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TR 382 Rat Pathology Tables


                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                                              FURFURAL


NTP Experiment-Test: 05005-07                                                                                     Report: PEIRPT03
Study Type: CHRONIC                                                                                               Date: 09/03/94
Route: GAVAGE                                                                                                     Time: 04:58:00




       Facility:  Southern Research Institute

       Chemical CAS #:  98-01-1

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05005-07         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                              FURFURAL                                         Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 04:58:00  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   VEHICLE      30.          60.                                                    
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Dead                                               9            5            4                                                  
    Moribund                                           9           11            9                                                  
    Dosing Accident                                    4            2           19                                                  
  Survivors                                                                                                                         
    Dead                                                                         1                                                  
    Terminal Sacrifice                                28           32           17                                                  
  Animals Examined Microscopically                    50           50           50                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (49)         (50)         (48)                                                
      Parasite Metazoan                                             1 (2%)       1 (2%)                                             
   Intestine Large, Colon                             (49)         (50)         (49)                                                
      Cyst                                                          1 (2%)                                                          
      Parasite Metazoan                                4 (8%)       2 (4%)       2 (4%)                                             
   Intestine Large, Rectum                            (50)         (50)         (47)                                                
      Parasite Metazoan                                3 (6%)       7 (14%)      3 (6%)                                             
   Liver                                              (50)         (50)         (50)                                                
      Angiectasis, Focal                                            2 (4%)       2 (4%)                                             
      Basophilic Focus                                39 (78%)     45 (90%)     40 (80%)                                            
      Clear Cell Focus                                 8 (16%)     10 (20%)     14 (28%)                                            
      Degeneration, Cystic                                          1 (2%)                                                          
      Eosinophilic Focus                                            1 (2%)                                                          
      Fatty Change                                     1 (2%)                                                                       
      Fatty Change, Diffuse                                         2 (4%)       1 (2%)                                             
      Fatty Change, Focal                                           1 (2%)                                                          
      Granuloma, Multiple                             11 (22%)     22 (44%)     13 (26%)                                            
      Hematopoietic Cell Proliferation                              1 (2%)       2 (4%)                                             
      Hepatodiaphragmatic Nodule                       3 (6%)       4 (8%)       5 (10%)                                            
      Hyperplasia, Focal                               2 (4%)       1 (2%)       2 (4%)                                             
      Mixed Cell Focus                                                           2 (4%)                                             
      Necrosis, Focal                                  2 (4%)                    1 (2%)                                             
      Necrosis, Multifocal                                          1 (2%)       1 (2%)                                             
      Vacuolization Cytoplasmic, Focal                              1 (2%)                                                          
      Bile Duct, Hyperplasia                          34 (68%)     28 (56%)     24 (48%)                                            
      Centrilobular, Fatty Change                                   2 (4%)       1 (2%)                                             
      Centrilobular, Necrosis                         10 (20%)      9 (18%)      4 (8%)                                             
      Hepatocyte, Cytomegaly                           1 (2%)                                                                       
   Mesentery                                          (8)          (10)         (11)                                                
      Hemorrhage                                                                 1 (9%)                                             
      Fat, Necrosis, Focal                             6 (75%)     10 (100%)     6 (55%)                                            
   Pancreas                                           (50)         (50)         (48)                                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05005-07         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                              FURFURAL                                         Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 04:58:00  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   VEHICLE      30.          60.                                                    
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Acinus, Atrophy, Focal                           2 (4%)       5 (10%)                                                         
      Acinus, Atrophy, Multifocal                      9 (18%)      6 (12%)      4 (8%)                                             
      Acinus, Basophilic Focus                                      1 (2%)                                                          
      Acinus, Hyperplasia, Focal                                    2 (4%)       1 (2%)                                             
      Acinus, Hyperplasia, Multifocal                               1 (2%)                                                          
      Duct, Ectasia                                    1 (2%)                                                                       
   Salivary Glands                                    (50)         (50)         (49)                                                
      Atrophy, Multifocal                              1 (2%)                                                                       
      Inflammation, Subacute                                        1 (2%)       1 (2%)                                             
   Stomach, Forestomach                               (50)         (50)         (50)                                                
      Erosion                                                                    1 (2%)                                             
      Hyperkeratosis                                                1 (2%)                                                          
      Hyperplasia                                      2 (4%)       4 (8%)       3 (6%)                                             
      Inflammation, Subacute                           2 (4%)       3 (6%)       2 (4%)                                             
      Mineralization                                                             1 (2%)                                             
      Ulcer                                            2 (4%)       4 (8%)                                                          
   Stomach, Glandular                                 (50)         (50)         (50)                                                
      Erosion                                                       1 (2%)       1 (2%)                                             
      Erosion, Multiple                                             1 (2%)                                                          
      Inflammation, Subacute                           1 (2%)       1 (2%)       1 (2%)                                             
      Mineralization                                   9 (18%)      9 (18%)      5 (10%)                                            
      Ulcer                                            1 (2%)       1 (2%)       1 (2%)                                             
   Tongue                                                          (2)                                                              
      Foreign Body                                                  1 (50%)                                                         
      Granuloma                                                     1 (50%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                                    (1)                                                              
      Aorta, Mineralization                                         1 (100%)                                                        
   Heart                                              (50)         (50)         (50)                                                
      Cardiomyopathy                                  16 (32%)     24 (48%)     18 (36%)                                            
      Inflammation, Chronic, Multifocal                             1 (2%)                                                          
      Mineralization, Multifocal                                    1 (2%)                                                          
      Valve, Thrombosis                                                          1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (49)         (50)         (50)                                                
      Focal Cellular Change                            7 (14%)      9 (18%)      5 (10%)                                            
      Hematopoietic Cell Proliferation                                           3 (6%)                                             
      Hyperplasia                                      1 (2%)                                                                       
      Hyperplasia, Focal                                                         2 (4%)                                             
      Hypertrophy, Focal                               1 (2%)                                                                       
      Inflammation, Granulomatous                                   1 (2%)                                                          
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05005-07         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                              FURFURAL                                         Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 04:58:00  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   VEHICLE      30.          60.                                                    
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Mineralization, Multifocal                                    1 (2%)                                                          
      Necrosis, Multifocal                                          1 (2%)                                                          
      Capsule, Accessory Adrenal Cortical Nodule       1 (2%)       5 (10%)      2 (4%)                                             
   Adrenal Gland, Medulla                             (47)         (50)         (50)                                                
      Hyperplasia, Focal                               4 (9%)       5 (10%)      7 (14%)                                            
      Infiltration Cellular, Multifocal, Lymphocyte    1 (2%)                                                                       
   Islets, Pancreatic                                 (50)         (50)         (48)                                                
      Hyperplasia                                      2 (4%)                                                                       
      Hyperplasia, Focal                                                         1 (2%)                                             
   Parathyroid Gland                                  (48)         (48)         (48)                                                
      Hyperplasia                                                   1 (2%)                                                          
   Pituitary Gland                                    (49)         (50)         (50)                                                
      Hyperplasia, Focal                                                         1 (2%)                                             
      Pars Distalis, Angiectasis                      27 (55%)     30 (60%)     19 (38%)                                            
      Pars Distalis, Cyst                             24 (49%)     16 (32%)     22 (44%)                                            
      Pars Distalis, Hyperplasia                       1 (2%)       1 (2%)       1 (2%)                                             
      Pars Distalis, Hyperplasia, Focal               12 (24%)     10 (20%)     17 (34%)                                            
      Pars Distalis, Pigmentation, Hemosiderin        18 (37%)     22 (44%)      7 (14%)                                            
   Thyroid Gland                                      (50)         (50)         (50)                                                
      Ultimobranchial Cyst                             1 (2%)       1 (2%)       1 (2%)                                             
      C-Cell, Hyperplasia, Focal                      11 (22%)     15 (30%)     11 (22%)                                            
      Follicle, Cyst                                   1 (2%)       3 (6%)       1 (2%)                                             
      Follicular Cell, Hyperplasia                     1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (50)         (49)         (47)                                                
      Inflammation, Acute, Suppurative                 2 (4%)       2 (4%)                                                          
      Inflammation, Subacute                           1 (2%)       3 (6%)       1 (2%)                                             
      Duct, Cyst                                       3 (6%)       5 (10%)      1 (2%)                                             
      Duct, Cyst, Multiple                                          1 (2%)                                                          
   Ovary                                              (50)         (50)         (50)                                                
      Cyst                                             7 (14%)      8 (16%)      7 (14%)                                            
      Inflammation, Chronic                                                      1 (2%)                                             
      Inflammation, Granulomatous                                   1 (2%)                                                          
   Uterus                                             (50)         (50)         (49)                                                
      Cyst                                             1 (2%)       1 (2%)       1 (2%)                                             
      Fibrosis                                                      1 (2%)                                                          
      Hemorrhage                                                    1 (2%)       2 (4%)                                             
      Hydrometra                                       1 (2%)                    1 (2%)                                             
      Hyperplasia, Cystic                              1 (2%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05005-07         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                              FURFURAL                                         Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 04:58:00  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   VEHICLE      30.          60.                                                    
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Neovascularization                                            1 (2%)                                                          
      Pigmentation, Hemosiderin                                     1 (2%)                                                          
      Prolapse                                                                   1 (2%)                                             
      Cervix, Abscess                                  1 (2%)                    1 (2%)                                             
      Cervix, Cyst                                     1 (2%)                    1 (2%)                                             
      Cervix, Hypertrophy                                           2 (4%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Blood                                                           (1)          (2)                                                 
      Anemia                                                                     1 (50%)                                            
      Polychromasia                                                              1 (50%)                                            
   Bone Marrow                                        (50)         (47)         (50)                                                
      Hyperplasia                                      3 (6%)       6 (13%)      2 (4%)                                             
   Lymph Node, Mandibular                             (50)         (50)         (49)                                                
      Ectasia                                          3 (6%)       3 (6%)       2 (4%)                                             
   Spleen                                             (50)         (50)         (50)                                                
      Atrophy                                                       4 (8%)                                                          
      Fibrosis, Focal                                  1 (2%)                                                                       
      Hematopoietic Cell Proliferation                 4 (8%)       6 (12%)      4 (8%)                                             
      Hemorrhage, Focal                                1 (2%)                                                                       
      Hyperplasia, Lymphoid                            1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (49)         (50)         (50)                                                
      Galactocele                                      1 (2%)                    1 (2%)                                             
      Duct, Cyst                                      44 (90%)     39 (78%)     29 (58%)                                            
      Duct, Inflammation, Acute, Suppurative           1 (2%)                                                                       
   Skin                                               (50)         (50)         (50)                                                
      Cyst Epithelial Inclusion                        1 (2%)                                                                       
      Inflammation, Focal, Subacute                    1 (2%)                                                                       
      Subcutaneous Tissue, Abscess                                  1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)                                                
      Fibrous Osteodystrophy                                        1 (2%)                                                          
      Cranium, Osteopetrosis                           1 (2%)       2 (4%)       2 (4%)                                             
      Femur, Osteopetrosis                                          3 (6%)       3 (6%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05005-07         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                              FURFURAL                                         Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 04:58:00  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   VEHICLE      30.          60.                                                    
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (49)                                                
      Compression                                      7 (14%)      8 (16%)      3 (6%)                                             
      Hemorrhage, Multifocal                           2 (4%)                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)                                                
      Congestion                                       6 (12%)      6 (12%)     23 (46%)                                            
      Foreign Body                                     5 (10%)      4 (8%)      19 (38%)                                            
      Granuloma, Multiple                             16 (32%)     15 (30%)      5 (10%)                                            
      Hemorrhage, Multifocal                                        1 (2%)                                                          
      Infiltration Cellular, Multifocal, Histiocyte    6 (12%)      6 (12%)      1 (2%)                                             
      Mineralization                                                1 (2%)                                                          
      Pigmentation, Multifocal, Cholesterol            4 (8%)       2 (4%)                                                          
      Alveolar Epithelium, Hyperplasia, Focal                       1 (2%)                                                          
   Nose                                               (50)         (50)         (50)                                                
      Fungus                                                        1 (2%)                                                          
      Inflammation, Acute, Suppurative                              2 (4%)                                                          
      Nasolacrimal Duct, Cyst                                       1 (2%)                                                          
      Nasolacrimal Duct, Foreign Body                  1 (2%)       1 (2%)                                                          
      Nasolacrimal Duct, Inflammation, Acute,                                                                                       
          Suppurative                                  2 (4%)       2 (4%)                                                          
      Nasolacrimal Duct, Inflammation, Subacute        8 (16%)     12 (24%)      6 (12%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (3)          (4)          (2)                                                 
      Cataract                                         2 (67%)      4 (100%)     2 (100%)                                           
      Hemorrhage                                       1 (33%)                                                                      
      Retina, Degeneration                             2 (67%)      4 (100%)     2 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)                                                
      Hydronephrosis                                                1 (2%)                                                          
      Nephropathy, Chronic                            28 (56%)     39 (78%)     29 (58%)                                            
      Cortex, Cyst                                                  1 (2%)       1 (2%)                                             
      Medulla, Inflammation, Acute, Suppurative        1 (2%)                                                                       
      Papilla, Necrosis                                1 (2%)                                                                       
      Renal Tubule, Dilatation, Multifocal                          1 (2%)                                                          
      Renal Tubule, Mineralization, Focal                           1 (2%)                                                          
      Renal Tubule, Mineralization, Multifocal         1 (2%)       1 (2%)                                                          
   Urinary Bladder                                    (49)         (50)         (48)                                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05005-07         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                              FURFURAL                                         Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 04:58:00  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   VEHICLE      30.          60.                                                    
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Inflammation, Acute, Suppurative                 1 (2%)                                                                       
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 05005-07         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                              FURFURAL                                         Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 04:58:00  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     VEHICLE      30.          60.                                                    
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Dosing Accident                                    6            7            8                                                  
    Moribund                                          11           11           11                                                  
    Dead                                               2            4            7                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                31           28           24                                                  
  Animals Examined Microscopically                    50           50           50                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (50)         (50)         (48)                                                
      Parasite Metazoan                                3 (6%)       1 (2%)       2 (4%)                                             
   Intestine Large, Colon                             (50)         (49)         (48)                                                
      Parasite Metazoan                                6 (12%)      5 (10%)      7 (15%)                                            
   Intestine Large, Rectum                            (49)         (49)         (45)                                                
      Parasite Metazoan                                7 (14%)      6 (12%)     10 (22%)                                            
   Intestine Small, Duodenum                          (48)         (48)         (47)                                                
      Erosion, Multiple                                             1 (2%)                                                          
      Intussusception                                               1 (2%)                                                          
   Liver                                              (50)         (50)         (50)                                                
      Angiectasis, Focal                                            1 (2%)       1 (2%)                                             
      Angiectasis, Multifocal                          1 (2%)                                                                       
      Basophilic Focus                                37 (74%)     35 (70%)     26 (52%)                                            
      Clear Cell Focus                                21 (42%)     19 (38%)     16 (32%)                                            
      Congestion                                                                 1 (2%)                                             
      Degeneration, Cystic                             5 (10%)     11 (22%)      2 (4%)                                             
      Degeneration, Cystic, Focal                      1 (2%)                    6 (12%)                                            
      Fatty Change, Diffuse                                         2 (4%)       2 (4%)                                             
      Granuloma, Multiple                              2 (4%)       7 (14%)      3 (6%)                                             
      Hematopoietic Cell Proliferation                              1 (2%)                                                          
      Hepatodiaphragmatic Nodule                       4 (8%)       5 (10%)      1 (2%)                                             
      Hyperplasia, Focal                                            1 (2%)                                                          
      Necrosis, Multifocal                                          1 (2%)                                                          
      Bile Duct, Dysplasia, Focal                                                2 (4%)                                             
      Bile Duct, Fibrosis, Focal                                                 2 (4%)                                             
      Bile Duct, Hyperplasia                          45 (90%)     41 (82%)     42 (84%)                                            
      Bile Duct, Hyperplasia, Focal                                              1 (2%)                                             
      Biliary Tract, Cyst Multilocular                                           1 (2%)                                             
      Centrilobular, Fatty Change                     10 (20%)      6 (12%)      3 (6%)                                             
      Centrilobular, Necrosis                          2 (4%)       8 (16%)     12 (24%)                                            
      Centrilobular, Necrosis, Focal                                1 (2%)                                                          
      Centrilobular, Necrosis, Multifocal              1 (2%)                                                                       
   Mesentery                                          (5)          (8)          (9)                                                 
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
NTP Experiment-Test: 05005-07         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                              FURFURAL                                         Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 04:58:00  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     VEHICLE      30.          60.                                                    
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Fat, Necrosis, Focal                             3 (60%)      4 (50%)      6 (67%)                                            
   Pancreas                                           (50)         (50)         (47)                                                
      Inflammation, Chronic, Multifocal                             1 (2%)                                                          
      Inflammation, Multifocal, Subacute                            1 (2%)                                                          
      Acinus, Atrophy, Focal                           6 (12%)      6 (12%)      4 (9%)                                             
      Acinus, Atrophy, Multifocal                     13 (26%)      8 (16%)     12 (26%)                                            
      Acinus, Hyperplasia, Focal                      10 (20%)     18 (36%)     16 (34%)                                            
      Acinus, Hyperplasia, Multifocal                  1 (2%)       5 (10%)                                                         
      Artery, Hypertrophy                                           2 (4%)                                                          
      Artery, Inflammation, Subacute                                1 (2%)                                                          
      Artery, Mineralization                                        1 (2%)                                                          
      Duct, Ectasia                                                              1 (2%)                                             
   Stomach, Forestomach                               (50)         (50)         (50)                                                
      Edema                                                         2 (4%)                                                          
      Erosion                                          1 (2%)       1 (2%)                                                          
      Hyperplasia                                      1 (2%)       5 (10%)      2 (4%)                                             
      Inflammation, Subacute                           2 (4%)       5 (10%)      2 (4%)                                             
      Perforation                                                   2 (4%)                                                          
      Ulcer                                                         1 (2%)       1 (2%)                                             
      Ulcer, Multiple                                  1 (2%)                                                                       
   Stomach, Glandular                                 (50)         (50)         (50)                                                
      Erosion                                          1 (2%)                    1 (2%)                                             
      Inflammation, Subacute                                        2 (4%)                                                          
      Mineralization                                   5 (10%)     11 (22%)      6 (12%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                                                 (2)                                                 
      Aorta, Mineralization                                                      2 (100%)                                           
   Heart                                              (50)         (50)         (50)                                                
      Cardiomyopathy                                  35 (70%)     32 (64%)     36 (72%)                                            
      Congestion                                                                 1 (2%)                                             
      Inflammation, Chronic, Focal                                  1 (2%)       1 (2%)                                             
      Mineralization, Multifocal                                    1 (2%)                                                          
      Thrombosis                                       1 (2%)       1 (2%)       2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (50)         (47)                                                
      Focal Cellular Change                            6 (12%)      5 (10%)      3 (6%)                                             
      Focal Cellular Change, Multiple                               1 (2%)                                                          
      Hematopoietic Cell Proliferation                 2 (4%)                    1 (2%)                                             
      Hemorrhage, Focal                                                          1 (2%)                                             
      Hyperplasia, Focal                               1 (2%)                                                                       
      Hypertrophy, Focal                               1 (2%)                    1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    9                                                              
NTP Experiment-Test: 05005-07         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                              FURFURAL                                         Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 04:58:00  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     VEHICLE      30.          60.                                                    
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Capsule, Accessory Adrenal Cortical Nodule       2 (4%)       4 (8%)                                                          
   Adrenal Gland, Medulla                             (50)         (49)         (46)                                                
      Hemorrhage                                                    2 (4%)                                                          
      Hyperplasia, Focal                               6 (12%)     14 (29%)      8 (17%)                                            
      Pigmentation, Hemosiderin                                     2 (4%)                                                          
   Islets, Pancreatic                                 (50)         (50)         (47)                                                
      Hyperplasia                                                   1 (2%)       1 (2%)                                             
      Hyperplasia, Focal                               5 (10%)                   1 (2%)                                             
   Parathyroid Gland                                  (49)         (48)         (47)                                                
      Hyperplasia                                      3 (6%)       4 (8%)       3 (6%)                                             
   Pituitary Gland                                    (50)         (49)         (50)                                                
      Pars Distalis, Angiectasis                      16 (32%)     20 (41%)     17 (34%)                                            
      Pars Distalis, Cyst                              3 (6%)       4 (8%)       2 (4%)                                             
      Pars Distalis, Hemorrhage                        1 (2%)                                                                       
      Pars Distalis, Hyperplasia, Focal               13 (26%)      9 (18%)     12 (24%)                                            
      Pars Distalis, Pigmentation, Hematoidin                       2 (4%)                                                          
      Pars Distalis, Pigmentation, Hemosiderin         5 (10%)     14 (29%)      6 (12%)                                            
      Pars Nervosa, Cyst                                            1 (2%)                                                          
   Thyroid Gland                                      (50)         (50)         (50)                                                
      Ultimobranchial Cyst                             1 (2%)                                                                       
      C-Cell, Hyperplasia, Focal                       3 (6%)       7 (14%)      4 (8%)                                             
      C-Cell, Hyperplasia, Multifocal                  1 (2%)       2 (4%)                                                          
      Follicle, Cyst                                   1 (2%)       5 (10%)      2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Coagulating Gland                                               (1)                                                              
      Inflammation, Subacute                                        1 (100%)                                                        
   Epididymis                                         (50)         (50)         (50)                                                
      Inflammation, Subacute                           1 (2%)                                                                       
   Preputial Gland                                    (49)         (50)         (47)                                                
      Foreign Body                                     1 (2%)                                                                       
      Inflammation, Acute, Suppurative                 1 (2%)                                                                       
      Inflammation, Focal, Granulomatous               1 (2%)                                                                       
      Inflammation, Granulomatous                      4 (8%)                    3 (6%)                                             
      Inflammation, Subacute                           6 (12%)     11 (22%)      5 (11%)                                            
      Duct, Cyst                                       1 (2%)       5 (10%)      1 (2%)                                             
   Prostate                                           (50)         (50)         (50)                                                
      Inflammation, Acute, Suppurative                              1 (2%)                                                          
      Inflammation, Subacute                          23 (46%)     19 (38%)     18 (36%)                                            
   Seminal Vesicle                                    (47)         (50)         (50)                                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   10                                                              
NTP Experiment-Test: 05005-07         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                              FURFURAL                                         Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 04:58:00  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     VEHICLE      30.          60.                                                    
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Dilatation                                       1 (2%)                    1 (2%)                                             
      Inflammation, Acute, Suppurative                 1 (2%)                                                                       
      Inflammation, Chronic                                         1 (2%)                                                          
      Inflammation, Subacute                                                     1 (2%)                                             
   Testes                                             (50)         (50)         (50)                                                
      Atrophy                                          6 (12%)      3 (6%)      11 (22%)                                            
      Developmental Malformation                       1 (2%)                                                                       
      Mineralization                                                3 (6%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Blood                                              (2)                                                                           
      Anemia                                           2 (100%)                                                                     
   Bone Marrow                                        (50)         (50)         (50)                                                
      Hyperplasia                                      5 (10%)      4 (8%)       4 (8%)                                             
   Lymph Node                                         (50)         (50)         (48)                                                
      Deep Cervical, Ectasia                                        1 (2%)                                                          
      Deep Cervical, Hyperplasia                                    1 (2%)                                                          
      Inguinal, Ectasia                                1 (2%)                                                                       
      Inguinal, Inflammation, Acute, Suppurative       1 (2%)                                                                       
      Mediastinal, Congestion                          1 (2%)       1 (2%)       2 (4%)                                             
      Mediastinal, Ectasia                                                       2 (4%)                                             
      Mediastinal, Pigmentation, Hemosiderin                                     1 (2%)                                             
      Pancreatic, Ectasia                              1 (2%)                    1 (2%)                                             
   Lymph Node, Mandibular                             (49)         (49)         (47)                                                
      Ectasia                                          9 (18%)      6 (12%)      6 (13%)                                            
      Hyperplasia                                      1 (2%)                    1 (2%)                                             
   Lymph Node, Mesenteric                             (48)         (49)         (46)                                                
      Congestion                                       2 (4%)                                                                       
   Spleen                                             (50)         (50)         (49)                                                
      Fibrosis, Focal                                  1 (2%)       1 (2%)       1 (2%)                                             
      Hematopoietic Cell Proliferation                 9 (18%)      5 (10%)      5 (10%)                                            
      Hemorrhage                                       1 (2%)                                                                       
      Necrosis, Focal                                               1 (2%)                                                          
      Necrosis, Multifocal                                          1 (2%)       1 (2%)                                             
      Thrombosis                                                                 1 (2%)                                             
   Thymus                                             (43)         (48)         (38)                                                
      Cyst                                                          1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (45)         (49)         (47)                                                
      Duct, Cyst                                      21 (47%)     27 (55%)     24 (51%)                                            
   Skin                                               (50)         (50)         (49)                                                
      Inflammation, Acute, Focal, Suppurative                       1 (2%)                                                          
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   11                                                              
NTP Experiment-Test: 05005-07         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                              FURFURAL                                         Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 04:58:00  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     VEHICLE      30.          60.                                                    
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)                                                
      Fibrous Osteodystrophy                                        4 (8%)       2 (4%)                                             
   Skeletal Muscle                                    (1)                       (2)                                                 
      Inflammation, Granulomatous, Multifocal                                    1 (50%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)                                                
      Compression                                      4 (8%)       2 (4%)       3 (6%)                                             
      Fungus                                                                     1 (2%)                                             
      Hemorrhage, Multifocal                           1 (2%)       1 (2%)       2 (4%)                                             
      Hydrocephalus                                    1 (2%)                                                                       
      Inflammation, Acute, Suppurative                                           1 (2%)                                             
      Necrosis                                                                   1 (2%)                                             
      Thrombosis, Multiple                                                       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)                                                
      Congestion                                       7 (14%)      9 (18%)      9 (18%)                                            
      Foreign Body                                     7 (14%)      8 (16%)      8 (16%)                                            
      Fungus                                                                     1 (2%)                                             
      Granuloma, Multiple                              6 (12%)      2 (4%)                                                          
      Hemorrhage, Multifocal                                        1 (2%)                                                          
      Infiltration Cellular, Multifocal, Histiocyte    1 (2%)       2 (4%)       1 (2%)                                             
      Inflammation, Acute, Focal, Suppurative                                    2 (4%)                                             
      Necrosis, Multifocal                                          1 (2%)       1 (2%)                                             
      Pigmentation, Multifocal                                      1 (2%)                                                          
      Thrombosis, Multiple                                                       1 (2%)                                             
      Alveolar Epithelium, Hyperplasia, Focal          1 (2%)                    3 (6%)                                             
      Alveolar Epithelium, Hyperplasia, Multifocal                  1 (2%)                                                          
      Fat, Mediastinum, Necrosis, Multifocal                        1 (2%)                                                          
      Mediastinum, Foreign Body                                     1 (2%)       1 (2%)                                             
      Pleura, Fibrosis, Focal                                       1 (2%)                                                          
   Nose                                               (50)         (49)         (50)                                                
      Foreign Body                                     4 (8%)      10 (20%)      4 (8%)                                             
      Fungus                                          13 (26%)     10 (20%)     10 (20%)                                            
      Inflammation, Acute, Suppurative                13 (26%)     13 (27%)     10 (20%)                                            
      Mucosa, Hyperkeratosis, Focal                    1 (2%)                                                                       
      Mucosa, Hyperplasia, Focal                       1 (2%)                                                                       
      Nasolacrimal Duct, Cyst                                                    1 (2%)                                             
      Nasolacrimal Duct, Foreign Body                  1 (2%)       2 (4%)       1 (2%)                                             
      Nasolacrimal Duct, Inflammation, Acute,                                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   12                                                              
NTP Experiment-Test: 05005-07         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                              FURFURAL                                         Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 04:58:00  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     VEHICLE      30.          60.                                                    
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
          Suppurative                                  5 (10%)      1 (2%)                                                          
      Nasolacrimal Duct, Inflammation, Subacute        4 (8%)      10 (20%)      5 (10%)                                            
      Nasopharyngeal Duct, Cyst                                     1 (2%)                                                          
      Nasopharyngeal Duct, Foreign Body                                          1 (2%)                                             
      Nasopharyngeal Duct, Inflammation, Subacute                   1 (2%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (4)          (2)          (3)                                                 
      Cataract                                         2 (50%)      2 (100%)     3 (100%)                                           
      Retina, Degeneration                             3 (75%)      2 (100%)     3 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)                                                
      Developmental Malformation                                    1 (2%)                                                          
      Hydronephrosis                                                1 (2%)       1 (2%)                                             
      Inflammation, Acute, Multifocal, Suppurative                  1 (2%)                                                          
      Nephropathy, Chronic                            42 (84%)     43 (86%)     43 (86%)                                            
      Capsule, Fibrosis, Focal                                      1 (2%)                                                          
      Cortex, Cyst                                     3 (6%)       3 (6%)                                                          
      Papilla, Necrosis                                             1 (2%)                                                          
      Pelvis, Inflammation, Acute, Suppurative                      1 (2%)                                                          
      Renal Tubule, Dilatation, Multifocal                          1 (2%)                                                          
      Renal Tubule, Mineralization, Multifocal                      1 (2%)                                                          
      Renal Tubule, Pigmentation, Hemosiderin,                                                                                      
           Multifocal                                               1 (2%)       1 (2%)                                             
   Urinary Bladder                                    (50)         (50)         (49)                                                
      Hemorrhage                                                                 1 (2%)                                             
      Inflammation, Acute, Suppurative                              1 (2%)                                                          
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   13                                                              
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