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TR 380 Mouse Pathology Tables

NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11 
LAB: Battelle Northwest                                        DATE: 09/13/94   
EXP: 05095                     EPINEPHRINE HCL                 TIME: 01:00:21   
TEST: 02              CAGES FROM 0000 TO LAST CAGE             PAGE:   1        
TEST TYPE: CHRONIC          ROUTE: RESPIRATORY EXPOSURE WHOLE  NTP C#: 55663    
CONT: N01-ES-38061                                             CAS: 55-31-2     
PATHOLOGIST: E. GIDDENS                      S. EUSTIS                          
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REASONS FOR REMOVAL:                                                            
                                                                                
ALL                                                                             
                                                                                
                                                                                
REMOVAL DATE RANGE:                                                             


ALL                                                                             
                                                                                
TREATMENT GROUPS:                                                               
                                                                                
INCLUDE ALL                                                                     

NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11
LAB: Battelle Northwest                                        DATE: 09/13/94  
EXP: 05095                     EPINEPHRINE HCL                 TIME: 01:00:21  
TEST: 02              CAGES FROM 0000 TO LAST CAGE                             
TEST TYPE: CHRONIC          ROUTE: RESPIRATORY EXPOSURE WHOLE  NTP C#: 55663   
CONT: N01-ES-38061                                             CAS: 55-31-2    
PATHOLOGIST: E. GIDDENS                      S. EUSTIS                         

                                  EPINEPHRINE HCL


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 741 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = CONTROL                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 17     CENSORED DEATHS 0    TERMINAL 33        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      352   409   551   567   570   573   578   606   610   630                 |
 |      635   686   689   699   708   708   709                                   |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 1.5MG/M3                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 16     CENSORED DEATHS 0    TERMINAL 34        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      220   419   424   456   465   498   525   542   571   640                 |
 |      654   659   668   672   689   721                                         |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 3.0MG/M3                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 14     CENSORED DEATHS 0    TERMINAL 36        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      225   345   381   421   510   538   545   553   604   637                 |
 |      694   702   724   740                                                     |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================

                                  EPINEPHRINE HCL


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 741 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   741 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |CONTROL    |   100.0 100.0 100.0  98.0  96.0  96.0  96.0  86.0  78.0  66.0      |
 |           |                                                                    |
 |           |                                                                    |
 |1.5MG/M3   |   100.0 100.0  98.0  98.0  94.0  90.0  84.0  82.0  76.0  68.0      |
 |           |                                                                    |
 |           |                                                                    |
 |3.0MG/M3   |   100.0 100.0  98.0  96.0  92.0  92.0  86.0  82.0  80.0  72.0      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                    DOSE                        |
 |                                                                                |
 |                                CONTROL          1.5MG/M3         3.0MG/M3      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       66.0%            68.0%            72.0%         |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=0.666N         P=1.000N         P=0.727N      |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       604.7            551.4            544.2         |
 |NATURAL DEATHS (C)      |       (24.7)           (33.5)           (41.6)        |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       694.7            680.3            685.9         |
 |(STANDARD ERROR)        |       (12.4)           (16.4)           (17.0)        |
 |                        |                                                       |
 ==================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                                  EPINEPHRINE HCL


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 742 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = CONTROL                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 18     CENSORED DEATHS 0    TERMINAL 32        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      228   324   503   558   566   615   667   679   683   689                 |
 |      707   713   714   714   720   724   731   732                             |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 1.5MG/M3                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 15     CENSORED DEATHS 0    TERMINAL 35        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      384   465   504   539   581   607   616   640   658   661                 |
 |      692   693   693   693   716                                               |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 3.0MG/M3                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 16     CENSORED DEATHS 0    TERMINAL 34        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      268   342   421   425   609   661   672   680   685   692                 |
 |      693   693   704   728   730   731                                         |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================

                                  EPINEPHRINE HCL


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 742 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   742 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |CONTROL    |   100.0 100.0  98.0  96.0  96.0  96.0  94.0  90.0  88.0  64.0      |
 |           |                                                                    |
 |           |                                                                    |
 |1.5MG/M3   |   100.0 100.0 100.0 100.0  98.0  96.0  92.0  90.0  80.0  70.0      |
 |           |                                                                    |
 |           |                                                                    |
 |3.0MG/M3   |   100.0 100.0  98.0  96.0  92.0  92.0  92.0  92.0  88.0  68.0      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                    DOSE                        |
 |                                                                                |
 |                                CONTROL          1.5MG/M3         3.0MG/M3      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       64.0%            70.0%            68.0%         |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=0.781N         P=0.768N         P=0.852N      |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       625.9            609.5            608.4         |
 |NATURAL DEATHS (C)      |       (34.1)           (25.2)           (38.1)        |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       700.2            702.2            699.2         |
 |(STANDARD ERROR)        |       (14.4)           (11.4)           (14.9)        |
 |                        |                                                       |
 ==================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                                                          EPINEPHRINE HCL
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        CONTROL          = 1
                                                        1.5MG/M3         = 2
                                                        3.0MG/M3         = 3

------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  100 + 1                                  23                   1
      |
      |                                    23                  31        12
      |
   96 +                                                        3     3   122                   1
      |
      |                                                              3     2     2             1 1
      |
   92 +                                                                    3     22     3        11
      |
P     |                                                                           2    23    3
E     |
R  88 +                                                                                2   2 33   11
C     |
E     |                                                                                    2  23   1    1
N     |
T  84 +                                                                                       23  2     11
      |
S     |                                                                                           2     31 132
U     |
R  80 +                                                                                                    112 2      3
V     |
I     |                                                                                                     1  2 2  1 33
V     |
A  76 +                                                                                                          22 11 3  3
L     |
      |                                                                                                              11   3  3
      |
   72 +                                                                                                           2  21 1    3
      |
      |                                                                                                              2   2
      |
   68 +                                                                                                                  2   2
      |
      |                                                                                                                 1    1
      |
   64 +
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 6 obs hidden.

                                                          EPINEPHRINE HCL
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        CONTROL          = 1
                                                        1.5MG/M3         = 2
                                                        3.0MG/M3         = 3

----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  100 + 1                                   1      3                 2
      |
      |                                     1      3        1 3      2            2
      |                                                     1 3            3      2    1
   95 +
      |                                                                                1     2  1
      |                                                                    3                 2  11 2    3
      |
P  90 +                                                                                          1 2    21       3
E     |
R     |                                                                                                 21       31
C     |                                                                                                  2   2    113
E  85 +
N     |                                                                                                      2 2   11
T     |                                                                                                        2 2  11
      |
S  80 +                                                                                                          2   1 1
U     |
R     |                                                                                                                11
V     |                                                                                                              3 3
I  75 +
V     |                                                                                                                3  3
A     |                                                                                                              2  113 3
L     |
   70 +                                                                                                                  11  2
      |
      |                                                                                                                   1 13
      |
   65 +
      |                                                                                                                     11
      |
      |
   60 +
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 14 obs hidden.

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