National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/1164

TR 380 Rat Pathology Tables

NTP Experiment-Test: 05095-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          EPINEPHRINE HCL                                      Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:26:06




       Facility:  Battelle Northwest

       Chemical CAS #:  55-31-2

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All






































                                                              Page   1

NTP Experiment-Test: 05095-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          EPINEPHRINE HCL                                      Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:26:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 4| 7| 6| 6| 7| 7| 7| 7| 7| 7| 2| 6| 7| 6| 7| 7| 7| 7| 7| 7| 4|             
                             DAY ON TEST   | 2| 2| 7| 2| 7| 2| 7| 8| 2| 2| 2| 2| 2| 2| 5| 3| 2| 2| 2| 2| 2| 2| 2| 2| 7|             
                                           | 9| 9| 1| 9| 6| 9| 0| 2| 9| 9| 9| 9| 9| 9| 8| 7| 9| 4| 9| 9| 9| 9| 9| 9| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    FEMALE                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  A  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                            1                                             |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                  2                                       |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  M  +|             
      Inflammation, Chronic                |                               3                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                               3                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                             2            |             
      Basophilic Focus                     |    2                 2     2  2  3  1           2     3     2  2         |             
      Clear Cell Focus                     |                                     X                                    |             
      Developmental Malformation           |                                     X                                    |             
      Eosinophilic Focus                   |                                  X                             X         |             
      Inflammation, Granulomatous          |    2           2           1  2  2  2           2     4     2  2  3      |             
      Necrosis                             |       3                                   3  3        4                  |             
      Bile Duct, Hyperplasia               | 4                          1                 2           2           1   |             
      Hepatocyte, Cytomegaly               |             3                                                            |             
      Hepatocyte, Vacuolization Cytoplasmic|             3     2                                      3        3      |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |       2  3                                      2                    2   |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                      2                                                   |             
      Karyomegaly                          |                      1                                                   |             
      Duct, Hyperplasia                    |                      2                                                   |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Epithelium, Hyperplasia              |                                                          2               |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |    2                    2     2  3              2                 2      |             
      Thrombosis                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05095-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          EPINEPHRINE HCL                                      Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:26:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 4| 7| 6| 6| 7| 7| 7| 7| 7| 7| 2| 6| 7| 6| 7| 7| 7| 7| 7| 7| 4|             
                             DAY ON TEST   | 2| 2| 7| 2| 7| 2| 7| 8| 2| 2| 2| 2| 2| 2| 5| 3| 2| 2| 2| 2| 2| 2| 2| 2| 7|             
                                           | 9| 9| 1| 9| 6| 9| 0| 2| 9| 9| 9| 9| 9| 9| 8| 7| 9| 4| 9| 9| 9| 9| 9| 9| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    FEMALE                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Myocardium, Hemorrhage               |                                                 2                        |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                  2     2                 2        2  2   |             
      Vacuolization Cytoplasmic            |                3  2              1     2        4        2        2  2   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   | 2                                                                        |             
      Hyperplasia                          |                1  2  2     1                                             |             
      Vacuolization Cytoplasmic            |       3                                                                  |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                                                          3               |             
      Pars Distalis, Hyperplasia           |                      1                                                   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ultimobranchial Cyst                 |                                                 X                        |             
      C-Cell, Hyperplasia                  |       2     2  2        2           2  2              1  2     4         |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                    X                     |             
      Hyperplasia                          |                                  2  3                                    |             
      Inflammation, Suppurative            |                                        4                                 |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 | X     X  X                                                               |             
      Inflammation, Chronic                |                                                       2                  |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Decidual Reaction                    |                                                                          |             
      Dilatation                           |                2        2                                         3      |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Metaplasia, Squamous                 |                                                                          |             
      Endometrium, Hyperplasia             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  M  +  +  +  +  +  M  +  +  +  +  +  M  M  M  +  M  M  M  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05095-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          EPINEPHRINE HCL                                      Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:26:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 4| 7| 6| 6| 7| 7| 7| 7| 7| 7| 2| 6| 7| 6| 7| 7| 7| 7| 7| 7| 4|             
                             DAY ON TEST   | 2| 2| 7| 2| 7| 2| 7| 8| 2| 2| 2| 2| 2| 2| 5| 3| 2| 2| 2| 2| 2| 2| 2| 2| 7|             
                                           | 9| 9| 1| 9| 6| 9| 0| 2| 9| 9| 9| 9| 9| 9| 8| 7| 9| 4| 9| 9| 9| 9| 9| 9| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    FEMALE                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
      Hematopoietic Cell Proliferation     |                      4                                                   |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                               X                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Galactocele                          |                               X                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                X  3           3        3     4              3            |             
      Congestion                           |                3                                                         |             
      Hemorrhage                           |       3           3                       4                              |             
      Ventricle, Dilatation                |                                              3                           |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |       2     1  2              1     2           2     2     2            |             
      Epithelium, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |             2                                            4               |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                         2              2                                 |             
      Alveolus, Inflammation, Suppurative  |                                  2     2                    2            |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                                                          |             
      Inflammation, Suppurative            |                                  2                                       |             
      Parasite Metazoan                    |                                                                          |             
      Glands, Dilatation                   |                                        1                 1               |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                               +                                          |             
      Acanthosis                           |                               4                                          |             
      Inflammation, Granulomatous          |                               4                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                         +                                      +         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05095-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          EPINEPHRINE HCL                                      Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:26:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 4| 7| 6| 6| 7| 7| 7| 7| 7| 7| 2| 6| 7| 6| 7| 7| 7| 7| 7| 7| 4|             
                             DAY ON TEST   | 2| 2| 7| 2| 7| 2| 7| 8| 2| 2| 2| 2| 2| 2| 5| 3| 2| 2| 2| 2| 2| 2| 2| 2| 7|             
                                           | 9| 9| 1| 9| 6| 9| 0| 2| 9| 9| 9| 9| 9| 9| 8| 7| 9| 4| 9| 9| 9| 9| 9| 9| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    FEMALE                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Atrophy                              |                                                                          |             
      Lens, Cataract                       |                         2                                      2         |             
                                            __________________________________________________________________________|             
   Lacrimal Gland                          |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                          X               |             
      Infarct                              |                                                                          |             
      Mineralization                       |                      2                                                   |             
      Nephropathy, Chronic                 | 2  3  3  2  1  4  2  2  2  3  4  3  2  3     2  2  2  3  3  3  2  1  3  2|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05095-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          EPINEPHRINE HCL                                      Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:26:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 5| 7| 6| 7| 7| 7| 5| 7| 7| 7|            |
                             DAY ON TEST   | 0| 2| 2| 2| 2| 1| 4| 9| 2| 2| 2| 2| 5| 2| 2| 7| 2| 7| 2| 2| 2| 8| 2| 1| 1|            |
                                           | 3| 9| 9| 9| 9| 4| 4| 3| 9| 9| 9| 9| 1| 9| 9| 7| 9| 1| 9| 9| 9| 2| 9| 5| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    FEMALE                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|  45        |
      Parasite Metazoan                    |          2                                                        2      |      3  1.7|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Parasite Metazoan                    |                                                          2           2   |      3  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|  49        |
      Parasite Metazoan                    |                                        X                                 |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|  45        |
      Inflammation, Chronic                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|  48        |
      Inflammation, Chronic                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                                      2   |      2  2.0|
      Basophilic Focus                     |    2     2  2  2  3     3  2  2  2                    2              2   |     21  2.1|
      Clear Cell Focus                     |          1                             2                                 |      3  1.5|
      Developmental Malformation           |                                     X                                    |      2     |
      Eosinophilic Focus                   |                                                                   2      |      3  2.0|
      Inflammation, Granulomatous          |       3  3  2                    2     2  3  2     2                     |     19  2.3|
      Necrosis                             | 4                 3                 3                                    |      7  3.3|
      Bile Duct, Hyperplasia               |       1              2                    2     2        2               |     10  1.9|
      Hepatocyte, Cytomegaly               |                                                                          |      1  3.0|
      Hepatocyte, Vacuolization Cytoplasmic| 2                 3  2              2                 2     3           4|     11  2.6|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                   +                                                      |   1        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Acinus, Atrophy                      |                         2                    1  3                        |      7  2.1|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            |                                                                          |      1  2.0|
      Karyomegaly                          |                                                                          |      1  1.0|
      Duct, Hyperplasia                    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acanthosis                           |                                                                         4|      1  4.0|
      Inflammation, Suppurative            |                                                    3                    4|      2  3.5|
      Ulcer                                |                                                    2                    4|      2  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Epithelium, Hyperplasia              |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   6                                                               
NTP Experiment-Test: 05095-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          EPINEPHRINE HCL                                      Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:26:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 5| 7| 6| 7| 7| 7| 5| 7| 7| 7|            |
                             DAY ON TEST   | 0| 2| 2| 2| 2| 1| 4| 9| 2| 2| 2| 2| 5| 2| 2| 7| 2| 7| 2| 2| 2| 8| 2| 1| 1|            |
                                           | 3| 9| 9| 9| 9| 4| 4| 3| 9| 9| 9| 9| 1| 9| 9| 7| 9| 1| 9| 9| 9| 2| 9| 5| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    FEMALE                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       |       1     2           2        2              2        2        2      |     13  2.0|
      Thrombosis                           |                      X                                      X            |      2     |
      Myocardium, Hemorrhage               |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |       2  2              2  2        2           3  2  2                  |     13  2.1|
      Vacuolization Cytoplasmic            | 2  1  2  3     2     2  2  2              2  1        2     4     2      |     21  2.1|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Focal                   |                                                                          |      1  2.0|
      Hyperplasia                          |          2                 2                    3                        |      7  1.9|
      Vacuolization Cytoplasmic            |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  M  +  M  +  +  M|  41        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Pars Distalis, Angiectasis           |                                           3              2               |      3  2.7|
      Pars Distalis, Hyperplasia           |                            2                                      2      |      3  1.7|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ultimobranchial Cyst                 |                                                                          |      1     |
      C-Cell, Hyperplasia                  |       3  3     4                       2  4     2           2        1   |     17  2.4|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Cyst                                 |                                                                X         |      2     |
      Hyperplasia                          |                         2                                3  2            |      5  2.4|
      Inflammation, Suppurative            |       4                 2        2     4                                 |      5  3.2|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |       X                             X           X              X         |      7     |
      Inflammation, Chronic                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Decidual Reaction                    |                      X                                                   |      1     |
      Dilatation                           |                                                                          |      3  2.3|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   7                                                               
NTP Experiment-Test: 05095-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          EPINEPHRINE HCL                                      Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:26:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 5| 7| 6| 7| 7| 7| 5| 7| 7| 7|            |
                             DAY ON TEST   | 0| 2| 2| 2| 2| 1| 4| 9| 2| 2| 2| 2| 5| 2| 2| 7| 2| 7| 2| 2| 2| 8| 2| 1| 1|            |
                                           | 3| 9| 9| 9| 9| 4| 4| 3| 9| 9| 9| 9| 1| 9| 9| 7| 9| 1| 9| 9| 9| 2| 9| 5| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    FEMALE                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Hemorrhage                           |                      4                                                   |      1  4.0|
      Inflammation, Suppurative            | 4                                                                        |      1  4.0|
      Metaplasia, Squamous                 | 3                                                                        |      1  3.0|
      Endometrium, Hyperplasia             |          2        2                                                      |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  M  +  M  +  +  +  +  +  +  M  M  +  +  +  +  +  M  +  +  +  +  +  +  +|  37        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis                             |                                        4                                 |      1  4.0|
      Hematopoietic Cell Proliferation     |                   4                          3                           |      3  3.7|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  49        |
      Galactocele                          |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Acanthosis                           |                                                                         4|      1  4.0|
      Inflammation, Chronic                |                                                                         2|      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression                          |                                  2                 3  2              4   |     10  3.0|
      Congestion                           |                                                                          |      1  3.0|
      Hemorrhage                           | 3                                   3  2                                 |      6  3.0|
      Ventricle, Dilatation                |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            |          3                             2           2        2            |     12  1.9|
      Epithelium, Hyperplasia              |          2                             1                                 |      2  1.5|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                                                          |      2  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   8                                                               
NTP Experiment-Test: 05095-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          EPINEPHRINE HCL                                      Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:26:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 5| 7| 6| 7| 7| 7| 5| 7| 7| 7|            |
                             DAY ON TEST   | 0| 2| 2| 2| 2| 1| 4| 9| 2| 2| 2| 2| 5| 2| 2| 7| 2| 7| 2| 2| 2| 8| 2| 1| 1|            |
                                           | 3| 9| 9| 9| 9| 4| 4| 3| 9| 9| 9| 9| 1| 9| 9| 7| 9| 1| 9| 9| 9| 2| 9| 5| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    FEMALE                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |                      2  3                 2                              |      5  2.2|
      Alveolus, Inflammation, Suppurative  |                                                                          |      3  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Foreign Body                         |                               2                                          |      1  2.0|
      Inflammation, Suppurative            |                                                                          |      1  2.0|
      Parasite Metazoan                    |                                              2                           |      1  2.0|
      Glands, Dilatation                   |                                        1              1                  |      4  1.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
      Acanthosis                           |                                                                          |      1  4.0|
      Inflammation, Granulomatous          |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Eye                                     |                            +     +                             +         |   5        |
      Atrophy                              |                            4                                             |      1  4.0|
      Lens, Cataract                       |                                  2                                       |      3  2.0|
                                            __________________________________________________________________________|____________|
   Lacrimal Gland                          |                                           +  +                       +   |   3        |
      Inflammation, Chronic                |                                           3  3                       2   |      3  2.7|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                                                          |      1     |
      Infarct                              | 4                                                                        |      1  4.0|
      Mineralization                       |                                                                          |      1  2.0|
      Nephropathy, Chronic                 | 2  2  2  3  2  3  3  2  2  3  2  2  2  3  3  1  3  2  2  2  2  1  3  3  2|     49  2.4|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  49        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   9                                                               
NTP Experiment-Test: 05095-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          EPINEPHRINE HCL                                      Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:26:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 1| 2| 3| 7| 3| 1| 3| 3| 3| 1| 1| 3| 3| 3| 3| 3| 2| 3| 3| 8|             
                                           | 1| 1| 1| 1| 1| 7| 4| 1| 9| 1| 7| 1| 1| 1| 7| 4| 1| 1| 1| 1| 1| 3| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    1.5MG/M3                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
     FEMALE                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |                +  +     +     +           +  +                 +        +|             
                                            __________________________________________________________________________|             
   Intestine Large                         |                +  +     +     +           +  +                 +        +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |                +  +     +     +           +  +                 +        +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |                +  +     +     +           +  +                 +        +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |                +  +     +     +           +  +                 +        +|             
                                            __________________________________________________________________________|             
   Intestine Small                         |                +  +     +     +           +  +                 +        +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |                +  +     +     +           +  +                 +        +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |                +  A     +     +           +  +                 +        +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |                +  +     +     +           +  +                 +        +|             
                                            __________________________________________________________________________|             
   Liver                                   |    +  +        +  +  +  +     +     +  +  +  +  +        +     +  +     +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     |                X        3           2                                    |             
      Basophilic Focus, Multiple           |                               3                                          |             
      Clear Cell Focus                     |                                     1                                    |             
      Developmental Malformation           |    X           X                    X        X  X                 X      |             
      Eosinophilic Focus                   |                                        3                                 |             
      Hyperplasia, Focal                   |                               3                                          |             
      Inflammation, Granulomatous          |       3                             2                          3         |             
      Necrosis                             |                                                                          |             
      Bile Duct, Hyperplasia               |                      2  2           2     2                    1        2|             
      Hepatocyte, Vacuolization Cytoplasmic|                   2     3                    2                           |             
                                            __________________________________________________________________________|             
   Pancreas                                |                +  +     +     +           +  +                 +        +|             
      Acinus, Atrophy                      |                                           2  2                          4|             
                                            __________________________________________________________________________|             
   Salivary Glands                         |                +  +     +     +           +  +                 +        +|             
                                            __________________________________________________________________________|             
   Stomach                                 |                +  +     +     +           +  +                 +        +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |                +  +     +     +           +  +                 +        +|             
      Acanthosis                           |                                                                          |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |                +  +     +     +           +  +                 +        +|             
      Mineralization                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |                +  +     +     +           +  +                 +        +|             
      Cardiomyopathy                       |                2  2                          2                           |             
      Mineralization                       |                                                                          |             
      Artery, Mineralization               |                                                                          |             
      Myocardium, Necrosis                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |       +        +  +     +     +           +  +                 +        +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |       +        +  +     +     +           +  +                 +        +|             
      Hemorrhage                           |                                                                         4|             
      Necrosis                             |                   4                                                      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  10                                                               
NTP Experiment-Test: 05095-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          EPINEPHRINE HCL                                      Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:26:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 1| 2| 3| 7| 3| 1| 3| 3| 3| 1| 1| 3| 3| 3| 3| 3| 2| 3| 3| 8|             
                                           | 1| 1| 1| 1| 1| 7| 4| 1| 9| 1| 7| 1| 1| 1| 7| 4| 1| 1| 1| 1| 1| 3| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    1.5MG/M3                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
     FEMALE                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Vacuolization Cytoplasmic            |                   3           3           2  3                           |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |       +        +  +     +     +           +  +                 +        +|             
      Hyperplasia                          |                                                                2         |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |                +  +     +     +           +  +                 +        +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |                +  +     +     +           +  +                 +        +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +     +  +  +  +  +     +     +  +  +  +  +  +  +  +     +        +|             
      Cyst                                 |                                                                          |             
      Pars Distalis, Hyperplasia, Focal    |                                                                          |             
      Pars Distalis, Hyperplasia           |                                           2                              |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |                +  +     +     +           +  +                 +        +|             
      Ultimobranchial Cyst                 |                                                                          |             
      C-Cell, Hyperplasia                  |                3        2                 2  1                           |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |                +  +     M     +        +  +  +                 +  +     M|             
      Hyperplasia                          |                                        3     4                           |             
      Inflammation, Suppurative            |                                              4                    4      |             
                                            __________________________________________________________________________|             
   Ovary                                   |                +  +     +  +  +           +  +                 +        +|             
                                            __________________________________________________________________________|             
   Uterus                                  |             +  +  +     +     +        +  +  +                 +        +|             
      Dilatation                           |             3                                                            |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Suppurative            |                                                                4         |             
      Prolapse                             |                                                                4         |             
      Endometrium, Hyperplasia             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |                +  +     +     +           +  +                 +        +|             
      Fibrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +              +  +     +     +           +  +                 +        +|             
      Mediastinal, Hyperplasia             | 3                                                                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   |                +  +     +     +           +  +                 +        +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |                M  +     M     +           +  +                 M        +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  |                +  +  +  +     +        +  +  +           +  +  +        +|             
      Developmental Malformation           |                                                             X            |             
      Fibrosis                             |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                3         |             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  |                +  +     +     +           +  +                 +        M|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  11                                                               
NTP Experiment-Test: 05095-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          EPINEPHRINE HCL                                      Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:26:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 1| 2| 3| 7| 3| 1| 3| 3| 3| 1| 1| 3| 3| 3| 3| 3| 2| 3| 3| 8|             
                                           | 1| 1| 1| 1| 1| 7| 4| 1| 9| 1| 7| 1| 1| 1| 7| 4| 1| 1| 1| 1| 1| 3| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    1.5MG/M3                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
     FEMALE                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    +           +  +     +     +     +     +  +                 +  +     +|             
      Galactocele                          |                         X                                                |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    |                +  +  +  +     +           +  +                 +        +|             
      Inflammation, Suppurative            |                         2                                                |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |                +  +     +     +           +  +                 +        +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                     +                                    |             
      Diaphragm, Developmental Malformation|                                     X                                    |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |                +  +     +     +           +  +                 +        +|             
      Compression                          |                         3                    3                           |             
      Ventricle, Dilatation                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  |                +  +     +     +           +  +                 +        +|             
      Foreign Body                         |                                                                          |             
      Inflammation, Chronic                |                                              1                           |             
      Inflammation, Suppurative            |                   3                                                      |             
      Mineralization                       |                                                                          |             
      Epithelium, Hyperplasia              |                   2                                                      |             
                                            __________________________________________________________________________|             
   Lung                                    |       +        +  +     +     +        +  +  +                 +        +|             
      Foreign Body                         |                   4                                                      |             
      Mineralization                       |                                                                          |             
      Alveolus, Edema                      |                   4                                                      |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                3        2     2        4                       2         |             
      Alveolus, Inflammation, Suppurative  |                   4                                                      |             
      Bronchiole, Inflammation, Suppurative|                   4                                                      |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |             4                                                            |             
      Foreign Body                         |             2                    2              2                        |             
      Inflammation, Suppurative            | 1           3     4              3                 3        1            |             
      Glands, Dilatation                   |    1        4  1     2  2                    1  1                    1  2|             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |                                                       2                  |             
      Respiratory Epithelium, Hyperplasia  | 2           2  1                 2                    1              1  3|             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        | 1                                                                        |             
                                            __________________________________________________________________________|             
   Trachea                                 |                +  +     +     +           +  +                 +        +|             
      Inflammation, Suppurative            |                   3                                                      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  12                                                               
NTP Experiment-Test: 05095-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          EPINEPHRINE HCL                                      Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:26:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 1| 2| 3| 7| 3| 1| 3| 3| 3| 1| 1| 3| 3| 3| 3| 3| 2| 3| 3| 8|             
                                           | 1| 1| 1| 1| 1| 7| 4| 1| 9| 1| 7| 1| 1| 1| 7| 4| 1| 1| 1| 1| 1| 3| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    1.5MG/M3                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
     FEMALE                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                         +  +                 +                          +|             
      Lens, Cataract                       |                         2  2                 2                          2|             
                                            __________________________________________________________________________|             
   Lacrimal Gland                          |                                              +                           |             
      Inflammation, Chronic                |                                              3                           |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +              +  +     +     +           +  +                 +        +|             
      Mineralization                       |                                                                          |             
      Nephropathy, Chronic                 | 4              1  2     4     1           2  2                 2        2|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |                +  +     +     +           +  +                 +        +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  13                                                               
NTP Experiment-Test: 05095-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          EPINEPHRINE HCL                                      Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:26:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 5| 7| 7| 7| 1| 5| 7| 5| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 6|            |
                             DAY ON TEST   | 5| 3| 2| 3| 3| 2| 2| 3| 1| 5| 3| 3| 3| 3| 3| 7| 3| 3| 3| 1| 3| 3| 5| 2| 5|            |
                                           | 3| 1| 8| 1| 1| 0| 6| 5| 4| 3| 0| 1| 1| 1| 1| 9| 1| 1| 1| 4| 1| 1| 3| 0| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    1.5MG/M3                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
     FEMALE                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +     +        +  +  +  +  +  +              +           +        +  +  +|  21        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +     +        +  A  +  +  +  +              +           +        +  +  +|  20        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | M     +        +  M  +  +  +  M              +           +        +  +  A|  17        |
      Parasite Metazoan                    |                         X                                                |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +     +        +  A  +  +  +  +              +           +        +  +  +|  20        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +     +        +  A  +  +  +  +              +           +        +  +  +|  20        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +     +        +  A  +  +  +  +              +           +        +  +  +|  20        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +     +        +  A  +  +  +  +              +           +        +  +  +|  20        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +     +        +  A  +  +  +  +              +           +        +  +  A|  18        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +     +        +  A  +  +  +  +              +           +        +  +  A|  19        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +     +        +  +  +  +  +  +              +           +  +  +  +  +  +|  31        |
      Angiectasis                          |                                              4                           |      1  4.0|
      Basophilic Focus                     |                         4                    3           3     2  3  3   |      9  2.9|
      Basophilic Focus, Multiple           |                                                                          |      1  3.0|
      Clear Cell Focus                     |                                                                4         |      2  2.5|
      Developmental Malformation           |                            X                 X                          X|      9     |
      Eosinophilic Focus                   |                                                                          |      1  3.0|
      Hyperplasia, Focal                   |                                                                          |      1  3.0|
      Inflammation, Granulomatous          |       3                    2                                   2         |      6  2.5|
      Necrosis                             |                3                                               2  2      |      3  2.3|
      Bile Duct, Hyperplasia               |                         2  2                 2                           |      9  1.9|
      Hepatocyte, Vacuolization Cytoplasmic|       3                    2                                4     3      |      7  2.7|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +     +        +  +  +  +  +  +              +           +        +  +  +|  21        |
      Acinus, Atrophy                      | 3              2     3                       2                           |      7  2.6|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +     +        +  +  +  +  +  +              +           +        +  +  +|  21        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +     +        +  +  +  +  +  +              +           +        +  +  +|  21        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +     +        +  +  +  +  +  +              +           +        +  +  +|  21        |
      Acanthosis                           |                            2                                             |      1  2.0|
      Ulcer                                |                            2                                             |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +     +        +  +  +  +  +  +              +           +        +  +  +|  21        |
      Mineralization                       |                                                                         4|      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +     +        +  +  +  +  +  +              +           +        +  +  +|  21        |
      Cardiomyopathy                       |                2     2                                               2   |      6  2.0|
      Mineralization                       |                                                                         4|      1  4.0|
      Artery, Mineralization               |                                                                         4|      1  4.0|
      Myocardium, Necrosis                 |                                                                         4|      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  14                                                               
NTP Experiment-Test: 05095-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          EPINEPHRINE HCL                                      Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:26:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 5| 7| 7| 7| 1| 5| 7| 5| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 6|            |
                             DAY ON TEST   | 5| 3| 2| 3| 3| 2| 2| 3| 1| 5| 3| 3| 3| 3| 3| 7| 3| 3| 3| 1| 3| 3| 5| 2| 5|            |
                                           | 3| 1| 8| 1| 1| 0| 6| 5| 4| 3| 0| 1| 1| 1| 1| 9| 1| 1| 1| 4| 1| 1| 3| 0| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    1.5MG/M3                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
     FEMALE                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +     +        +  +  +  +  +  +              +           +  +     +  +  +|  23        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +     +        +  +  +  +  +  +              +           +  +     +  +  +|  23        |
      Hemorrhage                           |                                                                          |      1  4.0|
      Necrosis                             |                                                                         4|      2  4.0|
      Vacuolization Cytoplasmic            | 2     4                                      3           2  2            |      9  2.7|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +     +        +  M  +  +  +  +              +           +  +     +  +  +|  22        |
      Hyperplasia                          |       2                                                                  |      2  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +     +        +  +  +  +  +  +              +           +  +     +  +  +|  22        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +     +        +  +  M  +  +  +              +           +        +  +  +|  20        |
      Hyperplasia                          |                                                                         3|      1  3.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +     +  +     +  +  +  +  +  +  +     +     +  +  +  +  +        +  +  +|  38        |
      Cyst                                 |       X  X                             X                                 |      3     |
      Pars Distalis, Hyperplasia, Focal    | 2                                                                        |      1  2.0|
      Pars Distalis, Hyperplasia           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +     +        +  +  +  +  +  +              +           +        +  +  +|  21        |
      Ultimobranchial Cyst                 |                      X                                                   |      1     |
      C-Cell, Hyperplasia                  |       1                    1                 2           2        1      |      9  1.7|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +     +        +  +  +  +  +  +              +     +     M        +  +  +|  21        |
      Hyperplasia                          |                                                                          |      2  3.5|
      Inflammation, Suppurative            |                                                                   3      |      3  3.7|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +     +        +  +  +  +  +  +              +           +        +  +  +|  22        |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +     +        +  +  +  +  +  +  +           +     +     +        +  +  +|  25        |
      Dilatation                           |                                                                          |      1  3.0|
      Hemorrhage                           |                               4                                          |      1  4.0|
      Inflammation, Suppurative            |                               2                                          |      2  3.0|
      Prolapse                             |                                                                          |      1  4.0|
      Endometrium, Hyperplasia             |                               3                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +     +        +  +  +  +  +  +              +           +        +  +  +|  21        |
      Fibrosis                             |                                                                      3   |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +     +        +  +  +  +  +  +              +           +        +  +  +|  22        |
      Mediastinal, Hyperplasia             |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  15                                                               
NTP Experiment-Test: 05095-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          EPINEPHRINE HCL                                      Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:26:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 5| 7| 7| 7| 1| 5| 7| 5| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 6|            |
                             DAY ON TEST   | 5| 3| 2| 3| 3| 2| 2| 3| 1| 5| 3| 3| 3| 3| 3| 7| 3| 3| 3| 1| 3| 3| 5| 2| 5|            |
                                           | 3| 1| 8| 1| 1| 0| 6| 5| 4| 3| 0| 1| 1| 1| 1| 9| 1| 1| 1| 4| 1| 1| 3| 0| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    1.5MG/M3                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
     FEMALE                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +     M        M  +  M  +  +  +              +           +        +  +  +|  18        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +     +        +  +  +  +  +  +              +           +        M  +  +|  17        |
      Hyperplasia                          |       3                                                                  |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +     +        +  +  +  +  +  +              +           +  +     +  +  +|  26        |
      Developmental Malformation           |                                                                          |      1     |
      Fibrosis                             |                                                                      3  4|      2  3.5|
      Hematopoietic Cell Proliferation     |                                                                          |      1  3.0|
      Pigmentation                         |                                                                         4|      1  4.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +     M        +  +  +  +  +  +              +           +        +  +  +|  19        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +     +  +  +  +  +  +  +           +           +  +     +  +  +|  28        |
      Galactocele                          |                                                                          |      1     |
      Hyperplasia                          |                2                                                         |      1  2.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +     +        +  +  +  +  +  +              +           +        +  +  +|  22        |
      Inflammation, Suppurative            |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +     +        +  +  +  +  +  +              +           +        +  +  +|  21        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
      Diaphragm, Developmental Malformation|                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +     +        +  +  +  +  +  +              +           +        +  +  +|  21        |
      Compression                          |                3           4                             4        3      |      6  3.3|
      Ventricle, Dilatation                |                                                                   2      |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +     +        +  +  +  +  +  +              +           +        +  +  +|  21        |
      Foreign Body                         |                                                          2               |      1  2.0|
      Inflammation, Chronic                |                2                                                         |      2  1.5|
      Inflammation, Suppurative            |                      3                                   2        1      |      4  2.3|
      Mineralization                       |                                                                         4|      1  4.0|
      Epithelium, Hyperplasia              |                      2                                                   |      2  2.0|
                                            __________________________________________________________________________|____________|
   Lung                                    | +     +        +  +  +  +  +  +              +           +        +  +  +|  23        |
      Foreign Body                         |                                                                          |      1  4.0|
      Mineralization                       |                                                                         4|      1  4.0|
      Alveolus, Edema                      |                                                                          |      1  4.0|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  16                                                               
NTP Experiment-Test: 05095-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          EPINEPHRINE HCL                                      Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:26:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 5| 7| 7| 7| 1| 5| 7| 5| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 6|            |
                             DAY ON TEST   | 5| 3| 2| 3| 3| 2| 2| 3| 1| 5| 3| 3| 3| 3| 3| 7| 3| 3| 3| 1| 3| 3| 5| 2| 5|            |
                                           | 3| 1| 8| 1| 1| 0| 6| 5| 4| 3| 0| 1| 1| 1| 1| 9| 1| 1| 1| 4| 1| 1| 3| 0| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    1.5MG/M3                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
     FEMALE                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
           Histiocyte                      |                      3                                               3   |      7  2.7|
      Alveolus, Inflammation, Suppurative  |                                                                          |      1  4.0|
      Bronchiole, Inflammation, Suppurative|                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Dilatation                           |                                                                          |      1  4.0|
      Foreign Body                         |                                        2     3                           |      5  2.2|
      Inflammation, Suppurative            |    2                                   3     3              2            |     10  2.5|
      Glands, Dilatation                   |       2        2           2     1           1                          2|     15  1.7|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |                                                                          |      1  2.0|
      Respiratory Epithelium, Hyperplasia  |                               2  1     3     2                    1      |     12  1.8|
      Respiratory Epithelium, Metaplasia,  |                                                                          |            |
           Squamous                        |                                        3                                 |      2  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +     +        +  +  +  +  +  +              +           +        +  +  +|  21        |
      Inflammation, Suppurative            |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                              +  +              +         |   7        |
      Lens, Cataract                       |                                              3  2              2         |      7  2.1|
                                            __________________________________________________________________________|____________|
   Lacrimal Gland                          |                                                                          |   1        |
      Inflammation, Chronic                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |       +                                                                  |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +     +        +  +  +  +  +  +              +  +        +        +  +  +|  23        |
      Mineralization                       |                                                                         4|      1  4.0|
      Nephropathy, Chronic                 | 2     2        3     2  2  2                 2  3        3        3  2  4|     21  2.4|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +     +        +  +  +  +  +  +              +           +        +  +  +|  21        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  17                                                               
NTP Experiment-Test: 05095-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          EPINEPHRINE HCL                                      Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:26:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 6| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 6| 7| 5| 3| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 1| 5| 3| 3| 3| 8| 3| 3| 3| 5| 3| 1| 3| 2| 3| 7| 5| 3| 4| 3| 1| 3| 3|             
                                           | 0| 0| 5| 4| 7| 0| 0| 1| 0| 0| 0| 7| 0| 5| 0| 2| 0| 2| 6| 0| 4| 0| 5| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    5.0MG/M3                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
     FEMALE                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  A  +  +  A  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  A  +  +  +  +  +  +  A  +  +  +  A  +  +  A  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
      Artery, Inflammation                 |                      4                                                   |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  A  +  +  +  +  +  +  A  +  +  +  A  +  +  A  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Parasite Metazoan                    |                                                                   2      |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  A  +  +  A  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  A  +  +  +  +  +  +  A  +  +  +  A  +  +  A  +  +  +  +  +  +|             
      Muscularis, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  A  +  +  +  +  +  +  A  +  +  +  A  +  +  A  +  +  +  +  +  +|             
      Artery, Inflammation                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  A  +  +  +  +  +  +  A  +  +  +  A  +  +  A  +  +  +  +  +  +|             
      Artery, Inflammation                 |                      4                                                   |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  A  +  +  +  +  +  +  A  +  +  +  A  +  +  A  +  +  +  +  +  +|             
      Artery, Inflammation                 |                      4                                                   |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  A  +  +  A  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     | 2  2           2                    2  2  2     2        1     2     2   |             
      Clear Cell Focus                     | 2                                   2                                    |             
      Developmental Malformation           |                         X           X  X                             X   |             
      Eosinophilic Focus                   |                                                                          |             
      Eosinophilic Focus, Multiple         |                         X                                                |             
      Hematopoietic Cell Proliferation     |                      3                                         2         |             
      Inflammation, Granulomatous          | 2              3  3  4        3     1  3  2              2               |             
      Inflammation, Suppurative            |    2                                               3                     |             
      Mixed Cell Focus                     |                         X                                                |             
      Necrosis                             |       2                                                     3            |             
      Artery, Inflammation                 |                      4                                                   |             
      Artery, Mineralization               |                                                                          |             
      Bile Duct, Hyperplasia               |          2     2        2                                         2      |             
      Hepatocyte, Vacuolization Cytoplasmic|          2  3                                      3        3            |             
                                            __________________________________________________________________________|             
   Mesentery                               |                               +                                          |             
      Inflammation, Chronic                |                               4                                          |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  A  +  +  M  +  +  +  +  +  +|             
      Fibrosis                             |       3                                                                  |             
      Acinus, Atrophy                      |                2                          2                              |             
      Artery, Inflammation                 |                      4                                                   |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +  +  +  +  +  +|             
      Acanthosis                           |       3     2        3        4                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  18                                                               
NTP Experiment-Test: 05095-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          EPINEPHRINE HCL                                      Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:26:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 6| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 6| 7| 5| 3| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 1| 5| 3| 3| 3| 8| 3| 3| 3| 5| 3| 1| 3| 2| 3| 7| 5| 3| 4| 3| 1| 3| 3|             
                                           | 0| 0| 5| 4| 7| 0| 0| 1| 0| 0| 0| 7| 0| 5| 0| 2| 0| 2| 6| 0| 4| 0| 5| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    5.0MG/M3                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
     FEMALE                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Developmental Malformation           |                      X                                                   |             
      Hyperkeratosis                       |       2                                                                  |             
      Inflammation, Suppurative            |       3     2        3        3                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Suppurative            |                                                    2                     |             
      Mineralization                       |                                  4                                       |             
      Artery, Inflammation                 |                      4                                                   |             
      Epithelium, Hyperplasia              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1  1           2     2  2  2     3  2     2                          2   |             
      Mineralization                       |                                  4                                       |             
      Thrombosis                           |       X                                            3                 X   |             
      Artery, Inflammation                 |                      3                                                   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  A  +  +  A  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  A  +  +  A  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Hemorrhage                           |                                                 2                        |             
      Hyperplasia                          |                                     2                                    |             
      Necrosis                             |                                                    2                     |             
      Thrombosis                           |                                                                          |             
      Vacuolization Cytoplasmic            | 2     2                       3                                2  2      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  A  +  +  A  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  A  +  +  M  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  M  +  +  M  +  +  +|             
      Hyperplasia                          |                      4                                                  1|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +  +  +  +  +  +|             
      Cyst                                 |                                                    X                     |             
      Pars Distalis, Angiectasis           |                      2                                                   |             
      Pars Distalis, Hyperplasia           |                         2  2        2                                    |             
      Pars Intermedia, Angiectasis         |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  A  +  +  M  +  +  +  +  +  +|             
      Ultimobranchial Cyst                 |                                                                          |             
      C-Cell, Hyperplasia                  | 2        4     2                    1           1        1     3  4      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  19                                                               
NTP Experiment-Test: 05095-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          EPINEPHRINE HCL                                      Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:26:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 6| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 6| 7| 5| 3| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 1| 5| 3| 3| 3| 8| 3| 3| 3| 5| 3| 1| 3| 2| 3| 7| 5| 3| 4| 3| 1| 3| 3|             
                                           | 0| 0| 5| 4| 7| 0| 0| 1| 0| 0| 0| 7| 0| 5| 0| 2| 0| 2| 6| 0| 4| 0| 5| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    5.0MG/M3                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
     FEMALE                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  M  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Metaplasia, Squamous                 |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  M  +  +  A  +  +  +  +  +  +|             
      Cyst                                 |          X           X                                                   |             
      Inflammation, Chronic                |                      4                                                   |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +  +  +  +  +  +|             
      Dilatation                           |             2                                                            |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                    +                     |             
      Neutrophilia                         |                                                    4                     |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  A  +  +  A  +  +  +  +  +  +|             
      Hyperplasia                          |                                           3                              |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  A  +  +  M  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  M  +  +  A  +  +  +  +  +  +|             
      Hyperplasia                          |                      3                                                   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  A  +  +  A  +  +  +  +  +  +|             
      Fibrosis                             |          4              4                                                |             
      Hematopoietic Cell Proliferation     |                      3                    3                    4         |             
      Infarct                              |          2                                                               |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                         +                                                |             
      Diaphragm, Developmental Malformation|                         X                                                |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
      Compression                          |          3     2                                3                    3   |             
      Thrombosis                           |                                                                          |             
      Ventricle, Dilatation                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  20                                                               
NTP Experiment-Test: 05095-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          EPINEPHRINE HCL                                      Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:26:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 6| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 6| 7| 5| 3| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 1| 5| 3| 3| 3| 8| 3| 3| 3| 5| 3| 1| 3| 2| 3| 7| 5| 3| 4| 3| 1| 3| 3|             
                                           | 0| 0| 5| 4| 7| 0| 0| 1| 0| 0| 0| 7| 0| 5| 0| 2| 0| 2| 6| 0| 4| 0| 5| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    5.0MG/M3                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
     FEMALE                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  M  +  +  A  +  +  +  +  +  +|             
      Foreign Body                         |          2                                                               |             
      Inflammation, Chronic                |                      3                    2     2        1               |             
      Inflammation, Suppurative            |    1     2     2  3           2        1                       2  1  3   |             
      Epithelium, Hyperplasia              |                   2                                                      |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +  +  +  +  +  +|             
      Foreign Body                         |                2                                                         |             
      Inflammation, Granulomatous          |                4                                                         |             
      Mineralization                       |                                  4                                       |             
      Alveolar Epithelium, Hyperplasia     |                                                 2        1               |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                         3                       2           3     2      |             
      Alveolus, Inflammation, Suppurative  |                   2                 1     2     2                        |             
      Artery, Inflammation                 |                      4                                                   |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  A  +  +  A  +  +  +  +  +  +|             
      Foreign Body                         |                                                                   2      |             
      Inflammation, Chronic                |                   2                                                      |             
      Inflammation, Suppurative            |                                                                   4     2|             
      Glands, Dilatation                   | 1  2  1  2  2  2  2  1     2  1     2  2  1     2  1     2  2  2  3  2   |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |                                                                          |             
      Respiratory Epithelium, Hyperplasia  |          2              1  2              1                 2  1        1|             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |                                                                   3     2|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  A  +  +  A  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                               +                                          |             
      Lens, Cataract                       |                               2                                          |             
                                            __________________________________________________________________________|             
   Lacrimal Gland                          |                                        +                                 |             
      Degeneration                         |                                        3                                 |             
      Inflammation, Chronic                |                                        3                                 |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +  +  +  +  +  +|             
      Mineralization                       |                                  4     2                                 |             
      Nephropathy, Chronic                 | 3  3  2  3  3  4  2  4  2  2  4     2  3  2     3  2     2  2  2  4  3  3|             
      Pelvis, Dilatation                   |                                  4                                       |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  A  +  +  A  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  21                                                               
NTP Experiment-Test: 05095-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          EPINEPHRINE HCL                                      Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:26:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7|            |
                             DAY ON TEST   | 3| 3| 6| 2| 3| 8| 3| 3| 3| 3| 2| 3| 3| 7| 3| 3| 3| 3| 2| 3| 7| 2| 3| 6| 3|            |
                                           | 0| 0| 2| 2| 0| 2| 0| 0| 0| 0| 7| 0| 0| 9| 0| 0| 0| 0| 5| 0| 9| 0| 0| 5| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    5.0MG/M3                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
     FEMALE                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A  +  +  +  +  +  +|  44        |
      Parasite Metazoan                    |                                                                2         |      1  2.0|
      Artery, Inflammation                 |                                                                      4   |      2  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|  45        |
      Hemorrhage                           |                   2                                                      |      1  2.0|
      Parasite Metazoan                    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A  +  +  +  +  +  +|  44        |
      Muscularis, Hyperplasia              |                      2                                                   |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A  +  +  +  +  +  +|  44        |
      Artery, Inflammation                 |                                                                      4   |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A  +  +  +  +  +  +|  44        |
      Artery, Inflammation                 |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A  +  +  +  +  +  +|  44        |
      Artery, Inflammation                 |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Angiectasis                          |                            1                                4            |      2  2.5|
      Basophilic Focus                     | 3     2     2  1  2  2     4     1  2           2  2                    2|     22  2.0|
      Clear Cell Focus                     |                                                                         2|      3  2.0|
      Developmental Malformation           |                                           X                             X|      6     |
      Eosinophilic Focus                   |                                                 3                        |      1  3.0|
      Eosinophilic Focus, Multiple         |                                                                          |      1     |
      Hematopoietic Cell Proliferation     |                                                                          |      2  2.5|
      Inflammation, Granulomatous          |       2        2  3  2  1        2     2              2  2  3     3     2|     21  2.3|
      Inflammation, Suppurative            |                                                                          |      2  2.5|
      Mixed Cell Focus                     |                                                                          |      1     |
      Necrosis                             |                               4                                          |      3  3.0|
      Artery, Inflammation                 |                                                                          |      1  4.0|
      Artery, Mineralization               |                                                                      4   |      1  4.0|
      Bile Duct, Hyperplasia               |    2  2                             2                          1         |      8  1.9|
      Hepatocyte, Vacuolization Cytoplasmic| 2     2  3  2                 4                       3     4            |     11  2.8|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                          +               |   2        |
      Inflammation, Chronic                |                                                                          |      1  4.0|
      Necrosis                             |                                                          4               |      1  4.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Fibrosis                             |                                                                          |      1  3.0|
      Acinus, Atrophy                      |    3  2        2  2  2           2  2  3                                2|     11  2.2|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  22                                                               
NTP Experiment-Test: 05095-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          EPINEPHRINE HCL                                      Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:26:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7|            |
                             DAY ON TEST   | 3| 3| 6| 2| 3| 8| 3| 3| 3| 3| 2| 3| 3| 7| 3| 3| 3| 3| 2| 3| 7| 2| 3| 6| 3|            |
                                           | 0| 0| 2| 2| 0| 2| 0| 0| 0| 0| 7| 0| 0| 9| 0| 0| 0| 0| 5| 0| 9| 0| 0| 5| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    5.0MG/M3                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
     FEMALE                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Artery, Inflammation                 |                                                                      4   |      2  4.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Acanthosis                           |                                                                          |      4  3.0|
      Developmental Malformation           |                                                                          |      1     |
      Hyperkeratosis                       |                                                                          |      1  2.0|
      Inflammation, Suppurative            |                                                                          |      4  2.8|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|  47        |
      Inflammation, Chronic                |                               3                                          |      1  3.0|
      Inflammation, Suppurative            |                                                                          |      1  2.0|
      Mineralization                       |                                                                      4   |      2  4.0|
      Artery, Inflammation                 |                                                                          |      1  4.0|
      Epithelium, Hyperplasia              |                            2                                             |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cardiomyopathy                       | 2           2           2     2  2                 2  2        2  2     2|     20  2.0|
      Mineralization                       |                                                                      4   |      2  4.0|
      Thrombosis                           |                               X                                          |      4  3.0|
      Artery, Inflammation                 |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Angiectasis                          | 3                                                                        |      1  3.0|
      Hemorrhage                           |                               2                                          |      2  2.0|
      Hyperplasia                          | 3  3           2                                   2        2        2  2|      8  2.3|
      Necrosis                             |                                                                          |      1  2.0|
      Thrombosis                           |                         X                                                |      1     |
      Vacuolization Cytoplasmic            |    3  2     2  2        3  2  3        2  3     3  3           2         |     17  2.4|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Hyperplasia                          | 2     2                       4                                   1      |      4  2.3|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +|  44        |
      Hyperplasia                          |    3                                                           2     2   |      5  2.4|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +|  47        |
      Cyst                                 |                                                                          |      1     |
      Pars Distalis, Angiectasis           |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  23                                                               
NTP Experiment-Test: 05095-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          EPINEPHRINE HCL                                      Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:26:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7|            |
                             DAY ON TEST   | 3| 3| 6| 2| 3| 8| 3| 3| 3| 3| 2| 3| 3| 7| 3| 3| 3| 3| 2| 3| 7| 2| 3| 6| 3|            |
                                           | 0| 0| 2| 2| 0| 2| 0| 0| 0| 0| 7| 0| 0| 9| 0| 0| 0| 0| 5| 0| 9| 0| 0| 5| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    5.0MG/M3                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
     FEMALE                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Pars Distalis, Hyperplasia           |                                                                          |      3  2.0|
      Pars Intermedia, Angiectasis         |                                        2                                 |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Ultimobranchial Cyst                 |                                                          X               |      1     |
      C-Cell, Hyperplasia                  |                      1  4                       3                        |     11  2.4|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Hyperplasia                          |                                  2                                       |      1  2.0|
      Inflammation, Suppurative            |                         3     4                       3           4      |      4  3.5|
      Metaplasia, Squamous                 |                                                                   4      |      1  4.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Cyst                                 |          X                 X                          X                  |      5     |
      Inflammation, Chronic                |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Dilatation                           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Vagina                                  |          +        +                                                      |   2        |
      Inflammation, Suppurative            |                   3                                                      |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |   1        |
      Neutrophilia                         |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Hyperplasia                          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  M  +  +  +  +  +  +  +  +  M  M  M  +  +  M  +  +  +  +  +  M  M|  39        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
      Hyperplasia                          |                                                             3            |      2  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Fibrosis                             |                                  3                                       |      3  3.7|
      Hematopoietic Cell Proliferation     |                   4                                               3      |      5  3.4|
      Infarct                              |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  24                                                               
NTP Experiment-Test: 05095-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          EPINEPHRINE HCL                                      Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:26:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7|            |
                             DAY ON TEST   | 3| 3| 6| 2| 3| 8| 3| 3| 3| 3| 2| 3| 3| 7| 3| 3| 3| 3| 2| 3| 7| 2| 3| 6| 3|            |
                                           | 0| 0| 2| 2| 0| 2| 0| 0| 0| 0| 7| 0| 0| 9| 0| 0| 0| 0| 5| 0| 9| 0| 0| 5| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    5.0MG/M3                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
     FEMALE                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Inflammation, Suppurative            |                                                                   2      |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
      Diaphragm, Developmental Malformation|                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Compression                          |             2                          2        3     2     4            |      9  2.7|
      Thrombosis                           |             2                                                            |      1  2.0|
      Ventricle, Dilatation                |                                                             4            |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Foreign Body                         |             2  2     2  2                                                |      5  2.0|
      Inflammation, Chronic                |                                                                          |      4  2.0|
      Inflammation, Suppurative            | 2  1        2  2     2  1                                2  3            |     17  1.9|
      Epithelium, Hyperplasia              |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Foreign Body                         |                                                                          |      1  2.0|
      Inflammation, Granulomatous          |                                                                          |      1  4.0|
      Mineralization                       |                                                                      4   |      2  4.0|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      2  1.5|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |                      2                                            3      |      6  2.5|
      Alveolus, Inflammation, Suppurative  |                                  3                                       |      5  2.0|
      Artery, Inflammation                 |                                  4                                       |      2  4.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|  46        |
      Foreign Body                         |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Inflammation, Suppurative            | 2                          1                             1           2   |      6  2.0|
      Glands, Dilatation                   |          2  1  2  1  2     2        2  2  3  2     2     2  2  3  2  2  1|     37  1.8|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |       2                                                                  |      1  2.0|
      Respiratory Epithelium, Hyperplasia  |       1     1     1           2                          2     2         |     13  1.5|
      Respiratory Epithelium, Metaplasia,  |                                                                          |            |
           Squamous                        |                                                                      2   |      3  2.3|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  25                                                               
NTP Experiment-Test: 05095-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          EPINEPHRINE HCL                                      Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:26:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7|            |
                             DAY ON TEST   | 3| 3| 6| 2| 3| 8| 3| 3| 3| 3| 2| 3| 3| 7| 3| 3| 3| 3| 2| 3| 7| 2| 3| 6| 3|            |
                                           | 0| 0| 2| 2| 0| 2| 0| 0| 0| 0| 7| 0| 0| 9| 0| 0| 0| 0| 5| 0| 9| 0| 0| 5| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    5.0MG/M3                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
     FEMALE                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                 +                        |   2        |
      Lens, Cataract                       |                                                 2                        |      2  2.0|
                                            __________________________________________________________________________|____________|
   Lacrimal Gland                          |                                                                          |   1        |
      Degeneration                         |                                                                          |      1  3.0|
      Inflammation, Chronic                |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Mineralization                       |                         2                                                |      3  2.7|
      Nephropathy, Chronic                 | 2  2  2  3  3  2  1  3  4  3  3  2  2  1  3  2  2  2  3  2  3  2  2  4  2|     47  2.6|
      Pelvis, Dilatation                   |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  26                                                               
NTP Experiment-Test: 05095-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          EPINEPHRINE HCL                                      Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:26:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 4| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 2| 2| 4| 6| 2| 2| 2| 5| 2| 2| 2| 2| 2| 5| 2| 2| 0| 1| 2| 2| 1| 2| 9| 1| 2|             
                                           | 9| 9| 0| 3| 9| 9| 9| 9| 9| 9| 9| 9| 9| 3| 9| 9| 7| 7| 9| 9| 7| 9| 3| 7| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    MALE                                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Parasite Metazoan                    |                               2     2                                    |             
      Artery, Inflammation, Chronic        |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    | X  2                          2                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                     2                                    |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     |                                  2           1        2     1  2         |             
      Clear Cell Focus                     | 1                 2        3  1     2  2  2           2        2     2  2|             
      Developmental Malformation           |             X                                   X              X         |             
      Eosinophilic Focus                   |                                                                          |             
      Fibrosis                             |                                                                          |             
      Inflammation, Granulomatous          |                                                    2     2  2  2         |             
      Necrosis                             |                      2                                                   |             
      Thrombosis, Multiple                 |                      2                                                   |             
      Bile Duct, Fibrosis                  |                3  2  2                                      2  2        3|             
      Bile Duct, Hyperplasia               |             2  3  2  2  1  2  2  2  2     3     2  2  2     2  2  2  2  2|             
      Hepatocyte, Vacuolization Cytoplasmic|       2                                         4                    2   |             
                                            __________________________________________________________________________|             
   Mesentery                               | +                                                                    +   |             
      Fibrosis                             |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Chronic                | 3                                                                    2   |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                 3                        |             
      Inflammation, Chronic                |                                                 3                        |             
      Acinus, Atrophy                      |    1     1                    2     2                 2  3        3      |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                | 1     1     1                                                            |             
      Karyomegaly                          |                2                                            1        1   |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                               3                                          |             
      Hyperkeratosis                       |                               2                                          |             
      Inflammation, Suppurative            |                                                 3                        |             
      Ulcer                                |                      4                                                   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  27                                                               
NTP Experiment-Test: 05095-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          EPINEPHRINE HCL                                      Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:26:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 4| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 2| 2| 4| 6| 2| 2| 2| 5| 2| 2| 2| 2| 2| 5| 2| 2| 0| 1| 2| 2| 1| 2| 9| 1| 2|             
                                           | 9| 9| 0| 3| 9| 9| 9| 9| 9| 9| 9| 9| 9| 3| 9| 9| 7| 7| 9| 9| 7| 9| 3| 7| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    MALE                                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                         3|             
      Cyst                                 |                                                    X                     |             
      Erosion                              |                      4                             2                     |             
      Fibrosis                             |                                                                         4|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Inflammation, Chronic                |                                                    3                    4|             
      Inflammation, Suppurative            |                                                 3                        |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |                2  2     2     2        1     3     2     2        2  3   |             
      Thrombosis                           |                      X                                                   |             
      Atrium, Dilatation                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                  2                                      3|             
      Mineralization                       |                               1                                          |             
      Vacuolization Cytoplasmic            | 2                                2  3           3        2  2  2        2|             
      Vacuolization Nuclear                |                                                                      2   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 2  1                       2                 2     2  1     1        2   |             
      Necrosis                             |                      3                                                   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Hyperplasia                          |                2                                                         |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Hyperplasia           |          2                 2                                             |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |                2           2        1                          2  2      |             
      Follicular Cell, Cyst                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                  X                                       |             
      Inflammation, Suppurative            |                                  4              4           4     2     3|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  28                                                               
NTP Experiment-Test: 05095-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          EPINEPHRINE HCL                                      Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:26:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 4| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 2| 2| 4| 6| 2| 2| 2| 5| 2| 2| 2| 2| 2| 5| 2| 2| 0| 1| 2| 2| 1| 2| 9| 1| 2|             
                                           | 9| 9| 0| 3| 9| 9| 9| 9| 9| 9| 9| 9| 9| 3| 9| 9| 7| 7| 9| 9| 7| 9| 3| 7| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    MALE                                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                             3            |             
      Inflammation, Suppurative            |          1                       3  2              2        3           2|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                   2                    2                    2            |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 3  3        3              3        4     3  4  3  2  3     2  4  4  4  4|             
      Mineralization                       | 3                                                                        |             
      Artery, Inflammation                 |                2                                4                        |             
      Interstitial Cell, Hyperplasia       |          1     1  1                                                      |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                 2                        |             
      Fibrosis                             |                2                                                         |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  M  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                   4      |             
      Infarct                              |                      2                                                   |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  +  M  +  +  +  +  M  +  +  M  +  M  +  +  M  M  +  +  +  +  +  +  +|             
      Galactocele                          |                                                                         X|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                                                      X   |             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                +         |             
      Diaphragm, Developmental Malformation|                                                                X         |             
      Diaphragm, Fibrosis                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                   1                             2           4           4|             
      Congestion                           |                                                                          |             
      Gliosis                              |                                                                          |             
      Hemorrhage                           |          4                                      2                        |             
      Ventricle, Dilatation                |                                        4                    4           3|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  29                                                               
NTP Experiment-Test: 05095-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          EPINEPHRINE HCL                                      Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:26:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 4| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 2| 2| 4| 6| 2| 2| 2| 5| 2| 2| 2| 2| 2| 5| 2| 2| 0| 1| 2| 2| 1| 2| 9| 1| 2|             
                                           | 9| 9| 0| 3| 9| 9| 9| 9| 9| 9| 9| 9| 9| 3| 9| 9| 7| 7| 9| 9| 7| 9| 3| 7| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    MALE                                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                           2                    2         |             
      Inflammation, Chronic                | 2                 2        2                                             |             
      Inflammation, Suppurative            |                                           3     1           2  2  2      |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |             2                                                            |             
      Hemorrhage                           |                      2           2                                       |             
      Alveolar Epithelium, Hyperplasia     |                                                                      2   |             
      Alveolus, Edema                      |                                                                          |             
      Alveolus, Fibrosis                   |                                  2                                       |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                                  2  2                                2   |             
      Alveolus, Inflammation, Suppurative  |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                               2                                         2|             
      Hemorrhage                           |                      3                                                   |             
      Inflammation, Suppurative            |                2     3        2           2                 2            |             
      Necrosis                             |                      3                                                   |             
      Glands, Dilatation                   |       1  2                    1  1  2     1                 1            |             
      Glands, Hyperplasia                  |             4                                            2               |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |                                  2              3                        |             
      Respiratory Epithelium, Hyperplasia, |                                                                          |             
           Focal                           |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |             +                                +                           |             
      Lens, Cataract                       |             2                                2                           |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |    +                                                                     |             
      Hyperplasia                          |    2                                                                     |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy, Chronic                 | 4  2  2     3  4  2  3  2  2  3  3  2  2  2  3  4  1  3  3  3  4  2  2  3|             
      Pelvis, Hyperplasia                  |                                                                          |             
      Pelvis, Inflammation, Suppurative    |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  30                                                               
NTP Experiment-Test: 05095-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          EPINEPHRINE HCL                                      Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:26:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 2| 2| 2| 2| 2| 6| 2| 2| 2| 2| 9| 2| 1| 2| 2| 0| 2| 7| 2| 2| 1| 2| 0| 1| 2|            |
                                           | 9| 9| 9| 9| 9| 1| 9| 9| 9| 9| 6| 9| 7| 9| 9| 2| 9| 9| 9| 9| 7| 9| 7| 4| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    MALE                                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hemorrhage                           |          4                                                               |      1  4.0|
      Parasite Metazoan                    |             2        2  X                                                |      5  2.0|
      Artery, Inflammation, Chronic        |                               3                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |                         X                                                |      4  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |                      2           3  2           2        3     2         |      7  2.3|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                                3        2|      2  2.5|
      Basophilic Focus                     | 2     2     2     2  2     1     2        2  2              3  2        3|     17  1.9|
      Clear Cell Focus                     |    3  2     2     2  2  2                                2               |     18  2.0|
      Developmental Malformation           |                                     X           X                        |      5     |
      Eosinophilic Focus                   |                                                                         X|      1     |
      Fibrosis                             |             2                                                            |      1  2.0|
      Inflammation, Granulomatous          |       3  1                    2              2           2     2         |     10  2.0|
      Necrosis                             |                                                                          |      1  2.0|
      Thrombosis, Multiple                 |                                                                          |      1  2.0|
      Bile Duct, Fibrosis                  |    2                                                                     |      7  2.3|
      Bile Duct, Hyperplasia               | 2  2        2     2     2  1  2  2  2     2        1  2        2     2  1|     33  1.9|
      Hepatocyte, Vacuolization Cytoplasmic|                3                                      2                  |      5  2.6|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                +              +           +                              |   5        |
      Fibrosis                             |                               4                                          |      1  4.0|
      Hemorrhage                           |                                           3                              |      1  3.0|
      Inflammation, Chronic                |                4              4                                          |      4  3.3|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis                             |                                                                          |      1  3.0|
      Inflammation, Chronic                |                                                                          |      1  3.0|
      Acinus, Atrophy                      |    4  3  2     3  3     2           2  3     2  3              2     3   |     19  2.4|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                |                                                                          |      3  1.0|
      Karyomegaly                          |                                                                          |      3  1.3|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  31                                                               
NTP Experiment-Test: 05095-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          EPINEPHRINE HCL                                      Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:26:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 2| 2| 2| 2| 2| 6| 2| 2| 2| 2| 9| 2| 1| 2| 2| 0| 2| 7| 2| 2| 1| 2| 0| 1| 2|            |
                                           | 9| 9| 9| 9| 9| 1| 9| 9| 9| 9| 6| 9| 7| 9| 9| 2| 9| 9| 9| 9| 7| 9| 7| 4| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    MALE                                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Acanthosis                           |                                                    4                     |      2  3.5|
      Hyperkeratosis                       |                                                    2                     |      2  2.0|
      Inflammation, Suppurative            |                4                             3     3              3      |      5  3.2|
      Ulcer                                |                3                                                         |      2  3.5|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                                                          |      1  3.0|
      Cyst                                 |                                                                          |      1     |
      Erosion                              |       3                                                                  |      3  3.0|
      Fibrosis                             |       3                                                                  |      2  3.5|
      Hyperplasia, Lymphoid                |                   2                                                      |      1  2.0|
      Inflammation, Chronic                |       3                                                                  |      3  3.3|
      Inflammation, Suppurative            |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                         +                                                |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       | 1  2  2     2     2  2  2  3           2  2        1  2     2  2         |     24  2.0|
      Thrombosis                           |                                                                          |      1     |
      Atrium, Dilatation                   |                                                 4                        |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                   1           2                 1  2           2        1|      8  1.8|
      Mineralization                       |                                                                          |      1  1.0|
      Vacuolization Cytoplasmic            |          2        3     2  2        1        2  2           2  2  3  2   |     19  2.2|
      Vacuolization Nuclear                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                   1  1  3                 2  2  1                        |     14  1.6|
      Necrosis                             |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                  2                       2               |      2  2.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  M  +  +  +  +  +  +  M  M  M  +  +  M  +  +  +  +  +  +  +  +  +|  43        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pars Distalis, Hyperplasia           |       1                                                                  |      3  1.7|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      C-Cell, Hyperplasia                  |          1           1                             3  2                  |      9  1.8|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  32                                                               
NTP Experiment-Test: 05095-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          EPINEPHRINE HCL                                      Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:26:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 2| 2| 2| 2| 2| 6| 2| 2| 2| 2| 9| 2| 1| 2| 2| 0| 2| 7| 2| 2| 1| 2| 0| 1| 2|            |
                                           | 9| 9| 9| 9| 9| 1| 9| 9| 9| 9| 6| 9| 7| 9| 9| 2| 9| 9| 9| 9| 7| 9| 7| 4| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    MALE                                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Follicular Cell, Cyst                |                                                          2               |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cyst                                 |                                              X           X               |      3     |
      Inflammation, Suppurative            |                                  3           3        3           4      |      9  3.3|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                                2         |      2  2.5|
      Inflammation, Suppurative            |                   2     3  3                 4     3           3         |     12  2.6|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            |                         3  3              3  4     2                     |      8  2.6|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              | 3  4  3     2  3  3  4        4  4  4  3  2  3        4  2  4  3  4  4  4|     35  3.3|
      Mineralization                       |                                                                          |      1  3.0|
      Artery, Inflammation                 |                                              3  3              2         |      5  2.8|
      Interstitial Cell, Hyperplasia       |                                                    1                     |      4  1.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                                                          |      1  2.0|
      Fibrosis                             |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|  44        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis                             |             3                 4           3                              |      3  3.3|
      Hematopoietic Cell Proliferation     |                                                                          |      1  4.0|
      Infarct                              |                               4                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +|  46        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  M  +  M  +  +  +  +  M  +  +  +  +  +  +  +  M  +  M  M  +  +  +  +  M|  35        |
      Galactocele                          |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst Epithelial Inclusion            |                                                                          |      1     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  33                                                               
NTP Experiment-Test: 05095-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          EPINEPHRINE HCL                                      Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:26:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 2| 2| 2| 2| 2| 6| 2| 2| 2| 2| 9| 2| 1| 2| 2| 0| 2| 7| 2| 2| 1| 2| 0| 1| 2|            |
                                           | 9| 9| 9| 9| 9| 1| 9| 9| 9| 9| 6| 9| 7| 9| 9| 2| 9| 9| 9| 9| 7| 9| 7| 4| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    MALE                                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Chronic                |                                                                3         |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |             +                                                            |   2        |
      Diaphragm, Developmental Malformation|                                                                          |      1     |
      Diaphragm, Fibrosis                  |             3                                                            |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression                          |          X           2        3              3     4                     |      9  2.9|
      Congestion                           |          3                                                               |      1  3.0|
      Gliosis                              |                                                    1                     |      1  1.0|
      Hemorrhage                           |                   3                                                      |      3  3.0|
      Ventricle, Dilatation                |                                                    3                     |      4  3.5|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Foreign Body                         |    2                                      2                    2         |      5  2.0|
      Inflammation, Chronic                |                                                                          |      3  2.0|
      Inflammation, Suppurative            |    1              2  2        2     2     2              3     3        2|     14  2.1|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Foreign Body                         |                                                                          |      1  2.0|
      Hemorrhage                           |                                                                          |      2  2.0|
      Alveolar Epithelium, Hyperplasia     |                                  2                                       |      2  2.0|
      Alveolus, Edema                      |                3                                                         |      1  3.0|
      Alveolus, Fibrosis                   |                                                                          |      1  2.0|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |       2                                         2                    1   |      6  1.8|
      Alveolus, Inflammation, Suppurative  |    1                                                                     |      1  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Foreign Body                         | 2  2                                                                     |      4  2.0|
      Hemorrhage                           |                                                                          |      1  3.0|
      Inflammation, Suppurative            | 1  3                                            3                        |      8  2.3|
      Necrosis                             |                                                                          |      1  3.0|
      Glands, Dilatation                   |                         1  2              1  1     2        2            |     13  1.4|
      Glands, Hyperplasia                  |                                                                          |      2  3.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |                                                                          |      2  2.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  34                                                               
NTP Experiment-Test: 05095-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          EPINEPHRINE HCL                                      Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:26:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 2| 2| 2| 2| 2| 6| 2| 2| 2| 2| 9| 2| 1| 2| 2| 0| 2| 7| 2| 2| 1| 2| 0| 1| 2|            |
                                           | 9| 9| 9| 9| 9| 1| 9| 9| 9| 9| 6| 9| 7| 9| 9| 2| 9| 9| 9| 9| 7| 9| 7| 4| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    MALE                                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Respiratory Epithelium, Hyperplasia, |                                                                          |            |
           Focal                           |                                                 2                        |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            |                                  2                                       |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                       +           +      |   4        |
      Lens, Cataract                       |                                                       2           3      |      4  2.3|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
      Hyperplasia                          |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Nephropathy, Chronic                 | 3  2  3  3  3  2  3  3  3  3  2  3  2  2  3  4  4  2  2  3  3  3  3  4  3|     49  2.8|
      Pelvis, Hyperplasia                  |                                              2                           |      1  2.0|
      Pelvis, Inflammation, Suppurative    |                         2                    4                           |      2  3.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                              2                           |      1  2.0|
      Inflammation, Suppurative            |                         3                    3                           |      2  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  35                                                               
NTP Experiment-Test: 05095-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          EPINEPHRINE HCL                                      Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:26:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 6| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 6| 7| 7| 6| 7|             
                             DAY ON TEST   | 3| 7| 5| 7| 1| 7| 3| 3| 3| 5| 3| 3| 0| 3| 8| 3| 3| 3| 6| 3| 9| 3| 3| 8| 3|             
                                           | 1| 2| 1| 7| 0| 2| 1| 1| 1| 9| 1| 1| 2| 1| 1| 1| 1| 1| 8| 1| 3| 1| 1| 6| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    1.5MG/M3                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
     MALE                                  | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +  +  +  +  +           +        +     +           +     +        +   |             
                                            __________________________________________________________________________|             
   Intestine Large                         |    +  +  +  A  +  +        +        +     +     +     A     +     +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    +  +  +  A  +  +        +        +     +     +     A     +     +  +   |             
      Hemorrhage                           |                   1                             2                 4      |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +  +  +  A  +           +        +     +           A     +        +   |             
      Parasite Metazoan                    |    2                                2                                    |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +  +  +  A  +           +        +     +           A     +        +   |             
                                            __________________________________________________________________________|             
   Intestine Small                         |    +  +  +  A  +           +        +     +           A     +        +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +  +  +  A  +           +        +     +           A     +        +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    +  +  +  A  +           +        +     +           A     +        +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +  +  +  A  +           +        +     +           A     +        +   |             
                                            __________________________________________________________________________|             
   Liver                                   |    +  +  +  +  +           +     +  +     +  +     +  +  +  +     +  +   |             
      Basophilic Focus                     |    3                                                        2            |             
      Clear Cell Focus                     |                                                    2                     |             
      Developmental Malformation           |                                           X  X                           |             
      Inflammation, Granulomatous          |                                     2                                2   |             
      Necrosis                             |          3                       4                                       |             
      Bile Duct, Hyperplasia               |       2        3           3     2                 2     2           2   |             
      Hepatocyte, Vacuolization Cytoplasmic|          3     4                                                     3   |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                              +                           |             
      Inflammation, Chronic                |                                                                          |             
      Necrosis                             |                                              4                           |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +  +  +  +  +           +        +     +           +     +        +   |             
      Acinus, Atrophy                      |    2  2  2                 3        2     3                              |             
      Artery, Inflammation                 |                                     3                                    |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +  +  +  +  +           +        +     +           +     +        +   |             
      Hemorrhage                           |                            4                                             |             
                                            __________________________________________________________________________|             
   Stomach                                 |    +  +  +  +  +           +        +     +     +     +  +  +     +  +   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +  +  +  +  +           +        +     +     +     +  +  +     +  +   |             
      Acanthosis                           |          2     3                                                         |             
      Diverticulum                         |                                                                   2      |             
      Fibrosis                             |                                                          3               |             
      Inflammation, Suppurative            |          4                                                               |             
      Ulcer                                |                4                                                         |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +  +  +  +  +           +        +     +     +     +     +        +   |             
      Inflammation, Suppurative            |                                                                          |             
      Epithelium, Hyperplasia              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |    +  +  +  +  +           +        +     +           +     +        +   |             
      Cardiomyopathy                       |    2     2  2                                                            |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |    +  +  +  +  +           +     +  +     +           +     +        +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  36                                                               
NTP Experiment-Test: 05095-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          EPINEPHRINE HCL                                      Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:26:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 6| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 6| 7| 7| 6| 7|             
                             DAY ON TEST   | 3| 7| 5| 7| 1| 7| 3| 3| 3| 5| 3| 3| 0| 3| 8| 3| 3| 3| 6| 3| 9| 3| 3| 8| 3|             
                                           | 1| 2| 1| 7| 0| 2| 1| 1| 1| 9| 1| 1| 2| 1| 1| 1| 1| 1| 8| 1| 3| 1| 1| 6| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    1.5MG/M3                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
     MALE                                  | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |    +  +  +  +  +           +        +     +           +     +        +   |             
      Vacuolization Cytoplasmic            |    2  2        2                                                     1   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |    +  +  +  +  +           +     +  +     +           +     +        +   |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +  +  +  +  +           +        +     +           +     +        +   |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    +  +  +  +  +           +        M     M           +     +        +   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +     +     +  +  +  +           +     +     +  +   |             
      Cyst                                 |                            X                                             |             
      Pars Distalis, Hyperplasia           |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |    +  +  +  +  +           +        +     +     +     +     +        +   |             
      C-Cell, Hyperplasia                  |          4                                                               |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |    +  +  +  +  +           +        +  +  +     +     +     +        +   |             
      Angiectasis                          |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |    +  +  +  +  +           +        +     +           +  +  +        +   |             
      Cyst                                 |                                                          X               |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                |    +  +  +  M  +           +        +     +           +     +        +   |             
      Inflammation, Suppurative            |                                                       2              3   |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |    +  +  +  +  +           +        +     +           +     +        +   |             
      Inflammation, Suppurative            |                            4                                             |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Atrophy                              |                3        4        3           4              4        4  4|             
      Artery, Inflammation                 |    3                                4                                    |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +  +  +  +  +           +        +     +           +     +        +   |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +  +  +  +  +           +        +     +           +     +     +  +   |             
      Renal, Hyperplasia                   |    2                                                                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   |    +  +  +  M  +           +        +     +           +     +        +   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |    +  +  +  +  +           +        +     +           +     +     +  +   |             
                                            __________________________________________________________________________|             
   Spleen                                  |    +  +  +  +  +           +     +  +     +           +  +  +     +  +   |             
      Fibrosis                             |                                                          3               |             
                                            __________________________________________________________________________|             
   Thymus                                  |    +  +  +  +  +           +        +     +           +     +        +   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    +  +  +  +  +           +        +     +           +     M        M   |             
                                            __________________________________________________________________________|             
   Skin                                    |    +  +  +  +  +           +  +     +     +           +     +        +   |             
      Cyst Epithelial Inclusion            |                               X                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  37                                                               
NTP Experiment-Test: 05095-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          EPINEPHRINE HCL                                      Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:26:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 6| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 6| 7| 7| 6| 7|             
                             DAY ON TEST   | 3| 7| 5| 7| 1| 7| 3| 3| 3| 5| 3| 3| 0| 3| 8| 3| 3| 3| 6| 3| 9| 3| 3| 8| 3|             
                                           | 1| 2| 1| 7| 0| 2| 1| 1| 1| 9| 1| 1| 2| 1| 1| 1| 1| 1| 8| 1| 3| 1| 1| 6| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    1.5MG/M3                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
     MALE                                  | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +  +  +  +  +           +        +     +           +     +        +   |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +  +  +  +  +           +        +     +           +     +        +   |             
      Compression                          |    3     3                          4     3           3                  |             
      Hemorrhage                           |          3                 3                          2                  |             
      Ventricle, Dilatation                |                                                             4            |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |       +                                                                  |             
      Hemorrhage                           |       4                                                                  |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  |    +  +  +  +  +           +        +     +           +     +        +   |             
      Hemorrhage                           |    2                                                                     |             
      Inflammation, Suppurative            |                            2                          2              2   |             
      Epithelium, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +        +        +     +  +     +  +     +        +   |             
      Hemorrhage                           |                                                       2                  |             
      Alveolar Epithelium, Hyperplasia     |                   3                          2     3                     |             
      Alveolus, Edema                      |             3                                                            |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                                              3                           |             
      Alveolus, Inflammation, Suppurative  |    2                                                                     |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                   2                                            2         |             
      Inflammation, Suppurative            |                   2                                            3         |             
      Glands, Dilatation                   |    2  2        1     1  2  2                                2        2   |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |                                                                          |             
      Respiratory Epithelium, Hyperplasia  |                                                          2     2         |             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |                                                                         1|             
                                            __________________________________________________________________________|             
   Trachea                                 |    +  +  +  +  +           +        +     +           +     +        +   |             
      Inflammation, Chronic                |                                                             3            |             
      Epithelium, Hyperplasia              |                                                             2            |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     | +                                                                        |             
                                            __________________________________________________________________________|             
   Eye                                     |                      +           +                 +                     |             
      Cataract                             |                                  2                                       |             
      Lens, Cataract                       |                      2                                                   |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  38                                                               
NTP Experiment-Test: 05095-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          EPINEPHRINE HCL                                      Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:26:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 6| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 6| 7| 7| 6| 7|             
                             DAY ON TEST   | 3| 7| 5| 7| 1| 7| 3| 3| 3| 5| 3| 3| 0| 3| 8| 3| 3| 3| 6| 3| 9| 3| 3| 8| 3|             
                                           | 1| 2| 1| 7| 0| 2| 1| 1| 1| 9| 1| 1| 2| 1| 1| 1| 1| 1| 8| 1| 3| 1| 1| 6| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    1.5MG/M3                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
     MALE                                  | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |    +  +  +  +  +  +        +        +     +           +     +        +   |             
      Infarct                              |                            4                                             |             
      Nephropathy, Chronic                 |    4  2  3  3  1  4        2        4     3           3     2        3   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    +  +  +  +  +           +        +     +           A     +        +   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  39                                                               
NTP Experiment-Test: 05095-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          EPINEPHRINE HCL                                      Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:26:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 6| 6| 7| 7| 6| 7| 6| 5| 7| 7| 5| 7| 6| 7| 7| 6| 7| 6| 7| 6|            |
                             DAY ON TEST   | 3| 3| 3| 1| 3| 0| 4| 3| 3| 9| 3| 9| 9| 3| 3| 3| 3| 0| 2| 3| 2| 3| 9| 3| 3|            |
                                           | 1| 1| 1| 7| 1| 9| 4| 1| 1| 9| 1| 3| 8| 1| 1| 5| 1| 1| 0| 0| 3| 1| 9| 0| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    1.5MG/M3                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
     MALE                                  | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |          +     +  +        +     +  +        +     +  +  +  +     +     +|  24        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |          +     A  +        +     +  +        +     A  +  +  +     +     +|  23        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |          +     M  +        A     +  +        +     A  +  +  +     +     +|  22        |
      Hemorrhage                           |                                                                          |      3  2.3|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |          +     A  +        +     +  +        +     A  +  +  +     +     +|  20        |
      Parasite Metazoan                    |                            2                 2                           |      4  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |          +     A  +        +     +  +        +     A  +  +  +     +     +|  20        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |          +     A  +        +     +  +        +     +  +  +  +     +     +|  21        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |          +     A  +        +     +  +        +     +  +  +  +     +     +|  21        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |          +     A  +        A     +  +        +     A  +  +  +     +     +|  19        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |          +     A  +        +     +  +        +     A  +  +  +     +     +|  20        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +     +  +  +  A  +     +  +     +  +        +     +  +  +  +     +  +  +|  33        |
      Basophilic Focus                     |                                  2           3     2                     |      5  2.4|
      Clear Cell Focus                     |                                                                          |      1  2.0|
      Developmental Malformation           | X                                                  X                     |      4     |
      Inflammation, Granulomatous          |                                                          2               |      3  2.0|
      Necrosis                             |                   2        2                             3               |      5  2.8|
      Bile Duct, Hyperplasia               |          2        2        2     2           2     2                    3|     14  2.2|
      Hepatocyte, Vacuolization Cytoplasmic|          2                                                        4      |      5  3.2|
                                            __________________________________________________________________________|____________|
   Mesentery                               |    +                             +           +     +                     |   5        |
      Inflammation, Chronic                |                                  3                 3                     |      2  3.0|
      Necrosis                             |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                |          +     A  +        +     +  +        +     +  +  +  +     +     +|  23        |
      Acinus, Atrophy                      |          3                       2  2                 2  2               |     11  2.3|
      Artery, Inflammation                 |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |          +     +  +        +     +  +        +     +  +  +  +     +     +|  24        |
      Hemorrhage                           |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 |          +     A  +        +     +  +  +     +     +  +  +  +     +     +|  27        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |          +     A  +        +     +  +        +     +  +  +  +     +     +|  26        |
      Acanthosis                           |                                                                   3      |      3  2.7|
      Diverticulum                         |                                                                          |      1  2.0|
      Fibrosis                             |                                                                          |      1  3.0|
      Inflammation, Suppurative            |                                                                   3      |      2  3.5|
      Ulcer                                |                                                                   2      |      2  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |          +     A  +        +     +  +  +     +     +  +  +  +     +     +|  25        |
      Inflammation, Suppurative            |                                                    3              3      |      2  3.0|
      Epithelium, Hyperplasia              |                                        3                                 |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  40                                                               
NTP Experiment-Test: 05095-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          EPINEPHRINE HCL                                      Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:26:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 6| 6| 7| 7| 6| 7| 6| 5| 7| 7| 5| 7| 6| 7| 7| 6| 7| 6| 7| 6|            |
                             DAY ON TEST   | 3| 3| 3| 1| 3| 0| 4| 3| 3| 9| 3| 9| 9| 3| 3| 3| 3| 0| 2| 3| 2| 3| 9| 3| 3|            |
                                           | 1| 1| 1| 7| 1| 9| 4| 1| 1| 9| 1| 3| 8| 1| 1| 5| 1| 1| 0| 0| 3| 1| 9| 0| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    1.5MG/M3                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
     MALE                                  | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |          +     +  +        +     +  +        +     +  +  +  +     +     +|  24        |
      Cardiomyopathy                       |                            2                       2  1  2               |      7  1.9|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |          +  +  A  +        +     +  +        +     +  +  +  +     +     +|  26        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |          +     A  +        +     +  +        +     +  +  +  +     +     +|  23        |
      Vacuolization Cytoplasmic            |          3                 3                          2           3      |      8  2.3|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |          +  +  A  +        +     +  +        +     +  +  +  +     +     +|  25        |
      Hyperplasia                          |                   2                 1                                    |      2  1.5|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |          +     +  +        +     +  +        +     +  +  +  +     +     +|  24        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |          +     +  M        +     +  M        +     M  +  +  +     +     +|  19        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |       +  +  +  +  +  +     +     +  +  +  +  +     +  +  +  M  +  +  +  +|  36        |
      Cyst                                 |                X                                                         |      2     |
      Pars Distalis, Hyperplasia           |                   3                                                      |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |          +     A  +        +     +  +        +     +  +  +  +     +     +|  24        |
      C-Cell, Hyperplasia                  |                                  3                       4               |      3  3.7|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              |          +     +  +        +     +  +        +     +  +  +  +     +  +  +|  27        |
      Angiectasis                          |                                                                      4   |      1  4.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |          +  +  M  +        +     +  +        +     +  +  +  +     +     +|  25        |
      Cyst                                 |             X                                                            |      2     |
      Inflammation, Suppurative            |                                                          4               |      1  4.0|
                                            __________________________________________________________________________|____________|
   Prostate                                |          +  +  +  +        +     +  +        +     +  +  +  +     +  +  +|  25        |
      Inflammation, Suppurative            |             4                                3     2                 3   |      6  2.8|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |          +     +  +        +     +  +        +     +  +  +  +     +     +|  24        |
      Inflammation, Suppurative            |                            3     2                                       |      3  3.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Atrophy                              | 4  2  4  3        4  3  3     3        4  4     3        4  3  4  4  3   |     23  3.5|
      Artery, Inflammation                 |                                                                          |      2  3.5|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |          +     A  +        +     +  +        +     +  +  +  +     +     +|  23        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |       +  +  +  +  +        +     +  +        +  +  +  +  +  +     +     +|  28        |
      Renal, Hyperplasia                   |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   |          +     M  +        +     +  +        +     +  +  +  +     +     +|  22        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  41                                                               
NTP Experiment-Test: 05095-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          EPINEPHRINE HCL                                      Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:26:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 6| 6| 7| 7| 6| 7| 6| 5| 7| 7| 5| 7| 6| 7| 7| 6| 7| 6| 7| 6|            |
                             DAY ON TEST   | 3| 3| 3| 1| 3| 0| 4| 3| 3| 9| 3| 9| 9| 3| 3| 3| 3| 0| 2| 3| 2| 3| 9| 3| 3|            |
                                           | 1| 1| 1| 7| 1| 9| 4| 1| 1| 9| 1| 3| 8| 1| 1| 5| 1| 1| 0| 0| 3| 1| 9| 0| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    1.5MG/M3                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
     MALE                                  | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |          +     +  +        +     +  +        +     +  +  +  +     M     +|  24        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +     +  +  +  A  +     +  +     +  +        +  +  +  +  +  +     +  +  +|  32        |
      Fibrosis                             | 3           3                                                            |      3  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  |          +     M  +        +     +  +        M     +  +  +  +     +     +|  22        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |          +     +  +        +     M  +        +     +  M  +  +     +     +|  20        |
                                            __________________________________________________________________________|____________|
   Skin                                    |          +     +  +        +     +  +     +  +     +  +  +  +     +     +|  26        |
      Cyst Epithelial Inclusion            |                                           X              X               |      3     |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |          +     +  +        +     +  +        +     +  +  +  +     +     +|  24        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                             +            |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |          +     +  +        +     +  +        +     +  +  +  +     +     +|  24        |
      Compression                          |                            3     3  3              2  2           2      |     11  2.8|
      Hemorrhage                           |                            2        3                                   3|      6  2.7|
      Ventricle, Dilatation                |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
      Hemorrhage                           |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  |          +     +  +        +     +  +        +     +  +  +  +     +     +|  24        |
      Hemorrhage                           |                                                                          |      1  2.0|
      Inflammation, Suppurative            |                                     2              2        3            |      6  2.2|
      Epithelium, Hyperplasia              |                                                             2            |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lung                                    |          +     A  +        +     +  +  +     +     +  +  +  +  +  +     +|  29        |
      Hemorrhage                           |                                                    2                     |      2  2.0|
      Alveolar Epithelium, Hyperplasia     |                                        4                                 |      4  3.0|
      Alveolus, Edema                      |                                                                          |      1  3.0|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |                                              2                    2     4|      4  2.8|
      Alveolus, Inflammation, Suppurative  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Foreign Body                         |                               2     2              2                     |      5  2.0|
      Inflammation, Suppurative            | 3           2              2  3     4              3     3               |      9  2.8|
      Glands, Dilatation                   | 1     2     1                       2        2  2  2  2     2  1     1   |     19  1.7|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  42                                                               
NTP Experiment-Test: 05095-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          EPINEPHRINE HCL                                      Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:26:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 6| 6| 7| 7| 6| 7| 6| 5| 7| 7| 5| 7| 6| 7| 7| 6| 7| 6| 7| 6|            |
                             DAY ON TEST   | 3| 3| 3| 1| 3| 0| 4| 3| 3| 9| 3| 9| 9| 3| 3| 3| 3| 0| 2| 3| 2| 3| 9| 3| 3|            |
                                           | 1| 1| 1| 7| 1| 9| 4| 1| 1| 9| 1| 3| 8| 1| 1| 5| 1| 1| 0| 0| 3| 1| 9| 0| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    1.5MG/M3                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
     MALE                                  | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
           Suppurative                     |                   3                                                      |      1  3.0|
      Respiratory Epithelium, Hyperplasia  | 1                          2        3                                    |      5  2.0|
      Respiratory Epithelium, Metaplasia,  |                                                                          |            |
           Squamous                        | 2                          1                                             |      3  1.3|
                                            __________________________________________________________________________|____________|
   Trachea                                 |          +     +  +        +     +  +        +     +  +  +  +     +     +|  24        |
      Inflammation, Chronic                |                                                                          |      1  3.0|
      Epithelium, Hyperplasia              |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   3        |
      Cataract                             |                                                                          |      1  2.0|
      Lens, Cataract                       |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |          +  +  A  +        +     +  +        +     +  +  +  +     +  +  +|  26        |
      Infarct                              |                                                                          |      1  4.0|
      Nephropathy, Chronic                 |          2  4     3        4     2  2        2     2  4  3  3     4  4  2|     26  2.9|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |          +     A  +        +     +  +        +     +  +  +  +     +     +|  22        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  43                                                               
NTP Experiment-Test: 05095-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          EPINEPHRINE HCL                                      Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:26:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 7| 7| 7| 7| 5| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5|             
                             DAY ON TEST   | 3| 3| 6| 3| 3| 3| 3| 5| 3| 3| 6| 3| 0| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0|             
                                           | 0| 0| 0| 0| 0| 0| 0| 6| 0| 0| 6| 0| 3| 0| 4| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    5.0MG/M3                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
     MALE                                  | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Parasite Metazoan                    |                                                             2            |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  I  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Parasite Metazoan                    |                                        2              2                  |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Angiectasis, Focal                   |                                                                3         |             
      Basophilic Focus                     | 2                 1        3     2     2     3  3  2        1        1   |             
      Clear Cell Focus                     |                                     2                             2  2   |             
      Developmental Malformation           |                      X                                                   |             
      Inflammation, Granulomatous          |          2                                            2              2   |             
      Inflammation, Suppurative            |                                                                          |             
      Necrosis                             |             3                             3                              |             
      Bile Duct, Fibrosis                  |                                           2                       1      |             
      Bile Duct, Hyperplasia               |    2  2  2  3  2  1     3  3  1     3     3  3     2     1     3  1  2   |             
      Hepatocyte, Vacuolization Cytoplasmic|                                              3  3  2     2     3         |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Fat, Necrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Inflammation, Chronic                |                                        2                                 |             
      Acinus, Atrophy                      |       2                 3        1                       2  1  2  2      |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Inflammation, Chronic                |    2                                               2                     |             
      Karyomegaly                          |                         1        1        1        2                     |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Acanthosis                           |                                                                          |             
      Hyperkeratosis                       |                                                                          |             
      Inflammation, Suppurative            |             3                                                            |             
      Ulcer                                |                                                                          |             
      Muscularis, Hyperplasia              |       2                                                                  |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  A|             
      Fibrosis                             |                                                             3  3         |             
      Inflammation, Chronic                |                                                             3  3         |             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  44                                                               
NTP Experiment-Test: 05095-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          EPINEPHRINE HCL                                      Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:26:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 7| 7| 7| 7| 5| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5|             
                             DAY ON TEST   | 3| 3| 6| 3| 3| 3| 3| 5| 3| 3| 6| 3| 0| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0|             
                                           | 0| 0| 0| 0| 0| 0| 0| 6| 0| 0| 6| 0| 3| 0| 4| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    5.0MG/M3                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
     MALE                                  | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |    2     1     2  3     2  2  2  2        2  3     2           2        2|             
      Thrombosis                           |                         X                                                |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Developmental Malformation           |                                                       X                  |             
      Hemorrhage                           |                                           3                              |             
      Hyperplasia                          |                                     1           2  2                     |             
      Vacuolization Cytoplasmic            | 3                       3                 2                       2  1   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Hyperplasia, Focal                   |                                     2                                    |             
      Hyperplasia                          | 3  2                                            2  2  2  2  2     3  3   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  M  +  +  +  M  +  +  M  +  +  M  M  M  +  +  M  +  +  M|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Pars Distalis, Angiectasis           |                                                                          |             
      Pars Distalis, Hyperplasia           |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      C-Cell, Hyperplasia                  |          2                                                               |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  M  +  A|             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Cyst                                 |                                                                          |             
      Inflammation, Suppurative            |                                              4        4                  |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Inflammation, Suppurative            |                      2  2                             2     3            |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Inflammation, Suppurative            |                2                 2                                   2   |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |    4     3  4  3  4  4  2  4  2  3  3     3  3  3  4  3  3  3  4     4   |             
      Mineralization                       |                                              4                           |             
      Artery, Inflammation                 | 2                                            3                           |             
      Interstitial Cell, Hyperplasia       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  45                                                               
NTP Experiment-Test: 05095-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          EPINEPHRINE HCL                                      Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:26:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 7| 7| 7| 7| 5| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5|             
                             DAY ON TEST   | 3| 3| 6| 3| 3| 3| 3| 5| 3| 3| 6| 3| 0| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0|             
                                           | 0| 0| 0| 0| 0| 0| 0| 6| 0| 0| 6| 0| 3| 0| 4| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    5.0MG/M3                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
     MALE                                  | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  +  +  +  +  +  +  +  M  +  M  +  +  M  +  +  +  +  M  +  M  +  +  +  A|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Developmental Malformation           |                X                                                         |             
      Fibrosis                             |                            3                                             |             
      Hematopoietic Cell Proliferation     |                   3                                                      |             
      Hemorrhage                           |             4                                                            |             
      Infarct                              |                         2           2     2                              |             
      Pigmentation, Hemosiderin            |                               4                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  M|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                3                                                         |             
      Cyst Epithelial Inclusion            |                X  X                                                      |             
      Hyperkeratosis                       |                3                                                         |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                      +                                                   |             
      Diaphragm, Developmental Malformation|                      X                                                   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |       3                                      3                           |             
      Hemorrhage                           |                               2     4     3                              |             
      Mineralization                       |                                                                          |             
      Necrosis                             |                                           3                              |             
      Thrombosis                           |                                           2                              |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  A|             
      Foreign Body                         |                                  2        2                              |             
      Inflammation, Suppurative            |                   2        2  2  3        2              1     2  2      |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Hemorrhage                           |                               3  1                                       |             
      Alveolar Epithelium, Hyperplasia     |                2                                                         |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                                           2                       4      |             
      Alveolus, Inflammation, Suppurative  |                   2                             2              1         |             
      Artery, Mediastinum, Inflammation    |                                  2                                       |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  46                                                               
NTP Experiment-Test: 05095-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          EPINEPHRINE HCL                                      Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:26:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 7| 7| 7| 7| 5| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5|             
                             DAY ON TEST   | 3| 3| 6| 3| 3| 3| 3| 5| 3| 3| 6| 3| 0| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0|             
                                           | 0| 0| 0| 0| 0| 0| 0| 6| 0| 0| 6| 0| 3| 0| 4| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    5.0MG/M3                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
     MALE                                  | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                        2     1     2                    2|             
      Inflammation, Suppurative            |    1     2        1        2           2        3  2                     |             
      Glands, Dilatation                   |    2  2  3  2  2  2  1  3  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2   |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |                                           2                              |             
      Olfactory Epithelium, Metaplasia     |                                                 2                        |             
      Respiratory Epithelium, Hyperplasia  |          2  2                    1  1     2  2  2  2  2                  |             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                               +                                          |             
                                            __________________________________________________________________________|             
   Eye                                     | +                                                              +         |             
      Lens, Cataract                       | 2                                                              2         |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Nephropathy, Chronic                 | 3  3  2  3  3  2  3  2  3  2  3  3  3  3  3  4  3  3  2  3  2  4  3  3   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  47                                                               
NTP Experiment-Test: 05095-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          EPINEPHRINE HCL                                      Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:26:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 6| 6| 6| 7| 7| 6|            |
                             DAY ON TEST   | 1| 3| 3| 3| 3| 7| 3| 3| 3| 3| 1| 3| 1| 3| 3| 4| 0| 3| 7| 9| 3| 5| 3| 3| 3|            |
                                           | 1| 0| 0| 0| 0| 4| 0| 0| 0| 0| 7| 0| 8| 0| 0| 4| 7| 0| 2| 5| 7| 0| 0| 0| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    5.0MG/M3                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
     MALE                                  | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|  46        |
      Parasite Metazoan                    |       3                                                                  |      2  2.5|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | A  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|  45        |
      Parasite Metazoan                    |                                  2           2                           |      4  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  +|  44        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Angiectasis, Focal                   |                                                                          |      1  3.0|
      Basophilic Focus                     |    2  2              1  2  2  1     1  2  2        2  2              1   |     22  1.8|
      Clear Cell Focus                     |    2  2  2           1                                                   |      7  1.9|
      Developmental Malformation           |          X                                                               |      2     |
      Inflammation, Granulomatous          |       2                    1        2  2  3                          3   |      9  2.1|
      Inflammation, Suppurative            |                                                                         3|      1  3.0|
      Necrosis                             |                                                                          |      2  3.0|
      Bile Duct, Fibrosis                  |                                                                          |      2  1.5|
      Bile Duct, Hyperplasia               |    2  2  2  2  2  1              2     2        2                       2|     27  2.1|
      Hepatocyte, Vacuolization Cytoplasmic|                                                             2  3         |      7  2.6|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                   +                                                  +   |   2        |
      Inflammation, Chronic                |                   4                                                  3   |      2  3.5|
      Fat, Necrosis                        |                                                                      3   |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Acinus, Atrophy                      |                   2     2     2  2     3        2     2     2     3  3  3|     18  2.2|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Chronic                |                      1                                                   |      3  1.7|
      Karyomegaly                          |                                                                          |      4  1.3|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Acanthosis                           |                         3                                   3  2         |      3  2.7|
      Hyperkeratosis                       | 2                                                           3  2         |      3  2.3|
      Inflammation, Suppurative            |                         4                                   4  3         |      4  3.5|
      Ulcer                                |                         4                                                |      1  4.0|
      Muscularis, Hyperplasia              |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  48                                                               
NTP Experiment-Test: 05095-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          EPINEPHRINE HCL                                      Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:26:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 6| 6| 6| 7| 7| 6|            |
                             DAY ON TEST   | 1| 3| 3| 3| 3| 7| 3| 3| 3| 3| 1| 3| 1| 3| 3| 4| 0| 3| 7| 9| 3| 5| 3| 3| 3|            |
                                           | 1| 0| 0| 0| 0| 4| 0| 0| 0| 0| 7| 0| 8| 0| 0| 4| 7| 0| 2| 5| 7| 0| 0| 0| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    5.0MG/M3                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
     MALE                                  | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Fibrosis                             |                                                                          |      2  3.0|
      Inflammation, Chronic                |                                                                          |      2  3.0|
      Inflammation, Suppurative            |                                  3                             2         |      2  2.5|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       | 2     2  2  2     3     2  4  2  1     2  2     2  2     2           2   |     28  2.1|
      Thrombosis                           |                                                                         X|      2     |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Developmental Malformation           |                                                                          |      1     |
      Hemorrhage                           |                                                                          |      1  3.0|
      Hyperplasia                          |                   2                             3                        |      5  2.0|
      Vacuolization Cytoplasmic            |       2        2  1     2  1                    2           4  3         |     13  2.2|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hyperplasia, Focal                   |                                                                          |      1  2.0|
      Hyperplasia                          |          2     2                                                  2      |     12  2.3|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  M  +  M  +  +  M  +  +|  37        |
      Hyperplasia                          |                                              2                           |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Pars Distalis, Angiectasis           |                                                                      2   |      1  2.0|
      Pars Distalis, Hyperplasia           |                            1                                             |      1  1.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      C-Cell, Hyperplasia                  |    3                    2                       2  2  2                  |      6  2.2|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | M  +  M  +  +  M  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +|  39        |
      Inflammation, Chronic                |                   4                                                      |      1  4.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cyst                                 | X           X     X                                               X      |      4     |
      Inflammation, Suppurative            |          4           4     4           4           2  4           3     4|     10  3.7|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Suppurative            |                   3     4              3                             1   |      8  2.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  49                                                               
NTP Experiment-Test: 05095-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          EPINEPHRINE HCL                                      Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:26:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 6| 6| 6| 7| 7| 6|            |
                             DAY ON TEST   | 1| 3| 3| 3| 3| 7| 3| 3| 3| 3| 1| 3| 1| 3| 3| 4| 0| 3| 7| 9| 3| 5| 3| 3| 3|            |
                                           | 1| 0| 0| 0| 0| 4| 0| 0| 0| 0| 7| 0| 8| 0| 0| 4| 7| 0| 2| 5| 7| 0| 0| 0| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    5.0MG/M3                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
     MALE                                  | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Suppurative            |                   3     4              3                    3            |      7  2.7|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              | 3  4  3  3  4  2  3  3  2  4  4  3  4  3  4  4  4  3     3        4  3   |     41  3.3|
      Mineralization                       |                                                                          |      1  4.0|
      Artery, Inflammation                 |                         4                                                |      3  3.0|
      Interstitial Cell, Hyperplasia       |                                  1                                       |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  42        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Developmental Malformation           |                                                                          |      1     |
      Fibrosis                             |                                                                   4      |      2  3.5|
      Hematopoietic Cell Proliferation     |                                                                          |      1  3.0|
      Hemorrhage                           |                                                                          |      1  4.0|
      Infarct                              |                                                                          |      3  2.0|
      Pigmentation, Hemosiderin            |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  M  M  M  +  +|  41        |
      Hyperplasia                          |                                                 2                        |      1  2.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acanthosis                           |                                                                          |      1  3.0|
      Cyst Epithelial Inclusion            |                                                                          |      2     |
      Hyperkeratosis                       |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
      Diaphragm, Developmental Malformation|                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression                          |                                              3                           |      3  3.0|
      Hemorrhage                           | 3                 1                                      4               |      6  2.8|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  50                                                               
NTP Experiment-Test: 05095-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          EPINEPHRINE HCL                                      Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:26:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 6| 6| 6| 7| 7| 6|            |
                             DAY ON TEST   | 1| 3| 3| 3| 3| 7| 3| 3| 3| 3| 1| 3| 1| 3| 3| 4| 0| 3| 7| 9| 3| 5| 3| 3| 3|            |
                                           | 1| 0| 0| 0| 0| 4| 0| 0| 0| 0| 7| 0| 8| 0| 0| 4| 7| 0| 2| 5| 7| 0| 0| 0| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    5.0MG/M3                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
     MALE                                  | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Mineralization                       |                                           4                              |      1  4.0|
      Necrosis                             |                                                                          |      1  3.0|
      Thrombosis                           |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Foreign Body                         |                                                             2            |      3  2.0|
      Inflammation, Suppurative            |    3                                2           2        2        2      |     13  2.1|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hemorrhage                           |                                                                   2      |      3  2.0|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      1  2.0|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |                                                                          |      2  3.0|
      Alveolus, Inflammation, Suppurative  |                                                    2                    2|      5  1.8|
      Artery, Mediastinum, Inflammation    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Foreign Body                         |    2                          2     2              2     2  2            |     10  1.9|
      Inflammation, Suppurative            |    3     2                    2     4              4     3  3  2     2  2|     17  2.4|
      Glands, Dilatation                   |    1  2  2  2     2  2  2  2  3     2  2  2  2  2  2  3  2  2  2     2  2|     44  2.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |                                                                          |      1  2.0|
      Olfactory Epithelium, Metaplasia     |                                                                          |      1  2.0|
      Respiratory Epithelium, Hyperplasia  |             4                 2     3              2        2           3|     15  2.1|
      Respiratory Epithelium, Metaplasia,  |                                                                          |            |
           Squamous                        |          2                                                               |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Eye                                     |                      +                                                   |   3        |
      Lens, Cataract                       |                      3                                                   |      3  2.3|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Nephropathy, Chronic                 | 3  3  3  2  3  2  3  3  4  3  2  3  2  2  4  2  2  3  3  3  2  3  3  3  3|     49  2.8|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
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