Share This:
https://ntp.niehs.nih.gov/go/3098

TR 382 Mouse Pathology Tables

NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Southern Research Inst                                     FURFURAL                                       DATE: 09/03/94       
EXPERIMENT: 05005 TEST: 08                                                                                     TIME: 06:59:36       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: NO1CP9565101          ROUTE: GAVAGE                                                                      NTP C#: 56177        
PATHOLOGIST: H. GILES                        S. EUSTIS                                                         CAS: 98-01-1         
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08    
LAB: Southern Research Inst                                     FURFURAL                                       DATE: 09/03/94      
EXPERIMENT: 05005 TEST: 08                                                                                     TIME: 06:59:36      
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                       
CONT: NO1CP9565101          ROUTE: GAVAGE                                                                      NTP C#: 56177       
PATHOLOGIST: H. GILES                        S. EUSTIS                                                         CAS: 98-01-1        
 
 
 
 
 
                                                    MICE(B6C3F1)
                                              ----------------------------
             FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
             IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
 
 
                                                    ----------------
 
                                                    Adrenal Gland
                                                    Bone Marrow
                                                    Brain
                                                    Epididymis
                                                    Gallbladder
                                                    Heart
                                                    Islets, Pancreatic
                                                    Kidney
                                                    Liver
                                                    Lung
                                                    Nose
                                                    Ovary
                                                    Pancreas
                                                    Parathyroid Gland
                                                    Pituitary Gland
                                                    Preputial Gland
                                                    Prostate
                                                    Salivary Glands
                                                    Spleen
                                                    Testes
                                                    Thymus
                                                    Thyroid Gland
                                                    Urinary Bladder
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Southern Research Inst                                     FURFURAL                                       DATE: 09/03/94       
EXPERIMENT: 05005 TEST: 08                                                                                     TIME: 06:59:36       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: NO1CP9565101          ROUTE: GAVAGE                                                                      NTP C#: 56177        
PATHOLOGIST: H. GILES                        S. EUSTIS                                                         CAS: 98-01-1         
 
 
 
 
 
                                     SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
                                            IN THE ANALYSIS OF THE STUDY OF FURFURAL
 
              ====================================================================================================
 
                                                           MALE MICE
                                                          -------------
                                 ORGAN                               MORPHOLOGY
                                -------                             ------------
 
                             Liver                         Hepatocellular Adenoma
                                                           Hepatocellular Carcinoma
                                                           Hepatocellular Carcinoma or Hepatoblastoma
                                                           Hepatocellular Carcinoma or Hepatocellular Adenoma
                                                           Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma
                             Pituitary Gland: Pars Distalis or Unspecified Site
                                                           Adenoma
                             Skin: Subcutaneous Tissue     Fibrosarcoma
                                                           Neurofibrosarcoma, Fibrosarcoma, Sarcoma,
                                                            Neurofibroma, or Fibroma
                                                           Neurofibrosarcoma, Fibrosarcoma, or Sarcoma
                             All Organs                    Benign Tumors
                                                           Malignant Tumors
                                                           Malignant and Benign Tumors
 
              ====================================================================================================
 
                                                           FEMALE MICE
                                                          -------------
                                 ORGAN                               MORPHOLOGY
                                -------                             ------------
 
                             Harderian Gland               Adenoma
                             Liver                         Hepatocellular Adenoma
                                                           Hepatocellular Carcinoma or Hepatocellular Adenoma
                                                           Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma
                             Stomach, Forestomach          Squamous Cell Carcinoma or Papilloma Squamous
                                                           Squamous Cell Papilloma
                             All Organs                    Malignant Tumors
 
              ====================================================================================================
         DATE: 09/03/94                     EXPERIMENT: 05005 TEST: 08                                                 PAGE   1
                                  STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- FURFURAL
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   VEHICLE      50.          100.         175.      |   VEHICLE      50.          100.         175.      |
|                       |   CONTROL      MG/KG        MG/KG        MG/KG     |   CONTROL      MG/KG        MG/KG        MG/KG     |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Pheochromocytoma Benign                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/50 (4%)    5/50 (10%)   2/48 (4%)    1/50 (2%)  |  1/50 (2%)    0/50 (0%)    0/50 (0%)    0/50 (0%)  |
|ADJUSTED (b)           |   5.7%        15.8%         8.3%         3.7%      |   3.0%         0.0%         0.0%         0.0%      |
|TERMINAL (d)           |  2/35 (6%)    2/28 (7%)    2/24 (8%)    1/27 (4%)  |  1/33 (3%)    0/28 (0%)    0/29 (0%)    0/32 (0%)  |
|FIRST INCIDENCE (DAYS) |   729 (T)      682          729 (T)      729 (T)   |   729 (T)      ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.322N     P=0.151      P=0.553      P=0.591N   |  P=0.254N     P=0.533N     P=0.526N     P=0.506N   |
|INCIDENTAL TUMOR       |  P=0.268N     P=0.278      P=0.553      P=0.591N   |  P=0.254N     P=0.533N     P=0.526N     P=0.506N   |
|LOGISTIC REGRESSION    |  P=0.282N     P=0.181      P=0.553      P=0.591N   |  P=0.254N     P=0.533N     P=0.526N     P=0.506N   |
|COCHRAN-ARMITAGE       |  P=0.228N                                          |  P=0.248N                                          |
|FISHER EXACT           |               P=0.218      P=0.676      P=0.500N   |               P=0.500N     P=0.500N     P=0.500N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Pheochromocytoma: Benign, Complex, Malignant, NOS                                                                           |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  3/50 (6%)    5/50 (10%)   2/48 (4%)    1/50 (2%)  |  1/50 (2%)    0/50 (0%)    0/50 (0%)    0/50 (0%)  |
|ADJUSTED (b)           |   8.6%        15.8%         8.3%         3.7%      |   3.0%         0.0%         0.0%         0.0%      |
|TERMINAL (d)           |  3/35 (9%)    2/28 (7%)    2/24 (8%)    1/27 (4%)  |  1/33 (3%)    0/28 (0%)    0/29 (0%)    0/32 (0%)  |
|FIRST INCIDENCE (DAYS) |   729 (T)      682          729 (T)      729 (T)   |   729 (T)      ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.214N     P=0.258      P=0.670N     P=0.401N   |  P=0.254N     P=0.533N     P=0.526N     P=0.506N   |
|INCIDENTAL TUMOR       |  P=0.171N     P=0.416      P=0.670N     P=0.401N   |  P=0.254N     P=0.533N     P=0.526N     P=0.506N   |
|LOGISTIC REGRESSION    |  P=0.179N     P=0.304      P=0.670N     P=0.401N   |  P=0.254N     P=0.533N     P=0.526N     P=0.506N   |
|COCHRAN-ARMITAGE       |  P=0.136N                                          |  P=0.248N                                          |
|FISHER EXACT           |               P=0.357      P=0.520N     P=0.309N   |               P=0.500N     P=0.500N     P=0.500N   |
|=================================================================================================================================|
 
         DATE: 09/03/94                     EXPERIMENT: 05005 TEST: 08                                                 PAGE   2
                                  STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- FURFURAL
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   VEHICLE      50.          100.         175.      |   VEHICLE      50.          100.         175.      |
|                       |   CONTROL      MG/KG        MG/KG        MG/KG     |   CONTROL      MG/KG        MG/KG        MG/KG     |
|=================================================================================================================================|
|                                                                                                                                 |
|Bone Marrow                                                                                                                      |
|     Hemangiosarcoma                                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/50 (2%)    2/49 (4%)    0/49 (0%)    1/50 (2%)  |  1/50 (2%)    1/49 (2%)    0/49 (0%)    0/50 (0%)  |
|ADJUSTED (b)           |   2.7%         6.7%         0.0%         3.2%      |   3.0%         2.6%         0.0%         0.0%      |
|TERMINAL (d)           |  0/35 (0%)    0/28 (0%)    0/24 (0%)    0/27 (0%)  |  1/33 (3%)    0/27 (0%)    0/29 (0%)    0/32 (0%)  |
|FIRST INCIDENCE (DAYS) |   703          697          ---          696       |   729 (T)      630          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.514N     P=0.423      P=0.563N     P=0.717    |  P=0.212N     P=0.732      P=0.526N     P=0.506N   |
|INCIDENTAL TUMOR       |  P=0.368N     P=0.746      P=0.383N     P=0.659N   |  P=0.161N     P=0.680      P=0.526N     P=0.506N   |
|LOGISTIC REGRESSION    |  P=0.491N     P=0.480      P=0.520N     P=0.741    |  P=0.204N     P=0.752      P=0.526N     P=0.506N   |
|COCHRAN-ARMITAGE       |  P=0.458N                                          |  P=0.204N                                          |
|FISHER EXACT           |               P=0.492      P=0.505N     P=0.753N   |               P=0.747      P=0.505N     P=0.500N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Harderian Gland                                                                                                                  |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    2/50 (4%)    1/49 (2%)    1/50 (2%)  |  0/50 (0%)    0/50 (0%)    0/50 (0%)    2/50 (4%)  |
|ADJUSTED (b)           |   0.0%         7.1%         3.3%         3.3%      |   0.0%         0.0%         0.0%         5.6%      |
|TERMINAL (d)           |  0/35 (0%)    2/28 (7%)    0/24 (0%)    0/27 (0%)  |  0/33 (0%)    0/28 (0%)    0/29 (0%)    1/32 (3%)  |
|FIRST INCIDENCE (DAYS) |   ---          729 (T)      688          724       |   ---          ---          ---          633       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.402      P=0.190      P=0.458      P=0.469    |  P=0.054        (e)          (e)        P=0.236    |
|INCIDENTAL TUMOR       |  P=0.459      P=0.190      P=0.617      P=0.594    |  P=0.089        (e)          (e)        P=0.299    |
|LOGISTIC REGRESSION    |  P=0.419      P=0.190      P=0.489      P=0.469    |  P=0.051        (e)          (e)        P=0.238    |
|COCHRAN-ARMITAGE       |  P=0.460                                           |  P=0.050 *                                         |
|FISHER EXACT           |               P=0.247      P=0.495      P=0.500    |                 (e)          (e)        P=0.247    |
|=================================================================================================================================|
 
         DATE: 09/03/94                     EXPERIMENT: 05005 TEST: 08                                                 PAGE   3
                                  STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- FURFURAL
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   VEHICLE      50.          100.         175.      |   VEHICLE      50.          100.         175.      |
|                       |   CONTROL      MG/KG        MG/KG        MG/KG     |   CONTROL      MG/KG        MG/KG        MG/KG     |
|=================================================================================================================================|
|                                                                                                                                 |
|Harderian Gland                                                                                                                  |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    2/50 (4%)    2/49 (4%)    1/50 (2%)  |  0/50 (0%)    1/50 (2%)    0/50 (0%)    2/50 (4%)  |
|ADJUSTED (b)           |   0.0%         7.1%         7.4%         3.3%      |   0.0%         3.1%         0.0%         5.6%      |
|TERMINAL (d)           |  0/35 (0%)    2/28 (7%)    1/24 (4%)    0/27 (0%)  |  0/33 (0%)    0/28 (0%)    0/29 (0%)    1/32 (3%)  |
|FIRST INCIDENCE (DAYS) |   ---          729 (T)      688          724       |   ---          704          ---          633       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.346      P=0.190      P=0.178      P=0.469    |  P=0.147      P=0.494        (e)        P=0.236    |
|INCIDENTAL TUMOR       |  P=0.392      P=0.190      P=0.256      P=0.594    |  P=0.173      P=0.594        (e)        P=0.299    |
|LOGISTIC REGRESSION    |  P=0.365      P=0.190      P=0.208      P=0.469    |  P=0.146      P=0.488        (e)        P=0.238    |
|COCHRAN-ARMITAGE       |  P=0.412                                           |  P=0.143                                           |
|FISHER EXACT           |               P=0.247      P=0.242      P=0.500    |               P=0.500        (e)        P=0.247    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hemangiosarcoma                                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/50 (4%)    5/50 (10%)   3/49 (6%)    0/50 (0%)  |  1/50 (2%)    0/50 (0%)    0/50 (0%)    0/50 (0%)  |
|ADJUSTED (b)           |   5.5%        14.5%        10.7%         0.0%      |   2.8%         0.0%         0.0%         0.0%      |
|TERMINAL (d)           |  1/35 (3%)    1/28 (4%)    2/24 (8%)    0/27 (0%)  |  0/33 (0%)    0/28 (0%)    0/29 (0%)    0/32 (0%)  |
|FIRST INCIDENCE (DAYS) |   703          491          617          ---       |   662          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.197N     P=0.164      P=0.367      P=0.293N   |  P=0.255N     P=0.511N     P=0.511N     P=0.511N   |
|INCIDENTAL TUMOR       |  P=0.114N     P=0.338      P=0.550      P=0.214N   |  P=0.263N     P=0.406N     P=0.464N     P=0.545N   |
|LOGISTIC REGRESSION    |  P=0.146N     P=0.209      P=0.458      P=0.266N   |  P=0.248N     P=0.501N     P=0.500N     P=0.501N   |
|COCHRAN-ARMITAGE       |  P=0.130N                                          |  P=0.248N                                          |
|FISHER EXACT           |               P=0.218      P=0.490      P=0.247N   |               P=0.500N     P=0.500N     P=0.500N   |
|=================================================================================================================================|
 
         DATE: 09/03/94                     EXPERIMENT: 05005 TEST: 08                                                 PAGE   4
                                  STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- FURFURAL
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   VEHICLE      50.          100.         175.      |   VEHICLE      50.          100.         175.      |
|                       |   CONTROL      MG/KG        MG/KG        MG/KG     |   CONTROL      MG/KG        MG/KG        MG/KG     |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Adenoma                                                                                                      |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  9/50 (18%)  13/50 (26%)  11/49 (22%)  19/50 (38%) |  1/50 (2%)    3/50 (6%)    5/50 (10%)   8/50 (16%) |
|ADJUSTED (b)           |  24.7%        38.8%        36.4%        56.7%      |   3.0%        10.7%        14.9%        22.8%      |
|TERMINAL (d)           |  8/35 (23%)   9/28 (32%)   6/24 (25%)  13/27 (48%) |  1/33 (3%)    3/28 (11%)   3/29 (10%)   6/32 (19%) |
|FIRST INCIDENCE (DAYS) |   611          491          571          563       |   729 (T)      729 (T)      493          615       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.004 **   P=0.116      P=0.153      P=0.004 ** |  P=0.008 **   P=0.247      P=0.087      P=0.017 *  |
|INCIDENTAL TUMOR       |  P=0.008 **   P=0.153      P=0.358      P=0.010 ** |  P=0.009 **   P=0.247      P=0.108      P=0.025 *  |
|LOGISTIC REGRESSION    |  P=0.008 **   P=0.201      P=0.292      P=0.008 ** |  P=0.007 **   P=0.247      P=0.100      P=0.017 *  |
|COCHRAN-ARMITAGE       |  P=0.021 *                                         |  P=0.007 **                                        |
|FISHER EXACT           |               P=0.235      P=0.382      P=0.022 *  |               P=0.309      P=0.102      P=0.015 *  |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma                                                                                                    |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  7/50 (14%)  12/50 (24%)   6/49 (12%)  21/50 (42%) |  4/50 (8%)    0/50 (0%)    2/50 (4%)    4/50 (8%)  |
|ADJUSTED (b)           |  17.4%        31.5%        18.2%        52.7%      |  12.1%         0.0%         6.1%        11.4%      |
|TERMINAL (d)           |  4/35 (11%)   5/28 (18%)   2/24 (8%)    9/27 (33%) |  4/33 (12%)   0/28 (0%)    1/29 (3%)    3/32 (9%)  |
|FIRST INCIDENCE (DAYS) |   456          433          620          456       |   729 (T)      ---          611          549       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.001 **   P=0.107      P=0.562      P<0.001 ** |  P=0.403      P=0.085N     P=0.398N     P=0.632    |
|INCIDENTAL TUMOR       |  P=0.001 **   P=0.166      P=0.274N     P=0.002 ** |  P=0.477      P=0.085N     P=0.388N     P=0.620N   |
|LOGISTIC REGRESSION    |  P=0.001 **   P=0.157      P=0.297N     P=0.001 ** |  P=0.402      P=0.085N     P=0.366N     P=0.640    |
|COCHRAN-ARMITAGE       |  P=0.002 **                                        |  P=0.400                                           |
|FISHER EXACT           |               P=0.154      P=0.516N     P=0.002 ** |               P=0.059N     P=0.339N     P=0.643N   |
|=================================================================================================================================|
 
         DATE: 09/03/94                     EXPERIMENT: 05005 TEST: 08                                                 PAGE   5
                                  STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- FURFURAL
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   VEHICLE      50.          100.         175.      |   VEHICLE      50.          100.         175.      |
|                       |   CONTROL      MG/KG        MG/KG        MG/KG     |   CONTROL      MG/KG        MG/KG        MG/KG     |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma or Hepatoblastoma                                                                                  |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  7/50 (14%)  12/50 (24%)   6/49 (12%)  21/50 (42%) |  4/50 (8%)    0/50 (0%)    2/50 (4%)    4/50 (8%)  |
|ADJUSTED (b)           |  17.4%        31.5%        18.2%        52.7%      |  12.1%         0.0%         6.1%        11.4%      |
|TERMINAL (d)           |  4/35 (11%)   5/28 (18%)   2/24 (8%)    9/27 (33%) |  4/33 (12%)   0/28 (0%)    1/29 (3%)    3/32 (9%)  |
|FIRST INCIDENCE (DAYS) |   456          433          620          456       |   729 (T)      ---          611          549       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.001 **   P=0.107      P=0.562      P<0.001 ** |  P=0.403      P=0.085N     P=0.398N     P=0.632    |
|INCIDENTAL TUMOR       |  P=0.001 **   P=0.166      P=0.274N     P=0.002 ** |  P=0.477      P=0.085N     P=0.388N     P=0.620N   |
|LOGISTIC REGRESSION    |  P=0.001 **   P=0.157      P=0.297N     P=0.001 ** |  P=0.402      P=0.085N     P=0.366N     P=0.640    |
|COCHRAN-ARMITAGE       |  P=0.002 **                                        |  P=0.400                                           |
|FISHER EXACT           |               P=0.154      P=0.516N     P=0.002 ** |               P=0.059N     P=0.339N     P=0.643N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma or Hepatocellular Adenoma                                                                          |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 16/50 (32%)  22/50 (44%)  17/49 (35%)  32/50 (64%) |  5/50 (10%)   3/50 (6%)    7/50 (14%)  12/50 (24%) |
|ADJUSTED (b)           |  40.2%        57.5%        49.5%        75.9%      |  15.2%        10.7%        20.5%        33.2%      |
|TERMINAL (d)           | 12/35 (34%)  13/28 (46%)   8/24 (33%)  17/27 (63%) |  5/33 (15%)   3/28 (11%)   4/29 (14%)   9/32 (28%) |
|FIRST INCIDENCE (DAYS) |   456          433          571          456       |   729 (T)      729 (T)      493          549       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P<0.001 **   P=0.064      P=0.183      P<0.001 ** |  P=0.012 *    P=0.448N     P=0.306      P=0.050 *  |
|INCIDENTAL TUMOR       |  P<0.001 **   P=0.103      P=0.548N     P<0.001 ** |  P=0.019 *    P=0.448N     P=0.347      P=0.072    |
|LOGISTIC REGRESSION    |  P<0.001 **   P=0.136      P=0.431      P<0.001 ** |  P=0.011 *    P=0.448N     P=0.352      P=0.051    |
|COCHRAN-ARMITAGE       |  P=0.002 **                                        |  P=0.011 *                                         |
|FISHER EXACT           |               P=0.151      P=0.472      P=0.001 ** |               P=0.357N     P=0.380      P=0.054    |
|=================================================================================================================================|
 
         DATE: 09/03/94                     EXPERIMENT: 05005 TEST: 08                                                 PAGE   6
                                  STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- FURFURAL
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   VEHICLE      50.          100.         175.      |   VEHICLE      50.          100.         175.      |
|                       |   CONTROL      MG/KG        MG/KG        MG/KG     |   CONTROL      MG/KG        MG/KG        MG/KG     |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma                                                         |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 16/50 (32%)  22/50 (44%)  17/49 (35%)  32/50 (64%) |  5/50 (10%)   3/50 (6%)    7/50 (14%)  12/50 (24%) |
|ADJUSTED (b)           |  40.2%        57.5%        49.5%        75.9%      |  15.2%        10.7%        20.5%        33.2%      |
|TERMINAL (d)           | 12/35 (34%)  13/28 (46%)   8/24 (33%)  17/27 (63%) |  5/33 (15%)   3/28 (11%)   4/29 (14%)   9/32 (28%) |
|FIRST INCIDENCE (DAYS) |   456          433          571          456       |   729 (T)      729 (T)      493          549       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P<0.001 **   P=0.064      P=0.183      P<0.001 ** |  P=0.012 *    P=0.448N     P=0.306      P=0.050 *  |
|INCIDENTAL TUMOR       |  P<0.001 **   P=0.103      P=0.548N     P<0.001 ** |  P=0.019 *    P=0.448N     P=0.347      P=0.072    |
|LOGISTIC REGRESSION    |  P<0.001 **   P=0.136      P=0.431      P<0.001 ** |  P=0.011 *    P=0.448N     P=0.352      P=0.051    |
|COCHRAN-ARMITAGE       |  P=0.002 **                                        |  P=0.011 *                                         |
|FISHER EXACT           |               P=0.151      P=0.472      P=0.001 ** |               P=0.357N     P=0.380      P=0.054    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Adenoma                                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  9/50 (18%)   3/50 (6%)    2/49 (4%)    8/50 (16%) |  3/50 (6%)    1/50 (2%)    1/50 (2%)    3/50 (6%)  |
|ADJUSTED (b)           |  24.8%         9.7%         8.3%        26.7%      |   9.1%         3.6%         3.4%         9.4%      |
|TERMINAL (d)           |  8/35 (23%)   2/28 (7%)    2/24 (8%)    6/27 (22%) |  3/33 (9%)    1/28 (4%)    1/29 (3%)    3/32 (9%)  |
|FIRST INCIDENCE (DAYS) |   666          668          729 (T)      576       |   729 (T)      729 (T)      729 (T)      729 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.423      P=0.118N     P=0.092N     P=0.496    |  P=0.525      P=0.365N     P=0.352N     P=0.650    |
|INCIDENTAL TUMOR       |  P=0.484      P=0.076N     P=0.071N     P=0.597    |  P=0.525      P=0.365N     P=0.352N     P=0.650    |
|LOGISTIC REGRESSION    |  P=0.505      P=0.085N     P=0.060N     P=0.601    |  P=0.525      P=0.365N     P=0.352N     P=0.650    |
|COCHRAN-ARMITAGE       |  P=0.502N                                          |  P=0.528                                           |
|FISHER EXACT           |               P=0.061N     P=0.028N*    P=0.500N   |               P=0.309N     P=0.309N     P=0.661N   |
|=================================================================================================================================|
 
         DATE: 09/03/94                     EXPERIMENT: 05005 TEST: 08                                                 PAGE   7
                                  STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- FURFURAL
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   VEHICLE      50.          100.         175.      |   VEHICLE      50.          100.         175.      |
|                       |   CONTROL      MG/KG        MG/KG        MG/KG     |   CONTROL      MG/KG        MG/KG        MG/KG     |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Carcinoma                                                                                              |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  3/50 (6%)    5/50 (10%)   3/49 (6%)    6/50 (12%) |  2/50 (4%)    1/50 (2%)    0/50 (0%)    0/50 (0%)  |
|ADJUSTED (b)           |   8.3%        15.2%        10.6%        20.1%      |   5.3%         3.6%         0.0%         0.0%      |
|TERMINAL (d)           |  2/35 (6%)    3/28 (11%)   2/24 (8%)    4/27 (15%) |  0/33 (0%)    1/28 (4%)    0/29 (0%)    0/32 (0%)  |
|FIRST INCIDENCE (DAYS) |   719          433          599          662       |   620          729 (T)      ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.150      P=0.264      P=0.505      P=0.148    |  P=0.088N     P=0.535N     P=0.268N     P=0.252N   |
|INCIDENTAL TUMOR       |  P=0.193      P=0.355      P=0.656N     P=0.228    |  P=0.066N     P=0.524N     P=0.220N     P=0.197N   |
|LOGISTIC REGRESSION    |  P=0.191      P=0.342      P=0.614      P=0.174    |  P=0.080N     P=0.511N     P=0.237N     P=0.238N   |
|COCHRAN-ARMITAGE       |  P=0.238                                           |  P=0.079N                                          |
|FISHER EXACT           |               P=0.357      P=0.651      P=0.243    |               P=0.500N     P=0.247N     P=0.247N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma                                                              |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 10/50 (20%)   8/50 (16%)   5/49 (10%)  13/50 (26%) |  5/50 (10%)   2/50 (4%)    1/50 (2%)    3/50 (6%)  |
|ADJUSTED (b)           |  26.9%        24.1%        18.8%        41.1%      |  13.9%         7.1%         3.4%         9.4%      |
|TERMINAL (d)           |  8/35 (23%)   5/28 (18%)   4/24 (17%)   9/27 (33%) |  3/33 (9%)    2/28 (7%)    1/29 (3%)    3/32 (9%)  |
|FIRST INCIDENCE (DAYS) |   666          433          599          576       |   620          729 (T)      729 (T)      729 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.125      P=0.570N     P=0.343N     P=0.137    |  P=0.274N     P=0.277N     P=0.138N     P=0.378N   |
|INCIDENTAL TUMOR       |  P=0.179      P=0.418N     P=0.201N     P=0.246    |  P=0.250N     P=0.269N     P=0.119N     P=0.346N   |
|LOGISTIC REGRESSION    |  P=0.184      P=0.442N     P=0.210N     P=0.197    |  P=0.270N     P=0.241N     P=0.116N     P=0.363N   |
|COCHRAN-ARMITAGE       |  P=0.271                                           |  P=0.264N                                          |
|FISHER EXACT           |               P=0.398N     P=0.140N     P=0.318    |               P=0.218N     P=0.102N     P=0.357N   |
|=================================================================================================================================|
 
         DATE: 09/03/94                     EXPERIMENT: 05005 TEST: 08                                                 PAGE   8
                                  STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- FURFURAL
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   VEHICLE      50.          100.         175.      |   VEHICLE      50.          100.         175.      |
|                       |   CONTROL      MG/KG        MG/KG        MG/KG     |   CONTROL      MG/KG        MG/KG        MG/KG     |
|=================================================================================================================================|
|                                                                                                                                 |
|Ovary                                                                                                                            |
|     Cystadenoma                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |                                                    |  2/48 (4%)    1/49 (2%)    0/50 (0%)    1/50 (2%)  |
|ADJUSTED (b)           |                                                    |   6.5%         3.6%         0.0%         3.1%      |
|TERMINAL (d)           |                                                    |  2/31 (6%)    1/28 (4%)    0/29 (0%)    1/32 (3%)  |
|FIRST INCIDENCE (DAYS) |                                                    |   729 (T)      729 (T)      ---          729 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                                                    |  P=0.301N     P=0.536N     P=0.253N     P=0.489N   |
|INCIDENTAL TUMOR       |                                                    |  P=0.301N     P=0.536N     P=0.253N     P=0.489N   |
|LOGISTIC REGRESSION    |                                                    |  P=0.301N     P=0.536N     P=0.253N     P=0.489N   |
|COCHRAN-ARMITAGE       |                                                    |  P=0.300N                                          |
|FISHER EXACT           |                                                    |               P=0.492N     P=0.237N     P=0.485N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/47 (0%)    0/45 (0%)    0/46 (0%)    2/49 (4%)  |  7/46 (15%)   3/49 (6%)    4/49 (8%)    9/49 (18%) |
|ADJUSTED (b)           |   0.0%         0.0%         0.0%         5.9%      |  22.6%        10.3%        13.8%        27.8%      |
|TERMINAL (d)           |  0/33 (0%)    0/27 (0%)    0/23 (0%)    1/27 (4%)  |  7/31 (23%)   2/27 (7%)    4/29 (14%)   8/31 (26%) |
|FIRST INCIDENCE (DAYS) |   ---          ---          ---          464       |   729 (T)      704          729 (T)      643       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.045 *      (e)          (e)        P=0.213    |  P=0.240      P=0.211N     P=0.294N     P=0.386    |
|INCIDENTAL TUMOR       |  P=0.046 *      (e)          (e)        P=0.195    |  P=0.260      P=0.187N     P=0.294N     P=0.431    |
|LOGISTIC REGRESSION    |  P=0.063        (e)          (e)        P=0.261    |  P=0.224      P=0.173N     P=0.294N     P=0.385    |
|COCHRAN-ARMITAGE       |  P=0.054                                           |  P=0.256                                           |
|FISHER EXACT           |                 (e)          (e)        P=0.258    |               P=0.134N     P=0.226N     P=0.447    |
|=================================================================================================================================|
 
         DATE: 09/03/94                     EXPERIMENT: 05005 TEST: 08                                                 PAGE   9
                                  STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- FURFURAL
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   VEHICLE      50.          100.         175.      |   VEHICLE      50.          100.         175.      |
|                       |   CONTROL      MG/KG        MG/KG        MG/KG     |   CONTROL      MG/KG        MG/KG        MG/KG     |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Squamous Cell Carcinoma                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/50 (2%)    0/50 (0%)    0/49 (0%)    2/50 (4%)  |  0/50 (0%)    0/50 (0%)    0/50 (0%)    1/50 (2%)  |
|ADJUSTED (b)           |   2.1%         0.0%         0.0%         7.4%      |   0.0%         0.0%         0.0%         3.1%      |
|TERMINAL (d)           |  0/35 (0%)    0/28 (0%)    0/24 (0%)    2/27 (7%)  |  0/33 (0%)    0/28 (0%)    0/29 (0%)    1/32 (3%)  |
|FIRST INCIDENCE (DAYS) |   456          ---          ---          729 (T)   |   ---          ---          ---          729 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.231      P=0.504N     P=0.509N     P=0.433    |  P=0.197        (e)          (e)        P=0.494    |
|INCIDENTAL TUMOR       |  P=0.225      P=0.545N     P=0.500N     P=0.415    |  P=0.197        (e)          (e)        P=0.494    |
|LOGISTIC REGRESSION    |  P=0.269      P=0.481N     P=0.540N     P=0.499    |  P=0.197        (e)          (e)        P=0.494    |
|COCHRAN-ARMITAGE       |  P=0.268                                           |  P=0.191                                           |
|FISHER EXACT           |               P=0.500N     P=0.505N     P=0.500    |                 (e)          (e)        P=0.500    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Squamous Cell Carcinoma, Papilloma Squamous, or Papilloma                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/50 (2%)    2/50 (4%)    0/49 (0%)    2/50 (4%)  |  1/50 (2%)    0/50 (0%)    0/50 (0%)    1/50 (2%)  |
|ADJUSTED (b)           |   2.1%         7.1%         0.0%         7.4%      |   3.0%         0.0%         0.0%         3.1%      |
|TERMINAL (d)           |  0/35 (0%)    2/28 (7%)    0/24 (0%)    2/27 (7%)  |  1/33 (3%)    0/28 (0%)    0/29 (0%)    1/32 (3%)  |
|FIRST INCIDENCE (DAYS) |   456          729 (T)      ---          729 (T)   |   729 (T)      ---          ---          729 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.410      P=0.446      P=0.509N     P=0.433    |  P=0.604      P=0.533N     P=0.526N     P=0.755    |
|INCIDENTAL TUMOR       |  P=0.405      P=0.423      P=0.500N     P=0.415    |  P=0.604      P=0.533N     P=0.526N     P=0.755    |
|LOGISTIC REGRESSION    |  P=0.464      P=0.504      P=0.540N     P=0.499    |  P=0.604      P=0.533N     P=0.526N     P=0.757    |
|COCHRAN-ARMITAGE       |  P=0.483                                           |  P=0.608                                           |
|FISHER EXACT           |               P=0.500      P=0.505N     P=0.500    |               P=0.500N     P=0.500N     P=0.753N   |
|=================================================================================================================================|
 
         DATE: 09/03/94                     EXPERIMENT: 05005 TEST: 08                                                 PAGE  10
                                  STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- FURFURAL
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   VEHICLE      50.          100.         175.      |   VEHICLE      50.          100.         175.      |
|                       |   CONTROL      MG/KG        MG/KG        MG/KG     |   CONTROL      MG/KG        MG/KG        MG/KG     |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Squamous Cell Papilloma                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    2/50 (4%)    0/49 (0%)    0/50 (0%)  |  1/50 (2%)    0/50 (0%)    0/50 (0%)    0/50 (0%)  |
|ADJUSTED (b)           |   0.0%         7.1%         0.0%         0.0%      |   3.0%         0.0%         0.0%         0.0%      |
|TERMINAL (d)           |  0/35 (0%)    2/28 (7%)    0/24 (0%)    0/27 (0%)  |  1/33 (3%)    0/28 (0%)    0/29 (0%)    0/32 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          729 (T)      ---          ---       |   729 (T)      ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.445N     P=0.190        (e)          (e)      |  P=0.254N     P=0.533N     P=0.526N     P=0.506N   |
|INCIDENTAL TUMOR       |  P=0.445N     P=0.190        (e)          (e)      |  P=0.254N     P=0.533N     P=0.526N     P=0.506N   |
|LOGISTIC REGRESSION    |  P=0.445N     P=0.190        (e)          (e)      |  P=0.254N     P=0.533N     P=0.526N     P=0.506N   |
|COCHRAN-ARMITAGE       |  P=0.390N                                          |  P=0.248N                                          |
|FISHER EXACT           |               P=0.247        (e)          (e)      |               P=0.500N     P=0.500N     P=0.500N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Trichoepithelioma, Kertatocanthoma, Squamous Cell Carcinoma,                                                                |
|     Basal Cell Carcinoma or Adenoma, Papilloma Squamous, or Papilloma                                                           |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/50 (2%)    3/50 (6%)    1/49 (2%)    2/50 (4%)  |  1/50 (2%)    0/50 (0%)    0/50 (0%)    1/50 (2%)  |
|ADJUSTED (b)           |   2.1%        10.7%         4.2%         7.4%      |   3.0%         0.0%         0.0%         3.1%      |
|TERMINAL (d)           |  0/35 (0%)    3/28 (11%)   1/24 (4%)    2/27 (7%)  |  1/33 (3%)    0/28 (0%)    0/29 (0%)    1/32 (3%)  |
|FIRST INCIDENCE (DAYS) |   456          729 (T)      729 (T)      729 (T)   |   729 (T)      ---          ---          729 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.422      P=0.247      P=0.714      P=0.433    |  P=0.604      P=0.533N     P=0.526N     P=0.755    |
|INCIDENTAL TUMOR       |  P=0.417      P=0.231      P=0.719      P=0.415    |  P=0.604      P=0.533N     P=0.526N     P=0.755    |
|LOGISTIC REGRESSION    |  P=0.481      P=0.303      P=0.756      P=0.499    |  P=0.604      P=0.533N     P=0.526N     P=0.757    |
|COCHRAN-ARMITAGE       |  P=0.514                                           |  P=0.608                                           |
|FISHER EXACT           |               P=0.309      P=0.747      P=0.500    |               P=0.500N     P=0.500N     P=0.753N   |
|=================================================================================================================================|
 
         DATE: 09/03/94                     EXPERIMENT: 05005 TEST: 08                                                 PAGE  11
                                  STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- FURFURAL
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   VEHICLE      50.          100.         175.      |   VEHICLE      50.          100.         175.      |
|                       |   CONTROL      MG/KG        MG/KG        MG/KG     |   CONTROL      MG/KG        MG/KG        MG/KG     |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin: Subcutaneous Tissue                                                                                                        |
|     Fibroma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  3/50 (6%)    1/50 (2%)    2/49 (4%)    1/50 (2%)  |  0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)  |
|ADJUSTED (b)           |   8.6%         3.6%         8.3%         3.7%      |   0.0%         0.0%         0.0%         0.0%      |
|TERMINAL (d)           |  3/35 (9%)    1/28 (4%)    2/24 (8%)    1/27 (4%)  |  0/33 (0%)    0/28 (0%)    0/29 (0%)    0/32 (0%)  |
|FIRST INCIDENCE (DAYS) |   729 (T)      729 (T)      729 (T)      729 (T)   |   ---          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.361N     P=0.387N     P=0.670N     P=0.401N   |    (e)          (e)          (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.361N     P=0.387N     P=0.670N     P=0.401N   |    (e)          (e)          (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.361N     P=0.387N     P=0.670N     P=0.401N   |    (e)          (e)          (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.266N                                          |    (e)                                             |
|FISHER EXACT           |               P=0.309N     P=0.510N     P=0.309N   |                 (e)          (e)          (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin: Subcutaneous Tissue                                                                                                        |
|     Fibrosarcoma                                                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  3/50 (6%)    6/50 (12%)  10/49 (20%)   2/50 (4%)  |  2/50 (4%)    0/50 (0%)    1/50 (2%)    2/50 (4%)  |
|ADJUSTED (b)           |   7.6%        18.4%        25.2%         5.9%      |   5.2%         0.0%         2.9%         5.7%      |
|TERMINAL (d)           |  1/35 (3%)    3/28 (11%)   1/24 (4%)    1/27 (4%)  |  1/33 (3%)    0/28 (0%)    0/29 (0%)    1/32 (3%)  |
|FIRST INCIDENCE (DAYS) |   611          609          459          464       |   492          ---          648          643       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.509      P=0.179      P=0.026 *    P=0.579N   |  P=0.480      P=0.271N     P=0.524N     P=0.686    |
|INCIDENTAL TUMOR       |  P=0.390N     P=0.366      P=0.197      P=0.480N   |  P=0.493      P=0.212N     P=0.448N     P=0.685N   |
|LOGISTIC REGRESSION    |  P=0.432N     P=0.228      P=0.154      P=0.502N   |  P=0.478      P=0.231N     P=0.501N     P=0.691    |
|COCHRAN-ARMITAGE       |  P=0.478N                                          |  P=0.481                                           |
|FISHER EXACT           |               P=0.243      P=0.033 *    P=0.500N   |               P=0.247N     P=0.500N     P=0.691N   |
|=================================================================================================================================|
 
         DATE: 09/03/94                     EXPERIMENT: 05005 TEST: 08                                                 PAGE  12
                                  STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- FURFURAL
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   VEHICLE      50.          100.         175.      |   VEHICLE      50.          100.         175.      |
|                       |   CONTROL      MG/KG        MG/KG        MG/KG     |   CONTROL      MG/KG        MG/KG        MG/KG     |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin: Subcutaneous Tissue                                                                                                        |
|     Hemangiosarcoma                                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/50 (4%)    1/50 (2%)    1/49 (2%)    1/50 (2%)  |  1/50 (2%)    0/50 (0%)    0/50 (0%)    1/50 (2%)  |
|ADJUSTED (b)           |   5.5%         3.6%         2.1%         3.2%      |   3.0%         0.0%         0.0%         2.4%      |
|TERMINAL (d)           |  1/35 (3%)    1/28 (4%)    0/24 (0%)    0/27 (0%)  |  1/33 (3%)    0/28 (0%)    0/29 (0%)    0/32 (0%)  |
|FIRST INCIDENCE (DAYS) |   703          729 (T)      403          696       |   729 (T)      ---          ---          615       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.444N     P=0.580N     P=0.579N     P=0.574N   |  P=0.603      P=0.533N     P=0.526N     P=0.757    |
|INCIDENTAL TUMOR       |  P=0.388N     P=0.474N     P=0.477N     P=0.420N   |  P=0.622N     P=0.533N     P=0.526N     P=0.701N   |
|LOGISTIC REGRESSION    |  P=0.385N     P=0.543N     P=0.508N     P=0.541N   |  P=0.608      P=0.533N     P=0.526N     P=0.762N   |
|COCHRAN-ARMITAGE       |  P=0.381N                                          |  P=0.608                                           |
|FISHER EXACT           |               P=0.500N     P=0.508N     P=0.500N   |               P=0.500N     P=0.500N     P=0.753N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin: Subcutaneous Tissue                                                                                                        |
|     Neurofibrosarcoma, Fibrosarcoma, Sarcoma,                                                                                   |
|     Neurofibroma, or Fibroma                                                                                                    |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  5/50 (10%)   7/50 (14%)  13/49 (27%)   3/50 (6%)  |  2/50 (4%)    0/50 (0%)    1/50 (2%)    2/50 (4%)  |
|ADJUSTED (b)           |  13.0%        21.6%        34.9%         9.6%      |   5.2%         0.0%         2.9%         5.7%      |
|TERMINAL (d)           |  3/35 (9%)    4/28 (14%)   4/24 (17%)   2/27 (7%)  |  1/33 (3%)    0/28 (0%)    0/29 (0%)    1/32 (3%)  |
|FIRST INCIDENCE (DAYS) |   611          609          459          464       |   492          ---          648          643       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.506      P=0.270      P=0.016 *    P=0.475N   |  P=0.480      P=0.271N     P=0.524N     P=0.686    |
|INCIDENTAL TUMOR       |  P=0.409N     P=0.465      P=0.108      P=0.395N   |  P=0.493      P=0.212N     P=0.448N     P=0.685N   |
|LOGISTIC REGRESSION    |  P=0.427N     P=0.350      P=0.102      P=0.387N   |  P=0.478      P=0.231N     P=0.501N     P=0.691    |
|COCHRAN-ARMITAGE       |  P=0.428N                                          |  P=0.481                                           |
|FISHER EXACT           |               P=0.380      P=0.030 *    P=0.357N   |               P=0.247N     P=0.500N     P=0.691N   |
|=================================================================================================================================|
 
         DATE: 09/03/94                     EXPERIMENT: 05005 TEST: 08                                                 PAGE  13
                                  STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- FURFURAL
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   VEHICLE      50.          100.         175.      |   VEHICLE      50.          100.         175.      |
|                       |   CONTROL      MG/KG        MG/KG        MG/KG     |   CONTROL      MG/KG        MG/KG        MG/KG     |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin: Subcutaneous Tissue                                                                                                        |
|     Neurofibrosarcoma, Fibrosarcoma, or Sarcoma                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  3/50 (6%)    6/50 (12%)  11/49 (22%)   2/50 (4%)  |  2/50 (4%)    0/50 (0%)    1/50 (2%)    2/50 (4%)  |
|ADJUSTED (b)           |   7.6%        18.4%        28.4%         5.9%      |   5.2%         0.0%         2.9%         5.7%      |
|TERMINAL (d)           |  1/35 (3%)    3/28 (11%)   2/24 (8%)    1/27 (4%)  |  1/33 (3%)    0/28 (0%)    0/29 (0%)    1/32 (3%)  |
|FIRST INCIDENCE (DAYS) |   611          609          459          464       |   492          ---          648          643       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.476      P=0.179      P=0.014 *    P=0.579N   |  P=0.480      P=0.271N     P=0.524N     P=0.686    |
|INCIDENTAL TUMOR       |  P=0.430N     P=0.366      P=0.117      P=0.480N   |  P=0.493      P=0.212N     P=0.448N     P=0.685N   |
|LOGISTIC REGRESSION    |  P=0.469N     P=0.228      P=0.091      P=0.502N   |  P=0.478      P=0.231N     P=0.501N     P=0.691    |
|COCHRAN-ARMITAGE       |  P=0.505N                                          |  P=0.481                                           |
|FISHER EXACT           |               P=0.243      P=0.018 *    P=0.500N   |               P=0.247N     P=0.500N     P=0.691N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Spleen                                                                                                                           |
|     Hemangiosarcoma                                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/50 (4%)    2/50 (4%)    0/48 (0%)    0/49 (0%)  |  1/50 (2%)    1/50 (2%)    0/50 (0%)    1/50 (2%)  |
|ADJUSTED (b)           |   5.5%         6.8%         0.0%         0.0%      |   3.0%         2.6%         0.0%         2.4%      |
|TERMINAL (d)           |  1/35 (3%)    1/28 (4%)    0/24 (0%)    0/27 (0%)  |  1/33 (3%)    0/28 (0%)    0/29 (0%)    0/32 (0%)  |
|FIRST INCIDENCE (DAYS) |   703          697          ---          ---       |   729 (T)      630          ---          615       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.105N     P=0.610      P=0.319N     P=0.293N   |  P=0.567N     P=0.736      P=0.526N     P=0.757    |
|INCIDENTAL TUMOR       |  P=0.067N     P=0.615N     P=0.212N     P=0.214N   |  P=0.427N     P=0.685      P=0.526N     P=0.701N   |
|LOGISTIC REGRESSION    |  P=0.087N     P=0.664      P=0.275N     P=0.266N   |  P=0.566N     P=0.757      P=0.526N     P=0.762N   |
|COCHRAN-ARMITAGE       |  P=0.074N                                          |  P=0.565N                                          |
|FISHER EXACT           |               P=0.691N     P=0.258N     P=0.253N   |               P=0.753N     P=0.500N     P=0.753N   |
|=================================================================================================================================|
 
         DATE: 09/03/94                     EXPERIMENT: 05005 TEST: 08                                                 PAGE  14
                                  STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- FURFURAL
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   VEHICLE      50.          100.         175.      |   VEHICLE      50.          100.         175.      |
|                       |   CONTROL      MG/KG        MG/KG        MG/KG     |   CONTROL      MG/KG        MG/KG        MG/KG     |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach                                                                                                             |
|     Squamous Cell Carcinoma or Papilloma Squamous                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/50 (4%)    0/50 (0%)    0/49 (0%)    1/50 (2%)  |  1/50 (2%)    0/50 (0%)    1/50 (2%)    6/50 (12%) |
|ADJUSTED (b)           |   5.6%         0.0%         0.0%         3.7%      |   3.0%         0.0%         2.4%        15.4%      |
|TERMINAL (d)           |  1/35 (3%)    0/28 (0%)    0/24 (0%)    1/27 (4%)  |  1/33 (3%)    0/28 (0%)    0/29 (0%)    2/32 (6%)  |
|FIRST INCIDENCE (DAYS) |   719          ---          ---          729 (T)   |   729 (T)      ---          523          596       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.452N     P=0.293N     P=0.329N     P=0.581N   |  P=0.006 **   P=0.533N     P=0.741      P=0.061    |
|INCIDENTAL TUMOR       |  P=0.411N     P=0.186N     P=0.212N     P=0.506N   |  P=0.015 *    P=0.533N     P=0.732N     P=0.113    |
|LOGISTIC REGRESSION    |  P=0.432N     P=0.270N     P=0.293N     P=0.557N   |  P=0.005 **   P=0.533N     P=0.763      P=0.058    |
|COCHRAN-ARMITAGE       |  P=0.390N                                          |  P=0.005 **                                        |
|FISHER EXACT           |               P=0.247N     P=0.253N     P=0.500N   |               P=0.500N     P=0.753N     P=0.056    |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach                                                                                                             |
|     Squamous Cell Papilloma                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/50 (2%)    0/50 (0%)    0/49 (0%)    1/50 (2%)  |  1/50 (2%)    0/50 (0%)    1/50 (2%)    6/50 (12%) |
|ADJUSTED (b)           |   2.9%         0.0%         0.0%         3.7%      |   3.0%         0.0%         2.4%        15.4%      |
|TERMINAL (d)           |  1/35 (3%)    0/28 (0%)    0/24 (0%)    1/27 (4%)  |  1/33 (3%)    0/28 (0%)    0/29 (0%)    2/32 (6%)  |
|FIRST INCIDENCE (DAYS) |   729 (T)      ---          ---          729 (T)   |   729 (T)      ---          523          596       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.551      P=0.545N     P=0.575N     P=0.703    |  P=0.006 **   P=0.533N     P=0.741      P=0.061    |
|INCIDENTAL TUMOR       |  P=0.551      P=0.545N     P=0.575N     P=0.703    |  P=0.015 *    P=0.533N     P=0.732N     P=0.113    |
|LOGISTIC REGRESSION    |  P=0.551      P=0.545N     P=0.575N     P=0.703    |  P=0.005 **   P=0.533N     P=0.763      P=0.058    |
|COCHRAN-ARMITAGE       |  P=0.607                                           |  P=0.005 **                                        |
|FISHER EXACT           |               P=0.500N     P=0.505N     P=0.753N   |               P=0.500N     P=0.753N     P=0.056    |
|=================================================================================================================================|
 
         DATE: 09/03/94                     EXPERIMENT: 05005 TEST: 08                                                 PAGE  15
                                  STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- FURFURAL
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   VEHICLE      50.          100.         175.      |   VEHICLE      50.          100.         175.      |
|                       |   CONTROL      MG/KG        MG/KG        MG/KG     |   CONTROL      MG/KG        MG/KG        MG/KG     |
|=================================================================================================================================|
|                                                                                                                                 |
|Testes                                                                                                                           |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/50 (2%)    0/50 (0%)    2/49 (4%)    0/50 (0%)  |                                                    |
|ADJUSTED (b)           |   2.9%         0.0%         7.9%         0.0%      |                                                    |
|TERMINAL (d)           |  1/35 (3%)    0/28 (0%)    1/24 (4%)    0/27 (0%)  |                                                    |
|FIRST INCIDENCE (DAYS) |   729 (T)      ---          713          ---       |                                                    |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.540N     P=0.545N     P=0.376      P=0.552N   |                                                    |
|INCIDENTAL TUMOR       |  P=0.503N     P=0.545N     P=0.479      P=0.552N   |                                                    |
|LOGISTIC REGRESSION    |  P=0.521N     P=0.545N     P=0.411      P=0.552N   |                                                    |
|COCHRAN-ARMITAGE       |  P=0.480N                                          |                                                    |
|FISHER EXACT           |               P=0.500N     P=0.492      P=0.500N   |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: Follicular Cell                                                                                                   |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/49 (2%)    0/50 (0%)    0/48 (0%)    2/50 (4%)  |  2/50 (4%)    1/50 (2%)    4/49 (8%)    2/50 (4%)  |
|ADJUSTED (b)           |   2.9%         0.0%         0.0%         7.0%      |   6.1%         3.6%        13.8%         6.3%      |
|TERMINAL (d)           |  1/35 (3%)    0/28 (0%)    0/24 (0%)    1/27 (4%)  |  2/33 (6%)    1/28 (4%)    4/29 (14%)   2/32 (6%)  |
|FIRST INCIDENCE (DAYS) |   729 (T)      ---          ---          728       |   729 (T)      729 (T)      729 (T)      729 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.225      P=0.545N     P=0.575N     P=0.419    |  P=0.431      P=0.558N     P=0.277      P=0.685    |
|INCIDENTAL TUMOR       |  P=0.248      P=0.545N     P=0.575N     P=0.494    |  P=0.431      P=0.558N     P=0.277      P=0.685    |
|LOGISTIC REGRESSION    |  P=0.236      P=0.545N     P=0.575N     P=0.436    |  P=0.431      P=0.558N     P=0.277      P=0.685    |
|COCHRAN-ARMITAGE       |  P=0.271                                           |  P=0.430                                           |
|FISHER EXACT           |               P=0.495N     P=0.505N     P=0.508    |               P=0.500N     P=0.329      P=0.691N   |
|=================================================================================================================================|
 
         DATE: 09/03/94                     EXPERIMENT: 05005 TEST: 08                                                 PAGE  16
                                  STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- FURFURAL
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   VEHICLE      50.          100.         175.      |   VEHICLE      50.          100.         175.      |
|                       |   CONTROL      MG/KG        MG/KG        MG/KG     |   CONTROL      MG/KG        MG/KG        MG/KG     |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Hemangiosarcoma                                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/50 (4%)    7/50 (14%)   4/49 (8%)    1/50 (2%)  |  2/50 (4%)    1/50 (2%)    0/50 (0%)    1/50 (2%)  |
|ADJUSTED (b)           |   5.5%        19.6%        12.6%         3.2%      |   5.7%         2.6%         0.0%         2.4%      |
|TERMINAL (d)           |  1/35 (3%)    2/28 (7%)    2/24 (8%)    0/27 (0%)  |  1/33 (3%)    0/28 (0%)    0/29 (0%)    0/32 (0%)  |
|FIRST INCIDENCE (DAYS) |   703          491          403          696       |   662          630          ---          615       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.325N     P=0.056      P=0.234      P=0.574N   |  P=0.322N     P=0.531N     P=0.260N     P=0.510N   |
|INCIDENTAL TUMOR       |  P=0.198N     P=0.149      P=0.376      P=0.420N   |  P=0.233N     P=0.524N     P=0.233N     P=0.463N   |
|LOGISTIC REGRESSION    |  P=0.238N     P=0.078      P=0.329      P=0.541N   |  P=0.311N     P=0.506N     P=0.246N     P=0.500N   |
|COCHRAN-ARMITAGE       |  P=0.228N                                          |  P=0.311N                                          |
|FISHER EXACT           |               P=0.080      P=0.329      P=0.500N   |               P=0.500N     P=0.247N     P=0.500N   |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Hemangiosarcoma or Hemangioma                                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  3/50 (6%)    8/50 (16%)   4/49 (8%)    1/50 (2%)  |  2/50 (4%)    2/50 (4%)    1/50 (2%)    1/50 (2%)  |
|ADJUSTED (b)           |   7.6%        22.7%        12.6%         3.2%      |   5.7%         6.1%         2.6%         2.4%      |
|TERMINAL (d)           |  1/35 (3%)    3/28 (11%)   2/24 (8%)    0/27 (0%)  |  1/33 (3%)    1/28 (4%)    0/29 (0%)    0/32 (0%)  |
|FIRST INCIDENCE (DAYS) |   518          491          403          696       |   662          630          574          615       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.204N     P=0.070      P=0.386      P=0.376N   |  P=0.324N     P=0.653      P=0.533N     P=0.510N   |
|INCIDENTAL TUMOR       |  P=0.111N     P=0.155      P=0.542      P=0.263N   |  P=0.212N     P=0.662      P=0.494N     P=0.463N   |
|LOGISTIC REGRESSION    |  P=0.129N     P=0.098      P=0.491      P=0.318N   |  P=0.315N     P=0.682      P=0.499N     P=0.500N   |
|COCHRAN-ARMITAGE       |  P=0.124N                                          |  P=0.314N                                          |
|FISHER EXACT           |               P=0.100      P=0.489      P=0.309N   |               P=0.691N     P=0.500N     P=0.500N   |
|=================================================================================================================================|
 
         DATE: 09/03/94                     EXPERIMENT: 05005 TEST: 08                                                 PAGE  17
                                  STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- FURFURAL
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   VEHICLE      50.          100.         175.      |   VEHICLE      50.          100.         175.      |
|                       |   CONTROL      MG/KG        MG/KG        MG/KG     |   CONTROL      MG/KG        MG/KG        MG/KG     |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Histiocytic Sarcoma                                                                                                         |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    0/50 (0%)    1/49 (2%)    0/50 (0%)  |  0/50 (0%)    2/50 (4%)    0/50 (0%)    0/50 (0%)  |
|ADJUSTED (b)           |   0.0%         0.0%         2.9%         0.0%      |   0.0%         6.9%         0.0%         0.0%      |
|TERMINAL (d)           |  0/35 (0%)    0/28 (0%)    0/24 (0%)    0/27 (0%)  |  0/33 (0%)    1/28 (4%)    0/29 (0%)    0/32 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          638          ---       |   ---          719          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.589        (e)        P=0.468        (e)      |  P=0.393N     P=0.208        (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.704        (e)        P=0.739        (e)      |  P=0.418N     P=0.271        (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.612        (e)        P=0.497        (e)      |  P=0.395N     P=0.220        (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.610                                           |  P=0.389N                                          |
|FISHER EXACT           |                 (e)        P=0.495        (e)      |               P=0.247        (e)          (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant Lymphoma And Histiocytic Sarcoma                                                                                  |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  5/50 (10%)   2/50 (4%)    8/49 (16%)   4/50 (8%)  |  9/50 (18%)  15/50 (30%)   9/50 (18%)   8/50 (16%) |
|ADJUSTED (b)           |  13.6%         6.1%        24.9%        13.1%      |  23.7%        42.1%        31.0%        21.3%      |
|TERMINAL (d)           |  4/35 (11%)   1/28 (4%)    3/24 (13%)   2/27 (7%)  |  5/33 (15%)   8/28 (29%)   9/29 (31%)   5/32 (16%) |
|FIRST INCIDENCE (DAYS) |   662          647          401          662       |   576          492          729 (T)      526       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.339      P=0.298N     P=0.132      P=0.633N   |  P=0.272N     P=0.081      P=0.491      P=0.521N   |
|INCIDENTAL TUMOR       |  P=0.455      P=0.200N     P=0.337      P=0.512N   |  P=0.228N     P=0.110      P=0.539      P=0.482N   |
|LOGISTIC REGRESSION    |  P=0.415      P=0.241N     P=0.253      P=0.579N   |  P=0.247N     P=0.058      P=0.546      P=0.498N   |
|COCHRAN-ARMITAGE       |  P=0.466                                           |  P=0.253N                                          |
|FISHER EXACT           |               P=0.218N     P=0.264      P=0.500N   |               P=0.121      P=0.602N     P=0.500N   |
|=================================================================================================================================|
 
         DATE: 09/03/94                     EXPERIMENT: 05005 TEST: 08                                                 PAGE  18
                                  STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- FURFURAL
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   VEHICLE      50.          100.         175.      |   VEHICLE      50.          100.         175.      |
|                       |   CONTROL      MG/KG        MG/KG        MG/KG     |   CONTROL      MG/KG        MG/KG        MG/KG     |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed,                                                                        |
|     NOS, or Undifferentiated Cell Type                                                                                          |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  5/50 (10%)   2/50 (4%)    7/49 (14%)   4/50 (8%)  |  9/50 (18%)  13/50 (26%)   9/50 (18%)   8/50 (16%) |
|ADJUSTED (b)           |  13.6%         6.1%        22.6%        13.1%      |  23.7%        37.1%        31.0%        21.3%      |
|TERMINAL (d)           |  4/35 (11%)   1/28 (4%)    3/24 (13%)   2/27 (7%)  |  5/33 (15%)   7/28 (25%)   9/29 (31%)   5/32 (16%) |
|FIRST INCIDENCE (DAYS) |   662          647          401          662       |   576          492          729 (T)      526       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.365      P=0.298N     P=0.201      P=0.633N   |  P=0.324N     P=0.167      P=0.491      P=0.521N   |
|INCIDENTAL TUMOR       |  P=0.467      P=0.200N     P=0.387      P=0.512N   |  P=0.273N     P=0.216      P=0.539      P=0.482N   |
|LOGISTIC REGRESSION    |  P=0.442      P=0.241N     P=0.351      P=0.579N   |  P=0.301N     P=0.134      P=0.546      P=0.498N   |
|COCHRAN-ARMITAGE       |  P=0.495                                           |  P=0.307N                                          |
|FISHER EXACT           |               P=0.218N     P=0.365      P=0.500N   |               P=0.235      P=0.602N     P=0.500N   |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Benign Tumors                                                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 24/50 (48%)  24/50 (48%)  20/49 (41%)  30/50 (60%) | 16/50 (32%)  14/50 (28%)  16/50 (32%)  23/50 (46%) |
|ADJUSTED (b)           |  62.8%        67.8%        66.0%        83.1%      |  47.1%        48.1%        45.6%        59.6%      |
|TERMINAL (d)           | 21/35 (60%)  17/28 (61%)  14/24 (58%)  21/27 (78%) | 15/33 (45%)  13/28 (46%)  11/29 (38%)  17/32 (53%) |
|FIRST INCIDENCE (DAYS) |   518          491          571          464       |   700          704          493          442       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.016 *    P=0.237      P=0.312      P=0.013 *  |  P=0.057      P=0.563      P=0.427      P=0.088    |
|INCIDENTAL TUMOR       |  P=0.030 *    P=0.390      P=0.566N     P=0.035 *  |  P=0.070      P=0.580N     P=0.500      P=0.124    |
|LOGISTIC REGRESSION    |  P=0.041 *    P=0.483      P=0.490N     P=0.039 *  |  P=0.054      P=0.521N     P=0.507      P=0.094    |
|COCHRAN-ARMITAGE       |  P=0.158                                           |  P=0.059                                           |
|FISHER EXACT           |               P=0.579N     P=0.303N     P=0.158    |               P=0.414N     P=0.585N     P=0.109    |
|=================================================================================================================================|
 
         DATE: 09/03/94                     EXPERIMENT: 05005 TEST: 08                                                 PAGE  19
                                  STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- FURFURAL
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   VEHICLE      50.          100.         175.      |   VEHICLE      50.          100.         175.      |
|                       |   CONTROL      MG/KG        MG/KG        MG/KG     |   CONTROL      MG/KG        MG/KG        MG/KG     |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant Tumors                                                                                                            |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 22/50 (44%)  31/50 (62%)  27/49 (55%)  33/50 (66%) | 22/50 (44%)  20/50 (40%)  12/50 (24%)  16/50 (32%) |
|ADJUSTED (b)           |  49.7%        68.7%        62.1%        78.4%      |  52.1%        53.6%        38.1%        39.6%      |
|TERMINAL (d)           | 13/35 (37%)  14/28 (50%)   9/24 (38%)  18/27 (67%) | 13/33 (39%)  11/28 (39%)  10/29 (34%)   9/32 (28%) |
|FIRST INCIDENCE (DAYS) |   456          433          401          456       |   492          492          611          526       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.014 *    P=0.030 *    P=0.061      P=0.007 ** |  P=0.096N     P=0.530      P=0.083N     P=0.206N   |
|INCIDENTAL TUMOR       |  P=0.022 *    P=0.108      P=0.582      P=0.010 *  |  P=0.034N*    P=0.479N     P=0.037N*    P=0.105N   |
|LOGISTIC REGRESSION    |  P=0.015 *    P=0.105      P=0.491      P=0.007 ** |  P=0.031N*    P=0.544      P=0.041N*    P=0.092N   |
|COCHRAN-ARMITAGE       |  P=0.036 *                                         |  P=0.067N                                          |
|FISHER EXACT           |               P=0.054      P=0.183      P=0.022 *  |               P=0.420N     P=0.028N*    P=0.151N   |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant and Benign Tumors                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 38/50 (76%)  41/50 (82%)  42/49 (86%)  43/50 (86%) | 33/50 (66%)  26/50 (52%)  24/50 (48%)  31/50 (62%) |
|ADJUSTED (b)           |  84.4%        89.1%        89.4%        97.7%      |  78.5%        70.0%        67.7%        73.2%      |
|TERMINAL (d)           | 28/35 (80%)  23/28 (82%)  19/24 (79%)  26/27 (96%) | 24/33 (73%)  17/28 (61%)  18/29 (62%)  21/32 (66%) |
|FIRST INCIDENCE (DAYS) |   456          433          401          456       |   492          492          493          442       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.018 *    P=0.075      P=0.015 *    P=0.014 *  |  P=0.434N     P=0.358N     P=0.190N     P=0.488N   |
|INCIDENTAL TUMOR       |  P=0.013 *    P=0.289      P=0.384      P=0.012 *  |  P=0.280N     P=0.191N     P=0.081N     P=0.341N   |
|LOGISTIC REGRESSION    |  P=0.011 *    P=0.232      P=0.292      P=0.013 *  |  P=0.312N     P=0.173N     P=0.071N     P=0.405N   |
|COCHRAN-ARMITAGE       |  P=0.109                                           |  P=0.412N                                          |
|FISHER EXACT           |               P=0.312      P=0.166      P=0.154    |               P=0.111N     P=0.053N     P=0.418N   |
|=================================================================================================================================|
 
         DATE: 09/03/94                     EXPERIMENT: 05005 TEST: 08                                                 PAGE  20
                                  STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- FURFURAL
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
 
 (a)  Number of tumor-bearing animals / number of animals examined at site.
 (b)  Kaplan-Meier estimated lifetime tumor incidence after adjustment for 
      intercurrent mortality.
 (d)  Observed incidence at terminal kill.
 (f)  Beneath the control incidence are the P-values associated with the trend 
      test.  Beneath the dosed group incidence are the P-values corresponding to 
      pairwise comparisons between the controls and that dosed group.  The life
      table analysis regards tumors in animals dying  prior to terminal kill as
      being (directly or indirectly) the cause of death.  The incidental tumor 
      test regards these lesions as non-fatal.  Logistic regression is an alternative
      method for analyzing the incidence of non-fatal tumors.  The Cochran-Armitage
      and Fisher's exact tests compare directly the overall incidence rates.  
      For all tests, a negative trend is indicated by "N".
 (e)  Value of Statistic cannot be computed. 
 (I)  Interim sacrifice
 (T)  Terminal sacrifice
  #   Tumor rates based on number of animals necropsied.
 
  *   To the right of any statistical result, indicates significance at (P<=0.05).
  **  To the right of any statistical result, indicates significance at (P<=0.01).

--multipart-boundary
Content-type: text/plain
Range: bytes 135946-135946/135946


--multipart-boundary--