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TR 371 Mouse Pathology Tables


                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                              TOLUENE


NTP Experiment-Test: 05701-03                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 09/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:49:15




       Facility:  International Research and Development Corp.

       Chemical CAS #:  108883

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05701-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                              TOLUENE                                          Date: 09/18/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:49:15  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 PPM        120 PPM      600 PPM      1200 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          60           60           60           60                                     
  Scheduled Sacrifice                                 10           10           10           10                                     
  Early Deaths                                                                                                                      
    Dead                                              11            6           13            9                                     
    Moribund                                           8            8           11            3                                     
    Accident                                           1            3                         1                                     
    Natural Death                                                                2            2                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                30           33           23           32                                     
    Dead                                                                         1                                                  
  Missing                                                                                     3                                     
  Animals Examined Microscopically                    50           50           50           47                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (49)         (49)         (50)         (45)                                   
   Intestine Large, Cecum                             (49)         (50)         (50)         (47)                                   
      Histiocytic Sarcoma                                                        1 (2%)                                             
   Intestine Large, Rectum                            (50)         (50)         (50)         (45)                                   
   Intestine Small, Duodenum                          (49)         (50)         (50)         (47)                                   
   Intestine Small, Jejunum                           (49)         (50)         (50)         (47)                                   
   Liver                                              (49)         (50)         (50)         (47)                                   
      Hemangioma                                       1 (2%)                                                                       
      Hemangiosarcoma                                  1 (2%)                                                                       
      Hepatocellular Carcinoma                         4 (8%)       2 (4%)       2 (4%)       7 (15%)                               
      Hepatocellular Adenoma                           3 (6%)       7 (14%)      6 (12%)      7 (15%)                               
      Histiocytic Sarcoma                                                        1 (2%)       1 (2%)                                
   Mesentery                                          (5)          (2)          (4)          (2)                                    
      Hepatocellular Carcinoma, Metastatic, Liver                                             1 (50%)                               
      Osteosarcoma, Metastatic, Uncertain Primary                                                                                   
          Site                                                                                1 (50%)                               
   Pancreas                                           (50)         (50)         (50)         (47)                                   
   Salivary Glands                                    (50)         (50)         (50)         (46)                                   
   Stomach                                            (50)         (50)         (50)         (47)                                   
      Histiocytic Sarcoma                                                        1 (2%)                                             
   Stomach, Forestomach                               (50)         (49)         (50)         (47)                                   
      Squamous Cell Papilloma                          3 (6%)       1 (2%)       1 (2%)       3 (6%)                                
   Stomach, Glandular                                 (49)         (50)         (50)         (47)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   2                                                               
NTP Experiment-Test: 05701-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                              TOLUENE                                          Date: 09/18/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:49:15  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 PPM        120 PPM      600 PPM      1200 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (50)         (50)         (50)         (47)                                   
   Heart                                              (50)         (50)         (50)         (47)                                   
      Hemangiosarcoma                                                                         1 (2%)                                
      Hemangiosarcoma, Metastatic, Ovary                                                      1 (2%)                                
      Histiocytic Sarcoma                                                        1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (49)         (50)         (50)         (47)                                   
      Adenoma                                                                    1 (2%)       1 (2%)                                
   Adrenal Gland, Medulla                             (49)         (50)         (49)         (47)                                   
      Pheochromocytoma Malignant                                    1 (2%)                                                          
      Pheochromocytoma NOS                             1 (2%)       1 (2%)       1 (2%)       2 (4%)                                
   Pituitary Gland                                    (49)         (48)         (49)         (46)                                   
      Pars Distalis, Adenoma                          12 (24%)     19 (40%)     21 (43%)     15 (33%)                               
      Pars Intermedia, Adenoma                                      1 (2%)       1 (2%)       1 (2%)                                
   Thyroid Gland                                      (50)         (50)         (50)         (47)                                   
      Follicle, Adenocarcinoma                         1 (2%)                                                                       
      Follicle, Adenoma                                                          4 (8%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (50)         (49)         (50)         (47)                                   
      Granulosa Cell Tumor Benign                                   1 (2%)                                                          
      Hemangioma                                       1 (2%)                                 1 (2%)                                
      Hemangiosarcoma                                                                         1 (2%)                                
      Hemangiosarcoma, Metastatic                                                             1 (2%)                                
      Histiocytic Sarcoma                                                                     1 (2%)                                
      Luteoma                                          1 (2%)                                                                       
   Uterus                                             (50)         (50)         (50)         (47)                                   
      Adenocarcinoma                                                1 (2%)                                                          
      Hemangiosarcoma                                               1 (2%)                    1 (2%)                                
      Histiocytic Sarcoma                                                                     1 (2%)                                
      Leiomyoma                                                     1 (2%)                                                          
      Endometrium, Polyp Stromal                       3 (6%)       2 (4%)       1 (2%)       2 (4%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   3                                                               
NTP Experiment-Test: 05701-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                              TOLUENE                                          Date: 09/18/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:49:15  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 PPM        120 PPM      600 PPM      1200 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Blood                                              (1)          (1)          (1)                                                 
   Bone Marrow                                        (50)         (50)         (50)         (47)                                   
      Hemangioma                                                    1 (2%)                                                          
      Hemangiosarcoma, Metastatic, Ovary                                                      1 (2%)                                
      Hemangiosarcoma, Metastatic, Skin                                          1 (2%)                                             
      Hemangiosarcoma, Metastatic, Spleen                                                     1 (2%)                                
   Lymph Node                                         (48)         (49)         (50)         (46)                                   
      Adenocarcinoma, Metastatic, Uterus                            1 (2%)                                                          
      Iliac, Histiocytic Sarcoma                                                 1 (2%)       1 (2%)                                
      Mesenteric, Histiocytic Sarcoma                                            2 (4%)                                             
      Mesenteric, Osteosarcoma, Metastatic,                                                                                         
          Uncertain Primary Site                                                              1 (2%)                                
      Renal, Histiocytic Sarcoma                                                 2 (4%)                                             
   Lymph Node, Mandibular                             (47)         (48)         (50)         (43)                                   
      Histiocytic Sarcoma                                                        1 (2%)                                             
   Spleen                                             (50)         (50)         (49)         (47)                                   
      Adenocarcinoma, Metastatic, Uterus                            1 (2%)                                                          
      Hemangiosarcoma                                  1 (2%)       1 (2%)                    2 (4%)                                
      Hemangiosarcoma, Metastatic, Uterus                                                     1 (2%)                                
      Histiocytic Sarcoma                                                        2 (4%)       1 (2%)                                
   Thymus                                             (46)         (48)         (48)         (47)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (49)         (50)         (48)         (46)                                   
      Adenoacanthoma                                                1 (2%)                                                          
      Adenocarcinoma                                   2 (4%)                    2 (4%)                                             
      Carcinoma                                                                               1 (2%)                                
   Skin                                               (50)         (50)         (50)         (47)                                   
      Squamous Cell Papilloma                                                                 1 (2%)                                
      Subcutaneous Tissue, Fibrosarcoma                                          2 (4%)       1 (2%)                                
      Subcutaneous Tissue, Hemangioma                                                         1 (2%)                                
      Subcutaneous Tissue, Hemangiosarcoma                                       1 (2%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                                 (1)          (2)                                                 
      Head, Sarcoma, Deep Invasion                                  1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   4                                                               
NTP Experiment-Test: 05701-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                              TOLUENE                                          Date: 09/18/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:49:15  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 PPM        120 PPM      600 PPM      1200 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (47)                                   
      Meninges, Sarcoma, Metastatic                                 1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (47)                                   
      Alveolar/Bronchiolar Adenoma                     5 (10%)                   3 (6%)       4 (9%)                                
      Alveolar/Bronchiolar Carcinoma                                3 (6%)       1 (2%)       3 (6%)                                
      Carcinoma, Metastatic                                                                   1 (2%)                                
      Hepatocellular Carcinoma, Metastatic, Liver      1 (2%)                                 2 (4%)                                
      Histiocytic Sarcoma                                                        1 (2%)       1 (2%)                                
      Osteosarcoma, Metastatic, Uncertain Primary                                                                                   
          Site                                                                                1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                                 (3)          (2)          (3)                                    
      Adenoma                                                       2 (67%)      1 (50%)      1 (33%)                               
      Carcinoma                                                                               1 (33%)                               
      Bilateral, Adenocarcinoma                                                  1 (50%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (47)                                   
      Histiocytic Sarcoma                                                        1 (2%)       1 (2%)                                
      Osteosarcoma, Metastatic, Uncertain Primary                                                                                   
          Site                                                                                1 (2%)                                
   Urinary Bladder                                    (50)         (50)         (50)         (47)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)        *(47)                                   
      Histiocytic Sarcoma                                                        2 (4%)       1 (2%)                                
      Leukemia                                                      1 (2%)                                                          
      Lymphoma Malignant                                                         1 (2%)                                             
      Lymphoma Malignant Histiocytic                   2 (4%)                    1 (2%)       1 (2%)                                
      Lymphoma Malignant Lymphocytic                   2 (4%)       1 (2%)                    2 (4%)                                
      Lymphoma Malignant Mixed                        20 (40%)     10 (20%)     13 (26%)      6 (13%)                               
      Lymphoma Malignant Undifferentiated Cell                                   3 (6%)       2 (4%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   5                                                               
NTP Experiment-Test: 05701-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                              TOLUENE                                          Date: 09/18/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:49:15  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 PPM        120 PPM      600 PPM      1200 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            33          36          42          38                                       
     Total Primary Neoplasms                           63          59          69          70                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 19          28          29          29                                       
     Total Benign Neoplasms                            29          35          39          37                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              26          17          27          26                                       
     Total Malignant Neoplasms                         33          23          29          31                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              1           2           1           8                                       
     Total Metastatic Neoplasm                          1           3           1          13                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                   1                                       
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                  1           1           1           2                                       
     Total Uncertain Neoplasms                          1           1           1           2                                       
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   6                                                               
NTP Experiment-Test: 05701-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                              TOLUENE                                          Date: 09/18/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:49:15  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 PPM        120 PPM      600 PPM      1200 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          60           60           60           60                                     
  Early Deaths                                                                                                                      
    Moribund                                          19           18           23           17                                     
    Dead                                              23           19           16           21                                     
    Accident                                           1                         2            2                                     
    Natural Death                                                   1            3            1                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                17           21           16           19                                     
    Dead                                                            1                                                               
  Animals Examined Microscopically                    60           60           60           60                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (59)         (54)         (57)         (59)                                   
   Intestine Large, Cecum                             (60)         (60)         (60)         (59)                                   
   Intestine Large, Colon                             (60)         (60)         (60)         (59)                                   
   Intestine Small, Jejunum                           (60)         (60)         (60)         (60)                                   
   Liver                                              (60)         (60)         (60)         (59)                                   
      Hemangioma                                                                 1 (2%)                                             
      Hemangiosarcoma                                  2 (3%)                                 1 (2%)                                
      Hemangiosarcoma, Metastatic, Spleen                                                     1 (2%)                                
      Hepatocellular Carcinoma                        13 (22%)      8 (13%)      9 (15%)      8 (14%)                               
      Hepatocellular Adenoma                           7 (12%)     10 (17%)      9 (15%)     10 (17%)                               
      Hepatocellular Adenoma, Multiple                                                        1 (2%)                                
      Histiocytic Sarcoma                                                                     1 (2%)                                
      Ito Cell Tumor Malignant                                                                1 (2%)                                
   Mesentery                                          (2)                       (2)          (1)                                    
   Pancreas                                           (60)         (60)         (60)         (59)                                   
   Salivary Glands                                    (60)         (60)         (60)         (59)                                   
   Stomach, Forestomach                               (60)         (59)         (60)         (60)                                   
      Squamous Cell Papilloma                          1 (2%)       1 (2%)       1 (2%)                                             
   Stomach, Glandular                                 (60)         (60)         (60)         (60)                                   
   Tooth                                              (2)          (8)          (2)          (1)                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (60)         (60)         (60)         (59)                                   
      Hemangiosarcoma                                                                         1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   7                                                               
NTP Experiment-Test: 05701-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                              TOLUENE                                          Date: 09/18/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:49:15  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 PPM        120 PPM      600 PPM      1200 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (60)         (60)         (59)         (60)                                   
      Capsule, Spindle Cell, Adenoma                   1 (2%)                                                                       
   Adrenal Gland, Cortex                              (60)         (60)         (59)         (59)                                   
      Adenoma                                                                    1 (2%)                                             
   Islets, Pancreatic                                 (60)         (60)         (60)         (58)                                   
      Adenoma                                                                    1 (2%)       1 (2%)                                
   Pituitary Gland                                    (59)         (58)         (58)         (56)                                   
      Pars Distalis, Adenoma                                        2 (3%)       1 (2%)                                             
      Pars Intermedia, Adenoma                                                                1 (2%)                                
   Thyroid Gland                                      (60)         (60)         (60)         (59)                                   
      Follicle, Adenoma                                1 (2%)       2 (3%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (60)         (60)         (60)         (60)                                   
   Preputial Gland                                    (12)         (9)          (10)         (11)                                   
   Prostate                                           (60)         (60)         (59)         (59)                                   
   Seminal Vesicle                                    (4)          (4)          (4)          (6)                                    
   Testes                                             (60)         (60)         (60)         (60)                                   
      Interstitial Cell, Adenoma                                    1 (2%)                    1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (60)         (60)         (60)         (59)                                   
      Hemangiosarcoma, Metastatic, Liver               1 (2%)                                                                       
      Hemangiosarcoma, Metastatic, Spleen                                                     1 (2%)                                
   Lymph Node                                         (60)         (60)         (59)         (59)                                   
      Hepatocellular Carcinoma, Metastatic, Liver                                1 (2%)                                             
      Histiocytic Sarcoma                              1 (2%)                                                                       
      Mediastinal, Histiocytic Sarcoma                                                        1 (2%)                                
      Mesenteric, Hemangiosarcoma, Metastatic,                                                                                      
           Liver                                       1 (2%)                                                                       
      Mesenteric, Histiocytic Sarcoma                                                         1 (2%)                                
      Renal, Histiocytic Sarcoma                                                              1 (2%)                                
   Lymph Node, Mandibular                             (53)         (52)         (54)         (51)                                   
   Spleen                                             (60)         (60)         (60)         (59)                                   
      Hemangiosarcoma                                                            1 (2%)       3 (5%)                                
      Histiocytic Sarcoma                                                                     1 (2%)                                
   Thymus                                             (53)         (59)         (58)         (54)                                   
                                                             Page   8                                                               
NTP Experiment-Test: 05701-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                              TOLUENE                                          Date: 09/18/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:49:15  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 PPM        120 PPM      600 PPM      1200 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - cont                                                                                                         
      Histiocytic Sarcoma                              1 (2%)                                 1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (60)         (60)         (60)         (58)                                   
      Neck, Subcutaneous Tissue, Hemangioma                         1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (60)         (60)         (60)         (60)                                   
      Hemangiosarcoma, Metastatic, Spleen                                                     1 (2%)                                
   Skeletal Muscle                                                 (2)          (6)          (3)                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (60)         (60)         (60)         (60)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (60)         (60)         (60)                                   
      Adenocarcinoma, Metastatic, Harderian Gland                                1 (2%)                                             
      Alveolar/Bronchiolar Adenoma                     8 (13%)      1 (2%)       2 (3%)       7 (12%)                               
      Alveolar/Bronchiolar Adenoma, Multiple                                                  1 (2%)                                
      Alveolar/Bronchiolar Carcinoma                   2 (3%)       1 (2%)                    1 (2%)                                
      Hepatocellular Carcinoma, Metastatic, Liver      3 (5%)                    1 (2%)       1 (2%)                                
      Histiocytic Sarcoma                                                                     1 (2%)                                
   Nose                                               (59)         (59)         (60)         (59)                                   
      Adenocarcinoma, Metastatic, Harderian Gland                                1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                                 (3)          (1)          (3)                                    
      Adenocarcinoma                                                             1 (100%)                                           
      Adenoma                                                       3 (100%)                  2 (67%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (60)         (60)         (59)                                   
      Hepatocellular Carcinoma, Metastatic, Liver                                1 (2%)                                             
      Lipoma                                                        1 (2%)                                                          
   Urinary Bladder                                    (60)         (60)         (60)         (59)                                   
                                                             Page   9                                                               
NTP Experiment-Test: 05701-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                              TOLUENE                                          Date: 09/18/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:49:15  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 PPM        120 PPM      600 PPM      1200 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(60)        *(60)        *(60)        *(60)                                   
      Histiocytic Sarcoma                              1 (2%)                                 1 (2%)                                
      Lymphoma Malignant Histiocytic                                3 (5%)                                                          
      Lymphoma Malignant Lymphocytic                                             2 (3%)                                             
      Lymphoma Malignant Mixed                         5 (8%)       7 (12%)      6 (10%)      3 (5%)                                
      Lymphoma Malignant Undifferentiated Cell                                                1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  10                                                               
NTP Experiment-Test: 05701-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                              TOLUENE                                          Date: 09/18/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:49:15  
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         B6C3F1 MICE MALE                          0 PPM        120 PPM      600 PPM      1200 PPM                                  
                                                                                                                                    
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TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            29          29          26          33                                       
     Total Primary Neoplasms                           41          41          35          44                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 16          18          14          19                                       
     Total Benign Neoplasms                            18          22          16          24                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              20          16          17          17                                       
     Total Malignant Neoplasms                         23          19          19          20                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              4                       3           2                                       
     Total Metastatic Neoplasm                          5                       5           4                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
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a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
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