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TR 381 Mouse Pathology Tables


                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                              CARVONE


NTP Experiment-Test: 05032-02                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 09/04/94
Route: GAVAGE                                                                                                     Time: 19:21:15




       Facility:  International Research and Development Corp.

       Chemical CAS #:  99490

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05032-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                              CARVONE                                          Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 19:21:15  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        VEHICLE      375          750                                                    
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Moribund                                          23            9            4                                                  
    Dead                                              13           10            7                                                  
    Accident                                                        2            1                                                  
  Survivors                                                                                                                         
    Moribund                                                        1                                                               
    Terminal Sacrifice                                14           28           38                                                  
  Animals Examined Microscopically                    50           50           50                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (31)         (34)         (42)                                                
   Intestine Large, Cecum                             (46)         (44)         (46)                                                
   Intestine Large, Colon                             (48)         (47)         (47)                                                
   Intestine Small, Jejunum                           (41)         (40)         (47)                                                
   Liver                                              (50)         (50)         (50)                                                
      Hepatocellular Carcinoma                                      2 (4%)       1 (2%)                                             
      Hepatocellular Adenoma                           1 (2%)                                                                       
      Sarcoma, Metastatic, Skeletal Muscle                                       1 (2%)                                             
   Mesentery                                          (20)         (12)         (2)                                                 
      Sarcoma, Metastatic, Skin                                     1 (8%)                                                          
      Fat, Sarcoma, Metastatic, Skeletal Muscle                                  1 (50%)                                            
   Pancreas                                           (49)         (49)         (49)                                                
      Parenchyma, Sarcoma, Metastatic, Skin                         1 (2%)                                                          
      Parenchyma, Sarcoma, Metastatic, Skeletal                                                                                     
          Muscle                                                                 1 (2%)                                             
   Stomach, Forestomach                               (47)         (47)         (49)                                                
      Squamous Cell Carcinoma                                       1 (2%)                                                          
      Squamous Cell Papilloma                                       3 (6%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (50)         (49)         (50)                                                
      Capsule, Sarcoma, Metastatic, Skin                            1 (2%)                                                          
   Adrenal Gland, Cortex                              (50)         (49)         (50)                                                
      Sarcoma, Metastatic, Skeletal Muscle                                       1 (2%)                                             
                                                             Page   2                                                               
NTP Experiment-Test: 05032-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                              CARVONE                                          Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 19:21:15  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        VEHICLE      375          750                                                    
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - cont                                                                                                             
   Pituitary Gland                                    (46)         (49)         (48)                                                
      Adenoma                                          1 (2%)                    1 (2%)                                             
      Pars Distalis, Adenoma                                                     1 (2%)                                             
   Thyroid Gland                                      (49)         (46)         (50)                                                
      Adenoma                                                                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (50)         (48)         (48)                                                
      Adenoma, Papillary                               1 (2%)                                                                       
   Uterus                                             (50)         (50)         (50)                                                
      Leiomyosarcoma                                                             1 (2%)                                             
      Polyp                                                                      2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node                                         (47)         (47)         (48)                                                
      Mediastinal, Sarcoma                                                       1 (2%)                                             
      Pancreatic, Leiomyosarcoma, Metastatic,                                                                                       
          Uterus                                                                 1 (2%)                                             
   Lymph Node, Mesenteric                             (46)         (47)         (48)                                                
      Sarcoma, Metastatic                                                        1 (2%)                                             
      Sarcoma, Metastatic, Skin                                     1 (2%)                                                          
   Spleen                                             (50)         (49)         (50)                                                
      Capsule, Sarcoma, Metastatic, Skin                            1 (2%)                                                          
      Capsule, Sarcoma, Metastatic, Skeletal Muscle                              1 (2%)                                             
   Thymus                                             (35)         (42)         (46)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (48)         (46)         (42)                                                
      Adenocarcinoma                                   1 (2%)                    1 (2%)                                             
   Skin                                               (16)         (34)         (14)                                                
      Subcutaneous Tissue, Sarcoma                                  1 (3%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   3                                                               
NTP Experiment-Test: 05032-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                              CARVONE                                          Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 19:21:15  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        VEHICLE      375          750                                                    
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                    (1)          (1)          (2)                                                 
      Osteosarcoma, Metastatic, Uncertain Primary                                                                                   
          Site                                                      1 (100%)                                                        
      Back, Sarcoma                                                              1 (50%)                                            
      Diaphragm, Sarcoma, Metastatic, Skeletal                                                                                      
          Muscle                                                                 1 (50%)                                            
      Thigh, Sarcoma                                                             1 (50%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)                                                
      Alveolar/Bronchiolar Adenoma                     1 (2%)       6 (12%)      3 (6%)                                             
      Osteosarcoma, Metastatic, Uncertain Primary                                                                                   
          Site                                                      1 (2%)                                                          
      Parenchyma, Sarcoma, Metastatic, Skeletal                                                                                     
          Muscle                                                                 1 (2%)                                             
   Trachea                                            (49)         (50)         (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (2)                                                                           
      Adenoma                                          2 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)                                                
      Bilateral, Capsule, Sarcoma, Metastatic, Skin                 1 (2%)                                                          
      Renal Tubule, Adenoma                                         1 (2%)                                                          
   Urinary Bladder                                    (46)         (46)         (48)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)                                                
      Lymphoma Malignant Lymphocytic                   1 (2%)                                                                       
      Lymphoma Malignant Mixed                         1 (2%)       4 (8%)       4 (8%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   4                                                               
NTP Experiment-Test: 05032-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                              CARVONE                                          Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 19:21:15  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        VEHICLE      375          750                                                    
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)             9          14          14                                                   
     Total Primary Neoplasms                            9          18          18                                                   
                                                                                                                                    
   Total Animals with Benign Neoplasms                  6           8           7                                                   
     Total Benign Neoplasms                             6          10           8                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms               3           8           8                                                   
     Total Malignant Neoplasms                          3           8          10                                                   
                                                                                                                                    
   Total Animals with Metastatic Neoplasms                          2           2                                                   
     Total Metastatic Neoplasm                                      8           9                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms                           1                                                               
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   5                                                               
NTP Experiment-Test: 05032-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                              CARVONE                                          Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 19:21:15  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          VEHICLE      375          750                                                    
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Dead                                               6            6            7                                                  
    Moribund                                           7            2            3                                                  
    Accident                                                                     4                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                37           42           36                                                  
  Animals Examined Microscopically                    50           50           50                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (50)         (50)         (49)                                                
      Periesophageal Tissue, Alveolar/Bronchiolar                                                                                   
          Carcinoma, Metastatic, Lung                                            1 (2%)                                             
   Gallbladder                                        (38)         (36)         (43)                                                
      Carcinoma, Metastatic, Uncertain Primary Site                              1 (2%)                                             
   Intestine Large, Cecum                             (50)         (46)         (49)                                                
   Intestine Small, Ileum                             (49)         (49)         (48)                                                
   Intestine Small, Jejunum                           (48)         (48)         (48)                                                
   Liver                                              (50)         (50)         (49)                                                
      Hepatocellular Carcinoma                         5 (10%)      3 (6%)       3 (6%)                                             
      Hepatocellular Adenoma                           2 (4%)       4 (8%)       4 (8%)                                             
   Pancreas                                           (50)         (50)         (48)                                                
      Carcinoma, Metastatic, Uncertain Primary Site                              1 (2%)                                             
      Sarcoma, Metastatic, Lymph Node                  1 (2%)                                                                       
   Salivary Glands                                    (50)         (50)         (50)                                                
   Stomach, Forestomach                               (48)         (48)         (47)                                                
      Squamous Cell Papilloma                          1 (2%)       1 (2%)                                                          
   Stomach, Glandular                                 (49)         (49)         (48)                                                
      Carcinoma, Metastatic, Uncertain Primary Site                              1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)                                                
      Epicardium, Alveolar/Bronchiolar Carcinoma,                                                                                   
           Metastatic, Lung                                                      1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   6                                                               
NTP Experiment-Test: 05032-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                              CARVONE                                          Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 19:21:15  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          VEHICLE      375          750                                                    
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Medulla                             (48)         (49)         (48)                                                
      Pheochromocytoma Benign                          1 (2%)                                                                       
      Bilateral, Pheochromocytoma Benign               1 (2%)                                                                       
   Pituitary Gland                                    (40)         (48)         (48)                                                
   Thyroid Gland                                      (50)         (50)         (49)                                                
      Follicular Cell, Adenoma                         1 (2%)                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (50)         (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (49)                                                
   Lymph Node                                         (50)         (50)         (49)                                                
      Mediastinal, Alveolar/Bronchiolar Carcinoma,                                                                                  
           Metastatic, Lung                                                      1 (2%)                                             
   Lymph Node, Mesenteric                             (50)         (50)         (48)                                                
      Hemangioma                                       1 (2%)                                                                       
      Sarcoma                                          1 (2%)                                                                       
   Spleen                                             (50)         (50)         (48)                                                
      Hemangiosarcoma                                  1 (2%)                                                                       
   Thymus                                             (44)         (42)         (44)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (26)         (45)         (15)                                                
      Back, Subcutaneous Tissue, Fibroma               2 (8%)                    1 (7%)                                             
      Prepuce, Squamous Cell Carcinoma                 1 (4%)                                                                       
      Subcutaneous Tissue, Fibrosarcoma                1 (4%)                                                                       
      Subcutaneous Tissue, Hemangioma                  1 (4%)                                                                       
      Subcutaneous Tissue, Neurofibrosarcoma           2 (8%)       1 (2%)                                                          
      Subcutaneous Tissue, Sarcoma                     4 (15%)                   2 (13%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   7                                                               
NTP Experiment-Test: 05032-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                              CARVONE                                          Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 19:21:15  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          VEHICLE      375          750                                                    
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                    (1)                                                                           
      Fibrosarcoma, Metastatic, Skin                   1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)                                                
      Alveolar/Bronchiolar Adenoma                     7 (14%)      4 (8%)       5 (10%)                                            
      Alveolar/Bronchiolar Carcinoma                                1 (2%)       1 (2%)                                             
      Carcinoma, Metastatic, Uncertain Primary Site                              1 (2%)                                             
      Hepatocellular Carcinoma, Metastatic, Liver                                1 (2%)                                             
   Nose                                               (50)         (50)         (49)                                                
   Trachea                                            (50)         (50)         (49)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (1)          (2)          (1)                                                 
      Adenoma                                          1 (100%)     2 (100%)     1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (49)                                                
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                  1 (2%)                                             
      Glomerulus, Carcinoma, Metastatic, Uncertain                                                                                  
          Primary Site                                                           1 (2%)                                             
      Renal Tubule, Adenoma                                                      1 (2%)                                             
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)                                                
      Lymphoma Malignant Histiocytic                                1 (2%)                                                          
      Lymphoma Malignant Lymphocytic                   1 (2%)                                                                       
      Lymphoma Malignant Mixed                         4 (8%)       1 (2%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   8                                                               
NTP Experiment-Test: 05032-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                              CARVONE                                          Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 19:21:15  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          VEHICLE      375          750                                                    
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            27          15          16                                                   
     Total Primary Neoplasms                           38          18          20                                                   
                                                                                                                                    
   Total Animals with Benign Neoplasms                 17          10          10                                                   
     Total Benign Neoplasms                            18          11          13                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms              17           7           7                                                   
     Total Malignant Neoplasms                         20           7           7                                                   
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              2                       2                                                   
     Total Metastatic Neoplasm                          2                      10                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                       1                                                   
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   9                                                               
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