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TR 365 Mouse Pathology Tables

NTP Experiment-Test: 05023-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                    PENTAERYTHRITOL TETRANITRATE                               Date: 05/01/97
Route: DOSED FEED                                                                                                 Time: 13:22:26




       Facility:  TSI Mason Research

       Chemical CAS #:  78-11-5

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All






































                                                              Page   1

NTP Experiment-Test: 05023-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                    PENTAERYTHRITOL TETRANITRATE                               Date: 05/01/97  
Route: DOSED FEED                                                                                                 Time: 13:22:26  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9|             
                                           | 3| 2| 2| 2| 2| 3| 2| 2| 2| 2| 2| 2| 2| 2| 6| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Epithelium, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Lymphoid Nodule, Mineralization      |                                                          1               |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                                                          |             
      Clear Cell Focus                     |                                                                          |             
      Fatty Change, Diffuse                |                                                                          |             
      Fatty Change, Focal                  |                                                                          |             
      Fibrosis                             |       2                                                                  |             
      Mineralization                       |                                                                          |             
      Necrosis                             |       1        1                                                        2|             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Acinus, Atrophy                      |                            2                 1                           |             
      Acinus, Hypertrophy                  |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                                                   2      |             
      Hyperkeratosis                       |                                                       2  1  2     2      |             
      Inflammation, Chronic Active         |                                                             1            |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |             1                                            1               |             
      Mineralization                       |                                                                         1|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                                                          |             
      Thrombosis                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Capsule, Hyperplasia                 | 2  1  2  2     2  2  2  2  2  2  2  1  1     2     1  2  1  2  2  1  1  2|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05023-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                    PENTAERYTHRITOL TETRANITRATE                               Date: 05/01/97  
Route: DOSED FEED                                                                                                 Time: 13:22:26  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9|             
                                           | 3| 2| 2| 2| 2| 3| 2| 2| 2| 2| 2| 2| 2| 2| 6| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia                          | 2  1  2  2     2  2  2  2     2  2  1  1     2     1  2  1  2     1     2|             
      Hypertrophy                          |                1                                                     1   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                           2                              |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  M  +  M  +  M  +  +  M  M  +  +  +  M  M  +  +  +  +  +  M  M  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Pars Distalis, Angiectasis           |                                                    1                     |             
      Pars Distalis, Hyperplasia           |                         1        1                                       |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Hyperplasia         |    1                                                                     |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |    X        X                 X                             X            |             
      Degeneration, Cystic                 |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Papillary               |                                                                          |             
                                            __________________________________________________________________________|             
   Oviduct                                 |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                          1               |             
      Inflammation, Chronic Active         |       3  2                                                               |             
      Endometrium, Hyperplasia             | 2  1  1  1  2  2  2  2  2     2  2  2  2     2  3  3  2  2     2  2  2   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Myelofibrosis                        |                            2                                   2     2   |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lumbar, Angiectasis                  |                                                                          |             
      Mediastinal, Angiectasis             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                         1|             
      Hematopoietic Cell Proliferation     |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                 1                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05023-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                    PENTAERYTHRITOL TETRANITRATE                               Date: 05/01/97  
Route: DOSED FEED                                                                                                 Time: 13:22:26  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9|             
                                           | 3| 2| 2| 2| 2| 3| 2| 2| 2| 2| 2| 2| 2| 2| 6| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hematopoietic Cell Proliferation     | 2  1  2  2  1  1  1  1  2     1  1  1              1  1  1           1   |             
      Lymphoid Follicle, Hyperplasia       |                2           3                                      2      |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Hyperplasia                  |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                            1                                   1     2   |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                             +            |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Edema                                |                                           1                              |             
      Hemorrhage                           |                                                       1  1               |             
      Infiltration Cellular, Histiocyte    |       1                                                                  |             
      Inflammation, Chronic Active         |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  M  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05023-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                    PENTAERYTHRITOL TETRANITRATE                               Date: 05/01/97  
Route: DOSED FEED                                                                                                 Time: 13:22:26  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 7| 7| 6| 6| 3| 7| 7| 7| 5| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6|            |
                             DAY ON TEST   | 3| 3| 3| 2| 9| 3| 3| 5| 3| 3| 3| 3| 3| 4| 2| 3| 3| 3| 3| 4| 3| 3| 3| 1| 8|            |
                                           | 2| 2| 3| 9| 4| 3| 2| 4| 7| 8| 2| 2| 2| 9| 2| 2| 2| 2| 2| 8| 2| 2| 3| 6| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      A     |
    CONTROL                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  A  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  M  +  +  M  M  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +|  45        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  M  +  A  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Epithelium, Hyperplasia              | 1                                                                        |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  A  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Lymphoid Nodule, Mineralization      |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|  46        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Basophilic Focus                     |                                                    X                     |      1     |
      Clear Cell Focus                     |                   X                                                      |      1     |
      Fatty Change, Diffuse                |                                        2                             2   |      2  2.0|
      Fatty Change, Focal                  |                                              1                           |      1  1.0|
      Fibrosis                             |                                                                          |      1  2.0|
      Mineralization                       |                         1                                                |      1  1.0|
      Necrosis                             |    1     3  3                                                            |      6  1.8|
      Pigmentation                         |                   1                                                      |      1  1.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Chronic Active         |                3                                2                        |      2  2.5|
      Acinus, Atrophy                      |                                                                          |      2  1.5|
      Acinus, Hypertrophy                  |                                     1                                    |      1  1.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Acanthosis                           |             2                                                            |      2  2.0|
      Hyperkeratosis                       |    1                       1        1                 1  2           2  1|     11  1.5|
      Inflammation, Chronic Active         |                                                                         1|      2  1.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  A  +  +  +  +  M  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Inflammation, Chronic Active         |                                     1                                    |      3  1.0|
      Mineralization                       |                                  1                                       |      2  1.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mineralization                       |             2                                                            |      1  2.0|
      Thrombosis                           |                                  X                                       |      1     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   5                                                               
NTP Experiment-Test: 05023-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                    PENTAERYTHRITOL TETRANITRATE                               Date: 05/01/97  
Route: DOSED FEED                                                                                                 Time: 13:22:26  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 7| 7| 6| 6| 3| 7| 7| 7| 5| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6|            |
                             DAY ON TEST   | 3| 3| 3| 2| 9| 3| 3| 5| 3| 3| 3| 3| 3| 4| 2| 3| 3| 3| 3| 4| 3| 3| 3| 1| 8|            |
                                           | 2| 2| 3| 9| 4| 3| 2| 4| 7| 8| 2| 2| 2| 9| 2| 2| 2| 2| 2| 8| 2| 2| 3| 6| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      A     |
    CONTROL                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Capsule, Hyperplasia                 | 2  2  1     1  1  2     2     2  2  2        1  2  2  1     2  2  2     1|     40  1.7|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|  48        |
      Hematopoietic Cell Proliferation     |                         2                                                |      1  2.0|
      Hyperplasia                          | 2  2  1     1     2     2     2  2  2        1     2  1  2  2  2  2     1|     36  1.7|
      Hypertrophy                          |                                                       1                  |      3  1.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Hyperplasia                          |                                                          2               |      1  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  M  +  A  M  +  +  +  +  +  +  +  M  +  M  +  +  +  M  +  M  M  +  +  +|  32        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  M  +|  45        |
      Pars Distalis, Angiectasis           |                1  1                    2                                 |      4  1.3|
      Pars Distalis, Hyperplasia           |                   1                          1        2     1  2        1|      8  1.3|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|  47        |
      Follicular Cell, Hyperplasia         |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |                      M                                                   |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |    X                             X  X     X                 X            |      9     |
      Degeneration, Cystic                 |                      2                                                   |      1  2.0|
      Hemorrhage                           |                            2                                             |      1  2.0|
      Hyperplasia, Papillary               |                               1                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Oviduct                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +|  49        |
      Angiectasis                          | 2                                                                        |      2  1.5|
      Inflammation, Chronic Active         |                                              2                           |      3  2.3|
      Endometrium, Hyperplasia             | 2  1  2     2  1              2     2     2  2  2     1     2     2  2  1|     36  1.9|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Myelofibrosis                        |                2                                1                        |      5  1.8|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   6                                                               
NTP Experiment-Test: 05023-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                    PENTAERYTHRITOL TETRANITRATE                               Date: 05/01/97  
Route: DOSED FEED                                                                                                 Time: 13:22:26  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 7| 7| 6| 6| 3| 7| 7| 7| 5| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6|            |
                             DAY ON TEST   | 3| 3| 3| 2| 9| 3| 3| 5| 3| 3| 3| 3| 3| 4| 2| 3| 3| 3| 3| 4| 3| 3| 3| 1| 8|            |
                                           | 2| 2| 3| 9| 4| 3| 2| 4| 7| 8| 2| 2| 2| 9| 2| 2| 2| 2| 2| 8| 2| 2| 3| 6| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      A     |
    CONTROL                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Lumbar, Angiectasis                  | 3                                                                        |      1  3.0|
      Mediastinal, Angiectasis             |       3                                                                  |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  M  M  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +|  40        |
      Hematopoietic Cell Proliferation     |                         2                                         1      |      2  1.5|
      Hyperplasia, Lymphoid                |                                                    2                     |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|  48        |
      Angiectasis                          |          1              2                                                |      3  1.3|
      Hematopoietic Cell Proliferation     |                         3                                                |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                                          |      1  1.0|
      Hematopoietic Cell Proliferation     |    1  1        1  2     3  2  1  1  1        2  2  1  1  2  2  1  1  1  1|     35  1.3|
      Lymphoid Follicle, Hyperplasia       |                                  2                                       |      4  2.3|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  A  M  +  +  M  M  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +|  42        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  M  M  +  M  M  +  M  M  M  M  +  M  +  +  +  M  +|  39        |
      Acinus, Hyperplasia                  |                                        2                                 |      1  2.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                          +               |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mineralization                       |                2                                1                        |      5  1.4|
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                                                 2                        |      1  2.0|
      Edema                                |                            2                                             |      2  1.5|
      Hemorrhage                           |                      1           2              1                    1   |      6  1.2|
      Infiltration Cellular, Histiocyte    |                                  2                             1         |      3  1.3|
      Inflammation, Chronic Active         |                                     2                                    |      1  2.0|
      Alveolar Epithelium, Hyperplasia     |                                     2                                    |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +|  43        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   7                                                               
NTP Experiment-Test: 05023-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                    PENTAERYTHRITOL TETRANITRATE                               Date: 05/01/97  
Route: DOSED FEED                                                                                                 Time: 13:22:26  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 7| 7| 6| 6| 3| 7| 7| 7| 5| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6|            |
                             DAY ON TEST   | 3| 3| 3| 2| 9| 3| 3| 5| 3| 3| 3| 3| 3| 4| 2| 3| 3| 3| 3| 4| 3| 3| 3| 1| 8|            |
                                           | 2| 2| 3| 9| 4| 3| 2| 4| 7| 8| 2| 2| 2| 9| 2| 2| 2| 2| 2| 8| 2| 2| 3| 6| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      A     |
    CONTROL                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |    +                          +                                          |   2        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |    +           +              +                                          |   3        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|  47        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   8                                                               
NTP Experiment-Test: 05023-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                    PENTAERYTHRITOL TETRANITRATE                               Date: 05/01/97  
Route: DOSED FEED                                                                                                 Time: 13:22:26  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 0| 7| 7| 7| 4| 7| 7| 7| 6| 5| 7| 7| 7| 7| 6| 7| 7| 7| 6| 5|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 0| 3| 3| 3| 2| 3| 3| 3| 8| 7| 3| 3| 3| 3| 7| 3| 3| 1| 6| 8|             
                                           | 1| 1| 1| 1| 0| 5| 1| 1| 1| 1| 1| 1| 1| 8| 9| 1| 1| 1| 1| 4| 1| 1| 8| 2| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    2.5%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |             +  M           +              +              +           +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         |             +  +           +              +                          +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |             +  A           +              +                          +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |             +  +           +              +                          +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |             +  A           +              +                          +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +           +  +           +              +                 +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +           +  +           M              +                          +  +|             
      Lymphoid Nodule, Hyperplasia         |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +           +  A           +              +                          +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +           +  A           A              +                 +  +     +  +|             
      Hyperplasia                          | 2                                                                        |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                  X                                       |             
      Clear Cell Focus                     |       X                                                                  |             
      Fatty Change, Diffuse                |                                     1                                    |             
      Fatty Change, Focal                  |             1                                                  1         |             
      Hematopoietic Cell Proliferation     |                            2  2        3  2              2               |             
      Hemorrhage                           |                                                                          |             
      Necrosis                             | 1                             2                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                            +              +                              |             
      Inflammation, Acute                  |                            2              3                              |             
      Fat, Necrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |             +  +           +              +                          +  +|             
      Cyst                                 |                                                                          |             
      Acinus, Atrophy                      |                                                                      1   |             
      Duct, Dilatation                     |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |             +  +           +              +                       +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |          2                             2                                 |             
      Hyperkeratosis                       |          2              2           1  2                                 |             
      Necrosis                             |                                        2                                 |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Inflammation, Chronic Active         |                               1                                          |             
      Mineralization                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |             +  +           +              +                          +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |             +  +           +              +                          +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   9                                                               
NTP Experiment-Test: 05023-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                    PENTAERYTHRITOL TETRANITRATE                               Date: 05/01/97  
Route: DOSED FEED                                                                                                 Time: 13:22:26  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 0| 7| 7| 7| 4| 7| 7| 7| 6| 5| 7| 7| 7| 7| 6| 7| 7| 7| 6| 5|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 0| 3| 3| 3| 2| 3| 3| 3| 8| 7| 3| 3| 3| 3| 7| 3| 3| 1| 6| 8|             
                                           | 1| 1| 1| 1| 0| 5| 1| 1| 1| 1| 1| 1| 1| 8| 9| 1| 1| 1| 1| 4| 1| 1| 8| 2| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    2.5%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Capsule, Hyperplasia                 |             2              2              2                          2  2|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |             +  +           +              +                          +  +|             
      Hyperplasia                          |             2              2              2                          2  2|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |             +  +           +              +                          +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |             +  +           +              +                          +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |             +  +           +              +                          +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |             +  +           +        +     +  +                       +  +|             
      Pars Distalis, Angiectasis           |                                     2                                    |             
      Pars Distalis, Hyperplasia           |                                                                         1|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |             +  +           +              +                          +  +|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +           +  +  +        +           +  +        +                 +  +|             
      Abscess                              |                                        4  4                              |             
      Cyst                                 |                                                    X                     |             
      Degeneration, Cystic                 | 2                 4                       3        3                    3|             
      Hemorrhage                           |                3                                                         |             
      Bilateral, Abscess                   |                            4                                             |             
                                            __________________________________________________________________________|             
   Oviduct                                 |             +                                                        +   |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +|             
      Abscess                              |                               3                                          |             
      Angiectasis                          |                      2                                                   |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Chronic Active         |                                        2                    1            |             
      Pigmentation                         |                                                                          |             
      Endometrium, Hyperplasia             |    2  3           3  2           3  3  2        3  3  3  2  2     3      |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |             +  +           +              +                          +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |             +  +           +           +  +              +        +  +  +|             
      Axillary, Hematopoietic Cell         |                                                                          |             
          Proliferation                    |                                           1                              |             
      Axillary, Infiltration Cellular,     |                                                                          |             
           Plasma Cell                     |                                           2                              |             
      Lumbar, Hematopoietic Cell           |                                                                          |             
          Proliferation                    |                                           2                              |             
      Lumbar, Infiltration Cellular,       |                                                                          |             
          Plasma Cell                      |                                           2                              |             
      Mediastinal, Infiltration Cellular,  |                                                                          |             
           Plasma Cell                     |                            2              3                              |             
      Renal, Hematopoietic Cell            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  10                                                               
NTP Experiment-Test: 05023-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                    PENTAERYTHRITOL TETRANITRATE                               Date: 05/01/97  
Route: DOSED FEED                                                                                                 Time: 13:22:26  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 0| 7| 7| 7| 4| 7| 7| 7| 6| 5| 7| 7| 7| 7| 6| 7| 7| 7| 6| 5|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 0| 3| 3| 3| 2| 3| 3| 3| 8| 7| 3| 3| 3| 3| 7| 3| 3| 1| 6| 8|             
                                           | 1| 1| 1| 1| 0| 5| 1| 1| 1| 1| 1| 1| 1| 8| 9| 1| 1| 1| 1| 4| 1| 1| 8| 2| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    2.5%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
          Proliferation                    |                                           2                              |             
      Renal, Infiltration Cellular, Plasma |                                                                          |             
          Cell                             |                                           2                              |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |             +  +           M              +                       +  +  +|             
      Hematopoietic Cell Proliferation     |                                           2                             2|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |             +  M           M           +  +                          +  +|             
      Angiectasis                          |             2                                                            |             
      Hematopoietic Cell Proliferation     |                                        2  1                              |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |          2  2        2     3  3     1  3  3  2              2     2  2  3|             
      Lymphoid Follicle, Hyperplasia       |    2                                3                                    |             
                                            __________________________________________________________________________|             
   Thymus                                  |             +  +           M              +                          +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |             +  M           M              +                          M  +|             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    |             +  +           +  +           +                          +  +|             
      Necrosis                             |                               3                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |             +  +           +              +                          +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |             +  +           +              +                          +  +|             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                   +      |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |             +  +           +  +           +              +           +  +|             
      Hemorrhage                           |                                           1                              |             
      Infiltration Cellular, Histiocyte    |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |             +  +           +              +                          +  +|             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Acute                           |             3                                                            |             
                                            __________________________________________________________________________|             
   Trachea                                 |             +  +           +  +           +              +           +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     | +                                +                                       |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                  +                                       |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |             +  +           +              +                          +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  11                                                               
NTP Experiment-Test: 05023-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                    PENTAERYTHRITOL TETRANITRATE                               Date: 05/01/97  
Route: DOSED FEED                                                                                                 Time: 13:22:26  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 0| 7| 7| 7| 4| 7| 7| 7| 6| 5| 7| 7| 7| 7| 6| 7| 7| 7| 6| 5|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 0| 3| 3| 3| 2| 3| 3| 3| 8| 7| 3| 3| 3| 3| 7| 3| 3| 1| 6| 8|             
                                           | 1| 1| 1| 1| 0| 5| 1| 1| 1| 1| 1| 1| 1| 8| 9| 1| 1| 1| 1| 4| 1| 1| 8| 2| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    2.5%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Papilla, Mineralization              |                            1                                             |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |             +  +           +              +                          +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  12                                                               
NTP Experiment-Test: 05023-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                    PENTAERYTHRITOL TETRANITRATE                               Date: 05/01/97  
Route: DOSED FEED                                                                                                 Time: 13:22:26  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 5| 5| 7| 7| 7| 7| 7| 7| 7| 6| 6| 5| 7| 7| 7| 7| 6| 7| 7| 7| 6| 5|            |
                             DAY ON TEST   | 3| 3| 1| 6| 2| 3| 3| 3| 3| 3| 3| 3| 9| 3| 6| 3| 3| 3| 2| 7| 3| 3| 2| 7| 2|            |
                                           | 1| 1| 4| 8| 1| 1| 1| 1| 1| 1| 2| 2| 6| 4| 8| 2| 2| 2| 8| 4| 2| 2| 8| 0| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|      A     |
    2.5%                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |          +  +                          +  +                          +  +|  12        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  A  A  A  +  +  +  +  +  +  +  +  +  A  +  +  +  A  +  +  +     A  +|  41        |
      Inflammation, Acute                  |                   1                                                      |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Large                         |          A  +                          +  +                          +  +|  11        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |          A  +                          +  +                          +  +|  10        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |          A  +                          +  +                          +  +|  11        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |          A  +                          M  +                          +  +|   9        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |    +     +  +                          +  +                          A  +|  15        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |    +     A  +                          +  +                          A  +|  11        |
      Lymphoid Nodule, Hyperplasia         |    2                                                                     |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |          +  +                          +  +                          A  +|  11        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |    +     A  +                          A  +                          A  +|  11        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     |                                                                          |      1     |
      Clear Cell Focus                     |                      X                                      X            |      3     |
      Fatty Change, Diffuse                |                                                                          |      1  1.0|
      Fatty Change, Focal                  |       2                 1                                            2   |      5  1.4|
      Hematopoietic Cell Proliferation     |                                                          3               |      6  2.3|
      Hemorrhage                           |                                              2                           |      1  2.0|
      Necrosis                             |                            1                                             |      3  1.3|
                                            __________________________________________________________________________|____________|
   Mesentery                               | +                                +                       +              +|   6        |
      Inflammation, Acute                  |                                                                         3|      3  2.7|
      Fat, Necrosis                        | 4                                3                       4               |      3  3.7|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +     M  +                          +  +              +           A  +|  13        |
      Cyst                                 | X                                                                        |      1     |
      Acinus, Atrophy                      | 4                                                        3               |      3  2.7|
      Duct, Dilatation                     |                                                          3               |      1  3.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |          M  +                          +  +                          +  +|  12        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acanthosis                           |                            1     3                       1               |      5  1.8|
      Hyperkeratosis                       |       2     2                    2        2              2     2         |     10  1.9|
      Necrosis                             |                                                                2         |      2  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hemorrhage                           |       1                                                                  |      1  1.0|
      Inflammation, Chronic Active         | 1     2                                1                                 |      4  1.3|
      Mineralization                       |                                        1                                 |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  13                                                               
NTP Experiment-Test: 05023-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                    PENTAERYTHRITOL TETRANITRATE                               Date: 05/01/97  
Route: DOSED FEED                                                                                                 Time: 13:22:26  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 5| 5| 7| 7| 7| 7| 7| 7| 7| 6| 6| 5| 7| 7| 7| 7| 6| 7| 7| 7| 6| 5|            |
                             DAY ON TEST   | 3| 3| 1| 6| 2| 3| 3| 3| 3| 3| 3| 3| 9| 3| 6| 3| 3| 3| 2| 7| 3| 3| 2| 7| 2|            |
                                           | 1| 1| 4| 8| 1| 1| 1| 1| 1| 1| 2| 2| 6| 4| 8| 2| 2| 2| 8| 4| 2| 2| 8| 0| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|      A     |
    2.5%                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |          +  +                          +  +                          +  +|  12        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |          +  +                          +  +                          +  +|  12        |
      Capsule, Hyperplasia                 |                                        2                                2|      7  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |          +  +                          +  +                          +  +|  12        |
      Hyperplasia                          |                                        2                                2|      7  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |          +  +                          +  +                          M  +|  11        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +        M  +                          +  +              +           A  +|  12        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |          M  +                          +  +                          M  M|   8        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |          +  +     +                    +  +              +           A  +|  15        |
      Pars Distalis, Angiectasis           |                   2                                                      |      2  2.0|
      Pars Distalis, Hyperplasia           |                                           1                              |      2  1.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |          +  +                          +  +                          +  +|  12        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   |          +  +              +        +  +  +                 +        +  +|  19        |
      Abscess                              |                                                                          |      2  4.0|
      Cyst                                 |                            X                                             |      2     |
      Degeneration, Cystic                 |                                     2                                    |      6  2.8|
      Hemorrhage                           |                                                                          |      1  3.0|
      Bilateral, Abscess                   |                                                                         4|      2  4.0|
                                            __________________________________________________________________________|____________|
   Oviduct                                 |                                        +  +                              |   4        |
                                            __________________________________________________________________________|____________|
   Uterus                                  |    +  A  +  +           +  +  +        +  +  +  +  +  +     +        +  +|  37        |
      Abscess                              |                                                                          |      1  3.0|
      Angiectasis                          |                                                                          |      1  2.0|
      Hemorrhage                           |                                                       2                  |      1  2.0|
      Inflammation, Chronic Active         |                                                                         2|      3  1.7|
      Pigmentation                         |                                                       2                  |      1  2.0|
      Endometrium, Hyperplasia             |    2                    2     3              3  2  2                     |     19  2.5|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |          +  +                          +  +                          +  +|  12        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |    +     +  +                    +     +  M                 +        +  +|  17        |
      Axillary, Hematopoietic Cell         |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  14                                                               
NTP Experiment-Test: 05023-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                    PENTAERYTHRITOL TETRANITRATE                               Date: 05/01/97  
Route: DOSED FEED                                                                                                 Time: 13:22:26  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 5| 5| 7| 7| 7| 7| 7| 7| 7| 6| 6| 5| 7| 7| 7| 7| 6| 7| 7| 7| 6| 5|            |
                             DAY ON TEST   | 3| 3| 1| 6| 2| 3| 3| 3| 3| 3| 3| 3| 9| 3| 6| 3| 3| 3| 2| 7| 3| 3| 2| 7| 2|            |
                                           | 1| 1| 4| 8| 1| 1| 1| 1| 1| 1| 2| 2| 6| 4| 8| 2| 2| 2| 8| 4| 2| 2| 8| 0| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|      A     |
    2.5%                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
          Proliferation                    |                                                                          |      1  1.0|
      Axillary, Infiltration Cellular,     |                                                                          |            |
           Plasma Cell                     |                                                                          |      1  2.0|
      Lumbar, Hematopoietic Cell           |                                                                          |            |
          Proliferation                    |                                                                          |      1  2.0|
      Lumbar, Infiltration Cellular,       |                                                                          |            |
          Plasma Cell                      |                                                                          |      1  2.0|
      Mediastinal, Infiltration Cellular,  |                                                                          |            |
           Plasma Cell                     |                                                                          |      2  2.5|
      Renal, Hematopoietic Cell            |                                                                          |            |
          Proliferation                    |                                                                          |      1  2.0|
      Renal, Infiltration Cellular, Plasma |                                                                          |            |
          Cell                             |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |          M  +                          M  M                          +  M|   8        |
      Hematopoietic Cell Proliferation     |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |    +     A  +                    +     +  M                 +        +  +|  12        |
      Angiectasis                          |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     |                                                                         2|      3  1.7|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hematopoietic Cell Proliferation     |    2  1                 2                    2           3        2     3|     20  2.3|
      Lymphoid Follicle, Hyperplasia       |                      2  2     2                                          |      5  2.2|
                                            __________________________________________________________________________|____________|
   Thymus                                  |          +  +                          +  M                          +  +|  10        |
      Hyperplasia, Lymphoid                |                                        2                                 |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |          M  +                          M  M                       +  M  M|   5        |
      Necrosis                             |                                                                   2      |      1  2.0|
                                            __________________________________________________________________________|____________|
   Skin                                    |          +  +                          +  +                          +  +|  13        |
      Necrosis                             |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |          +  +                          +  +                          +  +|  12        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |             +                             +                              |   2        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |          +  +                          +  +                          +  +|  12        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  15                                                               
NTP Experiment-Test: 05023-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                    PENTAERYTHRITOL TETRANITRATE                               Date: 05/01/97  
Route: DOSED FEED                                                                                                 Time: 13:22:26  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 5| 5| 7| 7| 7| 7| 7| 7| 7| 6| 6| 5| 7| 7| 7| 7| 6| 7| 7| 7| 6| 5|            |
                             DAY ON TEST   | 3| 3| 1| 6| 2| 3| 3| 3| 3| 3| 3| 3| 9| 3| 6| 3| 3| 3| 2| 7| 3| 3| 2| 7| 2|            |
                                           | 1| 1| 4| 8| 1| 1| 1| 1| 1| 1| 2| 2| 6| 4| 8| 2| 2| 2| 8| 4| 2| 2| 8| 0| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|      A     |
    2.5%                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |       +  +  +                          +  +           +              +  +|  16        |
      Hemorrhage                           |                                                                          |      1  1.0|
      Infiltration Cellular, Histiocyte    |                                                       2                  |      1  2.0|
      Inflammation, Acute                  |                                                                         2|      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    |          M  +                          +  M                          M  +|   9        |
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Acute                           |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 |       +  +  +                          +  +           +              +  +|  16        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                             +            |   2        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |    +     +  +                          +  +  +                       +  +|  14        |
      Inflammation, Acute                  |                                                                         2|      1  2.0|
      Papilla, Mineralization              |                                           1                              |      2  1.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |          +  +                          +  +                          A  +|  11        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  16                                                               
NTP Experiment-Test: 05023-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                    PENTAERYTHRITOL TETRANITRATE                               Date: 05/01/97  
Route: DOSED FEED                                                                                                 Time: 13:22:26  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 4| 7| 7| 7| 7| 2| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 1| 3| 3| 3| 7| 0| 3| 3| 3| 8| 6| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3|             
                                           | 0| 0| 0| 0| 1| 0| 0| 0| 5| 5| 0| 0| 0| 9| 3| 0| 0| 0| 0| 8| 0| 0| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    5.0%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  A  +  +  +  +  +  +  +  +  +  M  +  M  +  +  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Parasite                             |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  M  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  +|             
      Epithelium, Hyperplasia              |                            2                                             |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                                                          |             
      Clear Cell Focus                     |                                                                          |             
      Eosinophilic Focus                   | X                                                           X            |             
      Fatty Change, Focal                  |                                              1              1            |             
      Necrosis                             |                                                 2  2                     |             
      Pigmentation                         |                                                    2                     |             
      Thrombosis                           |                                                    X                     |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                 +                        |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
      Inflammation, Chronic Active         |                            2                                             |             
      Necrosis                             |                                                                          |             
      Acinus, Atrophy                      |                            1                    4                        |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                     1                       1            |             
      Edema                                |                                                                      1   |             
      Hyperkeratosis                       |             2                       2  2     1     1              1  1   |             
      Inflammation, Chronic Active         |                                                                      1   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic Active         |                      2        1     2  1           2        1           1|             
      Mineralization                       |                                                    1                     |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Incisor, Developmental Malformation  |                                                                          |             
      Incisor, Inflammation, Acute         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  17                                                               
NTP Experiment-Test: 05023-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                    PENTAERYTHRITOL TETRANITRATE                               Date: 05/01/97  
Route: DOSED FEED                                                                                                 Time: 13:22:26  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 4| 7| 7| 7| 7| 2| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 1| 3| 3| 3| 7| 0| 3| 3| 3| 8| 6| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3|             
                                           | 0| 0| 0| 0| 1| 0| 0| 0| 5| 5| 0| 0| 0| 9| 3| 0| 0| 0| 0| 8| 0| 0| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    5.0%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Capsule, Hyperplasia                 | 1     1  2  1     2  1  2  1  2  2  2  2     2  2  2  1     1  2  3  1  2|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 1     1  2        2  1  2  1  2  2  2  2     2  2     1     1  2  3  1  2|             
      Hypertrophy                          |                                                    2                    1|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |             2                                                            |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  +  +  M  +  +  M  M  M  M  +  M  +  M  +  +  M  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  M  +  +  +  M  +  +  +  +  M  M  +  +  +  +  +  M  +  +  +  +|             
      Pars Distalis, Angiectasis           |                                                                          |             
      Pars Distalis, Hyperplasia           |    1              1              2                                       |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Hyperplasia         |                                                    2                     |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                2                                                         |             
      Cyst                                 | X              X                    X        X  X  X                     |             
      Degeneration, Cystic                 |                   2                                                      |             
      Hemorrhage                           |                                                                          |             
      Mineralization                       |                   2                                                      |             
      Necrosis                             |                                                                          |             
      Pigmentation                         |                   2                                                      |             
      Thrombosis                           |                   X                                                      |             
      Bilateral, Abscess                   |                                                                          |             
                                            __________________________________________________________________________|             
   Oviduct                                 | +  +  +  +     +  +  +  +  +  +  +              +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                         2                                                |             
      Necrosis                             |                                                                1         |             
      Endometrium, Hyperplasia             | 2  2  2  2     3  2  2  2  3  2  2  3  2     3  2  2  3     2     2  2  2|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Myelofibrosis                        |             1                                      1                     |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lumbar, Infiltration Cellular,       |                                                                          |             
          Plasma Cell                      |                         2                                                |             
      Pancreatic, Hematopoietic Cell       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  18                                                               
NTP Experiment-Test: 05023-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                    PENTAERYTHRITOL TETRANITRATE                               Date: 05/01/97  
Route: DOSED FEED                                                                                                 Time: 13:22:26  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 4| 7| 7| 7| 7| 2| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 1| 3| 3| 3| 7| 0| 3| 3| 3| 8| 6| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3|             
                                           | 0| 0| 0| 0| 1| 0| 0| 0| 5| 5| 0| 0| 0| 9| 3| 0| 0| 0| 0| 8| 0| 0| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    5.0%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
          Proliferation                    |                                                                      1   |             
      Renal, Infiltration Cellular, Plasma |                                                                          |             
          Cell                             |                         2                                                |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  M  +  +  M  +  +  M  M  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                1         |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |    1  2  1        1     2     1  2  2  2        2  1  1     1  2  1  2  2|             
      Hemorrhage                           |                                                                          |             
      Necrosis                             |                                                                          |             
      Lymphoid Follicle, Hyperplasia       |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  M  +  +  +  +  +  +  +  M  +  +  +  M  +  M  +  +  M  +  +  +  +  M|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  M  M  M  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  M  M  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +|             
      Inflammation, Chronic Active         |                                                    2                     |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                 +                        |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |             2                                      1                     |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                          1               |             
      Hemorrhage                           |                            1                                            2|             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Pleura, Inflammation, Acute          |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                              +                           |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                              +                           |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Casts                                |                                                                          |             
      Cyst                                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  19                                                               
NTP Experiment-Test: 05023-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                    PENTAERYTHRITOL TETRANITRATE                               Date: 05/01/97  
Route: DOSED FEED                                                                                                 Time: 13:22:26  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 4| 7| 7| 7| 7| 2| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 1| 3| 3| 3| 7| 0| 3| 3| 3| 8| 6| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3|             
                                           | 0| 0| 0| 0| 1| 0| 0| 0| 5| 5| 0| 0| 0| 9| 3| 0| 0| 0| 0| 8| 0| 0| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    5.0%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Glomerulosclerosis                   |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Papilla, Mineralization              |                                                                          |             
      Renal Tubule, Pigmentation           |                                                          2               |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  20                                                               
NTP Experiment-Test: 05023-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                    PENTAERYTHRITOL TETRANITRATE                               Date: 05/01/97  
Route: DOSED FEED                                                                                                 Time: 13:22:26  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| 6| 6| 5|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 5| 0| 3| 3| 6| 4| 8|            |
                                           | 1| 1| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 4| 7| 1| 1| 3| 6| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      A     |
    5.0%                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|  48        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  M  A  +|  43        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Parasite                             |                               1                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  +|  44        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  A  +  +  +  A  +|  43        |
      Epithelium, Hyperplasia              |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  +  A  +|  44        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Basophilic Focus                     |                   X                       X                              |      2     |
      Clear Cell Focus                     |             X                                                            |      1     |
      Eosinophilic Focus                   |    X                                                                     |      3     |
      Fatty Change, Focal                  |                                                                          |      2  1.0|
      Necrosis                             |                                                                          |      2  2.0|
      Pigmentation                         |                                                                          |      1  2.0|
      Thrombosis                           |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Fibrosis                             |       1                                                                  |      1  1.0|
      Inflammation, Chronic Active         |       3                                                                  |      2  2.5|
      Necrosis                             |          2                                                           2   |      2  2.0|
      Acinus, Atrophy                      |                                                                   1      |      3  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|  48        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Acanthosis                           |    1                                      1                              |      4  1.0|
      Edema                                |                                                                          |      1  1.0|
      Hyperkeratosis                       |    1                                      1     2  2     1        1      |     13  1.4|
      Inflammation, Chronic Active         |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hyperplasia                          |                                           2                              |      1  2.0|
      Inflammation, Chronic Active         |    2                       1              2                              |     10  1.5|
      Mineralization                       |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |       +                                                                  |   1        |
      Incisor, Developmental Malformation  |       X                                                                  |      1     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  21                                                               
NTP Experiment-Test: 05023-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                    PENTAERYTHRITOL TETRANITRATE                               Date: 05/01/97  
Route: DOSED FEED                                                                                                 Time: 13:22:26  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| 6| 6| 5|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 5| 0| 3| 3| 6| 4| 8|            |
                                           | 1| 1| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 4| 7| 1| 1| 3| 6| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      A     |
    5.0%                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Incisor, Inflammation, Acute         |       1                                                                  |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Chronic Active         |                               1                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Capsule, Hyperplasia                 | 2  2  2  2  1  1  1  1  2  2  2  1  2  2  2  3  2        2  2  2  1     2|     43  1.7|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          | 2  2     2  1  1  1  1  2  2     1  2  2  2  2  2        2  2  2  1      |     38  1.7|
      Hypertrophy                          |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  M  M  M  +  M  +  +  +  +  +  M  +  +  +  +  M  +  M  +|  34        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  M  +  +  +  +|  42        |
      Pars Distalis, Angiectasis           |                      2                                                   |      1  2.0|
      Pars Distalis, Hyperplasia           |    2  1                          2  2           1     2              2   |     10  1.6|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|  47        |
      Follicular Cell, Hyperplasia         |                                              1                           |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|  48        |
      Angiectasis                          |       3                                                  2               |      3  2.3|
      Cyst                                 |                            X        X                       X            |      9     |
      Degeneration, Cystic                 |          2                                                               |      2  2.0|
      Hemorrhage                           |       2                                                     1            |      2  1.5|
      Mineralization                       |                                                             2            |      2  2.0|
      Necrosis                             |                                              2                           |      1  2.0|
      Pigmentation                         |                                                             2            |      2  2.0|
      Thrombosis                           |                                                                          |      1     |
      Bilateral, Abscess                   |                                                    3                     |      1  3.0|
                                            __________________________________________________________________________|____________|
   Oviduct                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M     +  +  +  +  +  +|  43        |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Chronic Active         |                                                    3                     |      2  2.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  22                                                               
NTP Experiment-Test: 05023-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                    PENTAERYTHRITOL TETRANITRATE                               Date: 05/01/97  
Route: DOSED FEED                                                                                                 Time: 13:22:26  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| 6| 6| 5|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 5| 0| 3| 3| 6| 4| 8|            |
                                           | 1| 1| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 4| 7| 1| 1| 3| 6| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      A     |
    5.0%                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Necrosis                             |                                                                          |      1  1.0|
      Endometrium, Hyperplasia             |    2  2  2  2  2  2     2  2  2  1  2  2  2     2           1  2  3      |     38  2.1|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Myelofibrosis                        |       2                       1                                          |      4  1.3|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +|  48        |
      Lumbar, Infiltration Cellular,       |                                                                          |            |
          Plasma Cell                      |                                                                          |      1  2.0|
      Pancreatic, Hematopoietic Cell       |                                                                          |            |
          Proliferation                    |                                                                          |      1  1.0|
      Renal, Infiltration Cellular, Plasma |                                                                          |            |
          Cell                             |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  M  M  +|  42        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +|  46        |
      Angiectasis                          |                      1                                                   |      1  1.0|
      Hematopoietic Cell Proliferation     |                      1                             3                     |      3  1.7|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hematopoietic Cell Proliferation     | 1  1  1  1  1  1  1     1  1  2  2     2  1  3     3        1           3|     34  1.5|
      Hemorrhage                           |                                                                      2   |      1  2.0|
      Necrosis                             |                                                                      4   |      1  4.0|
      Lymphoid Follicle, Hyperplasia       |                   3                                      2               |      2  2.5|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  M  M  +|  40        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  M  +  +  M  M  M  M  +  M  +  M  +  +  +  +  +  +  +  +  +  +  M  +  M|  34        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Mineralization                       |                                                                          |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  23                                                               
NTP Experiment-Test: 05023-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                    PENTAERYTHRITOL TETRANITRATE                               Date: 05/01/97  
Route: DOSED FEED                                                                                                 Time: 13:22:26  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| 6| 6| 5|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 5| 0| 3| 3| 6| 4| 8|            |
                                           | 1| 1| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 4| 7| 1| 1| 3| 6| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      A     |
    5.0%                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Edema                                |                                                                          |      1  1.0|
      Hemorrhage                           |                      1                                                   |      3  1.3|
      Alveolar Epithelium, Hyperplasia     |                                        2                                 |      1  2.0|
      Pleura, Inflammation, Acute          |                                                    3                     |      1  3.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                     +                             +      |   3        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                  +  +        +     +           +  +      |   7        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Casts                                |                                                    2                     |      1  2.0|
      Cyst                                 |       X                                            X                     |      2     |
      Glomerulosclerosis                   |                                                    2                     |      1  2.0|
      Inflammation, Chronic Active         |                                                    2                     |      1  2.0|
      Papilla, Mineralization              |                   1                                                      |      1  1.0|
      Renal Tubule, Pigmentation           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  24                                                               
NTP Experiment-Test: 05023-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                    PENTAERYTHRITOL TETRANITRATE                               Date: 05/01/97  
Route: DOSED FEED                                                                                                 Time: 13:22:26  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 6| 7| 7| 2| 2| 1| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 6| 6| 6|             
                             DAY ON TEST   | 3| 3| 3| 8| 8| 3| 3| 4| 0| 8| 3| 3| 3| 3| 2| 3| 3| 3| 6| 5| 3| 1| 6| 6| 0|             
                                           | 1| 1| 1| 2| 2| 1| 2| 7| 7| 4| 1| 1| 1| 2| 7| 1| 1| 1| 7| 0| 2| 5| 0| 0| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  A  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  M  A  A  +  +  +  +  A  +  +  +  +  +  +  A  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  A  M  +  +  +  +  A  +  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  M  A  M  +  +  +  +  A  +  +  +  +  M  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  M  A  +  +  +  +  +  A  +  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  A  M  +  +  +  +  A  +  +  +  +  +  +  A  +  +  +|             
      Lymphoid Nodule, Hyperplasia         |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  A  M  +  +  +  +  A  +  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Eosinophilic Focus                   |                                                                          |             
      Fatty Change, Diffuse                |                                                                          |             
      Fatty Change, Focal                  |                                        1                 2  1           2|             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Infarct                              |                                                    3                     |             
      Mineralization                       |                                                    2                     |             
      Mixed Cell Focus                     |                                                                          |             
      Necrosis                             |                                                                          |             
      Pigmentation                         |                                                    2                     |             
      Bile Duct, Hyperplasia               |                                                    2                     |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                       +           +      |             
      Inflammation, Acute                  |                                                                          |             
      Fat, Mineralization                  |                                                                          |             
      Fat, Necrosis                        |                                                       3           4      |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Necrosis                     |                                                                          |             
      Artery, Necrosis, Fibrinoid          |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                                                          |             
      Hyperkeratosis                       |                                                       1                  |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                             1            |             
      Inflammation, Chronic Active         |                                                             2            |             
      Mineralization                       |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |       +                                                                  |             
      Incisor, Developmental Malformation  |       1                                                                  |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  25                                                               
NTP Experiment-Test: 05023-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                    PENTAERYTHRITOL TETRANITRATE                               Date: 05/01/97  
Route: DOSED FEED                                                                                                 Time: 13:22:26  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 6| 7| 7| 2| 2| 1| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 6| 6| 6|             
                             DAY ON TEST   | 3| 3| 3| 8| 8| 3| 3| 4| 0| 8| 3| 3| 3| 3| 2| 3| 3| 3| 6| 5| 3| 1| 6| 6| 0|             
                                           | 1| 1| 1| 2| 2| 1| 2| 7| 7| 4| 1| 1| 1| 2| 7| 1| 1| 1| 7| 0| 2| 5| 0| 0| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Capsule, Hyperplasia                 | 1  1  1     2  1  1        1  1  1  1  1        2  1  2     1     1  1  1|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                                                                          |             
      Hyperplasia                          |             2                                   2     2                  |             
      Hypertrophy                          |                   1              1     1     1                    1      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                         1|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  M  +  M  +  M  M  +  +  M  +  +  +  +  M  +  +  M  M  +  M  M  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Intermedia, Hyperplasia         |                               1                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Follicle, Cyst                       |                                                                   4      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         |    +  +        +  +     M           +  +     +     +     +     +        M|             
      Dilatation                           |    2  2           2                                2           2         |             
      Inflammation, Chronic Active         |       1        2                       2                 1               |             
      Mineralization                       |                                                                          |             
      Necrosis                             |                                     3  1                                 |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  M  +  +  M  +  M  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                            3                                             |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bacterium                            |                                                                2         |             
      Concretion                           |       2                                                                  |             
      Fibrosis                             |       2                                                                  |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Artery, Necrosis, Fibrinoid          |                                                                          |             
      Seminiferous Tubule, Atrophy         |       1                                2                                 |             
      Seminiferous Tubule, Mineralization  |                                        1                                 |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Axillary, Angiectasis                |                                              2                           |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  26                                                               
NTP Experiment-Test: 05023-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                    PENTAERYTHRITOL TETRANITRATE                               Date: 05/01/97  
Route: DOSED FEED                                                                                                 Time: 13:22:26  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 6| 7| 7| 2| 2| 1| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 6| 6| 6|             
                             DAY ON TEST   | 3| 3| 3| 8| 8| 3| 3| 4| 0| 8| 3| 3| 3| 3| 2| 3| 3| 3| 6| 5| 3| 1| 6| 6| 0|             
                                           | 1| 1| 1| 2| 2| 1| 2| 7| 7| 4| 1| 1| 1| 2| 7| 1| 1| 1| 7| 0| 2| 5| 0| 0| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Axillary, Infiltration Cellular,     |                                                                          |             
           Lymphocyte                      |                                     2                                    |             
      Lumbar, Hematopoietic Cell           |                                                                          |             
          Proliferation                    |                                                                          |             
      Renal, Hematopoietic Cell            |                                                                          |             
          Proliferation                    |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  M  M  +  +  M  M  M  M  +  M  +  M  +  +  M  +  M  M  M  +  +  M  M  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  M  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 1  2  2  2        1              2  1           1  2  2     2           1|             
      Hematopoietic Cell Proliferation     | 1  1  1  1        2              2  2           1     2                  |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Hematopoietic Cell Proliferation     |       2  1  1  1  1  2     3  1  2  2  1  1     1  1  3  2  1     3  2   |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  M  +  +  M  +  +  +  +  +  M  +  +  M  +  +  +  +  M  +  +|             
      Atrophy                              |                      2                                                   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  +  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  +  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                                                          |             
      Hemorrhage                           |                            2                                             |             
      Necrosis                             |                   2              1     2                                 |             
      Prepuce, Hemorrhage                  |                         2                                                |             
      Prepuce, Inflammation, Acute         |                         3                                                |             
      Prepuce, Necrosis                    |                         4  4                                             |             
      Scrotal, Epithelium, Hyperplasia,    |                                                                          |             
           Basal Cell                      |                                  2                                       |             
      Subcutaneous Tissue, Mineralization  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Tarsal, Hyperostosis                 | 2     1  2  2     3              2  3  3     2  2  3  3  3  3           4|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                               2           2                          2   |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atelectasis                          |                                                                          |             
      Congestion                           |                                              2           1               |             
      Edema                                |                                                                          |             
      Hemorrhage                           | 1           1                                                            |             
      Infiltration Cellular, Histiocyte    | 1  1                                                                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  27                                                               
NTP Experiment-Test: 05023-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                    PENTAERYTHRITOL TETRANITRATE                               Date: 05/01/97  
Route: DOSED FEED                                                                                                 Time: 13:22:26  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 6| 7| 7| 2| 2| 1| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 6| 6| 6|             
                             DAY ON TEST   | 3| 3| 3| 8| 8| 3| 3| 4| 0| 8| 3| 3| 3| 3| 2| 3| 3| 3| 6| 5| 3| 1| 6| 6| 0|             
                                           | 1| 1| 1| 2| 2| 1| 2| 7| 7| 4| 1| 1| 1| 2| 7| 1| 1| 1| 7| 0| 2| 5| 0| 0| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Inflammation, Chronic Active         |                      2                                                   |             
      Alveolar Epithelium, Hyperplasia     |                                                                1         |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  M  +  +  +  +  +  +  M  M  +|             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |             +                                                            |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                          2               |             
      Cyst                                 |                X                                                         |             
      Fibrosis                             |                1                                                         |             
      Inflammation, Acute                  |                                                                2         |             
      Cortex, Mineralization               |    1  1              2     2        1     1                    1     1   |             
      Papilla, Mineralization              |    1                                                                     |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  +  +  +  +  A  +  +  +|             
      Calculus Micro Observation Only      |                                     X                                    |             
      Inflammation, Chronic Active         |                      1     2                                             |             
      Transitional Epithelium, Hyperplasia |                                                                      1   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  28                                                               
NTP Experiment-Test: 05023-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                    PENTAERYTHRITOL TETRANITRATE                               Date: 05/01/97  
Route: DOSED FEED                                                                                                 Time: 13:22:26  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 5| 5| 4| 7| 7| 7| 6| 0| 7| 5| 4| 7| 7| 6| 5| 4| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 9| 3| 3| 3| 8| 6| 5| 3| 3| 3| 2| 2| 3| 7| 5| 3| 1| 0| 4| 1| 3|            |
                                           | 1| 1| 1| 1| 5| 2| 2| 2| 5| 4| 6| 2| 2| 2| 3| 6| 2| 8| 6| 2| 7| 0| 3| 4| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    CONTROL                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  M  +  +  +  +  +  +  +  +  A  +  M  +  +     +  +  +  +  +  M  +  +  +|  43        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +     +  +  +  +  +  +  +  M  +|  41        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +     +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +     +  +  +  +  +  +  +  +  +|  44        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +     +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  M  +  +  +  A  +  +  +  +     +  +  M  +  +  +  +  +  +|  40        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +     +  +  +  +  +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +     +  +  +  +  +  +  +  +  +|  44        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +     +  +  +  +  +  +  +  +  +|  44        |
      Lymphoid Nodule, Hyperplasia         |    2                                                                     |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +     +  +  +  +  +  +  +  +  +|  44        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +     +  +  +  +  +  +  +  +  +|  48        |
      Cyst                                 |                                                       X                  |      1     |
      Eosinophilic Focus                   |    X                                                                     |      1     |
      Fatty Change, Diffuse                |                                                                         2|      1  2.0|
      Fatty Change, Focal                  |                                                       1  1               |      6  1.3|
      Hematopoietic Cell Proliferation     |             2                                                            |      1  2.0|
      Infarct                              |                                                                          |      1  3.0|
      Mineralization                       |                                                                          |      1  2.0|
      Mixed Cell Focus                     |                                                          X               |      1     |
      Necrosis                             |             3                                                           2|      2  2.5|
      Pigmentation                         |                                                                          |      1  2.0|
      Bile Duct, Hyperplasia               |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |    +  +                                                                  |   4        |
      Inflammation, Acute                  |    3                                                                     |      1  3.0|
      Fat, Mineralization                  |       1                                                                  |      1  1.0|
      Fat, Necrosis                        |       3                                                                  |      3  3.3|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +     +  +  +  +  +  +  +  +  +|  47        |
      Acinus, Necrosis                     |                      1                                                   |      1  1.0|
      Artery, Necrosis, Fibrinoid          |                                                                      3   |      1  3.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +     +  +  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +     +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +     +  +  +  +  +  +  +  +  +|  47        |
      Acanthosis                           |                                  1     1                                2|      3  1.3|
      Hyperkeratosis                       |                                  2                                      2|      3  1.7|
      Inflammation, Chronic Active         |                                                          1               |      1  1.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +     +  +  +  +  +  +  +  +  +|  47        |
      Hyperplasia                          |                                                                          |      1  1.0|
      Inflammation, Chronic Active         |                                     2                                    |      2  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  29                                                               
NTP Experiment-Test: 05023-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                    PENTAERYTHRITOL TETRANITRATE                               Date: 05/01/97  
Route: DOSED FEED                                                                                                 Time: 13:22:26  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 5| 5| 4| 7| 7| 7| 6| 0| 7| 5| 4| 7| 7| 6| 5| 4| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 9| 3| 3| 3| 8| 6| 5| 3| 3| 3| 2| 2| 3| 7| 5| 3| 1| 0| 4| 1| 3|            |
                                           | 1| 1| 1| 1| 5| 2| 2| 2| 5| 4| 6| 2| 2| 2| 3| 6| 2| 8| 6| 2| 7| 0| 3| 4| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    CONTROL                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Mineralization                       |                                           1                              |      1  1.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
      Incisor, Developmental Malformation  |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +|  48        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  M  +  A  +  +  +  +     +  +  +  +  +  +  +  +  +|  46        |
      Capsule, Hyperplasia                 | 1  1  1  1  1  1  1        2     1  1  1  1     1     1  2  2  1  1     1|     37  1.2|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  M  +  A  +  +  +  +     +  +  +  +  +  +  +  +  +|  46        |
      Accessory Adrenal Cortical Nodule    |                                        X                                 |      1     |
      Hyperplasia                          |                                                                          |      3  2.0|
      Hypertrophy                          |                                                          1  1            |      7  1.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  M  +  A  +  +  +  +     +  +  +  +  +  +  M  +  +|  45        |
      Hyperplasia                          |                      1                 1        1                        |      4  1.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +     +  +  +  +  +  +  +  +  +|  47        |
      Hyperplasia                          | 2     2                                                  2               |      3  2.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  M  +  +  +  +  +  +  A  +  +  +  M     +  +  M  +  M  +  M  +  M|  32        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +     +  M  +  +  +  +  +  +  +|  45        |
      Pars Intermedia, Hyperplasia         |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +     +  +  +  +  +  +  +  +  +|  46        |
      Follicle, Cyst                       |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +     +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |    +     +              +  +        +                    +  +     +  +   |  19        |
      Dilatation                           |    2                                2                       3            |      8  2.1|
      Inflammation, Chronic Active         |          2                                                  1     1      |      7  1.4|
      Mineralization                       |                                     2                                    |      1  2.0|
      Necrosis                             |    2                                2                    2               |      5  2.0|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +     +  +  +  +  +  +  +  M  +|  43        |
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +     +  +  +  +  +  +  +  +  +|  47        |
      Bacterium                            |                                                                          |      1  2.0|
      Concretion                           |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  30                                                               
NTP Experiment-Test: 05023-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                    PENTAERYTHRITOL TETRANITRATE                               Date: 05/01/97  
Route: DOSED FEED                                                                                                 Time: 13:22:26  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 5| 5| 4| 7| 7| 7| 6| 0| 7| 5| 4| 7| 7| 6| 5| 4| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 9| 3| 3| 3| 8| 6| 5| 3| 3| 3| 2| 2| 3| 7| 5| 3| 1| 0| 4| 1| 3|            |
                                           | 1| 1| 1| 1| 5| 2| 2| 2| 5| 4| 6| 2| 2| 2| 3| 6| 2| 8| 6| 2| 7| 0| 3| 4| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    CONTROL                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Fibrosis                             |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +     +  +  +  +  +  +  +  +  +|  48        |
      Artery, Necrosis, Fibrinoid          |                                                                      2   |      1  2.0|
      Seminiferous Tubule, Atrophy         |                                                                          |      2  1.5|
      Seminiferous Tubule, Mineralization  |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +     +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +     +  +  +  +  +  +  +  +  +|  46        |
      Axillary, Angiectasis                |                                                                          |      1  2.0|
      Axillary, Infiltration Cellular,     |                                                                          |            |
           Lymphocyte                      |                                                                          |      1  2.0|
      Lumbar, Hematopoietic Cell           |                                                                          |            |
          Proliferation                    |                         2                                                |      1  2.0|
      Renal, Hematopoietic Cell            |                                                                          |            |
          Proliferation                    |                         2                                                |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  M  +  M  +  M  A  M  +  +  M     M  +  M  M  +  M  +  +  +|  25        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  M  +  +  +  +  +  +  +  A  +  +  +  +     +  +  +  +  +  +  +  +  +|  44        |
      Angiectasis                          |                         2  2        1  3  3     2           2  3  1     2|     22  1.8|
      Hematopoietic Cell Proliferation     |                         1  3           1  2     1              2         |     15  1.5|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +     +  +  +  +  +  +  +  +  +|  47        |
      Angiectasis                          |       2                                                                  |      1  2.0|
      Hematopoietic Cell Proliferation     | 1  2  1  3  2  3     3  3  3        1  1  3     1  1  2  1  1  3     3   |     38  1.8|
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  +  M  +  +  M  M  M  +  +  A  +  M  +  +     M  +  +  +  +  +  +  +  +|  36        |
      Atrophy                              |                                           3                    3         |      3  2.7|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  M  M  M  +  M  M  M  M  M  M  M     +  M  M  M  M  +  M  M  M|   5        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +     +  +  +  +  +  +  +  +  +|  48        |
      Acanthosis                           |                                                                      1  2|      2  1.5|
      Hemorrhage                           |                            2                                             |      2  2.0|
      Necrosis                             |          3           2  3                                                |      6  2.2|
      Prepuce, Hemorrhage                  |                                                                          |      1  2.0|
      Prepuce, Inflammation, Acute         |                                                                      3   |      2  3.0|
      Prepuce, Necrosis                    |                                                                          |      2  4.0|
      Scrotal, Epithelium, Hyperplasia,    |                                                                          |            |
           Basal Cell                      |                                                                          |      1  2.0|
      Subcutaneous Tissue, Mineralization  |                2                                                         |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  31                                                               
NTP Experiment-Test: 05023-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                    PENTAERYTHRITOL TETRANITRATE                               Date: 05/01/97  
Route: DOSED FEED                                                                                                 Time: 13:22:26  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 5| 5| 4| 7| 7| 7| 6| 0| 7| 5| 4| 7| 7| 6| 5| 4| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 9| 3| 3| 3| 8| 6| 5| 3| 3| 3| 2| 2| 3| 7| 5| 3| 1| 0| 4| 1| 3|            |
                                           | 1| 1| 1| 1| 5| 2| 2| 2| 5| 4| 6| 2| 2| 2| 3| 6| 2| 8| 6| 2| 7| 0| 3| 4| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    CONTROL                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +     +  +  +  +  +  +  +  +  +|  48        |
      Tarsal, Hyperostosis                 |                3        3  4     1  3  2                    2  2         |     23  2.5|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +     +  +  +  +  +  +  +  +  +|  48        |
      Mineralization                       | 1                                                                        |      4  1.8|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +     +  +  +  +  +  +  +  +  +|  47        |
      Atelectasis                          |                                                    2                     |      1  2.0|
      Congestion                           |                                                                          |      2  1.5|
      Edema                                |                                           2                              |      1  2.0|
      Hemorrhage                           |          2                                3           1     2            |      6  1.7|
      Infiltration Cellular, Histiocyte    |                                           1                              |      3  1.0|
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Alveolar Epithelium, Hyperplasia     |          2                                                               |      2  1.5|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  M  +  +  +  M  +  +  +  +  A  +  +  +  +     M  +  +  +  +  +  +  +  +|  40        |
      Inflammation, Acute                  |                      1                                                   |      1  1.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +     +  +  +  +  +  +  +  +  +|  47        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                       +                  |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +     +  +  +  +  +  +  +  +  +|  47        |
      Congestion                           |                                                                          |      1  2.0|
      Cyst                                 |                                                                          |      1     |
      Fibrosis                             |                                                                          |      1  1.0|
      Inflammation, Acute                  |                                                                          |      1  2.0|
      Cortex, Mineralization               | 1        1                                      1        1               |     12  1.2|
      Papilla, Mineralization              |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +     +  +  +  +  +  +  +  +  +|  45        |
      Calculus Micro Observation Only      |                   X                                                      |      2     |
      Inflammation, Chronic Active         |                                                                          |      2  1.5|
      Transitional Epithelium, Hyperplasia |                                                                          |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  32                                                               
NTP Experiment-Test: 05023-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                    PENTAERYTHRITOL TETRANITRATE                               Date: 05/01/97  
Route: DOSED FEED                                                                                                 Time: 13:22:26  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 6| 6| 7| 4| 7| 6| 6|             
                             DAY ON TEST   | 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 9| 2| 3| 8| 2| 5| 5|             
                                           | 0| 0| 0| 3| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 0| 1| 1| 5| 8| 0| 1| 2| 2| 6| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    2.5%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |          +                          +              +     +     +     +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +        +        +           +  +        +        A     A     A     +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         |          +                                         +     +     A     +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |          +                                         A     +     A     +  A|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |          +                                         +     A     A     +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |          +                                         A     A     A     +  A|             
                                            __________________________________________________________________________|             
   Intestine Small                         |          +                    +                    A     A     A     +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |          +                                         A     A     A     +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |          +                                         A     A     A     +  A|             
      Lymphoid Nodule, Hyperplasia         |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |          +                    +                    A     A     A     +  A|             
      Lymphoid Nodule, Hyperplasia         |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +     +  +  +  +  +  +     +  +        +        +  +  +     +     +  +|             
      Angiectasis                          |    2                                                                     |             
      Cyst                                 |                                                                          |             
      Hemorrhage                           |                                                                         3|             
      Necrosis                             |             2                             3                              |             
                                            __________________________________________________________________________|             
   Mesentery                               | +                          +                                      +      |             
      Fat, Mineralization                  |                                                                          |             
      Fat, Necrosis                        | 4                          4                                      4      |             
                                            __________________________________________________________________________|             
   Pancreas                                | +        +  +                                      +     +     +     +  +|             
                                            __________________________________________________________________________|             
   Salivary Glands                         |          +                                         +     A     +     +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Acanthosis                           |                                                                          |             
      Hyperkeratosis                       |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  A  A  +  +|             
      Inflammation, Chronic Active         |                            2                 1                           |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |          +                                         +     +     +     +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |          +     +                 +              +  +     +  +  +     +  +|             
      Capsule, Hyperplasia                 |          1     2                 1              2  1     1  1  1     1  2|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |          +     +                 +              +  +     +  +  +     +  +|             
      Hyperplasia                          |                                                                         2|             
      Hypertrophy                          |                2                                                         |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |          +     +                 +              +  +     +  +  +     +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +        +  +                                      +     +     +     +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |          M                                         +     M     M     M  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |          +                                         M     +     +     +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  33                                                               
NTP Experiment-Test: 05023-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                    PENTAERYTHRITOL TETRANITRATE                               Date: 05/01/97  
Route: DOSED FEED                                                                                                 Time: 13:22:26  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 6| 6| 7| 4| 7| 6| 6|             
                             DAY ON TEST   | 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 9| 2| 3| 8| 2| 5| 5|             
                                           | 0| 0| 0| 3| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 0| 1| 1| 5| 8| 0| 1| 2| 2| 6| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    2.5%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |          +                                         +     +     +     +  +|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |          +                                         +     +     +     +  +|             
                                            __________________________________________________________________________|             
   Penis                                   |                                                                         +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +     +     +                    +        +        +                 +   |             
      Dilatation                           |       3     3                             3                              |             
      Inflammation, Chronic Active         |       2     1                                                            |             
      Mineralization                       |                                                                          |             
      Necrosis                             | 3                                                  2                     |             
                                            __________________________________________________________________________|             
   Prostate                                |          +                                         +     +     A     +  +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |          +        +                             +  +  +  +     A     +  +|             
                                            __________________________________________________________________________|             
   Testes                                  |          +                                         +     +     +     +  +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |          +                                         +     +     +     +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +     +           +     +  +     +     +     +  +  +  A  +  +     +  +|             
      Iliac, Cyst                          |                                                                          |             
      Mediastinal, Hematopoietic Cell      |                                                                          |             
          Proliferation                    |                                           2                              |             
      Mediastinal, Infiltration Cellular,  |                                                                          |             
           Plasma Cell                     |                                           2                              |             
      Mediastinal, Infiltration Cellular,  |                                                                          |             
           Histiocyte                      |                            2                                             |             
      Pancreatic, Angiectasis              |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |          +                                         M     M     M     M  M|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |    +     +           +     M  +     +     +     +  +  +  A  +  +     +  +|             
      Angiectasis                          |    1                 3        1           3     2  2  2     2  1     2  2|             
      Hematopoietic Cell Proliferation     |                                     1     3     2     2     2        2  2|             
      Hyperplasia, Lymphoid                |    3                                                                     |             
                                            __________________________________________________________________________|             
   Spleen                                  |          +  +  +  +     +  +  +  +        +  +     +  +  +  +  +     +  +|             
      Atrophy                              |                                                          4               |             
      Hematopoietic Cell Proliferation     |                         3        3        4        2  3     2        3   |             
      Hemorrhage                           |                                                             2            |             
                                            __________________________________________________________________________|             
   Thymus                                  |          +                 +                       +     M     A     +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |          M                                         M     M     M     M  M|             
                                            __________________________________________________________________________|             
   Skin                                    |          M     +        +     +  +  +              +  +  +     +  +  +  +|             
      Inflammation, Acute                  |                                     2                                    |             
      Necrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  34                                                               
NTP Experiment-Test: 05023-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                    PENTAERYTHRITOL TETRANITRATE                               Date: 05/01/97  
Route: DOSED FEED                                                                                                 Time: 13:22:26  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 6| 6| 7| 4| 7| 6| 6|             
                             DAY ON TEST   | 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 9| 2| 3| 8| 2| 5| 5|             
                                           | 0| 0| 0| 3| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 0| 1| 1| 5| 8| 0| 1| 2| 2| 6| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    2.5%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Prepuce, Hemorrhage                  |                                                                         2|             
      Prepuce, Inflammation, Acute         |                                                          1               |             
      Prepuce, Inflammation, Chronic Active|                                                                          |             
      Prepuce, Necrosis                    |                                                                          |             
      Subcutaneous Tissue, Necrosis        |                                  3                                       |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +     +  +                    +  +     +     +  +  +  +  +  +     +  +|             
      Joint, Hyperostosis                  |                                  2                                       |             
      Tarsal, Hyperostosis                 |    2        2                       3     3     3     3  2  3            |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |          +                                         +     +     +     +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |       +  +     +     +              +           +  +     +     +     +  +|             
      Congestion                           |          2                                                               |             
      Hemorrhage                           |                                                                          |             
      Infiltration Cellular, Histiocyte    |                                     2           1                        |             
      Alveolar Epithelium, Hyperplasia     |                2                                                         |             
                                            __________________________________________________________________________|             
   Nose                                    |          +                                         +     +     +     M  +|             
                                            __________________________________________________________________________|             
   Trachea                                 |       +  +     +     +              +           +  +     +     +     +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                           +           +                  |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |          +        +                             +  +     +     +     +  +|             
      Casts Protein                        |                   1                                                      |             
      Cortex, Mineralization               |                                                    2           1         |             
      Papilla, Mineralization              |          1                                                               |             
      Renal Tubule, Regeneration           |                   2                                                      |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |          +           +        +     +  +           +     +     A     +  +|             
      Calculus Gross Observation           |                               X     X                                    |             
      Calculus Micro Observation Only      |                      X        X     X                                    |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  35                                                               
NTP Experiment-Test: 05023-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                    PENTAERYTHRITOL TETRANITRATE                               Date: 05/01/97  
Route: DOSED FEED                                                                                                 Time: 13:22:26  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 6| 2| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 5| 0| 6| 3| 3| 3| 3| 3|            |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 5| 0| 9| 1| 1| 1| 1| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
    2.5%                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |                                                    +  +  +               |  10        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |                                                    +  +  A               |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |                                                    +  +  +               |   8        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |                                                    +  +  A               |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |                                                    +  +  +               |   7        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |                                                    +  M  A               |   3        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |    +        +  +           +                       +  +  A               |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |                                                    +  +  A               |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |    +                       +                       +  +  A               |   6        |
      Lymphoid Nodule, Hyperplasia         |    3                                                                     |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |             +  +                                   +  +  A               |   7        |
      Lymphoid Nodule, Hyperplasia         |             3  3                                                         |      2  3.0|
                                            __________________________________________________________________________|____________|
   Liver                                   |                   +     +        +  +              +  +  +               |  24        |
      Angiectasis                          |                                                    2                     |      2  2.0|
      Cyst                                 |                                     X                                    |      1     |
      Hemorrhage                           |                                                                          |      1  3.0|
      Necrosis                             |                                                       1                  |      3  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |             +                                                            |   4        |
      Fat, Mineralization                  |             3                                                            |      1  3.0|
      Fat, Necrosis                        |             4                                                            |      4  4.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                |                   +              +                 +  +  +               |  13        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |                                                    +  +  +        +      |   9        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Acanthosis                           |                            2                                             |      1  2.0|
      Hyperkeratosis                       |                         2  2        1                                1   |      4  1.5|
      Inflammation, Chronic Active         |                      1                                                   |      1  1.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Inflammation, Chronic Active         |                         1  2           2                             2   |      6  1.7|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |                                                    +  +  +               |   9        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |                                                    +  +  +               |  13        |
      Capsule, Hyperplasia                 |                                                    1  2  1               |     13  1.3|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |                                                    +  +  +               |  13        |
      Hyperplasia                          |                                                                          |      1  2.0|
      Hypertrophy                          |                                                       2                  |      2  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  36                                                               
NTP Experiment-Test: 05023-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                    PENTAERYTHRITOL TETRANITRATE                               Date: 05/01/97  
Route: DOSED FEED                                                                                                 Time: 13:22:26  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 6| 2| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 5| 0| 6| 3| 3| 3| 3| 3|            |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 5| 0| 9| 1| 1| 1| 1| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
    2.5%                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |                                                    +  +  +               |  13        |
      Hyperplasia                          |                                                    1                     |      1  1.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |                   +              +                 +  +  +               |  13        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |                                                    M  +  M               |   3        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |                                                    +  +  +               |   8        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |                                                    +  +  M               |   8        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              |                                                    +  +  +               |   9        |
                                            __________________________________________________________________________|____________|
   Penis                                   |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +        +     +        +     +  +  +     +     +  +              +  +   |  19        |
      Dilatation                           | 2                                               2                        |      5  2.6|
      Inflammation, Chronic Active         |                               2  2        3     2                        |      6  2.0|
      Mineralization                       |                                                                      1   |      1  1.0|
      Necrosis                             |                         2                          2              3  2   |      6  2.3|
                                            __________________________________________________________________________|____________|
   Prostate                                |                                                    +  +  +               |   8        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |                                                    +  +  +               |  11        |
                                            __________________________________________________________________________|____________|
   Testes                                  |                                                    +  +  +               |   9        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |                                                    +  +  +               |   9        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +                 +     +  +  +  +  +              +  +  M               |  23        |
      Iliac, Cyst                          |                   X                                                      |      1     |
      Mediastinal, Hematopoietic Cell      |                                                                          |            |
          Proliferation                    |                                                                          |      1  2.0|
      Mediastinal, Infiltration Cellular,  |                                                                          |            |
           Plasma Cell                     |                                                                          |      1  2.0|
      Mediastinal, Infiltration Cellular,  |                                                                          |            |
           Histiocyte                      |                                                                          |      1  2.0|
      Pancreatic, Angiectasis              |                   3                                                      |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |                                                    +  +  M               |   3        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +                 +     +  +  +  +  +              +  +  M               |  22        |
      Angiectasis                          | 2                       2  1  2  4  3                 2                  |     18  2.1|
      Hematopoietic Cell Proliferation     | 1                                2  2                                    |     10  1.9|
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +        +                 +                       +  +  +  +     +     +|  26        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  37                                                               
NTP Experiment-Test: 05023-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                    PENTAERYTHRITOL TETRANITRATE                               Date: 05/01/97  
Route: DOSED FEED                                                                                                 Time: 13:22:26  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 6| 2| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 5| 0| 6| 3| 3| 3| 3| 3|            |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 5| 0| 9| 1| 1| 1| 1| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
    2.5%                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Atrophy                              |                                                                          |      1  4.0|
      Hematopoietic Cell Proliferation     | 2                          2                       2        2     2      |     12  2.5|
      Hemorrhage                           | 2                                                                        |      2  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  |                                                    +  +  M               |   7        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |                                                    M  M  M               |            |
                                            __________________________________________________________________________|____________|
   Skin                                    | +                 +  +  +                       +  +  +  +  +     +      |  22        |
      Inflammation, Acute                  |                                                                          |      1  2.0|
      Necrosis                             | 1                       2                             2                  |      3  1.7|
      Prepuce, Hemorrhage                  |                                                                          |      1  2.0|
      Prepuce, Inflammation, Acute         |                                                             2            |      2  1.5|
      Prepuce, Inflammation, Chronic Active|                                                                   3      |      1  3.0|
      Prepuce, Necrosis                    |                                                             2     2      |      2  2.0|
      Subcutaneous Tissue, Necrosis        |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +     +  +        +  +  +        +  +  +  +  +  +  +  +         |  31        |
      Joint, Hyperostosis                  |    3                                                                     |      2  2.5|
      Tarsal, Hyperostosis                 | 3  4  2  3        4        3  2  4        4  1  1     1     3            |     21  2.7|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |                                                    +  +  +               |   9        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |    +                                            +  +  +  +        +      |  17        |
      Congestion                           |                                                                          |      1  2.0|
      Hemorrhage                           |    2                                                                     |      1  2.0|
      Infiltration Cellular, Histiocyte    |                                                 1                        |      3  1.3|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    |                                                    +  +  M               |   7        |
                                            __________________________________________________________________________|____________|
   Trachea                                 |    +                                            +  +  +  +        +      |  17        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                            +                                             |   3        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |                               +                    +  +  +        +      |  13        |
      Casts Protein                        |                                                                          |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  38                                                               
NTP Experiment-Test: 05023-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                    PENTAERYTHRITOL TETRANITRATE                               Date: 05/01/97  
Route: DOSED FEED                                                                                                 Time: 13:22:26  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 6| 2| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 5| 0| 6| 3| 3| 3| 3| 3|            |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 5| 0| 9| 1| 1| 1| 1| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
    2.5%                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Cortex, Mineralization               |                                                          1               |      3  1.3|
      Papilla, Mineralization              |                                                                          |      1  1.0|
      Renal Tubule, Regeneration           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |    +              +                 +              +  +  +               |  15        |
      Calculus Gross Observation           |                   X                 X                                    |      4     |
      Calculus Micro Observation Only      |                   X                 X                                    |      5     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  39                                                               
NTP Experiment-Test: 05023-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                    PENTAERYTHRITOL TETRANITRATE                               Date: 05/01/97  
Route: DOSED FEED                                                                                                 Time: 13:22:26  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 0| 7| 7| 7| 6|             
                             DAY ON TEST   | 2| 2| 5| 1| 9| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| 3| 3| 3| 3| 2| 3| 3| 3| 3| 9|             
                                           | 9| 9| 2| 4| 2| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 9| 0| 0| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    5.0%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Anus, Necrosis                       |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Lymphoid Nodule, Hyperplasia         |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Lymphoid Nodule, Hyperplasia         |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Clear Cell Focus                     |                                                                          |             
      Cyst                                 |                                                                          |             
      Fibrosis                             |                                                       1                  |             
      Mixed Cell Focus                     |                                                                          |             
      Necrosis                             | 1                                                              3         |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Fat, Mineralization                  |                                                                          |             
      Fat, Necrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Acinus, Atrophy                      |                                                                   1      |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +|             
      Hyperkeratosis                       |                   1  1                                                   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic Active         |                   1  1                    2                              |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Capsule, Hyperplasia                 | 1  1     1  1  1  2  2  1  1  2  2  2  1  1  1  1  1  1  1     1  1  1  1|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                                                                          |             
      Hyperplasia                          |    1                                               1                     |             
      Hypertrophy                          |                      1           2                 1           1     1   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Hyperplasia                          |          1                       1                             1         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  40                                                               
NTP Experiment-Test: 05023-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                    PENTAERYTHRITOL TETRANITRATE                               Date: 05/01/97  
Route: DOSED FEED                                                                                                 Time: 13:22:26  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 0| 7| 7| 7| 6|             
                             DAY ON TEST   | 2| 2| 5| 1| 9| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| 3| 3| 3| 3| 2| 3| 3| 3| 3| 9|             
                                           | 9| 9| 2| 4| 2| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 9| 0| 0| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    5.0%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  M  +  +  M  +  +  +  M  M  +  +  +  +  M  +  +  M  +  M  +  M  M  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |                               X     X     X                          X   |             
      Pars Intermedia, Hyperplasia         |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +              +        +  +        +                 +           +     +|             
      Atrophy                              |                2                                                         |             
      Dilatation                           |                            3        3                             3     2|             
      Inflammation, Acute                  | 3                                                                        |             
      Inflammation, Chronic Active         |                1                                                         |             
      Necrosis                             |                                     3                                    |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                         2|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Seminiferous Tubule, Atrophy         |                                                       1                  |             
      Seminiferous Tubule, Mineralization  |                            1                                             |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  M  M  M  M  +  M  +  +  +  +  +  +  M  +  M  M  +  M  M  +  M  +  +|             
      Hematopoietic Cell Proliferation     |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Angiectasis                          |    2     2  2  2     3     1  3  1  2        2     2  3        1     3  3|             
      Hematopoietic Cell Proliferation     |    2     1  2  1     2        2     2        2     2  1        2     1  3|             
      Hemorrhage                           |                                  1                                       |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Depletion Lymphoid                   |                                                                         3|             
      Fibrosis                             |                                                          2               |             
      Hematopoietic Cell Proliferation     | 2  2     2  3  1     1  1  1  2  1  2     3  2  1        2     1  1      |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +|             
      Depletion Lymphoid                   |                                                                         3|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  +  +  M  M  M  M  +  M  +  M  M  M  M  +  M  +  M  M  M|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  41                                                               
NTP Experiment-Test: 05023-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                    PENTAERYTHRITOL TETRANITRATE                               Date: 05/01/97  
Route: DOSED FEED                                                                                                 Time: 13:22:26  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 0| 7| 7| 7| 6|             
                             DAY ON TEST   | 2| 2| 5| 1| 9| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| 3| 3| 3| 3| 2| 3| 3| 3| 3| 9|             
                                           | 9| 9| 2| 4| 2| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 9| 0| 0| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    5.0%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +|             
      Acanthosis                           |                                     2                                    |             
      Hyperkeratosis                       |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Mineralization                       |                                                                          |             
      Necrosis                             |             3                       1                                    |             
      Prepuce, Fibrosis                    |                                                                          |             
      Prepuce, Necrosis                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Tarsal, Hyperostosis                 | 2           2     2           3        2  3  2        2              3  1|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                                                2         |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           | 2                                                           3            |             
      Hemorrhage                           |                                                    1                     |             
      Infiltration Cellular, Histiocyte    |                                        2                                 |             
      Inflammation, Chronic Active         |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                            2                                             |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |          +                                                               |             
                                            __________________________________________________________________________|             
   Eye                                     |          +                                                               |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                       +  +               |             
      Hyperplasia                          |                                                          1               |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Casts Protein                        |                                  1                                       |             
      Congestion                           |                                  1                                       |             
      Inflammation, Acute                  |                                                                         3|             
      Cortex, Mineralization               |                         1                          1  1  1               |             
      Papilla, Mineralization              |                                                                          |             
      Papilla, Necrosis                    |                                                                         1|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Angiectasis                          |                2                                                         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  42                                                               
NTP Experiment-Test: 05023-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                    PENTAERYTHRITOL TETRANITRATE                               Date: 05/01/97  
Route: DOSED FEED                                                                                                 Time: 13:22:26  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 0| 7| 7| 7| 6|             
                             DAY ON TEST   | 2| 2| 5| 1| 9| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| 3| 3| 3| 3| 2| 3| 3| 3| 3| 9|             
                                           | 9| 9| 2| 4| 2| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 9| 0| 0| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    5.0%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Calculus Gross Observation           |                                                       X                  |             
      Calculus Micro Observation Only      |                                           X           X        X         |             
      Inflammation, Chronic Active         |                                                                         2|             
      Mineralization                       |                                                                         1|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  43                                                               
NTP Experiment-Test: 05023-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                    PENTAERYTHRITOL TETRANITRATE                               Date: 05/01/97  
Route: DOSED FEED                                                                                                 Time: 13:22:26  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 1| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 9| 6| 3| 3| 3| 3| 8| 3| 3| 3| 3| 8| 8| 3| 3| 3| 1|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 4| 4| 0| 0| 0| 0| 2| 0| 0| 0| 0| 2| 2| 0| 0| 0| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      A     |
    5.0%                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  47        |
      Anus, Necrosis                       |          2                                                               |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  M  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  47        |
      Lymphoid Nodule, Hyperplasia         |    3                 3                       3                           |      3  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  47        |
      Lymphoid Nodule, Hyperplasia         |    2                                         2                           |      2  2.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Clear Cell Focus                     |                               X                                          |      1     |
      Cyst                                 | X                                X                                       |      2     |
      Fibrosis                             |                                                                          |      1  1.0|
      Mixed Cell Focus                     |                                                 X                    X   |      2     |
      Necrosis                             |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                +                             +                           |   2        |
      Fat, Mineralization                  |                                              2                           |      1  2.0|
      Fat, Necrosis                        |                3                             3                           |      2  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  47        |
      Acinus, Atrophy                      |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  M  +  +  +  +  +  +  +  +|  46        |
      Hyperkeratosis                       |                                                                          |      2  1.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  47        |
      Hyperplasia                          |                                                                   1      |      1  1.0|
      Inflammation, Chronic Active         |                                              1        1     1            |      6  1.2|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|  48        |
      Capsule, Hyperplasia                 | 1     2  4  1     1  2  2  1  1  1  1  2     1  1  1  3  2  1  1  2  1  1|     45  1.4|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|  48        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  44                                                               
NTP Experiment-Test: 05023-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                    PENTAERYTHRITOL TETRANITRATE                               Date: 05/01/97  
Route: DOSED FEED                                                                                                 Time: 13:22:26  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 1| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 9| 6| 3| 3| 3| 3| 8| 3| 3| 3| 3| 8| 8| 3| 3| 3| 1|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 4| 4| 0| 0| 0| 0| 2| 0| 0| 0| 0| 2| 2| 0| 0| 0| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      A     |
    5.0%                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Accessory Adrenal Cortical Nodule    |                   X                                                      |      1     |
      Hyperplasia                          |       2              2                 2                                1|      6  1.5|
      Hypertrophy                          |       1  1  1           2     1  3                 1  3                  |     13  1.5|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|  47        |
      Hyperplasia                          |       1           1           1                                   1     1|      8  1.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  M  M  M  +  +  +  +  +  M  M  +  +  +  M  +  M  M  M  +  +  M  M  +  +|  27        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Pars Distalis, Cyst                  |                                                 X                        |      5     |
      Pars Intermedia, Hyperplasia         |          2                                                               |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  46        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |    +  +        +     +  +     +              +  +  +              +      |  18        |
      Atrophy                              |                                                                          |      1  2.0|
      Dilatation                           |                3     2                       3  3                 3      |      9  2.8|
      Inflammation, Acute                  |                                                                          |      1  3.0|
      Inflammation, Chronic Active         |                1                                   1                     |      3  1.0|
      Necrosis                             |    3  2                       2              1                           |      5  2.2|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  48        |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Seminiferous Tubule, Atrophy         |                                                                          |      1  1.0|
      Seminiferous Tubule, Mineralization  |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  M  +  +  +  +  M  M  M  +  M  A  M  M  M  +  +  +  +  M  M  +|  28        |
      Hematopoietic Cell Proliferation     |                1                                                         |      1  1.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  M|  45        |
      Angiectasis                          |       3  2     2           2  2              3        1           1  1   |     24  2.0|
      Hematopoietic Cell Proliferation     |    2  2        2           2  1              2                       1   |     20  1.8|
      Hemorrhage                           |                                                                          |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  45                                                               
NTP Experiment-Test: 05023-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                    PENTAERYTHRITOL TETRANITRATE                               Date: 05/01/97  
Route: DOSED FEED                                                                                                 Time: 13:22:26  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 1| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 9| 6| 3| 3| 3| 3| 8| 3| 3| 3| 3| 8| 8| 3| 3| 3| 1|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 4| 4| 0| 0| 0| 0| 2| 0| 0| 0| 0| 2| 2| 0| 0| 0| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      A     |
    5.0%                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  47        |
      Angiectasis                          |                                                          1               |      1  1.0|
      Depletion Lymphoid                   |                                                                          |      1  3.0|
      Fibrosis                             |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     | 1  2  2           3  1  1  2  2  2     1     2  2  2     1  2  2  1  2  3|     36  1.7|
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  M  +  +  +  +  +  M  +|  42        |
      Depletion Lymphoid                   |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  M  M  +  M  M  +  +  M  M  M  M  M  M  M  M  M  M  M  M  M  M|   9        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Acanthosis                           |                                                                          |      1  2.0|
      Hyperkeratosis                       |                                                                         2|      1  2.0|
      Inflammation, Acute                  |                                                                2         |      1  2.0|
      Mineralization                       |                                                                         3|      1  3.0|
      Necrosis                             |                   2     3                                                |      4  2.3|
      Prepuce, Fibrosis                    |                                                    2                     |      1  2.0|
      Prepuce, Necrosis                    |                                                    2                     |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Tarsal, Hyperostosis                 |    2  2  1  2     1  2  3  4  1              2        1     1  3  2     2|     25  2.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mineralization                       |                            2                 1                       2   |      4  1.8|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                                           2                             2|      4  2.3|
      Hemorrhage                           | 1                                            1           2               |      4  1.3|
      Infiltration Cellular, Histiocyte    | 3                                               2                        |      3  2.3|
      Inflammation, Chronic Active         |                                                                         2|      1  2.0|
      Alveolar Epithelium, Hyperplasia     |       2                                                        1         |      3  1.7|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  M|  48        |
      Inflammation, Acute                  |    1                                                                     |      1  1.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  46                                                               
NTP Experiment-Test: 05023-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                    PENTAERYTHRITOL TETRANITRATE                               Date: 05/01/97  
Route: DOSED FEED                                                                                                 Time: 13:22:26  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 1| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 9| 6| 3| 3| 3| 3| 8| 3| 3| 3| 3| 8| 8| 3| 3| 3| 1|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 4| 4| 0| 0| 0| 0| 2| 0| 0| 0| 0| 2| 2| 0| 0| 0| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      A     |
    5.0%                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                +                                         +  +            |   5        |
      Hyperplasia                          |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Casts Protein                        |                                                                          |      1  1.0|
      Congestion                           | 2                                                                        |      2  1.5|
      Inflammation, Acute                  |                                                                          |      1  3.0|
      Cortex, Mineralization               | 1                                   1     1                             1|      8  1.0|
      Papilla, Mineralization              |       1                                                                  |      1  1.0|
      Papilla, Necrosis                    |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  47        |
      Angiectasis                          |                                                                          |      1  2.0|
      Calculus Gross Observation           |                                     X                                    |      2     |
      Calculus Micro Observation Only      |                         X     X  X  X                          X         |      8     |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Mineralization                       |                                                                          |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  47                                                               
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