National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/3478

TR 373 Rat Pathology Tables

NTP Experiment-Test: 05041-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 05/01/97
Route: GAVAGE                                                                                                     Time: 11:52:17




       Facility:  Microbiological Associates

       Chemical CAS #:  108-30-5

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All






































                                                              Page   1

NTP Experiment-Test: 05041-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 11:52:17  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 5| 6| 7| 7| 6| 5| 7| 7| 7| 5| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 2| 2| 2| 9| 7| 0| 1| 2| 4| 0| 2| 2| 2| 1| 6| 2| 2| 2| 2| 2| 3| 3| 3| 0| 4|             
                                           | 9| 3| 9| 5| 6| 4| 1| 9| 0| 7| 9| 9| 9| 6| 9| 9| 9| 9| 9| 9| 0| 0| 0| 5| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    CONTROL                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Muscularis, Regeneration             |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  A  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                            3                                             |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  M  A  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                            2                                             |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  A  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  A  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  M  +  +  +  +  A  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  M  +  +  +  +  A  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                   1                                                      |             
      Basophilic Focus, Multiple           |    X              X  X        X                       X     X  X  X      |             
      Cytologic Alterations                |                                  X                                       |             
      Cytologic Alterations, Multiple      |                                                                          |             
      Fibrosis, Focal                      | 2  2                          2                 1                        |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hepatodiaphragmatic Nodule           | X  X                                                                     |             
      Inflammation, Chronic                |                         2     1              2        2  2     1  2      |             
      Necrosis, Focal                      |                                                                          |             
      Vacuolization Cytoplasmic            | 2                                                                        |             
      Bile Duct, Hyperplasia               |       1              1           1  1        1     1              2      |             
      Centrilobular, Vacuolization         |                                                                          |             
          Cytoplasmic                      |                2        2  2                                            2|             
                                            __________________________________________________________________________|             
   Mesentery                               | +        +  +                                                        +   |             
      Fat, Necrosis                        | 3        2                                                           2   |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectopic Tissue                       |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Acinus, Atrophy, Diffuse             |                                                                      4   |             
      Acinus, Atrophy, Focal               |                      1           1                 1              1      |             
      Acinus, Hyperplasia                  |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                                       2                  |             
      Inflammation, Chronic                |                1                                      1              2   |             
      Epithelium, Hyperplasia              |                                                                      2   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                1                                                         |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05041-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 11:52:17  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 5| 6| 7| 7| 6| 5| 7| 7| 7| 5| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 2| 2| 2| 9| 7| 0| 1| 2| 4| 0| 2| 2| 2| 1| 6| 2| 2| 2| 2| 2| 3| 3| 3| 0| 4|             
                                           | 9| 3| 9| 5| 6| 4| 1| 9| 0| 7| 9| 9| 9| 6| 9| 9| 9| 9| 9| 9| 0| 0| 0| 5| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    CONTROL                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                           +                              |             
      Foreign Body                         |                                           2                              |             
      Aorta, Inflammation, Chronic Active  |                                           4                              |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1        1        1     1  1     2  2  1     2     1  1  2  1  1  2  2   |             
      Epicardium, Inflammation, Chronic    |                                                                          |             
          Active                           |                                           4                              |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia                          | 2                                                                    1   |             
      Necrosis, Focal                      |                            2                                             |             
      Vacuolization Cytoplasmic, Focal     |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |       2                          1              1           3           1|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  M  +  +  +  M  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                                     2           2                        |             
      Pars Distalis, Concretion            |                                                                          |             
      Pars Distalis, Cyst                  |                            1                                             |             
      Pars Distalis, Degeneration, Focal   |                                              2                           |             
      Pars Distalis, Hyperplasia           |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |       1                                            1     2        1      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  M  +  +  M  +  M  +  +  +  M  M  +  +  +  +  M  +  M  M  M  +  +  +  +|             
      Dilatation                           |                      2                             2                     |             
      Hyperplasia                          |                                                                      2   |             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |       2                                               2        2         |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Endometrium, Hyperplasia, Cystic     |             2        2                                   2               |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05041-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 11:52:17  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 5| 6| 7| 7| 6| 5| 7| 7| 7| 5| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 2| 2| 2| 9| 7| 0| 1| 2| 4| 0| 2| 2| 2| 1| 6| 2| 2| 2| 2| 2| 3| 3| 3| 0| 4|             
                                           | 9| 3| 9| 5| 6| 4| 1| 9| 0| 7| 9| 9| 9| 6| 9| 9| 9| 9| 9| 9| 0| 0| 0| 5| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    CONTROL                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Hyperplasia, Reticulum Cell          |                                              2                           |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Hemorrhage                           |                   2                                                      |             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                                         2|             
      Pigmentation                         |       1                 1  3           1                          1      |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  M  +  +  M  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |       3                 2     2                                          |             
      Hyperplasia                          |    2                                                                     |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cranium, Femur, Hyperostosis         |                                                                3         |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                                          |             
      Thrombosis, Focal                    |                                                 2                        |             
      Thalamus, Compression                |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                 +                        |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                   3                                                      |             
      Foreign Body                         |                                        2                                 |             
      Hemorrhage                           |                                        2                                 |             
      Hyperplasia, Adenomatous             |                                                                          |             
      Infiltration Cellular, Histiocyte    | 1     1              1     1     1  1                       1  1        1|             
      Inflammation, Acute                  |                                        3                                 |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Mediastinum, Foreign Body            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05041-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 11:52:17  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 5| 6| 7| 7| 6| 5| 7| 7| 7| 5| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 2| 2| 2| 9| 7| 0| 1| 2| 4| 0| 2| 2| 2| 1| 6| 2| 2| 2| 2| 2| 3| 3| 3| 0| 4|             
                                           | 9| 3| 9| 5| 6| 4| 1| 9| 0| 7| 9| 9| 9| 6| 9| 9| 9| 9| 9| 9| 0| 0| 0| 5| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    CONTROL                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Mediastinum, Inflammation, Acute     |                                                                          |             
      Mediastinum, Inflammation, Chronic   |                                                                          |             
          Active                           |                                           4                              |             
      Pleura, Inflammation, Chronic        |                                           2                              |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Sinus, Foreign Body                  |                                                                          |             
      Sinus, Fungus                        |                                                                          |             
      Sinus, Inflammation, Acute           |                                                                          |             
      Turbinate, Inflammation, Chronic     |                                                                         1|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |    A                                            +                        |             
      Abscess                              |                                                                          |             
      Lens Capsule, Cataract               |                                                                          |             
      Retina, Atrophy                      |                                                 2                        |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Mineralization                       |                                                                          |             
      Nephropathy                          | 1                       1        1  1        1           1     1         |             
      Papilla, Necrosis                    |             3                                                            |             
      Pelvis, Dilatation                   |             3                                                            |             
      Pelvis, Mineralization               |                            2  1        1                                 |             
      Renal Tubule, Vacuolization          |                                                                          |             
          Cytoplasmic                      |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                    2                     |             
      Hyperplasia                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05041-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 11:52:17  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 6| 5| 0| 7| 7| 7| 6| 4|             
                             DAY ON TEST   | 2| 3| 3| 1| 1| 7| 3| 3| 1| 1| 3| 3| 3| 3| 2| 3| 3| 0| 5| 7| 3| 3| 0| 4| 9|             
                                           | 6| 0| 0| 5| 6| 0| 0| 0| 9| 1| 0| 0| 0| 0| 0| 0| 0| 6| 3| 7| 0| 0| 5| 2| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    CONTROL                                | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Muscularis, Regeneration             |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  A  +|             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |       2                                                                  |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus, Multiple           | X                    X     X  X  X  X  X     X  X           X  X  X  X   |             
      Cytologic Alterations                |                                                                          |             
      Cytologic Alterations, Multiple      |                      X                                                   |             
      Fibrosis, Focal                      | 2                                                                        |             
      Hematopoietic Cell Proliferation     |          1                                                               |             
      Hepatodiaphragmatic Nodule           | X                       X                                                |             
      Inflammation, Chronic                |       2           2  2           1  2        2  1                 1      |             
      Necrosis, Focal                      |                                                                          |             
      Vacuolization Cytoplasmic            |          1  3              2                       4                     |             
      Bile Duct, Hyperplasia               | 2  1                 2  1                             2        2     1   |             
      Centrilobular, Vacuolization         |                                                                          |             
          Cytoplasmic                      |                                                                   2      |             
                                            __________________________________________________________________________|             
   Mesentery                               |          +                                         +                     |             
      Fat, Necrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectopic Tissue                       |                                     X                                    |             
      Inflammation, Chronic                | 1                                                                        |             
      Acinus, Atrophy, Diffuse             |                                     3                                    |             
      Acinus, Atrophy, Focal               |                               1        1        1                        |             
      Acinus, Hyperplasia                  |       1                                                                  |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Epithelium, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   6                                                               
NTP Experiment-Test: 05041-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 11:52:17  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 6| 5| 0| 7| 7| 7| 6| 4|             
                             DAY ON TEST   | 2| 3| 3| 1| 1| 7| 3| 3| 1| 1| 3| 3| 3| 3| 2| 3| 3| 0| 5| 7| 3| 3| 0| 4| 9|             
                                           | 6| 0| 0| 5| 6| 0| 0| 0| 9| 1| 0| 0| 0| 0| 0| 0| 0| 6| 3| 7| 0| 0| 5| 2| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    CONTROL                                | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
      Foreign Body                         |                                                                          |             
      Aorta, Inflammation, Chronic Active  |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1  1  1  1  1     2     1     1  1              1  2        1  1  1  1  1|             
      Epicardium, Inflammation, Chronic    |                                                                          |             
          Active                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                           2                              |             
      Hematopoietic Cell Proliferation     |          1                                                               |             
      Hyperplasia                          |             2                                2                           |             
      Necrosis, Focal                      |                                                                2         |             
      Vacuolization Cytoplasmic, Focal     |                                                                   3      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    1        1     1                                            2         |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  M  M  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  M  +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           | 2                    2           1  2                       2            |             
      Pars Distalis, Concretion            | 2                                                                        |             
      Pars Distalis, Cyst                  | 2           1                                                            |             
      Pars Distalis, Degeneration, Focal   |                                                                          |             
      Pars Distalis, Hyperplasia           |                                                             1            |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |             2                    2  1              1                     |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  M  M  +  +  +  M  +  M  +  M  M  +  +  M  +  +  M  +  +  +  M  M|             
      Dilatation                           |                                                                          |             
      Hyperplasia                          |                                                                          |             
      Inflammation, Acute                  |                                              2                           |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Cyst                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Hemorrhage                           |                                                                          |             
      Endometrium, Hyperplasia, Cystic     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   7                                                               
NTP Experiment-Test: 05041-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 11:52:17  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 6| 5| 0| 7| 7| 7| 6| 4|             
                             DAY ON TEST   | 2| 3| 3| 1| 1| 7| 3| 3| 1| 1| 3| 3| 3| 3| 2| 3| 3| 0| 5| 7| 3| 3| 0| 4| 9|             
                                           | 6| 0| 0| 5| 6| 0| 0| 0| 9| 1| 0| 0| 0| 0| 0| 0| 0| 6| 3| 7| 0| 0| 5| 2| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    CONTROL                                | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |          3                                               3               |             
      Hyperplasia, Reticulum Cell          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                           2                              |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                         2                                                |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |          2                       2                       1               |             
      Pigmentation                         |                            3                          1                  |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |             2                 3                                   2  3   |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cranium, Femur, Hyperostosis         |                      3                                                   |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |          +                                                               |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                          4               |             
      Thrombosis, Focal                    |                                                                          |             
      Thalamus, Compression                |                                                       2                  |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                       2                  |             
      Foreign Body                         |                                                                          |             
      Hemorrhage                           |                                                       2                  |             
      Hyperplasia, Adenomatous             |                                     1              2  2                  |             
      Infiltration Cellular, Histiocyte    |    1  1           1  1        1  1  1  1  1                 1  1         |             
      Inflammation, Acute                  |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                         3                                                |             
      Mediastinum, Foreign Body            |                                                                   2      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   8                                                               
NTP Experiment-Test: 05041-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 11:52:17  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 6| 5| 0| 7| 7| 7| 6| 4|             
                             DAY ON TEST   | 2| 3| 3| 1| 1| 7| 3| 3| 1| 1| 3| 3| 3| 3| 2| 3| 3| 0| 5| 7| 3| 3| 0| 4| 9|             
                                           | 6| 0| 0| 5| 6| 0| 0| 0| 9| 1| 0| 0| 0| 0| 0| 0| 0| 6| 3| 7| 0| 0| 5| 2| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    CONTROL                                | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Mediastinum, Inflammation, Acute     |                                                                   4      |             
      Mediastinum, Inflammation, Chronic   |                                                                          |             
          Active                           |                                                                          |             
      Pleura, Inflammation, Chronic        |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Sinus, Foreign Body                  |                                        2                                 |             
      Sinus, Fungus                        |                                                                   2      |             
      Sinus, Inflammation, Acute           |                                        1                          2      |             
      Turbinate, Inflammation, Chronic     |          2                                                               |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |    +                                                     +               |             
      Abscess                              |                                                          4               |             
      Lens Capsule, Cataract               |    2                                                                     |             
      Retina, Atrophy                      |    3                                                                     |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                           +                              |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                  1                                       |             
      Mineralization                       |                                  1                                       |             
      Nephropathy                          | 1           1     1  1  1  2  1                    1  1                  |             
      Papilla, Necrosis                    |                                                                          |             
      Pelvis, Dilatation                   |                                                                          |             
      Pelvis, Mineralization               |                                                                   2      |             
      Renal Tubule, Vacuolization          |                                                                          |             
          Cytoplasmic                      |                            2                                             |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Hyperplasia                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   9                                                               
NTP Experiment-Test: 05041-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 11:52:17  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 4| 0| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 3| 6| 7| 0| 2| 3| 3| 3| 0|                                            |            |
                                           | 0| 0| 3| 9| 9| 3| 0| 0| 0| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    CONTROL                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |      L     |
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Muscularis, Regeneration             |             3                                                            |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  A  +  +  +  +  A                                             |  56        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  A  +  +  +  +  A                                             |  54        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  A  +  +  +  +  A                                             |  55        |
      Inflammation, Acute                  |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  A  +  +  +  +  A                                             |  53        |
      Inflammation, Acute                  |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  A  +  +  +  +  A                                             |  56        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  A  +  +  +  +  A                                             |  55        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  A  +  +  +  +  A                                             |  53        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  A  +  +  +  +  A                                             |  53        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Angiectasis                          |                                                                          |      1  1.0|
      Basophilic Focus, Multiple           | X  X              X  X  X  X                                             |     27     |
      Cytologic Alterations                |                                                                          |      1     |
      Cytologic Alterations, Multiple      |                                                                          |      1     |
      Fibrosis, Focal                      |                         1                                                |      6  1.7|
      Hematopoietic Cell Proliferation     |                                                                          |      1  1.0|
      Hepatodiaphragmatic Nodule           |                         X                                                |      5     |
      Inflammation, Chronic                | 2                                                                        |     16  1.7|
      Necrosis, Focal                      |                            1                                             |      1  1.0|
      Vacuolization Cytoplasmic            |                1                                                         |      6  2.2|
      Bile Duct, Hyperplasia               | 1  2           2  2  1                                                   |     19  1.4|
      Centrilobular, Vacuolization         |                                                                          |            |
          Cytoplasmic                      |                                                                          |      5  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   6        |
      Fat, Necrosis                        |                                                                          |      3  2.3|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  A  +  +  +  +  +                                             |  59        |
      Ectopic Tissue                       |                                                                          |      1     |
      Inflammation, Chronic                |                                                                          |      1  1.0|
      Acinus, Atrophy, Diffuse             |                                                                          |      2  3.5|
      Acinus, Atrophy, Focal               |          1        1  2                                                   |     10  1.1|
      Acinus, Hyperplasia                  |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  A  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  A  +  +  +  +  +                                             |  58        |
      Foreign Body                         |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  10                                                               
NTP Experiment-Test: 05041-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 11:52:17  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 4| 0| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 3| 6| 7| 0| 2| 3| 3| 3| 0|                                            |            |
                                           | 0| 0| 3| 9| 9| 3| 0| 0| 0| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    CONTROL                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |      L     |
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Chronic                |                                                                          |      3  1.3|
      Epithelium, Hyperplasia              |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  A  +  +  +  +  +                                             |  58        |
      Inflammation, Chronic                |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   1        |
      Foreign Body                         |                                                                          |      1  2.0|
      Aorta, Inflammation, Chronic Active  |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cardiomyopathy                       | 1     1           1  1  1  1                                             |     38  1.2|
      Epicardium, Inflammation, Chronic    |                                                                          |            |
          Active                           |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Angiectasis                          |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     |                                                                          |      1  1.0|
      Hyperplasia                          |                                                                          |      4  1.8|
      Necrosis, Focal                      |                                                                          |      2  2.0|
      Vacuolization Cytoplasmic, Focal     |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Hyperplasia                          |    1              2                                                      |     11  1.5|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  M  A  M  +  +  +  +                                             |  46        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Pars Distalis, Angiectasis           |       2              1                                                   |      9  1.8|
      Pars Distalis, Concretion            |                                                                          |      1  2.0|
      Pars Distalis, Cyst                  |                         2                                                |      4  1.5|
      Pars Distalis, Degeneration, Focal   |                                                                          |      1  2.0|
      Pars Distalis, Hyperplasia           |    1                                                                     |      2  1.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  A  +  +  +  +  +                                             |  59        |
      C-Cell, Hyperplasia                  |                                                                          |      8  1.4|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  11                                                               
NTP Experiment-Test: 05041-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 11:52:17  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 4| 0| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 3| 6| 7| 0| 2| 3| 3| 3| 0|                                            |            |
                                           | 0| 0| 3| 9| 9| 3| 0| 0| 0| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    CONTROL                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |      L     |
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | M  +  +  +  A  +  +  +  +  +                                             |  39        |
      Dilatation                           |                                                                          |      2  2.0|
      Hyperplasia                          |                                                                          |      1  2.0|
      Inflammation, Acute                  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Cyst                                 |       2                                                                  |      4  2.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Hemorrhage                           |                   2                                                      |      1  2.0|
      Endometrium, Hyperplasia, Cystic     |       2                                                                  |      4  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperplasia                          |          2                                                               |      3  2.7|
      Hyperplasia, Reticulum Cell          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  M  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  M  +  +  +  +  +  M                                             |  54        |
      Hemorrhage                           |                                                                          |      1  2.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  M  +  +  +  +  +  +                                             |  59        |
      Edema                                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  A  +  +  +  +  +                                             |  59        |
      Hematopoietic Cell Proliferation     |       2  2                                                               |      6  1.8|
      Pigmentation                         |    2           2     1                                                   |     10  1.6|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  M  +  +  M  +  +  +  +                                             |  48        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  M  +  +  +  +  +  +                                             |  59        |
      Dilatation                           |                2                                                         |      8  2.4|
      Hyperplasia                          |                   3                                                      |      2  2.5|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cranium, Femur, Hyperostosis         |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Abscess                              |                                                                          |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  12                                                               
NTP Experiment-Test: 05041-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 11:52:17  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 4| 0| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 3| 6| 7| 0| 2| 3| 3| 3| 0|                                            |            |
                                           | 0| 0| 3| 9| 9| 3| 0| 0| 0| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    CONTROL                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |      L     |
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Thrombosis, Focal                    |                                                                          |      1  2.0|
      Thalamus, Compression                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  M  +                                             |  58        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Congestion                           |                                                                          |      2  2.5|
      Foreign Body                         |             2                                                            |      2  2.0|
      Hemorrhage                           |                         2                                                |      3  2.0|
      Hyperplasia, Adenomatous             |       2                                                                  |      4  1.8|
      Infiltration Cellular, Histiocyte    |       1  1           1                                                   |     23  1.0|
      Inflammation, Acute                  |             3                                                            |      2  3.0|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      1  3.0|
      Mediastinum, Foreign Body            |                                                                          |      1  2.0|
      Mediastinum, Inflammation, Acute     |                                                                          |      1  4.0|
      Mediastinum, Inflammation, Chronic   |                                                                          |            |
          Active                           |                                                                          |      1  4.0|
      Pleura, Inflammation, Chronic        |             2                                                            |      2  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  A  +  +  +  +  +                                             |  59        |
      Sinus, Foreign Body                  |                                                                          |      1  2.0|
      Sinus, Fungus                        |                                                                          |      1  2.0|
      Sinus, Inflammation, Acute           |                                                                          |      2  1.5|
      Turbinate, Inflammation, Chronic     |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |             +                                                            |   1        |
                                            __________________________________________________________________________|____________|
   Eye                                     |          +                                                               |   4        |
      Abscess                              |                                                                          |      1  4.0|
      Lens Capsule, Cataract               |                                                                          |      1  2.0|
      Retina, Atrophy                      |          3                                                               |      3  2.7|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cyst                                 |                                                                          |      1  1.0|
      Mineralization                       |                                                                          |      1  1.0|
      Nephropathy                          | 1              1  1  1                                                   |     20  1.1|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  13                                                               
NTP Experiment-Test: 05041-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 11:52:17  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 4| 0| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 3| 6| 7| 0| 2| 3| 3| 3| 0|                                            |            |
                                           | 0| 0| 3| 9| 9| 3| 0| 0| 0| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    CONTROL                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |      L     |
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Papilla, Necrosis                    |                                                                          |      1  3.0|
      Pelvis, Dilatation                   |                                                                          |      1  3.0|
      Pelvis, Mineralization               |    2                                                                     |      5  1.6|
      Renal Tubule, Vacuolization          |                                                                          |            |
          Cytoplasmic                      |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  M  +  +  +                                             |  56        |
      Angiectasis                          |                                                                          |      1  2.0|
      Hyperplasia                          |                3                                                         |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  14                                                               
NTP Experiment-Test: 05041-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 11:52:17  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 4| 0| 0| 7| 0| 0| 0| 0| 7| 7| 7| 7| 0| 7| 6| 6| 1| 0| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 9| 0| 0| 0| 3| 1| 1| 0| 0| 3| 3| 3| 0| 1| 3| 9| 8| 6| 0| 3| 3| 3| 3| 3|             
                                           | 1| 0| 1| 5| 2| 1| 3| 0| 9| 9| 1| 1| 1| 5| 2| 1| 1| 4| 9| 2| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    50 MG/KG                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
     LOW FEM                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +  +  +  +     +  +  +  +           +  +  +  +  +  +  +               |             
      Hemorrhage                           |                                           2                              |             
                                            __________________________________________________________________________|             
   Intestine Large                         |    +  +  +  +     +  +  +  +           +  +  +  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    +  +  M  M     M  M  M  M           +  M  +  +  +  +  M               |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +  +  +  +     +  +  +  +           +  +  +  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +  +  M  M     M  M  M  M           +  M  +  +  +  +  M               |             
                                            __________________________________________________________________________|             
   Intestine Small                         |    +  +  +  +     +  +  +  +           +  +  +  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +  +  +  +     +  +  +  +           +  +  +  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    +  +  M  M     M  M  M  M           +  M  +  +  +  +  M               |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +  +  M  M     M  M  M  M           +  M  +  +  +  +  M               |             
                                            __________________________________________________________________________|             
   Liver                                   |    +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +     +      |             
      Basophilic Focus                     |                               X                                          |             
      Basophilic Focus, Multiple           |                                  X           X  X           X            |             
      Congestion                           |                         3                                                |             
      Cytologic Alterations                |                                                                          |             
      Cytologic Alterations, Multiple      |                                                                   X      |             
      Fibrosis, Focal                      |                               2                    1        1            |             
      Hepatodiaphragmatic Nodule           |                               X                    X        X            |             
      Hyperplasia, Nodular                 |                                  2                                       |             
      Inflammation, Chronic                |                               1  2           1                    2      |             
      Necrosis, Focal                      |                                                                          |             
      Necrosis, Multifocal                 |       3                                2                                 |             
      Vacuolization Cytoplasmic            |                                                    3                     |             
      Bile Duct, Hyperplasia               |                                                                          |             
      Centrilobular, Fibrosis, Multifocal  |       3                                                                  |             
      Centrilobular, Necrosis              |    2                                                                     |             
      Centrilobular, Vacuolization         |                                                                          |             
          Cytoplasmic                      |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               | +     +           +                                                      |             
      Hemorrhage                           |                   2                                                      |             
      Inflammation, Chronic                |       3                                                                  |             
      Fat, Necrosis                        | 2                                                                        |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +  +  +  +     +  +  +  +           +  +  +  +  +  +  +               |             
      Inflammation, Acute                  |                                                                          |             
      Acinus, Atrophy, Focal               |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +  +  +  +     +  +  +  +           +  +  +  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Stomach                                 |    +  +  +  +     +  +  +  +           +  +  +  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +  +  +  +     +  +  +  +           +  +  +  +  +  +  +               |             
      Edema                                |                                                       2                  |             
      Inflammation, Acute                  |                                                    1                     |             
      Inflammation, Chronic                |                                                                          |             
      Epithelium, Hyperplasia              |                                                    2                     |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +  +  +  +     +  +  +  +           +  +  +  +  +  +  +               |             
      Inflammation, Acute                  |                                                    1                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  15                                                               
NTP Experiment-Test: 05041-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 11:52:17  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 4| 0| 0| 7| 0| 0| 0| 0| 7| 7| 7| 7| 0| 7| 6| 6| 1| 0| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 9| 0| 0| 0| 3| 1| 1| 0| 0| 3| 3| 3| 0| 1| 3| 9| 8| 6| 0| 3| 3| 3| 3| 3|             
                                           | 1| 0| 1| 5| 2| 1| 3| 0| 9| 9| 1| 1| 1| 5| 2| 1| 1| 4| 9| 2| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    50 MG/KG                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
     LOW FEM                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |    +  +  +  +     +  +  +  +           +  +  +  +  +  +  +               |             
      Cardiomyopathy                       |       2                                         2  1                     |             
      Foreign Body                         |                                                                          |             
      Atrium, Thrombosis                   |                                                                          |             
      Epicardium, Inflammation, Chronic    |                         2              2                                 |             
      Epicardium, Necrosis                 |          2                                               1               |             
      Pericardium, Inflammation, Acute     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +     +  +  +  +           +  +  +  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +     +  +  +  +           +  +  +  +  +  +  +               |             
      Congestion                           |                                                       3                  |             
      Hypertrophy, Focal                   |                                              4                           |             
      Metaplasia, Osseous                  |                                                                          |             
      Necrosis, Focal                      |                                        2                                 |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |    +  +  +  +     +  +  +  +           +  +  +  +  +  +  +               |             
      Hyperplasia                          |    2                                         2  1                        |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +  +  +  +     +  +  +  +           +  +  +  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    M  +  M  M     +  +  +  +           +  +  +  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
      Pars Distalis, Angiectasis           |    2                                                              2  2  2|             
      Pars Distalis, Hyperplasia           |       3                                                                  |             
      Pars Distalis, Pigmentation          |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |    +  +  +  +     +  +  +  +  +        +  +  +  +  +  +  +               |             
      C-Cell, Hyperplasia                  |                                              1                           |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |    +  M  M  M     M  M  M  M           +  M  M  +  +  M  M           +   |             
      Dilatation                           |                                                                          |             
      Inflammation, Acute                  |                                                                      2   |             
                                            __________________________________________________________________________|             
   Ovary                                   |    +  +  +  +     +  +  +  +           +  +  +  +  +  +  +               |             
      Cyst                                 |                                                    3                     |             
      Hemorrhage                           |       3                                                                  |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +     +  +  +  +  +        +  +  +  +  +  +  +               |             
      Hemorrhage                           |                               3                                          |             
      Endometrium, Hyperplasia, Cystic     | 2                                                                        |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +  +  +  +     +  +  +  +           +  +  +  +  +  +  +               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  16                                                               
NTP Experiment-Test: 05041-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 11:52:17  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 4| 0| 0| 7| 0| 0| 0| 0| 7| 7| 7| 7| 0| 7| 6| 6| 1| 0| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 9| 0| 0| 0| 3| 1| 1| 0| 0| 3| 3| 3| 0| 1| 3| 9| 8| 6| 0| 3| 3| 3| 3| 3|             
                                           | 1| 0| 1| 5| 2| 1| 3| 0| 9| 9| 1| 1| 1| 5| 2| 1| 1| 4| 9| 2| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    50 MG/KG                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
     LOW FEM                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hyperplasia, Reticulum Cell          |                                              4                           |             
      Hypoplasia                           |                                                       2                  |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +  +  +  +     +  +  +  +           +  +  +  +  +  +  +               |             
      Mediastinal, Giant Cell, Multiple    |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |    +  +  +  +     +  +  +  M           +  +  +  +  +  +  +               |             
      Hemorrhage                           |          2           3                                                   |             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |    +  +  +  +     M  +  +  +           +  +  +  +  +  M  +               |             
      Edema                                |                                                                          |             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  |    +  +  +  +     M  +  +  +           +  +  +  +  +  +  +               |             
      Congestion                           |                                                                          |             
      Hematopoietic Cell Proliferation     |    2  2                                                                  |             
      Infarct                              |                                                                          |             
      Pigmentation                         |                                                    1                     |             
                                            __________________________________________________________________________|             
   Thymus                                  |    +  +  +  +     +  +  +  +           +  +  +  +  +  +  +               |             
      Necrosis                             |                            4              3                              |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  M  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                2                                                         |             
      Hyperplasia                          |                                        2                                 |             
                                            __________________________________________________________________________|             
   Skin                                    |    +  +  +  +     +  +  +  +           +  +  +  +  +  +  +               |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +  +  +  +     +  +  +  +           +  +  +  +  +  +  +               |             
      Cranium, Hemorrhage                  |                      2                                                   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +  +  +  +     +  +  +  +           +  +  +  +  +  +  +               |             
      Hemorrhage                           |                   2  4                                                   |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  |    +  +  +  +     +  +  +  +           +  +  +  +  +  +  +               |             
      Necrosis                             |                                           2                              |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +     +  +  +  +           +  +  +  +  +  +  +  +            |             
      Congestion                           |          2        3        2                             3               |             
      Edema                                |                                                                          |             
      Foreign Body                         |                   2     3  4                                             |             
      Hemorrhage                           |                      1  4                                                |             
      Hyperplasia, Adenomatous             |                                                             1            |             
      Infiltration Cellular, Histiocyte    |                                              1                           |             
      Inflammation, Acute                  |                            3                                             |             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  17                                                               
NTP Experiment-Test: 05041-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 11:52:17  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 4| 0| 0| 7| 0| 0| 0| 0| 7| 7| 7| 7| 0| 7| 6| 6| 1| 0| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 9| 0| 0| 0| 3| 1| 1| 0| 0| 3| 3| 3| 0| 1| 3| 9| 8| 6| 0| 3| 3| 3| 3| 3|             
                                           | 1| 0| 1| 5| 2| 1| 3| 0| 9| 9| 1| 1| 1| 5| 2| 1| 1| 4| 9| 2| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    50 MG/KG                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
     LOW FEM                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Inflammation, Granulomatous          |                                                                          |             
      Pigmentation                         |                      1                                                   |             
      Pleura, Foreign Body                 |                                                          2               |             
      Pleura, Inflammation, Acute          |                                                                          |             
      Pleura, Necrosis                     |          2  2                             3              2               |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  M  M  +  M  M  M  M  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +|             
      Foreign Body                         |                                                                          |             
      Sinus, Foreign Body                  |                                                                          |             
      Sinus, Inflammation, Acute           |                                                                          |             
      Turbinate, Inflammation, Chronic     |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 |    +  +  +  +     +  +  +  +           +  +  +  +  +  +  +               |             
      Necrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                +     +                                            +      |             
      Lens Capsule, Cataract               |                2                                                  3      |             
      Retina, Atrophy                      |                3                                                  3      |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                   +                                                      |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hemorrhage                           |                                                       2                  |             
      Nephropathy                          |                1                    1              2           1         |             
      Pigmentation                         |                                                                          |             
      Pelvis, Mineralization               |                                                                          |             
      Renal Tubule, Atrophy                |                                                       2                  |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    +  +  +  +     +  +  M  +           +  M  +  +  +  +  +               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  18                                                               
NTP Experiment-Test: 05041-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 11:52:17  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 6| 5| 7| 7| 6| 6| 5| 4| 7| 7| 7| 6| 7| 7| 7| 6| 0| 7| 7| 7| 6| 6|             
                             DAY ON TEST   | 1| 3| 3| 8| 9| 2| 3| 7| 0| 4| 7| 3| 3| 3| 2| 2| 3| 3| 0| 1| 3| 3| 3| 9| 0|             
                                           | 7| 1| 1| 9| 9| 3| 2| 7| 6| 1| 1| 2| 2| 2| 0| 3| 2| 2| 3| 1| 2| 2| 2| 5| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    50 MG/KG                               | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
     LOW FEM                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +        +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +        +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +        +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  M  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +        +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +        +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  M  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +        +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +        +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +        +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  M  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +        +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  M  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                              X                           |             
      Basophilic Focus, Multiple           | X           X     X     X        X  X           X     X     X  X         |             
      Congestion                           |                               2                                          |             
      Cytologic Alterations                |                                     X                                    |             
      Cytologic Alterations, Multiple      |                                                                          |             
      Fibrosis, Focal                      |                1  1  2           1        1                       2     1|             
      Hepatodiaphragmatic Nodule           |                X     X           X        X                       X     X|             
      Hyperplasia, Nodular                 |                2                                   2                     |             
      Inflammation, Chronic                |                1  1              1  1           1           1  2         |             
      Necrosis, Focal                      |                               1                                          |             
      Necrosis, Multifocal                 |                                                                      4   |             
      Vacuolization Cytoplasmic            |                                                                         2|             
      Bile Duct, Hyperplasia               |          1        2              1                          1            |             
      Centrilobular, Fibrosis, Multifocal  |                                                                          |             
      Centrilobular, Necrosis              |                      2                                                   |             
      Centrilobular, Vacuolization         |                                                                          |             
          Cytoplasmic                      |                                           2                              |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                +         |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Fat, Necrosis                        |                                                                2         |             
                                            __________________________________________________________________________|             
   Pancreas                                | +        +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  A  +  +  +  +  +|             
      Inflammation, Acute                  |                                                                          |             
      Acinus, Atrophy, Focal               |                      2           3        1  1  1                        |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +        +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +        +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +        +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  M  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Inflammation, Acute                  |                                                                         2|             
      Inflammation, Chronic                |                                                                          |             
      Epithelium, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +        +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  19                                                               
NTP Experiment-Test: 05041-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 11:52:17  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 6| 5| 7| 7| 6| 6| 5| 4| 7| 7| 7| 6| 7| 7| 7| 6| 0| 7| 7| 7| 6| 6|             
                             DAY ON TEST   | 1| 3| 3| 8| 9| 2| 3| 7| 0| 4| 7| 3| 3| 3| 2| 2| 3| 3| 0| 1| 3| 3| 3| 9| 0|             
                                           | 7| 1| 1| 9| 9| 3| 2| 7| 6| 1| 1| 2| 2| 2| 0| 3| 2| 2| 3| 1| 2| 2| 2| 5| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    50 MG/KG                               | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
     LOW FEM                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +        +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1              1  1  1  1                 1  1              1  2  1      |             
      Foreign Body                         |                                                                          |             
      Atrium, Thrombosis                   |                      2                                                   |             
      Epicardium, Inflammation, Chronic    |                                                                          |             
      Epicardium, Necrosis                 |                                                                          |             
      Pericardium, Inflammation, Acute     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +        +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +        +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  M  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hypertrophy, Focal                   |                                                                          |             
      Metaplasia, Osseous                  |                                                       2                  |             
      Necrosis, Focal                      |          2  2                                                            |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +        +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  M  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +        +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +        +  M  +  +  +  +  +  +  +  +     +  +  +  +  +  M  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |    +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                                  2                 2  2              3   |             
      Pars Distalis, Hyperplasia           |                         2                                                |             
      Pars Distalis, Pigmentation          |          1                                                               |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +        +  M  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |                                  2                             1  1      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +     M  +  +  +  +  +  +  M  +  +     M  +  +  +  M  M  +  M  +  +  M|             
      Dilatation                           |    2                                                                     |             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +        +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |             2  2              3                                          |             
      Hemorrhage                           |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Endometrium, Hyperplasia, Cystic     |                2                                                         |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +        +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  20                                                               
NTP Experiment-Test: 05041-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 11:52:17  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 6| 5| 7| 7| 6| 6| 5| 4| 7| 7| 7| 6| 7| 7| 7| 6| 0| 7| 7| 7| 6| 6|             
                             DAY ON TEST   | 1| 3| 3| 8| 9| 2| 3| 7| 0| 4| 7| 3| 3| 3| 2| 2| 3| 3| 0| 1| 3| 3| 3| 9| 0|             
                                           | 7| 1| 1| 9| 9| 3| 2| 7| 6| 1| 1| 2| 2| 2| 0| 3| 2| 2| 3| 1| 2| 2| 2| 5| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    50 MG/KG                               | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
     LOW FEM                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hyperplasia, Reticulum Cell          |                                  4                                       |             
      Hypoplasia                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +        +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Mediastinal, Giant Cell, Multiple    |                                  2                                       |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +        +  M  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +        +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                             2            |             
      Pigmentation                         |                               2                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Infarct                              |                                                                   2      |             
      Pigmentation                         |                            2        1     2     1              1         |             
                                            __________________________________________________________________________|             
   Thymus                                  | +        +  +  +  M  +  M  +  +  +  +     M  +  +  +  +  +  +  +  M  +  +|             
      Necrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +|             
      Dilatation                           |                                                                2         |             
      Hyperplasia                          |                                                 2                        |             
                                            __________________________________________________________________________|             
   Skin                                    | +        +  +  +  +  +  +  +  +  +  +     +  +  +  +  M  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +        +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Cranium, Hemorrhage                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +        +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +        +  M  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Edema                                |                      2                                                   |             
      Foreign Body                         |                            3  3                       2                  |             
      Hemorrhage                           |                            2                                             |             
      Hyperplasia, Adenomatous             |                                     1                                    |             
      Infiltration Cellular, Histiocyte    | 1                 1              1  1     1                 1        1   |             
      Inflammation, Acute                  |                            3                                             |             
      Inflammation, Chronic                |                                                       2                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  21                                                               
NTP Experiment-Test: 05041-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 11:52:17  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 6| 5| 7| 7| 6| 6| 5| 4| 7| 7| 7| 6| 7| 7| 7| 6| 0| 7| 7| 7| 6| 6|             
                             DAY ON TEST   | 1| 3| 3| 8| 9| 2| 3| 7| 0| 4| 7| 3| 3| 3| 2| 2| 3| 3| 0| 1| 3| 3| 3| 9| 0|             
                                           | 7| 1| 1| 9| 9| 3| 2| 7| 6| 1| 1| 2| 2| 2| 0| 3| 2| 2| 3| 1| 2| 2| 2| 5| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    50 MG/KG                               | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
     LOW FEM                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Inflammation, Granulomatous          |                               4                                          |             
      Pigmentation                         |                                                                          |             
      Pleura, Foreign Body                 |                                                                          |             
      Pleura, Inflammation, Acute          |                                                                          |             
      Pleura, Necrosis                     |                                                          2               |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Foreign Body                         |                            2                                             |             
      Sinus, Foreign Body                  | 2                             3                                          |             
      Sinus, Inflammation, Acute           | 2           1           2  2  2           2                             2|             
      Turbinate, Inflammation, Chronic     |                                                                      2   |             
                                            __________________________________________________________________________|             
   Trachea                                 | +        +  M  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Necrosis                             | 3                                                                        |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                +           +  +                                          |             
      Lens Capsule, Cataract               |                2                                                         |             
      Retina, Atrophy                      |                2                                                         |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                               2                                          |             
      Hemorrhage                           |                                                                          |             
      Nephropathy                          |    1           1  1                 1     2                    1  1      |             
      Pigmentation                         |                                  1                                   2   |             
      Pelvis, Mineralization               |                                                                      1   |             
      Renal Tubule, Atrophy                |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +     +  M  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  22                                                               
NTP Experiment-Test: 05041-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 11:52:17  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 1| 7| 6| 7| 7| 0|                                            |            |
                             DAY ON TEST   | 2| 3| 3| 2| 8| 3| 4| 3| 3| 0|                                            |            |
                                           | 3| 2| 2| 3| 7| 2| 2| 2| 2| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      A     |
    50 MG/KG                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |      L     |
     LOW FEM                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +     +  +  +     +  +  +  +                                             |  45        |
      Hemorrhage                           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +     +  +  +     +  +  +  +                                             |  45        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +     +  +  +     +  +  +  M                                             |  35        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +     +  +  +     +  +  +  +                                             |  44        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +     +  +  +     +  +  +  M                                             |  35        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +     +  +  +     +  +  +  +                                             |  45        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +     +  +  +     +  +  +  +                                             |  44        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +     +  +  +     +  +  +  M                                             |  35        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +     +  +  +     +  +  +  M                                             |  35        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +     +  +  +  +                                             |  52        |
      Basophilic Focus                     |    X                                                                     |      3     |
      Basophilic Focus, Multiple           |       X  X                                                               |     16     |
      Congestion                           |                                                                          |      2  2.5|
      Cytologic Alterations                |                                                                          |      1     |
      Cytologic Alterations, Multiple      |                                                                          |      1     |
      Fibrosis, Focal                      |       2              1                                                   |     12  1.3|
      Hepatodiaphragmatic Nodule           |       X              X  X                                                |     12     |
      Hyperplasia, Nodular                 |                                                                          |      3  2.0|
      Inflammation, Chronic                | 1     2           2  2                                                   |     15  1.4|
      Necrosis, Focal                      |                                                                          |      1  1.0|
      Necrosis, Multifocal                 |                                                                          |      3  3.0|
      Vacuolization Cytoplasmic            |                   2                                                      |      3  2.3|
      Bile Duct, Hyperplasia               |    1     1                                                               |      6  1.2|
      Centrilobular, Fibrosis, Multifocal  |                                                                          |      1  3.0|
      Centrilobular, Necrosis              |             2                                                            |      3  2.0|
      Centrilobular, Vacuolization         |                                                                          |            |
          Cytoplasmic                      |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |          +  +                                                            |   6        |
      Hemorrhage                           |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                                                          |      1  3.0|
      Fat, Necrosis                        |          2  2                                                            |      4  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +     +  +  +     +  +  +  +                                             |  44        |
      Inflammation, Acute                  |             2                                                            |      1  2.0|
      Acinus, Atrophy, Focal               |                                                                          |      5  1.6|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +     +  +  +     +  +  +  +                                             |  45        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +     +  +  +     +  +  +  +                                             |  45        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +     +  +  +     +  +  +  +                                             |  44        |
      Edema                                |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  23                                                               
NTP Experiment-Test: 05041-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 11:52:17  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 1| 7| 6| 7| 7| 0|                                            |            |
                             DAY ON TEST   | 2| 3| 3| 2| 8| 3| 4| 3| 3| 0|                                            |            |
                                           | 3| 2| 2| 3| 7| 2| 2| 2| 2| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      A     |
    50 MG/KG                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |      L     |
     LOW FEM                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Acute                  |                                                                          |      2  1.5|
      Inflammation, Chronic                |                   2                                                      |      1  2.0|
      Epithelium, Hyperplasia              |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +     +  +  +     +  +  +  +                                             |  45        |
      Inflammation, Acute                  |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +     +  +  +     +  +  +  +                                             |  45        |
      Cardiomyopathy                       | 2        2        1  1  1                                                |     18  1.3|
      Foreign Body                         |             3                                                            |      1  3.0|
      Atrium, Thrombosis                   |                                                                          |      1  2.0|
      Epicardium, Inflammation, Chronic    |                                                                          |      2  2.0|
      Epicardium, Necrosis                 |                                                                          |      2  1.5|
      Pericardium, Inflammation, Acute     |             4                                                            |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +     +  +  +     +  +  +  +                                             |  46        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +     +  +  +     +  +  +  +                                             |  45        |
      Congestion                           |                                                                          |      1  3.0|
      Hypertrophy, Focal                   |                                                                          |      1  4.0|
      Metaplasia, Osseous                  |                                                                          |      1  2.0|
      Necrosis, Focal                      | 3        2                                                               |      5  2.2|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |       +  +  +     +  +  +  +                                             |  43        |
      Hyperplasia                          |                                                                          |      3  1.7|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +     +  +  +     +  +  +  +                                             |  44        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +     +  M  +     +  +  +  +                                             |  38        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +     +  +  +  +  +  +  +  +                                             |  55        |
      Pars Distalis, Angiectasis           |                4                                                         |      9  2.3|
      Pars Distalis, Hyperplasia           |                                                                          |      2  2.5|
      Pars Distalis, Pigmentation          |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +     +  +  +     +  +  +  +                                             |  45        |
      C-Cell, Hyperplasia                  |                                                                          |      4  1.3|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +     M  +  +     +  +  +  M                                             |  27        |
      Dilatation                           |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  24                                                               
NTP Experiment-Test: 05041-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 11:52:17  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 1| 7| 6| 7| 7| 0|                                            |            |
                             DAY ON TEST   | 2| 3| 3| 2| 8| 3| 4| 3| 3| 0|                                            |            |
                                           | 3| 2| 2| 3| 7| 2| 2| 2| 2| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      A     |
    50 MG/KG                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |      L     |
     LOW FEM                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Acute                  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   |       +  +  +     +  +  +  +                                             |  44        |
      Cyst                                 |                                                                          |      4  2.5|
      Hemorrhage                           |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +     +  +  +     +  +  +  +                                             |  48        |
      Hemorrhage                           |                                                                          |      1  3.0|
      Endometrium, Hyperplasia, Cystic     |       2                                                                  |      3  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +     +  +  +     +  +  +  +                                             |  45        |
      Hyperplasia, Reticulum Cell          |                                                                          |      2  4.0|
      Hypoplasia                           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +     +  +  +     +  +  +  +                                             |  45        |
      Mediastinal, Giant Cell, Multiple    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +     +  +  +     +  +  +  +                                             |  43        |
      Hemorrhage                           |                                                                          |      2  2.5|
      Hyperplasia, Lymphoid                |                      2                                                   |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +     +  +  +     +  +  +  +                                             |  43        |
      Edema                                |                      2                                                   |      2  2.0|
      Pigmentation                         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +     +  +  +  +  +  +  +  +                                             |  46        |
      Congestion                           |                2                                                         |      1  2.0|
      Hematopoietic Cell Proliferation     |          1                                                               |      3  1.7|
      Infarct                              |                                                                          |      1  2.0|
      Pigmentation                         |             2                                                            |      7  1.4|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +     +  +  +     +  +  +  +                                             |  41        |
      Necrosis                             |                                                                          |      2  3.5|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  55        |
      Dilatation                           |    1  2                                                                  |      4  1.8|
      Hyperplasia                          |                         1                                                |      3  1.7|
                                            __________________________________________________________________________|____________|
   Skin                                    | +     +  +  +     +  +  +  +                                             |  44        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +     +  +  +     +  +  +  +                                             |  45        |
      Cranium, Hemorrhage                  |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  25                                                               
NTP Experiment-Test: 05041-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 11:52:17  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 1| 7| 6| 7| 7| 0|                                            |            |
                             DAY ON TEST   | 2| 3| 3| 2| 8| 3| 4| 3| 3| 0|                                            |            |
                                           | 3| 2| 2| 3| 7| 2| 2| 2| 2| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      A     |
    50 MG/KG                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |      L     |
     LOW FEM                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +     +  +  +     +  +  +  +                                             |  45        |
      Hemorrhage                           |                            2                                             |      3  2.7|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +     +  +  +     +  +  +  +                                             |  44        |
      Necrosis                             |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lung                                    | +     +  +  +  +  +  +  +  +                                             |  49        |
      Congestion                           |                            2                                             |      5  2.4|
      Edema                                |                                                                          |      1  2.0|
      Foreign Body                         |                            2                                             |      7  2.7|
      Hemorrhage                           |                                                                          |      3  2.3|
      Hyperplasia, Adenomatous             |       1        2                                                         |      4  1.3|
      Infiltration Cellular, Histiocyte    |       1  1     1     1  1                                                |     13  1.0|
      Inflammation, Acute                  |                            3                                             |      3  3.0|
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Inflammation, Granulomatous          |                                                                          |      1  4.0|
      Pigmentation                         |                                                                          |      1  1.0|
      Pleura, Foreign Body                 |                                                                          |      1  2.0|
      Pleura, Inflammation, Acute          |             3                                                            |      1  3.0|
      Pleura, Necrosis                     |                                                                          |      5  2.2|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  M                                             |  50        |
      Foreign Body                         |                                                                          |      1  2.0|
      Sinus, Foreign Body                  |                                                                          |      2  2.5|
      Sinus, Inflammation, Acute           |                                                                          |      7  1.9|
      Turbinate, Inflammation, Chronic     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +     +  +  +     +  +  +  +                                             |  44        |
      Necrosis                             |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |    +     +                                                               |   8        |
      Lens Capsule, Cataract               |    3                                                                     |      4  2.5|
      Retina, Atrophy                      |    3     2                                                               |      5  2.6|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +     +  +  +  +  +  +                                             |  59        |
      Congestion                           |                                                                          |      1  2.0|
      Hemorrhage                           |                                                                          |      1  2.0|
      Nephropathy                          |    1  1           2  1                                                   |     15  1.2|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  26                                                               
NTP Experiment-Test: 05041-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 11:52:17  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 1| 7| 6| 7| 7| 0|                                            |            |
                             DAY ON TEST   | 2| 3| 3| 2| 8| 3| 4| 3| 3| 0|                                            |            |
                                           | 3| 2| 2| 3| 7| 2| 2| 2| 2| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      A     |
    50 MG/KG                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |      L     |
     LOW FEM                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Pigmentation                         |                                                                          |      2  1.5|
      Pelvis, Mineralization               | 2                       1                                                |      3  1.3|
      Renal Tubule, Atrophy                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |       +  +  +        +  +  +                                             |  41        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  27                                                               
NTP Experiment-Test: 05041-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 11:52:17  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 7| 7| 7| 7| 7| 5| 2| 7| 7| 7| 7| 0| 7| 7| 6| 3| 1| 7| 1| 1| 3| 3|             
                             DAY ON TEST   | 3| 1| 0| 3| 0| 3| 2| 1| 6| 2| 3| 3| 3| 3| 0| 3| 2| 2| 5| 9| 3| 7| 7| 3| 6|             
                                           | 1| 9| 6| 2| 5| 2| 0| 1| 3| 5| 2| 2| 2| 2| 9| 2| 0| 5| 3| 8| 2| 6| 0| 7| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    100MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     HIGHFEM                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Adventitia, Fibrosis                 |                                                                          |             
      Muscularis, Regeneration             |                                           2                              |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus, Multiple           |          X  X  X  X           X  X  X  X     X  X           X            |             
      Congestion                           |                                                          2               |             
      Cytologic Alterations                |          X     X     X                       X  X           X            |             
      Fibrosis, Focal                      |    1     2              2                       2                       1|             
      Hepatodiaphragmatic Nodule           |          X           X  X     X                    X                    X|             
      Hyperplasia, Nodular                 |                                                                          |             
      Inflammation, Acute                  |                   2                                                      |             
      Inflammation, Chronic                | 1           1                    2  2        2              2            |             
      Necrosis, Multifocal                 |                         2                                                |             
      Vacuolization Cytoplasmic            |       4  2                                                               |             
      Bile Duct, Hyperplasia               |                                                    2        1            |             
      Centrilobular, Congestion            |                                                                2         |             
      Centrilobular, Vacuolization         |                                                                          |             
          Cytoplasmic                      |    3                                                                     |             
      Hepatocyte, Inclusion Body           |                                                                          |             
          Intranuclear                     |                                                                         2|             
                                            __________________________________________________________________________|             
   Mesentery                               |                                     +                    +               |             
      Hemorrhage                           |                                                          3               |             
      Inflammation, Chronic                |                                                          2               |             
      Fat, Necrosis                        |                                     2                                    |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hemorrhage                           |                            2                                             |             
      Inflammation, Chronic                |                                                          1               |             
      Acinus, Atrophy, Focal               |    1        1                                   2                        |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Erosion, Acute                       |                                                                          |             
      Hyperplasia, Focal                   |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  28                                                               
NTP Experiment-Test: 05041-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 11:52:17  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 7| 7| 7| 7| 7| 5| 2| 7| 7| 7| 7| 0| 7| 7| 6| 3| 1| 7| 1| 1| 3| 3|             
                             DAY ON TEST   | 3| 1| 0| 3| 0| 3| 2| 1| 6| 2| 3| 3| 3| 3| 0| 3| 2| 2| 5| 9| 3| 7| 7| 3| 6|             
                                           | 1| 9| 6| 2| 5| 2| 0| 1| 3| 5| 2| 2| 2| 2| 9| 2| 0| 5| 3| 8| 2| 6| 0| 7| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    100MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     HIGHFEM                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Epithelium, Cyst                     |                                                       2                  |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1              2                 1  2  1     1  1           1            |             
      Atrium, Thrombosis                   |                                                                          |             
      Coronary Artery, Inflammation,       |                                                                          |             
          Chronic                          |                                                                          |             
      Epicardium, Foreign Body             |                                                          2     2         |             
      Epicardium, Inflammation, Acute      |                                                                          |             
      Epicardium, Inflammation, Chronic    |                                                                          |             
          Active                           |                               2                          4     4         |             
      Epicardium, Necrosis                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hyperplasia                          |                                                                          |             
      Hypertrophy                          |                                     3                                    |             
      Necrosis, Focal                      |                                                                          |             
      Vacuolization Cytoplasmic, Focal     |                      3                                                   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  M  +  +  +  +  +     +  +  M  +  +  +  +  M  M  +|             
      Hyperplasia                          |    1                             1              1           1            |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  M  +  M  +  +  M  +  +  M  +  +  +  M  +  M  +  +  M  +  +  +  M  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Pars Distalis, Angiectasis           |                2                       2     2                           |             
      Pars Distalis, Cyst                  |                         2                                                |             
      Pars Distalis, Degeneration, Focal   |                                                                          |             
      Pars Distalis, Hyperplasia           |                                        2                                 |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |                2                       1                                 |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  29                                                               
NTP Experiment-Test: 05041-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 11:52:17  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 7| 7| 7| 7| 7| 5| 2| 7| 7| 7| 7| 0| 7| 7| 6| 3| 1| 7| 1| 1| 3| 3|             
                             DAY ON TEST   | 3| 1| 0| 3| 0| 3| 2| 1| 6| 2| 3| 3| 3| 3| 0| 3| 2| 2| 5| 9| 3| 7| 7| 3| 6|             
                                           | 1| 9| 6| 2| 5| 2| 0| 1| 3| 5| 2| 2| 2| 2| 9| 2| 0| 5| 3| 8| 2| 6| 0| 7| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    100MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     HIGHFEM                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Atrophy                              |          2  1                                                            |             
      Congestion                           |                                                                          |             
      Cyst                                 |          2                                                               |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hemorrhage                           |                                                                          |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Hyperplasia, Reticulum Cell          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mediastinal, Foreign Body            |                                                          2        2      |             
      Mediastinal, Hemorrhage              |                                                 1                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Congestion                           |                                                                          |             
      Cyst                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                            3                             3     2         |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis, Focal                      |                                                                          |             
      Hematopoietic Cell Proliferation     |                   2                                                      |             
      Inflammation, Chronic                |                                                                          |             
      Pigmentation                         | 2                       2                    2  1        1               |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  M  +  +  M  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Hemorrhage                           |                                                                          |             
      Necrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                                                          |             
      Hyperplasia                          |                                  1                                       |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Acute                           |                   2                                                      |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                          +               |             
      Inflammation, Chronic Active         |                                                          3               |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  30                                                               
NTP Experiment-Test: 05041-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 11:52:17  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 7| 7| 7| 7| 7| 5| 2| 7| 7| 7| 7| 0| 7| 7| 6| 3| 1| 7| 1| 1| 3| 3|             
                             DAY ON TEST   | 3| 1| 0| 3| 0| 3| 2| 1| 6| 2| 3| 3| 3| 3| 0| 3| 2| 2| 5| 9| 3| 7| 7| 3| 6|             
                                           | 1| 9| 6| 2| 5| 2| 0| 1| 3| 5| 2| 2| 2| 2| 9| 2| 0| 5| 3| 8| 2| 6| 0| 7| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    100MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     HIGHFEM                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Thrombosis, Multifocal               |       2                                                                  |             
      Meninges, Infiltration Cellular,     |                                                                          |             
           Lymphocyte                      |                                                                          |             
      Pons, Vacuolization Cytoplasmic      |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           | 2                       2                             2                  |             
      Edema                                |                                                                          |             
      Fibrosis, Focal                      |                                                                          |             
      Foreign Body                         |                         2     2                 2     2                  |             
      Hemorrhage                           |                                           3                              |             
      Hyperplasia, Adenomatous             |                2                                               1         |             
      Infiltration Cellular, Histiocyte    |          2  1  1     1           1  1  1     2     1                    1|             
      Inflammation, Acute                  |                                                       3                  |             
      Inflammation, Chronic                |                                                                          |             
      Pigmentation                         |                                                                   1      |             
      Bronchiole, Foreign Body             |                                                                          |             
      Bronchiole, Inflammation, Acute      |                                                 3                        |             
      Bronchiole, Inflammation, Subacute   |                               3                                          |             
      Mediastinum, Foreign Body            |                                                                   2      |             
      Mediastinum, Hemorrhage              |                                                                   4      |             
      Mediastinum, Inflammation, Chronic   |                                                                          |             
          Active                           |                                                          3     4         |             
      Mediastinum, Necrosis                |                                                                          |             
      Pleura, Fibrosis                     |                                                                   2      |             
      Pleura, Inflammation, Chronic Active |                                                          2     2         |             
      Pleura, Necrosis                     |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Sinus, Foreign Body                  |                                                    2                     |             
      Sinus, Fungus                        | 2                                                                        |             
      Sinus, Hemorrhage                    |                                                                          |             
      Sinus, Inflammation, Acute           | 2           2                                   3  2                     |             
      Turbinate, Inflammation, Subacute    |                               2     2                                    |             
      Turbinate, Necrosis                  |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Inflammation, Chronic                |                               1                                          |             
      Necrosis                             |                         4                             3                  |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  31                                                               
NTP Experiment-Test: 05041-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 11:52:17  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 7| 7| 7| 7| 7| 5| 2| 7| 7| 7| 7| 0| 7| 7| 6| 3| 1| 7| 1| 1| 3| 3|             
                             DAY ON TEST   | 3| 1| 0| 3| 0| 3| 2| 1| 6| 2| 3| 3| 3| 3| 0| 3| 2| 2| 5| 9| 3| 7| 7| 3| 6|             
                                           | 1| 9| 6| 2| 5| 2| 0| 1| 3| 5| 2| 2| 2| 2| 9| 2| 0| 5| 3| 8| 2| 6| 0| 7| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    100MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     HIGHFEM                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                +                    +                                    |             
      Lens Capsule, Cataract               |                2                    2                                    |             
      Retina, Atrophy                      |                3                    2                                    |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Nephropathy                          |          1              1        1              1           1            |             
      Pigmentation                         |       3                                                                  |             
      Pelvis, Mineralization               |                      1                             1                     |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  32                                                               
NTP Experiment-Test: 05041-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 11:52:17  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 1| 0| 0| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 5| 2| 7| 7| 6| 6| 2|             
                             DAY ON TEST   | 3| 7| 1| 0| 0| 3| 3| 3| 3| 0| 3| 3| 2| 2| 3| 3| 3| 7| 8| 8| 3| 3| 6| 0| 0|             
                                           | 2| 4| 1| 9| 5| 2| 2| 2| 2| 3| 2| 2| 6| 6| 2| 2| 2| 8| 6| 3| 2| 2| 3| 6| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    100MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
     HIGHFEM                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                         4|             
      Adventitia, Fibrosis                 |                                                                         4|             
      Muscularis, Regeneration             |             2                                                            |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  M  M  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  M  M  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  A  +  M  A  +  +  +  +  A  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  A  +  M  A  +  +  +  +  A  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  A  M  M  A  +  +  +  +  A  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  A  M  M  A  +  +  +  +  A  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus, Multiple           | X                    X  X                 X           X     X  X         |             
      Congestion                           |       2                                                           2      |             
      Cytologic Alterations                |                                                                          |             
      Fibrosis, Focal                      |                         2     2  2              2        1               |             
      Hepatodiaphragmatic Nodule           |                         X     X  X  X     X     X        X               |             
      Hyperplasia, Nodular                 |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |    1                                      2     2  1        2  2         |             
      Necrosis, Multifocal                 |                                                                          |             
      Vacuolization Cytoplasmic            |                                     2                                3   |             
      Bile Duct, Hyperplasia               | 1  1              2              1  2  2  2                              |             
      Centrilobular, Congestion            |                                                                          |             
      Centrilobular, Vacuolization         |                                                                          |             
          Cytoplasmic                      |                                                                          |             
      Hepatocyte, Inclusion Body           |                                                                          |             
          Intranuclear                     |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Fat, Necrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 | 1                                                                        |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Acinus, Atrophy, Focal               |                                                             1            |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion, Acute                       |                                                                      2   |             
      Hyperplasia, Focal                   |                      2                                                   |             
      Inflammation, Chronic                |                            2                                             |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  33                                                               
NTP Experiment-Test: 05041-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 11:52:17  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 1| 0| 0| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 5| 2| 7| 7| 6| 6| 2|             
                             DAY ON TEST   | 3| 7| 1| 0| 0| 3| 3| 3| 3| 0| 3| 3| 2| 2| 3| 3| 3| 7| 8| 8| 3| 3| 6| 0| 0|             
                                           | 2| 4| 1| 9| 5| 2| 2| 2| 2| 3| 2| 2| 6| 6| 2| 2| 2| 8| 6| 3| 2| 2| 3| 6| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    100MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
     HIGHFEM                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  A  +  +     +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Epithelium, Cyst                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1  1                 1        1  2                 1        2     1      |             
      Atrium, Thrombosis                   |                                                                          |             
      Coronary Artery, Inflammation,       |                                                                          |             
          Chronic                          |                                                                          |             
      Epicardium, Foreign Body             |                                                                          |             
      Epicardium, Inflammation, Acute      |             2                                                            |             
      Epicardium, Inflammation, Chronic    |                                                                          |             
          Active                           |                                                                          |             
      Epicardium, Necrosis                 |       3  2                                                               |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                   2      |             
      Hyperplasia                          |                      2                                                   |             
      Hypertrophy                          |                                                                          |             
      Necrosis, Focal                      |                                                 2                        |             
      Vacuolization Cytoplasmic, Focal     |                2                 2                    2                  |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                1                    1  2  1                 1            |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                   2      |             
      Pars Distalis, Angiectasis           |                                           2                    2         |             
      Pars Distalis, Cyst                  |                                                                      2   |             
      Pars Distalis, Degeneration, Focal   |                                           1                              |             
      Pars Distalis, Hyperplasia           |                   1           3              2              1            |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  | 1                             1     1                                    |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  M  M  M|             
      Dilatation                           |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  34                                                               
NTP Experiment-Test: 05041-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 11:52:17  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 1| 0| 0| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 5| 2| 7| 7| 6| 6| 2|             
                             DAY ON TEST   | 3| 7| 1| 0| 0| 3| 3| 3| 3| 0| 3| 3| 2| 2| 3| 3| 3| 7| 8| 8| 3| 3| 6| 0| 0|             
                                           | 2| 4| 1| 9| 5| 2| 2| 2| 2| 3| 2| 2| 6| 6| 2| 2| 2| 8| 6| 3| 2| 2| 3| 6| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    100MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
     HIGHFEM                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Atrophy                              |                                                                          |             
      Congestion                           |                                                                          |             
      Cyst                                 |                      3                                                   |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hemorrhage                           |                            2                                             |             
                                            __________________________________________________________________________|             
   Vagina                                  |                            +                                             |             
      Inflammation, Acute                  |                            2                                             |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                      2   |             
      Hyperplasia, Reticulum Cell          |       2                                                                  |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mediastinal, Foreign Body            |                                                                          |             
      Mediastinal, Hemorrhage              |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M|             
      Congestion                           |             2                                                            |             
      Cyst                                 |                                              2                           |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis, Focal                      |                                              2                           |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Inflammation, Chronic                |                               2                                          |             
      Pigmentation                         |                               2                          1              2|             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Hemorrhage                           |                                                          2              2|             
      Necrosis                             |       2  2                                                               |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |    2                                                                     |             
      Hyperplasia                          |    2                                                                     |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Acute                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  35                                                               
NTP Experiment-Test: 05041-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 11:52:17  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 1| 0| 0| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 5| 2| 7| 7| 6| 6| 2|             
                             DAY ON TEST   | 3| 7| 1| 0| 0| 3| 3| 3| 3| 0| 3| 3| 2| 2| 3| 3| 3| 7| 8| 8| 3| 3| 6| 0| 0|             
                                           | 2| 4| 1| 9| 5| 2| 2| 2| 2| 3| 2| 2| 6| 6| 2| 2| 2| 8| 6| 3| 2| 2| 3| 6| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    100MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
     HIGHFEM                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Thrombosis, Multifocal               |                                                                          |             
      Meninges, Infiltration Cellular,     |                                                                          |             
           Lymphocyte                      |                                                                   2      |             
      Pons, Vacuolization Cytoplasmic      |                                                       2                  |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |             2                                                            |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |       4     2              3                       3                     |             
      Edema                                |       2                                                                  |             
      Fibrosis, Focal                      |                                              1                           |             
      Foreign Body                         |                         2                    1                          2|             
      Hemorrhage                           |          2                                                               |             
      Hyperplasia, Adenomatous             |                                           1                              |             
      Infiltration Cellular, Histiocyte    | 1  1                 1           1              1  1  1     1     1      |             
      Inflammation, Acute                  |                                                          2               |             
      Inflammation, Chronic                |                         2                                                |             
      Pigmentation                         |                                           2                              |             
      Bronchiole, Foreign Body             |                                                                          |             
      Bronchiole, Inflammation, Acute      |                                                                          |             
      Bronchiole, Inflammation, Subacute   |                                                                          |             
      Mediastinum, Foreign Body            |                                                                          |             
      Mediastinum, Hemorrhage              |                                                                          |             
      Mediastinum, Inflammation, Chronic   |                                                                          |             
          Active                           |          4                                                               |             
      Mediastinum, Necrosis                |       2                                                                  |             
      Pleura, Fibrosis                     |                                                                         4|             
      Pleura, Inflammation, Chronic Active |                                                                          |             
      Pleura, Necrosis                     |       3  4  2                                                            |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Sinus, Foreign Body                  |                                              2  2                       2|             
      Sinus, Fungus                        |                                              2                           |             
      Sinus, Hemorrhage                    |                                                                          |             
      Sinus, Inflammation, Acute           |                                              2  2                 2      |             
      Turbinate, Inflammation, Subacute    |                                                                          |             
      Turbinate, Necrosis                  |                                                                         2|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |             2                                                            |             
      Inflammation, Chronic                |                                                                          |             
      Necrosis                             |                                                          4              4|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  36                                                               
NTP Experiment-Test: 05041-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 11:52:17  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 1| 0| 0| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 5| 2| 7| 7| 6| 6| 2|             
                             DAY ON TEST   | 3| 7| 1| 0| 0| 3| 3| 3| 3| 0| 3| 3| 2| 2| 3| 3| 3| 7| 8| 8| 3| 3| 6| 0| 0|             
                                           | 2| 4| 1| 9| 5| 2| 2| 2| 2| 3| 2| 2| 6| 6| 2| 2| 2| 8| 6| 3| 2| 2| 3| 6| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    100MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
     HIGHFEM                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                     +                                    |             
      Lens Capsule, Cataract               |                                     2                                    |             
      Retina, Atrophy                      |                                     3                                    |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Nephropathy                          |    2                             1     1                                 |             
      Pigmentation                         |                                                                          |             
      Pelvis, Mineralization               |                      1                                                   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  37                                                               
NTP Experiment-Test: 05041-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 11:52:17  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 7| 7| 7| 6| 4| 0|                                            |            |
                             DAY ON TEST   | 3| 3| 2| 3| 3| 3| 3| 4| 1| 0|                                            |            |
                                           | 2| 2| 9| 2| 2| 2| 2| 2| 7| 5|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |      A     |
    100MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
     HIGHFEM                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Inflammation, Chronic                |             2              1                                             |      3  2.3|
      Adventitia, Fibrosis                 |                                                                          |      1  4.0|
      Muscularis, Regeneration             |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  A  +  +  +  +  +  +  +                                             |  55        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  A  +  +  +  +  +  +  +                                             |  53        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  A  +  +  +  +  +  +  +                                             |  55        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  A  +  +  +  +  +  +  +                                             |  53        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  A  +  +  +  +  +  +  +                                             |  52        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  A  +  +  +  +  +  +  +                                             |  52        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  A  +  +  +  +  +  +  +                                             |  51        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  A  +  +  +  +  +  +  +                                             |  51        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Basophilic Focus, Multiple           | X  X     X  X  X  X  X                                                   |     25     |
      Congestion                           |                                                                          |      3  2.0|
      Cytologic Alterations                |                                                                          |      6     |
      Fibrosis, Focal                      |                                                                          |     10  1.7|
      Hepatodiaphragmatic Nodule           |                      X                                                   |     14     |
      Hyperplasia, Nodular                 |             2                                                            |      1  2.0|
      Inflammation, Acute                  |                                                                          |      1  2.0|
      Inflammation, Chronic                | 2  2        2                                                            |     15  1.7|
      Necrosis, Multifocal                 |       3                                                                  |      2  2.5|
      Vacuolization Cytoplasmic            |                                                                          |      4  2.8|
      Bile Duct, Hyperplasia               |                                                                          |      9  1.6|
      Centrilobular, Congestion            |                                                                          |      1  2.0|
      Centrilobular, Vacuolization         |                                                                          |            |
          Cytoplasmic                      |                                                                          |      1  3.0|
      Hepatocyte, Inclusion Body           |                                                                          |            |
          Intranuclear                     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               | +                                                                        |   3        |
      Hemorrhage                           |                                                                          |      1  3.0|
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Fat, Necrosis                        | 3                                                                        |      2  2.5|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  A  +  +  +  +  +  +  +                                             |  59        |
      Cyst                                 |                                                                          |      1  1.0|
      Hemorrhage                           |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                                                          |      1  1.0|
      Acinus, Atrophy, Focal               |                         1                                                |      5  1.2|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  59        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  38                                                               
NTP Experiment-Test: 05041-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 11:52:17  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 7| 7| 7| 6| 4| 0|                                            |            |
                             DAY ON TEST   | 3| 3| 2| 3| 3| 3| 3| 4| 1| 0|                                            |            |
                                           | 2| 2| 9| 2| 2| 2| 2| 2| 7| 5|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |      A     |
    100MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
     HIGHFEM                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +                                             |  58        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  A  +  +  +  +  +  +  +                                             |  57        |
      Erosion, Acute                       |                                                                          |      1  2.0|
      Hyperplasia, Focal                   |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  M  +  +  +  +  A  +  +                                             |  54        |
      Epithelium, Cyst                     |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cardiomyopathy                       | 2  2           1  1  1                                                   |     21  1.3|
      Atrium, Thrombosis                   |    2                                                                     |      1  2.0|
      Coronary Artery, Inflammation,       |                                                                          |            |
          Chronic                          |          2                                                               |      1  2.0|
      Epicardium, Foreign Body             |                                                                          |      2  2.0|
      Epicardium, Inflammation, Acute      |                            1                                             |      2  1.5|
      Epicardium, Inflammation, Chronic    |                                                                          |            |
          Active                           |                                                                          |      3  3.3|
      Epicardium, Necrosis                 |                                                                          |      2  2.5|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Congestion                           |       2                                                                  |      2  2.0|
      Hyperplasia                          |                      3                                                   |      2  2.5|
      Hypertrophy                          |                                                                          |      1  3.0|
      Necrosis, Focal                      |                                                                          |      1  2.0|
      Vacuolization Cytoplasmic, Focal     |       3           2                                                      |      6  2.3|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +                                             |  54        |
      Hyperplasia                          |                                                                          |      9  1.1|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  M  +  M  +  +  +  +  +                                             |  44        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hemorrhage                           |                                                                          |      1  2.0|
      Pars Distalis, Angiectasis           |          2     2        2                                                |      8  2.0|
      Pars Distalis, Cyst                  |    2                                                                     |      3  2.0|
      Pars Distalis, Degeneration, Focal   |                                                                          |      1  1.0|
      Pars Distalis, Hyperplasia           |          2  4                                                            |      7  2.1|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  39                                                               
NTP Experiment-Test: 05041-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 11:52:17  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 7| 7| 7| 6| 4| 0|                                            |            |
                             DAY ON TEST   | 3| 3| 2| 3| 3| 3| 3| 4| 1| 0|                                            |            |
                                           | 2| 2| 9| 2| 2| 2| 2| 2| 7| 5|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |      A     |
    100MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
     HIGHFEM                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      C-Cell, Hyperplasia                  |                                                                          |      5  1.2|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +                                             |  53        |
      Dilatation                           |          2                                                               |      1  2.0|
      Inflammation, Acute                  |                      2                                                   |      1  2.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Atrophy                              |                                                                          |      2  1.5|
      Congestion                           |                      3     2                                             |      2  2.5|
      Cyst                                 |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Congestion                           |                            2                                             |      1  2.0|
      Hemorrhage                           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Vagina                                  |                                                                          |   1        |
      Inflammation, Acute                  |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperplasia                          |                                                                          |      1  2.0|
      Hyperplasia, Reticulum Cell          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Mediastinal, Foreign Body            |                                                                          |      2  2.0|
      Mediastinal, Hemorrhage              |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  M  +  +  +                                             |  55        |
      Congestion                           |                                                                          |      1  2.0|
      Cyst                                 |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Hemorrhage                           |                                                                          |      3  2.7|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Fibrosis, Focal                      |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Pigmentation                         |       2                                                                  |      9  1.7|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +                                             |  52        |
      Hemorrhage                           |                                                                          |      2  2.0|
      Necrosis                             |                                                                          |      2  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  40                                                               
NTP Experiment-Test: 05041-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 11:52:17  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 7| 7| 7| 6| 4| 0|                                            |            |
                             DAY ON TEST   | 3| 3| 2| 3| 3| 3| 3| 4| 1| 0|                                            |            |
                                           | 2| 2| 9| 2| 2| 2| 2| 2| 7| 5|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |      A     |
    100MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
     HIGHFEM                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Dilatation                           |                                                                          |      1  2.0|
      Hyperplasia                          |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Acute                           |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Thrombosis, Multifocal               |                                                                          |      1  2.0|
      Meninges, Infiltration Cellular,     |                                                                          |            |
           Lymphocyte                      |                                                                          |      1  2.0|
      Pons, Vacuolization Cytoplasmic      |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                         +                                                |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Inflammation, Chronic                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Congestion                           |                      3  2                                                |      9  2.6|
      Edema                                |                            2                                             |      2  2.0|
      Fibrosis, Focal                      |                                                                          |      1  1.0|
      Foreign Body                         |                      2                                                   |      8  1.9|
      Hemorrhage                           |                            2                                             |      3  2.3|
      Hyperplasia, Adenomatous             | 1                                                                        |      4  1.3|
      Infiltration Cellular, Histiocyte    | 1        1  1  1  1                                                      |     24  1.1|
      Inflammation, Acute                  |                      2                                                   |      3  2.3|
      Inflammation, Chronic                |    2                                                                     |      2  2.0|
      Pigmentation                         |                                                                          |      2  1.5|
      Bronchiole, Foreign Body             |       2                                                                  |      1  2.0|
      Bronchiole, Inflammation, Acute      |       3                                                                  |      2  3.0|
      Bronchiole, Inflammation, Subacute   |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  41                                                               
NTP Experiment-Test: 05041-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 11:52:17  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 7| 7| 7| 6| 4| 0|                                            |            |
                             DAY ON TEST   | 3| 3| 2| 3| 3| 3| 3| 4| 1| 0|                                            |            |
                                           | 2| 2| 9| 2| 2| 2| 2| 2| 7| 5|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |      A     |
    100MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
     HIGHFEM                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Mediastinum, Foreign Body            |                                                                          |      1  2.0|
      Mediastinum, Hemorrhage              |                                                                          |      1  4.0|
      Mediastinum, Inflammation, Chronic   |                                                                          |            |
          Active                           |                                                                          |      3  3.7|
      Mediastinum, Necrosis                |                                                                          |      1  2.0|
      Pleura, Fibrosis                     |                2                                                         |      3  2.7|
      Pleura, Inflammation, Chronic Active |                                                                          |      2  2.0|
      Pleura, Necrosis                     |                            2                                             |      4  2.8|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  57        |
      Sinus, Foreign Body                  |       3                                                                  |      5  2.2|
      Sinus, Fungus                        |                                                                          |      2  2.0|
      Sinus, Hemorrhage                    |                      2                                                   |      1  2.0|
      Sinus, Inflammation, Acute           |       3                 1                                                |      9  2.1|
      Turbinate, Inflammation, Subacute    |                                                                          |      2  2.0|
      Turbinate, Necrosis                  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hemorrhage                           |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                                                          |      1  1.0|
      Necrosis                             |                         4                                                |      5  3.8|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                +                                                         |   4        |
      Lens Capsule, Cataract               |                2                                                         |      4  2.0|
      Retina, Atrophy                      |                2                                                         |      4  2.5|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cyst                                 |                2                                                         |      1  2.0|
      Nephropathy                          |          1                                                               |      9  1.1|
      Pigmentation                         |                                                                          |      1  3.0|
      Pelvis, Mineralization               |                                                                          |      3  1.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  42                                                               
NTP Experiment-Test: 05041-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 11:52:17  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 2| 1| 4| 2| 2| 2| 2| 7| 2| 2| 2| 4| 8| 2| 2| 2| 2| 2| 2| 2| 0| 2| 2|             
                                           | 9| 9| 9| 1| 9| 9| 9| 9| 9| 5| 9| 9| 9| 6| 1| 9| 9| 9| 9| 9| 9| 9| 6| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis, Focal                      |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | M  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A  +  +|             
      Foreign Body                         |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                          1               |             
      Basophilic Focus                     |    X                                                                    X|             
      Basophilic Focus, Multiple           | X     X           X  1        X                                          |             
      Cytologic Alterations                |    X                                                                     |             
      Cytologic Alterations, Multiple      |                                                                X         |             
      Fibrosis, Focal                      |       2  1                                      1                        |             
      Hemorrhage                           |       2                                                                  |             
      Hepatodiaphragmatic Nodule           |       X  X                                      X                        |             
      Hyperplasia, Focal                   |                                                                         2|             
      Hyperplasia, Nodular                 |                                                                          |             
      Inflammation, Chronic                |       2                          1  1        1                           |             
      Necrosis, Focal                      |                                                                          |             
      Necrosis, Multifocal                 |                                                                          |             
      Vacuolization Cytoplasmic            |       2                                1                                 |             
      Bile Duct, Cyst                      |                                                                          |             
      Bile Duct, Hyperplasia               | 2  1  2  1     2  1  2  1  2  2  1  1  2           1  2     2     1  2  2|             
      Centrilobular, Necrosis              |                                                                          |             
      Centrilobular, Vacuolization         |                                                                          |             
          Cytoplasmic                      |                   1                                                      |             
                                            __________________________________________________________________________|             
   Mesentery                               |             +           +  +     +                          +           +|             
      Inflammation, Chronic                |                                                                          |             
      Fat, Necrosis                        |             3           2  2     3                          2           2|             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Acinus, Atrophy, Diffuse             |                                                                          |             
      Acinus, Atrophy, Focal               |    1                 2        1        1     1  1  2        1           2|             
      Acinus, Hyperplasia, Focal           |                                                                          |             
      Artery, Inflammation, Chronic        |                                                                          |             
      Artery, Inflammation, Chronic Active |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Cyst                                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  43                                                               
NTP Experiment-Test: 05041-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 11:52:17  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 2| 1| 4| 2| 2| 2| 2| 7| 2| 2| 2| 4| 8| 2| 2| 2| 2| 2| 2| 2| 0| 2| 2|             
                                           | 9| 9| 9| 1| 9| 9| 9| 9| 9| 5| 9| 9| 9| 6| 1| 9| 9| 9| 9| 9| 9| 9| 6| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Chronic                |                   1  1                                                   |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  A  +  +|             
      Edema                                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |    2  2  2     1  1  2  1  1  2  2  2  2  2  2  1  1  2  1        2  2  3|             
      Atrium, Thrombosis                   |                               4                                3         |             
      Epicardium, Inflammation, Chronic    |                                                                          |             
          Active                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Hypertrophy, Focal                   |                                                                          |             
      Necrosis, Focal                      |                                                                          |             
      Vacuolization Cytoplasmic, Focal     |                                                          1  2            |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    1              1     2  2  1        1        1        2  2            |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                            1                                             |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  M  +  +  +  M  +  +|             
      Hyperplasia                          |                                              2                           |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  M  +  +|             
      Hemorrhage                           |                                                                          |             
      Pars Distalis, Angiectasis           |                                     1                                    |             
      Pars Distalis, Hyperplasia           |          2                    2                             1            |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Inflammation, Chronic                |                                                    1                     |             
      C-Cell, Hyperplasia                  |    1  1                                         1           1            |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                   +      |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  44                                                               
NTP Experiment-Test: 05041-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 11:52:17  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 2| 1| 4| 2| 2| 2| 2| 7| 2| 2| 2| 4| 8| 2| 2| 2| 2| 2| 2| 2| 0| 2| 2|             
                                           | 9| 9| 9| 1| 9| 9| 9| 9| 9| 5| 9| 9| 9| 6| 1| 9| 9| 9| 9| 9| 9| 9| 6| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Serosa, Hyperplasia, Focal           |                                                          2               |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  M  +  +  +  +  +  +  M  M  +  +  M  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                                                          |             
      Hyperplasia                          |       2                                                                  |             
      Inflammation, Acute                  |       3                                               1                  |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Hyperplasia                          | 1                    1        1                                          |             
      Inflammation, Acute                  |    2                                         2                           |             
      Inflammation, Chronic                |                                     1                                    |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
      Hyperplasia, Reticulum Cell          |                1                                                         |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mediastinal, Giant Cell, Multiple    |                         2                                                |             
      Mediastinal, Hemorrhage              |                                              2                           |             
      Mediastinal, Hyperplasia             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  M  +  +  M  M  +|             
      Cyst                                 |                                  2                                      2|             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                | 2                    1                       2  2                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis, Focal                      |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hemorrhage                           |                2                                                         |             
      Hyperplasia, Nodular                 |                                                                          |             
      Pigmentation                         |                                        2              1                  |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  M  +  +  +  M  M  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  M|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +  M  +  +  M|             
      Dilatation                           |                                        2        2        2               |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Sternum, Hemorrhage                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  45                                                               
NTP Experiment-Test: 05041-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 11:52:17  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 2| 1| 4| 2| 2| 2| 2| 7| 2| 2| 2| 4| 8| 2| 2| 2| 2| 2| 2| 2| 0| 2| 2|             
                                           | 9| 9| 9| 1| 9| 9| 9| 9| 9| 5| 9| 9| 9| 6| 1| 9| 9| 9| 9| 9| 9| 9| 6| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Thrombosis, Multifocal               |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
      Nerve, Demyelination                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                           4                              |             
      Fibrosis, Focal                      |                         1                                                |             
      Hyperplasia, Adenomatous             |          2        2  1  2                                                |             
      Infiltration Cellular, Histiocyte    |    1  1              1  2           1                 1                  |             
      Metaplasia, Osseous                  |                                                                          |             
      Pigmentation                         |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                              3                           |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Inflammation, Chronic Active         |                                                 3                        |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Acute                           |                                                                          |             
      Sinus, Foreign Body                  |                                                                          |             
      Sinus, Fungus                        |                                                 3                        |             
      Sinus, Inflammation, Acute           |                                  2                       2     2         |             
      Turbinate, Foreign Body              |                            2                                             |             
      Turbinate, Inflammation, Acute       |       2                                                                  |             
      Turbinate, Inflammation, Chronic     |                                              2                           |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     | +     +                       +                                      +   |             
      Lens Capsule, Cataract               |       3                       2                                      2   |             
      Retina, Atrophy                      | 3     3                       3                                      2   |             
      Sclera, Metaplasia, Osseous          | 2     1                       2                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                      +   |             
      Inflammation, Chronic, Focal         |                                                                      2   |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                       1                  |             
      Cyst                                 |                                        2                                 |             
      Hydronephrosis                       |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Mineralization                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  46                                                               
NTP Experiment-Test: 05041-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 11:52:17  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 2| 1| 4| 2| 2| 2| 2| 7| 2| 2| 2| 4| 8| 2| 2| 2| 2| 2| 2| 2| 0| 2| 2|             
                                           | 9| 9| 9| 1| 9| 9| 9| 9| 9| 5| 9| 9| 9| 6| 1| 9| 9| 9| 9| 9| 9| 9| 6| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Nephropathy                          | 3  2  2  1     1  2  2  1     2  1  1  2     1  1  1  1  3  2  2  2  2  1|             
      Papilla, Necrosis                    |                                                                          |             
      Pelvis, Dilatation                   |                                                                          |             
      Pelvis, Inflammation, Acute          |                                                                          |             
      Renal Tubule, Pigmentation           |             2                                                            |             
                                            __________________________________________________________________________|             
   Ureter                                  |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  47                                                               
NTP Experiment-Test: 05041-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 11:52:17  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 6| 7| 7| 6| 6| 5| 7| 7| 7| 3| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5|             
                             DAY ON TEST   | 2| 2| 9| 8| 4| 2| 2| 3| 3| 9| 2| 1| 0| 6| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 9|             
                                           | 9| 9| 1| 1| 2| 9| 9| 2| 2| 0| 9| 5| 8| 4| 2| 9| 3| 9| 9| 9| 9| 9| 9| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    CONTROL                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis, Focal                      |                                                 2                        |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  M  +  +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  M  +  +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  M  +  +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                     2                                    |             
      Inflammation, Chronic                |                                     2                                    |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  M  +  +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                1                                                         |             
      Basophilic Focus                     |       X        X                                                         |             
      Basophilic Focus, Multiple           |    X              X     1     X           X           X  X  X  X         |             
      Cytologic Alterations                |                                                                          |             
      Cytologic Alterations, Multiple      |                   X                                      X        X  X   |             
      Fibrosis, Focal                      |                                                 1                        |             
      Hemorrhage                           |                                                                          |             
      Hepatodiaphragmatic Nodule           |                               X                       X                  |             
      Hyperplasia, Focal                   |       2                                                                  |             
      Hyperplasia, Nodular                 | 2                                                                        |             
      Inflammation, Chronic                |                                                    2           1         |             
      Necrosis, Focal                      |                                                                   1      |             
      Necrosis, Multifocal                 |                                                                2         |             
      Vacuolization Cytoplasmic            |                                                    2        2           2|             
      Bile Duct, Cyst                      |                                                                      3   |             
      Bile Duct, Hyperplasia               |       2  2  2  2  1     2  2     1     1  1  2  2     1  2  2  2  2  1  2|             
      Centrilobular, Necrosis              |                                     3                                    |             
      Centrilobular, Vacuolization         |                                                                          |             
          Cytoplasmic                      |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               | +                 +                 +           +              +         |             
      Inflammation, Chronic                | 2                                   2                                    |             
      Fat, Necrosis                        | 2                 2                             2              2         |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                | 1                                                                        |             
      Acinus, Atrophy, Diffuse             | 3                                                                        |             
      Acinus, Atrophy, Focal               |    2  1     1        2        2     1              1     1        1  1   |             
      Acinus, Hyperplasia, Focal           |                                                                          |             
      Artery, Inflammation, Chronic        |          3                                                               |             
      Artery, Inflammation, Chronic Active |    2                                                                     |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  48                                                               
NTP Experiment-Test: 05041-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 11:52:17  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 6| 7| 7| 6| 6| 5| 7| 7| 7| 3| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5|             
                             DAY ON TEST   | 2| 2| 9| 8| 4| 2| 2| 3| 3| 9| 2| 1| 0| 6| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 9|             
                                           | 9| 9| 1| 1| 2| 9| 9| 2| 2| 0| 9| 5| 8| 4| 2| 9| 3| 9| 9| 9| 9| 9| 9| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    CONTROL                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |          2                                                               |             
      Inflammation, Chronic Active         |                                     4                                    |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                      2                                                   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 2  1     2  1  2  2     2  2  2     1     1  2  2  2  1  2  1  2  1  2   |             
      Atrium, Thrombosis                   |                                                 4                        |             
      Epicardium, Inflammation, Chronic    |                                                                          |             
          Active                           |                                                    2                     |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    1           3  2           1                                   3  2   |             
      Hypertrophy, Focal                   |                                                    2                     |             
      Necrosis, Focal                      |                                                                         2|             
      Vacuolization Cytoplasmic, Focal     |                                                             3            |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |       1     1  1  1  2           2        2              2     2     2   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                      1   |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  M  M  +  M  +  +  +  M  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Pars Distalis, Angiectasis           |                                                    2                     |             
      Pars Distalis, Hyperplasia           |       1        2           2  2           2                              |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                   2                                                  2   |             
      Inflammation, Chronic                |                1                                                         |             
      C-Cell, Hyperplasia                  |    1  1                                               1        1  1      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                        +                                 |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  49                                                               
NTP Experiment-Test: 05041-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 11:52:17  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 6| 7| 7| 6| 6| 5| 7| 7| 7| 3| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5|             
                             DAY ON TEST   | 2| 2| 9| 8| 4| 2| 2| 3| 3| 9| 2| 1| 0| 6| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 9|             
                                           | 9| 9| 1| 1| 2| 9| 9| 2| 2| 0| 9| 5| 8| 4| 2| 9| 3| 9| 9| 9| 9| 9| 9| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    CONTROL                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Serosa, Hyperplasia, Focal           |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  M  +  +  +  +  M  +  +  M  +  +  +  +  +  +  M  +  +  +|             
      Dilatation                           |          3                                                               |             
      Hyperplasia                          |                                                                          |             
      Inflammation, Acute                  |          2                                                           2  1|             
      Inflammation, Chronic                |                                                 1                        |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 2                                                           1  3         |             
      Inflammation, Acute                  |                                                                2         |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                      2                                                   |             
      Hyperplasia, Reticulum Cell          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mediastinal, Giant Cell, Multiple    |                                                                          |             
      Mediastinal, Hemorrhage              |                                                       2                  |             
      Mediastinal, Hyperplasia             |                                                 2                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                               2                       2     2            |             
      Hemorrhage                           |                                                    2                     |             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis, Focal                      |                            2                                2            |             
      Hematopoietic Cell Proliferation     |                                                 2                        |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Nodular                 |                                     2                                    |             
      Pigmentation                         |                         2        1                                       |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  M  +  +  M  M  +  +  +  +  +  +  +  +  +  M  +  M  M  +  +  +  M  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +|             
      Dilatation                           |                                     2                       2            |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |       2                                                                  |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Sternum, Hemorrhage                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  50                                                               
NTP Experiment-Test: 05041-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 11:52:17  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 6| 7| 7| 6| 6| 5| 7| 7| 7| 3| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5|             
                             DAY ON TEST   | 2| 2| 9| 8| 4| 2| 2| 3| 3| 9| 2| 1| 0| 6| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 9|             
                                           | 9| 9| 1| 1| 2| 9| 9| 2| 2| 0| 9| 5| 8| 4| 2| 9| 3| 9| 9| 9| 9| 9| 9| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    CONTROL                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Thrombosis, Multifocal               |                            2                                             |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |          +              +              +                                 |             
      Nerve, Demyelination                 |          2                                                               |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |             2                                                            |             
      Fibrosis, Focal                      |                                                                          |             
      Hyperplasia, Adenomatous             |                               2  2                          1     1      |             
      Infiltration Cellular, Histiocyte    |                                     1     2        1  1                 1|             
      Metaplasia, Osseous                  |                               1           2                              |             
      Pigmentation                         |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                                          3               |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Acute                           |                                                 2                 2      |             
      Sinus, Foreign Body                  |                                                                2         |             
      Sinus, Fungus                        |                                                                          |             
      Sinus, Inflammation, Acute           |                                  2  1                          2         |             
      Turbinate, Foreign Body              |                                                                          |             
      Turbinate, Inflammation, Acute       |                                                                          |             
      Turbinate, Inflammation, Chronic     |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                                  2                                       |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     | +        +                                      +                 +      |             
      Lens Capsule, Cataract               |                                                                   2      |             
      Retina, Atrophy                      | 2        2                                      2                 3      |             
      Sclera, Metaplasia, Osseous          | 1                                                                        |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                   +      |             
      Inflammation, Chronic, Focal         |                                                                   1      |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                                          |             
      Cyst                                 |    3                                   2                                 |             
      Hydronephrosis                       |                                        3                                 |             
      Inflammation, Chronic                |                                                 2                        |             
      Mineralization                       |                                        1                                 |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  51                                                               
NTP Experiment-Test: 05041-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 11:52:17  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 6| 7| 7| 6| 6| 5| 7| 7| 7| 3| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5|             
                             DAY ON TEST   | 2| 2| 9| 8| 4| 2| 2| 3| 3| 9| 2| 1| 0| 6| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 9|             
                                           | 9| 9| 1| 1| 2| 9| 9| 2| 2| 0| 9| 5| 8| 4| 2| 9| 3| 9| 9| 9| 9| 9| 9| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    CONTROL                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Nephropathy                          | 2  2  1     1  1  2  1  1     2  2  2        2  1  2  3  1  2  1  1  2  2|             
      Papilla, Necrosis                    |                                        2                                 |             
      Pelvis, Dilatation                   |                                                                4         |             
      Pelvis, Inflammation, Acute          |                         1                                                |             
      Renal Tubule, Pigmentation           |                                                                          |             
                                            __________________________________________________________________________|             
   Ureter                                  |                                        +                                 |             
      Inflammation, Acute                  |                                        3                                 |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                         4              4                                 |             
      Inflammation, Acute                  |                                        2                                 |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  52                                                               
NTP Experiment-Test: 05041-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 11:52:17  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 6| 6| 7| 7| 6| 1| 7|                                            |            |
                             DAY ON TEST   | 2| 2| 9| 9| 0| 2| 1| 6| 4| 2|                                            |            |
                                           | 9| 9| 6| 1| 3| 9| 6| 1| 5| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Fibrosis, Focal                      |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  A  +  A  +  +  +                                             |  54        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  A  +  A  +  M  +                                             |  52        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  A  +  A  +  +  +                                             |  54        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  A  +  A  +  M  +                                             |  51        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  A  +  A  +  +  +                                             |  54        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  A  +  A  +  A  +                                             |  52        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  A  +  A  +  M  +                                             |  53        |
      Foreign Body                         |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  A  +  A  +  M  +                                             |  52        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Angiectasis                          |                      2                                                   |      3  1.3|
      Basophilic Focus                     |                                                                          |      4     |
      Basophilic Focus, Multiple           |                X                                                         |     15  1.0|
      Cytologic Alterations                | X                                                                        |      2     |
      Cytologic Alterations, Multiple      |                                                                          |      5     |
      Fibrosis, Focal                      |             2                                                            |      5  1.4|
      Hemorrhage                           |                                                                          |      1  2.0|
      Hepatodiaphragmatic Nodule           |             X                                                            |      6     |
      Hyperplasia, Focal                   |                                                                          |      2  2.0|
      Hyperplasia, Nodular                 |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                                                          |      6  1.3|
      Necrosis, Focal                      |                                                                          |      1  1.0|
      Necrosis, Multifocal                 |                                                                          |      1  2.0|
      Vacuolization Cytoplasmic            |             2                                                            |      6  1.8|
      Bile Duct, Cyst                      |                                                                          |      1  3.0|
      Bile Duct, Hyperplasia               | 1              1  2        1                                             |     42  1.6|
      Centrilobular, Necrosis              |                                                                          |      1  3.0|
      Centrilobular, Vacuolization         |                                                                          |            |
          Cytoplasmic                      |                      1                                                   |      2  1.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               | +              +                                                         |  13        |
      Inflammation, Chronic                |                                                                          |      2  2.0|
      Fat, Necrosis                        | 1              2                                                         |     12  2.1|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Inflammation, Chronic                |                                                                          |      1  1.0|
      Acinus, Atrophy, Diffuse             |                                                                          |      1  3.0|
      Acinus, Atrophy, Focal               | 1  2  1                                                                  |     22  1.3|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  53                                                               
NTP Experiment-Test: 05041-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 11:52:17  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 6| 6| 7| 7| 6| 1| 7|                                            |            |
                             DAY ON TEST   | 2| 2| 9| 9| 0| 2| 1| 6| 4| 2|                                            |            |
                                           | 9| 9| 6| 1| 3| 9| 6| 1| 5| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Acinus, Hyperplasia, Focal           | 1                                                                        |      1  1.0|
      Artery, Inflammation, Chronic        |                                                                          |      1  3.0|
      Artery, Inflammation, Chronic Active |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Cyst                                 |    2                                                                     |      1  2.0|
      Hemorrhage                           |    2                                                                     |      1  2.0|
      Inflammation, Chronic                |                                                                          |      2  1.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Inflammation, Chronic                |             2                                                            |      2  2.0|
      Inflammation, Chronic Active         |                                                                          |      1  4.0|
      Ulcer                                |          1           3                                                   |      2  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Edema                                |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cardiomyopathy                       | 2  2        2  1     1     2                                             |     47  1.7|
      Atrium, Thrombosis                   |                                                                          |      3  3.7|
      Epicardium, Inflammation, Chronic    |                                                                          |            |
          Active                           |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperplasia                          |                                                                          |      6  2.0|
      Hypertrophy, Focal                   |                                                                          |      1  2.0|
      Necrosis, Focal                      |                                                                          |      1  2.0|
      Vacuolization Cytoplasmic, Focal     |          2                                                               |      4  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  M  +                                             |  58        |
      Hyperplasia                          |    2                 1                                                   |     21  1.5|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Hyperplasia                          |                                                                          |      2  1.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  M  +  +  +  +  +  +  +  +                                             |  51        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  57        |
      Hemorrhage                           |             2                                                            |      1  2.0|
      Pars Distalis, Angiectasis           |                                                                          |      2  1.5|
      Pars Distalis, Hyperplasia           |                                                                          |      8  1.8|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  54                                                               
NTP Experiment-Test: 05041-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 11:52:17  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 6| 6| 7| 7| 6| 1| 7|                                            |            |
                             DAY ON TEST   | 2| 2| 9| 9| 0| 2| 1| 6| 4| 2|                                            |            |
                                           | 9| 9| 6| 1| 3| 9| 6| 1| 5| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cyst                                 |                                                                          |      2  2.0|
      Inflammation, Chronic                |                                                                          |      2  1.0|
      C-Cell, Hyperplasia                  | 1                          1                                             |     11  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Serosa, Hyperplasia, Focal           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  M  +  +  +  M  M  M  +                                             |  48        |
      Dilatation                           |                                                                          |      1  3.0|
      Hyperplasia                          |                                                                          |      1  2.0|
      Inflammation, Acute                  |                                                                          |      5  1.8|
      Inflammation, Chronic                |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Hyperplasia                          |                   2                                                      |      7  1.6|
      Inflammation, Acute                  |                                                                          |      3  2.0|
      Inflammation, Chronic                |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  M  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Fibrosis                             |                                                                          |      1  2.0|
      Hyperplasia, Reticulum Cell          |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Mediastinal, Giant Cell, Multiple    |                                                                          |      1  2.0|
      Mediastinal, Hemorrhage              |                         4                                                |      3  2.7|
      Mediastinal, Hyperplasia             |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  M  M                                             |  50        |
      Cyst                                 |                                                                          |      5  2.0|
      Hemorrhage                           |                                                                          |      1  2.0|
      Hyperplasia, Lymphoid                |                                                                          |      4  1.8|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  M  +  +  +                                             |  57        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Fibrosis, Focal                      |                                                                          |      2  2.0|
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  55                                                               
NTP Experiment-Test: 05041-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 11:52:17  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 6| 6| 7| 7| 6| 1| 7|                                            |            |
                             DAY ON TEST   | 2| 2| 9| 9| 0| 2| 1| 6| 4| 2|                                            |            |
                                           | 9| 9| 6| 1| 3| 9| 6| 1| 5| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Hemorrhage                           |                                                                          |      1  2.0|
      Hyperplasia, Nodular                 |                                                                          |      1  2.0|
      Pigmentation                         |                                                                          |      4  1.5|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  M  M  +  +  +                                             |  45        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  M  +  +  +  +  +  M  M                                             |  48        |
      Dilatation                           |                                                                          |      5  2.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Sternum, Hemorrhage                  |                         2                                                |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Thrombosis, Multifocal               |       2                                                                  |      2  2.0|
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   3        |
      Nerve, Demyelination                 |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Congestion                           |             2     4     2                                                |      5  2.8|
      Fibrosis, Focal                      |                                                                          |      1  1.0|
      Hyperplasia, Adenomatous             |    1                       2                                             |     10  1.6|
      Infiltration Cellular, Histiocyte    |                2                                                         |     12  1.3|
      Metaplasia, Osseous                  |                                                                          |      2  1.5|
      Pigmentation                         |                            2                                             |      1  2.0|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  M  +                                             |  58        |
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Acute                           |                                                                          |      2  2.0|
      Sinus, Foreign Body                  |                                                                          |      1  2.0|
      Sinus, Fungus                        |                                                                          |      1  3.0|
      Sinus, Inflammation, Acute           |             2                                                            |      7  1.9|
      Turbinate, Foreign Body              |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  56                                                               
NTP Experiment-Test: 05041-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 11:52:17  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 6| 6| 7| 7| 6| 1| 7|                                            |            |
                             DAY ON TEST   | 2| 2| 9| 9| 0| 2| 1| 6| 4| 2|                                            |            |
                                           | 9| 9| 6| 1| 3| 9| 6| 1| 5| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Turbinate, Inflammation, Acute       |                                                                          |      1  2.0|
      Turbinate, Inflammation, Chronic     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Inflammation, Acute                  |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   8        |
      Lens Capsule, Cataract               |                                                                          |      4  2.3|
      Retina, Atrophy                      |                                                                          |      8  2.5|
      Sclera, Metaplasia, Osseous          |                                                                          |      4  1.5|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   2        |
      Inflammation, Chronic, Focal         |                                                                          |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Abscess                              |                                                                          |      1  1.0|
      Cyst                                 |                      2                                                   |      4  2.3|
      Hydronephrosis                       |                                                                          |      1  3.0|
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Mineralization                       |                                                                          |      1  1.0|
      Nephropathy                          | 2  1  1     2  2  3  4  1  1                                             |     52  1.7|
      Papilla, Necrosis                    |                                                                          |      1  2.0|
      Pelvis, Dilatation                   |                                                                          |      1  4.0|
      Pelvis, Inflammation, Acute          |                                                                          |      1  1.0|
      Renal Tubule, Pigmentation           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Ureter                                  |                                                                          |   1        |
      Inflammation, Acute                  |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Hemorrhage                           |                                                                          |      2  4.0|
      Inflammation, Acute                  |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  57                                                               
NTP Experiment-Test: 05041-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 11:52:17  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 6| 3| 7| 6| 6| 1| 2| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 7| 7| 7| 7| 0|             
                             DAY ON TEST   | 3| 9| 3| 2| 6| 0| 7| 4| 9| 7| 3| 3| 3| 3| 3| 3| 3| 0| 8| 7| 3| 3| 1| 3| 0|             
                                           | 0| 0| 4| 0| 5| 5| 7| 1| 1| 9| 0| 0| 0| 0| 0| 0| 0| 3| 3| 5| 0| 0| 6| 0| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    50MG/KG                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    LOW MALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +  +  +  +  +  +  +  +  +                       +  +  +        +     +|             
      Necrosis                             |                                                                         2|             
                                            __________________________________________________________________________|             
   Intestine Large                         |    +  A  +  +  +  +  +  A  +                       +  +  +        +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    +  A  M  +  +  +  +  A  +                       +  +  +        +     M|             
      Inflammation, Acute                  |                                                                          |             
      Parasite Protozoan                   |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +  A  +  +  +  +  +  A  +                       +  +  +        +     A|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +  A  +  +  +  +  +  A  +                       +  +  +        +     M|             
                                            __________________________________________________________________________|             
   Intestine Small                         |    +  A  +  +  +  +  +  A  +                       +  +  +        +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +  A  +  +  +  +  +  A  +                       +  +  +        +     A|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    +  A  +  +  +  +  +  A  +                       +  +  +        +     M|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +  A  +  +  +  +  +  A  +                       +  +  +        +     M|             
                                            __________________________________________________________________________|             
   Liver                                   |    +  +  +  +  +  +  +  +  +     +  +  +     +     +  +  +     +  +  +  +|             
      Angiectasis                          |                                                       1                  |             
      Basophilic Focus                     |          X                          X                    X               |             
      Basophilic Focus, Multiple           |                                                                X  X      |             
      Congestion                           |                                  2                                       |             
      Cytologic Alterations                |                                  X                                       |             
      Fibrosis, Focal                      |                                              2                           |             
      Hepatodiaphragmatic Nodule           |                                     X        X                 X         |             
      Hyperplasia, Focal                   |                                     2                                    |             
      Hyperplasia, Nodular                 |                                                    2                     |             
      Inflammation, Chronic                |                                                                          |             
      Necrosis, Focal                      |                                                    2                     |             
      Vacuolization Cytoplasmic            |                   4                    2     1                       1   |             
      Bile Duct, Hyperplasia               |    3  1  1  1  2  2              2  2  2     2     3  1  2     1  1      |             
      Centrilobular, Congestion            |                                     2                                    |             
      Centrilobular, Necrosis              |       3                                                                  |             
                                            __________________________________________________________________________|             
   Mesentery                               |                   +                    +                    +  +         |             
      Fat, Necrosis                        |                                                             2  2         |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +  +  +  +  +  +  +  +  +                       +  +  +        +     A|             
      Cyst                                 |                1                                      2                  |             
      Acinus, Atrophy, Diffuse             |                                                                          |             
      Acinus, Atrophy, Focal               |          1                                                               |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +  +  +  +  +  +  +  +  +                       +  +  +        +      |             
      Vacuolization Cytoplasmic            |                   2                                                      |             
                                            __________________________________________________________________________|             
   Stomach                                 |    +  +  +  +  +  +  +  +  +                       +  +  +        +     +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +  +  +  +  +  +  +  +  +                       +  +  +        +     +|             
      Edema                                |                   3                                                      |             
      Fungus                               |             X                                                            |             
      Ulcer                                |             2                                                            |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +  +  +  +  +  +  +  +  +                       +  +  +        +     +|             
      Atrophy                              |                                                                          |             
      Dilatation                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  58                                                               
NTP Experiment-Test: 05041-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 11:52:17  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 6| 3| 7| 6| 6| 1| 2| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 7| 7| 7| 7| 0|             
                             DAY ON TEST   | 3| 9| 3| 2| 6| 0| 7| 4| 9| 7| 3| 3| 3| 3| 3| 3| 3| 0| 8| 7| 3| 3| 1| 3| 0|             
                                           | 0| 0| 4| 0| 5| 5| 7| 1| 1| 9| 0| 0| 0| 0| 0| 0| 0| 3| 3| 5| 0| 0| 6| 0| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    50MG/KG                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    LOW MALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Edema                                |                   3                                                      |             
      Erosion                              |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                       +                  |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |    +  +  +  +  +  +  +  +  +        +              +  +  +        +     +|             
      Cardiomyopathy                       |    1  1  2     1  3  2     1        2                 1  1        2      |             
      Atrium, Thrombosis                   |                                                                          |             
      Epicardium, Fibrosis                 |                                                                          |             
      Epicardium, Inflammation, Chronic    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 2                                2  2                                    |             
      Hypertrophy, Focal                   |                                                 2                        |             
      Necrosis, Focal                      |                2                                                         |             
      Vacuolization Cytoplasmic, Focal     |                                                 2           2        2   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    1           1                             2                           |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +  +  +  +  +  +  +  +  +              +        +  +  +        +     A|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    +  +  +  +  +  +  +  +  M                       +  +  +        +     +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                                                                   2      |             
      Pars Distalis, Cyst                  |                                                                2         |             
      Pars Distalis, Hyperplasia           | 1           2                                               1            |             
      Pars Distalis, Inflammation, Chronic |                                                                          |             
      Pars Distalis, Thrombosis            |                                                          4               |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
      C-Cell, Hyperplasia                  |                                              1                           |             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |    +  +  +  +  +  +  +  +  +                       +  +  +        +     +|             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |    +  +  +  +  +  M  +  +  +                    +  M  +  M        M  +  M|             
                                            __________________________________________________________________________|             
   Prostate                                |    +  +  +  +  +  +  +  +  +                       +  +  +        +     +|             
      Hyperplasia                          |                                                                   1      |             
      Inflammation, Acute                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  59                                                               
NTP Experiment-Test: 05041-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 11:52:17  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 6| 3| 7| 6| 6| 1| 2| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 7| 7| 7| 7| 0|             
                             DAY ON TEST   | 3| 9| 3| 2| 6| 0| 7| 4| 9| 7| 3| 3| 3| 3| 3| 3| 3| 0| 8| 7| 3| 3| 1| 3| 0|             
                                           | 0| 0| 4| 0| 5| 5| 7| 1| 1| 9| 0| 0| 0| 0| 0| 0| 0| 3| 3| 5| 0| 0| 6| 0| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    50MG/KG                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    LOW MALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |    +  +  +  +  +  +  +  +  +                       +  +  +        +     +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Interstitial Cell, Hyperplasia       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +  +  +  +  +  +  +  +  +                       +  +  +        +     +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +  +  +  +  +  +  +  +  +                       +  +  +        +     +|             
      Mediastinal, Hemorrhage              |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |    +  +  +  M  +  +  +  +  +                       +  +  +        +     +|             
      Cyst                                 |                                                                          |             
      Hemorrhage                           |       2                                                                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |    +  +  +  +  +  +  +  +  +                       +  +  +        +     A|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +     +                 +  +  +        +  +  +|             
      Congestion                           |                                                                          |             
      Fibrosis, Focal                      |    2                                               2                 1   |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  |    +  +  +  M  +  +  +  +  +                       +  +  +        +     +|             
      Hemorrhage                           |                                                          3               |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    +  +  +  +  +  +  +  M  +                       M  +  +        +  +  +|             
      Dilatation                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    |    +  +  +  +  +  +  +  +  +                       +  M  +        +     +|             
      Cyst Epithelial Inclusion            |                                                                          |             
      Epithelium, Hyperplasia              |                2                                                         |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +  +  +  +  +  +  +  +  +                       +  +  +        +     +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                +                                                         |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +  +  +  +  +  +  +  +  +                       +  +  +        +     +|             
      Congestion                           |                         2                                                |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  |    +  +  +  +  +  +  +  +  +                       +  +  +              +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |          2              2  3                       3     2              3|             
      Fibrosis, Focal                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  60                                                               
NTP Experiment-Test: 05041-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 11:52:17  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 6| 3| 7| 6| 6| 1| 2| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 7| 7| 7| 7| 0|             
                             DAY ON TEST   | 3| 9| 3| 2| 6| 0| 7| 4| 9| 7| 3| 3| 3| 3| 3| 3| 3| 0| 8| 7| 3| 3| 1| 3| 0|             
                                           | 0| 0| 4| 0| 5| 5| 7| 1| 1| 9| 0| 0| 0| 0| 0| 0| 0| 3| 3| 5| 0| 0| 6| 0| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    50MG/KG                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    LOW MALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Foreign Body                         |          2              2                                                |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia                          |                                                                          |             
      Hyperplasia, Adenomatous             |                                           2  2                           |             
      Infiltration Cellular, Histiocyte    |                   2           1     1  2  1     1           1  1         |             
      Leukocytosis                         |                                                    4                     |             
      Necrosis, Multifocal                 |                         2                                                |             
      Thrombosis                           |                                        2           2                     |             
      Interstitium, Edema                  |                                                                          |             
      Interstitium, Inflammation, Chronic  |                                                                      2   |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Acute                           |                                                                          |             
      Sinus, Foreign Body                  |                                                                          |             
      Sinus, Fungus                        |    2  2                                                        2  3      |             
      Sinus, Hemorrhage                    |                         3                                                |             
      Sinus, Inflammation, Acute           |    2  2                                                        2  3      |             
                                            __________________________________________________________________________|             
   Trachea                                 |    +  +  +  +  +  +  +  +  +                       +  +  +        +     +|             
      Necrosis                             |                            3                                             |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |    +           +                          +        +                     |             
      Hemorrhage                           |                                           3                              |             
      Capsule, Lens, Cataract              |                                                                          |             
      Lens Capsule, Cataract               |                                           3        3                     |             
      Retina, Atrophy                      |    2           2                          3        3                     |             
      Sclera, Metaplasia, Osseous          |    2           2                          2                              |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                    +                     |             
      Inflammation, Chronic                |                                                    2                     |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                       3                  |             
      Hydronephrosis                       |                                                                          |             
      Inflammation, Suppurative            |             2                                                            |             
      Nephropathy                          | 1  2     1     1  1           1  1  2  1  2  1  1     1     1  1  1  1   |             
      Renal Tubule, Atrophy, Diffuse       |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    +  +  +  +  +  +  +  +  +                       +     +        +     +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  61                                                               
NTP Experiment-Test: 05041-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 11:52:17  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 7| 7| 6| 5| 5| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 4|             
                             DAY ON TEST   | 3| 1| 7| 2| 3| 3| 4| 6| 5| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 3| 3| 3| 1| 9|             
                                           | 0| 6| 6| 0| 0| 0| 1| 8| 0| 0| 0| 0| 0| 0| 2| 0| 0| 0| 0| 0| 0| 0| 0| 9| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    50MG/KG                                | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    LOW MALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +  +  +        +  +  +                 +                    +     +  +|             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         |    +  +  +        +  +  +                 +                    +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    +  +  +        +  +  +                 A                    +     +  +|             
      Inflammation, Acute                  |                                                                          |             
      Parasite Protozoan                   |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +  +  +        +  +  +                 +                    +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +  +  +        +  +  +                 +                    +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         |    +  +  +        +  +  +                 +                    +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +  +  +        +  +  +                 +                    +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    +  +  +        +  +  +                 +                    +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +  +  +        +  +  +                 +                    +     +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +     +  +     +  +|             
      Angiectasis                          |       2        1                                                         |             
      Basophilic Focus                     |          X                                X  X                           |             
      Basophilic Focus, Multiple           |             X                                   X              X         |             
      Congestion                           |    2                       1           2                                 |             
      Cytologic Alterations                |                                                       X     X  X         |             
      Fibrosis, Focal                      |                1              1        1                                 |             
      Hepatodiaphragmatic Nodule           |       X        X              X        X        X     X                  |             
      Hyperplasia, Focal                   |                                           2  2                           |             
      Hyperplasia, Nodular                 |                                                                          |             
      Inflammation, Chronic                | 1                                                                        |             
      Necrosis, Focal                      |                                                                          |             
      Vacuolization Cytoplasmic            | 2                                         2                          2   |             
      Bile Duct, Hyperplasia               |       2  1  2     2  2                 2     2        2        1         |             
      Centrilobular, Congestion            |                                                                          |             
      Centrilobular, Necrosis              |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |             +           +           +     +        +  +           +      |             
      Fat, Necrosis                        |             2                       2              2  2           2      |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +  +           +  +  +                 +                    +     +  +|             
      Cyst                                 |                                                                          |             
      Acinus, Atrophy, Diffuse             |       3                                                                  |             
      Acinus, Atrophy, Focal               |                                                                1         |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +  +  +        +  +  +                 +                    +     +  +|             
      Vacuolization Cytoplasmic            |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 |    +  +           +  +  +                 +  +        +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +  +           +  +  +                 +           +  +     +     +  +|             
      Edema                                |                                                                          |             
      Fungus                               |                                                                          |             
      Ulcer                                |                                                                      2   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +  +           +  +  +                 +  +        +  +     +  +  +  +|             
      Atrophy                              |                                                                      2   |             
      Dilatation                           |                                                                   2      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  62                                                               
NTP Experiment-Test: 05041-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 11:52:17  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 7| 7| 6| 5| 5| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 4|             
                             DAY ON TEST   | 3| 1| 7| 2| 3| 3| 4| 6| 5| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 3| 3| 3| 1| 9|             
                                           | 0| 6| 6| 0| 0| 0| 1| 8| 0| 0| 0| 0| 0| 0| 2| 0| 0| 0| 0| 0| 0| 0| 0| 9| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    50MG/KG                                | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    LOW MALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Edema                                |                                                                          |             
      Erosion                              |       2                                                                  |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |    +  +  +        +  +  +                 +                    +     +  +|             
      Cardiomyopathy                       |    2  2  1        1  1                                         2     2  1|             
      Atrium, Thrombosis                   |    2                                                                     |             
      Epicardium, Fibrosis                 |                                                                          |             
      Epicardium, Inflammation, Chronic    |                                           2                              |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Hypertrophy, Focal                   |                                                                          |             
      Necrosis, Focal                      |                                                                          |             
      Vacuolization Cytoplasmic, Focal     |                            2                                2     2      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |          1                    1  1                                2      |             
      Necrosis                             |       2                                                                  |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +  +           +  +  +                 +                    +     +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    +  +  +        +  +  +                 +                    +     +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |             2     2                                                      |             
      Pars Distalis, Cyst                  |                                                                2         |             
      Pars Distalis, Hyperplasia           |    2     2                                         1  1     1            |             
      Pars Distalis, Inflammation, Chronic |                2                                                         |             
      Pars Distalis, Thrombosis            |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                      2   |             
      C-Cell, Hyperplasia                  |                1                             1     1        1            |             
      Follicular Cell, Hyperplasia         |                                                                      3   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |    +  +  +        +  +  +                 +  +                 +     +  +|             
      Inflammation, Acute                  |                                              2                           |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |    +  +  +        +  +  +     +           M                    +     +  M|             
                                            __________________________________________________________________________|             
   Prostate                                |    +  +  +        +  +  +                 +     +              +     +  +|             
      Hyperplasia                          |    1                                            2                        |             
      Inflammation, Acute                  |       3                                                                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  63                                                               
NTP Experiment-Test: 05041-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 11:52:17  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 7| 7| 6| 5| 5| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 4|             
                             DAY ON TEST   | 3| 1| 7| 2| 3| 3| 4| 6| 5| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 3| 3| 3| 1| 9|             
                                           | 0| 6| 6| 0| 0| 0| 1| 8| 0| 0| 0| 0| 0| 0| 2| 0| 0| 0| 0| 0| 0| 0| 0| 9| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    50MG/KG                                | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    LOW MALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Pigmentation                         |                                                 2                        |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +        +     +                 +              +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                         2                                3               |             
      Interstitial Cell, Hyperplasia       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +  +  +        +  +  +                 +                    +     +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +  +  +        +  +  +                 +                    +     +  +|             
      Mediastinal, Hemorrhage              |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |    +  +  +        +  +  +                 +                    +     +  +|             
      Cyst                                 |    2                                                                     |             
      Hemorrhage                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |    +  +  +        +  +  +                 +                    +     +  +|             
                                            __________________________________________________________________________|             
   Spleen                                  |    +  +  +  +  +  +  +  +  +           +  +        +           +     +  +|             
      Congestion                           |                                        2                                 |             
      Fibrosis, Focal                      |                2                                                         |             
      Hematopoietic Cell Proliferation     |                   2                                                      |             
      Hemorrhage                           |    2                                                                     |             
      Pigmentation                         |                      1                                                   |             
                                            __________________________________________________________________________|             
   Thymus                                  |    +  +  +        +  +  +                 +                    +     +  +|             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    +  +  +        M  M  +                 +                 +  M     +  +|             
      Dilatation                           |                                                                         2|             
                                            __________________________________________________________________________|             
   Skin                                    |    +  +  +        +  +  +  +              +                    +     +  +|             
      Cyst Epithelial Inclusion            |                                                                      2   |             
      Epithelium, Hyperplasia              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +  +  +        +  +  +                 +                    +     +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |       +  +        +  +  +                 +                    +     +  +|             
      Congestion                           |                                                                          |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                         +                                                |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  |    +  +  +        +  +  +                 +                    +     +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           | 1        2                                                               |             
      Fibrosis, Focal                      |                                     1                                    |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  64                                                               
NTP Experiment-Test: 05041-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 11:52:17  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 7| 7| 6| 5| 5| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 4|             
                             DAY ON TEST   | 3| 1| 7| 2| 3| 3| 4| 6| 5| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 3| 3| 3| 1| 9|             
                                           | 0| 6| 6| 0| 0| 0| 1| 8| 0| 0| 0| 0| 0| 0| 2| 0| 0| 0| 0| 0| 0| 0| 0| 9| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    50MG/KG                                | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    LOW MALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Foreign Body                         |                                                                          |             
      Hemorrhage                           |                         4                                                |             
      Hyperplasia                          |                                                          2               |             
      Hyperplasia, Adenomatous             |                               2              1                           |             
      Infiltration Cellular, Histiocyte    | 1              1                 1  1  1        1  1        1     1      |             
      Leukocytosis                         |                                                                          |             
      Necrosis, Multifocal                 |                                                                          |             
      Thrombosis                           |                   2                                                      |             
      Interstitium, Edema                  |                   2                                                      |             
      Interstitium, Inflammation, Chronic  |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Acute                           |                         2                                                |             
      Sinus, Foreign Body                  |          2                                                               |             
      Sinus, Fungus                        |                                                                   2      |             
      Sinus, Hemorrhage                    |                                                                          |             
      Sinus, Inflammation, Acute           |    2     2           2                                            2      |             
                                            __________________________________________________________________________|             
   Trachea                                 |    +  +  +        +  +  +                 +                    +     +  +|             
      Necrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                         +                    +  +  +                     |             
      Hemorrhage                           |                                                                          |             
      Capsule, Lens, Cataract              |                                              3                           |             
      Lens Capsule, Cataract               |                                                 3  2                     |             
      Retina, Atrophy                      |                         3                    3  3  2                     |             
      Sclera, Metaplasia, Osseous          |                                                 2                        |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                   +                                                      |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                         2|             
      Hydronephrosis                       |                         4                                                |             
      Inflammation, Suppurative            |                                                                          |             
      Nephropathy                          | 1     1  2  1        1     1  1  1  1  1     1  1     1  2     1  3     1|             
      Renal Tubule, Atrophy, Diffuse       |                                                                      3   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    +  +  +        +  +  +                 +                    +     +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  65                                                               
NTP Experiment-Test: 05041-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 11:52:17  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 4| 7| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 2| 3| 9| 5| 3| 3| 3| 3| 3| 1|                                            |            |
                                           | 3| 0| 8| 1| 0| 1| 1| 1| 1| 4|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    50MG/KG                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
    LOW MALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +     +  +                 +                                             |  28        |
      Necrosis                             |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +     +  +        +        +                                             |  27        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +     +  +        +        +                                             |  24        |
      Inflammation, Acute                  |                   2                                                      |      1  2.0|
      Parasite Protozoan                   |          X                                                               |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +     +  +                 +                                             |  25        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +     +  +                 +                                             |  25        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +     +  +                 A                                             |  25        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +     +  +                 A                                             |  24        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +     +  +                 A                                             |  24        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +     A  +                 A                                             |  23        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +     +  +     +     +     +                                             |  47        |
      Angiectasis                          |                                                                          |      3  1.3|
      Basophilic Focus                     |       X                                                                  |      7     |
      Basophilic Focus, Multiple           |                                                                          |      5     |
      Congestion                           |                                                                          |      4  1.8|
      Cytologic Alterations                |                                                                          |      4     |
      Fibrosis, Focal                      |                                                                          |      4  1.3|
      Hepatodiaphragmatic Nodule           |                                                                          |      9     |
      Hyperplasia, Focal                   |                      2                                                   |      4  2.0|
      Hyperplasia, Nodular                 |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                                                          |      1  1.0|
      Necrosis, Focal                      |                                                                          |      1  2.0|
      Vacuolization Cytoplasmic            |                                                                          |      7  2.0|
      Bile Duct, Hyperplasia               |          1     2     2     2                                             |     28  1.8|
      Centrilobular, Congestion            |                                                                          |      1  2.0|
      Centrilobular, Necrosis              |       4                                                                  |      2  3.5|
                                            __________________________________________________________________________|____________|
   Mesentery                               |    +     +                 +                                             |  14        |
      Fat, Necrosis                        |    2     2                 2                                             |     10  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +     +  +                 +                                             |  26        |
      Cyst                                 |                                                                          |      2  1.5|
      Acinus, Atrophy, Diffuse             |                                                                          |      1  3.0|
      Acinus, Atrophy, Focal               |                                                                          |      2  1.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +     +  +                 +                                             |  27        |
      Vacuolization Cytoplasmic            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +     +  +                 +                                             |  31        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +     +  +                 +                                             |  29        |
      Edema                                |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  66                                                               
NTP Experiment-Test: 05041-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 11:52:17  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 4| 7| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 2| 3| 9| 5| 3| 3| 3| 3| 3| 1|                                            |            |
                                           | 3| 0| 8| 1| 0| 1| 1| 1| 1| 4|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    50MG/KG                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
    LOW MALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Fungus                               |                                                                          |      1     |
      Ulcer                                |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +     +  +                 +                                             |  31        |
      Atrophy                              |                                                                          |      1  2.0|
      Dilatation                           |                                                                          |      1  2.0|
      Edema                                |                                                                          |      1  3.0|
      Erosion                              |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +     +  +                 +                                             |  29        |
      Cardiomyopathy                       |       2  1                 1                                             |     22  1.5|
      Atrium, Thrombosis                   |                                                                          |      1  2.0|
      Epicardium, Fibrosis                 |       2                                                                  |      1  2.0|
      Epicardium, Inflammation, Chronic    |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperplasia                          |                                                                          |      3  2.0|
      Hypertrophy, Focal                   |                                                                          |      1  2.0|
      Necrosis, Focal                      |                                                                          |      1  2.0|
      Vacuolization Cytoplasmic, Focal     |                   2  1                                                   |      8  1.9|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Hyperplasia                          | 2                       2                                                |      9  1.4|
      Necrosis                             |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +     +  +                 +                                             |  27        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +     M  +                 +                                             |  26        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Pars Distalis, Angiectasis           |                                                                          |      3  2.0|
      Pars Distalis, Cyst                  |                                                                          |      2  2.0|
      Pars Distalis, Hyperplasia           |    2  2           1                                                      |     11  1.5|
      Pars Distalis, Inflammation, Chronic |                                                                          |      1  2.0|
      Pars Distalis, Thrombosis            |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Fibrosis                             |                                                                          |      1  2.0|
      C-Cell, Hyperplasia                  |             1                                                            |      6  1.0|
      Follicular Cell, Hyperplasia         |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  67                                                               
NTP Experiment-Test: 05041-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 11:52:17  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 4| 7| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 2| 3| 9| 5| 3| 3| 3| 3| 3| 1|                                            |            |
                                           | 3| 0| 8| 1| 0| 1| 1| 1| 1| 4|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    50MG/KG                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
    LOW MALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +     +  +                 +                                             |  29        |
      Inflammation, Acute                  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +     +  M                 +                                             |  23        |
                                            __________________________________________________________________________|____________|
   Prostate                                | +     +  +                 +                                             |  29        |
      Hyperplasia                          |                                                                          |      3  1.3|
      Inflammation, Acute                  |                                                                          |      1  3.0|
      Pigmentation                         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +     +  +                 +                                             |  30        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Atrophy                              |          2                                                               |      3  2.3|
      Interstitial Cell, Hyperplasia       |       2                                                                  |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +     +  +                 +                                             |  28        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +     +  +           +     +                                             |  29        |
      Mediastinal, Hemorrhage              |       2                                                                  |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +     +  +           +     +                                             |  28        |
      Cyst                                 |                            2                                             |      2  2.0|
      Hemorrhage                           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +     +  +           +     +                                             |  28        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +     +     +     +                                             |  39        |
      Congestion                           |                                                                          |      1  2.0|
      Fibrosis, Focal                      |       1                                                                  |      5  1.6|
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
      Hemorrhage                           |                                                                          |      1  2.0|
      Pigmentation                         |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +     +  +           +     +                                             |  28        |
      Hemorrhage                           |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +     +  +                 +                                             |  25        |
      Dilatation                           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +     +  +           +     +                                             |  29        |
      Cyst Epithelial Inclusion            |                                                                          |      1  2.0|
      Epithelium, Hyperplasia              |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +     +  +                 +                                             |  28        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  68                                                               
NTP Experiment-Test: 05041-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 11:52:17  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 4| 7| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 2| 3| 9| 5| 3| 3| 3| 3| 3| 1|                                            |            |
                                           | 3| 0| 8| 1| 0| 1| 1| 1| 1| 4|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    50MG/KG                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
    LOW MALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +     +  +                 +                                             |  27        |
      Congestion                           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +     +  +                 +                                             |  27        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Congestion                           |       3                    2                                             |     10  2.3|
      Fibrosis, Focal                      |                   1                                                      |      2  1.0|
      Foreign Body                         |                   1                                                      |      3  1.7|
      Hemorrhage                           |    2                                                                     |      2  3.0|
      Hyperplasia                          |                                                                          |      1  2.0|
      Hyperplasia, Adenomatous             |                                                                          |      4  1.8|
      Infiltration Cellular, Histiocyte    |    1                                                                     |     18  1.1|
      Leukocytosis                         |                                                                          |      1  4.0|
      Necrosis, Multifocal                 |                                                                          |      1  2.0|
      Thrombosis                           |                                                                          |      3  2.0|
      Interstitium, Edema                  |                                                                          |      1  2.0|
      Interstitium, Inflammation, Chronic  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Acute                           |                                                                          |      1  2.0|
      Sinus, Foreign Body                  |                            2                                             |      2  2.0|
      Sinus, Fungus                        |             2        2                                                   |      7  2.1|
      Sinus, Hemorrhage                    |                                                                          |      1  3.0|
      Sinus, Inflammation, Acute           |             2        2     1                                             |     11  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +     +  +                 +                                             |  28        |
      Necrosis                             |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   8        |
      Hemorrhage                           |                                                                          |      1  3.0|
      Capsule, Lens, Cataract              |                                                                          |      1  3.0|
      Lens Capsule, Cataract               |                                                                          |      4  2.8|
      Retina, Atrophy                      |                                                                          |      8  2.6|
      Sclera, Metaplasia, Osseous          |                                                                          |      4  2.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  69                                                               
NTP Experiment-Test: 05041-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 11:52:17  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 4| 7| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 2| 3| 9| 5| 3| 3| 3| 3| 3| 1|                                            |            |
                                           | 3| 0| 8| 1| 0| 1| 1| 1| 1| 4|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    50MG/KG                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
    LOW MALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Chronic                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cyst                                 |                                                                          |      2  2.5|
      Hydronephrosis                       |                                                                          |      1  4.0|
      Inflammation, Suppurative            |                                                                          |      1  2.0|
      Nephropathy                          | 2  2        1  1  2     1                                                |     40  1.3|
      Renal Tubule, Atrophy, Diffuse       |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +     +  +                 +                                             |  27        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  70                                                               
NTP Experiment-Test: 05041-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 11:52:17  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 7| 1| 7| 7| 7| 5| 4| 7| 7| 7| 7| 7| 7| 7| 6| 6| 3| 7| 7| 7| 6| 6|             
                             DAY ON TEST   | 3| 3| 5| 3| 7| 3| 3| 1| 7| 3| 3| 3| 3| 0| 1| 3| 3| 7| 0| 0| 3| 3| 3| 9| 9|             
                                           | 1| 1| 4| 1| 6| 1| 1| 3| 0| 1| 1| 1| 1| 3| 1| 1| 1| 0| 4| 5| 1| 1| 1| 8| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    100MG/KG                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    HIGHMALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |             3                                                            |             
      Muscularis, Regeneration             |                      2                                                   |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Circumanal Gland, Hyperplasia        |                                     2                       1            |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Parasite Protozoan                   |                            X                                             |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  M  A  +  +  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     |                            X                 X                           |             
      Basophilic Focus, Multiple           |       X  X        X     X        X              X     X                  |             
      Congestion                           |                      2              1                                    |             
      Cytologic Alterations                |                                                                          |             
      Cytologic Alterations, Multiple      |                   X                                                      |             
      Fibrosis, Focal                      |             1                                                            |             
      Hepatodiaphragmatic Nodule           |    X                    X                 X                              |             
      Inflammation, Chronic                |          1                    1                                          |             
      Vacuolization Cytoplasmic            |                2                                            1  1        3|             
      Bile Duct, Hyperplasia               | 2  2  1  2     2  2  1  2  1  2  2  2  2     2  2  1  1     1  2  1  2   |             
      Centrilobular, Necrosis              |                                                                   2      |             
      Centrilobular, Vacuolization         |                                                                          |             
          Cytoplasmic                      |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |          +              +                 +  +  +                    +   |             
      Artery, Inflammation, Multifocal     |                                                                          |             
      Fat, Necrosis                        |          3                                3  2  3                    2   |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy, Focal               |                   2        1  2                 2           2     1  1   |             
      Artery, Inflammation, Chronic        |                                                                          |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                  +                                       |             
      Developmental Malformation           |                                  X                                       |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                 1                        |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |                                        1                                 |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  71                                                               
NTP Experiment-Test: 05041-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 11:52:17  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 7| 1| 7| 7| 7| 5| 4| 7| 7| 7| 7| 7| 7| 7| 6| 6| 3| 7| 7| 7| 6| 6|             
                             DAY ON TEST   | 3| 3| 5| 3| 7| 3| 3| 1| 7| 3| 3| 3| 3| 0| 1| 3| 3| 7| 0| 0| 3| 3| 3| 9| 9|             
                                           | 1| 1| 4| 1| 6| 1| 1| 3| 0| 1| 1| 1| 1| 3| 1| 1| 1| 0| 4| 5| 1| 1| 1| 8| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    100MG/KG                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    HIGHMALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Peridontal Tissue, Inflammation,     |                                                                          |             
           Acute                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1  2  2  2     1  2  2  2  1  2  1  2  2  2  2  1     1     2  2  1  3  1|             
      Atrium, Thrombosis                   |                                                                   3  3   |             
      Endocardium, Fibrosis                |                                                                          |             
      Epicardium, Inflammation, Chronic    |                                                 2                        |             
      Myocardium, Inflammation, Acute      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia                          |                   2                                                      |             
      Necrosis, Focal                      |                                                                          |             
      Vacuolization Cytoplasmic, Focal     |                                                             1           2|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Hyperplasia                          | 2                       1     1  1  1                             2      |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                   1                                                      |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                               2        2     2           1               |             
      Pars Distalis, Cyst                  |                                              2                           |             
      Pars Distalis, Hyperplasia           |                1           2  1  2              2           1            |             
      Pars Distalis, Vacuolization         |                                                                          |             
          Cytoplasmic                      |                                                                   2      |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                          1               |             
      C-Cell, Hyperplasia                  |    1     1                                                               |             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                 2                        |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  72                                                               
NTP Experiment-Test: 05041-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 11:52:17  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 7| 1| 7| 7| 7| 5| 4| 7| 7| 7| 7| 7| 7| 7| 6| 6| 3| 7| 7| 7| 6| 6|             
                             DAY ON TEST   | 3| 3| 5| 3| 7| 3| 3| 1| 7| 3| 3| 3| 3| 0| 1| 3| 3| 7| 0| 0| 3| 3| 3| 9| 9|             
                                           | 1| 1| 4| 1| 6| 1| 1| 3| 0| 1| 1| 1| 1| 3| 1| 1| 1| 0| 4| 5| 1| 1| 1| 8| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    100MG/KG                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    HIGHMALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Hyperplasia                          |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |                         1                                                |             
      Metaplasia, Osseous                  |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                              2                           |             
      Hyperplasia                          |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |                                                             2            |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                      2   |             
      Interstitial Cell, Hyperplasia       |                      1              1                    2               |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                           3                              |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mediastinal, Hyperplasia             |                                              2                           |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  M  +  +  M  M  +  +  +  M  +  M  +  +  +  +  +|             
      Hemorrhage                           |                                                 2                    2   |             
      Hyperplasia, Lymphoid                |                                                                2         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Fibrosis, Focal                      |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                   2      |             
      Necrosis                             |                                        2                                 |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  M  +  +  M  M  +  +  +|             
      Congestion                           |                                                                          |             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  M  +  M  M  +  +  M  M  +  +  +  +  +  +  M  +|             
      Dilatation                           |                                                                          |             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            | 3              2                                                         |             
      Subcutaneous Tissue, Edema           |                                                                      2   |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Acute                           |                                                                          |             
      Subcutaneous Tissue, Thrombosis      |                                                             3            |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  73                                                               
NTP Experiment-Test: 05041-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 11:52:17  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 7| 1| 7| 7| 7| 5| 4| 7| 7| 7| 7| 7| 7| 7| 6| 6| 3| 7| 7| 7| 6| 6|             
                             DAY ON TEST   | 3| 3| 5| 3| 7| 3| 3| 1| 7| 3| 3| 3| 3| 0| 1| 3| 3| 7| 0| 0| 3| 3| 3| 9| 9|             
                                           | 1| 1| 4| 1| 6| 1| 1| 3| 0| 1| 1| 1| 1| 3| 1| 1| 1| 0| 4| 5| 1| 1| 1| 8| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    100MG/KG                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    HIGHMALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                         +                    +                           |             
      Cyst                                 |                                              3                           |             
      Inflammation, Chronic                |                                              3                           |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cerebrum, Inflammation, Chronic      |                                                                          |             
      Meninges, Hemorrhage                 |                                                                          |             
      Meninges, Inflammation, Chronic      |                                                                          |             
      Thalamus, Compression                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Necrosis                             |       3                                                                  |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |       3     2              2                          2  3               |             
      Foreign Body                         |             2     2              2                                       |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Adenomatous             |                                                                1         |             
      Infiltration Cellular, Histiocyte    |                   1        1                                   1  1      |             
      Inflammation, Granulomatous          |                                  2                                       |             
      Necrosis, Focal                      |             2                                                            |             
      Necrosis, Multifocal                 |                            1                             2               |             
      Alveolar Epithelium, Hyperplasia     |                      3                                                   |             
      Alveolus, Fibrosis, Focal            |                                                                          |             
      Interstitium, Inflammation, Chronic  |                   1                                                      |             
      Mediastinum, Hemorrhage              | 3                                                                        |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Acute                           |                                                                          |             
      Olfactory Epithelium, Inflammation,  |                                                                          |             
           Chronic                         |                               2                                          |             
      Sinus, Foreign Body                  |                                           2                              |             
      Sinus, Fungus                        |                               2                                2         |             
      Sinus, Inflammation, Acute           |                2                          2                    2  2      |             
      Turbinate, Inflammation, Acute       |                                                                          |             
      Turbinate, Inflammation, Chronic     |                         1                             2                  |             
      Turbinate, Metaplasia, Squamous      |                                                       2                  |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                      2                                                   |             
      Necrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  74                                                               
NTP Experiment-Test: 05041-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 11:52:17  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 7| 1| 7| 7| 7| 5| 4| 7| 7| 7| 7| 7| 7| 7| 6| 6| 3| 7| 7| 7| 6| 6|             
                             DAY ON TEST   | 3| 3| 5| 3| 7| 3| 3| 1| 7| 3| 3| 3| 3| 0| 1| 3| 3| 7| 0| 0| 3| 3| 3| 9| 9|             
                                           | 1| 1| 4| 1| 6| 1| 1| 3| 0| 1| 1| 1| 1| 3| 1| 1| 1| 0| 4| 5| 1| 1| 1| 8| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    100MG/KG                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    HIGHMALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |          +        +                                                     +|             
      Lens Capsule, Cataract               |                   2                                                      |             
      Retina, Atrophy                      |          3        2                                                      |             
      Sclera, Metaplasia, Osseous          |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |          +                                                              +|             
      Inflammation, Chronic, Focal         |          1                                                               |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Congestion                           |                      2                                                   |             
      Cyst                                 |                                                 1                        |             
      Mineralization                       |                                                                          |             
      Nephropathy                          |       1  1     1  2           1  1  1     1  1  1           2  1         |             
      Pelvis, Mineralization               |                                                                         1|             
      Renal Tubule, Pigmentation           |                         2                                                |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  75                                                               
NTP Experiment-Test: 05041-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 11:52:17  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 0| 7| 7| 6| 6| 5| 7| 7| 7| 6| 1| 7| 6| 5| 7| 0| 7| 7| 7| 0| 7|             
                             DAY ON TEST   | 3| 3| 3| 2| 9| 3| 1| 6| 0| 1| 3| 3| 3| 7| 8| 3| 3| 3| 3| 6| 2| 3| 3| 8| 3|             
                                           | 1| 1| 1| 5| 6| 1| 9| 2| 3| 5| 1| 1| 1| 9| 5| 1| 9| 3| 1| 8| 3| 1| 1| 2| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    100MG/KG                               | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    HIGHMALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                                                                          |             
      Muscularis, Regeneration             |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  M  +  +  +  M  +|             
      Circumanal Gland, Hyperplasia        |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  M  +  +  +  +  +  +  +  +  A  +  +  +  +  +  M  +  +  +  M  +|             
      Parasite Protozoan                   |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  A  A  +  +  +  +  A  +  +  +  +  +  M  +  +  +  M  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  M  +  +  A  A  +  +  +  +  A  +  +  +  +  +  M  +  +  +  M  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  +  +  +  M  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  A  A  +  +  +  +  A  +  +  +  +  +  M  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  M  +  +  A  A  +  +  +  +  A  +  +  +  +  +  M  +  +  +  M  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  M  +  +  A  A  +  +  +  +  A  +  +  +  +  +  M  +  +  +  M  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                2         |             
      Basophilic Focus                     |                                                                          |             
      Basophilic Focus, Multiple           |                X                    X        X     X  X           X     X|             
      Congestion                           |                   2                                                      |             
      Cytologic Alterations                |                                                                          |             
      Cytologic Alterations, Multiple      |                                                                          |             
      Fibrosis, Focal                      |                                                             2     2      |             
      Hepatodiaphragmatic Nodule           |                                                             X     X      |             
      Inflammation, Chronic                |                1                                                         |             
      Vacuolization Cytoplasmic            |                                                                          |             
      Bile Duct, Hyperplasia               | 1  1  2        2     2  2  2  2  2  2        2  2  1  2     2     2     1|             
      Centrilobular, Necrosis              |             2                    3                                       |             
      Centrilobular, Vacuolization         |                                                                          |             
          Cytoplasmic                      |                                              2           1               |             
                                            __________________________________________________________________________|             
   Mesentery                               |                               +              +        +                  |             
      Artery, Inflammation, Multifocal     |                                                                          |             
      Fat, Necrosis                        |                               2              2        3                  |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy, Focal               |    2                 2  1  2                                1  1        2|             
      Artery, Inflammation, Chronic        |                   2                                                      |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                                                          |             
      Developmental Malformation           |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                      3                                                   |             
      Inflammation, Chronic                |                                                                          |             
      Ulcer                                |                            2                                             |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  76                                                               
NTP Experiment-Test: 05041-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 11:52:17  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 0| 7| 7| 6| 6| 5| 7| 7| 7| 6| 1| 7| 6| 5| 7| 0| 7| 7| 7| 0| 7|             
                             DAY ON TEST   | 3| 3| 3| 2| 9| 3| 1| 6| 0| 1| 3| 3| 3| 7| 8| 3| 3| 3| 3| 6| 2| 3| 3| 8| 3|             
                                           | 1| 1| 1| 5| 6| 1| 9| 2| 3| 5| 1| 1| 1| 9| 5| 1| 9| 3| 1| 8| 3| 1| 1| 2| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    100MG/KG                               | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    HIGHMALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |    +                                                                     |             
      Peridontal Tissue, Inflammation,     |                                                                          |             
           Acute                           |    2                                                                     |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1  1  1        1  1  2  1     1  2           1  1     1        2     1   |             
      Atrium, Thrombosis                   |                                                                          |             
      Endocardium, Fibrosis                |                                                             2            |             
      Epicardium, Inflammation, Chronic    |                                                          2               |             
      Myocardium, Inflammation, Acute      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                   2      |             
      Hematopoietic Cell Proliferation     |                                  1                                       |             
      Hyperplasia                          | 2                                                     2                  |             
      Necrosis, Focal                      |          2                                                               |             
      Vacuolization Cytoplasmic, Focal     |       3                                                                  |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |       2           3     1           1                       1           1|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  M  +  +  M  +  M  +  +  M  +  +  M  M  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                                     1                                    |             
      Pars Distalis, Cyst                  |       2                                                                  |             
      Pars Distalis, Hyperplasia           |       2                 1        2                                       |             
      Pars Distalis, Vacuolization         |                                                                          |             
          Cytoplasmic                      |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                              2                           |             
      C-Cell, Hyperplasia                  |                                  1                                1      |             
      Follicular Cell, Hyperplasia         |                   2                                                      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  A  +  +  +  +  +  M  +  +  +  +  +  M  +  M  +  M  +|             
      Dilatation                           |                         2                                                |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  77                                                               
NTP Experiment-Test: 05041-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 11:52:17  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 0| 7| 7| 6| 6| 5| 7| 7| 7| 6| 1| 7| 6| 5| 7| 0| 7| 7| 7| 0| 7|             
                             DAY ON TEST   | 3| 3| 3| 2| 9| 3| 1| 6| 0| 1| 3| 3| 3| 7| 8| 3| 3| 3| 3| 6| 2| 3| 3| 8| 3|             
                                           | 1| 1| 1| 5| 6| 1| 9| 2| 3| 5| 1| 1| 1| 9| 5| 1| 9| 3| 1| 8| 3| 1| 1| 2| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    100MG/KG                               | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    HIGHMALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Hyperplasia                          |                         3                                                |             
      Inflammation, Acute                  |                                              2                          3|             
      Inflammation, Chronic                |                                                                          |             
      Metaplasia, Osseous                  |                         2                                                |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Hyperplasia                          |                                                                   2      |             
      Inflammation, Acute                  |                   2                                                      |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  M  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                3                                                         |             
      Interstitial Cell, Hyperplasia       |                      2                                                   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mediastinal, Hyperplasia             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |             2                                                            |             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                          2               |             
      Fibrosis, Focal                      |                   2                                            3         |             
      Hematopoietic Cell Proliferation     |                                  2                                       |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  +  +  +  +  +  +  +  +  +  M  +  A  +  +  M  +  +  +  +  M  +  +  +|             
      Congestion                           |                                                                          |             
      Hemorrhage                           |                                           2              2               |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  M  M  +  +  M  M  +  M  +  M  +  M  +  +  M  M  +  +  +  +  M|             
      Dilatation                           |                                                                          |             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                                                          |             
      Subcutaneous Tissue, Edema           |                                                                          |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Acute                           |                                                                         2|             
      Subcutaneous Tissue, Thrombosis      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  78                                                               
NTP Experiment-Test: 05041-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 11:52:17  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 0| 7| 7| 6| 6| 5| 7| 7| 7| 6| 1| 7| 6| 5| 7| 0| 7| 7| 7| 0| 7|             
                             DAY ON TEST   | 3| 3| 3| 2| 9| 3| 1| 6| 0| 1| 3| 3| 3| 7| 8| 3| 3| 3| 3| 6| 2| 3| 3| 8| 3|             
                                           | 1| 1| 1| 5| 6| 1| 9| 2| 3| 5| 1| 1| 1| 9| 5| 1| 9| 3| 1| 8| 3| 1| 1| 2| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    100MG/KG                               | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    HIGHMALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Cyst                                 |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cerebrum, Inflammation, Chronic      |                                                                          |             
      Meninges, Hemorrhage                 |                                                    1                     |             
      Meninges, Inflammation, Chronic      |                                                                          |             
      Thalamus, Compression                |                                                    3                     |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |       2                 2                 4        2     3           4   |             
      Foreign Body                         |             2                             2                          2   |             
      Hemorrhage                           |             2                                                            |             
      Hyperplasia, Adenomatous             |                                                                          |             
      Infiltration Cellular, Histiocyte    |                   1           2     1              1  1                  |             
      Inflammation, Granulomatous          |                                                                          |             
      Necrosis, Focal                      |                                                                          |             
      Necrosis, Multifocal                 |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Alveolus, Fibrosis, Focal            |                                                                          |             
      Interstitium, Inflammation, Chronic  |                   2                                                      |             
      Mediastinum, Hemorrhage              |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Acute                           |          2                                                               |             
      Olfactory Epithelium, Inflammation,  |                                                                          |             
           Chronic                         |                                                                          |             
      Sinus, Foreign Body                  |                                                                          |             
      Sinus, Fungus                        |                      2        2                             2            |             
      Sinus, Inflammation, Acute           |                   2  2        2  2                          2            |             
      Turbinate, Inflammation, Acute       |       2                                                                  |             
      Turbinate, Inflammation, Chronic     |                                  2                                       |             
      Turbinate, Metaplasia, Squamous      |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Necrosis                             |             3                                            3           3   |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  79                                                               
NTP Experiment-Test: 05041-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 11:52:17  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 0| 7| 7| 6| 6| 5| 7| 7| 7| 6| 1| 7| 6| 5| 7| 0| 7| 7| 7| 0| 7|             
                             DAY ON TEST   | 3| 3| 3| 2| 9| 3| 1| 6| 0| 1| 3| 3| 3| 7| 8| 3| 3| 3| 3| 6| 2| 3| 3| 8| 3|             
                                           | 1| 1| 1| 5| 6| 1| 9| 2| 3| 5| 1| 1| 1| 9| 5| 1| 9| 3| 1| 8| 3| 1| 1| 2| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    100MG/KG                               | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    HIGHMALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |    +              +                                +                     |             
      Lens Capsule, Cataract               |                                                                          |             
      Retina, Atrophy                      |    3                                               1                     |             
      Sclera, Metaplasia, Osseous          |    2              2                                                      |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
      Inflammation, Chronic, Focal         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Cyst                                 |                                                                          |             
      Mineralization                       |          1                                                               |             
      Nephropathy                          | 1  2  1        2  4     1     1     1        1     1        2  2         |             
      Pelvis, Mineralization               |                                                                          |             
      Renal Tubule, Pigmentation           |                                  2                                       |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                            1                                             |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  80                                                               
NTP Experiment-Test: 05041-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 11:52:17  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 4| 2|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 1| 6| 0|                                            |            |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 3| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    100MG/KG                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
    HIGHMALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Inflammation, Acute                  |                                                                          |      1  3.0|
      Muscularis, Regeneration             |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  A                                             |  54        |
      Circumanal Gland, Hyperplasia        |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  A                                             |  53        |
      Parasite Protozoan                   |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  A                                             |  51        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  A                                             |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  A                                             |  54        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  A                                             |  53        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  A                                             |  51        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  A                                             |  51        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Angiectasis                          |                                                                          |      1  2.0|
      Basophilic Focus                     |                                                                          |      2     |
      Basophilic Focus, Multiple           |       X  X     X  X     X                                                |     19     |
      Congestion                           |                                                                          |      3  1.7|
      Cytologic Alterations                |                X                                                         |      1     |
      Cytologic Alterations, Multiple      |                                                                          |      1     |
      Fibrosis, Focal                      |                      2                                                   |      4  1.8|
      Hepatodiaphragmatic Nodule           |                      X                                                   |      6     |
      Inflammation, Chronic                |          1                                                               |      4  1.0|
      Vacuolization Cytoplasmic            |                                                                          |      4  1.8|
      Bile Duct, Hyperplasia               | 1  1     1  1  2  2  2  2                                                |     46  1.7|
      Centrilobular, Necrosis              |                                                                          |      3  2.3|
      Centrilobular, Vacuolization         |                                                                          |            |
          Cytoplasmic                      |                         2                                                |      3  1.7|
                                            __________________________________________________________________________|____________|
   Mesentery                               |       +        +        +                                                |  12        |
      Artery, Inflammation, Multifocal     |                         2                                                |      1  2.0|
      Fat, Necrosis                        |       3        2        3                                                |     11  2.5|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Acinus, Atrophy, Focal               |       1           2  2                                                   |     17  1.6|
      Artery, Inflammation, Chronic        |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pharynx                                 |                                                                          |   1        |
      Developmental Malformation           |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Inflammation, Chronic                |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +                                             |  59        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  81                                                               
NTP Experiment-Test: 05041-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 11:52:17  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 4| 2|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 1| 6| 0|                                            |            |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 3| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    100MG/KG                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
    HIGHMALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  M  +  +  +                                             |  58        |
      Inflammation, Acute                  |                                                                          |      1  3.0|
      Inflammation, Chronic                |                                                                          |      1  1.0|
      Ulcer                                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
      Peridontal Tissue, Inflammation,     |                                                                          |            |
           Acute                           |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Cardiomyopathy                       | 2  1  1     2     2     2  2                                             |     43  1.5|
      Atrium, Thrombosis                   |                                                                          |      2  3.0|
      Endocardium, Fibrosis                |                                                                          |      1  2.0|
      Epicardium, Inflammation, Chronic    |                                                                          |      2  2.0|
      Myocardium, Inflammation, Acute      |          2                                                               |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Angiectasis                          |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     |                                                                          |      1  1.0|
      Hyperplasia                          | 1                                                                        |      4  1.8|
      Necrosis, Focal                      |                                                                          |      1  2.0|
      Vacuolization Cytoplasmic, Focal     |                                                                          |      3  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  M  +  +                                             |  58        |
      Hyperplasia                          |       1        2                                                         |     14  1.4|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperplasia                          |          1     2                                                         |      3  1.3|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  M                                             |  51        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Pars Distalis, Angiectasis           |                                                                          |      5  1.6|
      Pars Distalis, Cyst                  |                                                                          |      2  2.0|
      Pars Distalis, Hyperplasia           |       1           2                                                      |     11  1.5|
      Pars Distalis, Vacuolization         |                                                                          |            |
          Cytoplasmic                      |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Cyst                                 |                                                                          |      2  1.5|
      C-Cell, Hyperplasia                  |                                                                          |      4  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  82                                                               
NTP Experiment-Test: 05041-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 11:52:17  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 4| 2|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 1| 6| 0|                                            |            |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 3| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    100MG/KG                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
    HIGHMALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Follicular Cell, Hyperplasia         |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Inflammation, Chronic                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  M  M  +  +                                             |  51        |
      Dilatation                           |                                                                          |      1  2.0|
      Hyperplasia                          |                                                                          |      1  3.0|
      Inflammation, Acute                  |                2                                                         |      3  2.3|
      Inflammation, Chronic                |                                                                          |      1  1.0|
      Metaplasia, Osseous                  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  A                                             |  58        |
      Hemorrhage                           |                                                                          |      1  2.0|
      Hyperplasia                          |                                                                          |      1  2.0|
      Inflammation, Acute                  |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  A                                             |  57        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Atrophy                              |                                                                          |      2  2.5|
      Interstitial Cell, Hyperplasia       |                                                                          |      4  1.5|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Hyperplasia                          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Mediastinal, Hyperplasia             |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  M  M  +                                             |  51        |
      Hemorrhage                           |                                                                          |      3  2.0|
      Hyperplasia, Lymphoid                |       1     2                                                            |      3  1.7|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Congestion                           |                                                                          |      1  2.0|
      Fibrosis, Focal                      |       3                                                                  |      3  2.7|
      Hematopoietic Cell Proliferation     |                                                                          |      2  2.0|
      Necrosis                             |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  M  +  +  +  +                                             |  48        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  83                                                               
NTP Experiment-Test: 05041-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 11:52:17  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 4| 2|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 1| 6| 0|                                            |            |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 3| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    100MG/KG                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
    HIGHMALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Congestion                           |                         3                                                |      1  3.0|
      Hemorrhage                           |                                                                          |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  M  +  +  +  M  +  +  +  +                                             |  42        |
      Dilatation                           |             2                                                            |      1  2.0|
      Pigmentation                         |             2                                                            |      1  2.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Cyst Epithelial Inclusion            |                                                                          |      2  2.5|
      Subcutaneous Tissue, Edema           |                                                                          |      1  2.0|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Acute                           |                                                                          |      1  2.0|
      Subcutaneous Tissue, Thrombosis      |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   2        |
      Cyst                                 |                                                                          |      1  3.0|
      Inflammation, Chronic                |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cerebrum, Inflammation, Chronic      |    2                                                                     |      1  2.0|
      Meninges, Hemorrhage                 |                                                                          |      1  1.0|
      Meninges, Inflammation, Chronic      |    3                                                                     |      1  3.0|
      Thalamus, Compression                |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Necrosis                             |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Congestion                           |                         3                                                |     12  2.7|
      Foreign Body                         |                            2                                             |      7  2.0|
      Hemorrhage                           |                                                                          |      1  2.0|
      Hyperplasia, Adenomatous             |    2                                                                     |      2  1.5|
      Infiltration Cellular, Histiocyte    |                   1  2                                                   |     11  1.2|
      Inflammation, Granulomatous          |                                                                          |      1  2.0|
      Necrosis, Focal                      |                                                                          |      1  2.0|
      Necrosis, Multifocal                 |                                                                          |      2  1.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  84                                                               
NTP Experiment-Test: 05041-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         SUCCINIC ANHYDRIDE                                    Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 11:52:17  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 4| 2|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 1| 6| 0|                                            |            |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 3| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    100MG/KG                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
    HIGHMALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Alveolar Epithelium, Hyperplasia     |                                                                          |      1  3.0|
      Alveolus, Fibrosis, Focal            |                         2                                                |      1  2.0|
      Interstitium, Inflammation, Chronic  |                                                                          |      2  1.5|
      Mediastinum, Hemorrhage              |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  A                                             |  59        |
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Acute                           |                                                                          |      1  2.0|
      Olfactory Epithelium, Inflammation,  |                                                                          |            |
           Chronic                         |                                                                          |      1  2.0|
      Sinus, Foreign Body                  |             2        2                                                   |      3  2.0|
      Sinus, Fungus                        |                                                                          |      5  2.0|
      Sinus, Inflammation, Acute           |             2        2                                                   |     11  2.0|
      Turbinate, Inflammation, Acute       |                                                                          |      1  2.0|
      Turbinate, Inflammation, Chronic     |                                                                          |      3  1.7|
      Turbinate, Metaplasia, Squamous      |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Necrosis                             |                                                                          |      3  3.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     | +                 +                                                      |   8        |
      Lens Capsule, Cataract               | 2                                                                        |      2  2.0|
      Retina, Atrophy                      | 3                                                                        |      5  2.4|
      Sclera, Metaplasia, Osseous          | 2                 2                                                      |      4  2.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                   +                                                      |   3        |
      Inflammation, Chronic, Focal         |                   2                                                      |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Congestion                           |                                                                          |      1  2.0|
      Cyst                                 |                                                                          |      1  1.0|
      Mineralization                       |    1                                                                     |      2  1.0|
      Nephropathy                          |       1     1                                                            |     26  1.3|
      Pelvis, Mineralization               |                                                                          |      1  1.0|
      Renal Tubule, Pigmentation           |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Hemorrhage                           |                                                                          |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  85                                                               
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NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.