National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/3096

TR 382 Mouse Pathology Tables


                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                              FURFURAL


NTP Experiment-Test: 05005-08                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 09/03/94
Route: GAVAGE                                                                                                     Time: 06:46:19




       Facility:  Southern Research Institute

       Chemical CAS #:  98-01-1

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05005-08  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                              FURFURAL                                         Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 06:46:19  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        VEHICLE      50.          100.         175.                                      
                                                   CONTROL      MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Moribund                                           8           11            9            7                                     
    Dead                                               8            8           11           11                                     
    Dosing Accident                                    1                                                                            
    Natural Death                                                   1            1                                                  
    Accident                                                        2                                                               
  Survivors                                                                                                                         
    Terminal Sacrifice                                32           28           29           32                                     
    Terminal Sacrifice                                 1                                                                            
  Animals Examined Microscopically                    50           50           50           50                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (46)         (46)         (48)         (43)                                   
   Intestine Small, Duodenum                          (46)         (48)         (45)         (49)                                   
      Polyp Adenomatous                                             1 (2%)       1 (2%)                                             
   Intestine Small, Ileum                             (49)         (47)         (48)         (49)                                   
   Intestine Small, Jejunum                           (48)         (48)         (46)         (50)                                   
   Liver                                              (50)         (50)         (50)         (50)                                   
      Carcinoma, Metastatic, Islets, Pancreatic                                  1 (2%)                                             
      Hemangiosarcoma                                  1 (2%)                                                                       
      Hepatocellular Carcinoma                         4 (8%)                    2 (4%)       4 (8%)                                
      Hepatocellular Adenoma                           1 (2%)       3 (6%)       5 (10%)      8 (16%)                               
      Histiocytic Sarcoma, Metastatic                               1 (2%)                                                          
   Mesentery                                          (6)          (10)         (7)          (11)                                   
      Hemangioma                                                    1 (10%)                                                         
   Pancreas                                           (50)         (50)         (48)         (50)                                   
      Histiocytic Sarcoma                                           1 (2%)                                                          
   Salivary Glands                                    (50)         (50)         (50)         (50)                                   
   Stomach, Forestomach                               (50)         (50)         (50)         (50)                                   
      Squamous Cell Papilloma                          1 (2%)                    1 (2%)       6 (12%)                               
   Stomach, Glandular                                 (50)         (50)         (50)         (50)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)         (50)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   2                                                               
NTP Experiment-Test: 05005-08  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                              FURFURAL                                         Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 06:46:19  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        VEHICLE      50.          100.         175.                                      
                                                   CONTROL      MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (50)         (50)         (50)                                   
      Adenoma                                          1 (2%)                                                                       
   Adrenal Gland, Medulla                             (50)         (50)         (50)         (50)                                   
      Pheochromocytoma Benign                          1 (2%)                                                                       
   Islets, Pancreatic                                 (50)         (50)         (48)         (50)                                   
      Adenoma                                                       1 (2%)                    1 (2%)                                
      Carcinoma                                                                  1 (2%)                                             
   Pituitary Gland                                    (46)         (49)         (49)         (49)                                   
      Pars Distalis, Adenoma                           7 (15%)      3 (6%)       4 (8%)       9 (18%)                               
      Pars Distalis, Fibrosarcoma, Extension,                                                                                       
          Metastatic, Skin                                                       1 (2%)                                             
   Thyroid Gland                                      (50)         (50)         (49)         (50)                                   
      Follicular Cell, Adenoma                                                   1 (2%)       2 (4%)                                
      Follicular Cell, Adenoma, Cystic                 2 (4%)       1 (2%)       3 (6%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (48)         (49)         (50)         (50)                                   
      Carcinoma                                        1 (2%)                                                                       
      Cystadenoma, Papillary                           2 (4%)       1 (2%)                    1 (2%)                                
      Mixed Tumor Benign                                            1 (2%)                                                          
      Teratoma                                                                                1 (2%)                                
      Yolk Sac Carcinoma                                            1 (2%)                                                          
   Uterus                                             (50)         (50)         (50)         (50)                                   
      Leiomyoma                                        1 (2%)                                                                       
      Polyp Stromal                                    1 (2%)                    1 (2%)                                             
      Sarcoma Stromal                                               1 (2%)                                                          
      Cervix, Histiocytic Sarcoma                                   1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (49)         (49)         (50)                                   
      Hemangiosarcoma                                  1 (2%)       1 (2%)                                                          
   Lymph Node                                         (50)         (50)         (50)         (50)                                   
      Pancreatic, Histiocytic Sarcoma                               1 (2%)                                                          
   Lymph Node, Mandibular                             (47)         (47)         (49)         (48)                                   
      Carcinoma, Metastatic, Harderian Gland                        1 (2%)                                                          
   Lymph Node, Mesenteric                             (48)         (46)         (49)         (48)                                   
   Spleen                                             (50)         (50)         (50)         (50)                                   
                                                             Page   3                                                               
NTP Experiment-Test: 05005-08  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                              FURFURAL                                         Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 06:46:19  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        VEHICLE      50.          100.         175.                                      
                                                   CONTROL      MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - cont                                                                                                         
      Hemangiosarcoma                                  1 (2%)                                 1 (2%)                                
      Hemangiosarcoma, Multiple                                     1 (2%)                                                          
   Thymus                                             (49)         (47)         (44)         (46)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (50)         (50)         (48)                                   
      Adenoacanthoma                                   1 (2%)                                                                       
      Adenocarcinoma                                   1 (2%)                    1 (2%)       1 (2%)                                
      Adenocarcinoma, Multiple, Two                                 1 (2%)                                                          
   Skin                                               (50)         (50)         (50)         (50)                                   
      Squamous Cell Carcinoma                                                                 1 (2%)                                
      Squamous Cell Papilloma                          1 (2%)                                                                       
      Subcutaneous Tissue, Fibrosarcoma                2 (4%)                    1 (2%)       2 (4%)                                
      Subcutaneous Tissue, Hemangioma                                            1 (2%)                                             
      Subcutaneous Tissue, Hemangiosarcoma             1 (2%)                                 1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)                                   
      Carcinoma, Metastatic, Harderian Gland                        1 (2%)                                                          
      Cranium, Fibrosarcoma, Extension, Metastatic,                                                                                 
           Skin                                                                  1 (2%)                                             
   Skeletal Muscle                                    (1)          (3)          (1)                                                 
      Carcinoma, Metastatic, Harderian Gland                        1 (33%)                                                         
      Hemangiosarcoma                                               1 (33%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)                                   
      Meninges, Fibrosarcoma, Extension,                                                                                            
          Metastatic, Skin                                                       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)                                   
      Alveolar/Bronchiolar Adenoma                     3 (6%)       1 (2%)       1 (2%)       3 (6%)                                
      Alveolar/Bronchiolar Carcinoma                   1 (2%)       1 (2%)                                                          
      Alveolar/Bronchiolar Carcinoma, Multiple, Two    1 (2%)                                                                       
      Carcinoma, Multiple, Metastatic, Four,                                                                                        
          Harderian Gland                                           1 (2%)                                                          
   Nose                                               (50)         (50)         (50)         (50)                                   
      Lumen, Carcinoma, Metastatic, Harderian Gland                 1 (2%)                                                          
                                                             Page   4                                                               
NTP Experiment-Test: 05005-08  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                              FURFURAL                                         Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 06:46:19  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        VEHICLE      50.          100.         175.                                      
                                                   CONTROL      MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - cont                                                                                                           
   Trachea                                            (50)         (50)         (49)         (50)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                                 (1)          (1)          (2)                                    
      Adenoma                                                                                 2 (100%)                              
      Carcinoma                                                     1 (100%)                                                        
      Fibrosarcoma, Extension, Metastatic, Skin                                  1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (50)                                   
      Cortex, Adenoma                                               1 (2%)                                                          
   Urinary Bladder                                    (50)         (50)         (50)         (50)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)        *(50)                                   
      Histiocytic Sarcoma                                           2 (4%)                                                          
      Lymphoma Malignant Histiocytic                   1 (2%)       1 (2%)                                                          
      Lymphoma Malignant Lymphocytic                                2 (4%)       2 (4%)                                             
      Lymphoma Malignant Mixed                         8 (16%)     10 (20%)      7 (14%)      8 (16%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   5                                                               
NTP Experiment-Test: 05005-08  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                              FURFURAL                                         Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 06:46:19  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        VEHICLE      50.          100.         175.                                      
                                                   CONTROL      MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            33          26          24          31                                       
     Total Primary Neoplasms                           45          37          32          51                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 16          14          16          23                                       
     Total Benign Neoplasms                            21          14          18          33                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              22          20          12          16                                       
     Total Malignant Neoplasms                         24          23          14          18                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms                          2           2                                                   
     Total Metastatic Neoplasm                                      6           5                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   6                                                               
NTP Experiment-Test: 05005-08  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                              FURFURAL                                         Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 06:46:19  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          VEHICLE      50.          100.         175.                                      
                                                   CONTROL      MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Dead                                               9           12           13            8                                     
    Moribund                                           6            8           12            8                                     
    Natural Death                                                                             1                                     
    Accident                                                                                  1                                     
    Accidently Killed                                                                         5                                     
    Dosing Accident                                                 2                                                               
  Survivors                                                                                                                         
    Terminal Sacrifice                                35           28           24           27                                     
  Missing                                                                        1                                                  
  Animals Examined Microscopically                    50           50           49           50                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (46)         (44)         (43)         (42)                                   
   Intestine Large, Cecum                             (49)         (47)         (49)         (46)                                   
   Intestine Large, Rectum                            (48)         (49)         (49)         (48)                                   
   Intestine Small, Ileum                             (45)         (47)         (48)         (47)                                   
   Intestine Small, Jejunum                           (47)         (46)         (47)         (45)                                   
      Polyp Adenomatous                                                          1 (2%)                                             
   Liver                                              (50)         (50)         (49)         (50)                                   
      Carcinoma, Metastatic                                                                   1 (2%)                                
      Fibrosarcoma, Extension, Metastatic,                                                                                          
          Mesentery                                                              1 (2%)                                             
      Hemangioma                                       1 (2%)                                                                       
      Hemangiosarcoma                                  2 (4%)       4 (8%)       2 (4%)                                             
      Hemangiosarcoma, Multiple, Two                                             1 (2%)                                             
      Hemangiosarcoma, Multiple, Four                               1 (2%)                                                          
      Hepatoblastoma                                   1 (2%)                    1 (2%)       1 (2%)                                
      Hepatocellular Carcinoma                         6 (12%)     12 (24%)      5 (10%)     15 (30%)                               
      Hepatocellular Carcinoma, Multiple                                                      1 (2%)                                
      Hepatocellular Carcinoma, Multiple, Two          1 (2%)                    1 (2%)       4 (8%)                                
      Hepatocellular Carcinoma, Multiple, Three                                               1 (2%)                                
      Hepatocellular Adenoma                           9 (18%)     12 (24%)      7 (14%)     14 (28%)                               
      Hepatocellular Adenoma, Multiple, Two                                      4 (8%)       2 (4%)                                
      Hepatocellular Adenoma, Multiple, Three                       1 (2%)                    2 (4%)                                
      Hepatocellular Adenoma, Two                                                             1 (2%)                                
      Squamous Cell Carcinoma, Metastatic, Stomach     1 (2%)                                                                       
   Mesentery                                          (4)          (3)          (5)          (5)                                    
      Carcinoma, Metastatic                                                                   1 (20%)                               
      Fibrosarcoma, Extension, Metastatic, Skin                                  1 (20%)                                            
      Fibrosarcoma, Multiple, Greater Than Five                                  1 (20%)                                            
                                                             Page   7                                                               
NTP Experiment-Test: 05005-08  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                              FURFURAL                                         Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 06:46:19  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          VEHICLE      50.          100.         175.                                      
                                                   CONTROL      MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - cont                                                                                                            
   Pancreas                                           (50)         (50)         (49)         (49)                                   
      Fibrosarcoma, Extension, Metastatic,                                                                                          
          Mesentery                                                              1 (2%)                                             
   Salivary Glands                                    (50)         (50)         (49)         (50)                                   
      Fibrosarcoma, Extension, Metastatic, Skin        1 (2%)       1 (2%)       2 (4%)                                             
   Stomach, Forestomach                               (50)         (49)         (49)         (49)                                   
      Adenocarcinoma                                                                          1 (2%)                                
      Fibrosarcoma, Metastatic, Mesentery                                        1 (2%)                                             
      Squamous Cell Carcinoma                          1 (2%)                                                                       
      Squamous Cell Papilloma                          1 (2%)                                 1 (2%)                                
   Stomach, Glandular                                 (50)         (49)         (49)         (49)                                   
      Carcinoma, Metastatic, Seminal Vesicle                        1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (49)         (50)                                   
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                     1 (2%)                                                          
      Carcinoma, Metastatic                                                                   1 (2%)                                
      Hemangiosarcoma                                  1 (2%)                                                                       
      Sarcoma, Metastatic, Skeletal Muscle                                                    1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (50)         (49)         (50)                                   
      Capsule, Fibrosarcoma, Extension, Metastatic,                                                                                 
           Mesentery                                                             1 (2%)                                             
      Spindle Cell, Adenoma                                         1 (2%)                                                          
   Adrenal Gland, Medulla                             (50)         (50)         (48)         (50)                                   
      Pheochromocytoma Malignant                       1 (2%)                                                                       
      Pheochromocytoma Benign                          2 (4%)       4 (8%)       2 (4%)       1 (2%)                                
      Pheochromocytoma Benign, Multiple                             1 (2%)                                                          
   Islets, Pancreatic                                 (50)         (48)         (49)         (49)                                   
      Adenoma                                          1 (2%)                                                                       
   Pituitary Gland                                    (47)         (45)         (46)         (49)                                   
      Pars Distalis, Adenoma                                                                  2 (4%)                                
   Thyroid Gland                                      (49)         (50)         (48)         (50)                                   
      Follicular Cell, Adenoma                         1 (2%)                                 2 (4%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   8                                                               
NTP Experiment-Test: 05005-08  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                              FURFURAL                                         Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 06:46:19  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          VEHICLE      50.          100.         175.                                      
                                                   CONTROL      MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Coagulating Gland                                  (4)          (5)          (2)          (2)                                    
   Epididymis                                         (50)         (50)         (49)         (50)                                   
   Penis                                              (1)                                                                           
      Fibrosarcoma                                     1 (100%)                                                                     
   Preputial Gland                                    (9)          (10)         (14)         (8)                                    
      Squamous Cell Papilloma                                                    1 (7%)                                             
   Prostate                                           (50)         (50)         (48)         (49)                                   
   Seminal Vesicle                                    (50)         (50)         (48)         (50)                                   
      Carcinoma                                                     1 (2%)                                                          
      Fibrosarcoma, Extension, Metastatic,                                                                                          
          Mesentery                                                              1 (2%)                                             
   Testes                                             (50)         (50)         (49)         (50)                                   
      Interstitial Cell, Adenoma                       1 (2%)                    2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (49)         (49)         (50)                                   
      Hemangiosarcoma                                  1 (2%)       2 (4%)                    1 (2%)                                
   Lymph Node                                         (50)         (50)         (49)         (50)                                   
      Axillary, Histiocytic Sarcoma                                              1 (2%)                                             
      Iliac, Histiocytic Sarcoma                                                 1 (2%)                                             
      Inguinal, Histiocytic Sarcoma                                              1 (2%)                                             
      Inguinal, Squamous Cell Carcinoma,                                                                                            
          Metastatic, Skin                                                                    1 (2%)                                
      Mediastinal, Alveolar/Bronchiolar Carcinoma,                                                                                  
           Metastatic, Lung                                         1 (2%)                                                          
      Mediastinal, Carcinoma, Metastatic                                                      1 (2%)                                
      Mediastinal, Carcinoma, Metastatic, Seminal                                                                                   
          Vesicle                                                   1 (2%)                                                          
      Mediastinal, Fibrosarcoma, Metastatic,                                                                                        
          Mesentery                                                              1 (2%)                                             
      Pancreatic, Histiocytic Sarcoma                                            1 (2%)                                             
      Pancreatic, Squamous Cell Carcinoma,                                                                                          
          Metastatic, Stomach                          1 (2%)                                                                       
      Renal, Histiocytic Sarcoma                                                 1 (2%)                                             
   Lymph Node, Mandibular                             (44)         (46)         (47)         (48)                                   
      Histiocytic Sarcoma                                                        1 (2%)                                             
   Lymph Node, Mesenteric                             (49)         (45)         (49)         (50)                                   
      Fibrosarcoma, Metastatic, Spleen                 1 (2%)                                                                       
      Histiocytic Sarcoma                                                        1 (2%)                                             
   Spleen                                             (50)         (50)         (48)         (49)                                   
      Fibrosarcoma                                     1 (2%)                                                                       
      Hemangiosarcoma                                  2 (4%)       2 (4%)                                                          
   Thymus                                             (47)         (42)         (44)         (45)                                   
      Histiocytic Sarcoma                                                        1 (2%)                                             
                                                             Page   9                                                               
NTP Experiment-Test: 05005-08  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                              FURFURAL                                         Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 06:46:19  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          VEHICLE      50.          100.         175.                                      
                                                   CONTROL      MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - cont                                                                                                         
      Sarcoma, Metastatic, Skeletal Muscle                                                    1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (50)         (50)         (49)         (50)                                   
      Basal Cell Adenoma                                                         1 (2%)                                             
      Keratoacanthoma                                               1 (2%)                                                          
      Squamous Cell Carcinoma                          1 (2%)                                 2 (4%)                                
      Squamous Cell Papilloma                                       2 (4%)                                                          
      Subcutaneous Tissue, Fibroma                     3 (6%)       1 (2%)       2 (4%)       1 (2%)                                
      Subcutaneous Tissue, Fibrosarcoma                2 (4%)       6 (12%)     10 (20%)      2 (4%)                                
      Subcutaneous Tissue, Fibrosarcoma, Multiple      1 (2%)                                                                       
      Subcutaneous Tissue, Fibrous Histiocytoma                     1 (2%)                                                          
      Subcutaneous Tissue, Hemangioma                               1 (2%)                                                          
      Subcutaneous Tissue, Hemangiosarcoma             2 (4%)       1 (2%)       1 (2%)       1 (2%)                                
      Subcutaneous Tissue, Sarcoma                                               1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                    (1)          (3)          (2)          (1)                                    
      Alveolar/Bronchiolar Carcinoma, Multiple,                                                                                     
           Metastatic, Two, Lung                                    1 (33%)                                                         
      Fibrosarcoma, Extension, Metastatic,                                                                                          
          Mesentery                                                              1 (50%)                                            
      Fibrosarcoma, Extension, Metastatic, Skin                                  1 (50%)                                            
      Hemangiosarcoma                                               1 (33%)                                                         
      Sarcoma                                                                                 1 (100%)                              
      Abdominal, Carcinoma, Metastatic, Seminal                                                                                     
          Vesicle                                                   1 (33%)                                                         
      Diaphragm, Carcinoma, Metastatic, Seminal                                                                                     
          Vesicle                                                   1 (33%)                                                         
      Intercostal, Carcinoma, Metastatic, Seminal                                                                                   
          Vesicle                                                   1 (33%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (49)         (50)         (49)         (50)                                   
      Meningioma Malignant                                          1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page  10                                                               
NTP Experiment-Test: 05005-08  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                              FURFURAL                                         Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 06:46:19  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          VEHICLE      50.          100.         175.                                      
                                                   CONTROL      MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (49)         (50)                                   
      Alveolar/Bronchiolar Adenoma                     9 (18%)      3 (6%)       2 (4%)       8 (16%)                               
      Alveolar/Bronchiolar Carcinoma                   3 (6%)       4 (8%)       2 (4%)       6 (12%)                               
      Alveolar/Bronchiolar Carcinoma, Multiple,                                                                                     
           Greater Than Five                                        1 (2%)       1 (2%)                                             
      Carcinoma, Multiple, Metastatic, Greater                                                                                      
          Than Five                                                                           1 (2%)                                
      Carcinoma, Multiple, Metastatic, Greater                                                                                      
          Than Five, Seminal Vesicle                                1 (2%)                                                          
      Fibrosarcoma, Multiple, Metastatic, Greater                                                                                   
          Than Five, Skin                                                        1 (2%)                                             
      Fibrosarcoma, Metastatic                                                   1 (2%)                                             
      Hemangiosarcoma                                               1 (2%)                                                          
      Hepatocellular Carcinoma, Multiple,                                                                                           
          Metastatic, Two, Liver                                                              1 (2%)                                
      Hepatocellular Carcinoma, Multiple,                                                                                           
          Metastatic, Four, Liver                                   1 (2%)                                                          
      Hepatocellular Carcinoma, Multiple,                                                                                           
          Metastatic, Greater Than Five, Liver                      1 (2%)                    1 (2%)                                
      Hepatocellular Carcinoma, Metastatic, Liver                   2 (4%)                                                          
      Sarcoma, Metastatic, Skeletal Muscle                                                    1 (2%)                                
      Mediastinum, Carcinoma, Multiple, Metastatic,                                                                                 
           Greater Than Five, Seminal Vesicle                       1 (2%)                                                          
      Mediastinum, Fibrosarcoma, Metastatic,                                                                                        
          Mesentery                                                              1 (2%)                                             
   Nose                                               (49)         (50)         (49)         (50)                                   
      Polyp                                                                                   1 (2%)                                
   Trachea                                            (50)         (50)         (48)         (50)                                   
      Retinoblastoma, Metastatic                                                              1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                                 (2)          (2)          (1)                                    
      Adenoma                                                       2 (100%)     1 (50%)      1 (100%)                              
      Carcinoma                                                                  1 (50%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (49)         (50)                                   
      Carcinoma, Metastatic, Seminal Vesicle                        1 (2%)                                                          
      Cortex, Adenoma                                                            1 (2%)       1 (2%)                                
      Cortex, Carcinoma                                             1 (2%)                                                          
      Cortex, Carcinoma, Metastatic                                                           1 (2%)                                
   Urinary Bladder                                    (49)         (50)         (49)         (49)                                   
                                                             Page  11                                                               
NTP Experiment-Test: 05005-08  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                              FURFURAL                                         Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 06:46:19  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          VEHICLE      50.          100.         175.                                      
                                                   CONTROL      MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(49)        *(50)                                   
      Histiocytic Sarcoma                                                        1 (2%)                                             
      Lymphoma Malignant Histiocytic                                                          1 (2%)                                
      Lymphoma Malignant Lymphocytic                   2 (4%)                    2 (4%)       1 (2%)                                
      Lymphoma Malignant Mixed                         3 (6%)       2 (4%)       5 (10%)      2 (4%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  12                                                               
NTP Experiment-Test: 05005-08  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                              FURFURAL                                         Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 06:46:19  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          VEHICLE      50.          100.         175.                                      
                                                   CONTROL      MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            38          41          42          42                                       
     Total Primary Neoplasms                           60          70          59          77                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 24          24          20          30                                       
     Total Benign Neoplasms                            28          29          24          37                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              22          31          27          32                                       
     Total Malignant Neoplasms                         32          41          35          40                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              3           6           5           6                                       
     Total Metastatic Neoplasm                          4          16          15          13                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  13                                                               
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NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.