National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/3474

TR 373 Rat Pathology Tables


                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                         SUCCINIC ANHYDRIDE


NTP Experiment-Test: 05041-01                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 09/05/94
Route: GAVAGE                                                                                                     Time: 13:16:48




       Facility:  Microbiological Associates

       Chemical CAS #:  108-30-5

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05041-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 13:16:48  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      50MG/KG      100MG/KG                                               
                                                   FEMALE       LOW FEM       HIGHFEM                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          60           60           60                                                  
  Early Deaths                                                                                                                      
    Dead                                              10           11           10                                                  
    Moribund                                          18           15           14                                                  
    Gavage Death                                       1            6            9                                                  
    Accident                                                        1                                                               
  Survivors                                                                                                                         
    Terminal Sacrifice                                30           27           26                                                  
    Dead                                                                         1                                                  
    Moribund                                           1                                                                            
  Animals Examined Microscopically                    60           60           60                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (54)         (35)         (53)                                                
      Adenocarcinoma, Extension                        1 (2%)                                                                       
   Intestine Large, Colon                             (55)         (44)         (55)                                                
      Adenocarcinoma, Extension                        1 (2%)                                                                       
      Sarcoma Stromal, Metastatic, Uterus                           1 (2%)                                                          
   Intestine Small, Duodenum                          (55)         (44)         (52)                                                
      Adenocarcinoma, Extension                        1 (2%)                                                                       
   Intestine Small, Ileum                             (53)         (35)         (51)                                                
   Liver                                              (60)         (52)         (60)                                                
      Adenocarcinoma, Extension                        1 (2%)                                                                       
      Neoplastic Nodule                                2 (3%)       1 (2%)       2 (3%)                                             
      Neoplastic Nodule, Multiple                                                1 (2%)                                             
   Mesentery                                          (6)          (6)          (3)                                                 
      Adenocarcinoma, Extension                        1 (17%)                                                                      
      Sarcoma, Metastatic, Skeletal Muscle             1 (17%)                                                                      
   Pancreas                                           (59)         (44)         (59)                                                
      Adenocarcinoma, Extension                        1 (2%)                                                                       
   Salivary Glands                                    (60)         (45)         (59)                                                
   Stomach, Forestomach                               (58)         (44)         (57)                                                
      Squamous Cell Papilloma                                       1 (2%)                                                          
   Stomach, Glandular                                 (58)         (45)         (54)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (60)         (45)         (60)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   2                                                               
NTP Experiment-Test: 05041-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 13:16:48  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      50MG/KG      100MG/KG                                               
                                                   FEMALE       LOW FEM       HIGHFEM                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (60)         (45)         (59)                                                
      Adenocarcinoma, Extension                        1 (2%)                                                                       
      Adenoma, Multiple                                1 (2%)                                                                       
      Carcinoma                                                     1 (2%)                                                          
   Adrenal Gland, Medulla                             (59)         (43)         (54)                                                
      Pheochromocytoma Malignant                       1 (2%)                                                                       
      Pheochromocytoma Benign                          2 (3%)       1 (2%)       3 (6%)                                             
      Pheochromocytoma Benign, Multiple                1 (2%)                                                                       
   Pituitary Gland                                    (60)         (55)         (60)                                                
      Pars Distalis, Adenoma                          27 (45%)     25 (45%)     18 (30%)                                            
      Pars Distalis, Adenoma, Multiple                 3 (5%)       1 (2%)       2 (3%)                                             
      Pars Distalis, Carcinoma                         1 (2%)                    1 (2%)                                             
   Thyroid Gland                                      (59)         (45)         (60)                                                
      C-Cell, Adenoma                                  5 (8%)       2 (4%)       5 (8%)                                             
      C-Cell, Carcinoma                                4 (7%)       2 (4%)       3 (5%)                                             
      Follicular Cell, Adenoma                                                   1 (2%)                                             
      Follicular Cell, Carcinoma                       1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (39)         (27)         (53)                                                
      Adenoma                                          2 (5%)       2 (7%)       3 (6%)                                             
      Squamous Cell Papilloma, Multiple                1 (3%)                                                                       
   Ovary                                              (59)         (44)         (60)                                                
      Adenocarcinoma, Metastatic, Uterus               1 (2%)                                                                       
      Luteoma                                                       1 (2%)                                                          
      Squamous Cell Carcinoma, Metastatic, Skin                                  1 (2%)                                             
   Uterus                                             (59)         (48)         (60)                                                
      Adenocarcinoma                                   1 (2%)                                                                       
      Hemangiosarcoma                                               1 (2%)                                                          
      Leiomyosarcoma                                                1 (2%)                                                          
      Sarcoma                                          1 (2%)                                                                       
      Sarcoma Stromal                                                            1 (2%)                                             
      Squamous Cell Carcinoma, Metastatic, Skin                                  1 (2%)                                             
      Endometrium, Polyp Stromal                      11 (19%)      8 (17%)      6 (10%)                                            
      Endometrium, Polyp Stromal, Multiple                                       3 (5%)                                             
      Endometrium, Sarcoma Stromal                                  1 (2%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   3                                                               
NTP Experiment-Test: 05041-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 13:16:48  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      50MG/KG      100MG/KG                                               
                                                   FEMALE       LOW FEM       HIGHFEM                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (60)         (45)         (60)                                                
   Lymph Node                                         (59)         (45)         (60)                                                
      Adenocarcinoma, Metastatic, Uterus               1 (2%)                                                                       
   Lymph Node, Mandibular                             (54)         (43)         (55)                                                
   Lymph Node, Mesenteric                             (59)         (43)         (59)                                                
   Spleen                                             (59)         (46)         (60)                                                
   Thymus                                             (48)         (41)         (52)                                                
      Squamous Cell Carcinoma, Metastatic, Skin                                  1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (59)         (55)         (59)                                                
      Adenocarcinoma                                                2 (4%)       2 (3%)                                             
      Adenoma                                          1 (2%)       2 (4%)                                                          
      Fibroadenoma                                    17 (29%)     17 (31%)     12 (20%)                                            
      Fibroadenoma, Multiple                           8 (14%)      6 (11%)                                                         
   Skin                                               (60)         (44)         (60)                                                
      Sarcoma                                                       1 (2%)                                                          
      Squamous Cell Carcinoma                                                    1 (2%)                                             
      Head, Sebaceous Gland, Adenoma                   1 (2%)                                                                       
      Subcutaneous Tissue, Fibroma                                               1 (2%)                                             
      Subcutaneous Tissue, Fibrosarcoma                                          1 (2%)                                             
      Subcutaneous Tissue, Lipoma                      1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                    (1)                       (1)                                                 
      Sarcoma                                          1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (60)         (45)         (60)                                                
      Astrocytoma Benign                                                         1 (2%)                                             
      Carcinoma                                        1 (2%)                                                                       
      Ependymoma Benign                                                          1 (2%)                                             
      Oligodendroglioma Benign                         1 (2%)                                                                       
   Spinal Cord                                        (1)                       (1)                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   4                                                               
NTP Experiment-Test: 05041-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 13:16:48  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      50MG/KG      100MG/KG                                               
                                                   FEMALE       LOW FEM       HIGHFEM                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (49)         (60)                                                
      Adenocarcinoma, Metastatic, Uterus               1 (2%)                                                                       
      Alveolar/Bronchiolar Adenoma                     3 (5%)       1 (2%)                                                          
      Sarcoma, Metastatic, Skeletal Muscle             1 (2%)                                                                       
      Squamous Cell Carcinoma, Metastatic, Skin                                  1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Zymbal's Gland                                     (1)                                                                           
      Squamous Cell Carcinoma                          1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (59)         (60)                                                
      Nephroblastoma                                                2 (3%)                                                          
      Squamous Cell Carcinoma, Metastatic, Skin                                  1 (2%)                                             
   Urinary Bladder                                    (56)         (41)         (60)                                                
      Leiomyosarcoma                                                1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(60)        *(60)        *(60)                                                
      Leukemia Mononuclear                            11 (18%)      6 (10%)      8 (13%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   5                                                               
NTP Experiment-Test: 05041-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 13:16:48  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      50MG/KG      100MG/KG                                               
                                                   FEMALE       LOW FEM       HIGHFEM                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            55          47          39                                                   
     Total Primary Neoplasms                          117          86          77                                                   
                                                                                                                                    
   Total Animals with Benign Neoplasms                 52          42          34                                                   
     Total Benign Neoplasms                            87          68          59                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms              21          15          18                                                   
     Total Malignant Neoplasms                         30          18          18                                                   
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              2           1           1                                                   
     Total Metastatic Neoplasm                          5           1           5                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   6                                                               
NTP Experiment-Test: 05041-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 13:16:48  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      50MG/KG      100MG/KG                                               
                                                   MALE         LOW MALE     HIGHMALE                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          60           60           60                                                  
  Early Deaths                                                                                                                      
    Moribund                                          15           16           10                                                  
    Dead                                               8            9           14                                                  
    Gavage Death                                       1            2            4                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                36           33           32                                                  
  Animals Examined Microscopically                    60           60           60                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (60)         (28)         (60)                                                
      Leiomyosarcoma                                   1 (2%)                                                                       
   Intestine Large, Cecum                             (52)         (24)         (53)                                                
      Lipoma                                           1 (2%)                                                                       
   Intestine Small, Duodenum                          (52)         (24)         (53)                                                
      Leiomyosarcoma                                                1 (4%)                                                          
   Intestine Small, Ileum                             (53)         (24)         (51)                                                
      Leiomyosarcoma                                   1 (2%)                                                                       
   Intestine Small, Jejunum                           (52)         (23)         (51)                                                
      Leiomyoma                                                                  1 (2%)                                             
   Liver                                              (60)         (47)         (60)                                                
      Neoplastic Nodule                                1 (2%)                                                                       
      Schwannoma Malignant, Metastatic, Peripheral                                                                                  
          Nerve                                                     1 (2%)                                                          
   Mesentery                                          (13)         (14)         (12)                                                
      Fibrosarcoma                                                  1 (7%)                                                          
      Sarcoma                                                       1 (7%)                                                          
      Schwannoma Malignant, Metastatic, Peripheral                                                                                  
          Nerve                                                     1 (7%)                                                          
   Pancreas                                           (59)         (26)         (59)                                                
      Schwannoma Malignant, Metastatic, Peripheral                                                                                  
          Nerve                                                     1 (4%)                                                          
   Salivary Glands                                    (58)         (27)         (58)                                                
      Adenocarcinoma                                                1 (4%)                                                          
      Sarcoma                                          1 (2%)       1 (4%)                                                          
   Stomach, Forestomach                               (59)         (29)         (58)                                                
   Stomach, Glandular                                 (58)         (31)         (59)                                                
   Tooth                                                           (1)          (1)                                                 
      Neoplasm NOS                                                  1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   7                                                               
NTP Experiment-Test: 05041-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 13:16:48  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      50MG/KG      100MG/KG                                               
                                                   MALE         LOW MALE     HIGHMALE                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (60)         (29)         (59)                                                
      Adenocarcinoma, Metastatic, Salivary Glands                   1 (3%)                                                          
      Osteosarcoma, Metastatic, Bone                   1 (2%)                                                                       
      Endocardium, Schwannoma Malignant                             1 (3%)                                                          
      Epicardium, Alveolar/Bronchiolar Carcinoma,                                                                                   
           Metastatic, Lung                                         1 (3%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (60)         (60)         (59)                                                
      Carcinoma                                        1 (2%)                                                                       
      Osteosarcoma, Metastatic, Bone                   1 (2%)                                                                       
   Adrenal Gland, Medulla                             (58)         (58)         (58)                                                
      Neuroblastoma Malignant                                       1 (2%)                                                          
      Pheochromocytoma Malignant                       4 (7%)       5 (9%)       2 (3%)                                             
      Pheochromocytoma Benign                         14 (24%)      8 (14%)      9 (16%)                                            
      Pheochromocytoma Benign, Multiple                3 (5%)       1 (2%)       3 (5%)                                             
      Bilateral, Pheochromocytoma Malignant            1 (2%)                                                                       
   Islets, Pancreatic                                 (59)         (27)         (60)                                                
      Adenoma                                                       2 (7%)       1 (2%)                                             
      Adenoma, Multiple                                1 (2%)                                                                       
      Carcinoma                                        1 (2%)                                                                       
   Parathyroid Gland                                  (51)         (26)         (51)                                                
      Adenoma                                          1 (2%)                    1 (2%)                                             
   Pituitary Gland                                    (57)         (59)         (60)                                                
      Pars Distalis, Adenoma                          19 (33%)     15 (25%)     13 (22%)                                            
      Pars Distalis, Adenoma, Multiple                 1 (2%)       1 (2%)                                                          
      Pars Distalis, Carcinoma                                                   1 (2%)                                             
      Pars Intermedia, Adenoma                         1 (2%)       1 (2%)                                                          
   Thyroid Gland                                      (60)         (60)         (58)                                                
      C-Cell, Adenoma                                  7 (12%)      7 (12%)      5 (9%)                                             
      C-Cell, Carcinoma                                6 (10%)      2 (3%)       2 (3%)                                             
      Follicular Cell, Adenoma                         1 (2%)                                                                       
      Follicular Cell, Adenoma, Multiple                                         1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                         (2)                                                                           
      Schwannoma Malignant, Metastatic, Spinal Cord    1 (50%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   8                                                               
NTP Experiment-Test: 05041-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 13:16:48  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      50MG/KG      100MG/KG                                               
                                                   MALE         LOW MALE     HIGHMALE                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (60)         (29)         (59)                                                
   Preputial Gland                                    (48)         (23)         (51)                                                
      Adenoma                                                       4 (17%)      1 (2%)                                             
   Seminal Vesicle                                    (59)         (30)         (57)                                                
      Schwannoma Malignant, Metastatic, Peripheral                                                                                  
          Nerve                                                     1 (3%)                                                          
   Testes                                             (60)         (58)         (60)                                                
      Adenoma                                                       1 (2%)                                                          
      Interstitial Cell, Adenoma                       8 (13%)      4 (7%)       6 (10%)                                            
      Interstitial Cell, Adenoma, Multiple            48 (80%)     43 (74%)     42 (70%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node                                         (60)         (29)         (60)                                                
   Lymph Node, Mandibular                             (50)         (28)         (51)                                                
   Lymph Node, Mesenteric                             (57)         (28)         (59)                                                
   Spleen                                             (59)         (39)         (60)                                                
      Hemangiosarcoma                                  1 (2%)                                                                       
      Schwannoma Malignant, Metastatic, Peripheral                                                                                  
          Nerve                                                     1 (3%)                                                          
   Thymus                                             (45)         (28)         (48)                                                
      Schwannoma Malignant                                          1 (4%)                                                          
      Schwannoma Malignant, Metastatic, Peripheral                                                                                  
          Nerve                                                     1 (4%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (48)         (25)         (42)                                                
      Adenoma                                          1 (2%)                                                                       
      Fibroadenoma                                     1 (2%)       2 (8%)       1 (2%)                                             
   Skin                                               (60)         (29)         (59)                                                
      Basal Cell Carcinoma                             1 (2%)                    1 (2%)                                             
      Keratoacanthoma                                  2 (3%)                    6 (10%)                                            
      Squamous Cell Papilloma                          2 (3%)       1 (3%)                                                          
      Trichoepithelioma                                2 (3%)                                                                       
      Subcutaneous Tissue, Fibroma                     3 (5%)       3 (10%)      2 (3%)                                             
      Subcutaneous Tissue, Myxosarcoma                 1 (2%)                                                                       
      Subcutaneous Tissue, Neurofibroma                             1 (3%)                                                          
      Subcutaneous Tissue, Neurofibrosarcoma                                     1 (2%)                                             
      Subcutaneous Tissue, Sarcoma                                               1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   9                                                               
NTP Experiment-Test: 05041-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 13:16:48  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      50MG/KG      100MG/KG                                               
                                                   MALE         LOW MALE     HIGHMALE                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (60)         (28)         (60)                                                
      Femur, Osteosarcoma                              1 (2%)                                                                       
      Vertebra, Osteosarcoma                           1 (2%)                                                                       
   Skeletal Muscle                                                 (1)          (2)                                                 
      Diaphragm, Alveolar/Bronchiolar Carcinoma,                                                                                    
           Metastatic, Lung                                         1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (60)         (27)         (60)                                                
      Carcinoma, Extension                                                       1 (2%)                                             
      Glioma Benign                                    1 (2%)                                                                       
      Oligodendroglioma Benign                                      1 (4%)                                                          
      Cerebrum, Glioma Benign                          1 (2%)                                                                       
   Peripheral Nerve                                                (1)                                                              
      Schwannoma Malignant                                          1 (100%)                                                        
   Spinal Cord                                        (3)                                                                           
      Schwannoma Malignant                             1 (33%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (60)         (60)                                                
      Adenocarcinoma, Metastatic, Salivary Glands                   1 (2%)                                                          
      Alveolar/Bronchiolar Adenoma                     2 (3%)                    1 (2%)                                             
      Alveolar/Bronchiolar Carcinoma                                1 (2%)                                                          
      Osteosarcoma, Metastatic, Bone                   1 (2%)                                                                       
      Sarcoma, Metastatic, Salivary Glands             1 (2%)                                                                       
      Schwannoma Malignant, Metastatic, Peripheral                                                                                  
          Nerve                                                     1 (2%)                                                          
      Pleura, Mediastinum, Alveolar/Bronchiolar                                                                                     
          Carcinoma, Metastatic, Lung                               1 (2%)                                                          
      Pleura, Mediastinum, Thymoma Malignant,                                                                                       
          Metastatic, Thymus                                        1 (2%)                                                          
   Nose                                               (58)         (59)         (59)                                                
      Chondroma                                                                  1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Zymbal's Gland                                                  (1)                                                              
      Adenoma                                                       1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page  10                                                               
NTP Experiment-Test: 05041-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 13:16:48  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      50MG/KG      100MG/KG                                               
                                                   MALE         LOW MALE     HIGHMALE                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (60)         (59)                                                
      Osteosarcoma, Metastatic, Bone                   1 (2%)                                                                       
      Sarcoma                                                                    1 (2%)                                             
      Renal Tubule, Adenoma                            1 (2%)                    1 (2%)                                             
   Urinary Bladder                                    (59)         (27)         (59)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(60)        *(60)        *(60)                                                
      Leukemia Mononuclear                            13 (22%)     11 (18%)     12 (20%)                                            
      Mesothelioma Malignant                           2 (3%)       3 (5%)       4 (7%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  11                                                               
NTP Experiment-Test: 05041-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 13:16:48  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      50MG/KG      100MG/KG                                               
                                                   MALE         LOW MALE     HIGHMALE                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            60          57          52                                                   
     Total Primary Neoplasms                          159         128         121                                                   
                                                                                                                                    
   Total Animals with Benign Neoplasms                 59          56          51                                                   
     Total Benign Neoplasms                           122          96          95                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms              30          28          21                                                   
     Total Malignant Neoplasms                         37          31          26                                                   
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              3           5                                                               
     Total Metastatic Neoplasm                          6          15                                                               
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                              1                                                               
     Total Uncertain Neoplasms                                      1                                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  12                                                               
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