National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/5086

TR 371 Rat Pathology Tables


                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                                              TOLUENE


NTP Experiment-Test: 05701-02                                                                                     Report: PEIRPT03
Study Type: CHRONIC                                                                                               Date: 09/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:13:18




       Facility:  International Research and Development Corp.

       Chemical CAS #:  108883

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05701-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                              TOLUENE                                          Date: 09/18/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:13:18  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0 PPM        600 PPM      1200 PPM                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          60           60           60                                                  
  Scheduled Sacrifice                                 10           10           10                                                  
  Early Deaths                                                                                                                      
    Dead                                               6            7            6                                                  
    Moribund                                          11            8           14                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                32           35           30                                                  
    Dead                                               1                                                                            
  Animals Examined Microscopically                    50           50           50                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (49)         (50)         (49)                                                
      Inflammation, Chronic                                         1 (2%)                                                          
   Intestine Large, Cecum                             (50)         (49)         (49)                                                
      Inflammation, Acute                              1 (2%)       2 (4%)                                                          
   Intestine Large, Colon                             (50)         (49)         (49)                                                
      Inflammation, Acute                                           1 (2%)                                                          
      Parasite Metazoan                                5 (10%)      1 (2%)       2 (4%)                                             
   Intestine Large, Rectum                            (50)         (50)         (48)                                                
      Parasite Metazoan                                4 (8%)       5 (10%)                                                         
      Ulcer                                                         1 (2%)       1 (2%)                                             
   Intestine Small, Duodenum                          (50)         (49)         (49)                                                
      Edema                                                         1 (2%)                                                          
      Erosion                                          1 (2%)       1 (2%)       1 (2%)                                             
   Intestine Small, Ileum                             (50)         (49)         (49)                                                
      Edema                                                         1 (2%)                                                          
      Ulcer                                                         1 (2%)                                                          
   Intestine Small, Jejunum                           (50)         (49)         (49)                                                
      Edema                                                         1 (2%)                                                          
   Liver                                              (50)         (50)         (50)                                                
      Angiectasis                                      2 (4%)       6 (12%)      6 (12%)                                            
      Congestion                                                    1 (2%)                                                          
      Developmental Malformation                       6 (12%)      5 (10%)      5 (10%)                                            
      Fatty Change                                     3 (6%)       3 (6%)       2 (4%)                                             
      Focal Cellular Change                           29 (58%)     41 (82%)     41 (82%)                                            
      Granuloma                                       12 (24%)     13 (26%)     10 (20%)                                            
      Hematopoietic Cell Proliferation                 1 (2%)       2 (4%)       2 (4%)                                             
      Hemorrhage                                                    1 (2%)       1 (2%)                                             
      Necrosis                                         4 (8%)       1 (2%)                                                          
      Arteriole, Thrombosis                            1 (2%)                                                                       
      Bile Duct, Hyperplasia                          38 (76%)     36 (72%)     31 (62%)                                            
      Portal, Hyperplasia                                                        1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05701-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                              TOLUENE                                          Date: 09/18/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:13:18  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0 PPM        600 PPM      1200 PPM                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Portal, Inflammation, Chronic                   47 (94%)     46 (92%)     40 (80%)                                            
      Portal, Inflammation, Chronic Active                                       1 (2%)                                             
      Venule, Thrombosis                               1 (2%)                                                                       
   Mesentery                                          (1)          (1)          (2)                                                 
      Fat, Necrosis                                    1 (100%)     1 (100%)     1 (50%)                                            
   Pancreas                                           (50)         (49)         (50)                                                
      Infiltration Cellular, Lymphocyte                                          1 (2%)                                             
      Inflammation, Chronic Active                                               1 (2%)                                             
      Acinus, Atrophy                                 18 (36%)     24 (49%)     15 (30%)                                            
      Acinus, Hyperplasia                              1 (2%)       4 (8%)                                                          
      Acinus, Vacuolization Cytoplasmic                                          1 (2%)                                             
      Arteriole, Inflammation, Chronic                                           1 (2%)                                             
      Duct, Ectasia                                    1 (2%)                                                                       
   Salivary Glands                                    (50)         (50)         (50)                                                
      Infiltration Cellular, Lymphocyte                                          1 (2%)                                             
      Acinus, Atrophy                                                            1 (2%)                                             
   Stomach, Forestomach                               (50)         (50)         (50)                                                
      Hyperkeratosis                                                1 (2%)                                                          
      Hyperplasia, Squamous                            1 (2%)       2 (4%)       4 (8%)                                             
      Inflammation, Acute                                           3 (6%)                                                          
      Inflammation, Chronic Active                     2 (4%)       1 (2%)       3 (6%)                                             
      Ulcer                                            6 (12%)      5 (10%)      9 (18%)                                            
   Stomach, Glandular                                 (50)         (50)         (50)                                                
      Foreign Body                                                               1 (2%)                                             
      Inflammation, Acute                                           1 (2%)       1 (2%)                                             
      Inflammation, Chronic Active                                               2 (4%)                                             
      Mucosa, Dilatation                              27 (54%)     26 (52%)     28 (56%)                                            
      Mucosa, Erosion                                  6 (12%)      4 (8%)       5 (10%)                                            
      Mucosa, Mineralization                                                     1 (2%)                                             
      Mucosa, Pigmentation                             1 (2%)                                                                       
      Mucosa, Ulcer                                    2 (4%)                                                                       
      Serosa, Inflammation, Chronic Active                                       1 (2%)                                             
   Tooth                                                           (1)          (2)                                                 
      Peridontal Tissue, Inflammation, Chronic                                   1 (50%)                                            
      Pulp, Inflammation, Chronic                                                1 (50%)                                            
      Pulp, Inflammation, Chronic Active                            1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (50)         (50)         (50)                                                
      Aorta, Mineralization                                                      1 (2%)                                             
   Heart                                              (50)         (50)         (50)                                                
      Cardiomyopathy, Chronic                         48 (96%)     50 (100%)    47 (94%)                                            
      Inflammation, Acute                              1 (2%)                                                                       
      Mineralization                                   1 (2%)                    1 (2%)                                             
      Artery, Mineralization                                                     1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05701-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                              TOLUENE                                          Date: 09/18/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:13:18  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0 PPM        600 PPM      1200 PPM                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
CARDIOVASCULAR SYSTEM - CONT                                                                                                        
      Atrium, Thrombosis                               2 (4%)       1 (2%)       1 (2%)                                             
      Ventricle, Thrombosis                            1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (49)         (49)                                                
      Congestion                                                                 1 (2%)                                             
      Degeneration, Fatty                             33 (66%)     31 (63%)     37 (76%)                                            
      Hematopoietic Cell Proliferation                              1 (2%)                                                          
      Hemorrhage                                                    1 (2%)                                                          
      Hyperplasia                                     16 (32%)     19 (39%)      9 (18%)                                            
      Hypertrophy                                      4 (8%)       9 (18%)      4 (8%)                                             
      Inflammation, Chronic                                                      1 (2%)                                             
      Pigmentation                                    50 (100%)    48 (98%)     48 (98%)                                            
   Adrenal Gland, Medulla                             (49)         (48)         (49)                                                
      Hematopoietic Cell Proliferation                                           1 (2%)                                             
      Hyperplasia                                      4 (8%)       4 (8%)       6 (12%)                                            
   Islets, Pancreatic                                 (50)         (49)         (50)                                                
      Hyperplasia                                      1 (2%)       1 (2%)                                                          
   Parathyroid Gland                                  (42)         (44)         (41)                                                
      Hypertrophy                                                                1 (2%)                                             
   Pituitary Gland                                    (50)         (50)         (50)                                                
      Pars Distalis, Angiectasis                       1 (2%)       3 (6%)       1 (2%)                                             
      Pars Distalis, Congestion                                                  1 (2%)                                             
      Pars Distalis, Cyst                             10 (20%)     14 (28%)     11 (22%)                                            
      Pars Distalis, Hemorrhage                        3 (6%)                    1 (2%)                                             
      Pars Distalis, Hyperplasia                       7 (14%)     17 (34%)      7 (14%)                                            
      Pars Distalis, Metaplasia, Osseous                            1 (2%)                                                          
      Pars Intermedia, Angiectasis                     1 (2%)       2 (4%)       2 (4%)                                             
      Pars Intermedia, Cyst                            1 (2%)                                                                       
      Pars Nervosa, Cyst                                            1 (2%)                                                          
   Thyroid Gland                                      (50)         (50)         (50)                                                
      Hemorrhage                                       1 (2%)                                                                       
      Inflammation, Acute                              1 (2%)                                                                       
      Ultimobranchial Cyst                                          1 (2%)       2 (4%)                                             
      C-Cell, Hyperplasia                             17 (34%)     23 (46%)     15 (30%)                                            
      Follicle, Ectasia                                             4 (8%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05701-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                              TOLUENE                                          Date: 09/18/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:13:18  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0 PPM        600 PPM      1200 PPM                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (49)         (50)         (44)                                                
      Cyst                                             1 (2%)                                                                       
      Hyperplasia                                                   2 (4%)       2 (5%)                                             
      Inflammation, Acute                              1 (2%)                    2 (5%)                                             
      Inflammation, Chronic                           21 (43%)     20 (40%)     21 (48%)                                            
      Inflammation, Chronic Active                    10 (20%)     14 (28%)      7 (16%)                                            
      Duct, Ectasia                                    2 (4%)                    1 (2%)                                             
      Duct, Hyperplasia, Squamous                                                1 (2%)                                             
   Ovary                                              (50)         (50)         (50)                                                
      Follicle, Cyst                                                             1 (2%)                                             
      Periovarian Tissue, Cyst                         2 (4%)       1 (2%)       2 (4%)                                             
   Uterus                                             (50)         (50)         (50)                                                
      Ectasia                                          2 (4%)       1 (2%)       1 (2%)                                             
      Hemorrhage                                       1 (2%)                                                                       
      Prolapse                                         1 (2%)                                                                       
      Endometrium, Ectasia                                                       1 (2%)                                             
      Endometrium, Hyperplasia, Cystic                 2 (4%)       2 (4%)       7 (14%)                                            
      Endometrium, Inflammation, Chronic                            1 (2%)       1 (2%)                                             
      Myometrium, Inflammation, Chronic                                          1 (2%)                                             
   Vagina                                             (4)          (4)          (3)                                                 
      Inflammation, Acute                                                        1 (33%)                                            
      Inflammation, Chronic Active                     1 (25%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (49)         (50)         (50)                                                
      Hyperplasia                                                                1 (2%)                                             
      Myelofibrosis                                    8 (16%)      9 (18%)      4 (8%)                                             
      Myeloid Cell, Hyperplasia                        1 (2%)                                                                       
   Lymph Node                                         (50)         (50)         (50)                                                
      Congestion                                       1 (2%)       1 (2%)       1 (2%)                                             
      Hyperplasia, Lymphoid                            6 (12%)      3 (6%)      10 (20%)                                            
      Inflammation, Acute                              1 (2%)                    1 (2%)                                             
      Pigmentation                                                  1 (2%)                                                          
      Mediastinal, Congestion                                       1 (2%)                                                          
      Mediastinal, Hemorrhage                          1 (2%)                                                                       
      Mediastinal, Hyperplasia, Lymphoid                            1 (2%)       2 (4%)                                             
      Mediastinal, Pigmentation                                                  1 (2%)                                             
      Mesenteric, Congestion                           4 (8%)       3 (6%)       4 (8%)                                             
      Mesenteric, Edema                                1 (2%)                                                                       
      Mesenteric, Hyperplasia, Lymphoid               17 (34%)     32 (64%)     29 (58%)                                            
      Mesenteric, Inflammation, Acute                  1 (2%)       1 (2%)                                                          
      Renal, Congestion                                             1 (2%)                                                          
   Lymph Node, Mandibular                             (47)         (48)         (42)                                                
      Congestion                                       5 (11%)      8 (17%)      3 (7%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05701-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                              TOLUENE                                          Date: 09/18/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:13:18  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0 PPM        600 PPM      1200 PPM                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Cyst                                             1 (2%)       1 (2%)       2 (5%)                                             
      Hyperplasia, Lymphoid                           41 (87%)     42 (88%)     39 (93%)                                            
      Inflammation, Acute                              1 (2%)                    1 (2%)                                             
   Spleen                                             (50)         (50)         (50)                                                
      Fibrosis                                                      3 (6%)       3 (6%)                                             
      Hematopoietic Cell Proliferation                41 (82%)     46 (92%)     44 (88%)                                            
      Hyperplasia, Lymphoid                            1 (2%)       1 (2%)       1 (2%)                                             
      Hyperplasia, Reticulum Cell                      1 (2%)                                                                       
      Infarct                                                       1 (2%)       1 (2%)                                             
      Pigmentation                                    44 (88%)     44 (88%)     47 (94%)                                            
      Capsule, Fibrosis                                             2 (4%)                                                          
      Capsule, Inflammation, Acute                                               1 (2%)                                             
   Thymus                                             (46)         (46)         (46)                                                
      Congestion                                       4 (9%)       2 (4%)       1 (2%)                                             
      Cyst                                             2 (4%)       2 (4%)       3 (7%)                                             
      Hyperplasia, Lymphoid                                         3 (7%)       1 (2%)                                             
      Mediastinum, Inflammation, Chronic Active        1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (50)         (50)                                                
      Inflammation, Acute                              1 (2%)                                                                       
      Inflammation, Chronic                                                      1 (2%)                                             
      Inflammation, Chronic Active                     1 (2%)                                                                       
      Acinus, Ectasia                                 37 (74%)     34 (68%)     27 (54%)                                            
      Acinus, Hyperplasia                              3 (6%)       1 (2%)                                                          
      Acinus, Hyperplasia, Cystic                                                1 (2%)                                             
      Duct, Ectasia                                   21 (42%)     31 (62%)     23 (46%)                                            
   Skin                                               (50)         (50)         (50)                                                
      Cyst Epithelial Inclusion                                                  1 (2%)                                             
      Head, Inflammation, Chronic Active               1 (2%)       1 (2%)                                                          
      Head, Ulcer                                                                1 (2%)                                             
      Lip, Inflammation, Chronic Active                             1 (2%)                                                          
      Subcutaneous Tissue, Abscess                                               1 (2%)                                             
      Subcutaneous Tissue, Head, Abscess                                         1 (2%)                                             
      Subcutaneous Tissue, Head, Granuloma                          1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (49)         (50)         (50)                                                
      Cranium, Fibrous Osteodystrophy                  1 (2%)                    2 (4%)                                             
      Cranium, Osteopetrosis                           2 (4%)       1 (2%)                                                          
      Femur, Fibrous Osteodystrophy                    1 (2%)                    4 (8%)                                             
      Femur, Osteopetrosis                             3 (6%)       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05701-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                              TOLUENE                                          Date: 09/18/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:13:18  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0 PPM        600 PPM      1200 PPM                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (49)                                                
      Compression                                     11 (22%)      6 (12%)     13 (27%)                                            
      Gliosis                                          1 (2%)                                                                       
      Hemorrhage                                       5 (10%)      6 (12%)      3 (6%)                                             
      Hydrocephalus                                    1 (2%)       2 (4%)                                                          
      Lateral Ventricle, Hemorrhage                    1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)                                                
      Congestion                                       5 (10%)      5 (10%)      6 (12%)                                            
      Hemorrhage                                       7 (14%)      7 (14%)      4 (8%)                                             
      Infiltration Cellular                                         1 (2%)                                                          
      Infiltration Cellular, Lymphocyte               49 (98%)     49 (98%)     50 (100%)                                           
      Metaplasia, Osseous                                           1 (2%)                                                          
      Pigmentation, Cholesterol                        1 (2%)                    2 (4%)                                             
      Alveolar Epithelium, Hyperplasia                              1 (2%)       2 (4%)                                             
      Alveolus, Infiltration Cellular, Histiocyte     28 (56%)     20 (40%)     36 (72%)                                            
      Alveolus, Mineralization                         1 (2%)                                                                       
      Arteriole, Mineralization                       25 (50%)     30 (60%)     26 (52%)                                            
      Interstitium, Inflammation, Chronic             17 (34%)      9 (18%)      2 (4%)                                             
      Interstitium, Inflammation, Chronic Active       1 (2%)       2 (4%)       4 (8%)                                             
      Peribronchiolar, Inflammation, Acute             2 (4%)       1 (2%)                                                          
      Peribronchiolar, Inflammation, Chronic                        5 (10%)      1 (2%)                                             
      Peribronchiolar, Inflammation, Chronic Active                              1 (2%)                                             
      Pleura, Fibrosis                                                           1 (2%)                                             
      Smooth Muscle, Hyperplasia                                                 1 (2%)                                             
   Nose                                               (49)         (50)         (50)                                                
      Glands, Hyperplasia                                                        1 (2%)                                             
      Lumen, Foreign Body                              4 (8%)       1 (2%)       1 (2%)                                             
      Lumen, Hemorrhage                               30 (61%)     34 (68%)     32 (64%)                                            
      Mucosa, Inflammation                                          1 (2%)                                                          
      Mucosa, Inflammation, Acute                     27 (55%)     41 (82%)     41 (82%)                                            
      Nasolacrimal Duct, Hemorrhage                    1 (2%)                                                                       
      Nasolacrimal Duct, Inflammation, Acute           5 (10%)      2 (4%)       6 (12%)                                            
      Nasolacrimal Duct, Inflammation, Chronic                                                                                      
          Active                                                    1 (2%)                                                          
      Olfactory Epithelium, Degeneration              44 (90%)     48 (96%)     47 (94%)                                            
      Olfactory Epithelium, Erosion                    2 (4%)      11 (22%)     10 (20%)                                            
      Olfactory Epithelium, Hemorrhage                                           1 (2%)                                             
      Olfactory Epithelium, Metaplasia                              1 (2%)       5 (10%)                                            
      Olfactory Epithelium, Metaplasia, Squamous                    1 (2%)       1 (2%)                                             
      Respiratory Epithelium, Degeneration            29 (59%)     45 (90%)     39 (78%)                                            
      Respiratory Epithelium, Erosion                  4 (8%)       1 (2%)       3 (6%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 05701-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                              TOLUENE                                          Date: 09/18/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:13:18  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0 PPM        600 PPM      1200 PPM                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Respiratory Epithelium, Metaplasia, Squamous     1 (2%)       1 (2%)                                                          
   Trachea                                            (50)         (50)         (50)                                                
      Hemorrhage                                       1 (2%)                                                                       
      Inflammation, Acute                              1 (2%)                                                                       
      Inflammation, Chronic Active                                  1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (5)          (4)          (3)                                                 
      Atrophy                                          1 (20%)      1 (25%)                                                         
      Cataract                                         3 (60%)      2 (50%)      2 (67%)                                            
      Hemorrhage                                                    1 (25%)                                                         
      Anterior Chamber, Hemorrhage                                               1 (33%)                                            
      Lids, Inflammation, Chronic Active                                         1 (33%)                                            
      Retina, Degeneration                             4 (80%)      3 (75%)      2 (67%)                                            
      Sclera, Mineralization                           2 (40%)      2 (50%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)                                                
      Hydronephrosis                                                             1 (2%)                                             
      Inflammation, Acute                              1 (2%)                                                                       
      Nephropathy, Chronic                            49 (98%)     48 (96%)     49 (98%)                                            
      Capsule, Inflammation, Chronic                                             1 (2%)                                             
      Pelvis, Calculus Micro Observation Only          1 (2%)       1 (2%)                                                          
      Renal Tubule, Cyst                               2 (4%)                    1 (2%)                                             
      Renal Tubule, Hyperplasia                        1 (2%)       1 (2%)                                                          
      Renal Tubule, Hypertrophy                                     1 (2%)                                                          
      Renal Tubule, Pigmentation                      49 (98%)     50 (100%)    48 (96%)                                            
   Urinary Bladder                                    (50)         (50)         (50)                                                
      Infiltration Cellular, Lymphocyte                1 (2%)                    1 (2%)                                             
      Inflammation, Chronic                            1 (2%)                    2 (4%)                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
NTP Experiment-Test: 05701-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                              TOLUENE                                          Date: 09/18/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:13:18  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0 PPM        600 PPM      1200 PPM                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          60           60           60                                                  
  Scheduled Sacrifice                                 10           10           10                                                  
  Early Deaths                                                                                                                      
    Moribund                                          14           11           23                                                  
    Dead                                               6            8            5                                                  
    Natural Death                                                   3                                                               
  Survivors                                                                                                                         
    Terminal Sacrifice                                29           27           22                                                  
    Dead                                                            1                                                               
    Accident                                           1                                                                            
  Animals Examined Microscopically                    50           50           50                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (50)         (50)         (49)                                                
      Erosion                                                       1 (2%)                                                          
      Hemorrhage                                                    2 (4%)                                                          
      Inflammation, Acute                              1 (2%)                                                                       
   Intestine Large, Colon                             (50)         (50)         (49)                                                
      Granuloma                                                                  1 (2%)                                             
      Parasite Metazoan                                2 (4%)       4 (8%)       1 (2%)                                             
   Intestine Large, Rectum                            (49)         (50)         (49)                                                
      Erosion                                                       1 (2%)                                                          
      Inflammation, Acute                                                        1 (2%)                                             
      Parasite Metazoan                                2 (4%)       4 (8%)       7 (14%)                                            
      Ulcer                                                         4 (8%)       3 (6%)                                             
   Intestine Small, Duodenum                          (50)         (50)         (49)                                                
      Erosion                                                                    1 (2%)                                             
      Ulcer                                            1 (2%)                                                                       
   Intestine Small, Ileum                             (49)         (50)         (49)                                                
      Erosion                                                                    1 (2%)                                             
   Liver                                              (50)         (50)         (50)                                                
      Angiectasis                                      7 (14%)     11 (22%)      3 (6%)                                             
      Congestion                                       3 (6%)       2 (4%)       1 (2%)                                             
      Developmental Malformation                       1 (2%)       4 (8%)       2 (4%)                                             
      Fatty Change                                     3 (6%)       2 (4%)       8 (16%)                                            
      Focal Cellular Change                           28 (56%)     23 (46%)     23 (46%)                                            
      Granuloma                                        1 (2%)       1 (2%)       1 (2%)                                             
      Hematopoietic Cell Proliferation                              2 (4%)                                                          
      Hemorrhage                                                    2 (4%)                                                          
      Necrosis                                         2 (4%)       2 (4%)       1 (2%)                                             
      Bile Duct, Dilatation                                         1 (2%)                                                          
      Bile Duct, Hyperplasia                          48 (96%)     49 (98%)     49 (98%)                                            
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    9                                                              
NTP Experiment-Test: 05701-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                              TOLUENE                                          Date: 09/18/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:13:18  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0 PPM        600 PPM      1200 PPM                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Bile Duct, Inflammation, Chronic                              1 (2%)                                                          
      Portal, Inflammation, Chronic                   48 (96%)     45 (90%)     46 (92%)                                            
      Serosa, Fibrosis                                                           1 (2%)                                             
   Mesentery                                          (2)          (2)          (4)                                                 
      Inflammation, Acute                                           1 (50%)                                                         
      Arteriole, Inflammation, Chronic                                           2 (50%)                                            
      Arteriole, Inflammation, Chronic Active                                    1 (25%)                                            
      Fat, Necrosis                                    2 (100%)                  1 (25%)                                            
   Pancreas                                           (50)         (50)         (50)                                                
      Inflammation, Acute                                           1 (2%)                                                          
      Acinus, Atrophy                                 30 (60%)     34 (68%)     30 (60%)                                            
      Acinus, Hyperplasia                              1 (2%)       4 (8%)       1 (2%)                                             
      Arteriole, Inflammation, Chronic Active                                    1 (2%)                                             
      Arteriole, Mineralization                                                  1 (2%)                                             
      Artery, Inflammation, Chronic                    1 (2%)                                                                       
   Salivary Glands                                    (50)         (50)         (50)                                                
      Infiltration Cellular, Lymphocyte                1 (2%)       1 (2%)                                                          
      Inflammation, Chronic                                         1 (2%)                                                          
      Acinus, Atrophy                                               1 (2%)       1 (2%)                                             
      Arteriole, Mineralization                                                  1 (2%)                                             
   Stomach                                            (50)         (50)         (50)                                                
      Ulcer                                                                      1 (2%)                                             
   Stomach, Forestomach                               (50)         (50)         (49)                                                
      Cyst                                             1 (2%)                                                                       
      Erosion                                          1 (2%)       1 (2%)       1 (2%)                                             
      Hyperplasia, Squamous                            2 (4%)       1 (2%)       2 (4%)                                             
      Inflammation, Acute                              4 (8%)       3 (6%)       2 (4%)                                             
      Inflammation, Chronic                                         1 (2%)                                                          
      Inflammation, Chronic Active                     3 (6%)       2 (4%)       2 (4%)                                             
      Mineralization                                                             1 (2%)                                             
      Ulcer                                            4 (8%)       7 (14%)      9 (18%)                                            
   Stomach, Glandular                                 (50)         (50)         (49)                                                
      Inflammation, Acute                              1 (2%)                                                                       
      Inflammation, Chronic Active                                               1 (2%)                                             
      Mineralization                                                             2 (4%)                                             
      Mucosa, Congestion                                            1 (2%)                                                          
      Mucosa, Dilatation                              17 (34%)     21 (42%)     18 (37%)                                            
      Mucosa, Ectasia                                  2 (4%)                                                                       
      Mucosa, Erosion                                  4 (8%)      11 (22%)      9 (18%)                                            
      Mucosa, Granuloma                                             1 (2%)                                                          
      Mucosa, Hemorrhage                                            1 (2%)                                                          
      Mucosa, Inflammation, Acute                                   1 (2%)                                                          
      Mucosa, Ulcer                                    2 (4%)       5 (10%)      3 (6%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   10                                                              
NTP Experiment-Test: 05701-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                              TOLUENE                                          Date: 09/18/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:13:18  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0 PPM        600 PPM      1200 PPM                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (50)         (50)         (50)                                                
      Aorta, Mineralization                                                      1 (2%)                                             
      Thoracic, Inflammation, Chronic Active                                     1 (2%)                                             
   Heart                                              (50)         (50)         (50)                                                
      Cardiomyopathy, Chronic                         49 (98%)     47 (94%)     47 (94%)                                            
      Hemorrhage                                                    1 (2%)                                                          
      Mineralization                                                             1 (2%)                                             
      Artery, Mineralization                                                     1 (2%)                                             
      Atrium, Thrombosis                                            6 (12%)      3 (6%)                                             
      Pericardium, Inflammation, Chronic                            1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (50)         (50)                                                
      Degeneration, Fatty                             35 (70%)     41 (82%)     43 (86%)                                            
      Hyperplasia                                     15 (30%)     10 (20%)     11 (22%)                                            
      Hypertrophy                                      4 (8%)       5 (10%)      3 (6%)                                             
      Pigmentation                                    43 (86%)     46 (92%)     39 (78%)                                            
   Adrenal Gland, Medulla                             (49)         (50)         (50)                                                
      Hyperplasia                                     10 (20%)     15 (30%)      4 (8%)                                             
   Islets, Pancreatic                                 (50)         (50)         (50)                                                
      Hyperplasia                                      1 (2%)       4 (8%)       3 (6%)                                             
   Parathyroid Gland                                  (42)         (45)         (44)                                                
      Hyperplasia                                      2 (5%)       1 (2%)       1 (2%)                                             
      Hypertrophy                                                   2 (4%)                                                          
   Pituitary Gland                                    (49)         (50)         (50)                                                
      Pars Distalis, Angiectasis                                    3 (6%)       1 (2%)                                             
      Pars Distalis, Atrophy                           1 (2%)                                                                       
      Pars Distalis, Cyst                              3 (6%)       6 (12%)      5 (10%)                                            
      Pars Distalis, Hemorrhage                        1 (2%)                    1 (2%)                                             
      Pars Distalis, Hyperplasia                      18 (37%)     22 (44%)     11 (22%)                                            
      Pars Intermedia, Angiectasis                                  2 (4%)       1 (2%)                                             
      Pars Intermedia, Cyst                            2 (4%)       2 (4%)       1 (2%)                                             
      Pars Intermedia, Hyperplasia                                  2 (4%)                                                          
      Pars Nervosa, Pigmentation                       1 (2%)                                                                       
   Thyroid Gland                                      (50)         (50)         (50)                                                
      Infiltration Cellular, Lymphocyte                1 (2%)                    1 (2%)                                             
      Ultimobranchial Cyst                             1 (2%)                    2 (4%)                                             
      C-Cell, Hyperplasia                             12 (24%)     20 (40%)     14 (28%)                                            
      Follicle, Ectasia                                3 (6%)       2 (4%)       3 (6%)                                             
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   11                                                              
NTP Experiment-Test: 05701-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                              TOLUENE                                          Date: 09/18/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:13:18  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0 PPM        600 PPM      1200 PPM                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Preputial Gland                                    (50)         (50)         (50)                                                
      Abscess                                          3 (6%)                                                                       
      Hyperplasia                                                   1 (2%)       1 (2%)                                             
      Inflammation, Acute                              1 (2%)                                                                       
      Inflammation, Chronic                           29 (58%)     28 (56%)     22 (44%)                                            
      Inflammation, Chronic Active                    10 (20%)     17 (34%)     25 (50%)                                            
      Mineralization                                                             1 (2%)                                             
      Duct, Ectasia                                    1 (2%)                    2 (4%)                                             
   Prostate                                           (50)         (50)         (50)                                                
      Atrophy                                          1 (2%)                                                                       
      Hyperplasia                                     10 (20%)      3 (6%)       3 (6%)                                             
      Inflammation, Acute                              7 (14%)      7 (14%)      5 (10%)                                            
      Inflammation, Chronic                            1 (2%)       3 (6%)       2 (4%)                                             
      Inflammation, Chronic Active                    14 (28%)      6 (12%)     10 (20%)                                            
   Seminal Vesicle                                                 (5)                                                              
      Dilatation                                                    1 (20%)                                                         
   Testes                                             (50)         (50)         (50)                                                
      Atrophy                                         11 (22%)     12 (24%)      9 (18%)                                            
      Congestion                                                    1 (2%)                                                          
      Mineralization                                                2 (4%)                                                          
      Arteriole, Inflammation, Chronic                              2 (4%)       1 (2%)                                             
      Interstitial Cell, Hyperplasia                  35 (70%)     46 (92%)     37 (74%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)                                                
      Myelofibrosis                                    3 (6%)       1 (2%)       5 (10%)                                            
   Lymph Node                                         (50)         (50)         (50)                                                
      Congestion                                                    1 (2%)                                                          
      Edema                                            1 (2%)                                                                       
      Hyperplasia, Lymphoid                            1 (2%)       2 (4%)                                                          
      Mediastinal, Congestion                          1 (2%)       5 (10%)                                                         
      Mediastinal, Hemorrhage                                                    1 (2%)                                             
      Mediastinal, Hyperplasia, Lymphoid                            1 (2%)       1 (2%)                                             
      Mesenteric, Congestion                           1 (2%)       1 (2%)       4 (8%)                                             
      Mesenteric, Hyperplasia, Lymphoid               17 (34%)     20 (40%)     22 (44%)                                            
      Mesenteric, Inflammation, Acute                               1 (2%)                                                          
      Popliteal, Hyperplasia, Lymphoid                                           1 (2%)                                             
   Lymph Node, Mandibular                             (36)         (45)         (37)                                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   12                                                              
NTP Experiment-Test: 05701-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                              TOLUENE                                          Date: 09/18/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:13:18  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0 PPM        600 PPM      1200 PPM                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Congestion                                      10 (28%)     10 (22%)      3 (8%)                                             
      Cyst                                             1 (3%)       1 (2%)       1 (3%)                                             
      Hyperplasia, Lymphoid                           32 (89%)     31 (69%)     30 (81%)                                            
   Spleen                                             (50)         (50)         (50)                                                
      Fibrosis                                         5 (10%)      3 (6%)       4 (8%)                                             
      Hematopoietic Cell Proliferation                42 (84%)     42 (84%)     40 (80%)                                            
      Hyperplasia, Lymphoid                            2 (4%)                    3 (6%)                                             
      Infarct                                                       1 (2%)                                                          
      Mineralization                                   1 (2%)                                                                       
      Pigmentation                                    39 (78%)     37 (74%)     42 (84%)                                            
   Thymus                                             (44)         (46)         (46)                                                
      Congestion                                       2 (5%)       5 (11%)      1 (2%)                                             
      Cyst                                             4 (9%)       1 (2%)                                                          
      Hyperplasia, Lymphoid                                         4 (9%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (48)         (49)                                                
      Inflammation, Acute                              2 (4%)                                                                       
      Inflammation, Chronic                            1 (2%)                                                                       
      Acinus, Ectasia                                 34 (68%)     25 (52%)     28 (57%)                                            
      Duct, Ectasia                                   10 (20%)     19 (40%)      8 (16%)                                            
   Skin                                               (50)         (50)         (50)                                                
      Abscess                                                       1 (2%)       1 (2%)                                             
      Cyst Epithelial Inclusion                        1 (2%)       2 (4%)                                                          
      Epidermis, Cyst                                  1 (2%)                                                                       
      Foot, Ulcer                                                                1 (2%)                                             
      Hair Follicle, Inflammation, Chronic                          1 (2%)                                                          
      Hair Follicle, Head, Hemorrhage                  1 (2%)                                                                       
      Hair Follicle, Head, Inflammation, Acute         1 (2%)                                                                       
      Head, Abscess                                                              1 (2%)                                             
      Head, Inflammation, Acute                        1 (2%)       1 (2%)       1 (2%)                                             
      Head, Inflammation, Chronic Active               1 (2%)                                                                       
      Subcutaneous Tissue, Edema                                    1 (2%)                                                          
      Subcutaneous Tissue, Hemorrhage                               1 (2%)                                                          
      Tail, Inflammation, Chronic Active               1 (2%)                                                                       
      Tail, Subcutaneous Tissue, Inflammation,                                                                                      
           Acute                                                                 1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)                                                
      Cranium, Abscess                                              1 (2%)                                                          
      Cranium, Fibrous Osteodystrophy                  1 (2%)       1 (2%)       2 (4%)                                             
      Cranium, Inflammation, Chronic                                             1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   13                                                              
NTP Experiment-Test: 05701-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                              TOLUENE                                          Date: 09/18/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:13:18  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0 PPM        600 PPM      1200 PPM                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
MUSCULOSKELETAL SYSTEM - CONT                                                                                                       
      Femur, Fibrous Osteodystrophy                    1 (2%)       4 (8%)       2 (4%)                                             
      Humerus, Fracture                                                          1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)                                                
      Compression                                      5 (10%)      7 (14%)      6 (12%)                                            
      Hemorrhage                                      11 (22%)      8 (16%)      2 (4%)                                             
      Necrosis                                         1 (2%)       1 (2%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)                                                
      Congestion                                       6 (12%)      3 (6%)       4 (8%)                                             
      Hemorrhage                                       8 (16%)      4 (8%)       5 (10%)                                            
      Infiltration Cellular, Lymphocyte               50 (100%)    47 (94%)     49 (98%)                                            
      Inflammation, Chronic                                                      1 (2%)                                             
      Metaplasia, Osseous                                                        1 (2%)                                             
      Pigmentation, Cholesterol                        1 (2%)       2 (4%)       2 (4%)                                             
      Alveolar Epithelium, Hyperplasia                 2 (4%)       2 (4%)       3 (6%)                                             
      Alveolus, Infiltration Cellular, Histiocyte     26 (52%)     18 (36%)     25 (50%)                                            
      Alveolus, Mineralization                                                   2 (4%)                                             
      Arteriole, Mineralization                       41 (82%)     40 (80%)     38 (76%)                                            
      Bronchiole, Inflammation, Acute                                            2 (4%)                                             
      Bronchiole, Mineralization                       1 (2%)                                                                       
      Interstitium, Inflammation, Chronic              5 (10%)      6 (12%)     10 (20%)                                            
      Interstitium, Inflammation, Chronic Active       5 (10%)                   2 (4%)                                             
      Peribronchiolar, Inflammation, Chronic                        3 (6%)                                                          
      Peribronchiolar, Inflammation, Chronic Active                 1 (2%)                                                          
      Pleura, Inflammation, Chronic Active             1 (2%)                                                                       
   Nose                                               (50)         (50)         (49)                                                
      Inflammation, Chronic Active                     1 (2%)                                                                       
      Lumen, Degeneration                                                        1 (2%)                                             
      Lumen, Foreign Body                              4 (8%)       5 (10%)      2 (4%)                                             
      Lumen, Hemorrhage                               31 (62%)     25 (50%)     35 (71%)                                            
      Mucosa, Hemorrhage                                            1 (2%)                                                          
      Mucosa, Inflammation, Acute                     30 (60%)     30 (60%)     40 (82%)                                            
      Mucosa, Inflammation, Chronic Active             1 (2%)                                                                       
      Nasolacrimal Duct, Degeneration                               1 (2%)                                                          
      Nasolacrimal Duct, Inflammation                  1 (2%)                                                                       
      Nasolacrimal Duct, Inflammation, Acute           4 (8%)       1 (2%)       2 (4%)                                             
      Nasopharyngeal Duct, Inflammation, Acute         1 (2%)                                                                       
      Olfactory Epithelium, Degeneration              39 (78%)     48 (96%)     42 (86%)                                            
      Olfactory Epithelium, Erosion                                 3 (6%)       8 (16%)                                            
      Olfactory Epithelium, Metaplasia                              1 (2%)       1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   14                                                              
NTP Experiment-Test: 05701-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                              TOLUENE                                          Date: 09/18/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:13:18  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0 PPM        600 PPM      1200 PPM                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Olfactory Epithelium, Metaplasia, Squamous                                 2 (4%)                                             
      Respiratory Epithelium, Degeneration            15 (30%)     37 (74%)     31 (63%)                                            
      Respiratory Epithelium, Erosion                  4 (8%)       6 (12%)      3 (6%)                                             
      Respiratory Epithelium, Hemorrhage                            1 (2%)                                                          
      Respiratory Epithelium, Metaplasia, Squamous     1 (2%)       1 (2%)                                                          
      Respiratory Epithelium, Ulcer                                              1 (2%)                                             
      Vomeronasal Organ, Inflammation, Acute           1 (2%)                    1 (2%)                                             
   Trachea                                            (50)         (50)         (50)                                                
      Inflammation, Acute                                           1 (2%)       3 (6%)                                             
      Inflammation, Chronic Active                                  3 (6%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (2)                       (2)                                                 
      Cataract                                         1 (50%)                   2 (100%)                                           
      Retina, Degeneration                             1 (50%)                   1 (50%)                                            
      Sclera, Mineralization                           1 (50%)                   2 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)                                                
      Congestion                                                    1 (2%)                                                          
      Infarct                                                                    2 (4%)                                             
      Infiltration Cellular, Lymphocyte                1 (2%)                                                                       
      Mineralization                                                             1 (2%)                                             
      Nephropathy, Chronic                            49 (98%)     48 (96%)     48 (96%)                                            
      Pelvis, Inflammation, Acute                                   1 (2%)       1 (2%)                                             
      Renal Tubule, Cyst                               1 (2%)       2 (4%)       5 (10%)                                            
      Renal Tubule, Hyperplasia                        4 (8%)       4 (8%)                                                          
      Renal Tubule, Pigmentation                      50 (100%)    48 (96%)     47 (94%)                                            
   Urinary Bladder                                    (50)         (50)         (50)                                                
      Calculus Gross Observation                       1 (2%)                                                                       
      Calculus Micro Observation Only                               1 (2%)                                                          
      Hemorrhage                                       1 (2%)                                                                       
      Inflammation, Acute                              1 (2%)                                                                       
      Inflammation, Chronic                            1 (2%)       1 (2%)                                                          
      Inflammation, Chronic Active                     1 (2%)       1 (2%)       2 (4%)                                             
      Transitional Epithelium, Hyperplasia                          1 (2%)                                                          
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   15                                                              
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NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.