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TR 373 Rat Pathology Tables


                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                                         SUCCINIC ANHYDRIDE


NTP Experiment-Test: 05041-01                                                                                     Report: PEIRPT03
Study Type: CHRONIC                                                                                               Date: 09/05/94
Route: GAVAGE                                                                                                     Time: 13:16:42




       Facility:  Microbiological Associates

       Chemical CAS #:  108-30-5

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05041-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 13:16:42  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   CONTROL      50MG/KG      100MG/KG                                               
                                                   FEMALE       LOW FEM       HIGHFEM                                               
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          60           60           60                                                  
  Early Deaths                                                                                                                      
    Dead                                              10           11           10                                                  
    Moribund                                          18           15           14                                                  
    Gavage Death                                       1            6            9                                                  
    Accident                                                        1                                                               
  Survivors                                                                                                                         
    Terminal Sacrifice                                30           27           26                                                  
    Dead                                                                         1                                                  
    Moribund                                           1                                                                            
  Animals Examined Microscopically                    60           60           60                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (60)         (45)         (60)                                                
      Hemorrhage                                                    1 (2%)                                                          
      Inflammation, Chronic                                                      3 (5%)                                             
      Adventitia, Fibrosis                                                       1 (2%)                                             
      Muscularis, Regeneration                         1 (2%)                    2 (3%)                                             
   Intestine Large, Colon                             (55)         (44)         (55)                                                
      Inflammation, Acute                              1 (2%)                                                                       
   Intestine Large, Rectum                            (53)         (35)         (53)                                                
      Inflammation, Acute                              1 (2%)                                                                       
      Inflammation, Chronic                            1 (2%)                                                                       
   Liver                                              (60)         (52)         (60)                                                
      Angiectasis                                      1 (2%)                                                                       
      Basophilic Focus                                              3 (6%)                                                          
      Basophilic Focus, Multiple                      27 (45%)     16 (31%)     25 (42%)                                            
      Congestion                                                    2 (4%)       3 (5%)                                             
      Cytologic Alterations                            1 (2%)       1 (2%)       6 (10%)                                            
      Cytologic Alterations, Multiple                  1 (2%)       1 (2%)                                                          
      Fibrosis, Focal                                  6 (10%)     12 (23%)     10 (17%)                                            
      Hematopoietic Cell Proliferation                 1 (2%)                                                                       
      Hepatodiaphragmatic Nodule                       5 (8%)      12 (23%)     14 (23%)                                            
      Hyperplasia, Nodular                                          3 (6%)       1 (2%)                                             
      Inflammation, Acute                                                        1 (2%)                                             
      Inflammation, Chronic                           16 (27%)     15 (29%)     15 (25%)                                            
      Necrosis, Focal                                  1 (2%)       1 (2%)                                                          
      Necrosis, Multifocal                                          3 (6%)       2 (3%)                                             
      Vacuolization Cytoplasmic                        6 (10%)      3 (6%)       4 (7%)                                             
      Bile Duct, Hyperplasia                          19 (32%)      6 (12%)      9 (15%)                                            
      Centrilobular, Congestion                                                  1 (2%)                                             
      Centrilobular, Fibrosis, Multifocal                           1 (2%)                                                          
      Centrilobular, Necrosis                                       3 (6%)                                                          
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05041-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 13:16:42  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   CONTROL      50MG/KG      100MG/KG                                               
                                                   FEMALE       LOW FEM       HIGHFEM                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Centrilobular, Vacuolization Cytoplasmic         5 (8%)       1 (2%)       1 (2%)                                             
      Hepatocyte, Inclusion Body Intranuclear                                    1 (2%)                                             
   Mesentery                                          (6)          (6)          (3)                                                 
      Hemorrhage                                                    1 (17%)      1 (33%)                                            
      Inflammation, Chronic                                         1 (17%)      1 (33%)                                            
      Fat, Necrosis                                    3 (50%)      4 (67%)      2 (67%)                                            
   Pancreas                                           (59)         (44)         (59)                                                
      Cyst                                                                       1 (2%)                                             
      Ectopic Tissue                                   1 (2%)                                                                       
      Hemorrhage                                                                 1 (2%)                                             
      Inflammation, Acute                                           1 (2%)                                                          
      Inflammation, Chronic                            1 (2%)                    1 (2%)                                             
      Acinus, Atrophy, Diffuse                         2 (3%)                                                                       
      Acinus, Atrophy, Focal                          10 (17%)      5 (11%)      5 (8%)                                             
      Acinus, Hyperplasia                              1 (2%)                                                                       
   Stomach, Forestomach                               (58)         (44)         (57)                                                
      Edema                                                         1 (2%)                                                          
      Erosion, Acute                                                             1 (2%)                                             
      Foreign Body                                     1 (2%)                                                                       
      Hyperplasia, Focal                                                         1 (2%)                                             
      Inflammation, Acute                                           2 (5%)                                                          
      Inflammation, Chronic                            3 (5%)       1 (2%)       1 (2%)                                             
      Epithelium, Hyperplasia                          1 (2%)       1 (2%)                                                          
   Stomach, Glandular                                 (58)         (45)         (54)                                                
      Inflammation, Acute                                           1 (2%)                                                          
      Inflammation, Chronic                            1 (2%)                                                                       
      Epithelium, Cyst                                                           1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (1)                                                                           
      Foreign Body                                     1 (100%)                                                                     
      Aorta, Inflammation, Chronic Active              1 (100%)                                                                     
   Heart                                              (60)         (45)         (60)                                                
      Cardiomyopathy                                  38 (63%)     18 (40%)     21 (35%)                                            
      Foreign Body                                                  1 (2%)                                                          
      Atrium, Thrombosis                                            1 (2%)       1 (2%)                                             
      Coronary Artery, Inflammation, Chronic                                     1 (2%)                                             
      Epicardium, Foreign Body                                                   2 (3%)                                             
      Epicardium, Inflammation, Acute                                            2 (3%)                                             
      Epicardium, Inflammation, Chronic                             2 (4%)                                                          
      Epicardium, Inflammation, Chronic Active         1 (2%)                    3 (5%)                                             
      Epicardium, Necrosis                                          2 (4%)       2 (3%)                                             
      Pericardium, Inflammation, Acute                              1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05041-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 13:16:42  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   CONTROL      50MG/KG      100MG/KG                                               
                                                   FEMALE       LOW FEM       HIGHFEM                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (60)         (45)         (59)                                                
      Angiectasis                                      1 (2%)                                                                       
      Congestion                                                    1 (2%)       2 (3%)                                             
      Hematopoietic Cell Proliferation                 1 (2%)                                                                       
      Hyperplasia                                      4 (7%)                    2 (3%)                                             
      Hypertrophy                                                                1 (2%)                                             
      Hypertrophy, Focal                                            1 (2%)                                                          
      Metaplasia, Osseous                                           1 (2%)                                                          
      Necrosis, Focal                                  2 (3%)       5 (11%)      1 (2%)                                             
      Vacuolization Cytoplasmic, Focal                 1 (2%)                    6 (10%)                                            
   Adrenal Gland, Medulla                             (59)         (43)         (54)                                                
      Hyperplasia                                     11 (19%)      3 (7%)       9 (17%)                                            
   Pituitary Gland                                    (60)         (55)         (60)                                                
      Hemorrhage                                                                 1 (2%)                                             
      Pars Distalis, Angiectasis                       9 (15%)      9 (16%)      8 (13%)                                            
      Pars Distalis, Concretion                        1 (2%)                                                                       
      Pars Distalis, Cyst                              4 (7%)                    3 (5%)                                             
      Pars Distalis, Degeneration, Focal               1 (2%)                    1 (2%)                                             
      Pars Distalis, Hyperplasia                       2 (3%)       2 (4%)       7 (12%)                                            
      Pars Distalis, Pigmentation                                   1 (2%)                                                          
   Thyroid Gland                                      (59)         (45)         (60)                                                
      C-Cell, Hyperplasia                              8 (14%)      4 (9%)       5 (8%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (39)         (27)         (53)                                                
      Dilatation                                       2 (5%)       1 (4%)       1 (2%)                                             
      Hyperplasia                                      1 (3%)                                                                       
      Inflammation, Acute                              1 (3%)       1 (4%)       1 (2%)                                             
   Ovary                                              (59)         (44)         (60)                                                
      Atrophy                                                                    2 (3%)                                             
      Congestion                                                                 2 (3%)                                             
      Cyst                                             4 (7%)       4 (9%)       2 (3%)                                             
      Hemorrhage                                                    1 (2%)                                                          
   Uterus                                             (59)         (48)         (60)                                                
      Congestion                                                                 1 (2%)                                             
      Hemorrhage                                       1 (2%)       1 (2%)       1 (2%)                                             
      Endometrium, Hyperplasia, Cystic                 4 (7%)       3 (6%)                                                          
   Vagina                                                                       (1)                                                 
      Inflammation, Acute                                                        1 (100%)                                           
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05041-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 13:16:42  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   CONTROL      50MG/KG      100MG/KG                                               
                                                   FEMALE       LOW FEM       HIGHFEM                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (60)         (45)         (60)                                                
      Hyperplasia                                      3 (5%)                    1 (2%)                                             
      Hyperplasia, Reticulum Cell                      1 (2%)       2 (4%)       1 (2%)                                             
      Hypoplasia                                                    1 (2%)                                                          
   Lymph Node                                         (59)         (45)         (60)                                                
      Mediastinal, Foreign Body                                                  2 (3%)                                             
      Mediastinal, Giant Cell, Multiple                             1 (2%)                                                          
      Mediastinal, Hemorrhage                                                    1 (2%)                                             
   Lymph Node, Mandibular                             (54)         (43)         (55)                                                
      Congestion                                                                 1 (2%)                                             
      Cyst                                                                       1 (2%)                                             
      Hemorrhage                                       1 (2%)       2 (5%)                                                          
      Hyperplasia, Lymphoid                            1 (2%)       1 (2%)                                                          
   Lymph Node, Mesenteric                             (59)         (43)         (59)                                                
      Edema                                            1 (2%)       2 (5%)                                                          
      Hemorrhage                                                                 3 (5%)                                             
      Pigmentation                                                  1 (2%)                                                          
   Spleen                                             (59)         (46)         (60)                                                
      Congestion                                                    1 (2%)                                                          
      Fibrosis, Focal                                                            1 (2%)                                             
      Hematopoietic Cell Proliferation                 6 (10%)      3 (7%)       1 (2%)                                             
      Infarct                                                       1 (2%)                                                          
      Inflammation, Chronic                                                      1 (2%)                                             
      Pigmentation                                    10 (17%)      7 (15%)      9 (15%)                                            
   Thymus                                             (48)         (41)         (52)                                                
      Hemorrhage                                                                 2 (4%)                                             
      Necrosis                                                      2 (5%)       2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (59)         (55)         (59)                                                
      Dilatation                                       8 (14%)      4 (7%)       1 (2%)                                             
      Hyperplasia                                      2 (3%)       3 (5%)       2 (3%)                                             
   Skin                                               (60)         (44)         (60)                                                
      Subcutaneous Tissue, Inflammation, Acute                                   1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (60)         (45)         (60)                                                
      Cranium, Hemorrhage                                           1 (2%)                                                          
      Cranium, Femur, Hyperostosis                     2 (3%)                                                                       
   Skeletal Muscle                                    (1)                       (1)                                                 
      Inflammation, Chronic Active                                               1 (100%)                                           
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05041-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 13:16:42  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   CONTROL      50MG/KG      100MG/KG                                               
                                                   FEMALE       LOW FEM       HIGHFEM                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (60)         (45)         (60)                                                
      Abscess                                          1 (2%)                                                                       
      Hemorrhage                                                    3 (7%)                                                          
      Thrombosis, Focal                                1 (2%)                                                                       
      Thrombosis, Multifocal                                                     1 (2%)                                             
      Meninges, Infiltration Cellular, Lymphocyte                                1 (2%)                                             
      Pons, Vacuolization Cytoplasmic                                            1 (2%)                                             
      Thalamus, Compression                            1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Larynx                                             (58)         (44)         (60)                                                
      Inflammation, Chronic                                                      1 (2%)                                             
      Necrosis                                                      1 (2%)                                                          
   Lung                                               (60)         (49)         (60)                                                
      Congestion                                       2 (3%)       5 (10%)      9 (15%)                                            
      Edema                                                         1 (2%)       2 (3%)                                             
      Fibrosis, Focal                                                            1 (2%)                                             
      Foreign Body                                     2 (3%)       7 (14%)      8 (13%)                                            
      Hemorrhage                                       3 (5%)       3 (6%)       3 (5%)                                             
      Hyperplasia, Adenomatous                         4 (7%)       4 (8%)       4 (7%)                                             
      Infiltration Cellular, Histiocyte               23 (38%)     13 (27%)     24 (40%)                                            
      Inflammation, Acute                              2 (3%)       3 (6%)       3 (5%)                                             
      Inflammation, Chronic                                         1 (2%)       2 (3%)                                             
      Inflammation, Granulomatous                                   1 (2%)                                                          
      Pigmentation                                                  1 (2%)       2 (3%)                                             
      Alveolar Epithelium, Hyperplasia                 1 (2%)                                                                       
      Bronchiole, Foreign Body                                                   1 (2%)                                             
      Bronchiole, Inflammation, Acute                                            2 (3%)                                             
      Bronchiole, Inflammation, Subacute                                         1 (2%)                                             
      Mediastinum, Foreign Body                        1 (2%)                    1 (2%)                                             
      Mediastinum, Hemorrhage                                                    1 (2%)                                             
      Mediastinum, Inflammation, Acute                 1 (2%)                                                                       
      Mediastinum, Inflammation, Chronic Active        1 (2%)                    3 (5%)                                             
      Mediastinum, Necrosis                                                      1 (2%)                                             
      Pleura, Fibrosis                                                           3 (5%)                                             
      Pleura, Foreign Body                                          1 (2%)                                                          
      Pleura, Inflammation, Acute                                   1 (2%)                                                          
      Pleura, Inflammation, Chronic                    2 (3%)                                                                       
      Pleura, Inflammation, Chronic Active                                       2 (3%)                                             
      Pleura, Necrosis                                              5 (10%)      4 (7%)                                             
   Nose                                               (59)         (50)         (57)                                                
      Foreign Body                                                  1 (2%)                                                          
      Sinus, Foreign Body                              1 (2%)       2 (4%)       5 (9%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05041-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 13:16:42  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   CONTROL      50MG/KG      100MG/KG                                               
                                                   FEMALE       LOW FEM       HIGHFEM                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Sinus, Fungus                                    1 (2%)                    2 (4%)                                             
      Sinus, Hemorrhage                                                          1 (2%)                                             
      Sinus, Inflammation, Acute                       2 (3%)       7 (14%)      9 (16%)                                            
      Turbinate, Inflammation, Chronic                 2 (3%)       1 (2%)                                                          
      Turbinate, Inflammation, Subacute                                          2 (4%)                                             
      Turbinate, Necrosis                                                        1 (2%)                                             
   Trachea                                            (60)         (44)         (60)                                                
      Hemorrhage                                                                 1 (2%)                                             
      Inflammation, Chronic                                                      1 (2%)                                             
      Necrosis                                                      1 (2%)       5 (8%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (4)          (8)          (4)                                                 
      Abscess                                          1 (25%)                                                                      
      Lens Capsule, Cataract                           1 (25%)      4 (50%)      4 (100%)                                           
      Retina, Atrophy                                  3 (75%)      5 (63%)      4 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (59)         (60)                                                
      Congestion                                                    1 (2%)                                                          
      Cyst                                             1 (2%)                    1 (2%)                                             
      Hemorrhage                                                    1 (2%)                                                          
      Mineralization                                   1 (2%)                                                                       
      Nephropathy                                     20 (33%)     15 (25%)      9 (15%)                                            
      Pigmentation                                                  2 (3%)       1 (2%)                                             
      Papilla, Necrosis                                1 (2%)                                                                       
      Pelvis, Dilatation                               1 (2%)                                                                       
      Pelvis, Mineralization                           5 (8%)       3 (5%)       3 (5%)                                             
      Renal Tubule, Atrophy                                         1 (2%)                                                          
      Renal Tubule, Vacuolization Cytoplasmic          1 (2%)                                                                       
   Urinary Bladder                                    (56)         (41)         (60)                                                
      Angiectasis                                      1 (2%)                                                                       
      Hyperplasia                                      1 (2%)                                                                       
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 05041-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 13:16:42  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     CONTROL      50MG/KG      100MG/KG                                               
                                                   MALE         LOW MALE     HIGHMALE                                               
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          60           60           60                                                  
  Early Deaths                                                                                                                      
    Moribund                                          15           16           10                                                  
    Dead                                               8            9           14                                                  
    Gavage Death                                       1            2            4                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                36           33           32                                                  
  Animals Examined Microscopically                    60           60           60                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (60)         (28)         (60)                                                
      Fibrosis, Focal                                  1 (2%)                                                                       
      Inflammation, Acute                                                        1 (2%)                                             
      Necrosis                                                      1 (4%)                                                          
      Muscularis, Regeneration                                                   1 (2%)                                             
   Intestine Large                                    (54)         (27)         (54)                                                
      Circumanal Gland, Hyperplasia                                              2 (4%)                                             
   Intestine Large, Cecum                             (52)         (24)         (53)                                                
      Inflammation, Acute                                           1 (4%)                                                          
      Parasite Protozoan                                            1 (4%)       1 (2%)                                             
   Intestine Small, Ileum                             (53)         (24)         (51)                                                
      Foreign Body                                     1 (2%)                                                                       
      Inflammation, Chronic                            1 (2%)                                                                       
   Liver                                              (60)         (47)         (60)                                                
      Angiectasis                                      3 (5%)       3 (6%)       1 (2%)                                             
      Basophilic Focus                                 4 (7%)       7 (15%)      2 (3%)                                             
      Basophilic Focus, Multiple                      15 (25%)      5 (11%)     19 (32%)                                            
      Congestion                                                    4 (9%)       3 (5%)                                             
      Cytologic Alterations                            2 (3%)       4 (9%)       1 (2%)                                             
      Cytologic Alterations, Multiple                  5 (8%)                    1 (2%)                                             
      Fibrosis, Focal                                  5 (8%)       4 (9%)       4 (7%)                                             
      Hemorrhage                                       1 (2%)                                                                       
      Hepatodiaphragmatic Nodule                       6 (10%)      9 (19%)      6 (10%)                                            
      Hyperplasia, Focal                               2 (3%)       4 (9%)                                                          
      Hyperplasia, Nodular                             1 (2%)       1 (2%)                                                          
      Inflammation, Chronic                            6 (10%)      1 (2%)       4 (7%)                                             
      Necrosis, Focal                                  1 (2%)       1 (2%)                                                          
      Necrosis, Multifocal                             1 (2%)                                                                       
      Vacuolization Cytoplasmic                        6 (10%)      7 (15%)      4 (7%)                                             
      Bile Duct, Cyst                                  1 (2%)                                                                       
      Bile Duct, Hyperplasia                          42 (70%)     28 (60%)     46 (77%)                                            
      Centrilobular, Congestion                                     1 (2%)                                                          
      Centrilobular, Necrosis                          1 (2%)       2 (4%)       3 (5%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
NTP Experiment-Test: 05041-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 13:16:42  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     CONTROL      50MG/KG      100MG/KG                                               
                                                   MALE         LOW MALE     HIGHMALE                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Centrilobular, Vacuolization Cytoplasmic         2 (3%)                    3 (5%)                                             
   Mesentery                                          (13)         (14)         (12)                                                
      Inflammation, Chronic                            2 (15%)                                                                      
      Artery, Inflammation, Multifocal                                           1 (8%)                                             
      Fat, Necrosis                                   12 (92%)     10 (71%)     11 (92%)                                            
   Pancreas                                           (59)         (26)         (59)                                                
      Cyst                                                          2 (8%)                                                          
      Inflammation, Chronic                            1 (2%)                                                                       
      Acinus, Atrophy, Diffuse                         1 (2%)       1 (4%)                                                          
      Acinus, Atrophy, Focal                          22 (37%)      2 (8%)      17 (29%)                                            
      Acinus, Hyperplasia, Focal                       1 (2%)                                                                       
      Artery, Inflammation, Chronic                    1 (2%)                    1 (2%)                                             
      Artery, Inflammation, Chronic Active             1 (2%)                                                                       
   Pharynx                                                                      (1)                                                 
      Developmental Malformation                                                 1 (100%)                                           
   Salivary Glands                                    (58)         (27)         (58)                                                
      Cyst                                             1 (2%)                                                                       
      Hemorrhage                                       1 (2%)                                                                       
      Inflammation, Chronic                            2 (3%)                    1 (2%)                                             
      Vacuolization Cytoplasmic                                     1 (4%)                                                          
   Stomach, Forestomach                               (59)         (29)         (58)                                                
      Edema                                                         1 (3%)                                                          
      Fungus                                                        1 (3%)                                                          
      Inflammation, Acute                                                        1 (2%)                                             
      Inflammation, Chronic                            2 (3%)                    1 (2%)                                             
      Inflammation, Chronic Active                     1 (2%)                                                                       
      Ulcer                                            2 (3%)       2 (7%)       1 (2%)                                             
   Stomach, Glandular                                 (58)         (31)         (59)                                                
      Atrophy                                                       1 (3%)                                                          
      Dilatation                                                    1 (3%)                                                          
      Edema                                            1 (2%)       1 (3%)                                                          
      Erosion                                                       1 (3%)                                                          
   Tooth                                                           (1)          (1)                                                 
      Peridontal Tissue, Inflammation, Acute                                     1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (60)         (29)         (59)                                                
      Cardiomyopathy                                  47 (78%)     22 (76%)     43 (73%)                                            
      Atrium, Thrombosis                               3 (5%)       1 (3%)       2 (3%)                                             
      Endocardium, Fibrosis                                                      1 (2%)                                             
      Epicardium, Fibrosis                                          1 (3%)                                                          
      Epicardium, Inflammation, Chronic                             1 (3%)       2 (3%)                                             
      Epicardium, Inflammation, Chronic Active         1 (2%)                                                                       
      Myocardium, Inflammation, Acute                                            1 (2%)                                             
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    9                                                              
NTP Experiment-Test: 05041-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 13:16:42  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     CONTROL      50MG/KG      100MG/KG                                               
                                                   MALE         LOW MALE     HIGHMALE                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (60)         (60)         (59)                                                
      Angiectasis                                                                1 (2%)                                             
      Hematopoietic Cell Proliferation                                           1 (2%)                                             
      Hyperplasia                                      6 (10%)      3 (5%)       4 (7%)                                             
      Hypertrophy, Focal                               1 (2%)       1 (2%)                                                          
      Necrosis, Focal                                  1 (2%)       1 (2%)       1 (2%)                                             
      Vacuolization Cytoplasmic, Focal                 4 (7%)       8 (13%)      3 (5%)                                             
   Adrenal Gland, Medulla                             (58)         (58)         (58)                                                
      Hyperplasia                                     21 (36%)      9 (16%)     14 (24%)                                            
      Necrosis                                                      1 (2%)                                                          
   Islets, Pancreatic                                 (59)         (27)         (60)                                                
      Hyperplasia                                      2 (3%)                    3 (5%)                                             
   Parathyroid Gland                                  (51)         (26)         (51)                                                
      Hyperplasia                                      1 (2%)                                                                       
   Pituitary Gland                                    (57)         (59)         (60)                                                
      Hemorrhage                                       1 (2%)                                                                       
      Pars Distalis, Angiectasis                       2 (4%)       3 (5%)       5 (8%)                                             
      Pars Distalis, Cyst                                           2 (3%)       2 (3%)                                             
      Pars Distalis, Hyperplasia                       8 (14%)     11 (19%)     11 (18%)                                            
      Pars Distalis, Inflammation, Chronic                          1 (2%)                                                          
      Pars Distalis, Thrombosis                                     1 (2%)                                                          
      Pars Distalis, Vacuolization Cytoplasmic                                   1 (2%)                                             
   Thyroid Gland                                      (60)         (60)         (58)                                                
      Cyst                                             2 (3%)                    2 (3%)                                             
      Fibrosis                                                      1 (2%)                                                          
      Inflammation, Chronic                            2 (3%)                                                                       
      C-Cell, Hyperplasia                             11 (18%)      6 (10%)      4 (7%)                                             
      Follicular Cell, Hyperplasia                                  1 (2%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (60)         (29)         (59)                                                
      Inflammation, Acute                                           1 (3%)                                                          
      Inflammation, Chronic                                                      1 (2%)                                             
      Serosa, Hyperplasia, Focal                       1 (2%)                                                                       
   Preputial Gland                                    (48)         (23)         (51)                                                
      Dilatation                                       1 (2%)                    1 (2%)                                             
      Hyperplasia                                      1 (2%)                    1 (2%)                                             
      Inflammation, Acute                              5 (10%)                   3 (6%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   10                                                              
NTP Experiment-Test: 05041-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 13:16:42  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     CONTROL      50MG/KG      100MG/KG                                               
                                                   MALE         LOW MALE     HIGHMALE                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Inflammation, Chronic                            1 (2%)                    1 (2%)                                             
      Metaplasia, Osseous                                                        1 (2%)                                             
   Prostate                                           (59)         (29)         (58)                                                
      Hemorrhage                                                                 1 (2%)                                             
      Hyperplasia                                      7 (12%)      3 (10%)      1 (2%)                                             
      Inflammation, Acute                              3 (5%)       1 (3%)       1 (2%)                                             
      Inflammation, Chronic                            1 (2%)                    1 (2%)                                             
      Pigmentation                                                  1 (3%)                                                          
   Testes                                             (60)         (58)         (60)                                                
      Atrophy                                                       3 (5%)       2 (3%)                                             
      Interstitial Cell, Hyperplasia                                1 (2%)       4 (7%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (60)         (28)         (59)                                                
      Fibrosis                                         1 (2%)                                                                       
      Hyperplasia                                                                1 (2%)                                             
      Hyperplasia, Reticulum Cell                      1 (2%)                                                                       
   Lymph Node                                         (60)         (29)         (60)                                                
      Mediastinal, Giant Cell, Multiple                1 (2%)                                                                       
      Mediastinal, Hemorrhage                          3 (5%)       1 (3%)                                                          
      Mediastinal, Hyperplasia                         1 (2%)                    1 (2%)                                             
   Lymph Node, Mandibular                             (50)         (28)         (51)                                                
      Cyst                                             5 (10%)      2 (7%)                                                          
      Hemorrhage                                       1 (2%)       1 (4%)       3 (6%)                                             
      Hyperplasia, Lymphoid                            4 (8%)                    3 (6%)                                             
   Spleen                                             (59)         (39)         (60)                                                
      Congestion                                                    1 (3%)       1 (2%)                                             
      Fibrosis, Focal                                  2 (3%)       5 (13%)      3 (5%)                                             
      Hematopoietic Cell Proliferation                 1 (2%)       1 (3%)       2 (3%)                                             
      Hemorrhage                                       1 (2%)       1 (3%)                                                          
      Hyperplasia, Nodular                             1 (2%)                                                                       
      Necrosis                                                                   1 (2%)                                             
      Pigmentation                                     4 (7%)       1 (3%)                                                          
   Thymus                                             (45)         (28)         (48)                                                
      Congestion                                                                 1 (2%)                                             
      Hemorrhage                                                    1 (4%)       2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (48)         (25)         (42)                                                
      Dilatation                                       5 (10%)      1 (4%)       1 (2%)                                             
      Pigmentation                                                               1 (2%)                                             
   Skin                                               (60)         (29)         (59)                                                
      Cyst Epithelial Inclusion                                     1 (3%)       2 (3%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   11                                                              
NTP Experiment-Test: 05041-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 13:16:42  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     CONTROL      50MG/KG      100MG/KG                                               
                                                   MALE         LOW MALE     HIGHMALE                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - CONT                                                                                                         
      Inflammation, Chronic Active                     1 (2%)                                                                       
      Epithelium, Hyperplasia                                       1 (3%)                                                          
      Subcutaneous Tissue, Edema                                                 1 (2%)                                             
      Subcutaneous Tissue, Inflammation, Acute                                   1 (2%)                                             
      Subcutaneous Tissue, Thrombosis                                            1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (60)         (28)         (60)                                                
      Sternum, Hemorrhage                              1 (2%)                                                                       
   Skeletal Muscle                                                 (1)          (2)                                                 
      Cyst                                                                       1 (50%)                                            
      Inflammation, Chronic                                                      1 (50%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (60)         (27)         (60)                                                
      Congestion                                                    1 (4%)                                                          
      Thrombosis, Multifocal                           2 (3%)                                                                       
      Cerebrum, Inflammation, Chronic                                            1 (2%)                                             
      Meninges, Hemorrhage                                                       1 (2%)                                             
      Meninges, Inflammation, Chronic                                            1 (2%)                                             
      Thalamus, Compression                                                      1 (2%)                                             
   Spinal Cord                                        (3)                                                                           
      Nerve, Demyelination                             1 (33%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Larynx                                             (59)         (27)         (59)                                                
      Necrosis                                                                   1 (2%)                                             
   Lung                                               (60)         (60)         (60)                                                
      Congestion                                       5 (8%)      10 (17%)     12 (20%)                                            
      Fibrosis, Focal                                  1 (2%)       2 (3%)                                                          
      Foreign Body                                                  3 (5%)       7 (12%)                                            
      Hemorrhage                                                    2 (3%)       1 (2%)                                             
      Hyperplasia                                                   1 (2%)                                                          
      Hyperplasia, Adenomatous                        10 (17%)      4 (7%)       2 (3%)                                             
      Infiltration Cellular, Histiocyte               12 (20%)     18 (30%)     11 (18%)                                            
      Inflammation, Granulomatous                                                1 (2%)                                             
      Leukocytosis                                                  1 (2%)                                                          
      Metaplasia, Osseous                              2 (3%)                                                                       
      Necrosis, Focal                                                            1 (2%)                                             
      Necrosis, Multifocal                                          1 (2%)       2 (3%)                                             
      Pigmentation                                     1 (2%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   12                                                              
NTP Experiment-Test: 05041-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 13:16:42  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     CONTROL      50MG/KG      100MG/KG                                               
                                                   MALE         LOW MALE     HIGHMALE                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Thrombosis                                                    3 (5%)                                                          
      Alveolar Epithelium, Hyperplasia                 2 (3%)                    1 (2%)                                             
      Alveolus, Fibrosis, Focal                                                  1 (2%)                                             
      Interstitium, Edema                                           1 (2%)                                                          
      Interstitium, Inflammation, Chronic                           1 (2%)       2 (3%)                                             
      Mediastinum, Hemorrhage                                                    1 (2%)                                             
   Nose                                               (58)         (59)         (59)                                                
      Inflammation, Chronic Active                     1 (2%)                                                                       
      Nasolacrimal Duct, Inflammation, Acute           2 (3%)       1 (2%)       1 (2%)                                             
      Olfactory Epithelium, Inflammation, Chronic                                1 (2%)                                             
      Sinus, Foreign Body                              1 (2%)       2 (3%)       3 (5%)                                             
      Sinus, Fungus                                    1 (2%)       7 (12%)      5 (8%)                                             
      Sinus, Hemorrhage                                             1 (2%)                                                          
      Sinus, Inflammation, Acute                       7 (12%)     11 (19%)     11 (19%)                                            
      Turbinate, Foreign Body                          1 (2%)                                                                       
      Turbinate, Inflammation, Acute                   1 (2%)                    1 (2%)                                             
      Turbinate, Inflammation, Chronic                 1 (2%)                    3 (5%)                                             
      Turbinate, Metaplasia, Squamous                                            1 (2%)                                             
   Trachea                                            (60)         (28)         (59)                                                
      Inflammation, Acute                              1 (2%)                                                                       
      Inflammation, Chronic                                                      1 (2%)                                             
      Necrosis                                                      1 (4%)       3 (5%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (8)          (8)          (8)                                                 
      Hemorrhage                                                    1 (13%)                                                         
      Capsule, Lens, Cataract                                       1 (13%)                                                         
      Lens Capsule, Cataract                           4 (50%)      4 (50%)      2 (25%)                                            
      Retina, Atrophy                                  8 (100%)     8 (100%)     5 (63%)                                            
      Sclera, Metaplasia, Osseous                      4 (50%)      4 (50%)      4 (50%)                                            
   Harderian Gland                                    (2)          (1)          (3)                                                 
      Inflammation, Chronic                                         1 (100%)                                                        
      Inflammation, Chronic, Focal                     2 (100%)                  2 (67%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (60)         (59)                                                
      Abscess                                          1 (2%)                                                                       
      Congestion                                                                 1 (2%)                                             
      Cyst                                             4 (7%)       2 (3%)       1 (2%)                                             
      Hydronephrosis                                   1 (2%)       1 (2%)                                                          
      Inflammation, Chronic                            1 (2%)                                                                       
      Inflammation, Suppurative                                     1 (2%)                                                          
      Mineralization                                   1 (2%)                    2 (3%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   13                                                              
NTP Experiment-Test: 05041-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 13:16:42  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     CONTROL      50MG/KG      100MG/KG                                               
                                                   MALE         LOW MALE     HIGHMALE                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Nephropathy                                     52 (87%)     40 (67%)     26 (44%)                                            
      Papilla, Necrosis                                1 (2%)                                                                       
      Pelvis, Dilatation                               1 (2%)                                                                       
      Pelvis, Inflammation, Acute                      1 (2%)                                                                       
      Pelvis, Mineralization                                                     1 (2%)                                             
      Renal Tubule, Atrophy, Diffuse                                1 (2%)                                                          
      Renal Tubule, Pigmentation                       1 (2%)                    2 (3%)                                             
   Ureter                                             (1)                                                                           
      Inflammation, Acute                              1 (100%)                                                                     
   Urinary Bladder                                    (59)         (27)         (59)                                                
      Hemorrhage                                       2 (3%)                    1 (2%)                                             
      Inflammation, Acute                              1 (2%)                                                                       
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   14                                                              
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                             ----------              END OF REPORT             ----------                                           
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