TR 371 Rat Pathology Tables
INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
TOLUENE
NTP Experiment-Test: 05701-02 Report: PEIRPT05
Study Type: CHRONIC Date: 09/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:13:18
Facility: International Research and Development Corp.
Chemical CAS #: 108883
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05701-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TOLUENE Date: 09/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:13:18
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 600 PPM 1200 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 60 60 60
Scheduled Sacrifice 10 10 10
Early Deaths
Dead 6 7 6
Moribund 11 8 14
Survivors
Terminal Sacrifice 32 35 30
Dead 1
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (49) (50) (49)
Carcinoma, Metastatic, Thyroid Gland 1 (2%)
Intestine Small, Duodenum (50) (49) (49)
Intestine Small, Ileum (50) (49) (49)
Intestine Small, Jejunum (50) (49) (49)
Liver (50) (50) (50)
Hepatocellular Adenoma 2 (4%) 3 (6%)
Mesentery (1) (1) (2)
Pancreas (50) (49) (50)
Salivary Glands (50) (50) (50)
Stomach, Forestomach (50) (50) (50)
Squamous Cell Carcinoma 1 (2%)
Squamous Cell Papilloma 1 (2%)
Stomach, Glandular (50) (50) (50)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (50) (49) (49)
Adrenal Gland, Medulla (49) (48) (49)
Pheochromocytoma NOS 1 (2%) 4 (8%)
Islets, Pancreatic (50) (49) (50)
Carcinoma 2 (4%) 1 (2%)
Pituitary Gland (50) (50) (50)
Pars Distalis, Adenoma 31 (62%) 27 (54%) 31 (62%)
Page 2
NTP Experiment-Test: 05701-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TOLUENE Date: 09/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:13:18
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 600 PPM 1200 PPM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont
Pars Distalis, Craniopharyngioma 1 (2%)
Pars Intermedia, Adenoma 1 (2%)
Thyroid Gland (50) (50) (50)
C-Cell, Adenoma 2 (4%) 8 (16%) 3 (6%)
C-Cell, Carcinoma 2 (4%) 2 (4%) 2 (4%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (49) (50) (44)
Adenoma 2 (4%) 4 (8%) 3 (7%)
Ovary (50) (50) (50)
Granulosa Cell Tumor Malignant 2 (4%)
Uterus (50) (50) (50)
Adenocarcinoma 1 (2%)
Adenoma 1 (2%)
Endometrium, Polyp Stromal 4 (8%) 5 (10%) 2 (4%)
Endometrium, Sarcoma Stromal 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Blood (1)
Bone Marrow (49) (50) (50)
Lymph Node (50) (50) (50)
Lymph Node, Mandibular (47) (48) (42)
Carcinoma, Metastatic, Thyroid Gland 1 (2%)
Spleen (50) (50) (50)
Thymus (46) (46) (46)
Thymoma Benign 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (50) (50)
Adenocarcinoma 2 (4%) 1 (2%) 6 (12%)
Adenoma 2 (4%) 1 (2%) 1 (2%)
Fibroadenoma 13 (26%) 4 (8%) 7 (14%)
Skin (50) (50) (50)
Keratoacanthoma 1 (2%)
Subcutaneous Tissue, Fibroma 1 (2%)
Subcutaneous Tissue, Lipoma 1 (2%)
Page 3
NTP Experiment-Test: 05701-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TOLUENE Date: 09/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:13:18
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 600 PPM 1200 PPM
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont
Subcutaneous Tissue, Neurofibrosarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (49)
Astrocytoma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50)
Carcinoma, Metastatic, Thyroid Gland 1 (2%)
Nose (49) (50) (50)
Mucosa, Squamous Cell Carcinoma 1 (2%)
Trachea (50) (50) (50)
Carcinoma, Metastatic, Thyroid Gland 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (5) (4) (3)
Zymbal's Gland (1) (1)
Carcinoma 1 (100%)
Squamous Cell Carcinoma 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50)
Sarcoma 1 (2%)
Renal Tubule, Carcinoma 1 (2%)
Urinary Bladder (50) (50) (50)
Transitional Epithelium, Papilloma 1 (2%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50)
Leukemia Mononuclear 18 (36%) 16 (32%) 10 (20%)
Lymphoma Malignant Histiocytic 1 (2%)
* Number of animals with any tissue examined microscopically
Page 4
NTP Experiment-Test: 05701-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TOLUENE Date: 09/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:13:18
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 600 PPM 1200 PPM
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS - cont
Multiple Organs *(50) *(50) *(50)
____________________________________________________________________________________________________________________________________
Page 5
NTP Experiment-Test: 05701-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TOLUENE Date: 09/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:13:18
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 600 PPM 1200 PPM
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 46 43 43
Total Primary Neoplasms 86 77 84
Total Animals with Benign Neoplasms 39 37 34
Total Benign Neoplasms 60 53 52
Total Animals with Malignant Neoplasms 21 21 23
Total Malignant Neoplasms 25 24 28
Total Animals with Metastatic Neoplasms 1
Total Metastatic Neoplasm 4
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant 1 4
Total Uncertain Neoplasms 1 4
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 6
NTP Experiment-Test: 05701-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TOLUENE Date: 09/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:13:18
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 600 PPM 1200 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 60 60 60
Scheduled Sacrifice 10 10 10
Early Deaths
Moribund 14 11 23
Dead 6 8 5
Natural Death 3
Survivors
Terminal Sacrifice 29 27 22
Dead 1
Accident 1
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (50) (50) (50)
Intestine Large, Cecum (50) (50) (49)
Intestine Large, Colon (50) (50) (49)
Intestine Large, Rectum (49) (50) (49)
Intestine Small, Duodenum (50) (50) (49)
Intestine Small, Ileum (49) (50) (49)
Intestine Small, Jejunum (50) (50) (49)
Adenocarcinoma, Mucinous 1 (2%)
Liver (50) (50) (50)
Hepatocellular Carcinoma 1 (2%)
Hepatocellular Adenoma 4 (8%) 2 (4%)
Histiocytic Sarcoma, Metastatic 1 (2%)
Mesentery (2) (2) (4)
Pancreas (50) (50) (50)
Acinus, Adenoma 1 (2%)
Salivary Glands (50) (50) (50)
Stomach, Forestomach (50) (50) (49)
Stomach, Glandular (50) (50) (49)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50)
Carcinoma Adenosquamous, Metastatic, Lung 1 (2%)
____________________________________________________________________________________________________________________________________
Page 7
NTP Experiment-Test: 05701-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TOLUENE Date: 09/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:13:18
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 600 PPM 1200 PPM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland (50) (50) (50)
Capsule, Fibrosarcoma, Metastatic, Skin 1 (2%)
Adrenal Gland, Cortex (50) (50) (50)
Adenoma 1 (2%)
Adrenal Gland, Medulla (49) (50) (50)
Pheochromocytoma Malignant 1 (2%)
Pheochromocytoma NOS 7 (14%) 7 (14%) 6 (12%)
Bilateral, Pheochromocytoma NOS 1 (2%)
Islets, Pancreatic (50) (50) (50)
Adenoma 2 (4%) 2 (4%) 2 (4%)
Carcinoma 1 (2%) 1 (2%)
Pituitary Gland (49) (50) (50)
Pars Distalis, Adenoma 22 (45%) 24 (48%) 18 (36%)
Pars Distalis, Carcinoma 1 (2%)
Thyroid Gland (50) (50) (50)
C-Cell, Adenoma 5 (10%) 7 (14%) 8 (16%)
C-Cell, Carcinoma 1 (2%)
Follicle, Adenoma 1 (2%) 2 (4%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Preputial Gland (50) (50) (50)
Adenoma 1 (2%)
Carcinoma 1 (2%)
Prostate (50) (50) (50)
Testes (50) (50) (50)
Bilateral, Interstitial Cell, Adenoma 23 (46%) 27 (54%) 30 (60%)
Interstitial Cell, Adenoma 13 (26%) 9 (18%) 10 (20%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Blood (4) (1) (4)
Bone Marrow (50) (50) (50)
Lymph Node (50) (50) (50)
Carcinoma Adenosquamous, Metastatic, Lung 1 (2%)
Fibrosarcoma, Metastatic, Skin 1 (2%)
Renal, Carcinoma, Metastatic, Kidney 1 (2%)
Lymph Node, Mandibular (36) (45) (37)
Spleen (50) (50) (50)
Page 8
NTP Experiment-Test: 05701-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TOLUENE Date: 09/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:13:18
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 600 PPM 1200 PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont
Hemangiosarcoma 1 (2%)
Thymus (44) (46) (46)
Carcinoma, Metastatic, Kidney 1 (2%)
Carcinoma Adenosquamous, Metastatic, Lung 1 (2%)
Osteosarcoma, Metastatic, Uncertain Primary
Site 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (48) (49)
Fibroadenoma 1 (2%)
Skin (50) (50) (50)
Histiocytic Sarcoma, Metastatic 1 (2%)
Keratoacanthoma 1 (2%)
Subcutaneous Tissue, Fibroma 2 (4%) 1 (2%)
Subcutaneous Tissue, Fibrosarcoma 2 (4%) 1 (2%)
Tail, Squamous Cell Papilloma 1 (2%)
Thoracic, Subcutaneous Tissue, Fibroma 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Skeletal Muscle (1)
Fibrosarcoma 1 (100%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50)
Cerebrum, Astrocytoma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50)
Alveolar/Bronchiolar Carcinoma 1 (2%)
Carcinoma, Metastatic, Kidney 1 (2%)
Carcinoma Adenosquamous 1 (2%) 1 (2%)
Fibrosarcoma, Metastatic, Skin 1 (2%)
Fibrous Histiocytoma, Metastatic, Skin 1 (2%)
Histiocytic Sarcoma, Metastatic 1 (2%)
Osteosarcoma, Metastatic, Uncertain Primary
Site 1 (2%)
Trachea (50) (50) (50)
Carcinoma Adenosquamous, Metastatic, Lung 1 (2%)
____________________________________________________________________________________________________________________________________
Page 9
NTP Experiment-Test: 05701-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TOLUENE Date: 09/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:13:18
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 600 PPM 1200 PPM
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Zymbal's Gland (1) (2) (1)
Carcinoma 1 (100%) 2 (100%) 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50)
Histiocytic Sarcoma, Metastatic 1 (2%)
Capsule, Fibrosarcoma, Metastatic, Skin 1 (2%)
Renal Tubule, Adenoma 1 (2%) 2 (4%)
Transitional Epithelium, Carcinoma 1 (2%)
Urinary Bladder (50) (50) (50)
Fibrosarcoma, Metastatic, Skin 1 (2%)
Sarcoma 1 (2%)
Transitional Epithelium, Papilloma 1 (2%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50)
Leukemia Monocytic 1 (2%) 1 (2%)
Leukemia Mononuclear 17 (34%) 26 (52%) 19 (38%)
Lymphoma Malignant 1 (2%)
Lymphoma Malignant Lymphocytic 1 (2%)
Mesothelioma Malignant 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 10
NTP Experiment-Test: 05701-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TOLUENE Date: 09/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:13:18
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 600 PPM 1200 PPM
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 49 48 49
Total Primary Neoplasms 108 122 107
Total Animals with Benign Neoplasms 45 46 47
Total Benign Neoplasms 75 77 73
Total Animals with Malignant Neoplasms 23 31 26
Total Malignant Neoplasms 26 37 28
Total Animals with Metastatic Neoplasms 1 3 2
Total Metastatic Neoplasm 4 12 3
Total Animals with Malignant Neoplasms 1
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant 7 8 6
Total Uncertain Neoplasms 7 8 6
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
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