National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/1166

TR 380 Rat Pathology Tables

NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11 
LAB: Battelle Northwest                                        DATE: 09/12/94   
EXP: 05095                     EPINEPHRINE HCL                 TIME: 23:41:20   
TEST: 01              CAGES FROM 0000 TO LAST CAGE             PAGE:   1        
TEST TYPE: CHRONIC          ROUTE: RESPIRATORY EXPOSURE WHOLE  NTP C#: 55663    
CONT: N01-ES-38061                                             CAS: 55-31-2     
PATHOLOGIST: R. RENNE                                                           
--------------------------------------------------------------------------------
                                                                                
                                                                                
                                                                                


REASONS FOR REMOVAL:                                                            
                                                                                
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REMOVAL DATE RANGE:                                                             


ALL                                                                             
                                                                                
TREATMENT GROUPS:                                                               
                                                                                
INCLUDE ALL                                                                     

NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11
LAB: Battelle Northwest                                        DATE: 09/12/94  
EXP: 05095                     EPINEPHRINE HCL                 TIME: 23:41:20  
TEST: 01              CAGES FROM 0000 TO LAST CAGE                             
TEST TYPE: CHRONIC          ROUTE: RESPIRATORY EXPOSURE WHOLE  NTP C#: 55663   
CONT: N01-ES-38061                                             CAS: 55-31-2    
PATHOLOGIST: R. RENNE                                                          

                                  EPINEPHRINE HCL


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE RATS
                       FIRST TERMINAL SACRIFICE AT 729 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = CONTROL                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 17     CENSORED DEATHS 0    TERMINAL 33        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      463   540   653   659   661   679   693   696   702   707                 |
 |      707   714   717   717   717   717   717                                   |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 1.5MG/M3                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 23     CENSORED DEATHS 0    TERMINAL 27        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      535   598   601   609   623   630   644   651   659   668                 |
 |      672   672   677   681   686   693   693   699   699   702                 |
 |      710   717   720                                                           |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 5.0MG/M3                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 18     CENSORED DEATHS 0    TERMINAL 32        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      500   556   560   566   611   630   630   637   644   650                 |
 |      672   674   695   703   707   714   717   718                             |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================

                                  EPINEPHRINE HCL


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE RATS
                       FIRST TERMINAL SACRIFICE AT 729 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   729 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |CONTROL    |   100.0 100.0 100.0 100.0 100.0  98.0  96.0  96.0  90.0  66.0      |
 |           |                                                                    |
 |           |                                                                    |
 |1.5MG/M3   |   100.0 100.0 100.0 100.0 100.0 100.0  98.0  94.0  82.0  54.0      |
 |           |                                                                    |
 |           |                                                                    |
 |5.0MG/M3   |   100.0 100.0 100.0 100.0 100.0 100.0  98.0  92.0  80.0  64.0      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                    DOSE                        |
 |                                                                                |
 |                                CONTROL          1.5MG/M3         5.0MG/M3      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       66.0%            54.0%            64.0%         |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=0.959          P=0.178          P=0.773       |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       674.1            662.6            643.6         |
 |NATURAL DEATHS (C)      |       (16.9)           ( 9.5)           (15.2)        |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       710.3            698.4            698.2         |
 |(STANDARD ERROR)        |       ( 6.8)           ( 6.4)           ( 7.9)        |
 |                        |                                                       |
 ==================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                                  EPINEPHRINE HCL


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE RATS
                       FIRST TERMINAL SACRIFICE AT 729 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = CONTROL                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 18     CENSORED DEATHS 0    TERMINAL 32        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      258   476   476   577   582   603   624   637   644   651                 |
 |      670   671   671   682   693   714   715   715                             |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 1.5MG/M3                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 21     CENSORED DEATHS 0    TERMINAL 29        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      126   430   524   528   535   553   553   581   623   651                 |
 |      653   679   679   714   714   714   717   717   717   720                 |
 |      720                                                                       |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 5.0MG/M3                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 20     CENSORED DEATHS 0    TERMINAL 30        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      356   572   581   615   622   622   637   644   654   657                 |
 |      662   665   679   679   682   715   715   720   725   727                 |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================

                                  EPINEPHRINE HCL


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE RATS
                       FIRST TERMINAL SACRIFICE AT 729 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   729 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |CONTROL    |   100.0 100.0  98.0  98.0  98.0  94.0  94.0  88.0  80.0  64.0      |
 |           |                                                                    |
 |           |                                                                    |
 |1.5MG/M3   |   100.0  98.0  98.0  98.0  98.0  96.0  90.0  84.0  78.0  58.0      |
 |           |                                                                    |
 |           |                                                                    |
 |5.0MG/M3   |   100.0 100.0 100.0  98.0  98.0  98.0  98.0  94.0  76.0  60.0      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                    DOSE                        |
 |                                                                                |
 |                                CONTROL          1.5MG/M3         5.0MG/M3      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       64.0%            58.0%            60.0%         |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=0.962          P=0.735          P=0.902       |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       614.4            611.8            646.5         |
 |NATURAL DEATHS (C)      |       (26.9)           (30.8)           (18.4)        |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       687.7            679.8            696.0         |
 |(STANDARD ERROR)        |       (12.3)           (15.2)           ( 9.3)        |
 |                        |                                                       |
 ==================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                                                          EPINEPHRINE HCL
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        CONTROL          = 1
                                                        1.5MG/M3         = 2
                                                        5.0MG/M3         = 3

------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  100 + 1                                                                         1    3     2
      |
      |                                                                           1    3     21 3      2
      |                                                                                       1                1
   95 +
      |                                                                                         33     22      1 1
      |                                                                                          3      232
      |
   90 +                                                                                                  322     1 1
      |
      |                                                                                                    2 2     1 1
      |                                                                                                    3322      11
P  85 +
E     |                                                                                                     332  2    11
R     |                                                                                                      33  22
C     |
E  80 +                                                                                                       3   3
N     |
T     |                                                                                                           33   11
      |                                                                                                           22  3 11
S  75 +
U     |                                                                                                            22 33
R     |
V     |
I  70 +                                                                                                             22 33
V     |
A     |                                                                                                                 33
L     |                                                                                                              22  1  1
   65 +
      |                                                                                                                  3  3
      |                                                                                                               22
      |
   60 +                                                                                                                22
      |
      |                                                                                                                 22
      |
   55 +
      |                                                                                                                  2  2
      |
      |
   50 +
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 4 obs hidden.

                                                          EPINEPHRINE HCL
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        CONTROL          = 1
                                                        1.5MG/M3         = 2
                                                        5.0MG/M3         = 3

----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  100 + 1                   2                    1              3
      |
      |                     2                    1              3           2      1              3
      |                                                                     2              2      33
   95 +
      |                                                                            1       22      1     3
      |                                                                                     22     11    33
      |
   90 +                                                                                      2 2    1   1
      |
P     |                                                                                                 1 313
E     |                                                                                        2   2       113
R  85 +
C     |                                                                                            2      2 11 3
E     |                                                                                                   2  11
N     |
T  80 +                                                                                                       12 31
      |
S     |                                                                                                        2   2
U     |                                                                                                          3 3
R  75 +
V     |                                                                                                           121   2
I     |                                                                                                            311
V     |
A  70 +                                                                                                             31  13
L     |
      |                                                                                                                 11
      |
   65 +
      |                                                                                                                  13 1
      |
      |
   60 +                                                                                                                   3 3
      |
      |                                                                                                                  2  2
      |
   55 +
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 12 obs hidden.

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