National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/3033

TR 381 Mouse Pathology Tables

NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11 
LAB: IRDC                                                      DATE: 09/04/94   
EXP: 05032                         CARVONE                     TIME: 19:33:46   
TEST: 02              CAGES FROM 0000 TO LAST CAGE             PAGE:   1        
TEST TYPE: CHRONIC          ROUTE: GAVAGE                      NTP C#: 55867A   
CONT:                                                          CAS: 99490       
PATHOLOGIST: DR. A. BOOTHE                   S. EUSTIS                          
--------------------------------------------------------------------------------
                                                                                
                                                                                
                                                                                


REASONS FOR REMOVAL:                                                            
                                                                                
ALL                                                                             
                                                                                
                                                                                
REMOVAL DATE RANGE:                                                             


ALL                                                                             
                                                                                
TREATMENT GROUPS:                                                               
                                                                                
INCLUDE ALL                                                                     

NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11
LAB: IRDC                                                      DATE: 09/04/94  
EXP: 05032                         CARVONE                     TIME: 19:33:46  
TEST: 02              CAGES FROM 0000 TO LAST CAGE                             
TEST TYPE: CHRONIC          ROUTE: GAVAGE                      NTP C#: 55867A  
CONT:                                                          CAS: 99490      
PATHOLOGIST: DR. A. BOOTHE                   S. EUSTIS                         

                                      CARVONE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 729 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                          DOSE = VEHICLE CONTROL                                |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 13     CENSORED DEATHS 0    TERMINAL 37        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      200   289   337   466   504   577   592   622   637   670                 |
 |      680   687   699                                                           |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = 375     MG/KG                                  |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 8      CENSORED DEATHS 0    TERMINAL 42        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      207   329   407   525   552   663   669   714                             |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = 750     MG/KG                                  |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 10     CENSORED DEATHS 4    TERMINAL 36        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      130   175   332   401   461   592   602   695   707   718                 |
 |  CENSORED DEATHS                                                               |
 |      3     3     4     498                                                     |
 |                                                                                |
 ==================================================================================

                                      CARVONE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 729 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   729 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |VEHICLE    |   100.0 100.0  98.0  94.0  94.0  92.0  90.0  86.0  82.0  74.0      |
 |CONTROL    |                                                                    |
 |           |                                                                    |
 |375        |   100.0 100.0  98.0  96.0  94.0  94.0  92.0  90.0  88.0  84.0      |
 |MG/KG      |                                                                    |
 |           |                                                                    |
 |750        |   100.0  95.7  95.7  93.6  91.5  89.4  89.4  85.0  85.0  78.5      |
 |MG/KG      |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                    DOSE                        |
 |                                                                                |
 |                                VEHICLE          375              750           |
 |                                CONTROL          MG/KG            MG/KG         |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       74.0%            84.0%            78.5%         |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=0.675N         P=0.329N         P=0.784N      |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       535.4            508.3            481.3         |
 |NATURAL DEATHS (C)      |       (46.0)           (63.7)           (68.8)        |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       678.7            693.7            631.3         |
 |(STANDARD ERROR)        |       (16.8)           (15.0)           (29.9)        |
 |                        |                                                       |
 ==================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                                      CARVONE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 729 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                          DOSE = VEHICLE CONTROL                                |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 36     CENSORED DEATHS 0    TERMINAL 14        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      407   417   420   436   465   483   491   522   533   533                 |
 |      565   576   579   591   598   609   610   627   638   643                 |
 |      645   653   658   670   676   681   692   693   693   695                 |
 |      705   707   708   708   709   709                                         |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = 375     MG/KG                                  |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 19     CENSORED DEATHS 2    TERMINAL 29        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      312   435   489   491   550   565   580   582   597   608                 |
 |      612   625   626   642   645   659   673   693   707                       |
 |  CENSORED DEATHS                                                               |
 |      2     379                                                                 |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = 750     MG/KG                                  |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 11     CENSORED DEATHS 1    TERMINAL 38        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      374   389   535   539   539   549   570   610   615   690                 |
 |      692                                                                       |
 |  CENSORED DEATHS                                                               |
 |      3                                                                         |
 |                                                                                |
 ==================================================================================

                                      CARVONE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 729 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   729 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |VEHICLE    |   100.0 100.0 100.0 100.0  94.0  88.0  80.0  70.0  54.0  28.0      |
 |CONTROL    |                                                                    |
 |           |                                                                    |
 |375        |   100.0 100.0 100.0  98.0  98.0  95.9  91.7  81.3  66.7  60.4      |
 |MG/KG      |                                                                    |
 |           |                                                                    |
 |750        |   100.0 100.0 100.0 100.0  95.9  95.9  89.8  85.7  81.6  77.6      |
 |MG/KG      |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                    DOSE                        |
 |                                                                                |
 |                                VEHICLE          375              750           |
 |                                CONTROL          MG/KG            MG/KG         |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       28.0%            60.4%            77.6%         |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P<0.001          P=0.006N         P<0.001       |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       604.0            583.7            554.7         |
 |NATURAL DEATHS (C)      |       (16.1)           (22.2)           (30.9)        |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       639.0            652.3            676.1         |
 |(STANDARD ERROR)        |       (14.0)           (19.4)           (18.4)        |
 |                        |                                                       |
 ==================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                                                              CARVONE
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        VEHICLE CONTROL  = 1
                                                        375     MG/KG    = 2
                                                        750     MG/KG    = 3

------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  100 + 1                    3          12
      |
      |                      3      3   12            1     2
      |                             3                 1     231          2
P  95 +
E     |                                                      31         32        1        2
R     |                                                                           1    1   2   2
C     |                                                                 3        3
E  90 +                                                                                1       2   1             2
N     |                                                                          3                    3
T     |                                                                                            1  13         22
      |                                                                                               1   1       2     2
S  85 +                                                                                                3              3
U     |                                                                                                   1 1           2   2
R     |                                                                                                     1     1   33
V     |                                                                                                                3 3
I  80 +                                                                                                           1 1
V     |                                                                                                                  3  3
A     |                                                                                                             11
L     |                                                                                                              11
   75 +
      |                                                                                                               1     1
      |
      |
   70 +
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 3 obs hidden.

                                                              CARVONE
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        VEHICLE CONTROL  = 1
                                                        375     MG/KG    = 2
                                                        750     MG/KG    = 3

----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  100 + 1                                                 2        3     1
      |                                                   2        3  3  11  2
      |                                                               3   1  1       22      3
      |                                                                      1    1   2        2
   90 +                                                                           1 1        3 2 2
      |                                                                             1 1        3 232
      |                                                                               1    1 1    322    3
      |                                                                                             2  223           3
P  80 +                                                                                      1   1      22
E     |                                                                                          1 1     2 2         3      3
R     |                                                                                            1  1
C     |                                                                                               11   2 2
E  70 +                                                                                                11    22  2
N     |                                                                                                 11       2 2
T     |                                                                                                  1 1 1     2 2
      |                                                                                                              2 2
S  60 +                                                                                                      11        2    2
U     |                                                                                                       11
R     |                                                                                                        1  1
V     |                                                                                                           11
I  50 +                                                                                                            11
V     |                                                                                                             11
A     |
L     |                                                                                                              11
   40 +                                                                                                               11
      |
      |                                                                                                                11
      |
   30 +
      |                                                                                                                 1   1
      |
      |
   20 +
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 9 obs hidden.

--multipart-boundary
Content-type: text/plain
Range: bytes 24731-24731/24731


--multipart-boundary--
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.