National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/5090

TR 371 Rat Pathology Tables


                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                              TOLUENE


NTP Experiment-Test: 05701-02                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 09/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:13:18




       Facility:  International Research and Development Corp.

       Chemical CAS #:  108883

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05701-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                              TOLUENE                                          Date: 09/18/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:13:18  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 PPM        600 PPM      1200 PPM                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          60           60           60                                                  
  Scheduled Sacrifice                                 10           10           10                                                  
  Early Deaths                                                                                                                      
    Dead                                               6            7            6                                                  
    Moribund                                          11            8           14                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                32           35           30                                                  
    Dead                                               1                                                                            
  Animals Examined Microscopically                    50           50           50                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (49)         (50)         (49)                                                
      Carcinoma, Metastatic, Thyroid Gland             1 (2%)                                                                       
   Intestine Small, Duodenum                          (50)         (49)         (49)                                                
   Intestine Small, Ileum                             (50)         (49)         (49)                                                
   Intestine Small, Jejunum                           (50)         (49)         (49)                                                
   Liver                                              (50)         (50)         (50)                                                
      Hepatocellular Adenoma                           2 (4%)       3 (6%)                                                          
   Mesentery                                          (1)          (1)          (2)                                                 
   Pancreas                                           (50)         (49)         (50)                                                
   Salivary Glands                                    (50)         (50)         (50)                                                
   Stomach, Forestomach                               (50)         (50)         (50)                                                
      Squamous Cell Carcinoma                                                    1 (2%)                                             
      Squamous Cell Papilloma                                                    1 (2%)                                             
   Stomach, Glandular                                 (50)         (50)         (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (49)         (49)                                                
   Adrenal Gland, Medulla                             (49)         (48)         (49)                                                
      Pheochromocytoma NOS                             1 (2%)                    4 (8%)                                             
   Islets, Pancreatic                                 (50)         (49)         (50)                                                
      Carcinoma                                                     2 (4%)       1 (2%)                                             
   Pituitary Gland                                    (50)         (50)         (50)                                                
      Pars Distalis, Adenoma                          31 (62%)     27 (54%)     31 (62%)                                            
                                                             Page   2                                                               
NTP Experiment-Test: 05701-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                              TOLUENE                                          Date: 09/18/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:13:18  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 PPM        600 PPM      1200 PPM                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - cont                                                                                                             
      Pars Distalis, Craniopharyngioma                              1 (2%)                                                          
      Pars Intermedia, Adenoma                         1 (2%)                                                                       
   Thyroid Gland                                      (50)         (50)         (50)                                                
      C-Cell, Adenoma                                  2 (4%)       8 (16%)      3 (6%)                                             
      C-Cell, Carcinoma                                2 (4%)       2 (4%)       2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (49)         (50)         (44)                                                
      Adenoma                                          2 (4%)       4 (8%)       3 (7%)                                             
   Ovary                                              (50)         (50)         (50)                                                
      Granulosa Cell Tumor Malignant                                             2 (4%)                                             
   Uterus                                             (50)         (50)         (50)                                                
      Adenocarcinoma                                                             1 (2%)                                             
      Adenoma                                          1 (2%)                                                                       
      Endometrium, Polyp Stromal                       4 (8%)       5 (10%)      2 (4%)                                             
      Endometrium, Sarcoma Stromal                     1 (2%)                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Blood                                                           (1)                                                              
   Bone Marrow                                        (49)         (50)         (50)                                                
   Lymph Node                                         (50)         (50)         (50)                                                
   Lymph Node, Mandibular                             (47)         (48)         (42)                                                
      Carcinoma, Metastatic, Thyroid Gland             1 (2%)                                                                       
   Spleen                                             (50)         (50)         (50)                                                
   Thymus                                             (46)         (46)         (46)                                                
      Thymoma Benign                                   1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (50)         (50)                                                
      Adenocarcinoma                                   2 (4%)       1 (2%)       6 (12%)                                            
      Adenoma                                          2 (4%)       1 (2%)       1 (2%)                                             
      Fibroadenoma                                    13 (26%)      4 (8%)       7 (14%)                                            
   Skin                                               (50)         (50)         (50)                                                
      Keratoacanthoma                                                            1 (2%)                                             
      Subcutaneous Tissue, Fibroma                                               1 (2%)                                             
      Subcutaneous Tissue, Lipoma                                                1 (2%)                                             
                                                             Page   3                                                               
NTP Experiment-Test: 05701-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                              TOLUENE                                          Date: 09/18/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:13:18  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 PPM        600 PPM      1200 PPM                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - cont                                                                                                         
      Subcutaneous Tissue, Neurofibrosarcoma                        1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (49)                                                
      Astrocytoma Malignant                            1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)                                                
      Carcinoma, Metastatic, Thyroid Gland             1 (2%)                                                                       
   Nose                                               (49)         (50)         (50)                                                
      Mucosa, Squamous Cell Carcinoma                                            1 (2%)                                             
   Trachea                                            (50)         (50)         (50)                                                
      Carcinoma, Metastatic, Thyroid Gland             1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (5)          (4)          (3)                                                 
   Zymbal's Gland                                     (1)          (1)                                                              
      Carcinoma                                        1 (100%)                                                                     
      Squamous Cell Carcinoma                                       1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)                                                
      Sarcoma                                                                    1 (2%)                                             
      Renal Tubule, Carcinoma                                                    1 (2%)                                             
   Urinary Bladder                                    (50)         (50)         (50)                                                
      Transitional Epithelium, Papilloma               1 (2%)                                                                       
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)                                                
      Leukemia Mononuclear                            18 (36%)     16 (32%)     10 (20%)                                            
      Lymphoma Malignant Histiocytic                                1 (2%)                                                          
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   4                                                               
NTP Experiment-Test: 05701-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                              TOLUENE                                          Date: 09/18/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:13:18  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 PPM        600 PPM      1200 PPM                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SYSTEMIC LESIONS - cont                                                                                                            
   Multiple Organs                                   *(50)        *(50)        *(50)                                                
____________________________________________________________________________________________________________________________________
                                                             Page   5                                                               
NTP Experiment-Test: 05701-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                              TOLUENE                                          Date: 09/18/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:13:18  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 PPM        600 PPM      1200 PPM                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            46          43          43                                                   
     Total Primary Neoplasms                           86          77          84                                                   
                                                                                                                                    
   Total Animals with Benign Neoplasms                 39          37          34                                                   
     Total Benign Neoplasms                            60          53          52                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms              21          21          23                                                   
     Total Malignant Neoplasms                         25          24          28                                                   
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              1                                                                           
     Total Metastatic Neoplasm                          4                                                                           
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                  1                       4                                                   
     Total Uncertain Neoplasms                          1                       4                                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   6                                                               
NTP Experiment-Test: 05701-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                              TOLUENE                                          Date: 09/18/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:13:18  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 PPM        600 PPM      1200 PPM                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          60           60           60                                                  
  Scheduled Sacrifice                                 10           10           10                                                  
  Early Deaths                                                                                                                      
    Moribund                                          14           11           23                                                  
    Dead                                               6            8            5                                                  
    Natural Death                                                   3                                                               
  Survivors                                                                                                                         
    Terminal Sacrifice                                29           27           22                                                  
    Dead                                                            1                                                               
    Accident                                           1                                                                            
  Animals Examined Microscopically                    50           50           50                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (50)         (50)         (50)                                                
   Intestine Large, Cecum                             (50)         (50)         (49)                                                
   Intestine Large, Colon                             (50)         (50)         (49)                                                
   Intestine Large, Rectum                            (49)         (50)         (49)                                                
   Intestine Small, Duodenum                          (50)         (50)         (49)                                                
   Intestine Small, Ileum                             (49)         (50)         (49)                                                
   Intestine Small, Jejunum                           (50)         (50)         (49)                                                
      Adenocarcinoma, Mucinous                         1 (2%)                                                                       
   Liver                                              (50)         (50)         (50)                                                
      Hepatocellular Carcinoma                                      1 (2%)                                                          
      Hepatocellular Adenoma                           4 (8%)       2 (4%)                                                          
      Histiocytic Sarcoma, Metastatic                               1 (2%)                                                          
   Mesentery                                          (2)          (2)          (4)                                                 
   Pancreas                                           (50)         (50)         (50)                                                
      Acinus, Adenoma                                  1 (2%)                                                                       
   Salivary Glands                                    (50)         (50)         (50)                                                
   Stomach, Forestomach                               (50)         (50)         (49)                                                
   Stomach, Glandular                                 (50)         (50)         (49)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)                                                
      Carcinoma Adenosquamous, Metastatic, Lung        1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   7                                                               
NTP Experiment-Test: 05701-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                              TOLUENE                                          Date: 09/18/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:13:18  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 PPM        600 PPM      1200 PPM                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (50)         (50)         (50)                                                
      Capsule, Fibrosarcoma, Metastatic, Skin                       1 (2%)                                                          
   Adrenal Gland, Cortex                              (50)         (50)         (50)                                                
      Adenoma                                                       1 (2%)                                                          
   Adrenal Gland, Medulla                             (49)         (50)         (50)                                                
      Pheochromocytoma Malignant                                    1 (2%)                                                          
      Pheochromocytoma NOS                             7 (14%)      7 (14%)      6 (12%)                                            
      Bilateral, Pheochromocytoma NOS                               1 (2%)                                                          
   Islets, Pancreatic                                 (50)         (50)         (50)                                                
      Adenoma                                          2 (4%)       2 (4%)       2 (4%)                                             
      Carcinoma                                        1 (2%)                    1 (2%)                                             
   Pituitary Gland                                    (49)         (50)         (50)                                                
      Pars Distalis, Adenoma                          22 (45%)     24 (48%)     18 (36%)                                            
      Pars Distalis, Carcinoma                                                   1 (2%)                                             
   Thyroid Gland                                      (50)         (50)         (50)                                                
      C-Cell, Adenoma                                  5 (10%)      7 (14%)      8 (16%)                                            
      C-Cell, Carcinoma                                             1 (2%)                                                          
      Follicle, Adenoma                                1 (2%)       2 (4%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Preputial Gland                                    (50)         (50)         (50)                                                
      Adenoma                                                       1 (2%)                                                          
      Carcinoma                                        1 (2%)                                                                       
   Prostate                                           (50)         (50)         (50)                                                
   Testes                                             (50)         (50)         (50)                                                
      Bilateral, Interstitial Cell, Adenoma           23 (46%)     27 (54%)     30 (60%)                                            
      Interstitial Cell, Adenoma                      13 (26%)      9 (18%)     10 (20%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Blood                                              (4)          (1)          (4)                                                 
   Bone Marrow                                        (50)         (50)         (50)                                                
   Lymph Node                                         (50)         (50)         (50)                                                
      Carcinoma Adenosquamous, Metastatic, Lung        1 (2%)                                                                       
      Fibrosarcoma, Metastatic, Skin                                1 (2%)                                                          
      Renal, Carcinoma, Metastatic, Kidney                          1 (2%)                                                          
   Lymph Node, Mandibular                             (36)         (45)         (37)                                                
   Spleen                                             (50)         (50)         (50)                                                
                                                             Page   8                                                               
NTP Experiment-Test: 05701-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                              TOLUENE                                          Date: 09/18/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:13:18  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 PPM        600 PPM      1200 PPM                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - cont                                                                                                         
      Hemangiosarcoma                                               1 (2%)                                                          
   Thymus                                             (44)         (46)         (46)                                                
      Carcinoma, Metastatic, Kidney                                 1 (2%)                                                          
      Carcinoma Adenosquamous, Metastatic, Lung        1 (2%)                                                                       
      Osteosarcoma, Metastatic, Uncertain Primary                                                                                   
          Site                                                                   1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (48)         (49)                                                
      Fibroadenoma                                     1 (2%)                                                                       
   Skin                                               (50)         (50)         (50)                                                
      Histiocytic Sarcoma, Metastatic                               1 (2%)                                                          
      Keratoacanthoma                                               1 (2%)                                                          
      Subcutaneous Tissue, Fibroma                     2 (4%)                    1 (2%)                                             
      Subcutaneous Tissue, Fibrosarcoma                             2 (4%)       1 (2%)                                             
      Tail, Squamous Cell Papilloma                                              1 (2%)                                             
      Thoracic, Subcutaneous Tissue, Fibroma           1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                                              (1)                                                 
      Fibrosarcoma                                                               1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)                                                
      Cerebrum, Astrocytoma Malignant                               1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)                                                
      Alveolar/Bronchiolar Carcinoma                                1 (2%)                                                          
      Carcinoma, Metastatic, Kidney                                 1 (2%)                                                          
      Carcinoma Adenosquamous                          1 (2%)                    1 (2%)                                             
      Fibrosarcoma, Metastatic, Skin                                1 (2%)                                                          
      Fibrous Histiocytoma, Metastatic, Skin                                     1 (2%)                                             
      Histiocytic Sarcoma, Metastatic                               1 (2%)                                                          
      Osteosarcoma, Metastatic, Uncertain Primary                                                                                   
          Site                                                                   1 (2%)                                             
   Trachea                                            (50)         (50)         (50)                                                
      Carcinoma Adenosquamous, Metastatic, Lung        1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                             Page   9                                                               
NTP Experiment-Test: 05701-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                              TOLUENE                                          Date: 09/18/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:13:18  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 PPM        600 PPM      1200 PPM                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Zymbal's Gland                                     (1)          (2)          (1)                                                 
      Carcinoma                                        1 (100%)     2 (100%)     1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)                                                
      Histiocytic Sarcoma, Metastatic                               1 (2%)                                                          
      Capsule, Fibrosarcoma, Metastatic, Skin                       1 (2%)                                                          
      Renal Tubule, Adenoma                                         1 (2%)       2 (4%)                                             
      Transitional Epithelium, Carcinoma                            1 (2%)                                                          
   Urinary Bladder                                    (50)         (50)         (50)                                                
      Fibrosarcoma, Metastatic, Skin                                1 (2%)                                                          
      Sarcoma                                          1 (2%)                                                                       
      Transitional Epithelium, Papilloma                                         1 (2%)                                             
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)                                                
      Leukemia Monocytic                               1 (2%)                    1 (2%)                                             
      Leukemia Mononuclear                            17 (34%)     26 (52%)     19 (38%)                                            
      Lymphoma Malignant                                                         1 (2%)                                             
      Lymphoma Malignant Lymphocytic                   1 (2%)                                                                       
      Mesothelioma Malignant                           1 (2%)                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  10                                                               
NTP Experiment-Test: 05701-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                              TOLUENE                                          Date: 09/18/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:13:18  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 PPM        600 PPM      1200 PPM                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            49          48          49                                                   
     Total Primary Neoplasms                          108         122         107                                                   
                                                                                                                                    
   Total Animals with Benign Neoplasms                 45          46          47                                                   
     Total Benign Neoplasms                            75          77          73                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms              23          31          26                                                   
     Total Malignant Neoplasms                         26          37          28                                                   
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              1           3           2                                                   
     Total Metastatic Neoplasm                          4          12           3                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                       1                                                   
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                  7           8           6                                                   
     Total Uncertain Neoplasms                          7           8           6                                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  11                                                               
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