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https://ntp.niehs.nih.gov/go/1493

TR 380 Rat Pathology Tables


                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                                          EPINEPHRINE HCL


NTP Experiment-Test: 05095-01                                                                                     Report: PEIRPT03
Study Type: CHRONIC                                                                                               Date: 09/12/94
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 23:29:54




       Facility:  Battelle Northwest

       Chemical CAS #:  55-31-2

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05095-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          EPINEPHRINE HCL                                      Date: 09/12/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 23:29:54  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   CONTROL      1.5MG/M3     5.0MG/M3                                               
                                                   FEMALE        FEMALE       FEMALE                                                
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Moribund                                          14           16           14                                                  
    Dead                                               4            5            6                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                32           29           30                                                  
  Animals Examined Microscopically                    50           50           50                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (45)         (17)         (44)                                                
      Parasite Metazoan                                3 (7%)       1 (6%)       1 (2%)                                             
      Artery, Inflammation                                                       2 (5%)                                             
   Intestine Large, Colon                             (49)         (20)         (45)                                                
      Hemorrhage                                                                 1 (2%)                                             
      Parasite Metazoan                                3 (6%)                    1 (2%)                                             
   Intestine Large, Rectum                            (49)         (20)         (46)                                                
      Parasite Metazoan                                1 (2%)                                                                       
   Intestine Small                                    (50)         (20)         (44)                                                
      Muscularis, Hyperplasia                                                    1 (2%)                                             
   Intestine Small, Duodenum                          (50)         (20)         (44)                                                
      Artery, Inflammation                                                       1 (2%)                                             
   Intestine Small, Ileum                             (45)         (18)         (44)                                                
      Inflammation, Chronic                            1 (2%)                                                                       
      Artery, Inflammation                                                       1 (2%)                                             
   Intestine Small, Jejunum                           (48)         (19)         (44)                                                
      Inflammation, Chronic                            1 (2%)                                                                       
      Artery, Inflammation                                                       1 (2%)                                             
   Liver                                              (50)         (31)         (47)                                                
      Angiectasis                                      2 (4%)       1 (3%)       2 (4%)                                             
      Basophilic Focus                                21 (42%)      9 (29%)     22 (47%)                                            
      Basophilic Focus, Multiple                                    1 (3%)                                                          
      Clear Cell Focus                                 3 (6%)       2 (6%)       3 (6%)                                             
      Developmental Malformation                       2 (4%)       9 (29%)      6 (13%)                                            
      Eosinophilic Focus                               3 (6%)       1 (3%)       1 (2%)                                             
      Eosinophilic Focus, Multiple                                               1 (2%)                                             
      Hematopoietic Cell Proliferation                                           2 (4%)                                             
      Hyperplasia, Focal                                            1 (3%)                                                          
      Inflammation, Granulomatous                     19 (38%)      6 (19%)     21 (45%)                                            
      Inflammation, Suppurative                                                  2 (4%)                                             
      Mixed Cell Focus                                                           1 (2%)                                             
      Necrosis                                         7 (14%)      3 (10%)      3 (6%)                                             
      Artery, Inflammation                                                       1 (2%)                                             
      Artery, Mineralization                                                     1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05095-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          EPINEPHRINE HCL                                      Date: 09/12/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 23:29:54  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   CONTROL      1.5MG/M3     5.0MG/M3                                               
                                                   FEMALE        FEMALE       FEMALE                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Bile Duct, Hyperplasia                          10 (20%)      9 (29%)      8 (17%)                                            
      Hepatocyte, Cytomegaly                           1 (2%)                                                                       
      Hepatocyte, Vacuolization Cytoplasmic           11 (22%)      7 (23%)     11 (23%)                                            
   Mesentery                                          (1)                       (2)                                                 
      Inflammation, Chronic                                                      1 (50%)                                            
      Necrosis                                                                   1 (50%)                                            
   Pancreas                                           (49)         (21)         (47)                                                
      Fibrosis                                                                   1 (2%)                                             
      Acinus, Atrophy                                  7 (14%)      7 (33%)     11 (23%)                                            
      Artery, Inflammation                                                       2 (4%)                                             
   Salivary Glands                                    (50)         (21)         (48)                                                
      Inflammation, Suppurative                        1 (2%)                                                                       
      Karyomegaly                                      1 (2%)                                                                       
      Duct, Hyperplasia                                1 (2%)                                                                       
   Stomach, Forestomach                               (50)         (21)         (48)                                                
      Acanthosis                                       1 (2%)       1 (5%)       4 (8%)                                             
      Developmental Malformation                                                 1 (2%)                                             
      Hyperkeratosis                                                             1 (2%)                                             
      Inflammation, Suppurative                        2 (4%)                    4 (8%)                                             
      Ulcer                                            2 (4%)       1 (5%)                                                          
   Stomach, Glandular                                 (49)         (21)         (47)                                                
      Inflammation, Chronic                                                      1 (2%)                                             
      Inflammation, Suppurative                                                  1 (2%)                                             
      Mineralization                                                1 (5%)       2 (4%)                                             
      Artery, Inflammation                                                       1 (2%)                                             
      Epithelium, Hyperplasia                          1 (2%)                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (21)         (49)                                                
      Cardiomyopathy                                  13 (26%)      6 (29%)     20 (41%)                                            
      Mineralization                                                1 (5%)       2 (4%)                                             
      Thrombosis                                       2 (4%)                    4 (8%)                                             
      Artery, Inflammation                                                       1 (2%)                                             
      Artery, Mineralization                                        1 (5%)                                                          
      Myocardium, Hemorrhage                           1 (2%)                                                                       
      Myocardium, Necrosis                                          1 (5%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (23)         (47)                                                
      Angiectasis                                                                1 (2%)                                             
      Hemorrhage                                                    1 (4%)       2 (4%)                                             
      Hyperplasia                                     13 (26%)                   8 (17%)                                            
      Necrosis                                                      2 (9%)       1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05095-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          EPINEPHRINE HCL                                      Date: 09/12/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 23:29:54  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   CONTROL      1.5MG/M3     5.0MG/M3                                               
                                                   FEMALE        FEMALE       FEMALE                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Thrombosis                                                                 1 (2%)                                             
      Vacuolization Cytoplasmic                       21 (42%)      9 (39%)     17 (36%)                                            
   Adrenal Gland, Medulla                             (50)         (22)         (47)                                                
      Hyperplasia                                      7 (14%)      2 (9%)       4 (9%)                                             
      Hyperplasia, Focal                               1 (2%)                                                                       
      Vacuolization Cytoplasmic                        1 (2%)                                                                       
   Parathyroid Gland                                  (41)         (20)         (44)                                                
      Hyperplasia                                                   1 (5%)       5 (11%)                                            
   Pituitary Gland                                    (49)         (38)         (47)                                                
      Cyst                                                          3 (8%)       1 (2%)                                             
      Pars Distalis, Angiectasis                       3 (6%)                    1 (2%)                                             
      Pars Distalis, Hyperplasia                       3 (6%)       1 (3%)       3 (6%)                                             
      Pars Distalis, Hyperplasia, Focal                             1 (3%)                                                          
      Pars Intermedia, Angiectasis                                               1 (2%)                                             
   Thyroid Gland                                      (50)         (21)         (47)                                                
      Ultimobranchial Cyst                             1 (2%)       1 (5%)       1 (2%)                                             
      C-Cell, Hyperplasia                             17 (34%)      9 (43%)     11 (23%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (48)         (21)         (47)                                                
      Cyst                                             2 (4%)                                                                       
      Hyperplasia                                      5 (10%)      2 (10%)      1 (2%)                                             
      Inflammation, Suppurative                        5 (10%)      3 (14%)      4 (9%)                                             
      Metaplasia, Squamous                                                       1 (2%)                                             
   Ovary                                              (50)         (22)         (47)                                                
      Cyst                                             7 (14%)                   5 (11%)                                            
      Inflammation, Chronic                            1 (2%)                    1 (2%)                                             
   Uterus                                             (50)         (25)         (48)                                                
      Decidual Reaction                                1 (2%)                                                                       
      Dilatation                                       3 (6%)       1 (4%)       1 (2%)                                             
      Hemorrhage                                       1 (2%)       1 (4%)                                                          
      Inflammation, Suppurative                        1 (2%)       2 (8%)                                                          
      Metaplasia, Squamous                             1 (2%)                                                                       
      Prolapse                                                      1 (4%)                                                          
      Endometrium, Hyperplasia                         2 (4%)       1 (4%)                                                          
   Vagina                                                                       (2)                                                 
      Inflammation, Suppurative                                                  1 (50%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05095-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          EPINEPHRINE HCL                                      Date: 09/12/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 23:29:54  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   CONTROL      1.5MG/M3     5.0MG/M3                                               
                                                   FEMALE        FEMALE       FEMALE                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Blood                                                                        (1)                                                 
      Neutrophilia                                                               1 (100%)                                           
   Bone Marrow                                        (50)         (21)         (47)                                                
      Fibrosis                                                      1 (5%)                                                          
      Hyperplasia                                                                1 (2%)                                             
   Lymph Node                                         (48)         (22)         (48)                                                
      Mediastinal, Hyperplasia                                      1 (5%)                                                          
   Lymph Node, Mandibular                             (48)         (17)         (45)                                                
      Hyperplasia                                                   1 (6%)       2 (4%)                                             
   Spleen                                             (50)         (26)         (47)                                                
      Developmental Malformation                                    1 (4%)                                                          
      Fibrosis                                         1 (2%)       2 (8%)       3 (6%)                                             
      Hematopoietic Cell Proliferation                 3 (6%)       1 (4%)       5 (11%)                                            
      Infarct                                                                    1 (2%)                                             
      Pigmentation                                                  1 (4%)                                                          
   Thymus                                             (50)         (19)         (47)                                                
      Cyst                                             1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (49)         (28)         (49)                                                
      Galactocele                                      1 (2%)       1 (4%)                                                          
      Hyperplasia                                                   1 (4%)                                                          
   Skin                                               (48)         (22)         (48)                                                
      Acanthosis                                       1 (2%)                                                                       
      Inflammation, Chronic                            1 (2%)                                                                       
      Inflammation, Suppurative                                     1 (5%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                                 (1)          (1)                                                 
      Diaphragm, Developmental Malformation                         1 (100%)     1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (21)         (49)                                                
      Compression                                     10 (20%)      6 (29%)      9 (18%)                                            
      Congestion                                       1 (2%)                                                                       
      Hemorrhage                                       6 (12%)                                                                      
      Thrombosis                                                                 1 (2%)                                             
      Ventricle, Dilatation                            1 (2%)       1 (5%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05095-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          EPINEPHRINE HCL                                      Date: 09/12/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 23:29:54  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   CONTROL      1.5MG/M3     5.0MG/M3                                               
                                                   FEMALE        FEMALE       FEMALE                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Larynx                                             (50)         (21)         (47)                                                
      Foreign Body                                                  1 (5%)       5 (11%)                                            
      Inflammation, Chronic                                         2 (10%)      4 (9%)                                             
      Inflammation, Suppurative                       12 (24%)      4 (19%)     17 (36%)                                            
      Mineralization                                                1 (5%)                                                          
      Epithelium, Hyperplasia                          2 (4%)       2 (10%)      1 (2%)                                             
   Lung                                               (50)         (23)         (48)                                                
      Foreign Body                                                  1 (4%)       1 (2%)                                             
      Hemorrhage                                       2 (4%)                                                                       
      Inflammation, Granulomatous                                                1 (2%)                                             
      Mineralization                                                1 (4%)       2 (4%)                                             
      Alveolar Epithelium, Hyperplasia                                           2 (4%)                                             
      Alveolus, Edema                                               1 (4%)                                                          
      Alveolus, Infiltration Cellular, Histiocyte      5 (10%)      7 (30%)      6 (13%)                                            
      Alveolus, Inflammation, Suppurative              3 (6%)       1 (4%)       5 (10%)                                            
      Artery, Inflammation                                                       2 (4%)                                             
      Bronchiole, Inflammation, Suppurative                         1 (4%)                                                          
   Nose                                               (50)         (50)         (46)                                                
      Dilatation                                                    1 (2%)                                                          
      Foreign Body                                     1 (2%)       5 (10%)      1 (2%)                                             
      Inflammation, Chronic                                                      1 (2%)                                             
      Inflammation, Suppurative                        1 (2%)      10 (20%)      6 (13%)                                            
      Parasite Metazoan                                1 (2%)                                                                       
      Glands, Dilatation                               4 (8%)      15 (30%)     37 (80%)                                            
      Nasolacrimal Duct, Inflammation, Suppurative                  1 (2%)       1 (2%)                                             
      Respiratory Epithelium, Hyperplasia                          12 (24%)     13 (28%)                                            
      Respiratory Epithelium, Metaplasia, Squamous                  2 (4%)       3 (7%)                                             
   Trachea                                            (50)         (21)         (47)                                                
      Inflammation, Suppurative                                     1 (5%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                (1)                                                                           
      Acanthosis                                       1 (100%)                                                                     
      Inflammation, Granulomatous                      1 (100%)                                                                     
   Eye                                                (5)          (7)          (2)                                                 
      Atrophy                                          1 (20%)                                                                      
      Lens, Cataract                                   3 (60%)      7 (100%)     2 (100%)                                           
   Lacrimal Gland                                     (3)          (1)          (1)                                                 
      Degeneration                                                               1 (100%)                                           
      Inflammation, Chronic                            3 (100%)     1 (100%)     1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05095-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          EPINEPHRINE HCL                                      Date: 09/12/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 23:29:54  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   CONTROL      1.5MG/M3     5.0MG/M3                                               
                                                   FEMALE        FEMALE       FEMALE                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (23)         (48)                                                
      Cyst                                             1 (2%)                                                                       
      Infarct                                          1 (2%)                                                                       
      Mineralization                                   1 (2%)       1 (4%)       3 (6%)                                             
      Nephropathy, Chronic                            49 (98%)     21 (91%)     47 (98%)                                            
      Pelvis, Dilatation                                                         1 (2%)                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 05095-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          EPINEPHRINE HCL                                      Date: 09/12/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 23:29:54  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     CONTROL      1.5MG/M3     5.0MG/M3                                               
                                                   MALE          MALE         MALE                                                  
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Moribund                                          17           17           13                                                  
    Dead                                                            6            5                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                33           26           32                                                  
    Moribund                                                        1                                                               
  Animals Examined Microscopically                    50           50           50                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (49)         (22)         (46)                                                
      Hemorrhage                                       1 (2%)       3 (14%)                                                         
      Parasite Metazoan                                5 (10%)                   2 (4%)                                             
      Artery, Inflammation, Chronic                    1 (2%)                                                                       
   Intestine Large, Colon                             (50)         (20)         (47)                                                
      Parasite Metazoan                                4 (8%)       4 (20%)                                                         
   Intestine Large, Rectum                            (50)         (20)         (45)                                                
      Parasite Metazoan                                7 (14%)                   4 (9%)                                             
   Liver                                              (50)         (33)         (49)                                                
      Angiectasis                                      2 (4%)                                                                       
      Angiectasis, Focal                                                         1 (2%)                                             
      Basophilic Focus                                17 (34%)      5 (15%)     22 (45%)                                            
      Clear Cell Focus                                18 (36%)      1 (3%)       7 (14%)                                            
      Developmental Malformation                       5 (10%)      4 (12%)      2 (4%)                                             
      Eosinophilic Focus                               1 (2%)                                                                       
      Fibrosis                                         1 (2%)                                                                       
      Inflammation, Granulomatous                     10 (20%)      3 (9%)       9 (18%)                                            
      Inflammation, Suppurative                                                  1 (2%)                                             
      Necrosis                                         1 (2%)       5 (15%)      2 (4%)                                             
      Thrombosis, Multiple                             1 (2%)                                                                       
      Bile Duct, Fibrosis                              7 (14%)                   2 (4%)                                             
      Bile Duct, Hyperplasia                          33 (66%)     14 (42%)     27 (55%)                                            
      Hepatocyte, Vacuolization Cytoplasmic            5 (10%)      5 (15%)      7 (14%)                                            
   Mesentery                                          (5)          (5)          (2)                                                 
      Fibrosis                                         1 (20%)                                                                      
      Hemorrhage                                       1 (20%)                                                                      
      Inflammation, Chronic                            4 (80%)      2 (40%)      2 (100%)                                           
      Necrosis                                                      1 (20%)                                                         
      Fat, Necrosis                                                              1 (50%)                                            
   Pancreas                                           (50)         (23)         (49)                                                
      Fibrosis                                         1 (2%)                                                                       
      Inflammation, Chronic                            1 (2%)                    1 (2%)                                             
      Acinus, Atrophy                                 19 (38%)     11 (48%)     18 (37%)                                            
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
NTP Experiment-Test: 05095-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          EPINEPHRINE HCL                                      Date: 09/12/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 23:29:54  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     CONTROL      1.5MG/M3     5.0MG/M3                                               
                                                   MALE          MALE         MALE                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Artery, Inflammation                                          1 (4%)                                                          
   Salivary Glands                                    (50)         (24)         (49)                                                
      Hemorrhage                                                    1 (4%)                                                          
      Inflammation, Chronic                            3 (6%)                    3 (6%)                                             
      Karyomegaly                                      3 (6%)                    4 (8%)                                             
   Stomach, Forestomach                               (49)         (26)         (48)                                                
      Acanthosis                                       2 (4%)       3 (12%)      3 (6%)                                             
      Diverticulum                                                  1 (4%)                                                          
      Fibrosis                                                      1 (4%)                                                          
      Hyperkeratosis                                   2 (4%)                    3 (6%)                                             
      Inflammation, Suppurative                        5 (10%)      2 (8%)       4 (8%)                                             
      Ulcer                                            2 (4%)       2 (8%)       1 (2%)                                             
      Muscularis, Hyperplasia                                                    1 (2%)                                             
   Stomach, Glandular                                 (50)         (25)         (48)                                                
      Atrophy                                          1 (2%)                                                                       
      Cyst                                             1 (2%)                                                                       
      Erosion                                          3 (6%)                                                                       
      Fibrosis                                         2 (4%)                    2 (4%)                                             
      Hyperplasia, Lymphoid                            1 (2%)                                                                       
      Inflammation, Chronic                            3 (6%)                    2 (4%)                                             
      Inflammation, Suppurative                        1 (2%)       2 (8%)       2 (4%)                                             
      Epithelium, Hyperplasia                                       1 (4%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (24)         (50)                                                
      Cardiomyopathy                                  24 (48%)      7 (29%)     28 (56%)                                            
      Thrombosis                                       1 (2%)                    2 (4%)                                             
      Atrium, Dilatation                               1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (23)         (49)                                                
      Developmental Malformation                                                 1 (2%)                                             
      Hemorrhage                                                                 1 (2%)                                             
      Hyperplasia                                      8 (16%)                   5 (10%)                                            
      Mineralization                                   1 (2%)                                                                       
      Vacuolization Cytoplasmic                       19 (38%)      8 (35%)     13 (27%)                                            
      Vacuolization Nuclear                            1 (2%)                                                                       
   Adrenal Gland, Medulla                             (50)         (25)         (48)                                                
      Hyperplasia                                     14 (28%)      2 (8%)      12 (25%)                                            
      Hyperplasia, Focal                                                         1 (2%)                                             
      Necrosis                                         1 (2%)                                                                       
   Islets, Pancreatic                                 (50)         (24)         (49)                                                
      Hyperplasia                                      2 (4%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    9                                                              
NTP Experiment-Test: 05095-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          EPINEPHRINE HCL                                      Date: 09/12/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 23:29:54  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     CONTROL      1.5MG/M3     5.0MG/M3                                               
                                                   MALE          MALE         MALE                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
   Parathyroid Gland                                  (43)         (19)         (37)                                                
      Hyperplasia                                      1 (2%)                    1 (3%)                                             
   Pituitary Gland                                    (50)         (36)         (48)                                                
      Cyst                                                          2 (6%)                                                          
      Pars Distalis, Angiectasis                                                 1 (2%)                                             
      Pars Distalis, Hyperplasia                       3 (6%)       1 (3%)       1 (2%)                                             
   Thyroid Gland                                      (50)         (24)         (49)                                                
      C-Cell, Hyperplasia                              9 (18%)      3 (13%)      6 (12%)                                            
      Follicular Cell, Cyst                            1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (46)         (27)         (39)                                                
      Angiectasis                                                   1 (4%)                                                          
      Inflammation, Chronic                                                      1 (3%)                                             
   Preputial Gland                                    (49)         (25)         (49)                                                
      Cyst                                             3 (6%)       2 (8%)       4 (8%)                                             
      Inflammation, Suppurative                        9 (18%)      1 (4%)      10 (20%)                                            
   Prostate                                           (50)         (25)         (49)                                                
      Hyperplasia                                      2 (4%)                                                                       
      Inflammation, Suppurative                       12 (24%)      6 (24%)      8 (16%)                                            
   Seminal Vesicle                                    (50)         (24)         (49)                                                
      Inflammation, Suppurative                        8 (16%)      3 (13%)      7 (14%)                                            
   Testes                                             (50)         (47)         (50)                                                
      Atrophy                                         35 (70%)     23 (49%)     41 (82%)                                            
      Mineralization                                   1 (2%)                    1 (2%)                                             
      Artery, Inflammation                             5 (10%)      2 (4%)       3 (6%)                                             
      Interstitial Cell, Hyperplasia                   4 (8%)                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (23)         (49)                                                
      Atrophy                                          1 (2%)                                                                       
      Fibrosis                                         1 (2%)                                                                       
   Lymph Node                                         (50)         (28)         (50)                                                
      Renal, Hyperplasia                                            1 (4%)                                                          
   Spleen                                             (50)         (32)         (49)                                                
      Developmental Malformation                                                 1 (2%)                                             
      Fibrosis                                         3 (6%)       3 (9%)       2 (4%)                                             
      Hematopoietic Cell Proliferation                 1 (2%)                    1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   10                                                              
NTP Experiment-Test: 05095-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          EPINEPHRINE HCL                                      Date: 09/12/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 23:29:54  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     CONTROL      1.5MG/M3     5.0MG/M3                                               
                                                   MALE          MALE         MALE                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Hemorrhage                                                                 1 (2%)                                             
      Infarct                                          2 (4%)                    3 (6%)                                             
      Pigmentation, Hemosiderin                                                  1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (35)         (20)         (41)                                                
      Galactocele                                      1 (3%)                                                                       
      Hyperplasia                                                                1 (2%)                                             
   Skin                                               (50)         (26)         (50)                                                
      Acanthosis                                                                 1 (2%)                                             
      Cyst Epithelial Inclusion                        1 (2%)       3 (12%)      2 (4%)                                             
      Hyperkeratosis                                                             1 (2%)                                             
      Inflammation, Chronic                            1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                    (2)          (1)          (1)                                                 
      Diaphragm, Developmental Malformation            1 (50%)                   1 (100%)                                           
      Diaphragm, Fibrosis                              1 (50%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (24)         (50)                                                
      Compression                                      9 (18%)     11 (46%)      3 (6%)                                             
      Congestion                                       1 (2%)                                                                       
      Gliosis                                          1 (2%)                                                                       
      Hemorrhage                                       3 (6%)       6 (25%)      6 (12%)                                            
      Mineralization                                                             1 (2%)                                             
      Necrosis                                                                   1 (2%)                                             
      Thrombosis                                                                 1 (2%)                                             
      Ventricle, Dilatation                            4 (8%)       1 (4%)                                                          
   Spinal Cord                                                     (1)                                                              
      Hemorrhage                                                    1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Larynx                                             (50)         (24)         (48)                                                
      Foreign Body                                     5 (10%)                   3 (6%)                                             
      Hemorrhage                                                    1 (4%)                                                          
      Inflammation, Chronic                            3 (6%)                                                                       
      Inflammation, Suppurative                       14 (28%)      6 (25%)     13 (27%)                                            
      Epithelium, Hyperplasia                                       1 (4%)                                                          
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   11                                                              
NTP Experiment-Test: 05095-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          EPINEPHRINE HCL                                      Date: 09/12/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 23:29:54  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     CONTROL      1.5MG/M3     5.0MG/M3                                               
                                                   MALE          MALE         MALE                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
   Lung                                               (50)         (29)         (49)                                                
      Foreign Body                                     1 (2%)                                                                       
      Hemorrhage                                       2 (4%)       2 (7%)       3 (6%)                                             
      Alveolar Epithelium, Hyperplasia                 2 (4%)       4 (14%)      1 (2%)                                             
      Alveolus, Edema                                  1 (2%)       1 (3%)                                                          
      Alveolus, Fibrosis                               1 (2%)                                                                       
      Alveolus, Infiltration Cellular, Histiocyte      6 (12%)      4 (14%)      2 (4%)                                             
      Alveolus, Inflammation, Suppurative              1 (2%)       1 (3%)       5 (10%)                                            
      Artery, Mediastinum, Inflammation                                          1 (2%)                                             
   Nose                                               (50)         (49)         (50)                                                
      Foreign Body                                     4 (8%)       5 (10%)     10 (20%)                                            
      Hemorrhage                                       1 (2%)                                                                       
      Inflammation, Suppurative                        8 (16%)      9 (18%)     17 (34%)                                            
      Necrosis                                         1 (2%)                                                                       
      Glands, Dilatation                              13 (26%)     19 (39%)     44 (88%)                                            
      Glands, Hyperplasia                              2 (4%)                                                                       
      Nasolacrimal Duct, Inflammation, Suppurative     2 (4%)       1 (2%)       1 (2%)                                             
      Olfactory Epithelium, Metaplasia                                           1 (2%)                                             
      Respiratory Epithelium, Hyperplasia                           5 (10%)     15 (30%)                                            
      Respiratory Epithelium, Hyperplasia, Focal       1 (2%)                                                                       
      Respiratory Epithelium, Metaplasia, Squamous                  3 (6%)       1 (2%)                                             
   Trachea                                            (50)         (24)         (49)                                                
      Inflammation, Chronic                                         1 (4%)                                                          
      Inflammation, Suppurative                        1 (2%)                                                                       
      Epithelium, Hyperplasia                                       1 (4%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (4)          (3)          (3)                                                 
      Cataract                                                      1 (33%)                                                         
      Lens, Cataract                                   4 (100%)     1 (33%)      3 (100%)                                           
   Harderian Gland                                    (1)                                                                           
      Hyperplasia                                      1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (26)         (49)                                                
      Infarct                                                       1 (4%)                                                          
      Nephropathy, Chronic                            49 (98%)     26 (100%)    49 (100%)                                           
      Pelvis, Hyperplasia                              1 (2%)                                                                       
      Pelvis, Inflammation, Suppurative                2 (4%)                                                                       
   Urinary Bladder                                    (50)         (22)         (49)                                                
      Hyperplasia                                      1 (2%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   12                                                              
NTP Experiment-Test: 05095-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          EPINEPHRINE HCL                                      Date: 09/12/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 23:29:54  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     CONTROL      1.5MG/M3     5.0MG/M3                                               
                                                   MALE          MALE         MALE                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Inflammation, Suppurative                        2 (4%)                                                                       
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   13                                                              
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