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TR 382 Mouse Pathology Tables

NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11 
LAB: Southern Research Inst                                    DATE: 09/03/94   
EXP: 05005                        FURFURAL                     TIME: 06:59:34   
TEST: 08              CAGES FROM 0000 TO LAST CAGE             PAGE:   1        
TEST TYPE: CHRONIC          ROUTE: GAVAGE                      NTP C#: 56177    
CONT: NO1CP9565101                                             CAS: 98-01-1     
PATHOLOGIST: H. GILES                        S. EUSTIS                          
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REASONS FOR REMOVAL:                                                            
                                                                                
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NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11
LAB: Southern Research Inst                                    DATE: 09/03/94  
EXP: 05005                        FURFURAL                     TIME: 06:59:34  
TEST: 08              CAGES FROM 0000 TO LAST CAGE                             
TEST TYPE: CHRONIC          ROUTE: GAVAGE                      NTP C#: 56177   
CONT: NO1CP9565101                                             CAS: 98-01-1    
PATHOLOGIST: H. GILES                        S. EUSTIS                         

                                     FURFURAL


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 729 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                          DOSE = VEHICLE CONTROL                                |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 15     CENSORED DEATHS 0    TERMINAL 35        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      2     121   375   456   456   473   518   580   611   622                 |
 |      662   666   676   703   719                                               |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = 50.     MG/KG                                  |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 20     CENSORED DEATHS 2    TERMINAL 28        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      205   433   491   492   506   563   573   579   595   609                 |
 |      647   652   668   673   675   682   688   693   697   711                 |
 |  CENSORED DEATHS                                                               |
 |      11    60                                                                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = 100.    MG/KG                                  |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 25     CENSORED DEATHS 1    TERMINAL 24        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      123   401   403   405   459   504   571   573   590   599                 |
 |      617   620   629   630   635   638   648   650   666   688                 |
 |      688   698   710   713   714                                               |
 |  CENSORED DEATHS                                                               |
 |      661                                                                       |
 |                                                                                |
 ==================================================================================

                                     FURFURAL


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 729 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                          DOSE = 175.    MG/KG                                  |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 17     CENSORED DEATHS 6    TERMINAL 27        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      456   464   467   475   548   563   566   576   632   662                 |
 |      662   682   688   696   724   728   728                                   |
 |  CENSORED DEATHS                                                               |
 |      56    56    57    57    57    224                                         |
 |                                                                                |
 ==================================================================================

                                     FURFURAL


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 729 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   729 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |VEHICLE    |    98.0  96.0  96.0  96.0  94.0  88.0  86.0  84.0  78.0  70.0      |
 |CONTROL    |                                                                    |
 |           |                                                                    |
 |50.        |   100.0 100.0  97.9  97.9  97.9  95.8  89.6  81.3  75.0  58.3      |
 |MG/KG      |                                                                    |
 |           |                                                                    |
 |100.       |   100.0  98.0  98.0  98.0  92.0  90.0  88.0  80.0  64.0  49.5      |
 |MG/KG      |                                                                    |
 |           |                                                                    |
 |175.       |   100.0 100.0 100.0 100.0 100.0  90.9  90.9  81.8  75.0  61.4      |
 |MG/KG      |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                  DOSE                          |
 |                                                                                |
 |                                VEHICLE      50.          100.         175.     |
 |                                CONTROL      MG/KG        MG/KG        MG/KG    |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       70.0%        58.3%        49.5%        61.4%    |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=0.469      P=0.373      P=0.079      P=0.605  |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       509.3        591.6        582.9        606.9    |
 |NATURAL DEATHS (C)      |       (54.3)       (27.3)       (27.2)       (24.1)   |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       663.1        646.3        654.6        610.1    |
 |(STANDARD ERROR)        |       (21.4)       (22.9)       (17.0)       (30.1)   |
 |                        |                                                       |
 ==================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                                     FURFURAL


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 729 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                          DOSE = VEHICLE CONTROL                                |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 16     CENSORED DEATHS 1    TERMINAL 33        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      405   456   473   491   492   543   576   598   620   630                 |
 |      644   648   648   662   671   700                                         |
 |  CENSORED DEATHS                                                               |
 |      11                                                                        |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = 50.     MG/KG                                  |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 20     CENSORED DEATHS 2    TERMINAL 28        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      309   434   435   445   464   473   477   491   492   616                 |
 |      630   634   654   657   679   693   704   710   715   719                 |
 |  CENSORED DEATHS                                                               |
 |      261   374                                                                 |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = 100.    MG/KG                                  |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 21     CENSORED DEATHS 0    TERMINAL 29        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      360   394   438   488   490   493   506   514   523   536                 |
 |      568   574   575   605   611   648   662   675   693   717                 |
 |      719                                                                       |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================

                                     FURFURAL


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 729 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                          DOSE = 175.    MG/KG                                  |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 18     CENSORED DEATHS 0    TERMINAL 32        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      246   382   442   514   526   549   586   596   601   615                 |
 |      615   633   634   643   654   654   662   670                             |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================

                                     FURFURAL


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 729 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   729 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |VEHICLE    |   100.0 100.0 100.0 100.0  98.0  93.9  87.8  83.7  71.4  67.3      |
 |CONTROL    |                                                                    |
 |           |                                                                    |
 |50.        |   100.0 100.0 100.0  98.0  98.0  85.5  81.3  81.3  70.9  58.4      |
 |MG/KG      |                                                                    |
 |           |                                                                    |
 |100.       |   100.0 100.0 100.0  98.0  96.0  94.0  80.0  72.0  66.0  58.0      |
 |MG/KG      |                                                                    |
 |           |                                                                    |
 |175.       |   100.0 100.0  98.0  98.0  96.0  94.0  90.0  82.0  66.0  64.0      |
 |MG/KG      |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                  DOSE                          |
 |                                                                                |
 |                                VEHICLE      50.          100.         175.     |
 |                                CONTROL      MG/KG        MG/KG        MG/KG    |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       67.3%        58.4%        58.0%        64.0%    |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=0.839      P=0.486      P=0.401      P=0.842  |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       578.6        571.6        561.4        567.9    |
 |NATURAL DEATHS (C)      |       (22.5)       (27.8)       (22.3)       (26.4)   |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       666.5        649.6        658.6        671.0    |
 |(STANDARD ERROR)        |       (18.1)       (18.3)       (15.0)       (14.5)   |
 |                        |                                                       |
 ==================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                                                              FURFURAL
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        VEHICLE CONTROL  = 1
                                                        50.     MG/KG    = 2
                                                        100.    MG/KG    = 3
                                                        175.    MG/KG    = 4

------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
  100 + 11                  3            2                                       4
      |
      |  1                  1            2                              3   2    44
      |                     1                                      1        2         2
   95 +
      |                                                            1             144
      |                                                                 3        3
      |                                                                            4  2 2      4
   90 +                                                                          1 1   32        2
      |                                                                                        4 4
      |                                                                            1   3 1       22
      |                                                                                  1         1
P  85 +                                                                                           22
E     |                                                                                          431  2  1
R     |                                                                                               33 11
C     |                                                                                            4  2 2   4
E  80 +                                                                                                3  1 4    1
N     |                                                                                                 2     2
T     |                                                                                                       22 11
      |                                                                                                   33      11
S  75 +                                                                                                        2 42 4
U     |                                                                                                            1   1
R     |                                                                                                    33     2244 1 1
V     |
I  70 +                                                                                                     33       44  1  1
V     |                                                                                                            22 4   4
A     |                                                                                                      33
L     |                                                                                                             22
   65 +
      |                                                                                                       3   3
      |                                                                                                           3  22
      |                                                                                                                   4 4
   60 +                                                                                                               2 2
      |                                                                                                                 2   2
      |                                                                                                              33
      |                                                                                                               3 3
   55 +
      |
      |
      |
   50 +                                                                                                                 3   3
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 12 obs hidden.

                                                              FURFURAL
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        VEHICLE CONTROL  = 1
                                                        50.     MG/KG    = 2
                                                        100.    MG/KG    = 3
                                                        175.    MG/KG    = 4

----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  100 + 1                                       4         2      3      1
      |
      |                                         4         2      3   4 31   2    1
      |                                                              4 3    224  1 1
   95 +
      |                                                                      22    1 31  4
      |                                                                                  4  4
      |                                                                       2   2
   90 +                                                                           22 31     4 14
      |
P     |                                                                            22 3 3     14   14
E     |                                                                                 33         14  1
R  85 +                                                                             2 2
C     |                                                                                  3 3           1  1
E     |                                                                                    3 3         4 4
N     |                                                                               2                  211
T  80 +                                                                                      3    3        1 1
      |                                                                                                  2 2
S     |                                                                                                  4 2211
U     |                                                                                           33
R  75 +                                                                                                     2  2
V     |                                                                                            3    3   441  1
I     |                                                                                                 33   4 4
V     |                                                                                                        2 112
A  70 +                                                                                                  3    3   1   1
L     |                                                                                                            2 2
      |                                                                                                       34 3    1     1
      |                                                                                                          343 2 2
   65 +                                                                                                                22
      |                                                                                                           43 3      4
      |                                                                                                              3  22
      |
   60 +
      |                                                                                                                  2  2
      |                                                                                                                  3  3
      |
   55 +
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 12 obs hidden.

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