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TR 365 Mouse Pathology Tables


                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                    PENTAERYTHRITOL TETRANITRATE


NTP Experiment-Test: 05023-02                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 09/04/94
Route: DOSED FEED                                                                                                 Time: 02:05:43




       Facility:  TSI Mason Research

       Chemical CAS #:  78-11-5

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05023-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                    PENTAERYTHRITOL TETRANITRATE                               Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 02:05:43  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTROL      2.5%         5.0%                                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Dead                                               7           12            7                                                  
    Moribund                                           5            8            5                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                38           30           38                                                  
  Animals Examined Microscopically                    50           50           50                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (46)         (41)         (43)                                                
   Intestine Large, Colon                             (49)         (11)         (49)                                                
   Intestine Small, Ileum                             (47)         (11)         (46)                                                
   Intestine Small, Jejunum                           (46)         (11)         (44)                                                
   Liver                                              (49)         (50)         (49)                                                
      Hemangiosarcoma                                  1 (2%)       2 (4%)                                                          
      Hepatocellular Carcinoma                         1 (2%)                                                                       
      Hepatocellular Adenoma                           5 (10%)      2 (4%)       1 (2%)                                             
      Histiocytic Sarcoma, Metastatic, Uterus                                    1 (2%)                                             
      Sarcoma, Metastatic, Uncertain Primary Site                                1 (2%)                                             
   Mesentery                                                       (6)          (1)                                                 
      Sarcoma, Metastatic, Uncertain Primary Site                                1 (100%)                                           
   Pancreas                                           (49)         (13)         (49)                                                
      Histiocytic Sarcoma, Metastatic, Uterus                                    1 (2%)                                             
      Sarcoma, Metastatic, Uncertain Primary Site                                1 (2%)                                             
   Salivary Glands                                    (49)         (12)         (48)                                                
   Stomach, Forestomach                               (49)         (50)         (49)                                                
      Squamous Cell Papilloma                          1 (2%)                    1 (2%)                                             
   Stomach, Glandular                                 (47)         (49)         (48)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (12)         (49)                                                
      Adenocarcinoma, Metastatic, Uterus               1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (49)         (12)         (49)                                                
   Adrenal Gland, Cortex                              (48)         (12)         (49)                                                
      Sarcoma, Metastatic, Uncertain Primary Site                                1 (2%)                                             
   Adrenal Gland, Medulla                             (47)         (11)         (47)                                                
                                                             Page   2                                                               
NTP Experiment-Test: 05023-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                    PENTAERYTHRITOL TETRANITRATE                               Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 02:05:43  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTROL      2.5%         5.0%                                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - cont                                                                                                             
      Pheochromocytoma Benign                          1 (2%)                                                                       
   Islets, Pancreatic                                 (49)         (12)         (48)                                                
      Adenoma                                                                    1 (2%)                                             
   Pituitary Gland                                    (45)         (15)         (42)                                                
      Pars Distalis, Adenoma                           8 (18%)      3 (20%)      5 (12%)                                            
      Pars Distalis, Carcinoma                         1 (2%)                                                                       
      Pars Intermedia, Adenoma                                      1 (7%)                                                          
   Thyroid Gland                                      (47)         (12)         (47)                                                
      Follicular Cell, Adenoma                         1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (50)         (19)         (48)                                                
      Adenocarcinoma, Metastatic, Uterus               1 (2%)                                                                       
      Choriocarcinoma                                               1 (5%)                                                          
      Cystadenoma                                      1 (2%)                    2 (4%)                                             
      Granulosa Cell Tumor Benign                      2 (4%)       1 (5%)                                                          
      Luteoma                                                                    1 (2%)                                             
      Sarcoma, Metastatic, Uncertain Primary Site                                1 (2%)                                             
      Teratoma                                                                   1 (2%)                                             
      Teratoma Malignant                               1 (2%)                                                                       
   Uterus                                             (49)         (37)         (49)                                                
      Adenocarcinoma                                   1 (2%)                                                                       
      Histiocytic Sarcoma                                                        1 (2%)                                             
      Leiomyoma                                                     1 (3%)                                                          
      Polyp Stromal                                    3 (6%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (49)         (12)         (49)                                                
   Lymph Node                                         (50)         (17)         (48)                                                
   Lymph Node, Mandibular                             (40)         (8)          (42)                                                
   Lymph Node, Mesenteric                             (48)         (12)         (46)                                                
      Sarcoma, Metastatic, Uncertain Primary Site                                1 (2%)                                             
   Spleen                                             (50)         (50)         (50)                                                
      Hemangiosarcoma                                                            1 (2%)                                             
      Sarcoma, Metastatic, Uncertain Primary Site                                1 (2%)                                             
   Thymus                                             (42)         (10)         (40)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   3                                                               
NTP Experiment-Test: 05023-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                    PENTAERYTHRITOL TETRANITRATE                               Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 02:05:43  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTROL      2.5%         5.0%                                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (39)         (5)          (34)                                                
      Adenoacanthoma                                                1 (20%)                                                         
      Adenocarcinoma                                   1 (3%)       2 (40%)      1 (3%)                                             
   Skin                                               (49)         (13)         (46)                                                
      Subcutaneous Tissue, Fibrosarcoma                             2 (15%)      1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                    (1)          (2)          (1)                                                 
      Diaphragm, Sarcoma, Metastatic, Uncertain                                                                                     
          Primary Site                                                           1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (12)         (49)                                                
      Carcinoma, Metastatic, Pituitary Gland           1 (2%)                                                                       
   Spinal Cord                                        (1)          (1)                                                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (16)         (49)                                                
      Adenocarcinoma, Metastatic, Uterus               1 (2%)                                                                       
      Alveolar/Bronchiolar Adenoma                     2 (4%)       2 (13%)      4 (8%)                                             
      Alveolar/Bronchiolar Carcinoma                   1 (2%)       1 (6%)                                                          
      Carcinoma, Metastatic, Harderian Gland           1 (2%)                                                                       
      Alveolar Epithelium, Alveolar/Bronchiolar                                                                                     
          Adenoma                                                                1 (2%)                                             
      Pleura, Sarcoma, Metastatic, Uncertain                                                                                        
          Primary Site                                                           1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (3)          (2)          (7)                                                 
      Adenoma                                          2 (67%)      2 (100%)     5 (71%)                                            
      Carcinoma                                        1 (33%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   4                                                               
NTP Experiment-Test: 05023-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                    PENTAERYTHRITOL TETRANITRATE                               Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 02:05:43  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTROL      2.5%         5.0%                                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (14)         (49)                                                
      Histiocytic Sarcoma, Metastatic, Uterus                                    1 (2%)                                             
   Urinary Bladder                                    (47)         (11)         (48)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)                                                
      Histiocytic Sarcoma                                                        1 (2%)                                             
      Lymphoma Malignant                                            2 (4%)       1 (2%)                                             
      Lymphoma Malignant Histiocytic                   3 (6%)       3 (6%)                                                          
      Lymphoma Malignant Lymphocytic                   1 (2%)       1 (2%)                                                          
      Lymphoma Malignant Mixed                        10 (20%)     10 (20%)     10 (20%)                                            
      Lymphoma Malignant Undifferentiated Cell         6 (12%)      1 (2%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   5                                                               
NTP Experiment-Test: 05023-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                    PENTAERYTHRITOL TETRANITRATE                               Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 02:05:43  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTROL      2.5%         5.0%                                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            37          29          28                                                   
     Total Primary Neoplasms                           54          38          38                                                   
                                                                                                                                    
   Total Animals with Benign Neoplasms                 18          12          18                                                   
     Total Benign Neoplasms                            26          12          22                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms              28          22          16                                                   
     Total Malignant Neoplasms                         28          26          16                                                   
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              3                       2                                                   
     Total Metastatic Neoplasm                          5                      12                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                       1                                                   
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   6                                                               
NTP Experiment-Test: 05023-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                    PENTAERYTHRITOL TETRANITRATE                               Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 02:05:43  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      2.5%         5.0%                                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Moribund                                          15            6            9                                                  
    Dead                                               8            6            3                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                26           38           38                                                  
  Wrong Sex                                            1                                                                            
  Animals Examined Microscopically                    49           50           50                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (47)         (7)          (47)                                                
   Intestine Small, Ileum                             (44)         (6)          (47)                                                
   Intestine Small, Jejunum                           (44)         (7)          (47)                                                
   Liver                                              (48)         (24)         (49)                                                
      Fibrosarcoma, Metastatic, Skin                   1 (2%)                                                                       
      Hemangiosarcoma                                  1 (2%)       2 (8%)                                                          
      Hepatocellular Carcinoma                         3 (6%)       4 (17%)      5 (10%)                                            
      Hepatocellular Adenoma                           8 (17%)      6 (25%)      7 (14%)                                            
      Hepatocellular Adenoma, Multiple                 1 (2%)       1 (4%)                                                          
      Ito Cell Tumor Benign                            1 (2%)                                                                       
      Squamous Cell Carcinoma, Metastatic, Stomach                  1 (4%)                                                          
   Salivary Glands                                    (46)         (9)          (47)                                                
   Stomach, Forestomach                               (47)         (49)         (46)                                                
      Squamous Cell Carcinoma                                       1 (2%)                                                          
      Squamous Cell Papilloma                                       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (48)         (9)          (50)                                                
      Carcinoma, Metastatic, Lung                                   1 (11%)                                                         
      Fibrosarcoma, Metastatic, Skin                   1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (46)         (13)         (48)                                                
      Adenoma                                                                    1 (2%)                                             
   Adrenal Gland, Medulla                             (45)         (13)         (47)                                                
      Pheochromocytoma Benign                          1 (2%)       1 (8%)       1 (2%)                                             
   Pituitary Gland                                    (45)         (8)          (48)                                                
      Pars Distalis, Adenoma                                                     1 (2%)                                             
                                                             Page   7                                                               
NTP Experiment-Test: 05023-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                    PENTAERYTHRITOL TETRANITRATE                               Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 02:05:43  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      2.5%         5.0%                                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - cont                                                                                                             
   Thyroid Gland                                      (46)         (8)          (46)                                                
      Follicular Cell, Adenoma                         1 (2%)                    1 (2%)                                             
      Follicular Cell, Carcinoma                       1 (2%)                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (48)         (9)          (49)                                                
   Prostate                                           (43)         (8)          (48)                                                
   Testes                                             (48)         (9)          (49)                                                
      Interstitial Cell, Adenoma                                    1 (11%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node                                         (46)         (23)         (47)                                                
      Mediastinal, Carcinoma, Metastatic, Lung                      1 (4%)                                                          
   Lymph Node, Mandibular                             (25)         (3)          (28)                                                
      Pancreatic, Hemangiosarcoma, Metastatic          1 (4%)                                                                       
   Lymph Node, Mesenteric                             (44)         (22)         (45)                                                
      Hemangioma                                                    1 (5%)       1 (2%)                                             
   Spleen                                             (47)         (26)         (47)                                                
      Fibrosarcoma, Metastatic, Skin                   1 (2%)                                                                       
      Hemangiosarcoma                                               2 (8%)                                                          
   Thymus                                             (36)         (7)          (42)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (48)         (22)         (47)                                                
      Basal Cell Adenoma                               1 (2%)                                                                       
      Squamous Cell Papilloma                                                    1 (2%)                                             
      Subcutaneous Tissue, Fibroma                     1 (2%)       2 (9%)       1 (2%)                                             
      Subcutaneous Tissue, Fibroma, Multiple           4 (8%)                                                                       
      Subcutaneous Tissue, Fibrosarcoma               12 (25%)      2 (9%)       5 (11%)                                            
      Subcutaneous Tissue, Fibrosarcoma, Multiple      2 (4%)                    3 (6%)                                             
      Subcutaneous Tissue, Hemangiosarcoma             1 (2%)       1 (5%)       1 (2%)                                             
      Subcutaneous Tissue, Neurofibrosarcoma,                                                                                       
          Multiple                                                  1 (5%)                                                          
      Subcutaneous Tissue, Sarcoma                     2 (4%)       2 (9%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   8                                                               
NTP Experiment-Test: 05023-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                    PENTAERYTHRITOL TETRANITRATE                               Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 02:05:43  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      2.5%         5.0%                                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (48)         (31)         (50)                                                
      Mandible, Osteosarcoma                                                     1 (2%)                                             
      Synovial Tissue, Sarcoma                                      1 (3%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (47)         (17)         (50)                                                
      Alveolar/Bronchiolar Adenoma                     9 (19%)      5 (29%)      1 (2%)                                             
      Alveolar/Bronchiolar Adenoma, Multiple           2 (4%)                    2 (4%)                                             
      Alveolar/Bronchiolar Carcinoma                   1 (2%)       3 (18%)      5 (10%)                                            
      Carcinoma                                                     1 (6%)                                                          
      Fibrosarcoma, Metastatic, Skin                   1 (2%)                                                                       
      Mediastinum, Carcinoma, Metastatic, Lung                      1 (6%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (1)          (3)          (5)                                                 
      Adenoma                                          1 (100%)     2 (67%)      3 (60%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (47)         (13)         (49)                                                
      Renal Tubule, Adenoma                                         1 (8%)                                                          
   Urinary Bladder                                    (45)         (15)         (47)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(49)        *(50)        *(50)                                                
      Lymphoma Malignant Histiocytic                                1 (2%)       1 (2%)                                             
      Lymphoma Malignant Lymphocytic                                2 (4%)                                                          
      Lymphoma Malignant Mixed                         4 (8%)       2 (4%)       3 (6%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   9                                                               
NTP Experiment-Test: 05023-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                    PENTAERYTHRITOL TETRANITRATE                               Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 02:05:43  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      2.5%         5.0%                                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            36          28          32                                                   
     Total Primary Neoplasms                           57          46          45                                                   
                                                                                                                                    
   Total Animals with Benign Neoplasms                 25          16          19                                                   
     Total Benign Neoplasms                            30          21          20                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms              21          21          20                                                   
     Total Malignant Neoplasms                         27          25          25                                                   
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              2           2                                                               
     Total Metastatic Neoplasm                          5           4                                                               
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  10                                                               
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