National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/3108

TR 382 Rat Pathology Tables


                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                              FURFURAL


NTP Experiment-Test: 05005-07                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 09/03/94
Route: GAVAGE                                                                                                     Time: 04:58:00




       Facility:  Southern Research Institute

       Chemical CAS #:  98-01-1

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05005-07  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                              FURFURAL                                         Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 04:58:00  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   VEHICLE      30.          60.                                                    
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Dead                                               9            5            4                                                  
    Moribund                                           9           11            9                                                  
    Dosing Accident                                    4            2           19                                                  
  Survivors                                                                                                                         
    Dead                                                                         1                                                  
    Terminal Sacrifice                                28           32           17                                                  
  Animals Examined Microscopically                    50           50           50                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (49)         (50)         (49)                                                
      Sarcoma Stromal, Metastatic, Uterus                           1 (2%)                                                          
   Liver                                              (50)         (50)         (50)                                                
   Mesentery                                          (8)          (10)         (11)                                                
      Sarcoma                                          1 (13%)                                                                      
   Pancreas                                           (50)         (50)         (48)                                                
      Acinus, Adenoma                                                            1 (2%)                                             
   Pharynx                                                         (1)                                                              
      Squamous Cell Papilloma                                       1 (100%)                                                        
   Stomach, Forestomach                               (50)         (50)         (50)                                                
      Squamous Cell Papilloma                                       1 (2%)       1 (2%)                                             
   Stomach, Glandular                                 (50)         (50)         (50)                                                
   Tongue                                                          (2)                                                              
      Squamous Cell Papilloma                                       1 (50%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (49)         (50)         (50)                                                
      Adenoma                                                       1 (2%)                                                          
   Adrenal Gland, Medulla                             (47)         (50)         (50)                                                
      Pheochromocytoma Malignant                       1 (2%)                    1 (2%)                                             
      Pheochromocytoma Complex                                      1 (2%)       1 (2%)                                             
      Pheochromocytoma Benign                          2 (4%)       1 (2%)                                                          
   Islets, Pancreatic                                 (50)         (50)         (48)                                                
      Adenoma                                                       1 (2%)       1 (2%)                                             
                                                             Page   2                                                               
NTP Experiment-Test: 05005-07  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                              FURFURAL                                         Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 04:58:00  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   VEHICLE      30.          60.                                                    
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - cont                                                                                                             
   Pituitary Gland                                    (49)         (50)         (50)                                                
      Pars Distalis, Adenoma                          23 (47%)     28 (56%)     12 (24%)                                            
   Thyroid Gland                                      (50)         (50)         (50)                                                
      C-Cell, Adenoma                                  4 (8%)       2 (4%)       1 (2%)                                             
      C-Cell, Carcinoma                                             1 (2%)                                                          
      Follicular Cell, Adenoma                                                   1 (2%)                                             
      Follicular Cell, Carcinoma                       1 (2%)       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (50)         (49)         (47)                                                
      Adenoma                                          2 (4%)       4 (8%)       1 (2%)                                             
      Carcinoma                                        2 (4%)       1 (2%)       2 (4%)                                             
   Ovary                                              (50)         (50)         (50)                                                
      Granulosa Cell Tumor Malignant                   1 (2%)                                                                       
   Uterus                                             (50)         (50)         (49)                                                
      Adenoma                                                       1 (2%)                                                          
      Hemangioma                                                                 1 (2%)                                             
      Polyp                                                         1 (2%)                                                          
      Polyp Stromal                                   10 (20%)      8 (16%)     13 (27%)                                            
      Polyp Stromal, Multiple                          2 (4%)                    1 (2%)                                             
      Sarcoma Stromal                                  2 (4%)                                                                       
      Cervix, Sarcoma Stromal                                       2 (4%)                                                          
   Vagina                                                          (1)                                                              
      Polyp                                                         1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Blood                                                           (1)          (2)                                                 
   Bone Marrow                                        (50)         (47)         (50)                                                
   Lymph Node                                         (50)         (50)         (49)                                                
   Lymph Node, Mandibular                             (50)         (50)         (49)                                                
   Lymph Node, Mesenteric                             (49)         (50)         (49)                                                
   Spleen                                             (50)         (50)         (50)                                                
   Thymus                                             (47)         (48)         (49)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   3                                                               
NTP Experiment-Test: 05005-07  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                              FURFURAL                                         Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 04:58:00  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   VEHICLE      30.          60.                                                    
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (49)         (50)         (50)                                                
      Adenocarcinoma                                   2 (4%)       3 (6%)       1 (2%)                                             
      Fibroadenoma                                    10 (20%)     10 (20%)     11 (22%)                                            
      Fibroadenoma, Multiple                           2 (4%)       4 (8%)       5 (10%)                                            
   Skin                                               (50)         (50)         (50)                                                
      Subcutaneous Tissue, Fibrosarcoma                             1 (2%)                                                          
      Subcutaneous Tissue, Lipoma                                                1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)                                                
      Cranium, Fibrosarcoma, Metastatic, Skin                       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (49)                                                
      Glioma Malignant                                 1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)                                                
      Alveolar/Bronchiolar Adenoma                                  1 (2%)                                                          
      Alveolar/Bronchiolar Carcinoma                                1 (2%)                                                          
      Mediastinum, Schwannoma Malignant                             1 (2%)                                                          
   Nose                                               (50)         (50)         (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)                                                
      Cortex, Adenoma                                  1 (2%)                                                                       
   Urinary Bladder                                    (49)         (50)         (48)                                                
      Sarcoma Stromal, Metastatic, Uterus                           1 (2%)                                                          
                                                                                                                                    
                                                             Page   4                                                               
NTP Experiment-Test: 05005-07  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                              FURFURAL                                         Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 04:58:00  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   VEHICLE      30.          60.                                                    
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)                                                
      Leukemia Mononuclear                            18 (36%)     15 (30%)      8 (16%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   5                                                               
NTP Experiment-Test: 05005-07  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                              FURFURAL                                         Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 04:58:00  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   VEHICLE      30.          60.                                                    
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            43          44          33                                                   
     Total Primary Neoplasms                           85          93          63                                                   
                                                                                                                                    
   Total Animals with Benign Neoplasms                 36          38          32                                                   
     Total Benign Neoplasms                            56          66          50                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms              24          24           9                                                   
     Total Malignant Neoplasms                         29          27          13                                                   
                                                                                                                                    
   Total Animals with Metastatic Neoplasms                          2                                                               
     Total Metastatic Neoplasm                                      3                                                               
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   6                                                               
NTP Experiment-Test: 05005-07  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                              FURFURAL                                         Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 04:58:00  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     VEHICLE      30.          60.                                                    
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Dosing Accident                                    6            7            8                                                  
    Moribund                                          11           11           11                                                  
    Dead                                               2            4            7                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                31           28           24                                                  
  Animals Examined Microscopically                    50           50           50                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Small, Jejunum                           (49)         (49)         (47)                                                
      Fibrosarcoma                                     1 (2%)                                                                       
      Polyp Adenomatous                                             1 (2%)                                                          
   Liver                                              (50)         (50)         (50)                                                
      Cholangiocarcinoma                                                         2 (4%)                                             
      Chordoma, Metastatic, Uncertain Primary Site                               1 (2%)                                             
      Hepatocellular Adenoma                           1 (2%)                                                                       
   Mesentery                                          (5)          (8)          (9)                                                 
      Sarcoma                                                                    2 (22%)                                            
   Pancreas                                           (50)         (50)         (47)                                                
      Acinus, Adenoma                                  2 (4%)       3 (6%)       2 (4%)                                             
      Acinus, Adenoma, Multiple                        1 (2%)                                                                       
   Stomach, Forestomach                               (50)         (50)         (50)                                                
      Leiomyosarcoma                                                1 (2%)                                                          
      Squamous Cell Carcinoma                                       1 (2%)                                                          
      Squamous Cell Papilloma                                                    2 (4%)                                             
   Stomach, Glandular                                 (50)         (50)         (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)                                                
      Chordoma, Metastatic, Uncertain Primary Site                               1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (50)         (47)                                                
   Adrenal Gland, Medulla                             (50)         (49)         (46)                                                
      Pheochromocytoma Malignant                       2 (4%)       2 (4%)       1 (2%)                                             
      Pheochromocytoma Malignant, Multiple                          1 (2%)                                                          
      Pheochromocytoma Benign                          9 (18%)     12 (24%)      4 (9%)                                             
                                                             Page   7                                                               
NTP Experiment-Test: 05005-07  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                              FURFURAL                                         Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 04:58:00  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     VEHICLE      30.          60.                                                    
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - cont                                                                                                             
      Pheochromocytoma Benign, Multiple                2 (4%)       1 (2%)       1 (2%)                                             
   Islets, Pancreatic                                 (50)         (50)         (47)                                                
      Adenoma                                          4 (8%)       5 (10%)      2 (4%)                                             
      Carcinoma                                        1 (2%)       1 (2%)       2 (4%)                                             
   Pituitary Gland                                    (50)         (49)         (50)                                                
      Pars Distalis, Adenoma                          19 (38%)     18 (37%)     15 (30%)                                            
   Thyroid Gland                                      (50)         (50)         (50)                                                
      C-Cell, Adenoma                                  3 (6%)       2 (4%)       2 (4%)                                             
      C-Cell, Adenoma, Multiple                        1 (2%)                                                                       
      C-Cell, Carcinoma                                1 (2%)                                                                       
      Follicular Cell, Carcinoma                       1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (50)         (50)                                                
   Preputial Gland                                    (49)         (50)         (47)                                                
      Adenoma                                          1 (2%)       4 (8%)       2 (4%)                                             
      Carcinoma                                        1 (2%)       1 (2%)       1 (2%)                                             
   Prostate                                           (50)         (50)         (50)                                                
   Seminal Vesicle                                    (47)         (50)         (50)                                                
   Testes                                             (50)         (50)         (50)                                                
      Interstitial Cell, Adenoma                       2 (4%)       9 (18%)      4 (8%)                                             
      Interstitial Cell, Adenoma, Multiple            36 (72%)     35 (70%)     35 (70%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)                                                
   Lymph Node                                         (50)         (50)         (48)                                                
   Lymph Node, Mandibular                             (49)         (49)         (47)                                                
   Lymph Node, Mesenteric                             (48)         (49)         (46)                                                
   Spleen                                             (50)         (50)         (49)                                                
      Sarcoma                                                                    1 (2%)                                             
   Thymus                                             (43)         (48)         (38)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   8                                                               
NTP Experiment-Test: 05005-07  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                              FURFURAL                                         Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 04:58:00  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     VEHICLE      30.          60.                                                    
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (45)         (49)         (47)                                                
      Adenocarcinoma                                                1 (2%)                                                          
      Fibroadenoma                                                  1 (2%)       1 (2%)                                             
      Fibroadenoma, Multiple                           1 (2%)                                                                       
   Skin                                               (50)         (50)         (49)                                                
      Basal Cell Carcinoma                             2 (4%)                                                                       
      Keratoacanthoma                                  2 (4%)       1 (2%)       4 (8%)                                             
      Squamous Cell Carcinoma                          1 (2%)                                                                       
      Squamous Cell Papilloma                          1 (2%)       1 (2%)                                                          
      Sebaceous Gland, Adenoma                         1 (2%)                                                                       
      Subcutaneous Tissue, Fibroma                     4 (8%)       5 (10%)      2 (4%)                                             
      Subcutaneous Tissue, Fibroma, Multiple           1 (2%)                                                                       
      Subcutaneous Tissue, Fibrosarcoma                             2 (4%)       1 (2%)                                             
      Subcutaneous Tissue, Lipoma                                   1 (2%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)                                                
      Osteosarcoma                                                  1 (2%)                                                          
   Skeletal Muscle                                    (1)                       (2)                                                 
      Chordoma, Metastatic, Uncertain Primary Site                               1 (50%)                                            
      Fibrosarcoma                                     1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)                                                
      Astrocytoma Malignant                                         1 (2%)                                                          
      Granular Cell Tumor Benign                                    1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)                                                
      Alveolar/Bronchiolar Adenoma                                               1 (2%)                                             
      Basal Cell Carcinoma, Metastatic, Skin           1 (2%)                                                                       
      Chordoma, Metastatic, Uncertain Primary Site                               1 (2%)                                             
   Nose                                               (50)         (49)         (50)                                                
      Papilloma                                                     1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   9                                                               
NTP Experiment-Test: 05005-07  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                              FURFURAL                                         Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 04:58:00  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     VEHICLE      30.          60.                                                    
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                (1)          (1)          (1)                                                 
      Pinna, Schwannoma Benign                         1 (100%)                  1 (100%)                                           
   Zymbal's Gland                                     (3)                                                                           
      Adenoma                                          2 (67%)                                                                      
      Carcinoma                                        1 (33%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)                                                
   Urinary Bladder                                    (50)         (50)         (49)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)                                                
      Leukemia Mononuclear                            13 (26%)     15 (30%)     15 (30%)                                            
      Mesothelioma Malignant                           3 (6%)       3 (6%)       2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  10                                                               
NTP Experiment-Test: 05005-07  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                              FURFURAL                                         Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 04:58:00  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     VEHICLE      30.          60.                                                    
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            47          46          44                                                   
     Total Primary Neoplasms                          122         131         106                                                   
                                                                                                                                    
   Total Animals with Benign Neoplasms                 47          46          43                                                   
     Total Benign Neoplasms                            94         101          79                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms              23          24          26                                                   
     Total Malignant Neoplasms                         28          30          27                                                   
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              2                       1                                                   
     Total Metastatic Neoplasm                          4                       4                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                       1                                                   
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  11                                                               
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