National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/3472

TR 373 Rat Pathology Tables

NTP Experiment-Test: 05041-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 05/01/97
Route: GAVAGE                                                                                                     Time: 10:44:04




       Facility:  Microbiological Associates

       Chemical CAS #:  108-30-5

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All




































Note:  Animals arranged according to CID number

                                                              Page   1

NTP Experiment-Test: 05041-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 10:44:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 5| 6| 7| 7| 6| 5| 7| 7| 7| 5| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 2| 2| 2| 9| 7| 0| 1| 2| 4| 0| 2| 2| 2| 1| 6| 2| 2| 2| 2| 2| 3| 3| 3| 0| 4|             
                                           | 9| 3| 9| 5| 6| 4| 1| 9| 0| 7| 9| 9| 9| 6| 9| 9| 9| 9| 9| 9| 0| 0| 0| 5| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    CONTROL                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  A  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma, Extension            |             X                                                            |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma, Extension            |             X                                                            |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  M  A  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  A  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  A  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma, Extension            |             X                                                            |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  M  +  +  +  +  A  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  M  +  +  +  +  A  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma, Extension            |             X                                                            |             
      Leukemia Mononuclear                 |          X                    X              X  X                    X   |             
      Neoplastic Nodule                    |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               | +        +  +                                                        +   |             
      Adenocarcinoma, Extension            |             X                                                            |             
      Leukemia Mononuclear                 |                                                                          |             
      Sarcoma, Metastatic, Skeletal Muscle |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma, Extension            |             X                                                            |             
      Leukemia Mononuclear                 |                                                                      X   |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                           +                              |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma, Extension            |             X                                                            |             
      Adenoma, Multiple                    |                                                                          |             
      Leukemia Mononuclear                 |                                                 X                    X   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X                                                               |             
      Pheochromocytoma Malignant           |                                                                          |             
      Pheochromocytoma Benign              |                                                                   X      |             
      Pheochromocytoma Benign, Multiple    |                      X                                                   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05041-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 10:44:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 5| 6| 7| 7| 6| 5| 7| 7| 7| 5| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 2| 2| 2| 9| 7| 0| 1| 2| 4| 0| 2| 2| 2| 1| 6| 2| 2| 2| 2| 2| 3| 3| 3| 0| 4|             
                                           | 9| 3| 9| 5| 6| 4| 1| 9| 0| 7| 9| 9| 9| 6| 9| 9| 9| 9| 9| 9| 0| 0| 0| 5| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    CONTROL                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  M  +  +  +  M  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               | X  X  X        X  X     X     X  X                 X     X  X     X  X   |             
      Pars Distalis, Adenoma, Multiple     |                                                                X         |             
      Pars Distalis, Carcinoma             |                                                                          |             
      Pars Distalis, Leukemia Mononuclear  |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Adenoma                      |                      X                          X                        |             
      C-Cell, Carcinoma                    |                                                                          |             
      Follicular Cell, Carcinoma           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  M  +  +  M  +  M  +  +  +  M  M  +  +  +  +  M  +  M  M  M  +  +  +  +|             
      Adenoma                              |                                                                         X|             
      Squamous Cell Papilloma, Multiple    |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma, Metastatic, Uterus   |             X                                                            |             
      Leukemia Mononuclear                 |          X                                      X                        |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma                       |             X                                                            |             
      Leukemia Mononuclear                 |                                                                          |             
      Sarcoma                              |                X                                                         |             
      Endometrium, Polyp Stromal           | X                                X  X        X        X        X         |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma, Metastatic, Uterus   |             X                                                            |             
      Mediastinal, Leukemia Mononuclear    |          X                                                           X   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                      X   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X                    X              X  X                    X   |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  M  +  +  M  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05041-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 10:44:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 5| 6| 7| 7| 6| 5| 7| 7| 7| 5| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 2| 2| 2| 9| 7| 0| 1| 2| 4| 0| 2| 2| 2| 1| 6| 2| 2| 2| 2| 2| 3| 3| 3| 0| 4|             
                                           | 9| 3| 9| 5| 6| 4| 1| 9| 0| 7| 9| 9| 9| 6| 9| 9| 9| 9| 9| 9| 0| 0| 0| 5| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    CONTROL                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                            X                                             |             
      Fibroadenoma                         |                X  X     X                                X     X  X  X   |             
      Fibroadenoma, Multiple               |             X                                         X                  |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Head, Sebaceous Gland, Adenoma       |                                     X                                    |             
      Subcutaneous Tissue, Lipoma          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Sarcoma                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma                            |                                                                          |             
      Leukemia Mononuclear                 |                                                 X                        |             
      Oligodendroglioma Benign             |                   X                                                      |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                 +                        |             
      Leukemia Mononuclear                 |                                                 X                        |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma, Metastatic, Uterus   |             X                                                            |             
      Alveolar/Bronchiolar Adenoma         |                                                                          |             
      Leukemia Mononuclear                 |          X                                      X                    X   |             
      Sarcoma, Metastatic, Skeletal Muscle |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |    A                                            +                        |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
      Squamous Cell Carcinoma              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                 X                    X   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X                    X              X  X                    X   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05041-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 10:44:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 6| 5| 0| 7| 7| 7| 6| 4|             
                             DAY ON TEST   | 2| 3| 3| 1| 1| 7| 3| 3| 1| 1| 3| 3| 3| 3| 2| 3| 3| 0| 5| 7| 3| 3| 0| 4| 9|             
                                           | 6| 0| 0| 5| 6| 0| 0| 0| 9| 1| 0| 0| 0| 0| 0| 0| 0| 6| 3| 7| 0| 0| 5| 2| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    CONTROL                                | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  A  +|             
      Adenocarcinoma, Extension            |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
      Adenocarcinoma, Extension            |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
      Adenocarcinoma, Extension            |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma, Extension            |                                                                          |             
      Leukemia Mononuclear                 |             X  X                                   X                    X|             
      Neoplastic Nodule                    |                                     X                                    |             
                                            __________________________________________________________________________|             
   Mesentery                               |          +                                         +                     |             
      Adenocarcinoma, Extension            |                                                                          |             
      Leukemia Mononuclear                 |                                                    X                     |             
      Sarcoma, Metastatic, Skeletal Muscle |          X                                                               |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma, Extension            |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                X                                                        X|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma, Extension            |                                                                          |             
      Adenoma, Multiple                    |                      X                                                   |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                    X                     |             
      Pheochromocytoma Malignant           |                                                                          |             
      Pheochromocytoma Benign              | X                                                                        |             
      Pheochromocytoma Benign, Multiple    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05041-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 10:44:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 6| 5| 0| 7| 7| 7| 6| 4|             
                             DAY ON TEST   | 2| 3| 3| 1| 1| 7| 3| 3| 1| 1| 3| 3| 3| 3| 2| 3| 3| 0| 5| 7| 3| 3| 0| 4| 9|             
                                           | 6| 0| 0| 5| 6| 0| 0| 0| 9| 1| 0| 0| 0| 0| 0| 0| 0| 6| 3| 7| 0| 0| 5| 2| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    CONTROL                                | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  M  M  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  M  +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               |    X  X  X  X  X  X     X  X                 X  X     X           X  X   |             
      Pars Distalis, Adenoma, Multiple     |                               X        X                                 |             
      Pars Distalis, Carcinoma             |                                                                          |             
      Pars Distalis, Leukemia Mononuclear  |             X  X                                                         |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Adenoma                      |                                                                         X|             
      C-Cell, Carcinoma                    |    X                 X                                         X         |             
      Follicular Cell, Carcinoma           |                                                                   X      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  M  M  +  +  +  M  +  M  +  M  M  +  +  M  +  +  M  +  +  +  M  M|             
      Adenoma                              |                                  X                                       |             
      Squamous Cell Papilloma, Multiple    |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Adenocarcinoma, Metastatic, Uterus   |                                                                          |             
      Leukemia Mononuclear                 |                X                                                         |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Adenocarcinoma                       |                                                                          |             
      Leukemia Mononuclear                 |                                                    X                     |             
      Sarcoma                              |                                                                          |             
      Endometrium, Polyp Stromal           | X     X           X              X                                       |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X                                                            |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma, Metastatic, Uterus   |                                                                          |             
      Mediastinal, Leukemia Mononuclear    |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X  X                                                         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X  X                                   X                     |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X  X                                   X                    X|             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +|             
      Leukemia Mononuclear                 |                X                                                         |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   6                                                               
NTP Experiment-Test: 05041-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 10:44:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 6| 5| 0| 7| 7| 7| 6| 4|             
                             DAY ON TEST   | 2| 3| 3| 1| 1| 7| 3| 3| 1| 1| 3| 3| 3| 3| 2| 3| 3| 0| 5| 7| 3| 3| 0| 4| 9|             
                                           | 6| 0| 0| 5| 6| 0| 0| 0| 9| 1| 0| 0| 0| 0| 0| 0| 0| 6| 3| 7| 0| 0| 5| 2| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    CONTROL                                | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Fibroadenoma                         | X        X        X           X              X        X        X         |             
      Fibroadenoma, Multiple               |                         X           X  X                    X        X   |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Head, Sebaceous Gland, Adenoma       |                                                                          |             
      Subcutaneous Tissue, Lipoma          |                                                 X                        |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |          +                                                               |             
      Sarcoma                              |          X                                                               |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma                            |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
      Oligodendroglioma Benign             |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma, Metastatic, Uterus   |                                                                          |             
      Alveolar/Bronchiolar Adenoma         |                      X  X                                                |             
      Leukemia Mononuclear                 |             X  X                                   X                    X|             
      Sarcoma, Metastatic, Skeletal Muscle |          X                                                               |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |    +                                                     +               |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                           +                              |             
      Squamous Cell Carcinoma              |                                           X                              |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                X                                   X                     |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X  X                                   X                    X|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   7                                                               
NTP Experiment-Test: 05041-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 10:44:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 4| 0| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 3| 6| 7| 0| 2| 3| 3| 3| 0|                                            |            |
                                           | 0| 0| 3| 9| 9| 3| 0| 0| 0| 7|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |     A      |
    CONTROL                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |     L      |
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  A  +  +  +  +  A                                             |  56        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  A  +  +  +  +  A                                             |  54        |
      Adenocarcinoma, Extension            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  A  +  +  +  +  A                                             |  55        |
      Adenocarcinoma, Extension            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  A  +  +  +  +  A                                             |  53        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  A  +  +  +  +  A                                             |  56        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  A  +  +  +  +  A                                             |  55        |
      Adenocarcinoma, Extension            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  A  +  +  +  +  A                                             |  53        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  A  +  +  +  +  A                                             |  53        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Adenocarcinoma, Extension            |                                                                          |          1 |
      Leukemia Mononuclear                 |    X              X                                                      |         11 |
      Neoplastic Nodule                    |                   X                                                      |          2 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   6        |
      Adenocarcinoma, Extension            |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Sarcoma, Metastatic, Skeletal Muscle |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  A  +  +  +  +  +                                             |  59        |
      Adenocarcinoma, Extension            |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  A  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  A  +  +  +  +  +                                             |  58        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  A  +  +  +  +  +                                             |  58        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Adenocarcinoma, Extension            |                                                                          |          1 |
      Adenoma, Multiple                    |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |          2 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page   8                                                               
NTP Experiment-Test: 05041-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 10:44:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 4| 0| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 3| 6| 7| 0| 2| 3| 3| 3| 0|                                            |            |
                                           | 0| 0| 3| 9| 9| 3| 0| 0| 0| 7|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |     A      |
    CONTROL                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |     L      |
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Leukemia Mononuclear                 |                                                                          |          2 |
      Pheochromocytoma Malignant           |                         X                                                |          1 |
      Pheochromocytoma Benign              |                                                                          |          2 |
      Pheochromocytoma Benign, Multiple    |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  M  A  M  +  +  +  +                                             |  46        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Pars Distalis, Adenoma               |                X                                                         |         27 |
      Pars Distalis, Adenoma, Multiple     |                                                                          |          3 |
      Pars Distalis, Carcinoma             | X                                                                        |          1 |
      Pars Distalis, Leukemia Mononuclear  |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  A  +  +  +  +  +                                             |  59        |
      C-Cell, Adenoma                      | X  X                                                                     |          5 |
      C-Cell, Carcinoma                    |                         X                                                |          4 |
      Follicular Cell, Carcinoma           |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | M  +  +  +  A  +  +  +  +  +                                             |  39        |
      Adenoma                              |                                                                          |          2 |
      Squamous Cell Papilloma, Multiple    |          X                                                               |          1 |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Adenocarcinoma, Metastatic, Uterus   |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Adenocarcinoma                       |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Sarcoma                              |                                                                          |          1 |
      Endometrium, Polyp Stromal           |       X                                                                  |         11 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  M  +  +  +  +  +  +                                             |  59        |
      Adenocarcinoma, Metastatic, Uterus   |                                                                          |          1 |
      Mediastinal, Leukemia Mononuclear    |                                                                          |          2 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page   9                                                               
NTP Experiment-Test: 05041-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 10:44:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 4| 0| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 3| 6| 7| 0| 2| 3| 3| 3| 0|                                            |            |
                                           | 0| 0| 3| 9| 9| 3| 0| 0| 0| 7|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |     A      |
    CONTROL                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |     L      |
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  M  +  +  +  +  +  M                                             |  54        |
      Leukemia Mononuclear                 |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  M  +  +  +  +  +  +                                             |  59        |
      Leukemia Mononuclear                 |                                                                          |          4 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  A  +  +  +  +  +                                             |  59        |
      Leukemia Mononuclear                 |    X              X                                                      |         11 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  M  +  +  M  +  +  +  +                                             |  48        |
      Leukemia Mononuclear                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  M  +  +  +  +  +  +                                             |  59        |
      Adenoma                              |                                                                          |          1 |
      Fibroadenoma                         | X              X           X                                             |         17 |
      Fibroadenoma, Multiple               |    X                                                                     |          8 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Head, Sebaceous Gland, Adenoma       |                                                                          |          1 |
      Subcutaneous Tissue, Lipoma          |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
      Sarcoma                              |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Carcinoma                            | X                                                                        |          1 |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Oligodendroglioma Benign             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
      Leukemia Mononuclear                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  M  +                                             |  58        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Adenocarcinoma, Metastatic, Uterus   |                                                                          |          1 |
      Alveolar/Bronchiolar Adenoma         |                         X                                                |          3 |
      Leukemia Mononuclear                 |                                                                          |          7 |
      Sarcoma, Metastatic, Skeletal Muscle |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  A  +  +  +  +  +                                             |  59        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  10                                                               
NTP Experiment-Test: 05041-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 10:44:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 4| 0| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 3| 6| 7| 0| 2| 3| 3| 3| 0|                                            |            |
                                           | 0| 0| 3| 9| 9| 3| 0| 0| 0| 7|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |     A      |
    CONTROL                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |     L      |
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |             +                                                            |   1        |
                                            __________________________________________________________________________|____________|
   Eye                                     |          +                                                               |   4        |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
      Squamous Cell Carcinoma              |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |                                                                          |          4 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  M  +  +  +                                             |  56        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |    X              X                                                      |         11 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  11                                                               
NTP Experiment-Test: 05041-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 10:44:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 4| 0| 0| 7| 0| 0| 0| 0| 7| 7| 7| 7| 0| 7| 6| 6| 1| 0| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 9| 0| 0| 0| 3| 1| 1| 0| 0| 3| 3| 3| 0| 1| 3| 9| 8| 6| 0| 3| 3| 3| 3| 3|             
                                           | 1| 0| 1| 5| 2| 1| 3| 0| 9| 9| 1| 1| 1| 5| 2| 1| 1| 4| 9| 2| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    50 MG/KG                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
     LOW FEM                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +  +  +  +     +  +  +  +           +  +  +  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Intestine Large                         |    +  +  +  +     +  +  +  +           +  +  +  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    +  +  M  M     M  M  M  M           +  M  +  +  +  +  M               |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +  +  +  +     +  +  +  +           +  +  +  +  +  +  +               |             
      Sarcoma Stromal, Metastatic, Uterus  |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +  +  M  M     M  M  M  M           +  M  +  +  +  +  M               |             
                                            __________________________________________________________________________|             
   Intestine Small                         |    +  +  +  +     +  +  +  +           +  +  +  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +  +  +  +     +  +  +  +           +  +  +  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    +  +  M  M     M  M  M  M           +  M  +  +  +  +  M               |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +  +  M  M     M  M  M  M           +  M  +  +  +  +  M               |             
                                            __________________________________________________________________________|             
   Liver                                   |    +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +     +      |             
      Leukemia Mononuclear                 |                                        X                                 |             
      Neoplastic Nodule                    |                                                             X            |             
                                            __________________________________________________________________________|             
   Mesentery                               | +     +           +                                                      |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +  +  +  +     +  +  +  +           +  +  +  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +  +  +  +     +  +  +  +           +  +  +  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Stomach                                 |    +  +  +  +     +  +  +  +           +  +  +  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +  +  +  +     +  +  +  +           +  +  +  +  +  +  +               |             
      Squamous Cell Papilloma              |                                              X                           |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +  +  +  +     +  +  +  +           +  +  +  +  +  +  +               |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |    +  +  +  +     +  +  +  +           +  +  +  +  +  +  +               |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +     +  +  +  +           +  +  +  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +     +  +  +  +           +  +  +  +  +  +  +               |             
      Carcinoma                            | X                                                                        |             
      Leukemia Mononuclear                 |                                        X                                 |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |    +  +  +  +     +  +  +  +           +  +  +  +  +  +  +               |             
      Pheochromocytoma Benign              |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +  +  +  +     +  +  +  +           +  +  +  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    M  +  M  M     +  +  +  +           +  +  +  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
      Pars Distalis, Adenoma               |                X                 X  X  X        X  X           X         |             
      Pars Distalis, Adenoma, Multiple     |                                                                          |             
      Pars Distalis, Leukemia Mononuclear  |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |    +  +  +  +     +  +  +  +  +        +  +  +  +  +  +  +               |             
      C-Cell, Adenoma                      |                                                                          |             
      C-Cell, Carcinoma                    |                               X                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  12                                                               
NTP Experiment-Test: 05041-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 10:44:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 4| 0| 0| 7| 0| 0| 0| 0| 7| 7| 7| 7| 0| 7| 6| 6| 1| 0| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 9| 0| 0| 0| 3| 1| 1| 0| 0| 3| 3| 3| 0| 1| 3| 9| 8| 6| 0| 3| 3| 3| 3| 3|             
                                           | 1| 0| 1| 5| 2| 1| 3| 0| 9| 9| 1| 1| 1| 5| 2| 1| 1| 4| 9| 2| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    50 MG/KG                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
     LOW FEM                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |    +  M  M  M     M  M  M  M           +  M  M  +  +  M  M           +   |             
      Adenoma                              |    X                                            X                        |             
                                            __________________________________________________________________________|             
   Ovary                                   |    +  +  +  +     +  +  +  +           +  +  +  +  +  +  +               |             
      Luteoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +     +  +  +  +  +        +  +  +  +  +  +  +               |             
      Hemangiosarcoma                      |                                                                          |             
      Leiomyosarcoma                       |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
      Endometrium, Polyp Stromal           |                                                                          |             
      Endometrium, Sarcoma Stromal         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +  +  +  +     +  +  +  +           +  +  +  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +  +  +  +     +  +  +  +           +  +  +  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |    +  +  +  +     +  +  +  M           +  +  +  +  +  +  +               |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |    +  +  +  +     M  +  +  +           +  +  +  +  +  M  +               |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  |    +  +  +  +     M  +  +  +           +  +  +  +  +  +  +               |             
      Leukemia Mononuclear                 |                                        X                                 |             
                                            __________________________________________________________________________|             
   Thymus                                  |    +  +  +  +     +  +  +  +           +  +  +  +  +  +  +               |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  M  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma                       |                                                                          |             
      Adenoma                              |                                                                          |             
      Fibroadenoma                         |                               X                    X        X     X  X  X|             
      Fibroadenoma, Multiple               |                                     X        X                           |             
                                            __________________________________________________________________________|             
   Skin                                    |    +  +  +  +     +  +  +  +           +  +  +  +  +  +  +               |             
      Sarcoma                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +  +  +  +     +  +  +  +           +  +  +  +  +  +  +               |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +  +  +  +     +  +  +  +           +  +  +  +  +  +  +               |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  |    +  +  +  +     +  +  +  +           +  +  +  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +     +  +  +  +           +  +  +  +  +  +  +  +            |             
      Alveolar/Bronchiolar Adenoma         | X                                                                        |             
      Leukemia Mononuclear                 |                                        X                                 |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  M  M  +  M  M  M  M  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  13                                                               
NTP Experiment-Test: 05041-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 10:44:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 4| 0| 0| 7| 0| 0| 0| 0| 7| 7| 7| 7| 0| 7| 6| 6| 1| 0| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 9| 0| 0| 0| 3| 1| 1| 0| 0| 3| 3| 3| 0| 1| 3| 9| 8| 6| 0| 3| 3| 3| 3| 3|             
                                           | 1| 0| 1| 5| 2| 1| 3| 0| 9| 9| 1| 1| 1| 5| 2| 1| 1| 4| 9| 2| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    50 MG/KG                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
     LOW FEM                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 |    +  +  +  +     +  +  +  +           +  +  +  +  +  +  +               |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                +     +                                            +      |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                   +                                                      |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Nephroblastoma                       |       X                                               X                  |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    +  +  +  +     +  +  M  +           +  M  +  +  +  +  +               |             
      Leiomyosarcoma                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                        X                                 |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  14                                                               
NTP Experiment-Test: 05041-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 10:44:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 6| 5| 7| 7| 6| 6| 5| 4| 7| 7| 7| 6| 7| 7| 7| 6| 0| 7| 7| 7| 6| 6|             
                             DAY ON TEST   | 1| 3| 3| 8| 9| 2| 3| 7| 0| 4| 7| 3| 3| 3| 2| 2| 3| 3| 0| 1| 3| 3| 3| 9| 0|             
                                           | 7| 1| 1| 9| 9| 3| 2| 7| 6| 1| 1| 2| 2| 2| 0| 3| 2| 2| 3| 1| 2| 2| 2| 5| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    50 MG/KG                               | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
     LOW FEM                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +        +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +        +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +        +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  M  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +        +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  A  +  +  +  +  +|             
      Sarcoma Stromal, Metastatic, Uterus  |                                                                      X   |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +        +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  M  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +        +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +        +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +        +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  M  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +        +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  M  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X                          X           X              X      |             
      Neoplastic Nodule                    |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                +         |             
                                            __________________________________________________________________________|             
   Pancreas                                | +        +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +        +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +        +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +        +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  M  +  +  +  +  +|             
      Squamous Cell Papilloma              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +        +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +        +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +        +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +        +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  M  +  +  +  +  +|             
      Carcinoma                            |                                                                          |             
      Leukemia Mononuclear                 |                                                    X              X      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +        +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  M  +  +  +  +  +|             
      Pheochromocytoma Benign              |                   X                                                      |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +        +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +        +  M  +  +  +  +  +  +  +  +     +  +  +  +  +  M  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |    +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               |    X     X     X  X           X     X  X  X  X  X           X  X  X     X|             
      Pars Distalis, Adenoma, Multiple     |                                                                          |             
      Pars Distalis, Leukemia Mononuclear  |                                        X                                 |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +        +  M  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Adenoma                      |                                                                          |             
      C-Cell, Carcinoma                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  15                                                               
NTP Experiment-Test: 05041-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 10:44:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 6| 5| 7| 7| 6| 6| 5| 4| 7| 7| 7| 6| 7| 7| 7| 6| 0| 7| 7| 7| 6| 6|             
                             DAY ON TEST   | 1| 3| 3| 8| 9| 2| 3| 7| 0| 4| 7| 3| 3| 3| 2| 2| 3| 3| 0| 1| 3| 3| 3| 9| 0|             
                                           | 7| 1| 1| 9| 9| 3| 2| 7| 6| 1| 1| 2| 2| 2| 0| 3| 2| 2| 3| 1| 2| 2| 2| 5| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    50 MG/KG                               | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
     LOW FEM                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +     M  +  +  +  +  +  +  M  +  +     M  +  +  +  M  M  +  M  +  +  M|             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +        +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Luteoma                              |                            X                                             |             
                                            __________________________________________________________________________|             
   Uterus                                  | +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                      X                                                   |             
      Leiomyosarcoma                       |                                        X                                 |             
      Leukemia Mononuclear                 |                                        X                                 |             
      Endometrium, Polyp Stromal           |             X        X     X     X           X                    X      |             
      Endometrium, Sarcoma Stromal         |                                                                      X   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +        +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +        +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +        +  M  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                   X      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +        +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                    X                     |             
                                            __________________________________________________________________________|             
   Spleen                                  | +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X                          X           X              X      |             
                                            __________________________________________________________________________|             
   Thymus                                  | +        +  +  +  M  +  M  +  +  +  +     M  +  +  +  +  +  +  +  M  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +|             
      Adenocarcinoma                       |                                           X                              |             
      Adenoma                              |                                                                         X|             
      Fibroadenoma                         | X  X  X              X  X                 X  X  X     X                  |             
      Fibroadenoma, Multiple               |          X        X                    X                          X      |             
                                            __________________________________________________________________________|             
   Skin                                    | +        +  +  +  +  +  +  +  +  +  +     +  +  +  +  M  +  +  +  +  +  +|             
      Sarcoma                              |                      X                                                   |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +        +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +        +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +        +  M  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                                                          |             
      Leukemia Mononuclear                 |                                        X           X              X      |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  16                                                               
NTP Experiment-Test: 05041-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 10:44:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 6| 5| 7| 7| 6| 6| 5| 4| 7| 7| 7| 6| 7| 7| 7| 6| 0| 7| 7| 7| 6| 6|             
                             DAY ON TEST   | 1| 3| 3| 8| 9| 2| 3| 7| 0| 4| 7| 3| 3| 3| 2| 2| 3| 3| 0| 1| 3| 3| 3| 9| 0|             
                                           | 7| 1| 1| 9| 9| 3| 2| 7| 6| 1| 1| 2| 2| 2| 0| 3| 2| 2| 3| 1| 2| 2| 2| 5| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    50 MG/KG                               | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
     LOW FEM                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +        +  M  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                +           +  +                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X                          X                                 |             
      Nephroblastoma                       |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +     +  M  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Leiomyosarcoma                       |       X                                                                  |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X                          X           X              X      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  17                                                               
NTP Experiment-Test: 05041-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 10:44:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 1| 7| 6| 7| 7| 0|                                            |            |
                             DAY ON TEST   | 2| 3| 3| 2| 8| 3| 4| 3| 3| 0|                                            |            |
                                           | 3| 2| 2| 3| 7| 2| 2| 2| 2| 9|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |     A      |
    50 MG/KG                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |     L      |
     LOW FEM                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +     +  +  +     +  +  +  +                                             |  45        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +     +  +  +     +  +  +  +                                             |  45        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +     +  +  +     +  +  +  M                                             |  35        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +     +  +  +     +  +  +  +                                             |  44        |
      Sarcoma Stromal, Metastatic, Uterus  |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +     +  +  +     +  +  +  M                                             |  35        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +     +  +  +     +  +  +  +                                             |  45        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +     +  +  +     +  +  +  +                                             |  44        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +     +  +  +     +  +  +  M                                             |  35        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +     +  +  +     +  +  +  M                                             |  35        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +     +  +  +  +                                             |  52        |
      Leukemia Mononuclear                 |                                                                          |          5 |
      Neoplastic Nodule                    |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |          +  +                                                            |   6        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +     +  +  +     +  +  +  +                                             |  44        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +     +  +  +     +  +  +  +                                             |  45        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +     +  +  +     +  +  +  +                                             |  45        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +     +  +  +     +  +  +  +                                             |  44        |
      Squamous Cell Papilloma              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +     +  +  +     +  +  +  +                                             |  45        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +     +  +  +     +  +  +  +                                             |  45        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +     +  +  +     +  +  +  +                                             |  46        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +     +  +  +     +  +  +  +                                             |  45        |
      Carcinoma                            |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |       +  +  +     +  +  +  +                                             |  43        |
      Pheochromocytoma Benign              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +     +  +  +     +  +  +  +                                             |  44        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +     +  M  +     +  +  +  +                                             |  38        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +     +  +  +  +  +  +  +  +                                             |  55        |
      Pars Distalis, Adenoma               | X        X        X     X                                                |         25 |
      Pars Distalis, Adenoma, Multiple     |                      X                                                   |          1 |
      Pars Distalis, Leukemia Mononuclear  |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +     +  +  +     +  +  +  +                                             |  45        |
      C-Cell, Adenoma                      |          X           X                                                   |          2 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  18                                                               
NTP Experiment-Test: 05041-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 10:44:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 1| 7| 6| 7| 7| 0|                                            |            |
                             DAY ON TEST   | 2| 3| 3| 2| 8| 3| 4| 3| 3| 0|                                            |            |
                                           | 3| 2| 2| 3| 7| 2| 2| 2| 2| 9|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |     A      |
    50 MG/KG                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |     L      |
     LOW FEM                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      C-Cell, Carcinoma                    |          X                                                               |          2 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +     M  +  +     +  +  +  M                                             |  27        |
      Adenoma                              |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Ovary                                   |       +  +  +     +  +  +  +                                             |  44        |
      Luteoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +     +  +  +     +  +  +  +                                             |  48        |
      Hemangiosarcoma                      |                                                                          |          1 |
      Leiomyosarcoma                       |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Endometrium, Polyp Stromal           | X                       X                                                |          8 |
      Endometrium, Sarcoma Stromal         |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +     +  +  +     +  +  +  +                                             |  45        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +     +  +  +     +  +  +  +                                             |  45        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +     +  +  +     +  +  +  +                                             |  43        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +     +  +  +     +  +  +  +                                             |  43        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +     +  +  +  +  +  +  +  +                                             |  46        |
      Leukemia Mononuclear                 |                X                                                         |          6 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +     +  +  +     +  +  +  +                                             |  41        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  55        |
      Adenocarcinoma                       |          X                                                               |          2 |
      Adenoma                              |                   X                                                      |          2 |
      Fibroadenoma                         | X        X                                                               |         17 |
      Fibroadenoma, Multiple               |                                                                          |          6 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +     +  +  +     +  +  +  +                                             |  44        |
      Sarcoma                              |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +     +  +  +     +  +  +  +                                             |  45        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  19                                                               
NTP Experiment-Test: 05041-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 10:44:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 1| 7| 6| 7| 7| 0|                                            |            |
                             DAY ON TEST   | 2| 3| 3| 2| 8| 3| 4| 3| 3| 0|                                            |            |
                                           | 3| 2| 2| 3| 7| 2| 2| 2| 2| 9|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |     A      |
    50 MG/KG                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |     L      |
     LOW FEM                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +     +  +  +     +  +  +  +                                             |  45        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +     +  +  +     +  +  +  +                                             |  44        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +     +  +  +  +  +  +  +  +                                             |  49        |
      Alveolar/Bronchiolar Adenoma         |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |          4 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  M                                             |  50        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +     +  +  +     +  +  +  +                                             |  44        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |    +     +                                                               |   8        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +     +  +  +  +  +  +                                             |  59        |
      Leukemia Mononuclear                 |                                                                          |          2 |
      Nephroblastoma                       |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |       +  +  +        +  +  +                                             |  41        |
      Leiomyosarcoma                       |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |                X                                                         |          6 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  20                                                               
NTP Experiment-Test: 05041-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 10:44:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 7| 7| 7| 7| 7| 5| 2| 7| 7| 7| 7| 0| 7| 7| 6| 3| 1| 7| 1| 1| 3| 3|             
                             DAY ON TEST   | 3| 1| 0| 3| 0| 3| 2| 1| 6| 2| 3| 3| 3| 3| 0| 3| 2| 2| 5| 9| 3| 7| 7| 3| 6|             
                                           | 1| 9| 6| 2| 5| 2| 0| 1| 3| 5| 2| 2| 2| 2| 9| 2| 0| 5| 3| 8| 2| 6| 0| 7| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    100MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     HIGHFEM                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X  X                                                                  |             
      Neoplastic Nodule                    |                                                                          |             
      Neoplastic Nodule, Multiple          |                                                             X            |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                     +                    +               |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X                                                                  |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X                                                                  |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  M  +  +  +  +  +     +  +  M  +  +  +  +  M  M  +|             
      Pheochromocytoma Benign              |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  M  +  M  +  +  M  +  +  M  +  +  +  M  +  M  +  +  M  +  +  +  M  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               | X        X  X  X                    X           X  X        X        X   |             
      Pars Distalis, Adenoma, Multiple     |                                  X                                       |             
      Pars Distalis, Carcinoma             |                      X                                                   |             
      Pars Distalis, Leukemia Mononuclear  |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Adenoma                      |                               X                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  21                                                               
NTP Experiment-Test: 05041-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 10:44:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 7| 7| 7| 7| 7| 5| 2| 7| 7| 7| 7| 0| 7| 7| 6| 3| 1| 7| 1| 1| 3| 3|             
                             DAY ON TEST   | 3| 1| 0| 3| 0| 3| 2| 1| 6| 2| 3| 3| 3| 3| 0| 3| 2| 2| 5| 9| 3| 7| 7| 3| 6|             
                                           | 1| 9| 6| 2| 5| 2| 0| 1| 3| 5| 2| 2| 2| 2| 9| 2| 0| 5| 3| 8| 2| 6| 0| 7| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    100MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     HIGHFEM                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      C-Cell, Carcinoma                    |                                                                          |             
      Follicular Cell, Adenoma             |                                                    X                     |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X                                                                  |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Skin                            |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Sarcoma Stromal                      |                                                                          |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Skin                            |                                                                          |             
      Endometrium, Polyp Stromal           |       X           X                                                      |             
      Endometrium, Polyp Stromal, Multiple |                                     X                                    |             
      Endometrium, Sarcoma Stromal         |          X                                                               |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X                                                                  |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mediastinal, Leukemia Mononuclear    |       X                                                                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Leukemia Mononuclear                 |       X                                                                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X                                                                  |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X  X                                                                  |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  M  +  +  M  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Leukemia Mononuclear                 |                                                                          |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Skin                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma                       | X                                                                        |             
      Fibroadenoma                         |             X     X  X        X                 X           X            |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Squamous Cell Carcinoma              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  22                                                               
NTP Experiment-Test: 05041-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 10:44:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 7| 7| 7| 7| 7| 5| 2| 7| 7| 7| 7| 0| 7| 7| 6| 3| 1| 7| 1| 1| 3| 3|             
                             DAY ON TEST   | 3| 1| 0| 3| 0| 3| 2| 1| 6| 2| 3| 3| 3| 3| 0| 3| 2| 2| 5| 9| 3| 7| 7| 3| 6|             
                                           | 1| 9| 6| 2| 5| 2| 0| 1| 3| 5| 2| 2| 2| 2| 9| 2| 0| 5| 3| 8| 2| 6| 0| 7| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    100MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     HIGHFEM                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Subcutaneous Tissue, Fibroma         |                                                                          |             
      Subcutaneous Tissue, Fibrosarcoma    |                                                 X                        |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                          +               |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Astrocytoma Benign                   |                                                                          |             
      Ependymoma Benign                    |                                                                      X   |             
      Leukemia Mononuclear                 |       X                                                                  |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X  X                                                                  |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Skin                            |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                +                    +                                    |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X                                                                  |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Skin                            |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X  X                                                                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  23                                                               
NTP Experiment-Test: 05041-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 10:44:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 1| 0| 0| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 5| 2| 7| 7| 6| 6| 2|             
                             DAY ON TEST   | 3| 7| 1| 0| 0| 3| 3| 3| 3| 0| 3| 3| 2| 2| 3| 3| 3| 7| 8| 8| 3| 3| 6| 0| 0|             
                                           | 2| 4| 1| 9| 5| 2| 2| 2| 2| 3| 2| 2| 6| 6| 2| 2| 2| 8| 6| 3| 2| 2| 3| 6| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    100MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
     HIGHFEM                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  M  M  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  M  M  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  A  +  M  A  +  +  +  +  A  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  A  +  M  A  +  +  +  +  A  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  A  M  M  A  +  +  +  +  A  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                   X                                                      |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  A  M  M  A  +  +  +  +  A  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                X  X           X     X  X     X                           |             
      Neoplastic Nodule                    |                X                                                         |             
      Neoplastic Nodule, Multiple          |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                   X                    X                                 |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                        X                                 |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                   X                 X  X                                 |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  A  +  +     +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                   X                                                      |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                        X                                 |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                   X                 X  X                                 |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Pheochromocytoma Benign              |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               | X  X           X        X        X     X           X  X                  |             
      Pars Distalis, Adenoma, Multiple     |                      X                                                   |             
      Pars Distalis, Carcinoma             |                                                                          |             
      Pars Distalis, Leukemia Mononuclear  |                   X                    X                                 |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Adenoma                      |                X              X                                   X      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  24                                                               
NTP Experiment-Test: 05041-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 10:44:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 1| 0| 0| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 5| 2| 7| 7| 6| 6| 2|             
                             DAY ON TEST   | 3| 7| 1| 0| 0| 3| 3| 3| 3| 0| 3| 3| 2| 2| 3| 3| 3| 7| 8| 8| 3| 3| 6| 0| 0|             
                                           | 2| 4| 1| 9| 5| 2| 2| 2| 2| 3| 2| 2| 6| 6| 2| 2| 2| 8| 6| 3| 2| 2| 3| 6| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    100MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
     HIGHFEM                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      C-Cell, Carcinoma                    |                                  X                                       |             
      Follicular Cell, Adenoma             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  M  M  M|             
      Adenoma                              |                                     X                                    |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                   X                    X                                 |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Skin                            |                                                                      X   |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Sarcoma Stromal                      |                                                                          |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Skin                            |                                                                      X   |             
      Endometrium, Polyp Stromal           |                         X                 X                    X         |             
      Endometrium, Polyp Stromal, Multiple |                                                    X                     |             
      Endometrium, Sarcoma Stromal         |                                                                          |             
                                            __________________________________________________________________________|             
   Vagina                                  |                            +                                             |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mediastinal, Leukemia Mononuclear    |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M|             
      Leukemia Mononuclear                 |                   X                 X                                    |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                   X                    X                                 |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                X  X           X     X  X     X                           |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Leukemia Mononuclear                 |                   X                 X                                    |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Skin                            |                                                                      X   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma                       | X                                                                        |             
      Fibroadenoma                         |                               X  X  X                             X      |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Squamous Cell Carcinoma              |                                                                      X   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  25                                                               
NTP Experiment-Test: 05041-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 10:44:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 1| 0| 0| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 5| 2| 7| 7| 6| 6| 2|             
                             DAY ON TEST   | 3| 7| 1| 0| 0| 3| 3| 3| 3| 0| 3| 3| 2| 2| 3| 3| 3| 7| 8| 8| 3| 3| 6| 0| 0|             
                                           | 2| 4| 1| 9| 5| 2| 2| 2| 2| 3| 2| 2| 6| 6| 2| 2| 2| 8| 6| 3| 2| 2| 3| 6| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    100MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
     HIGHFEM                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Subcutaneous Tissue, Fibroma         |                                                    X                     |             
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Astrocytoma Benign                   |                                                                   X      |             
      Ependymoma Benign                    |                                                                          |             
      Leukemia Mononuclear                 |                                        X                                 |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                X  X                 X  X     X                           |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Skin                            |                                                                      X   |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                     +                                    |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                   X                    X                                 |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Skin                            |                                                                      X   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                   X                 X  X                                 |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                X  X           X     X  X     X                           |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  26                                                               
NTP Experiment-Test: 05041-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 10:44:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 7| 7| 7| 6| 4| 0|                                            |            |
                             DAY ON TEST   | 3| 3| 2| 3| 3| 3| 3| 4| 1| 0|                                            |            |
                                           | 2| 2| 9| 2| 2| 2| 2| 2| 7| 5|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |     A      |
    100MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |     L      |
     HIGHFEM                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  A  +  +  +  +  +  +  +                                             |  55        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  A  +  +  +  +  +  +  +                                             |  53        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  A  +  +  +  +  +  +  +                                             |  55        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  A  +  +  +  +  +  +  +                                             |  53        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  A  +  +  +  +  +  +  +                                             |  52        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  A  +  +  +  +  +  +  +                                             |  52        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  A  +  +  +  +  +  +  +                                             |  51        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  A  +  +  +  +  +  +  +                                             |  51        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |                                                                          |          8 |
      Neoplastic Nodule                    |                X                                                         |          2 |
      Neoplastic Nodule, Multiple          |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Mesentery                               | +                                                                        |   3        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  A  +  +  +  +  +  +  +                                             |  59        |
      Leukemia Mononuclear                 |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +                                             |  58        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  A  +  +  +  +  +  +  +                                             |  57        |
      Leukemia Mononuclear                 |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  M  +  +  +  +  A  +  +                                             |  54        |
      Leukemia Mononuclear                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Leukemia Mononuclear                 |                                                                          |          4 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +                                             |  54        |
      Pheochromocytoma Benign              |          X  X     X                                                      |          3 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  M  +  M  +  +  +  +  +                                             |  44        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Pars Distalis, Adenoma               |                   X                                                      |         18 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  27                                                               
NTP Experiment-Test: 05041-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 10:44:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 7| 7| 7| 6| 4| 0|                                            |            |
                             DAY ON TEST   | 3| 3| 2| 3| 3| 3| 3| 4| 1| 0|                                            |            |
                                           | 2| 2| 9| 2| 2| 2| 2| 2| 7| 5|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |     A      |
    100MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |     L      |
     HIGHFEM                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Pars Distalis, Adenoma, Multiple     |                                                                          |          2 |
      Pars Distalis, Carcinoma             |                                                                          |          1 |
      Pars Distalis, Leukemia Mononuclear  |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      C-Cell, Adenoma                      |                X                                                         |          5 |
      C-Cell, Carcinoma                    |             X     X                                                      |          3 |
      Follicular Cell, Adenoma             |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +                                             |  53        |
      Adenoma                              |                X     X                                                   |          3 |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |                                                                          |          3 |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Skin                            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Sarcoma Stromal                      |    X                                                                     |          1 |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Skin                            |                                                                          |          1 |
      Endometrium, Polyp Stromal           | X                                                                        |          6 |
      Endometrium, Polyp Stromal, Multiple |                   X                                                      |          3 |
      Endometrium, Sarcoma Stromal         |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Vagina                                  |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Mediastinal, Leukemia Mononuclear    |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  M  +  +  +                                             |  55        |
      Leukemia Mononuclear                 |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Leukemia Mononuclear                 |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |                                                                          |          8 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +                                             |  52        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  28                                                               
NTP Experiment-Test: 05041-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 10:44:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 7| 7| 7| 6| 4| 0|                                            |            |
                             DAY ON TEST   | 3| 3| 2| 3| 3| 3| 3| 4| 1| 0|                                            |            |
                                           | 2| 2| 9| 2| 2| 2| 2| 2| 7| 5|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |     A      |
    100MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |     L      |
     HIGHFEM                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Leukemia Mononuclear                 |                                                                          |          2 |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Skin                            |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Adenocarcinoma                       |                                                                          |          2 |
      Fibroadenoma                         |             X     X                                                      |         12 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Squamous Cell Carcinoma              |                                                                          |          1 |
      Subcutaneous Tissue, Fibroma         |                                                                          |          1 |
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Astrocytoma Benign                   |                                                                          |          1 |
      Ependymoma Benign                    |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                         +                                                |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |                                                                          |          7 |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Skin                            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  57        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                +                                                         |   4        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |                                                                          |          3 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  29                                                               
NTP Experiment-Test: 05041-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 10:44:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 7| 7| 7| 6| 4| 0|                                            |            |
                             DAY ON TEST   | 3| 3| 2| 3| 3| 3| 3| 4| 1| 0|                                            |            |
                                           | 2| 2| 9| 2| 2| 2| 2| 2| 7| 5|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |     A      |
    100MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |     L      |
     HIGHFEM                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Skin                            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |                                                                          |          3 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |                                                                          |          8 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  30                                                               
NTP Experiment-Test: 05041-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 10:44:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 2| 1| 4| 2| 2| 2| 2| 7| 2| 2| 2| 4| 8| 2| 2| 2| 2| 2| 2| 2| 0| 2| 2|             
                                           | 9| 9| 9| 1| 9| 9| 9| 9| 9| 5| 9| 9| 9| 6| 1| 9| 9| 9| 9| 9| 9| 9| 6| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leiomyosarcoma                       |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A  +  +|             
      Leukemia Mononuclear                 |                            X                                             |             
      Lipoma                               |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | M  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A  +  +|             
      Leiomyosarcoma                       |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X              X                    X        X  X        X  X|             
      Neoplastic Nodule                    |                                                             X            |             
                                            __________________________________________________________________________|             
   Mesentery                               |             +           +  +     +                          +           +|             
      Leukemia Mononuclear                 |                            X                                             |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                            X                                             |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Sarcoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  A  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X              X                                             |             
      Osteosarcoma, Metastatic, Bone       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma                            |                                                 X                        |             
      Leukemia Mononuclear                 |                                                 X                    X   |             
      Osteosarcoma, Metastatic, Bone       |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Pheochromocytoma Malignant           |       X                 X                    X                           |             
      Pheochromocytoma Benign              |          X        X           X     X              X        X     X      |             
      Pheochromocytoma Benign, Multiple    | X                                                              X         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  31                                                               
NTP Experiment-Test: 05041-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 10:44:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 2| 1| 4| 2| 2| 2| 2| 7| 2| 2| 2| 4| 8| 2| 2| 2| 2| 2| 2| 2| 0| 2| 2|             
                                           | 9| 9| 9| 1| 9| 9| 9| 9| 9| 5| 9| 9| 9| 6| 1| 9| 9| 9| 9| 9| 9| 9| 6| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Bilateral, Pheochromocytoma Malignant|                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma, Multiple                    |                                                                          |             
      Carcinoma                            |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  M  +  +  +  M  +  +|             
      Adenoma                              |                               X                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  M  +  +|             
      Pars Distalis, Adenoma               | X  X  X              X                 X        X        X              X|             
      Pars Distalis, Adenoma, Multiple     |                                                                          |             
      Pars Distalis, Leukemia Mononuclear  |                                                                          |             
      Pars Intermedia, Adenoma             |    X                                                                     |             
      Pars Intermedia, Leukemia Mononuclear|             X                                                            |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      C-Cell, Adenoma                      |                                  X           X                 X     X   |             
      C-Cell, Carcinoma                    | X                                                     X           X      |             
      Follicular Cell, Adenoma             |                               X                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                   +      |             
      Schwannoma Malignant, Metastatic,    |                                                                          |             
           Spinal Cord                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mesothelioma Malignant               |                                                 X                        |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  M  +  +  +  +  +  +  M  M  +  +  M  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Mesothelioma Malignant               |                                                 X                        |             
      Interstitial Cell, Adenoma           |             X                             X                              |             
      Interstitial Cell, Adenoma, Multiple | X  X  X  X     X  X  X  X  X  X  X  X        X  X  X  X  X  X  X  X  X  X|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  M  +  +  M  M  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Leukemia Mononuclear                 |                            X                                             |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  32                                                               
NTP Experiment-Test: 05041-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 10:44:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 2| 1| 4| 2| 2| 2| 2| 7| 2| 2| 2| 4| 8| 2| 2| 2| 2| 2| 2| 2| 0| 2| 2|             
                                           | 9| 9| 9| 1| 9| 9| 9| 9| 9| 5| 9| 9| 9| 6| 1| 9| 9| 9| 9| 9| 9| 9| 6| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hemangiosarcoma                      |                                                                          |             
      Leukemia Mononuclear                 |             X              X                    X        X  X        X  X|             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  M  +  +  +  M  M  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  M|             
      Leukemia Mononuclear                 |                            X                                             |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +  M  +  +  M|             
      Adenoma                              |                                                                          |             
      Fibroadenoma                         |          X                                                               |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basal Cell Carcinoma                 |                                                          X               |             
      Keratoacanthoma                      |          X                                                               |             
      Squamous Cell Papilloma              |                                                                         X|             
      Trichoepithelioma                    |                                                                          |             
      Subcutaneous Tissue, Fibroma         |                                     X                                    |             
      Subcutaneous Tissue, Myxosarcoma     |                   X                                                      |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femur, Osteosarcoma                  |                                                                          |             
      Vertebra, Osteosarcoma               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Glioma Benign                        |                                           X                              |             
      Leukemia Mononuclear                 |                                                                          |             
      Cerebrum, Glioma Benign              |                                                                   X      |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
      Schwannoma Malignant                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                     X                                    |             
      Leukemia Mononuclear                 |             X              X                    X        X           X   |             
      Osteosarcoma, Metastatic, Bone       |                                                                          |             
      Sarcoma, Metastatic, Salivary Glands |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     | +     +                       +                                      +   |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                      +   |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  33                                                               
NTP Experiment-Test: 05041-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 10:44:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 2| 1| 4| 2| 2| 2| 2| 7| 2| 2| 2| 4| 8| 2| 2| 2| 2| 2| 2| 2| 0| 2| 2|             
                                           | 9| 9| 9| 1| 9| 9| 9| 9| 9| 5| 9| 9| 9| 6| 1| 9| 9| 9| 9| 9| 9| 9| 6| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                            X                                             |             
      Osteosarcoma, Metastatic, Bone       |                                                                          |             
      Renal Tubule, Adenoma                |                                                                          |             
                                            __________________________________________________________________________|             
   Ureter                                  |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X              X                    X        X  X        X  X|             
      Mesothelioma Malignant               |                                                 X                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  34                                                               
NTP Experiment-Test: 05041-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 10:44:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 6| 7| 7| 6| 6| 5| 7| 7| 7| 3| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5|             
                             DAY ON TEST   | 2| 2| 9| 8| 4| 2| 2| 3| 3| 9| 2| 1| 0| 6| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 9|             
                                           | 9| 9| 1| 1| 2| 9| 9| 2| 2| 0| 9| 5| 8| 4| 2| 9| 3| 9| 9| 9| 9| 9| 9| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    CONTROL                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leiomyosarcoma                       |             X                                                            |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  M  +  +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Lipoma                               |                                                       X                  |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  M  +  +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  M  +  +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Leiomyosarcoma                       |                                     X                                    |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  M  +  +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X     X              X     X                                             |             
      Neoplastic Nodule                    |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               | +                 +                 +           +              +         |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                      X                                                   |             
      Sarcoma                              |       X                                                                  |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                            X                                             |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                      X     X                                             |             
      Osteosarcoma, Metastatic, Bone       |                                                                X         |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma                            |                                                                          |             
      Leukemia Mononuclear                 |                            X                                             |             
      Osteosarcoma, Metastatic, Bone       |                                                                X         |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                      X                                                   |             
      Pheochromocytoma Malignant           |                                                       X                  |             
      Pheochromocytoma Benign              | X              X     X  X  X                       X                     |             
      Pheochromocytoma Benign, Multiple    |                                                 X                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  35                                                               
NTP Experiment-Test: 05041-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 10:44:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 6| 7| 7| 6| 6| 5| 7| 7| 7| 3| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5|             
                             DAY ON TEST   | 2| 2| 9| 8| 4| 2| 2| 3| 3| 9| 2| 1| 0| 6| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 9|             
                                           | 9| 9| 1| 1| 2| 9| 9| 2| 2| 0| 9| 5| 8| 4| 2| 9| 3| 9| 9| 9| 9| 9| 9| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    CONTROL                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Bilateral, Pheochromocytoma Malignant|                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma, Multiple                    |                                                                X         |             
      Carcinoma                            |          X                                                               |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  M  M  +  M  +  +  +  M  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               |                         X        X  X        X        X  X  X        X  X|             
      Pars Distalis, Adenoma, Multiple     |                                                                          |             
      Pars Distalis, Leukemia Mononuclear  |                            X                                             |             
      Pars Intermedia, Adenoma             |                                                                          |             
      Pars Intermedia, Leukemia Mononuclear|                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                            X                                             |             
      C-Cell, Adenoma                      |                                              X     X     X               |             
      C-Cell, Carcinoma                    | X                                                                        |             
      Follicular Cell, Adenoma             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                        +                                 |             
      Schwannoma Malignant, Metastatic,    |                                                                          |             
           Spinal Cord                     |                                        X                                 |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mesothelioma Malignant               |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  M  +  +  +  +  M  +  +  M  +  +  +  +  +  +  M  +  +  +|             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                            X                                             |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Mesothelioma Malignant               |                                                                          |             
      Interstitial Cell, Adenoma           |                            X     X  X  X                                X|             
      Interstitial Cell, Adenoma, Multiple | X  X  X  X  X  X  X  X        X           X  X  X  X  X  X  X  X  X  X   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                            X                                             |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                            X                                             |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  36                                                               
NTP Experiment-Test: 05041-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 10:44:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 6| 7| 7| 6| 6| 5| 7| 7| 7| 3| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5|             
                             DAY ON TEST   | 2| 2| 9| 8| 4| 2| 2| 3| 3| 9| 2| 1| 0| 6| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 9|             
                                           | 9| 9| 1| 1| 2| 9| 9| 2| 2| 0| 9| 5| 8| 4| 2| 9| 3| 9| 9| 9| 9| 9| 9| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    CONTROL                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hemangiosarcoma                      |                                                                          |             
      Leukemia Mononuclear                 | X     X              X     X                                             |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  M  +  +  M  M  +  +  +  +  +  +  +  +  +  M  +  M  M  +  +  +  M  +|             
      Leukemia Mononuclear                 |                      X     X                                             |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +|             
      Adenoma                              |                                                             X            |             
      Fibroadenoma                         |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basal Cell Carcinoma                 |                                                                          |             
      Keratoacanthoma                      |       X                                                                  |             
      Squamous Cell Papilloma              |                                                                          |             
      Trichoepithelioma                    |                                                 X     X                  |             
      Subcutaneous Tissue, Fibroma         |                                           X                              |             
      Subcutaneous Tissue, Myxosarcoma     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femur, Osteosarcoma                  |                                                                X         |             
      Vertebra, Osteosarcoma               |                                                                X         |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Glioma Benign                        |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
      Cerebrum, Glioma Benign              |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |          +              +              +                                 |             
      Schwannoma Malignant                 |                                        X                                 |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |    X                                                                     |             
      Leukemia Mononuclear                 | X     X              X                                                   |             
      Osteosarcoma, Metastatic, Bone       |                                                                X         |             
      Sarcoma, Metastatic, Salivary Glands |       X                                                                  |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     | +        +                                      +                 +      |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                   +      |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  37                                                               
NTP Experiment-Test: 05041-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 10:44:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 6| 7| 7| 6| 6| 5| 7| 7| 7| 3| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5|             
                             DAY ON TEST   | 2| 2| 9| 8| 4| 2| 2| 3| 3| 9| 2| 1| 0| 6| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 9|             
                                           | 9| 9| 1| 1| 2| 9| 9| 2| 2| 0| 9| 5| 8| 4| 2| 9| 3| 9| 9| 9| 9| 9| 9| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    CONTROL                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                            X                                             |             
      Osteosarcoma, Metastatic, Bone       |                                                                X         |             
      Renal Tubule, Adenoma                |                                                                          |             
                                            __________________________________________________________________________|             
   Ureter                                  |                                        +                                 |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                      X                                                   |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X     X              X     X                                             |             
      Mesothelioma Malignant               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  38                                                               
NTP Experiment-Test: 05041-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 10:44:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 6| 6| 7| 7| 6| 1| 7|                                            |            |
                             DAY ON TEST   | 2| 2| 9| 9| 0| 2| 1| 6| 4| 2|                                            |            |
                                           | 9| 9| 6| 1| 3| 9| 6| 1| 5| 9|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |     A      |
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |     L      |
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leiomyosarcoma                       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  A  +  A  +  +  +                                             |  54        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  A  +  A  +  M  +                                             |  52        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Lipoma                               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  A  +  A  +  +  +                                             |  54        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  A  +  A  +  M  +                                             |  51        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  A  +  A  +  +  +                                             |  54        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  A  +  A  +  A  +                                             |  52        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  A  +  A  +  M  +                                             |  53        |
      Leiomyosarcoma                       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  A  +  A  +  M  +                                             |  52        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |       X  X                                                               |         13 |
      Neoplastic Nodule                    |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Mesentery                               | +              +                                                         |  13        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Sarcoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  58        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |       X                                                                  |          5 |
      Osteosarcoma, Metastatic, Bone       |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Carcinoma                            |                                                                          |          1 |
      Leukemia Mononuclear                 |       X  X                                                               |          5 |
      Osteosarcoma, Metastatic, Bone       |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  39                                                               
NTP Experiment-Test: 05041-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 10:44:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 6| 6| 7| 7| 6| 1| 7|                                            |            |
                             DAY ON TEST   | 2| 2| 9| 9| 0| 2| 1| 6| 4| 2|                                            |            |
                                           | 9| 9| 6| 1| 3| 9| 6| 1| 5| 9|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |     A      |
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |     L      |
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  M  +                                             |  58        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Pheochromocytoma Malignant           |                                                                          |          4 |
      Pheochromocytoma Benign              |                      X                                                   |         14 |
      Pheochromocytoma Benign, Multiple    |                                                                          |          3 |
      Bilateral, Pheochromocytoma Malignant|                   X                                                      |          1 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Adenoma, Multiple                    |                                                                          |          1 |
      Carcinoma                            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  M  +  +  +  +  +  +  +  +                                             |  51        |
      Adenoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  57        |
      Pars Distalis, Adenoma               |                X     X                                                   |         19 |
      Pars Distalis, Adenoma, Multiple     |    X                                                                     |          1 |
      Pars Distalis, Leukemia Mononuclear  |                                                                          |          1 |
      Pars Intermedia, Adenoma             |                                                                          |          1 |
      Pars Intermedia, Leukemia Mononuclear|                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      C-Cell, Adenoma                      |                                                                          |          7 |
      C-Cell, Carcinoma                    |    X              X                                                      |          6 |
      Follicular Cell, Adenoma             |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   2        |
      Schwannoma Malignant, Metastatic,    |                                                                          |            |
           Spinal Cord                     |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Mesothelioma Malignant               |             X                                                            |          2 |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  M  +  +  +  M  M  M  +                                             |  48        |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  M  +                                             |  59        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |       X                                                                  |          1 |
      Mesothelioma Malignant               |             X                                                            |          2 |
      Interstitial Cell, Adenoma           |             X                                                            |          8 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  40                                                               
NTP Experiment-Test: 05041-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 10:44:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 6| 6| 7| 7| 6| 1| 7|                                            |            |
                             DAY ON TEST   | 2| 2| 9| 9| 0| 2| 1| 6| 4| 2|                                            |            |
                                           | 9| 9| 6| 1| 3| 9| 6| 1| 5| 9|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |     A      |
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |     L      |
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Interstitial Cell, Adenoma, Multiple | X  X  X  X     X  X        X                                             |         48 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  M  M                                             |  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  M  +  +  +                                             |  57        |
      Leukemia Mononuclear                 |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Hemangiosarcoma                      |                         X                                                |          1 |
      Leukemia Mononuclear                 |       X  X                                                               |         13 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  M  M  +  +  +                                             |  45        |
      Leukemia Mononuclear                 |                                                                          |          3 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  M  +  +  +  +  +  M  M                                             |  48        |
      Adenoma                              |                                                                          |          1 |
      Fibroadenoma                         |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Basal Cell Carcinoma                 |                                                                          |          1 |
      Keratoacanthoma                      |                                                                          |          2 |
      Squamous Cell Papilloma              |                X                                                         |          2 |
      Trichoepithelioma                    |                                                                          |          2 |
      Subcutaneous Tissue, Fibroma         |          X                                                               |          3 |
      Subcutaneous Tissue, Myxosarcoma     |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Femur, Osteosarcoma                  |                                                                          |          1 |
      Vertebra, Osteosarcoma               |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Glioma Benign                        |                                                                          |          1 |
      Leukemia Mononuclear                 |       X                                                                  |          1 |
      Cerebrum, Glioma Benign              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   3        |
      Schwannoma Malignant                 |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  41                                                               
NTP Experiment-Test: 05041-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 10:44:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 6| 6| 7| 7| 6| 1| 7|                                            |            |
                             DAY ON TEST   | 2| 2| 9| 9| 0| 2| 1| 6| 4| 2|                                            |            |
                                           | 9| 9| 6| 1| 3| 9| 6| 1| 5| 9|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |     A      |
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |     L      |
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Alveolar/Bronchiolar Adenoma         |                                                                          |          2 |
      Leukemia Mononuclear                 |       X                                                                  |          9 |
      Osteosarcoma, Metastatic, Bone       |                                                                          |          1 |
      Sarcoma, Metastatic, Salivary Glands |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  M  +                                             |  58        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   8        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |                                                                          |          2 |
      Osteosarcoma, Metastatic, Bone       |                                                                          |          1 |
      Renal Tubule, Adenoma                |                      X                                                   |          1 |
                                            __________________________________________________________________________|____________|
   Ureter                                  |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Leukemia Mononuclear                 |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |       X  X                                                               |         13 |
      Mesothelioma Malignant               |             X                                                            |          2 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  42                                                               
NTP Experiment-Test: 05041-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 10:44:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 6| 3| 7| 6| 6| 1| 2| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 7| 7| 7| 7| 0|             
                             DAY ON TEST   | 3| 9| 3| 2| 6| 0| 7| 4| 9| 7| 3| 3| 3| 3| 3| 3| 3| 0| 8| 7| 3| 3| 1| 3| 0|             
                                           | 0| 0| 4| 0| 5| 5| 7| 1| 1| 9| 0| 0| 0| 0| 0| 0| 0| 3| 3| 5| 0| 0| 6| 0| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    50MG/KG                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    LOW MALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +  +  +  +  +  +  +  +  +                       +  +  +        +     +|             
                                            __________________________________________________________________________|             
   Intestine Large                         |    +  A  +  +  +  +  +  A  +                       +  +  +        +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    +  A  M  +  +  +  +  A  +                       +  +  +        +     M|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +  A  +  +  +  +  +  A  +                       +  +  +        +     A|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +  A  +  +  +  +  +  A  +                       +  +  +        +     M|             
                                            __________________________________________________________________________|             
   Intestine Small                         |    +  A  +  +  +  +  +  A  +                       +  +  +        +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +  A  +  +  +  +  +  A  +                       +  +  +        +     A|             
      Leiomyosarcoma                       |                                                          X               |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    +  A  +  +  +  +  +  A  +                       +  +  +        +     M|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +  A  +  +  +  +  +  A  +                       +  +  +        +     M|             
                                            __________________________________________________________________________|             
   Liver                                   |    +  +  +  +  +  +  +  +  +     +  +  +     +     +  +  +     +  +  +  +|             
      Leukemia Mononuclear                 |    X                 X                                                   |             
      Schwannoma Malignant, Metastatic,    |                                                                          |             
           Peripheral Nerve                |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                   +                    +                    +  +         |             
      Fibrosarcoma                         |                                                                          |             
      Mesothelioma Malignant               |                   X                                                      |             
      Sarcoma                              |                                        X                                 |             
      Schwannoma Malignant, Metastatic,    |                                                                          |             
           Peripheral Nerve                |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +  +  +  +  +  +  +  +  +                       +  +  +        +     A|             
      Mesothelioma Malignant               |                   X                                                      |             
      Schwannoma Malignant, Metastatic,    |                                                                          |             
           Peripheral Nerve                |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +  +  +  +  +  +  +  +  +                       +  +  +        +      |             
      Adenocarcinoma                       |             X                                                            |             
      Sarcoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 |    +  +  +  +  +  +  +  +  +                       +  +  +        +     +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +  +  +  +  +  +  +  +  +                       +  +  +        +     +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +  +  +  +  +  +  +  +  +                       +  +  +        +     +|             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                       +                  |             
      Neoplasm NOS                         |                                                       X                  |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |    +  +  +  +  +  +  +  +  +        +              +  +  +        +     +|             
      Adenocarcinoma, Metastatic, Salivary |                                                                          |             
          Glands                           |             X                                                            |             
      Leukemia Mononuclear                 |                                                                          |             
      Endocardium, Schwannoma Malignant    |                                                    X                     |             
      Epicardium, Alveolar/Bronchiolar     |                                                                          |             
          Carcinoma, Metastatic, Lung      |                X                                                         |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  43                                                               
NTP Experiment-Test: 05041-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 10:44:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 6| 3| 7| 6| 6| 1| 2| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 7| 7| 7| 7| 0|             
                             DAY ON TEST   | 3| 9| 3| 2| 6| 0| 7| 4| 9| 7| 3| 3| 3| 3| 3| 3| 3| 0| 8| 7| 3| 3| 1| 3| 0|             
                                           | 0| 0| 4| 0| 5| 5| 7| 1| 1| 9| 0| 0| 0| 0| 0| 0| 0| 3| 3| 5| 0| 0| 6| 0| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    50MG/KG                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    LOW MALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X                    X                                                   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X                    X                                                   |             
      Neuroblastoma Malignant              |                                                                          |             
      Pheochromocytoma Malignant           |                                                             X            |             
      Pheochromocytoma Benign              |                X                    X              X              X      |             
      Pheochromocytoma Benign, Multiple    |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +  +  +  +  +  +  +  +  +              +        +  +  +        +     A|             
      Adenoma                              |                                           X                              |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    +  +  +  +  +  +  +  +  M                       +  +  +        +     +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               |                                           X  X  X                        |             
      Pars Distalis, Adenoma, Multiple     |                                                                          |             
      Pars Distalis, Leukemia Mononuclear  |                                                                          |             
      Pars Intermedia, Adenoma             |                X                                                         |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Adenoma                      |       X  X                                                           X   |             
      C-Cell, Carcinoma                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |    +  +  +  +  +  +  +  +  +                       +  +  +        +     +|             
      Mesothelioma Malignant               |       X           X                                                      |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |    +  +  +  +  +  M  +  +  +                    +  M  +  M        M  +  M|             
      Adenoma                              |                                                                      X   |             
                                            __________________________________________________________________________|             
   Prostate                                |    +  +  +  +  +  +  +  +  +                       +  +  +        +     +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |    +  +  +  +  +  +  +  +  +                       +  +  +        +     +|             
      Mesothelioma Malignant               |                   X                                                      |             
      Schwannoma Malignant, Metastatic,    |                                                                          |             
           Peripheral Nerve                |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Mesothelioma Malignant               |       X           X                             X                        |             
      Interstitial Cell, Adenoma           |    X  X                                      X                           |             
      Interstitial Cell, Adenoma, Multiple | X        X     X  X  X        X  X  X  X        X  X  X  X  X  X  X  X   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +  +  +  +  +  +  +  +  +                       +  +  +        +     +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +  +  +  +  +  +  +  +  +                       +  +  +        +     +|             
      Mediastinal, Leukemia Mononuclear    |    X                                                                     |             
      Mediastinal, Mesothelioma Malignant, |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  44                                                               
NTP Experiment-Test: 05041-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 10:44:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 6| 3| 7| 6| 6| 1| 2| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 7| 7| 7| 7| 0|             
                             DAY ON TEST   | 3| 9| 3| 2| 6| 0| 7| 4| 9| 7| 3| 3| 3| 3| 3| 3| 3| 0| 8| 7| 3| 3| 1| 3| 0|             
                                           | 0| 0| 4| 0| 5| 5| 7| 1| 1| 9| 0| 0| 0| 0| 0| 0| 0| 3| 3| 5| 0| 0| 6| 0| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    50MG/KG                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    LOW MALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
           Metastatic, Mesentery           |                   X                                                      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |    +  +  +  M  +  +  +  +  +                       +  +  +        +     +|             
      Leukemia Mononuclear                 |    X                 X                                                   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |    +  +  +  +  +  +  +  +  +                       +  +  +        +     A|             
      Leukemia Mononuclear                 |                      X                                                   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +     +                 +  +  +        +  +  +|             
      Leukemia Mononuclear                 | X  X                 X                                                   |             
      Mesothelioma Malignant               |       X           X                                                      |             
      Schwannoma Malignant, Metastatic,    |                                                                          |             
           Peripheral Nerve                |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  |    +  +  +  M  +  +  +  +  +                       +  +  +        +     +|             
      Leukemia Mononuclear                 |                                                                          |             
      Schwannoma Malignant                 |                                                                          |             
      Schwannoma Malignant, Metastatic,    |                                                                          |             
           Peripheral Nerve                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    +  +  +  +  +  +  +  M  +                       M  +  +        +  +  +|             
      Fibroadenoma                         |                                                                      X   |             
                                            __________________________________________________________________________|             
   Skin                                    |    +  +  +  +  +  +  +  +  +                       +  M  +        +     +|             
      Squamous Cell Papilloma              |                                                                          |             
      Subcutaneous Tissue, Fibroma         |                                                                   X      |             
      Subcutaneous Tissue, Neurofibroma    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +  +  +  +  +  +  +  +  +                       +  +  +        +     +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                +                                                         |             
      Diaphragm, Alveolar/Bronchiolar      |                                                                          |             
          Carcinoma, Metastatic, Lung      |                X                                                         |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +  +  +  +  +  +  +  +  +                       +  +  +        +     +|             
      Oligodendroglioma Benign             |                                                                          |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
      Schwannoma Malignant                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  |    +  +  +  +  +  +  +  +  +                       +  +  +              +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma, Metastatic, Salivary |                                                                          |             
          Glands                           |             X                                                            |             
      Alveolar/Bronchiolar Carcinoma       |                X                                                         |             
      Leukemia Mononuclear                 | X  X                 X                                                   |             
      Mesothelioma Malignant, Metastatic,  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  45                                                               
NTP Experiment-Test: 05041-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 10:44:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 6| 3| 7| 6| 6| 1| 2| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 7| 7| 7| 7| 0|             
                             DAY ON TEST   | 3| 9| 3| 2| 6| 0| 7| 4| 9| 7| 3| 3| 3| 3| 3| 3| 3| 0| 8| 7| 3| 3| 1| 3| 0|             
                                           | 0| 0| 4| 0| 5| 5| 7| 1| 1| 9| 0| 0| 0| 0| 0| 0| 0| 3| 3| 5| 0| 0| 6| 0| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    50MG/KG                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    LOW MALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
           Mesentery                       |                   X                                                      |             
      Schwannoma Malignant, Metastatic,    |                                                                          |             
           Peripheral Nerve                |                                                                          |             
      Pleura, Mediastinum,                 |                                                                          |             
          Alveolar/Bronchiolar Carcinoma,  |                                                                          |             
           Metastatic, Lung                |                X                                                         |             
      Pleura, Mediastinum, Thymoma         |                                                                          |             
          Malignant, Metastatic, Thymus    |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Trachea                                 |    +  +  +  +  +  +  +  +  +                       +  +  +        +     +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |    +           +                          +        +                     |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                    +                     |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
      Adenoma                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                      X                                                   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    +  +  +  +  +  +  +  +  +                       +     +        +     +|             
      Mesothelioma Malignant               |       X                                                                  |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X  X                 X                                                   |             
      Mesothelioma Malignant               |       X           X                             X                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  46                                                               
NTP Experiment-Test: 05041-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 10:44:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 7| 7| 6| 5| 5| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 4|             
                             DAY ON TEST   | 3| 1| 7| 2| 3| 3| 4| 6| 5| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 3| 3| 3| 1| 9|             
                                           | 0| 6| 6| 0| 0| 0| 1| 8| 0| 0| 0| 0| 0| 0| 2| 0| 0| 0| 0| 0| 0| 0| 0| 9| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    50MG/KG                                | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    LOW MALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +  +  +        +  +  +                 +                    +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         |    +  +  +        +  +  +                 +                    +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    +  +  +        +  +  +                 A                    +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +  +  +        +  +  +                 +                    +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +  +  +        +  +  +                 +                    +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         |    +  +  +        +  +  +                 +                    +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +  +  +        +  +  +                 +                    +     +  +|             
      Leiomyosarcoma                       |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    +  +  +        +  +  +                 +                    +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +  +  +        +  +  +                 +                    +     +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +     +  +     +  +|             
      Leukemia Mononuclear                 |       X     X  X                                   X                     |             
      Schwannoma Malignant, Metastatic,    |                                                                          |             
           Peripheral Nerve                |                         X                                                |             
                                            __________________________________________________________________________|             
   Mesentery                               |             +           +           +     +        +  +           +      |             
      Fibrosarcoma                         |                                           X                              |             
      Mesothelioma Malignant               |                                                                          |             
      Sarcoma                              |                                                                          |             
      Schwannoma Malignant, Metastatic,    |                                                                          |             
           Peripheral Nerve                |                         X                                                |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +  +           +  +  +                 +                    +     +  +|             
      Mesothelioma Malignant               |                                                                          |             
      Schwannoma Malignant, Metastatic,    |                                                                          |             
           Peripheral Nerve                |                         X                                                |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +  +  +        +  +  +                 +                    +     +  +|             
      Adenocarcinoma                       |                                                                          |             
      Sarcoma                              |                                                                      X   |             
                                            __________________________________________________________________________|             
   Stomach                                 |    +  +           +  +  +                 +  +        +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +  +           +  +  +                 +           +  +     +     +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +  +           +  +  +                 +  +        +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Neoplasm NOS                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |    +  +  +        +  +  +                 +                    +     +  +|             
      Adenocarcinoma, Metastatic, Salivary |                                                                          |             
          Glands                           |                                                                          |             
      Leukemia Mononuclear                 |       X                                                                  |             
      Endocardium, Schwannoma Malignant    |                                                                          |             
      Epicardium, Alveolar/Bronchiolar     |                                                                          |             
          Carcinoma, Metastatic, Lung      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  47                                                               
NTP Experiment-Test: 05041-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 10:44:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 7| 7| 6| 5| 5| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 4|             
                             DAY ON TEST   | 3| 1| 7| 2| 3| 3| 4| 6| 5| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 3| 3| 3| 1| 9|             
                                           | 0| 6| 6| 0| 0| 0| 1| 8| 0| 0| 0| 0| 0| 0| 2| 0| 0| 0| 0| 0| 0| 0| 0| 9| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    50MG/KG                                | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    LOW MALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X     X  X                                                         |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X                                            X                     |             
      Neuroblastoma Malignant              |                               X                                          |             
      Pheochromocytoma Malignant           |          X                                X                              |             
      Pheochromocytoma Benign              |                   X                                            X         |             
      Pheochromocytoma Benign, Multiple    |    X                                                                     |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +  +           +  +  +                 +                    +     +  +|             
      Adenoma                              |       X                                                                  |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    +  +  +        +  +  +                 +                    +     +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               |    X  X        X     X        X  X                       X     X  X     X|             
      Pars Distalis, Adenoma, Multiple     |                         X                                                |             
      Pars Distalis, Leukemia Mononuclear  |       X                                                                  |             
      Pars Intermedia, Adenoma             |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Adenoma                      | X     X                    X                                             |             
      C-Cell, Carcinoma                    |                                                                   X      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |    +  +  +        +  +  +                 +  +                 +     +  +|             
      Mesothelioma Malignant               |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |    +  +  +        +  +  +     +           M                    +     +  M|             
      Adenoma                              |    X              X           X                                          |             
                                            __________________________________________________________________________|             
   Prostate                                |    +  +  +        +  +  +                 +     +              +     +  +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +        +     +                 +              +  +  +     +  +|             
      Mesothelioma Malignant               |                                                                          |             
      Schwannoma Malignant, Metastatic,    |                                                                          |             
           Peripheral Nerve                |                         X                                                |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Mesothelioma Malignant               |                                                                          |             
      Interstitial Cell, Adenoma           |       X                                                                  |             
      Interstitial Cell, Adenoma, Multiple | X  X     X  X  X  X        X     X  X  X  X  X  X  X  X     X  X  X  X   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +  +  +        +  +  +                 +                    +     +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +  +  +        +  +  +                 +                    +     +  +|             
      Mediastinal, Leukemia Mononuclear    |                                                                          |             
      Mediastinal, Mesothelioma Malignant, |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  48                                                               
NTP Experiment-Test: 05041-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 10:44:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 7| 7| 6| 5| 5| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 4|             
                             DAY ON TEST   | 3| 1| 7| 2| 3| 3| 4| 6| 5| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 3| 3| 3| 1| 9|             
                                           | 0| 6| 6| 0| 0| 0| 1| 8| 0| 0| 0| 0| 0| 0| 2| 0| 0| 0| 0| 0| 0| 0| 0| 9| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    50MG/KG                                | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    LOW MALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
           Metastatic, Mesentery           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |    +  +  +        +  +  +                 +                    +     +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |    +  +  +        +  +  +                 +                    +     +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  |    +  +  +  +  +  +  +  +  +           +  +        +           +     +  +|             
      Leukemia Mononuclear                 |       X     X  X                                   X                     |             
      Mesothelioma Malignant               |                                                                          |             
      Schwannoma Malignant, Metastatic,    |                                                                          |             
           Peripheral Nerve                |                         X                                                |             
                                            __________________________________________________________________________|             
   Thymus                                  |    +  +  +        +  +  +                 +                    +     +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Schwannoma Malignant                 |                                                                          |             
      Schwannoma Malignant, Metastatic,    |                                                                          |             
           Peripheral Nerve                |                         X                                                |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    +  +  +        M  M  +                 +                 +  M     +  +|             
      Fibroadenoma                         |                                                             X            |             
                                            __________________________________________________________________________|             
   Skin                                    |    +  +  +        +  +  +  +              +                    +     +  +|             
      Squamous Cell Papilloma              |                            X                                             |             
      Subcutaneous Tissue, Fibroma         |                                                                          |             
      Subcutaneous Tissue, Neurofibroma    |                                                                         X|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +  +  +        +  +  +                 +                    +     +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Diaphragm, Alveolar/Bronchiolar      |                                                                          |             
          Carcinoma, Metastatic, Lung      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |       +  +        +  +  +                 +                    +     +  +|             
      Oligodendroglioma Benign             |                                                                          |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                         +                                                |             
      Schwannoma Malignant                 |                         X                                                |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  |    +  +  +        +  +  +                 +                    +     +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma, Metastatic, Salivary |                                                                          |             
          Glands                           |                                                                          |             
      Alveolar/Bronchiolar Carcinoma       |                                                                          |             
      Leukemia Mononuclear                 |       X     X  X                                                         |             
      Mesothelioma Malignant, Metastatic,  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  49                                                               
NTP Experiment-Test: 05041-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 10:44:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 7| 7| 6| 5| 5| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 4|             
                             DAY ON TEST   | 3| 1| 7| 2| 3| 3| 4| 6| 5| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 3| 3| 3| 1| 9|             
                                           | 0| 6| 6| 0| 0| 0| 1| 8| 0| 0| 0| 0| 0| 0| 2| 0| 0| 0| 0| 0| 0| 0| 0| 9| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    50MG/KG                                | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    LOW MALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
           Mesentery                       |                                                                          |             
      Schwannoma Malignant, Metastatic,    |                                                                          |             
           Peripheral Nerve                |                         X                                                |             
      Pleura, Mediastinum,                 |                                                                          |             
          Alveolar/Bronchiolar Carcinoma,  |                                                                          |             
           Metastatic, Lung                |                                                                          |             
      Pleura, Mediastinum, Thymoma         |                                                                          |             
          Malignant, Metastatic, Thymus    |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 |    +  +  +        +  +  +                 +                    +     +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                         +                    +  +  +                     |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                   +                                                      |             
      Adenoma                              |                   X                                                      |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                X                                                         |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    +  +  +        +  +  +                 +                    +     +  +|             
      Mesothelioma Malignant               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X     X  X                                   X                     |             
      Mesothelioma Malignant               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  50                                                               
NTP Experiment-Test: 05041-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 10:44:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 4| 7| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 2| 3| 9| 5| 3| 3| 3| 3| 3| 1|                                            |            |
                                           | 3| 0| 8| 1| 0| 1| 1| 1| 1| 4|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |     A      |
    50MG/KG                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |     L      |
    LOW MALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +     +  +                 +                                             |  28        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +     +  +        +        +                                             |  27        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +     +  +        +        +                                             |  24        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +     +  +                 +                                             |  25        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +     +  +                 +                                             |  25        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +     +  +                 A                                             |  25        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +     +  +                 A                                             |  24        |
      Leiomyosarcoma                       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +     +  +                 A                                             |  24        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +     A  +                 A                                             |  23        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +     +  +     +     +     +                                             |  47        |
      Leukemia Mononuclear                 | X              X     X     X                                             |         10 |
      Schwannoma Malignant, Metastatic,    |                                                                          |            |
           Peripheral Nerve                |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |    +     +                 +                                             |  14        |
      Fibrosarcoma                         |                                                                          |          1 |
      Mesothelioma Malignant               |                                                                          |          1 |
      Sarcoma                              |                                                                          |          1 |
      Schwannoma Malignant, Metastatic,    |                                                                          |            |
           Peripheral Nerve                |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +     +  +                 +                                             |  26        |
      Mesothelioma Malignant               |                                                                          |          1 |
      Schwannoma Malignant, Metastatic,    |                                                                          |            |
           Peripheral Nerve                |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +     +  +                 +                                             |  27        |
      Adenocarcinoma                       |                                                                          |          1 |
      Sarcoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +     +  +                 +                                             |  31        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +     +  +                 +                                             |  29        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +     +  +                 +                                             |  31        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
      Neoplasm NOS                         |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +     +  +                 +                                             |  29        |
      Adenocarcinoma, Metastatic, Salivary |                                                                          |            |
          Glands                           |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Endocardium, Schwannoma Malignant    |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  51                                                               
NTP Experiment-Test: 05041-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 10:44:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 4| 7| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 2| 3| 9| 5| 3| 3| 3| 3| 3| 1|                                            |            |
                                           | 3| 0| 8| 1| 0| 1| 1| 1| 1| 4|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |     A      |
    50MG/KG                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |     L      |
    LOW MALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Epicardium, Alveolar/Bronchiolar     |                                                                          |            |
          Carcinoma, Metastatic, Lung      |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |                X                                                         |          6 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Leukemia Mononuclear                 |                      X                                                   |          5 |
      Neuroblastoma Malignant              |                                                                          |          1 |
      Pheochromocytoma Malignant           |                   X        X                                             |          5 |
      Pheochromocytoma Benign              | X           X                                                            |          8 |
      Pheochromocytoma Benign, Multiple    |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +     +  +                 +                                             |  27        |
      Adenoma                              |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +     M  +                 +                                             |  26        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Pars Distalis, Adenoma               | X        X                                                               |         15 |
      Pars Distalis, Adenoma, Multiple     |                                                                          |          1 |
      Pars Distalis, Leukemia Mononuclear  |                      X                                                   |          2 |
      Pars Intermedia, Adenoma             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      C-Cell, Adenoma                      |       X                                                                  |          7 |
      C-Cell, Carcinoma                    | X                                                                        |          2 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +     +  +                 +                                             |  29        |
      Mesothelioma Malignant               |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +     +  M                 +                                             |  23        |
      Adenoma                              |                                                                          |          4 |
                                            __________________________________________________________________________|____________|
   Prostate                                | +     +  +                 +                                             |  29        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +     +  +                 +                                             |  30        |
      Mesothelioma Malignant               |                                                                          |          1 |
      Schwannoma Malignant, Metastatic,    |                                                                          |            |
           Peripheral Nerve                |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +                                             |  58        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  52                                                               
NTP Experiment-Test: 05041-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 10:44:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 4| 7| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 2| 3| 9| 5| 3| 3| 3| 3| 3| 1|                                            |            |
                                           | 3| 0| 8| 1| 0| 1| 1| 1| 1| 4|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |     A      |
    50MG/KG                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |     L      |
    LOW MALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Adenoma                              |                   X                                                      |          1 |
      Mesothelioma Malignant               |                                                                          |          3 |
      Interstitial Cell, Adenoma           |                                                                          |          4 |
      Interstitial Cell, Adenoma, Multiple | X  X        X  X     X  X  X                                             |         43 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +     +  +                 +                                             |  28        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +     +  +           +     +                                             |  29        |
      Mediastinal, Leukemia Mononuclear    |                                                                          |          1 |
      Mediastinal, Mesothelioma Malignant, |                                                                          |            |
           Metastatic, Mesentery           |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +     +  +           +     +                                             |  28        |
      Leukemia Mononuclear                 |                      X                                                   |          3 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +     +  +           +     +                                             |  28        |
      Leukemia Mononuclear                 |                      X                                                   |          2 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +     +     +     +                                             |  39        |
      Leukemia Mononuclear                 | X              X     X     X                                             |         11 |
      Mesothelioma Malignant               |                                                                          |          2 |
      Schwannoma Malignant, Metastatic,    |                                                                          |            |
           Peripheral Nerve                |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +     +  +           +     +                                             |  28        |
      Leukemia Mononuclear                 |                      X                                                   |          1 |
      Schwannoma Malignant                 |       X                                                                  |          1 |
      Schwannoma Malignant, Metastatic,    |                                                                          |            |
           Peripheral Nerve                |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +     +  +                 +                                             |  25        |
      Fibroadenoma                         |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +     +  +           +     +                                             |  29        |
      Squamous Cell Papilloma              |                                                                          |          1 |
      Subcutaneous Tissue, Fibroma         |          X           X                                                   |          3 |
      Subcutaneous Tissue, Neurofibroma    |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +     +  +                 +                                             |  28        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
      Diaphragm, Alveolar/Bronchiolar      |                                                                          |            |
          Carcinoma, Metastatic, Lung      |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  53                                                               
NTP Experiment-Test: 05041-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 10:44:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 4| 7| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 2| 3| 9| 5| 3| 3| 3| 3| 3| 1|                                            |            |
                                           | 3| 0| 8| 1| 0| 1| 1| 1| 1| 4|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |     A      |
    50MG/KG                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |     L      |
    LOW MALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +     +  +                 +                                             |  27        |
      Oligodendroglioma Benign             |                            X                                             |          1 |
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |                                                                          |   1        |
      Schwannoma Malignant                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +     +  +                 +                                             |  27        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Adenocarcinoma, Metastatic, Salivary |                                                                          |            |
          Glands                           |                                                                          |          1 |
      Alveolar/Bronchiolar Carcinoma       |                                                                          |          1 |
      Leukemia Mononuclear                 | X              X     X                                                   |          9 |
      Mesothelioma Malignant, Metastatic,  |                                                                          |            |
           Mesentery                       |                                                                          |          1 |
      Schwannoma Malignant, Metastatic,    |                                                                          |            |
           Peripheral Nerve                |                                                                          |          1 |
      Pleura, Mediastinum,                 |                                                                          |            |
          Alveolar/Bronchiolar Carcinoma,  |                                                                          |            |
           Metastatic, Lung                |                                                                          |          1 |
      Pleura, Mediastinum, Thymoma         |                                                                          |            |
          Malignant, Metastatic, Thymus    |       X                                                                  |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +     +  +                 +                                             |  28        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   8        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
      Adenoma                              |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +     +  +                 +                                             |  27        |
      Mesothelioma Malignant               |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  54                                                               
NTP Experiment-Test: 05041-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 10:44:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 4| 7| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 2| 3| 9| 5| 3| 3| 3| 3| 3| 1|                                            |            |
                                           | 3| 0| 8| 1| 0| 1| 1| 1| 1| 4|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |     A      |
    50MG/KG                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |     L      |
    LOW MALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Leukemia Mononuclear                 | X              X     X     X                                             |         11 |
      Mesothelioma Malignant               |                                                                          |          3 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  55                                                               
NTP Experiment-Test: 05041-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 10:44:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 7| 1| 7| 7| 7| 5| 4| 7| 7| 7| 7| 7| 7| 7| 6| 6| 3| 7| 7| 7| 6| 6|             
                             DAY ON TEST   | 3| 3| 5| 3| 7| 3| 3| 1| 7| 3| 3| 3| 3| 0| 1| 3| 3| 7| 0| 0| 3| 3| 3| 9| 9|             
                                           | 1| 1| 4| 1| 6| 1| 1| 3| 0| 1| 1| 1| 1| 3| 1| 1| 1| 0| 4| 5| 1| 1| 1| 8| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    100MG/KG                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    HIGHMALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  M  A  +  +  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Leiomyoma                            |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                        X  X                             X|             
                                            __________________________________________________________________________|             
   Mesentery                               |          +              +                 +  +  +                    +   |             
      Mesothelioma Malignant               |                         X                                                |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Mesothelioma Malignant               |                                                                          |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                  +                                       |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                           X                              |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                        X                                 |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Pheochromocytoma Malignant           |                   X                                                      |             
      Pheochromocytoma Benign              |    X              X              X                          X            |             
      Pheochromocytoma Benign, Multiple    |                                           X     X                    X   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M|             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  56                                                               
NTP Experiment-Test: 05041-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 10:44:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 7| 1| 7| 7| 7| 5| 4| 7| 7| 7| 7| 7| 7| 7| 6| 6| 3| 7| 7| 7| 6| 6|             
                             DAY ON TEST   | 3| 3| 5| 3| 7| 3| 3| 1| 7| 3| 3| 3| 3| 0| 1| 3| 3| 7| 0| 0| 3| 3| 3| 9| 9|             
                                           | 1| 1| 4| 1| 6| 1| 1| 3| 0| 1| 1| 1| 1| 3| 1| 1| 1| 0| 4| 5| 1| 1| 1| 8| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    100MG/KG                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    HIGHMALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pars Distalis, Adenoma               | X        X           X              X  X     X                           |             
      Pars Distalis, Carcinoma             |                                                                          |             
      Pars Distalis, Leukemia Mononuclear  |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Adenoma                      |                X  X           X                                          |             
      C-Cell, Carcinoma                    |                   X              X                                       |             
      Follicular Cell, Adenoma, Multiple   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mesothelioma Malignant               |                         X                                               X|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mesothelioma Malignant               |                                                                   X      |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mesothelioma Malignant               |                         X                                         X     X|             
      Interstitial Cell, Adenoma           |                      X  X  X           X                                X|             
      Interstitial Cell, Adenoma, Multiple | X  X  X  X     X  X           X  X        X  X  X  X  X     X  X  X  X   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  M  +  +  M  M  +  +  +  M  +  M  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                           X                              |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                           X                              |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                        X  X                             X|             
      Mesothelioma Malignant               |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  M  +  +  M  M  +  +  +|             
      Leukemia Mononuclear                 |                                           X                              |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  M  +  M  M  +  +  M  M  +  +  +  +  +  +  M  +|             
      Fibroadenoma                         |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basal Cell Carcinoma                 |                                                                          |             
      Keratoacanthoma                      |                                  X  X  X                                 |             
      Subcutaneous Tissue, Fibroma         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  57                                                               
NTP Experiment-Test: 05041-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 10:44:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 7| 1| 7| 7| 7| 5| 4| 7| 7| 7| 7| 7| 7| 7| 6| 6| 3| 7| 7| 7| 6| 6|             
                             DAY ON TEST   | 3| 3| 5| 3| 7| 3| 3| 1| 7| 3| 3| 3| 3| 0| 1| 3| 3| 7| 0| 0| 3| 3| 3| 9| 9|             
                                           | 1| 1| 4| 1| 6| 1| 1| 3| 0| 1| 1| 1| 1| 3| 1| 1| 1| 0| 4| 5| 1| 1| 1| 8| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    100MG/KG                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    HIGHMALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Subcutaneous Tissue,                 |                                                                          |             
          Neurofibrosarcoma                |                                                                          |             
      Subcutaneous Tissue, Sarcoma         |                                                             X            |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                         +                    +                           |             
      Abdominal, Mesothelioma Malignant    |                         X                                                |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Extension                 |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                   X                                                      |             
      Leukemia Mononuclear                 |                                        X  X                             X|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Chondroma                            |                                                    X                     |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |          +        +                                                     +|             
                                            __________________________________________________________________________|             
   Harderian Gland                         |          +                                                              +|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Sarcoma                              |                                                                   X      |             
      Renal Tubule, Adenoma                |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mesothelioma Malignant               |                                                                   X      |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                        X  X                             X|             
      Mesothelioma Malignant               |                         X                                         X     X|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  58                                                               
NTP Experiment-Test: 05041-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 10:44:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 0| 7| 7| 6| 6| 5| 7| 7| 7| 6| 1| 7| 6| 5| 7| 0| 7| 7| 7| 0| 7|             
                             DAY ON TEST   | 3| 3| 3| 2| 9| 3| 1| 6| 0| 1| 3| 3| 3| 7| 8| 3| 3| 3| 3| 6| 2| 3| 3| 8| 3|             
                                           | 1| 1| 1| 5| 6| 1| 9| 2| 3| 5| 1| 1| 1| 9| 5| 1| 9| 3| 1| 8| 3| 1| 1| 2| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    100MG/KG                               | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    HIGHMALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  M  +  +  +  M  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  M  +  +  +  +  +  +  +  +  A  +  +  +  +  +  M  +  +  +  M  +|             
      Leukemia Mononuclear                 |                      X                                                   |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  A  A  +  +  +  +  A  +  +  +  +  +  M  +  +  +  M  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  M  +  +  A  A  +  +  +  +  A  +  +  +  +  +  M  +  +  +  M  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  +  +  +  M  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  A  A  +  +  +  +  A  +  +  +  +  +  M  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  M  +  +  A  A  +  +  +  +  A  +  +  +  +  +  M  +  +  +  M  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  M  +  +  A  A  +  +  +  +  A  +  +  +  +  +  M  +  +  +  M  +|             
      Leiomyoma                            |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X                    X     X           X        X              X        X|             
                                            __________________________________________________________________________|             
   Mesentery                               |                               +              +        +                  |             
      Mesothelioma Malignant               |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                            X                                             |             
      Mesothelioma Malignant               |                                  X                                       |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |    +                                                                     |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                      X     X                                             |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X                          X           X                       X         |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Pheochromocytoma Malignant           |                                                                          |             
      Pheochromocytoma Benign              |    X     X        X           X                             X            |             
      Pheochromocytoma Benign, Multiple    |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                X         |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  M  +  +  M  +  M  +  +  M  +  +  M  M  +  +  +  +  +|             
      Adenoma                              |                                                             X            |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  59                                                               
NTP Experiment-Test: 05041-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 10:44:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 0| 7| 7| 6| 6| 5| 7| 7| 7| 6| 1| 7| 6| 5| 7| 0| 7| 7| 7| 0| 7|             
                             DAY ON TEST   | 3| 3| 3| 2| 9| 3| 1| 6| 0| 1| 3| 3| 3| 7| 8| 3| 3| 3| 3| 6| 2| 3| 3| 8| 3|             
                                           | 1| 1| 1| 5| 6| 1| 9| 2| 3| 5| 1| 1| 1| 9| 5| 1| 9| 3| 1| 8| 3| 1| 1| 2| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    100MG/KG                               | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    HIGHMALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pars Distalis, Adenoma               |    X     X        X           X                    X                     |             
      Pars Distalis, Carcinoma             |                         X                                                |             
      Pars Distalis, Leukemia Mononuclear  |                      X                                                   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Adenoma                      |                X  X                                                      |             
      C-Cell, Carcinoma                    |                                                                          |             
      Follicular Cell, Adenoma, Multiple   |                   X                                                      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mesothelioma Malignant               |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  A  +  +  +  +  +  M  +  +  +  +  +  M  +  M  +  M  +|             
      Adenoma                              |                                     X                                    |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  M  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Mesothelioma Malignant               |                                  X                                       |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mesothelioma Malignant               |                                  X                                       |             
      Interstitial Cell, Adenoma           |                X                                                         |             
      Interstitial Cell, Adenoma, Multiple | X  X  X           X     X  X  X  X  X  X     X  X     X     X  X  X     X|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Leukemia Mononuclear                 |                      X                 X                                 |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X                    X     X           X        X              X        X|             
      Mesothelioma Malignant               |                                  X                                       |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  +  +  +  +  +  +  +  +  +  M  +  A  +  +  M  +  +  +  +  M  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  M  M  +  +  M  M  +  M  +  M  +  M  +  +  M  M  +  +  +  +  M|             
      Fibroadenoma                         | X                                                                        |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Basal Cell Carcinoma                 |    X                                                                     |             
      Keratoacanthoma                      |                X                 X                             X         |             
      Subcutaneous Tissue, Fibroma         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  60                                                               
NTP Experiment-Test: 05041-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 10:44:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 0| 7| 7| 6| 6| 5| 7| 7| 7| 6| 1| 7| 6| 5| 7| 0| 7| 7| 7| 0| 7|             
                             DAY ON TEST   | 3| 3| 3| 2| 9| 3| 1| 6| 0| 1| 3| 3| 3| 7| 8| 3| 3| 3| 3| 6| 2| 3| 3| 8| 3|             
                                           | 1| 1| 1| 5| 6| 1| 9| 2| 3| 5| 1| 1| 1| 9| 5| 1| 9| 3| 1| 8| 3| 1| 1| 2| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    100MG/KG                               | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    HIGHMALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Subcutaneous Tissue,                 |                                                                          |             
          Neurofibrosarcoma                |                                                                         X|             
      Subcutaneous Tissue, Sarcoma         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Abdominal, Mesothelioma Malignant    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Extension                 |                         X                                                |             
      Leukemia Mononuclear                 |                            X                                             |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                                                          |             
      Leukemia Mononuclear                 | X                    X     X           X        X              X         |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Chondroma                            |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |    +              +                                +                     |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                            X           X                                 |             
      Sarcoma                              |                                                                          |             
      Renal Tubule, Adenoma                |                                                                   X      |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Mesothelioma Malignant               |                                  X                                       |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X                    X     X           X        X              X        X|             
      Mesothelioma Malignant               |                                  X                                       |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  61                                                               
NTP Experiment-Test: 05041-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 10:44:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 4| 2|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 1| 6| 0|                                            |            |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 3| 9|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |     A      |
    100MG/KG                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |     L      |
    HIGHMALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  A                                             |  54        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  A                                             |  53        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  A                                             |  51        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  A                                             |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  A                                             |  54        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  A                                             |  53        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  A                                             |  51        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  A                                             |  51        |
      Leiomyoma                            |             X                                                            |          1 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 | X     X                                                                  |         12 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |       +        +        +                                                |  12        |
      Mesothelioma Malignant               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Mesothelioma Malignant               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pharynx                                 |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  58        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  M  +  +  +                                             |  58        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Leukemia Mononuclear                 |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Leukemia Mononuclear                 |                                                                          |          5 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  M  +  +                                             |  58        |
      Leukemia Mononuclear                 |       X                                                                  |          1 |
      Pheochromocytoma Malignant           |                   X                                                      |          2 |
      Pheochromocytoma Benign              |                                                                          |          9 |
      Pheochromocytoma Benign, Multiple    |                                                                          |          3 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  62                                                               
NTP Experiment-Test: 05041-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 10:44:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 4| 2|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 1| 6| 0|                                            |            |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 3| 9|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |     A      |
    100MG/KG                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |     L      |
    HIGHMALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Adenoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  M                                             |  51        |
      Adenoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Pars Distalis, Adenoma               | X              X                                                         |         13 |
      Pars Distalis, Carcinoma             |                                                                          |          1 |
      Pars Distalis, Leukemia Mononuclear  |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      C-Cell, Adenoma                      |                                                                          |          5 |
      C-Cell, Carcinoma                    |                                                                          |          2 |
      Follicular Cell, Adenoma, Multiple   |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Mesothelioma Malignant               |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  M  M  +  +                                             |  51        |
      Adenoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  A                                             |  58        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  A                                             |  57        |
      Mesothelioma Malignant               |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Mesothelioma Malignant               |                                                                          |          4 |
      Interstitial Cell, Adenoma           |                                                                          |          6 |
      Interstitial Cell, Adenoma, Multiple | X  X  X  X  X  X  X  X                                                   |         42 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  M  M  +                                             |  51        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Leukemia Mononuclear                 |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 | X                                                                        |         11 |
      Mesothelioma Malignant               |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  63                                                               
NTP Experiment-Test: 05041-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 10:44:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 4| 2|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 1| 6| 0|                                            |            |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 3| 9|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |     A      |
    100MG/KG                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |     L      |
    HIGHMALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  M  +  +  +  +                                             |  48        |
      Leukemia Mononuclear                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  M  +  +  +  M  +  +  +  +                                             |  42        |
      Fibroadenoma                         |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Basal Cell Carcinoma                 |                                                                          |          1 |
      Keratoacanthoma                      |                                                                          |          6 |
      Subcutaneous Tissue, Fibroma         |          X     X                                                         |          2 |
      Subcutaneous Tissue,                 |                                                                          |            |
          Neurofibrosarcoma                |                                                                          |          1 |
      Subcutaneous Tissue, Sarcoma         |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   2        |
      Abdominal, Mesothelioma Malignant    |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Carcinoma, Extension                 |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Alveolar/Bronchiolar Adenoma         |                                                                          |          1 |
      Leukemia Mononuclear                 |       X                                                                  |         10 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  A                                             |  59        |
      Chondroma                            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  59        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     | +                 +                                                      |   8        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                   +                                                      |   3        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  64                                                               
NTP Experiment-Test: 05041-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 10:44:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 4| 2|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 1| 6| 0|                                            |            |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 3| 9|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |     A      |
    100MG/KG                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |     L      |
    HIGHMALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Leukemia Mononuclear                 |                                                                          |          2 |
      Sarcoma                              |                                                                          |          1 |
      Renal Tubule, Adenoma                |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Mesothelioma Malignant               |                                                                          |          2 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 | X     X                                                                  |         12 |
      Mesothelioma Malignant               |                                                                          |          4 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  65                                                               
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