National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/1481

TR 380 Mouse Pathology Tables


                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                                          EPINEPHRINE HCL


NTP Experiment-Test: 05095-02                                                                                     Report: PEIRPT03
Study Type: CHRONIC                                                                                               Date: 09/13/94
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 00:50:54




       Facility:  Battelle Northwest

       Chemical CAS #:  55-31-2

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05095-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          EPINEPHRINE HCL                                      Date: 09/13/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 00:50:54  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        CONTROL      1.5MG/M3     3.0MG/M3                                               
                                                   FEMALE        FEMALE       FEMALE                                                
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Dead                                              11            7            9                                                  
    Moribund                                           7            8            7                                                  
  Survivors                                                                                                                         
    Moribund                                                                     1                                                  
    Terminal Sacrifice                                32           35           33                                                  
  Animals Examined Microscopically                    50           50           50                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (47)         (15)         (48)                                                
      Dilatation                                                    1 (7%)                                                          
   Intestine Large, Colon                             (49)         (15)         (50)                                                
      Inflammation, Chronic                                         1 (7%)                                                          
   Intestine Large, Rectum                            (50)         (15)         (50)                                                
      Prolapse                                                      1 (7%)                                                          
   Intestine Small, Ileum                             (49)         (14)         (50)                                                
      Amyloid Deposition                               1 (2%)                                                                       
      Hyperplasia, Lymphoid                            1 (2%)                                                                       
   Intestine Small, Jejunum                           (49)         (18)         (50)                                                
      Inflammation, Suppurative                                     1 (6%)                                                          
   Liver                                              (50)         (20)         (50)                                                
      Cyst                                             2 (4%)                                                                       
      Cytologic Alterations                                         1 (5%)                                                          
      Focal Cellular Change                                         1 (5%)       2 (4%)                                             
      Hemorrhage                                       1 (2%)                                                                       
      Infarct                                          1 (2%)                                                                       
      Infiltration Cellular, Lymphocyte                1 (2%)                    1 (2%)                                             
      Inflammation, Subacute                           2 (4%)                    3 (6%)                                             
      Necrosis                                         3 (6%)                    1 (2%)                                             
   Pancreas                                           (50)         (16)         (50)                                                
      Inflammation, Subacute                           1 (2%)                                                                       
      Acinus, Hypoplasia                                                         1 (2%)                                             
      Duct, Cyst                                                                 1 (2%)                                             
   Salivary Glands                                    (49)         (14)         (49)                                                
      Hemorrhage                                                    1 (7%)                                                          
   Stomach, Forestomach                               (50)         (19)         (49)                                                
      Hyperkeratosis                                   6 (12%)      1 (5%)       3 (6%)                                             
      Hyperplasia, Lymphoid                                         1 (5%)                                                          
      Inflammation, Subacute                                                     1 (2%)                                             
      Inflammation, Suppurative                                                  1 (2%)                                             
      Ulcer                                                         1 (5%)       1 (2%)                                             
      Epithelium, Hyperplasia                                       1 (5%)                                                          
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05095-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          EPINEPHRINE HCL                                      Date: 09/13/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 00:50:54  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        CONTROL      1.5MG/M3     3.0MG/M3                                               
                                                   FEMALE        FEMALE       FEMALE                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
   Stomach, Glandular                                 (50)         (15)         (50)                                                
      Hyperplasia                                      3 (6%)                                                                       
      Inflammation, Subacute                           1 (2%)                                                                       
      Mineralization                                   1 (2%)                    1 (2%)                                             
      Pigmentation                                     1 (2%)                                                                       
   Tooth                                              (1)                       (3)                                                 
      Abscess                                          1 (100%)                                                                     
      Developmental Malformation                                                 3 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (15)         (50)                                                
      Atrium, Thrombosis                               1 (2%)                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (16)         (50)                                                
      Hyperplasia                                                                1 (2%)                                             
      Hyperplasia, Focal                               1 (2%)                    1 (2%)                                             
      Hypertrophy, Focal                               2 (4%)       1 (6%)       1 (2%)                                             
   Adrenal Gland, Medulla                             (50)         (16)         (50)                                                
      Hyperplasia                                      1 (2%)       1 (6%)       2 (4%)                                             
   Pituitary Gland                                    (49)         (46)         (49)                                                
      Congestion                                       4 (8%)       1 (2%)       1 (2%)                                             
      Hyperplasia                                     18 (37%)     17 (37%)     22 (45%)                                            
      Pigmentation                                                  1 (2%)                                                          
      Pars Distalis, Hyperplasia                                    1 (2%)                                                          
      Pars Intermedia, Hyperplasia                     1 (2%)                                                                       
   Thyroid Gland                                      (49)         (18)         (48)                                                
      Infiltration Cellular, Lymphocyte                1 (2%)                                                                       
      Inflammation, Chronic                                         1 (6%)                                                          
      Follicular Cell, Cyst                                         1 (6%)                                                          
      Follicular Cell, Hyperplasia                     4 (8%)                    6 (13%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05095-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          EPINEPHRINE HCL                                      Date: 09/13/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 00:50:54  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        CONTROL      1.5MG/M3     3.0MG/M3                                               
                                                   FEMALE        FEMALE       FEMALE                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (50)         (26)         (50)                                                
      Corpora Amylacea                                 1 (2%)                                                                       
      Cyst                                            18 (36%)     12 (46%)     11 (22%)                                            
      Cyst, Multiple                                                1 (4%)                                                          
      Hemorrhage                                                                 1 (2%)                                             
      Mineralization                                                2 (8%)                                                          
      Pigmentation                                                  1 (4%)                                                          
      Germinal Epithelium, Hyperplasia                              1 (4%)                                                          
      Rete Ovarii, Hyperplasia                                                   1 (2%)                                             
   Uterus                                             (50)         (19)         (50)                                                
      Angiectasis                                                                1 (2%)                                             
      Dilatation                                       1 (2%)       1 (5%)                                                          
      Hyperplasia, Cystic                              1 (2%)                                                                       
      Hyperplasia, Lymphoid                                                      1 (2%)                                             
      Prolapse                                                                   1 (2%)                                             
      Thrombosis                                                                 1 (2%)                                             
      Artery, Thrombosis                                                         1 (2%)                                             
      Endometrium, Degeneration, Hyaline               1 (2%)                                                                       
      Endometrium, Hyperplasia                         8 (16%)      1 (5%)       8 (16%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (15)         (50)                                                
      Myelofibrosis                                    2 (4%)                    1 (2%)                                             
   Lymph Node                                         (50)         (29)         (49)                                                
      Iliac, Hyperplasia, Lymphoid                                  1 (3%)       1 (2%)                                             
      Mediastinal, Hyperplasia, Lymphoid                                         1 (2%)                                             
      Mesenteric, Congestion                           1 (2%)       1 (3%)                                                          
      Mesenteric, Hyperplasia, Lymphoid                2 (4%)                                                                       
      Renal, Hyperplasia, Lymphoid                                               2 (4%)                                             
   Lymph Node, Bronchial                              (45)         (20)         (49)                                                
      Hyperplasia, Lymphoid                                         3 (15%)      1 (2%)                                             
   Lymph Node, Mandibular                             (49)         (19)         (45)                                                
      Atrophy                                                                    1 (2%)                                             
      Hyperplasia, Lymphoid                                         3 (16%)      7 (16%)                                            
      Pigmentation                                     1 (2%)                    1 (2%)                                             
   Spleen                                             (50)         (25)         (50)                                                
      Atrophy                                                                    2 (4%)                                             
      Hematopoietic Cell Proliferation                 4 (8%)       2 (8%)                                                          
      Hyperplasia, Histiocytic                         1 (2%)                                                                       
      Hyperplasia, Lymphoid                            4 (8%)       3 (12%)      5 (10%)                                            
      Inflammation, Granulomatous                                                1 (2%)                                             
      Inflammation, Suppurative                                     1 (4%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05095-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          EPINEPHRINE HCL                                      Date: 09/13/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 00:50:54  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        CONTROL      1.5MG/M3     3.0MG/M3                                               
                                                   FEMALE        FEMALE       FEMALE                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (44)         (14)         (45)                                                
      Duct, Dilatation, Multifocal                                               1 (2%)                                             
   Skin                                               (49)         (23)         (49)                                                
      Alopecia                                         5 (10%)      6 (26%)      6 (12%)                                            
      Edema                                                         1 (4%)       2 (4%)                                             
      Inflammation, Chronic                                         1 (4%)       1 (2%)                                             
      Inflammation, Necrotizing                                     1 (4%)       1 (2%)                                             
      Ulcer                                                                      1 (2%)                                             
      Sebaceous Gland, Hyperplasia                                  1 (4%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (15)         (50)                                                
      Costochondral Junction, Degeneration                                       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (15)         (50)                                                
      Hemorrhage, Acute, Multifocal                                 1 (7%)                                                          
      Inflammation, Subacute                           1 (2%)                                                                       
      Mineralization                                   9 (18%)      3 (20%)     16 (32%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (27)         (50)                                                
      Congestion                                                                 1 (2%)                                             
      Hyperplasia, Lymphoid                                                      1 (2%)                                             
      Infiltration Cellular, Lymphocyte                2 (4%)       1 (4%)       1 (2%)                                             
      Infiltration Cellular, Histiocyte                                          1 (2%)                                             
      Inflammation, Granulomatous                      5 (10%)      2 (7%)       3 (6%)                                             
      Inflammation, Subacute                           2 (4%)       1 (4%)       1 (2%)                                             
      Thrombosis                                                    2 (7%)                                                          
      Alveolar Epithelium, Hyperplasia                 2 (4%)       2 (7%)       1 (2%)                                             
      Interstitium, Fibrosis                           1 (2%)                                                                       
   Nose                                               (50)         (48)         (50)                                                
      Inflammation, Suppurative                        1 (2%)       7 (15%)      8 (16%)                                            
      Olfactory Epithelium, Degeneration, Hyaline     44 (88%)     43 (90%)     47 (94%)                                            
      Olfactory Epithelium, Metaplasia                 1 (2%)                                                                       
      Olfactory Epithelium, Metaplasia, Focal         10 (20%)     21 (44%)     12 (24%)                                            
      Respiratory Epithelium, Degeneration             1 (2%)                                                                       
      Respiratory Epithelium, Degeneration, Hyaline    7 (14%)     28 (58%)     19 (38%)                                            
      Respiratory Epithelium, Metaplasia, Squamous                               1 (2%)                                             
      Respiratory Epithelium, Necrosis                                           1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05095-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          EPINEPHRINE HCL                                      Date: 09/13/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 00:50:54  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        CONTROL      1.5MG/M3     3.0MG/M3                                               
                                                   FEMALE        FEMALE       FEMALE                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (19)         (50)                                                
      Cyst                                             1 (2%)                    1 (2%)                                             
      Hemorrhage, Acute                                             1 (5%)                                                          
      Hydronephrosis                                   1 (2%)       1 (5%)                                                          
      Inflammation, Subacute                           1 (2%)                    2 (4%)                                             
      Metaplasia, Osseous                              1 (2%)                                                                       
      Glomerulus, Amyloid Deposition                   1 (2%)                                                                       
      Renal Tubule, Degeneration, Hyaline                           1 (5%)                                                          
   Urinary Bladder                                    (50)         (15)         (50)                                                
      Infiltration Cellular, Lymphocyte                                          1 (2%)                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05095-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          EPINEPHRINE HCL                                      Date: 09/13/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 00:50:54  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          CONTROL      1.5MG/M3     3.0MG/M3                                               
                                                   MALE          MALE         MALE                                                  
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Dead                                              10            4            4                                                  
    Moribund                                           7           12           10                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                33           34           36                                                  
  Animals Examined Microscopically                    50           50           50                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Rectum                            (50)         (15)         (50)                                                
      Inflammation, Suppurative                                                  1 (2%)                                             
   Intestine Small                                    (50)         (18)         (50)                                                
      Peyer's Patch, Hyperplasia, Lymphoid                                       1 (2%)                                             
   Intestine Small, Ileum                             (50)         (17)         (49)                                                
      Amyloid Deposition                                                         1 (2%)                                             
      Hyperplasia, Lymphoid                                         1 (6%)                                                          
   Intestine Small, Jejunum                           (50)         (17)         (50)                                                
      Hyperplasia, Lymphoid                                         1 (6%)       1 (2%)                                             
   Liver                                              (50)         (25)         (50)                                                
      Congestion                                       1 (2%)                                                                       
      Focal Cellular Change                            1 (2%)       1 (4%)       1 (2%)                                             
      Hemorrhage                                                                 1 (2%)                                             
      Infarct                                          1 (2%)       1 (4%)       3 (6%)                                             
      Inflammation, Subacute                                        1 (4%)       1 (2%)                                             
      Necrosis                                         1 (2%)       2 (8%)                                                          
      Bile Duct, Cyst                                                            1 (2%)                                             
      Serosa, Fibrosis, Chronic                                     1 (4%)                                                          
   Pancreas                                           (50)         (16)         (50)                                                
      Hemorrhage                                                                 1 (2%)                                             
      Duct, Cyst                                       1 (2%)                                                                       
   Stomach, Forestomach                               (47)         (16)         (50)                                                
      Hyperkeratosis                                                1 (6%)       2 (4%)                                             
      Inflammation, Subacute                           1 (2%)                    1 (2%)                                             
      Ulcer                                                                      1 (2%)                                             
   Stomach, Glandular                                 (49)         (16)         (50)                                                
      Hyperplasia                                      2 (4%)       1 (6%)       2 (4%)                                             
      Subserosa, Cyst                                  1 (2%)                                                                       
   Tooth                                              (2)                       (1)                                                 
      Inflammation, Suppurative                        2 (100%)                  1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 05095-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          EPINEPHRINE HCL                                      Date: 09/13/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 00:50:54  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          CONTROL      1.5MG/M3     3.0MG/M3                                               
                                                   MALE          MALE         MALE                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (16)         (50)                                                
      Artery, Inflammation, Subacute                   1 (2%)                                                                       
      Atrium, Thrombosis                                                         1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (32)         (48)                                                
      Hyperplasia                                                   1 (3%)       3 (6%)                                             
      Hyperplasia, Diffuse                                                       2 (4%)                                             
      Hyperplasia, Focal                               2 (4%)       4 (13%)      1 (2%)                                             
      Hypertrophy                                                   2 (6%)       3 (6%)                                             
      Hypertrophy, Diffuse                                          1 (3%)       3 (6%)                                             
      Hypertrophy, Focal                              16 (32%)     12 (38%)     13 (27%)                                            
   Adrenal Gland, Medulla                             (48)         (16)         (45)                                                
      Hyperplasia, Focal                               1 (2%)                                                                       
   Pituitary Gland                                    (50)         (16)         (48)                                                
      Cyst                                             1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Penis                                                           (2)                                                              
      Abscess                                                       1 (50%)                                                         
      Inflammation, Chronic                                         1 (50%)                                                         
   Preputial Gland                                    (13)         (9)          (7)                                                 
      Inflammation, Chronic                            1 (8%)       1 (11%)                                                         
      Inflammation, Suppurative                        5 (38%)      4 (44%)      4 (57%)                                            
      Duct, Dilatation                                 6 (46%)      4 (44%)      1 (14%)                                            
      Duct, Hyperplasia                                1 (8%)                                                                       
   Prostate                                           (48)         (13)         (49)                                                
      Inflammation, Suppurative                        2 (4%)       1 (8%)       1 (2%)                                             
   Seminal Vesicle                                    (2)          (4)          (1)                                                 
      Dilatation                                                    1 (25%)                                                         
      Inflammation, Chronic                            1 (50%)                                                                      
      Inflammation, Suppurative                        1 (50%)                                                                      
   Testes                                             (50)         (15)         (50)                                                
      Atrophy                                          1 (2%)                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
NTP Experiment-Test: 05095-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          EPINEPHRINE HCL                                      Date: 09/13/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 00:50:54  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          CONTROL      1.5MG/M3     3.0MG/M3                                               
                                                   MALE          MALE         MALE                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (16)         (50)                                                
      Hyperplasia, Neutrophil                          1 (2%)       1 (6%)                                                          
   Lymph Node                                         (49)         (20)         (50)                                                
      Mediastinal, Hyperplasia, Lymphoid                            1 (5%)                                                          
      Mesenteric, Hyperplasia, Lymphoid                1 (2%)                                                                       
      Mesenteric, Sinus, Dilatation                                 1 (5%)                                                          
      Renal, Hyperplasia, Lymphoid                                  1 (5%)                                                          
   Lymph Node, Bronchial                              (43)         (13)         (49)                                                
      Hyperplasia, Lymphoid                                         1 (8%)       1 (2%)                                             
   Lymph Node, Mandibular                             (43)         (12)         (41)                                                
      Hyperplasia, Lymphoid                            3 (7%)                    2 (5%)                                             
   Spleen                                             (50)         (20)         (50)                                                
      Atrophy                                                       1 (5%)                                                          
      Hematopoietic Cell Proliferation                 3 (6%)       2 (10%)      1 (2%)                                             
      Hyperplasia, Lymphoid                                                      2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (48)         (21)         (49)                                                
      Alopecia                                         3 (6%)       4 (19%)      3 (6%)                                             
      Inflammation, Necrotizing                                                  1 (2%)                                             
      Inflammation, Suppurative                        2 (4%)       1 (5%)       1 (2%)                                             
      Subcutaneous Tissue, Inflammation, Chronic       2 (4%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (16)         (50)                                                
      Abscess                                                       1 (6%)                                                          
      Infiltration Cellular, Lymphocyte                                          1 (2%)                                             
      Mineralization                                  30 (60%)      2 (13%)     31 (62%)                                            
      Meninges, Hyperplasia, Lymphoid                                            1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (32)         (50)                                                
      Congestion                                       2 (4%)                    2 (4%)                                             
      Hemorrhage, Acute                                             1 (3%)                                                          
      Hemorrhage, Focal                                                          4 (8%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    9                                                              
NTP Experiment-Test: 05095-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          EPINEPHRINE HCL                                      Date: 09/13/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 00:50:54  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          CONTROL      1.5MG/M3     3.0MG/M3                                               
                                                   MALE          MALE         MALE                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Infiltration Cellular, Histiocyte                2 (4%)       3 (9%)                                                          
      Inflammation, Subacute                           4 (8%)       1 (3%)       2 (4%)                                             
      Inflammation, Suppurative                                     3 (9%)       1 (2%)                                             
      Leukocytosis                                                               1 (2%)                                             
      Alveolar Epithelium, Hyperplasia                 7 (14%)      6 (19%)      6 (12%)                                            
      Alveolar Epithelium, Hyperplasia, Focal          1 (2%)                    2 (4%)                                             
      Bronchiole, Hyperplasia                                                    2 (4%)                                             
      Bronchiole, Hyperplasia, Focal                                5 (16%)                                                         
      Bronchus, Ulcer, Focal                                                     1 (2%)                                             
      Pleura, Inflammation, Subacute                   1 (2%)                                                                       
   Nose                                               (50)         (50)         (50)                                                
      Hemorrhage, Acute                                             1 (2%)                                                          
      Inflammation, Suppurative                        1 (2%)       4 (8%)       3 (6%)                                             
      Nasolacrimal Duct, Inflammation, Suppurative                  1 (2%)                                                          
      Olfactory Epithelium, Degeneration, Focal,                                                                                    
           Hyaline                                                               1 (2%)                                             
      Olfactory Epithelium, Degeneration, Hyaline      3 (6%)      17 (34%)     39 (78%)                                            
      Olfactory Epithelium, Metaplasia, Focal          8 (16%)     11 (22%)      8 (16%)                                            
      Respiratory Epithelium, Degeneration, Hyaline    5 (10%)      2 (4%)       2 (4%)                                             
      Respiratory Epithelium, Hyperplasia, Focal       1 (2%)       2 (4%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (16)         (50)                                                
      Atrophy                                                       1 (6%)                                                          
      Bacterium, Acute                                 1 (2%)                                                                       
      Developmental Malformation                                    1 (6%)                                                          
      Fibrosis, Focal                                  1 (2%)                                                                       
      Hemorrhage, Focal                                                          1 (2%)                                             
      Infiltration Cellular, Lymphocyte                1 (2%)                                                                       
      Inflammation, Chronic, Focal                     1 (2%)                                                                       
      Inflammation, Suppurative                                     1 (6%)       1 (2%)                                             
      Metaplasia, Osseous                              1 (2%)                    1 (2%)                                             
      Mineralization                                                1 (6%)       1 (2%)                                             
      Nephropathy                                      1 (2%)                    1 (2%)                                             
      Pelvis, Inflammation, Chronic                    2 (4%)       2 (13%)      2 (4%)                                             
      Pelvis, Inflammation, Suppurative                             1 (6%)       1 (2%)                                             
      Renal Tubule, Casts                                                        2 (4%)                                             
      Renal Tubule, Degeneration                                                 2 (4%)                                             
      Renal Tubule, Dilatation                                                   1 (2%)                                             
      Renal Tubule, Regeneration                       3 (6%)                    3 (6%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   10                                                              
NTP Experiment-Test: 05095-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          EPINEPHRINE HCL                                      Date: 09/13/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 00:50:54  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          CONTROL      1.5MG/M3     3.0MG/M3                                               
                                                   MALE          MALE         MALE                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Renal Tubule, Regeneration, Focal                1 (2%)                    1 (2%)                                             
   Urinary Bladder                                    (50)         (16)         (50)                                                
      Concretion                                       1 (2%)                                                                       
      Dilatation                                       1 (2%)       1 (6%)                                                          
      Hyperplasia                                                   1 (6%)                                                          
      Inflammation, Subacute                           1 (2%)       1 (6%)                                                          
      Inflammation, Suppurative                        1 (2%)                                                                       
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   11                                                              
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