developmental Malformation           |                                                             2            |      5  2.0|
      Eosinophilic Focus, Multiple         |                                                                      3   |      1  3.0|
      Granuloma, Focal                     |                                                                          |      1  1.0|
      Granuloma, Multifocal                |                                                                          |      2  1.5|
      Necrosis, Focal                      |                                                             2            |      1  2.0|
      Necrosis, Multifocal                 |                                                                          |      1  2.0|
      Vacuolization Cytoplasmic, Diffuse   |       2              2           1                          2            |      5  1.6|
      Biliary Tract, Hyperplasia           |       3        2  2     1  3     3  2  1  2  2  2  3     2  2  2  2  3   |     39  2.1|
      Centrilobular, Necrosis              |       1                          1  2              1                 1   |     13  1.2|
      Hepatocyte, Hypertrophy              |                                                    1                     |      4  1.5|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                   +      |   4        |
      Hemorrhage                           |                                                                          |      2  2.0|
      Inflammation, Diffuse, Subacute      |                                                                          |      1  3.0|
      Fat, Necrosis, Focal                 |                                                                   3      |      2  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |       2                                1        2     1     3            |     11  1.9|
      Artery, Hypertrophy                  |          4                                                               |      1  4.0|
      Artery, Inflammation, Subacute       |                                                                         2|      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |                                                             2            |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Subacute               |                                                                          |      1  2.0|
      Forestomach, Hyperkeratosis          | 1                                                        1               |      4  1.5|
      Forestomach, Hyperplasia             | 1                                                        1               |      4  1.5|
      Forestomach, Inflammation, Subacute  |                                                          2               |      2  1.5|
      Forestomach, Ulcer                   |                                                                          |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  40                                                               
NTP Experiment-Test: 05048-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            RHODAMINE 6G                                       Date: 05/01/97  
Route: DOSED FEED                                                                                                 Time: 14:20:05  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 6| 7| 7| 7| 6| 7| 7| 7| 7| 3| 6| 6| 7| 7| 5| 6| 7| 7| 7| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 8| 9| 1| 3| 3| 9| 3| 3| 3| 3| 6| 6| 8| 3| 3| 7| 6| 3| 3| 3| 2| 2| 3| 3| 3|            |
                                           | 2| 4| 5| 3| 3| 5| 3| 3| 3| 3| 7| 4| 0| 3| 3| 6| 7| 3| 3| 3| 9| 2| 3| 4| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
    0.025%                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Glandular, Erosion                   |                                                                          |      1  2.0|
      Glandular, Mineralization            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Tongue                                  |             +                                                            |   2        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                +         |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   1        |
      Mineralization                       |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis, Multifocal                 | 2  1  1        2     2  2  1     2  1  1  2  2  1  2  1  2     1  2  2  2|     40  1.7|
      Mineralization                       |                                                                          |      1  1.0|
      Atrium, Thrombosis                   |                                     3                                    |      2  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cortex, Degeneration, Diffuse, Fatty |                                  2                                       |      1  2.0|
      Cortex, Degeneration, Fatty, Focal   |                               1        1                                2|      6  1.7|
      Cortex, Degeneration, Fatty,         |                                                                          |            |
          Multifocal                       |                                                                   2      |      1  2.0|
      Cortex, Hemorrhage, Multifocal       |                                              3                           |      1  3.0|
      Cortex, Hyperplasia, Focal           |                                                    1                     |      2  1.5|
      Cortex, Necrosis, Diffuse            |                                                                          |      1  4.0|
      Cortex, Necrosis, Multifocal         |                               2              3                           |      2  2.5|
      Medulla, Hematopoietic Cell          |                                                                          |            |
          Proliferation                    |                                                                          |      2  2.0|
      Medulla, Hyperplasia, Focal          |                                                 3                        |      2  2.5|
      Medulla, Hyperplasia, Multifocal     |                                                                          |      1  2.0|
      Medulla, Necrosis, Diffuse           |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hyperplasia                          |                                                          1               |      3  1.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Pars Distalis, Angiectasis           |    2     2           2                                   3               |     11  2.5|
      Pars Distalis, Cyst                  |                                                                          |      1  2.0|
      Pars Distalis, Hemorrhage, Focal     |                2                                                         |      1  2.0|
      Pars Distalis, Hyperplasia, Focal    |                                                             2            |      2  2.0|
      Pars Distalis, Pigmentation,         |                                                                          |            |
          Hemosiderin                      |    1     1           1                                   1               |      7  1.1|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  41                                                               
NTP Experiment-Test: 05048-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            RHODAMINE 6G                                       Date: 05/01/97  
Route: DOSED FEED                                                                                                 Time: 14:20:05  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 6| 7| 7| 7| 6| 7| 7| 7| 7| 3| 6| 6| 7| 7| 5| 6| 7| 7| 7| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 8| 9| 1| 3| 3| 9| 3| 3| 3| 3| 6| 6| 8| 3| 3| 7| 6| 3| 3| 3| 2| 2| 3| 3| 3|            |
                                           | 2| 4| 5| 3| 3| 5| 3| 3| 3| 3| 7| 4| 0| 3| 3| 6| 7| 3| 3| 3| 9| 2| 3| 4| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
    0.025%                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Ultimobranchial Cyst                 |                                  X                                       |      1     |
      C-Cell, Hyperplasia, Focal           |                                                                   2      |      1  2.0|
      C-Cell, Hyperplasia, Multifocal      |                                  2                                       |      1  2.0|
      Follicle, Cyst                       |                                        X                                 |      1     |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | M  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +|  43        |
      Hyperplasia                          |             3                                                            |      1  3.0|
      Inflammation, Acute, Suppurative     |                                     2           2                 2      |      6  2.3|
      Inflammation, Subacute               |             2                                                            |      1  2.0|
      Duct, Cyst                           |                                                                          |      3     |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                                                          |      1     |
      Edema                                | 2                                                                        |      1  2.0|
      Inflammation, Acute, Suppurative     |    1     3     2     1        3        2           1        4            |     19  2.4|
      Inflammation, Chronic                | 2                                                                        |      1  2.0|
      Inflammation, Subacute               |                                                          4               |      1  4.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |                                                                          |   2        |
      Inflammation, Acute, Suppurative     |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                                          |      1  3.0|
      Atrophy                              |             3                                   3                        |      4  3.0|
      Mineralization                       |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   | +        +  +  +  +  +  +  +     +     +  +     +  +  +  +  +  +  +  +  +|  44        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                   2                                                      |      2  2.5|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mandibular, Congestion               |                                                                          |      1  2.0|
      Mandibular, Ectasia                  |                                           2              2               |      6  1.8|
      Mediastinal, Congestion              |                                                                          |      1  1.0|
      Mesenteric, Angiectasis              |                                                                          |      1  2.0|
      Mesenteric, Ectasia                  |                                                       2     2     4      |      4  2.5|
      Pancreatic, Ectasia                  |                                                          1               |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  42                                                               
NTP Experiment-Test: 05048-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            RHODAMINE 6G                                       Date: 05/01/97  
Route: DOSED FEED                                                                                                 Time: 14:20:05  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 6| 7| 7| 7| 6| 7| 7| 7| 7| 3| 6| 6| 7| 7| 5| 6| 7| 7| 7| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 8| 9| 1| 3| 3| 9| 3| 3| 3| 3| 6| 6| 8| 3| 3| 7| 6| 3| 3| 3| 2| 2| 3| 3| 3|            |
                                           | 2| 4| 5| 3| 3| 5| 3| 3| 3| 3| 7| 4| 0| 3| 3| 6| 7| 3| 3| 3| 9| 2| 3| 4| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
    0.025%                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                     3                                    |      1  3.0|
      Congestion                           |                                                       2                  |      1  2.0|
      Fibrosis                             |                      3                                   2               |      7  2.3|
      Hematopoietic Cell Proliferation     |                   2                                                      |      5  2.8|
      Necrosis, Focal                      |                                  3                                       |      1  3.0|
      Pigmentation, Hemosiderin            |                               3                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Cyst                                 |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M|  46        |
      Granuloma                            |                                                                          |      1  3.0|
      Inflammation, Chronic, Focal         |                                                                          |      1  3.0|
      Pigmentation, Hemosiderin            |                                                                          |      1  3.0|
      Duct, Cyst                           |    X  X  X  X     X  X  X        X              X        X  X        X   |     22     |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Abscess                              |                                                                          |      1  2.0|
      Hyperkeratosis, Focal                |                                                                          |      1  2.0|
      Hyperplasia, Focal                   |                   4                                                      |      2  3.5|
      Inflammation, Acute, Focal,          |                                                                          |            |
          Suppurative                      |                                                                          |      1  2.0|
      Inflammation, Chronic, Focal         |                      3                                                   |      1  3.0|
      Inflammation, Focal, Granulomatous   |             2                                                            |      1  2.0|
      Inflammation, Focal, Subacute        |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrous Osteodystrophy               |                                                          X               |      2     |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Bacterium                            |                                     2                                    |      1  2.0|
      Compression                          |          X                                                               |      1     |
      Degeneration, Multifocal             |       2        2                    1           1                 2      |      7  1.7|
      Hemorrhage, Multifocal               |                                  3                                       |      2  3.0|
      Necrosis, Focal                      |                                     2                                    |      1  2.0|
      Thrombosis                           |                                     3                                    |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spinal Cord                             | +                                                              +         |   3        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  43                                                               
NTP Experiment-Test: 05048-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            RHODAMINE 6G                                       Date: 05/01/97  
Route: DOSED FEED                                                                                                 Time: 14:20:05  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 6| 7| 7| 7| 6| 7| 7| 7| 7| 3| 6| 6| 7| 7| 5| 6| 7| 7| 7| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 8| 9| 1| 3| 3| 9| 3| 3| 3| 3| 6| 6| 8| 3| 3| 7| 6| 3| 3| 3| 2| 2| 3| 3| 3|            |
                                           | 2| 4| 5| 3| 3| 5| 3| 3| 3| 3| 7| 4| 0| 3| 3| 6| 7| 3| 3| 3| 9| 2| 3| 4| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
    0.025%                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           | 3                                                                        |      1  3.0|
      Foreign Body                         |                                                                          |      1  1.0|
      Granuloma                            |                                                                          |      1  1.0|
      Inflammation, Multifocal, Subacute   |                2                                                         |      1  2.0|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | M  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
      Foreign Body                         |    2                                2                 2           1      |      7  1.7|
      Fungus                               |    3                 4              4           3     3     3            |     10  3.2|
      Hemorrhage                           |    2                 2                                                   |      2  2.0|
      Inflammation, Acute, Suppurative     |    2                 3  2           2           2     2     3     1      |     14  2.1|
      Inflammation, Chronic                |                                                                3         |      1  3.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Acute, Suppurative              |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Subacute               |                                                                   3      |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |          +        +  +     +                             +     +     +  +|  17        |
                                            __________________________________________________________________________|____________|
   Eye                                     |                   +     +  +                                             |  18        |
      Cataract                             |                         4                                                |     13  2.6|
      Hemorrhage                           |                                                                          |      2  2.0|
      Retina, Degeneration                 |                         4  1                                             |     17  2.4|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hydronephrosis                       | 2                                                                        |      1  2.0|
      Inflammation, Acute, Suppurative     |                               4                                          |      1  4.0|
      Nephropathy, Chronic                 | 2  1  2  3  3  3  2  3  3  3     3  3  3  3  2  2  3  4  4  2  2  3  1  3|     49  2.6|
      Cortex, Cyst                         |                                                                          |      2     |
      Cortex, Mineralization               |                                     2                                    |      2  2.5|
      Papilla, Necrosis                    |                               4                                          |      1  4.0|
      Pelvis, Inflammation, Acute,         |                                                                          |            |
          Suppurative                      |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                                                          |      1  4.0|
      Inflammation, Acute, Suppurative     |                               4                                          |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  44                                                               
NTP Experiment-Test: 05048-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            RHODAMINE 6G                                       Date: 05/01/97  
Route: DOSED FEED                                                                                                 Time: 14:20:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 6| 7| 6| 6| 6| 7| 7| 6| 6| 6| 7| 7| 5| 6| 7| 7| 7| 6| 6| 7| 7| 7|             
                             DAY ON TEST   | 2| 4| 6| 9| 3| 6| 6| 9| 3| 3| 5| 6| 9| 3| 3| 2| 9| 2| 3| 3| 1| 9| 3| 3| 3|             
                                           | 0| 7| 8| 2| 4| 0| 3| 5| 5| 5| 4| 2| 6| 4| 5| 2| 2| 2| 5| 5| 9| 4| 5| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.012%                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cecum, Parasite Metazoan             | 2                                                                        |             
      Colon, Parasite Metazoan             | 2                             2                             2  2         |             
      Rectum, Mineralization               |                                                                          |             
      Rectum, Parasite Metazoan            |                                                          2               |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Peyer's Patch, Mineralization, Focal |                         2                                                |             
      Peyer's Patch, Necrosis, Focal       |                         X                                                |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis, Focal                   |                                                                   3      |             
      Angiectasis, Multifocal              |                                                          2               |             
      Basophilic Focus                     |                                                                   X      |             
      Basophilic Focus, Multiple           |                                                                          |             
      Congestion                           |                2                          2        2                     |             
      Developmental Malformation           |                                                                   2      |             
      Eosinophilic Focus                   |                                                                          |             
      Granuloma, Multifocal                |                                                                          |             
      Hematopoietic Cell Proliferation     | 2                                                                        |             
      Hemorrhage, Multifocal               |                                     2                                    |             
      Hepatodiaphragmatic Nodule           |                                                                          |             
      Necrosis, Multifocal                 |                                                                          |             
      Pigmentation, Hemosiderin, Multifocal|                                     2                                    |             
      Thrombosis                           |                                                                          |             
      Vacuolization Cytoplasmic, Diffuse   |                               3                                          |             
      Vacuolization Cytoplasmic, Focal     |                      3                                                   |             
      Vacuolization Cytoplasmic, Multifocal|                                                                          |             
      Biliary Tract, Hyperplasia           | 2  3  2  1  2  1  2  2     1  2  2  2     3        2        3  2  2      |             
      Centrilobular, Necrosis              |    1     1  2  3  2           1     1        4                           |             
      Hepatocyte, Hypertrophy              |                                     1                                    |             
                                            __________________________________________________________________________|             
   Mesentery                               |                         +        +           +                           |             
      Fat, Necrosis, Focal                 |                         2        3                                       |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 2     2     2  3           2        3                             1     2|             
      Acinus, Hyperplasia                  |                                                                          |             
      Artery, Inflammation, Subacute       |                            3                             3               |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Artery, Inflammation, Subacute       |                                                                          |             
      Forestomach, Edema                   |             2                                                            |             
      Forestomach, Hyperkeratosis          |          2                                                               |             
      Forestomach, Hyperplasia             |          2                                                               |             
      Forestomach, Inflammation, Subacute  |          2                                                               |             
      Forestomach, Mineralization          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  45                                                               
NTP Experiment-Test: 05048-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            RHODAMINE 6G                                       Date: 05/01/97  
Route: DOSED FEED                                                                                                 Time: 14:20:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 6| 7| 6| 6| 6| 7| 7| 6| 6| 6| 7| 7| 5| 6| 7| 7| 7| 6| 6| 7| 7| 7|             
                             DAY ON TEST   | 2| 4| 6| 9| 3| 6| 6| 9| 3| 3| 5| 6| 9| 3| 3| 2| 9| 2| 3| 3| 1| 9| 3| 3| 3|             
                                           | 0| 7| 8| 2| 4| 0| 3| 5| 5| 5| 4| 2| 6| 4| 5| 2| 2| 2| 5| 5| 9| 4| 5| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.012%                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Forestomach, Ulcer                   |                                                                          |             
      Glandular, Edema                     |             2                                                            |             
      Glandular, Erosion                   |                                                             2            |             
      Glandular, Erosion, Multiple         |                                                                          |             
      Glandular, Mineralization            |                                        2           2  2                  |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
      Mineralization                       |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bacterium                            |                                                                          |             
      Fibrosis, Multifocal                 | 2     2  1  2  1  1  1  1  1        2  3  3     1  1  2     2  1  1  1   |             
      Inflammation, Acute, Suppurative     |                                                                          |             
      Mineralization                       |                                                                          |             
      Atrium, Thrombosis                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                                                          |             
      Cortex, Degeneration, Fatty, Focal   |             1        1                 2              2                  |             
      Medulla, Hematopoietic Cell          |                                                                          |             
          Proliferation                    | 2                                                                        |             
      Medulla, Hyperplasia, Focal          |                2                                2                        |             
      Medulla, Hyperplasia, Multifocal     |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                 2                        |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Hyperplasia                          |                                        2        1                        |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                               1           1  2        3                  |             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hyperplasia, Focal    |                                           3                 3  2     2   |             
      Pars Distalis, Pigmentation,         |                                                                          |             
          Hemosiderin                      |                               1              1                           |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Ultimobranchial Cyst                 |    X                 X                                                   |             
      C-Cell, Hyperplasia, Focal           |                      1     3                                             |             
      Follicle, Cyst                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  46                                                               
NTP Experiment-Test: 05048-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            RHODAMINE 6G                                       Date: 05/01/97  
Route: DOSED FEED                                                                                                 Time: 14:20:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 6| 7| 6| 6| 6| 7| 7| 6| 6| 6| 7| 7| 5| 6| 7| 7| 7| 6| 6| 7| 7| 7|             
                             DAY ON TEST   | 2| 4| 6| 9| 3| 6| 6| 9| 3| 3| 5| 6| 9| 3| 3| 2| 9| 2| 3| 3| 1| 9| 3| 3| 3|             
                                           | 0| 7| 8| 2| 4| 0| 3| 5| 5| 5| 4| 2| 6| 4| 5| 2| 2| 2| 5| 5| 9| 4| 5| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.012%                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute, Suppurative     |                                  3                    2  2        3      |             
      Inflammation, Chronic                |                                                                          |             
      Duct, Cyst                           |          X     X                                         X        X      |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Concretion                           |                                  2                                       |             
      Fibrosis                             |                                           4                              |             
      Inflammation, Acute, Suppurative     |       1        1              3                             3  2         |             
      Inflammation, Chronic                |                      2                                                   |             
      Inflammation, Subacute               |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |                                                       +     +            |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                         2                       3                        |             
      Mineralization                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Deep Cervical, Congestion            |                                                                          |             
      Lumbar, Ectasia                      |                      3                                                   |             
      Mandibular, Ectasia                  |                                                                          |             
      Mesenteric, Ectasia                  |       2                                                                 1|             
      Pancreatic, Ectasia                  |                                                                          |             
      Pancreatic, Hyperplasia              |                                           2                              |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Fibrosis                             |                         3              2  3                       2      |             
      Hematopoietic Cell Proliferation     |                      2           2                          3            |             
      Inflammation, Acute, Suppurative     |                                                                          |             
      Necrosis, Focal                      |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  +  M  +  +|             
      Cyst                                 |                                                                          |             
      Mediastinum, Inflammation, Acute,    |                                                                          |             
           Suppurative                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Duct, Cyst                           |          X  X     X           X              X  X  X  X     X  X        X|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                                                          |             
      Hyperkeratosis, Focal                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  47                                                               
NTP Experiment-Test: 05048-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            RHODAMINE 6G                                       Date: 05/01/97  
Route: DOSED FEED                                                                                                 Time: 14:20:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 6| 7| 6| 6| 6| 7| 7| 6| 6| 6| 7| 7| 5| 6| 7| 7| 7| 6| 6| 7| 7| 7|             
                             DAY ON TEST   | 2| 4| 6| 9| 3| 6| 6| 9| 3| 3| 5| 6| 9| 3| 3| 2| 9| 2| 3| 3| 1| 9| 3| 3| 3|             
                                           | 0| 7| 8| 2| 4| 0| 3| 5| 5| 5| 4| 2| 6| 4| 5| 2| 2| 2| 5| 5| 9| 4| 5| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.012%                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hyperplasia, Focal                   |                                                                          |             
      Hyperplasia                          |                                           3                              |             
      Inflammation, Acute, Focal,          |                                                                          |             
          Suppurative                      |                                                             4        2   |             
      Inflammation, Chronic, Focal         |                                                                          |             
      Inflammation, Focal, Subacute        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |                                        X                                 |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                                                                          |             
      Degeneration, Multifocal             |                                                 1           2            |             
      Hemorrhage, Multifocal               |                   2                                                      |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                    2                     |             
      Hemorrhage, Multifocal               |                                                                          |             
      Hyperplasia, Histiocytic             |                                                                          |             
      Inflammation, Multifocal, Subacute   |                   2                                                      |             
      Mineralization                       |                                                                          |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                   3                                                      |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         | 2     3              2                                               2   |             
      Fungus                               | 2  3  3     3     3  3        3                          3        3  3   |             
      Inflammation, Acute, Suppurative     | 2  2  2     1     2  1        2                          2        2  1   |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Acute, Suppurative              |                         1                                                |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |    +                       +           +                             +   |             
                                            __________________________________________________________________________|             
   Eye                                     |    +                       +     +     +                 +           +   |             
      Cataract                             |                                                          1           1   |             
      Hemorrhage                           |    1                                                                     |             
      Cornea, Inflammation, Diffuse,       |                                                                          |             
          Subacute                         |                                                                          |             
      Cornea, Inflammation, Focal, Subacute|                                        3                                 |             
      Retina, Degeneration                 |    2                       2           2                 2           1   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  48                                                               
NTP Experiment-Test: 05048-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            RHODAMINE 6G                                       Date: 05/01/97  
Route: DOSED FEED                                                                                                 Time: 14:20:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 6| 7| 6| 6| 6| 7| 7| 6| 6| 6| 7| 7| 5| 6| 7| 7| 7| 6| 6| 7| 7| 7|             
                             DAY ON TEST   | 2| 4| 6| 9| 3| 6| 6| 9| 3| 3| 5| 6| 9| 3| 3| 2| 9| 2| 3| 3| 1| 9| 3| 3| 3|             
                                           | 0| 7| 8| 2| 4| 0| 3| 5| 5| 5| 4| 2| 6| 4| 5| 2| 2| 2| 5| 5| 9| 4| 5| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.012%                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bacterium                            |                                                                          |             
      Fibrosis, Focal                      |                         4                                                |             
      Inflammation, Acute, Suppurative     |                                                                          |             
      Inflammation, Chronic, Focal         |                         4                                                |             
      Nephropathy, Chronic                 | 2  2  3  3  3  2  2  2  4  3  3  3  3  4  3  1  4  2  3  3     4  3  3  3|             
      Pigmentation, Hemosiderin            |                         4                                                |             
      Cortex, Cyst                         |                         X                                                |             
      Cortex, Mineralization               |                                                                          |             
      Cortex, Necrosis, Focal              |    2                                                                     |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  49                                                               
NTP Experiment-Test: 05048-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            RHODAMINE 6G                                       Date: 05/01/97  
Route: DOSED FEED                                                                                                 Time: 14:20:05  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6| 6| 7| 7| 5| 6| 6| 7| 7| 5| 5| 7| 7| 7|            |
                             DAY ON TEST   | 4| 2| 3| 3| 3| 4| 2| 2| 3| 3| 2| 3| 4| 3| 3| 3| 4| 9| 0| 3| 5| 8| 3| 3| 3|            |
                                           | 6| 0| 5| 5| 5| 6| 8| 9| 3| 5| 0| 9| 7| 4| 5| 8| 3| 5| 8| 5| 9| 3| 5| 5| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      A     |
    0.012%                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  49        |
      Cecum, Parasite Metazoan             |                                                                          |      1  2.0|
      Colon, Parasite Metazoan             |                                           2                              |      5  2.0|
      Rectum, Mineralization               |                         2                                                |      1  2.0|
      Rectum, Parasite Metazoan            |       2                    2                                         2   |      4  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  49        |
      Peyer's Patch, Mineralization, Focal |                                                                          |      1  2.0|
      Peyer's Patch, Necrosis, Focal       |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis, Focal                   |                                           1           2           1  2  1|      6  1.7|
      Angiectasis, Multifocal              |                                     3                                    |      2  2.5|
      Basophilic Focus                     |                            X           X              X                  |      4     |
      Basophilic Focus, Multiple           |                      X                                                   |      1     |
      Congestion                           |                                                                          |      3  2.0|
      Developmental Malformation           |                                                                          |      1  2.0|
      Eosinophilic Focus                   |                                     X                                X   |      2     |
      Granuloma, Multifocal                |                      2     1                                             |      2  1.5|
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
      Hemorrhage, Multifocal               |                                                                          |      1  2.0|
      Hepatodiaphragmatic Nodule           |                                                                   X      |      1     |
      Necrosis, Multifocal                 |                                                 2                        |      1  2.0|
      Pigmentation, Hemosiderin, Multifocal|                                                                          |      1  2.0|
      Thrombosis                           |                                                             X            |      1     |
      Vacuolization Cytoplasmic, Diffuse   | 2                                            3                           |      3  2.7|
      Vacuolization Cytoplasmic, Focal     |                         2  2                                             |      3  2.3|
      Vacuolization Cytoplasmic, Multifocal|                                                       2                  |      1  2.0|
      Biliary Tract, Hyperplasia           | 2  3  2  2  2  3  4  2     1  2  3  3  3        1  3  2  2     2     2  1|     37  2.1|
      Centrilobular, Necrosis              | 1  1           1  1              1  1  1     1     1     1           1   |     19  1.4|
      Hepatocyte, Hypertrophy              |    2           2  1              2  1  1           1                     |      8  1.4|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                              +                           |   4        |
      Fat, Necrosis, Focal                 |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  49        |
      Atrophy                              |    3     2     4           2        3  2           2  2  1              1|     18  2.2|
      Acinus, Hyperplasia                  |                         3                                                |      1  3.0|
      Artery, Inflammation, Subacute       |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Artery, Inflammation, Subacute       |          2                                                               |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  50                                                               
NTP Experiment-Test: 05048-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            RHODAMINE 6G                                       Date: 05/01/97  
Route: DOSED FEED                                                                                                 Time: 14:20:05  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6| 6| 7| 7| 5| 6| 6| 7| 7| 5| 5| 7| 7| 7|            |
                             DAY ON TEST   | 4| 2| 3| 3| 3| 4| 2| 2| 3| 3| 2| 3| 4| 3| 3| 3| 4| 9| 0| 3| 5| 8| 3| 3| 3|            |
                                           | 6| 0| 5| 5| 5| 6| 8| 9| 3| 5| 0| 9| 7| 4| 5| 8| 3| 5| 8| 5| 9| 3| 5| 5| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      A     |
    0.012%                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Forestomach, Edema                   |                                                                          |      1  2.0|
      Forestomach, Hyperkeratosis          |                                                                2         |      2  2.0|
      Forestomach, Hyperplasia             |                                                                2         |      2  2.0|
      Forestomach, Inflammation, Subacute  |                                                                2         |      2  2.0|
      Forestomach, Mineralization          |                         3                       2                        |      2  2.5|
      Forestomach, Ulcer                   |                                                                3         |      1  3.0|
      Glandular, Edema                     |                                                                          |      1  2.0|
      Glandular, Erosion                   |                                                                          |      1  2.0|
      Glandular, Erosion, Multiple         |                                              4                           |      1  4.0|
      Glandular, Mineralization            |                         3                       4                        |      5  2.6|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                         +                       +                        |   2        |
      Mineralization                       |                         4                       3                        |      2  3.5|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Bacterium                            |                                                             4            |      1  4.0|
      Fibrosis, Multifocal                 | 1  2  2  2     1  1  2  2        2  1  1  2  2  2  2  2  1     2  1  2  2|     40  1.6|
      Inflammation, Acute, Suppurative     |                                                             4            |      1  4.0|
      Mineralization                       |                         2                       3                        |      2  2.5|
      Atrium, Thrombosis                   |       4                                                  2  4            |      3  3.3|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  49        |
      Hyperplasia, Focal                   |                                     2                                    |      1  2.0|
      Cortex, Degeneration, Fatty, Focal   |                                                    3                     |      5  1.8|
      Medulla, Hematopoietic Cell          |                                                                          |            |
          Proliferation                    |                                                                          |      1  2.0|
      Medulla, Hyperplasia, Focal          |    1  2  2        2  2  2           2              2                     |     10  1.9|
      Medulla, Hyperplasia, Multifocal     |                                           2                              |      1  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  49        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|  46        |
      Hyperplasia                          |                         2                       2                        |      4  1.8|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|  49        |
      Pars Distalis, Angiectasis           |                                                                         3|      5  2.0|
      Pars Distalis, Cyst                  |       X                                                                  |      1     |
      Pars Distalis, Hyperplasia, Focal    |                                                                   2      |      5  2.4|
      Pars Distalis, Pigmentation,         |                                                                          |            |
          Hemosiderin                      |                                                                          |      2  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  51                                                               
NTP Experiment-Test: 05048-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            RHODAMINE 6G                                       Date: 05/01/97  
Route: DOSED FEED                                                                                                 Time: 14:20:05  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6| 6| 7| 7| 5| 6| 6| 7| 7| 5| 5| 7| 7| 7|            |
                             DAY ON TEST   | 4| 2| 3| 3| 3| 4| 2| 2| 3| 3| 2| 3| 4| 3| 3| 3| 4| 9| 0| 3| 5| 8| 3| 3| 3|            |
                                           | 6| 0| 5| 5| 5| 6| 8| 9| 3| 5| 0| 9| 7| 4| 5| 8| 3| 5| 8| 5| 9| 3| 5| 5| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      A     |
    0.012%                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|  48        |
      Ultimobranchial Cyst                 |                                                                          |      2     |
      C-Cell, Hyperplasia, Focal           |                                                                          |      2  2.0|
      Follicle, Cyst                       |             X                                                            |      1     |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Inflammation, Acute, Suppurative     |             1                                2           3  3            |      8  2.4|
      Inflammation, Chronic                |                2                                                         |      1  2.0|
      Duct, Cyst                           |             X                                            X               |      6     |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Concretion                           |                                                                          |      1  2.0|
      Fibrosis                             |                                                                          |      1  4.0|
      Inflammation, Acute, Suppurative     | 2     2  1  2        2        3  2        2        1  2                 1|     16  1.9|
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Inflammation, Subacute               |                                     2           3        2               |      3  2.3|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |                +                             +                           |   4        |
      Inflammation, Chronic                |                2                                                         |      1  2.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                                                          |      2  2.5|
      Mineralization                       |                                                 2                        |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                              2                           |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|  49        |
      Deep Cervical, Congestion            |                                                 3                        |      1  3.0|
      Lumbar, Ectasia                      |                                        1                                 |      2  2.0|
      Mandibular, Ectasia                  |    2        2                       2  2  2        2     2               |      7  2.0|
      Mesenteric, Ectasia                  |    2           1                 1                                       |      5  1.4|
      Pancreatic, Ectasia                  |                                     2                                    |      1  2.0|
      Pancreatic, Hyperplasia              |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                            2                                             |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  52                                                               
NTP Experiment-Test: 05048-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            RHODAMINE 6G                                       Date: 05/01/97  
Route: DOSED FEED                                                                                                 Time: 14:20:05  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6| 6| 7| 7| 5| 6| 6| 7| 7| 5| 5| 7| 7| 7|            |
                             DAY ON TEST   | 4| 2| 3| 3| 3| 4| 2| 2| 3| 3| 2| 3| 4| 3| 3| 3| 4| 9| 0| 3| 5| 8| 3| 3| 3|            |
                                           | 6| 0| 5| 5| 5| 6| 8| 9| 3| 5| 0| 9| 7| 4| 5| 8| 3| 5| 8| 5| 9| 3| 5| 5| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      A     |
    0.012%                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Fibrosis                             |    2                    2                          2                     |      7  2.3|
      Hematopoietic Cell Proliferation     |                                              3                           |      4  2.5|
      Inflammation, Acute, Suppurative     |                                                             3            |      1  3.0|
      Necrosis, Focal                      |                                  4                                       |      1  4.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Cyst                                 |                                                       X                  |      1     |
      Mediastinum, Inflammation, Acute,    |                                                                          |            |
           Suppurative                     |                                                             4            |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|  49        |
      Duct, Cyst                           |    X  X        X  X                                            X  X     X|     18     |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst Epithelial Inclusion            |                                        X                          X      |      2     |
      Hyperkeratosis, Focal                |                            2                                             |      1  2.0|
      Hyperplasia, Focal                   |                            2                                             |      1  2.0|
      Hyperplasia                          |                                                                          |      1  3.0|
      Inflammation, Acute, Focal,          |                                                                          |            |
          Suppurative                      |                                                                          |      2  3.0|
      Inflammation, Chronic, Focal         |                                                                   2      |      1  2.0|
      Inflammation, Focal, Subacute        |                            2                                             |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrous Osteodystrophy               |                         X                       3                        |      3  3.0|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |             +                                +                           |   2        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression                          |                                                             X            |      1     |
      Degeneration, Multifocal             |                      2                                2                  |      4  1.8|
      Hemorrhage, Multifocal               |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                         2                       2                        |      3  2.0|
      Hemorrhage, Multifocal               |                   2                                                      |      1  2.0|
      Hyperplasia, Histiocytic             |                         2                                                |      1  2.0|
      Inflammation, Multifocal, Subacute   |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  53                                                               
NTP Experiment-Test: 05048-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            RHODAMINE 6G                                       Date: 05/01/97  
Route: DOSED FEED                                                                                                 Time: 14:20:05  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6| 6| 7| 7| 5| 6| 6| 7| 7| 5| 5| 7| 7| 7|            |
                             DAY ON TEST   | 4| 2| 3| 3| 3| 4| 2| 2| 3| 3| 2| 3| 4| 3| 3| 3| 4| 9| 0| 3| 5| 8| 3| 3| 3|            |
                                           | 6| 0| 5| 5| 5| 6| 8| 9| 3| 5| 0| 9| 7| 4| 5| 8| 3| 5| 8| 5| 9| 3| 5| 5| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      A     |
    0.012%                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Mineralization                       |                                                 2                        |      1  2.0|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |                                                       2                  |      2  2.5|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Foreign Body                         |                            2              2              2              2|      8  2.1|
      Fungus                               |                3           3     3  3  3  3     3        3        3     3|     20  3.0|
      Inflammation, Acute, Suppurative     |                2           1     2  2  1  3     2        2        2     2|     20  1.8|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Acute, Suppurative              |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                         +                 +              +              +|   8        |
                                            __________________________________________________________________________|____________|
   Eye                                     |                         +                                      +         |   8        |
      Cataract                             |                                                                3         |      3  1.7|
      Hemorrhage                           |                                                                          |      1  1.0|
      Cornea, Inflammation, Diffuse,       |                                                                          |            |
          Subacute                         |                         2                                                |      1  2.0|
      Cornea, Inflammation, Focal, Subacute|                                                                          |      1  3.0|
      Retina, Degeneration                 |                                                                3         |      6  2.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Bacterium                            |                                                             3            |      1  3.0|
      Fibrosis, Focal                      |                                                                          |      1  4.0|
      Inflammation, Acute, Suppurative     |                                                             3            |      1  3.0|
      Inflammation, Chronic, Focal         |                                                                          |      1  4.0|
      Nephropathy, Chronic                 | 2  2  3  3  2  2  2  3  4  2  2  2  3  2  4  1  4  3  2  3     3  3  4  2|     48  2.7|
      Pigmentation, Hemosiderin            |                                                                          |      1  4.0|
      Cortex, Cyst                         |                                                    X                     |      2     |
      Cortex, Mineralization               |                         3                       4                        |      2  3.5|
      Cortex, Necrosis, Focal              |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  49        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  54                                                               
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