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https://ntp.niehs.nih.gov/go/3092

TR 382 Mouse Pathology Tables


                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                                              FURFURAL


NTP Experiment-Test: 05005-08                                                                                     Report: PEIRPT03
Study Type: CHRONIC                                                                                               Date: 09/03/94
Route: GAVAGE                                                                                                     Time: 06:46:15




       Facility:  Southern Research Institute

       Chemical CAS #:  98-01-1

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05005-08         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                              FURFURAL                                         Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 06:46:15  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        VEHICLE      50.          100.         175.                                      
                                                   CONTROL      MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Moribund                                           8           11            9            7                                     
    Dead                                               8            8           11           11                                     
    Dosing Accident                                    1                                                                            
    Natural Death                                                   1            1                                                  
    Accident                                                        2                                                               
  Survivors                                                                                                                         
    Terminal Sacrifice                                32           28           29           32                                     
    Terminal Sacrifice                                 1                                                                            
  Animals Examined Microscopically                    50           50           50           50                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (46)         (46)         (48)         (43)                                   
      Infiltration Cellular, Multifocal, Lymphocyte                 1 (2%)                    1 (2%)                                
   Intestine Small, Jejunum                           (48)         (48)         (46)         (50)                                   
      Inflammation, Focal, Subacute                                              1 (2%)                                             
   Liver                                              (50)         (50)         (50)         (50)                                   
      Abscess                                          1 (2%)                    1 (2%)                                             
      Angiectasis, Focal                                            1 (2%)                                                          
      Focal Cellular Change                            1 (2%)       2 (4%)       2 (4%)       2 (4%)                                
      Granuloma, Multiple                              1 (2%)       3 (6%)       1 (2%)                                             
      Hematopoietic Cell Proliferation                 5 (10%)      4 (8%)       1 (2%)       4 (8%)                                
      Infiltration Cellular, Megakaryocyte                          1 (2%)                                                          
      Infiltration Cellular, Lymphocyte                                          1 (2%)                                             
      Necrosis, Focal                                  2 (4%)                                                                       
      Necrosis, Multifocal                                          1 (2%)       3 (6%)       2 (4%)                                
      Vacuolization Cytoplasmic, Diffuse                            1 (2%)                    1 (2%)                                
      Kupffer Cell, Hyperplasia                                     1 (2%)                                                          
      Kupffer Cell, Pigmentation, Multifocal                        1 (2%)       1 (2%)                                             
      Serosa, Subserosa, Inflammation, Chronic,                                                                                     
           Multifocal                                                                         6 (12%)                               
      Serosa, Subserosa, Pigmentation, Multifocal                                            10 (20%)                               
      Sinusoid, Infiltration Cellular,                                                                                              
          Polymorphonuclear                            6 (12%)      3 (6%)      14 (28%)      2 (4%)                                
      Subserosa, Inflammation, Chronic, Multifocal                               1 (2%)       2 (4%)                                
      Subserosa, Pigmentation, Multifocal                                                     1 (2%)                                
   Mesentery                                          (6)          (10)         (7)          (11)                                   
      Abscess                                          1 (17%)                                                                      
      Inflammation, Acute, Suppurative                 2 (33%)                   3 (43%)      2 (18%)                               
      Inflammation, Subacute                                        1 (10%)                   1 (9%)                                
      Fat, Necrosis, Focal                             2 (33%)      1 (10%)      3 (43%)      7 (64%)                               
      Fat, Necrosis, Multifocal                                     1 (10%)                                                         
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05005-08         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                              FURFURAL                                         Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 06:46:15  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        VEHICLE      50.          100.         175.                                      
                                                   CONTROL      MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
   Pancreas                                           (50)         (50)         (48)         (50)                                   
      Infiltration Cellular, Multifocal, Lymphocyte    6 (12%)      6 (12%)      5 (10%)     10 (20%)                               
      Inflammation, Acute, Suppurative                              2 (4%)       4 (8%)                                             
      Acinus, Atrophy, Focal                                        1 (2%)                                                          
      Acinus, Atrophy, Multifocal                      1 (2%)       5 (10%)      1 (2%)                                             
      Acinus, Necrosis, Focal                                       1 (2%)                                                          
      Duct, Cyst                                       2 (4%)       3 (6%)                                                          
      Duct, Dilatation                                                           1 (2%)                                             
   Salivary Glands                                    (50)         (50)         (50)         (50)                                   
      Atrophy, Focal                                                1 (2%)                                                          
      Hyperplasia, Focal                                            1 (2%)                                                          
      Infiltration Cellular, Multifocal, Lymphocyte   24 (48%)     22 (44%)     21 (42%)     23 (46%)                               
      Pigmentation, Focal, Hemosiderin                              1 (2%)                                                          
   Stomach, Forestomach                               (50)         (50)         (50)         (50)                                   
      Cyst Epithelial Inclusion                                     1 (2%)                                                          
      Hyperkeratosis, Focal                                         1 (2%)                                                          
      Hyperplasia                                                   5 (10%)      5 (10%)      3 (6%)                                
      Inflammation, Subacute                                        3 (6%)       4 (8%)                                             
      Mineralization                                                                          1 (2%)                                
      Ulcer                                                         1 (2%)       1 (2%)                                             
   Stomach, Glandular                                 (50)         (50)         (50)         (50)                                   
      Erosion, Multiple                                                          1 (2%)                                             
      Inflammation, Subacute                           1 (2%)       1 (2%)                    2 (4%)                                
      Mineralization                                                1 (2%)       2 (4%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)         (50)                                   
      Angiectasis, Focal                                            1 (2%)                                                          
      Inflammation, Acute, Focal                                                 1 (2%)                                             
      Inflammation, Focal, Subacute                                 2 (4%)       1 (2%)                                             
      Mineralization, Multifocal                                    1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (50)         (50)         (50)                                   
      Degeneration, Fatty, Focal                       1 (2%)                                                                       
      Hematopoietic Cell Proliferation                                           2 (4%)                                             
      Hyperplasia, Focal                               1 (2%)                    2 (4%)       2 (4%)                                
      Hypertrophy, Focal                                                         1 (2%)                                             
      Capsule, Accessory Adrenal Cortical Nodule                                              1 (2%)                                
      Spindle Cell, Hyperplasia, Focal                                           2 (4%)                                             
   Adrenal Gland, Medulla                             (50)         (50)         (50)         (50)                                   
      Hyperplasia, Focal                                            2 (4%)       2 (4%)       1 (2%)                                
   Islets, Pancreatic                                 (50)         (50)         (48)         (50)                                   
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05005-08         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                              FURFURAL                                         Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 06:46:15  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        VEHICLE      50.          100.         175.                                      
                                                   CONTROL      MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Hyperplasia                                      1 (2%)       2 (4%)       3 (6%)       2 (4%)                                
   Parathyroid Gland                                  (48)         (45)         (45)         (44)                                   
      Cyst                                             1 (2%)                                                                       
   Pituitary Gland                                    (46)         (49)         (49)         (49)                                   
      Pars Distalis, Angiectasis                       5 (11%)      5 (10%)      6 (12%)     11 (22%)                               
      Pars Distalis, Cyst                                           1 (2%)       1 (2%)       1 (2%)                                
      Pars Distalis, Hyperplasia, Focal               12 (26%)     14 (29%)      9 (18%)      6 (12%)                               
      Pars Distalis, Pigmentation, Hemosiderin         1 (2%)                                                                       
   Thyroid Gland                                      (50)         (50)         (49)         (50)                                   
      Ultimobranchial Cyst                                          1 (2%)                                                          
      C-Cell, Hyperplasia, Focal                       2 (4%)                    1 (2%)                                             
      Follicle, Cyst                                   2 (4%)       1 (2%)       3 (6%)       4 (8%)                                
      Follicle, Degeneration, Cystic                  14 (28%)     13 (26%)     11 (22%)     12 (24%)                               
      Follicular Cell, Hyperplasia, Cystic, Focal      2 (4%)       2 (4%)                    3 (6%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (48)         (49)         (50)         (50)                                   
      Abscess                                          9 (19%)      6 (12%)     15 (30%)      3 (6%)                                
      Angiectasis                                                   1 (2%)                                                          
      Cyst                                             7 (15%)     11 (22%)      9 (18%)     12 (24%)                               
      Cyst, Two                                        1 (2%)       1 (2%)                                                          
      Hemorrhage                                                                              1 (2%)                                
      Hyperplasia, Tubular                             1 (2%)                    1 (2%)                                             
      Infiltration Cellular, Multifocal, Lymphocyte                              1 (2%)                                             
   Uterus                                             (50)         (50)         (50)         (50)                                   
      Angiectasis                                                   3 (6%)                    1 (2%)                                
      Cyst                                                                       1 (2%)                                             
      Hydrometra                                       6 (12%)      6 (12%)      3 (6%)       2 (4%)                                
      Inflammation, Acute, Suppurative                 2 (4%)       4 (8%)       8 (16%)      2 (4%)                                
      Endometrium, Hyperplasia, Cystic                43 (86%)     42 (84%)     44 (88%)     48 (96%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Blood                                              (2)          (2)          (1)          (1)                                    
      Leukocytosis                                     1 (50%)      1 (50%)      1 (100%)     1 (100%)                              
      Polychromasia                                                 1 (50%)      1 (100%)                                           
   Bone Marrow                                        (50)         (49)         (49)         (50)                                   
      Hyperplasia                                      8 (16%)     13 (27%)     11 (22%)      8 (16%)                               
      Infiltration Cellular, Megakaryocyte                          1 (2%)                                                          
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05005-08         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                              FURFURAL                                         Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 06:46:15  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        VEHICLE      50.          100.         175.                                      
                                                   CONTROL      MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
   Lymph Node                                         (50)         (50)         (50)         (50)                                   
      Iliac, Hyperplasia, Lymphoid                     1 (2%)       3 (6%)       1 (2%)       1 (2%)                                
      Mediastinal, Hyperplasia, Lymphoid               1 (2%)                    1 (2%)       1 (2%)                                
      Mediastinal, Inflammation, Acute, Suppurative                 1 (2%)       1 (2%)                                             
      Renal, Hyperplasia, Lymphoid                     2 (4%)       5 (10%)      5 (10%)      1 (2%)                                
   Lymph Node, Mandibular                             (47)         (47)         (49)         (48)                                   
      Hyperplasia, Lymphoid                                         1 (2%)                    7 (15%)                               
      Infiltration Cellular, Megakaryocyte                          1 (2%)                                                          
   Lymph Node, Mesenteric                             (48)         (46)         (49)         (48)                                   
      Angiectasis                                                   2 (4%)                                                          
      Hyperplasia, Lymphoid                           12 (25%)      9 (20%)     13 (27%)     13 (27%)                               
      Infiltration Cellular, Megakaryocyte                          1 (2%)                                                          
   Spleen                                             (50)         (50)         (50)         (50)                                   
      Atrophy                                                       1 (2%)       1 (2%)       1 (2%)                                
      Hematopoietic Cell Proliferation                16 (32%)     17 (34%)     19 (38%)     11 (22%)                               
      Hyperplasia, Lymphoid                            1 (2%)                    1 (2%)                                             
      Infiltration Cellular, Megakaryocyte                          1 (2%)                                                          
   Thymus                                             (49)         (47)         (44)         (46)                                   
      Cyst                                                          4 (9%)       2 (5%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (50)         (50)         (48)                                   
      Duct, Cyst                                       4 (8%)       1 (2%)       2 (4%)       2 (4%)                                
   Skin                                               (50)         (50)         (50)         (50)                                   
      Subcutaneous Tissue, Fibrosis, Focal                                                    1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)                                   
      Femur, Fracture                                               1 (2%)                                                          
   Skeletal Muscle                                    (1)          (3)          (1)                                                 
      Inflammation, Acute, Suppurative                                           1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)                                   
      Compression                                                                             1 (2%)                                
      Granuloma                                                     1 (2%)                                                          
      Hemorrhage, Focal                                             1 (2%)                    1 (2%)                                
      Meninges, Inflammation, Acute, Suppurative       1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05005-08         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                              FURFURAL                                         Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 06:46:15  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        VEHICLE      50.          100.         175.                                      
                                                   CONTROL      MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)                                   
      Congestion                                                    1 (2%)                                                          
      Hemorrhage, Focal                                1 (2%)                                                                       
      Infiltration Cellular, Megakaryocyte                          1 (2%)                                                          
      Infiltration Cellular, Multifocal, Histiocyte    2 (4%)                                                                       
      Infiltration Cellular, Polymorphonuclear                                   1 (2%)                                             
      Inflammation, Acute, Multifocal, Suppurative                               1 (2%)                                             
      Pigmentation, Hemosiderin, Multifocal                                                   1 (2%)                                
      Alveolar Epithelium, Hyperplasia, Focal                       1 (2%)                    1 (2%)                                
      Mediastinum, Foreign Body                        1 (2%)                                                                       
      Mediastinum, Inflammation, Acute, Suppurative    3 (6%)       2 (4%)       3 (6%)                                             
      Mediastinum, Inflammation, Subacute                                                     1 (2%)                                
   Nose                                               (50)         (50)         (50)         (50)                                   
      Foreign Body                                                               1 (2%)                                             
      Inflammation, Acute, Suppurative                              1 (2%)                                                          
      Nasolacrimal Duct, Foreign Body                  1 (2%)                                                                       
      Nasolacrimal Duct, Inflammation, Subacute        4 (8%)       5 (10%)      4 (8%)       2 (4%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                             (1)                                                              
      Cataract                                                      1 (100%)                                                        
      Hyperplasia, Melanocyte                                       1 (100%)                                                        
   Harderian Gland                                                 (1)          (1)          (2)                                    
      Cyst                                                                       1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (50)                                   
      Amyloid Deposition                                                                      1 (2%)                                
      Fibrosis, Focal                                               3 (6%)                    2 (4%)                                
      Inflammation, Acute, Multifocal, Suppurative     1 (2%)       1 (2%)       1 (2%)                                             
      Metaplasia, Focal, Osseous                       1 (2%)       2 (4%)                                                          
      Nephropathy, Chronic                            24 (48%)     33 (66%)     33 (66%)     35 (70%)                               
      Renal Tubule, Degeneration, Multifocal                        1 (2%)                                                          
      Renal Tubule, Dilatation, Multifocal                                       1 (2%)       1 (2%)                                
      Renal Tubule, Mineralization, Multifocal                      1 (2%)                                                          
      Renal Tubule, Pigmentation, Hemosiderin,                                                                                      
           Multifocal                                                                         1 (2%)                                
   Urinary Bladder                                    (50)         (50)         (50)         (50)                                   
      Infiltration Cellular, Multifocal, Lymphocyte    7 (14%)      8 (16%)      9 (18%)      6 (12%)                               
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05005-08         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                              FURFURAL                                         Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 06:46:15  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        VEHICLE      50.          100.         175.                                      
                                                   CONTROL      MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Inflammation, Subacute                                        1 (2%)                                                          
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 05005-08         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                              FURFURAL                                         Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 06:46:15  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          VEHICLE      50.          100.         175.                                      
                                                   CONTROL      MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Dead                                               9           12           13            8                                     
    Moribund                                           6            8           12            8                                     
    Natural Death                                                                             1                                     
    Accident                                                                                  1                                     
    Accidently Killed                                                                         5                                     
    Dosing Accident                                                 2                                                               
  Survivors                                                                                                                         
    Terminal Sacrifice                                35           28           24           27                                     
  Missing                                                                        1                                                  
  Animals Examined Microscopically                    50           50           49           50                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (50)         (49)         (49)         (50)                                   
      Foreign Body                                                  1 (2%)                                                          
      Inflammation, Acute, Suppurative                              1 (2%)                                                          
   Intestine Large, Cecum                             (49)         (47)         (49)         (46)                                   
      Inflammation, Chronic                                         1 (2%)                                                          
   Intestine Small, Jejunum                           (47)         (46)         (47)         (45)                                   
      Perforation                                                                1 (2%)                                             
   Liver                                              (50)         (50)         (49)         (50)                                   
      Angiectasis, Focal                                                         1 (2%)                                             
      Basophilic Focus                                 1 (2%)                    1 (2%)                                             
      Congestion                                                                              1 (2%)                                
      Developmental Malformation                                                 1 (2%)                                             
      Embolus Tumor                                                 1 (2%)                                                          
      Fibrosis, Focal                                                            1 (2%)                                             
      Focal Cellular Change                            3 (6%)       7 (14%)      4 (8%)       5 (10%)                               
      Focal Cellular Change, Multiple                  1 (2%)                    1 (2%)                                             
      Granuloma, Multiple                              1 (2%)                    2 (4%)                                             
      Hematopoietic Cell Proliferation                              2 (4%)       2 (4%)       1 (2%)                                
      Hepatodiaphragmatic Nodule                                                 1 (2%)                                             
      Inclusion Body Intranuclear                                                             1 (2%)                                
      Infiltration Cellular, Multifocal, Lymphocyte    1 (2%)       2 (4%)       4 (8%)       1 (2%)                                
      Mineralization, Focal                                         1 (2%)                    1 (2%)                                
      Necrosis, Focal                                  2 (4%)                                 2 (4%)                                
      Necrosis, Multifocal                             1 (2%)       2 (4%)       7 (14%)      8 (16%)                               
      Pigmentation, Hematoidin                                      1 (2%)                                                          
      Vacuolization Cytoplasmic, Diffuse               1 (2%)                                 1 (2%)                                
      Vacuolization Cytoplasmic, Focal                              1 (2%)                                                          
      Vacuolization Cytoplasmic, Multifocal                                                   1 (2%)                                
      Biliary Tract, Cyst                                                        1 (2%)       1 (2%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
NTP Experiment-Test: 05005-08         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                              FURFURAL                                         Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 06:46:15  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          VEHICLE      50.          100.         175.                                      
                                                   CONTROL      MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Biliary Tract, Cyst Multilocular                                                        3 (6%)                                
      Biliary Tract, Dilatation                                     1 (2%)                    1 (2%)                                
      Biliary Tract, Proliferation                                  1 (2%)                                                          
      Biliary Tract, Subserosa, Hyperplasia,                                                                                        
          Multifocal                                                             3 (6%)       2 (4%)                                
      Centrilobular, Vacuolization Cytoplasmic,                                                                                     
           Diffuse                                                               1 (2%)                                             
      Kupffer Cell, Pigmentation, Multifocal                        2 (4%)                                                          
      Serosa, Subserosa, Inflammation, Chronic,                                                                                     
           Multifocal                                                            8 (16%)     18 (36%)                               
      Serosa, Subserosa, Pigmentation, Multifocal                                8 (16%)     18 (36%)                               
      Sinusoid, Infiltration Cellular,                                                                                              
          Polymorphonuclear                                         2 (4%)       1 (2%)                                             
   Mesentery                                          (4)          (3)          (5)          (5)                                    
      Inflammation, Granulomatous, Multifocal          1 (25%)                                                                      
      Fat, Necrosis, Focal                             2 (50%)      2 (67%)      2 (40%)      4 (80%)                               
   Pancreas                                           (50)         (50)         (49)         (49)                                   
      Infiltration Cellular, Multifocal, Lymphocyte                              1 (2%)                                             
      Necrosis, Multifocal                                          1 (2%)                                                          
      Acinus, Atrophy, Focal                           1 (2%)                                 1 (2%)                                
      Acinus, Atrophy, Multifocal                      1 (2%)       4 (8%)       1 (2%)       1 (2%)                                
      Duct, Cyst                                                    1 (2%)                                                          
   Salivary Glands                                    (50)         (50)         (49)         (50)                                   
      Infiltration Cellular, Multifocal, Lymphocyte   28 (56%)     21 (42%)     21 (43%)     24 (48%)                               
      Inflammation, Acute, Focal, Suppurative                       1 (2%)                                                          
   Stomach, Forestomach                               (50)         (49)         (49)         (49)                                   
      Erosion                                                       1 (2%)       1 (2%)                                             
      Foreign Body                                                               1 (2%)                                             
      Hyperplasia                                      5 (10%)      2 (4%)       8 (16%)      6 (12%)                               
      Inflammation, Subacute                           1 (2%)       2 (4%)       3 (6%)       2 (4%)                                
      Mineralization                                                                          1 (2%)                                
      Ulcer                                            1 (2%)                    1 (2%)                                             
      Ulcer, Multiple                                                            1 (2%)       1 (2%)                                
   Stomach, Glandular                                 (50)         (49)         (49)         (49)                                   
      Erosion, Multiple                                             1 (2%)                                                          
      Inflammation, Subacute                           3 (6%)       1 (2%)       1 (2%)                                             
      Mineralization                                   5 (10%)      3 (6%)       2 (4%)       3 (6%)                                
      Ulcer                                                                                   1 (2%)                                
   Tooth                                              (27)         (21)         (15)         (19)                                   
      Dysplasia                                       27 (100%)    20 (95%)     15 (100%)    19 (100%)                              
      Inflammation, Subacute                           1 (4%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    9                                                              
NTP Experiment-Test: 05005-08         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                              FURFURAL                                         Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 06:46:15  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          VEHICLE      50.          100.         175.                                      
                                                   CONTROL      MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (49)         (50)                                   
      Fibrosis, Focal                                               1 (2%)                                                          
      Inflammation, Focal, Subacute                                 1 (2%)       4 (8%)                                             
      Inflammation, Multifocal, Subacute                            1 (2%)                                                          
      Mineralization, Multifocal                       1 (2%)                                                                       
      Atrium, Thrombosis                                                         1 (2%)                                             
      Endothelium, Hyperplasia                                      1 (2%)                                                          
      Pericardium, Fibrosis                                                      1 (2%)                                             
      Pericardium, Inflammation, Subacute                                        1 (2%)                                             
      Valve, Bacterium                                              1 (2%)                                                          
      Valve, Thrombosis                                             1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (50)         (49)         (50)                                   
      Cyst                                             1 (2%)                                                                       
      Hyperplasia, Focal                               7 (14%)      4 (8%)       3 (6%)       5 (10%)                               
      Hypertrophy, Focal                                            2 (4%)       3 (6%)       2 (4%)                                
      Capsule, Accessory Adrenal Cortical Nodule       1 (2%)       1 (2%)       1 (2%)       1 (2%)                                
      Spindle Cell, Hyperplasia, Focal                 1 (2%)       3 (6%)       1 (2%)       2 (4%)                                
   Adrenal Gland, Medulla                             (50)         (50)         (48)         (50)                                   
      Hematopoietic Cell Proliferation                                           1 (2%)                                             
      Hyperplasia, Focal                               5 (10%)      4 (8%)       7 (15%)      6 (12%)                               
   Islets, Pancreatic                                 (50)         (48)         (49)         (49)                                   
      Hyperplasia                                     14 (28%)     21 (44%)     15 (31%)     12 (24%)                               
      Pigmentation, Hemosiderin                        1 (2%)                                                                       
   Parathyroid Gland                                  (43)         (43)         (47)         (44)                                   
      Cyst                                                          1 (2%)                                                          
   Pituitary Gland                                    (47)         (45)         (46)         (49)                                   
      Pars Distalis, Cyst                                           2 (4%)                    3 (6%)                                
      Pars Distalis, Hyperplasia, Focal                1 (2%)       2 (4%)       2 (4%)                                             
      Pars Nervosa, Fibrosis                                                     1 (2%)                                             
   Thyroid Gland                                      (49)         (50)         (48)         (50)                                   
      Ultimobranchial Cyst                                                       1 (2%)       2 (4%)                                
      Follicle, Cyst                                   6 (12%)      1 (2%)       2 (4%)       3 (6%)                                
      Follicle, Degeneration, Cystic                  17 (35%)     15 (30%)     14 (29%)     14 (28%)                               
      Follicular Cell, Hyperplasia, Cystic, Focal                                2 (4%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   10                                                              
NTP Experiment-Test: 05005-08         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                              FURFURAL                                         Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 06:46:15  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          VEHICLE      50.          100.         175.                                      
                                                   CONTROL      MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Coagulating Gland                                  (4)          (5)          (2)          (2)                                    
      Dilatation                                       4 (100%)     5 (100%)     2 (100%)     1 (50%)                               
      Inflammation, Chronic                                                      1 (50%)                                            
      Inflammation, Subacute                                        1 (20%)                                                         
   Epididymis                                         (50)         (50)         (49)         (50)                                   
      Fibrosis, Focal                                                                         1 (2%)                                
      Infiltration Cellular, Multifocal, Lymphocyte                 1 (2%)       3 (6%)                                             
      Pigmentation, Focal, Cholesterol                                                        1 (2%)                                
   Preputial Gland                                    (9)          (10)         (14)         (8)                                    
      Hyperplasia                                                   1 (10%)                                                         
      Inflammation, Subacute                           7 (78%)      8 (80%)     12 (86%)      6 (75%)                               
      Duct, Cyst                                       3 (33%)      8 (80%)     12 (86%)      5 (63%)                               
      Duct, Hyperplasia                                                          1 (7%)                                             
   Prostate                                           (50)         (50)         (48)         (49)                                   
      Infiltration Cellular, Multifocal, Lymphocyte                 2 (4%)       1 (2%)                                             
      Inflammation, Subacute                           1 (2%)                                 1 (2%)                                
   Seminal Vesicle                                    (50)         (50)         (48)         (50)                                   
      Atrophy                                                       1 (2%)                                                          
      Dilatation                                       7 (14%)      7 (14%)      6 (13%)      3 (6%)                                
      Inflammation, Subacute                                        1 (2%)       1 (2%)       1 (2%)                                
      Necrosis, Focal                                                                         1 (2%)                                
   Testes                                             (50)         (50)         (49)         (50)                                   
      Capsule, Mineralization                                                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Blood                                              (1)          (2)          (4)          (1)                                    
      Leukocytosis                                     1 (100%)     2 (100%)     3 (75%)      1 (100%)                              
      Polychromasia                                                 2 (100%)     2 (50%)                                            
   Bone Marrow                                        (50)         (49)         (49)         (50)                                   
      Hyperplasia                                     10 (20%)      7 (14%)     10 (20%)      8 (16%)                               
      Necrosis                                                      1 (2%)                                                          
   Lymph Node                                         (50)         (50)         (49)         (50)                                   
      Hyperplasia, Lymphoid                                                      1 (2%)                                             
      Axillary, Hyperplasia, Lymphoid                               1 (2%)                                                          
      Iliac, Hyperplasia, Lymphoid                                               1 (2%)                                             
      Inguinal, Hyperplasia, Lymphoid                  2 (4%)       4 (8%)       2 (4%)                                             
      Inguinal, Inflammation, Subacute                              1 (2%)                                                          
      Inguinal, Pigmentation, Hemosiderin              1 (2%)                                                                       
      Mediastinal, Angiectasis                                                                2 (4%)                                
      Mediastinal, Hyperplasia, Lymphoid               1 (2%)                    1 (2%)                                             
      Renal, Angiectasis                                            1 (2%)                                                          
   Lymph Node, Mandibular                             (44)         (46)         (47)         (48)                                   
      Ectasia                                                       1 (2%)                                                          
      Hyperplasia, Lymphoid                            3 (7%)       1 (2%)                    3 (6%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   11                                                              
NTP Experiment-Test: 05005-08         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                              FURFURAL                                         Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 06:46:15  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          VEHICLE      50.          100.         175.                                      
                                                   CONTROL      MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Necrosis                                                                                3 (6%)                                
   Lymph Node, Mesenteric                             (49)         (45)         (49)         (50)                                   
      Angiectasis                                     15 (31%)     18 (40%)     17 (35%)     12 (24%)                               
      Hematopoietic Cell Proliferation                              2 (4%)       3 (6%)       3 (6%)                                
      Hyperplasia, Lymphoid                           10 (20%)      8 (18%)      7 (14%)     10 (20%)                               
      Inflammation, Chronic                                                                   1 (2%)                                
      Necrosis                                                                                1 (2%)                                
   Spleen                                             (50)         (50)         (48)         (49)                                   
      Atrophy                                                       2 (4%)                    3 (6%)                                
      Developmental Malformation                                                 1 (2%)                                             
      Hematopoietic Cell Proliferation                10 (20%)     19 (38%)     18 (38%)     12 (24%)                               
      Hyperplasia, Lymphoid                           16 (32%)     14 (28%)     13 (27%)     16 (33%)                               
      Necrosis                                                                                3 (6%)                                
   Thymus                                             (47)         (42)         (44)         (45)                                   
      Atrophy                                                       7 (17%)      1 (2%)                                             
      Cyst                                             7 (15%)      2 (5%)       8 (18%)      2 (4%)                                
      Necrosis                                                                                4 (9%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (50)         (50)         (49)         (50)                                   
      Alopecia, Focal                                                            3 (6%)       1 (2%)                                
      Fibrosis, Multifocal                                                       1 (2%)                                             
      Ulcer, Focal                                     1 (2%)                    2 (4%)                                             
      Epidermis, Hyperplasia, Focal                    5 (10%)      5 (10%)      8 (16%)      1 (2%)                                
      Epidermis, Inflammation, Acute, Focal,                                                                                        
          Suppurative                                  1 (2%)                    2 (4%)                                             
      Prepuce, Developmental Malformation                           2 (4%)                                                          
      Sebaceous Gland, Hyperplasia, Focal                           1 (2%)       1 (2%)       1 (2%)                                
      Subcutaneous Tissue, Cyst                                     2 (4%)                                                          
      Subcutaneous Tissue, Edema, Focal                1 (2%)                    1 (2%)                                             
      Subcutaneous Tissue, Fibrosis, Focal            12 (24%)      5 (10%)      8 (16%)     10 (20%)                               
      Subcutaneous Tissue, Hemorrhage, Focal           1 (2%)                                                                       
      Subcutaneous Tissue, Inflammation, Acute,                                                                                     
           Focal, Suppurative                          1 (2%)       1 (2%)                                                          
      Subcutaneous Tissue, Inflammation, Focal,                                                                                     
           Subacute                                                 3 (6%)                    3 (6%)                                
      Subcutaneous Tissue, Inflammation,                                                                                            
          Granulomatous, Multifocal                    1 (2%)                                                                       
      Subcutaneous Tissue, Metaplasia, Focal,                                                                                       
          Osseous                                      1 (2%)       1 (2%)                    1 (2%)                                
      Subcutaneous Tissue, Mineralization, Focal                                              1 (2%)                                
      Subcutaneous Tissue, Necrosis, Focal                                                    1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   12                                                              
NTP Experiment-Test: 05005-08         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                              FURFURAL                                         Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 06:46:15  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          VEHICLE      50.          100.         175.                                      
                                                   CONTROL      MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (49)         (49)         (50)                                   
      Arthrosis, Chronic                               6 (12%)      1 (2%)       2 (4%)       1 (2%)                                
      Fracture                                                                   1 (2%)                                             
   Skeletal Muscle                                    (1)          (3)          (2)          (1)                                    
      Abdominal, Inflammation, Suppurative             1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (49)         (50)         (49)         (50)                                   
      Degeneration, Focal                                                        1 (2%)                                             
      Edema, Focal                                                               1 (2%)                                             
      Hemorrhage                                                                 1 (2%)                                             
      Hydrocephalus                                                              1 (2%)                                             
      Meninges, Infiltration Cellular, Multifocal,                                                                                  
           Lymphocyte                                                            1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (49)         (50)                                   
      Congestion                                       2 (4%)       1 (2%)       1 (2%)       2 (4%)                                
      Foreign Body                                                  1 (2%)                    1 (2%)                                
      Hemorrhage, Focal                                1 (2%)                                                                       
      Hemorrhage, Multifocal                                                                  1 (2%)                                
      Infiltration Cellular, Multifocal, Histiocyte    4 (8%)       4 (8%)       4 (8%)       6 (12%)                               
      Alveolar Epithelium, Hyperplasia, Focal                                    1 (2%)                                             
      Alveolar Epithelium, Hyperplasia, Multifocal                  1 (2%)                                                          
      Mediastinum, Foreign Body                                     2 (4%)                                                          
      Mediastinum, Inflammation, Chronic                            1 (2%)                                                          
      Mediastinum, Inflammation, Focal, Subacute                                 1 (2%)                                             
   Nose                                               (49)         (50)         (49)         (50)                                   
      Inflammation, Acute, Suppurative                              1 (2%)                    4 (8%)                                
      Nasolacrimal Duct, Cyst                                                    1 (2%)                                             
      Nasolacrimal Duct, Exudate                                                 1 (2%)                                             
      Nasolacrimal Duct, Inflammation, Acute,                                                                                       
          Suppurative                                  1 (2%)                                                                       
      Nasolacrimal Duct, Inflammation, Subacute        1 (2%)       2 (4%)       2 (4%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   13                                                              
NTP Experiment-Test: 05005-08         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                              FURFURAL                                         Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 06:46:15  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          VEHICLE      50.          100.         175.                                      
                                                   CONTROL      MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (49)         (50)                                   
      Bacterium, Multifocal                                                                   1 (2%)                                
      Fibrosis, Focal                                  2 (4%)       4 (8%)       3 (6%)       2 (4%)                                
      Infiltration Cellular, Multifocal, Lymphocyte   25 (50%)     19 (38%)     25 (51%)     23 (46%)                               
      Inflammation, Acute, Multifocal, Suppurative                  1 (2%)                    1 (2%)                                
      Metaplasia, Focal, Osseous                       1 (2%)       1 (2%)                    1 (2%)                                
      Nephropathy, Chronic                            37 (74%)     39 (78%)     37 (76%)     36 (72%)                               
      Renal Tubule, Dilatation, Multifocal                                       1 (2%)                                             
      Renal Tubule, Hyperplasia                                     1 (2%)                                                          
      Renal Tubule, Mineralization, Multifocal         1 (2%)                                 1 (2%)                                
      Renal Tubule, Necrosis, Multifocal                            1 (2%)       1 (2%)                                             
   Urinary Bladder                                    (49)         (50)         (49)         (49)                                   
      Inflammation, Subacute                                        1 (2%)                                                          
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   14                                                              
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                             ----------              END OF REPORT             ----------                                           
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