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TR 382 Rat Pathology Tables

NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Southern Research Inst                                     FURFURAL                                       DATE: 09/03/94       
EXPERIMENT: 05005 TEST: 07                                                                                     TIME: 05:09:48       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: NO1CP9565101          ROUTE: GAVAGE                                                                      NTP C#: 56177        
PATHOLOGIST: H. GILES                        S. EUSTIS                                                         CAS: 98-01-1         
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               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08    
LAB: Southern Research Inst                                     FURFURAL                                       DATE: 09/03/94      
EXPERIMENT: 05005 TEST: 07                                                                                     TIME: 05:09:48      
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                       
CONT: NO1CP9565101          ROUTE: GAVAGE                                                                      NTP C#: 56177       
PATHOLOGIST: H. GILES                        S. EUSTIS                                                         CAS: 98-01-1        
 
 
 
 
 
                                                    RATS(FISCHER344)
                                              ----------------------------
             FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
             IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
 
 
                                                    ----------------
 
                                                    Adrenal Gland
                                                    Bone Marrow
                                                    Brain
                                                    Clitoral Gland
                                                    Epididymis
                                                    Heart
                                                    Islets, Pancreatic
                                                    Kidney
                                                    Liver
                                                    Lung
                                                    Nose
                                                    Ovary
                                                    Pancreas
                                                    Parathyroid Gland
                                                    Pituitary Gland
                                                    Preputial Gland
                                                    Prostate
                                                    Salivary Glands
                                                    Spleen
                                                    Testes
                                                    Thymus
                                                    Thyroid Gland
                                                    Urinary Bladder
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Southern Research Inst                                     FURFURAL                                       DATE: 09/03/94       
EXPERIMENT: 05005 TEST: 07                                                                                     TIME: 05:09:48       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: NO1CP9565101          ROUTE: GAVAGE                                                                      NTP C#: 56177        
PATHOLOGIST: H. GILES                        S. EUSTIS                                                         CAS: 98-01-1         
 
 
 
 
 
                                     SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
                                            IN THE ANALYSIS OF THE STUDY OF FURFURAL
 
              ====================================================================================================
 
                                                           MALE RATS
                                                          -------------
                                 ORGAN                               MORPHOLOGY
                                -------                             ------------
 
                             Testes                        Adenoma
                             Zymbal's Gland                Carcinoma or Adenoma
                             All Organs                    Benign Tumors
 
              ====================================================================================================
 
                                                           FEMALE RATS
                                                          -------------
                                 ORGAN                               MORPHOLOGY
                                -------                             ------------
 
                             Mammary Gland                 Fibroadenoma
                             Pituitary Gland: Pars Distalis or Unspecified Site
                                                           Adenoma
                             All Organs                    Leukemia: Lymphocytic, Monocytic, Mononuclear,
                                                            or Undifferentiated
                                                           Malignant Tumors
                                                           Malignant and Benign Tumors
 
              ====================================================================================================
         DATE: 09/03/94                     EXPERIMENT: 05005 TEST: 07                                                 PAGE   1
                                STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- FURFURAL
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      VEHICLE         30.             60.           |      VEHICLE         30.             60.           |
|                       |      CONTROL         MG/KG           MG/KG         |      CONTROL         MG/KG           MG/KG         |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Pheochromocytoma Benign                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |    11/50 (22%)     13/49 (27%)      5/46 (11%)     |     2/47 (4%)       1/50 (2%)       0/50 (0%)      |
|ADJUSTED (b)           |     34.3%           40.4%           21.2%          |      7.0%            3.1%            0.0%          |
|TERMINAL (d)           |    10/31 (32%)     10/28 (36%)      4/21 (19%)     |     1/27 (4%)       1/32 (3%)       0/18 (0%)      |
|FIRST INCIDENCE (DAYS) |      603             484             582           |      703             729 (T)         ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.251N        P=0.333         P=0.251N       |     P=0.187N        P=0.446N        P=0.323N       |
|INCIDENTAL TUMOR       |     P=0.240N        P=0.273         P=0.200N       |     P=0.143N        P=0.482N        P=0.223N       |
|LOGISTIC REGRESSION    |     P=0.126N        P=0.489         P=0.147N       |     P=0.172N        P=0.462N        P=0.294N       |
|COCHRAN-ARMITAGE       |     P=0.114N                                       |     P=0.132N                                       |
|FISHER EXACT           |                     P=0.385         P=0.117N       |                     P=0.477N        P=0.232N       |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Pheochromocytoma Malignant                                                                                                  |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     2/50 (4%)       3/49 (6%)       1/46 (2%)      |     1/47 (2%)       0/50 (0%)       1/50 (2%)      |
|ADJUSTED (b)           |      6.5%            9.0%            4.8%          |      2.9%            0.0%            3.2%          |
|TERMINAL (d)           |     2/31 (6%)       0/28 (0%)       1/21 (5%)      |     0/27 (0%)       0/32 (0%)       0/18 (0%)      |
|FIRST INCIDENCE (DAYS) |      729 (T)         682             729 (T)       |      645             ---             602           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.508N        P=0.487         P=0.635N       |     P=0.625         P=0.483N        P=0.710        |
|INCIDENTAL TUMOR       |     P=0.283N        P=0.505N        P=0.635N       |     P=0.662         P=0.536N        P=0.765        |
|LOGISTIC REGRESSION    |     P=0.461N        P=0.464N        P=0.635N       |     P=0.648N        P=0.489N        P=0.756N       |
|COCHRAN-ARMITAGE       |     P=0.431N                                       |     P=0.659N                                       |
|FISHER EXACT           |                     P=0.490         P=0.532N       |                     P=0.485N        P=0.737N       |
|=================================================================================================================================|
 
         DATE: 09/03/94                     EXPERIMENT: 05005 TEST: 07                                                 PAGE   2
                                STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- FURFURAL
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      VEHICLE         30.             60.           |      VEHICLE         30.             60.           |
|                       |      CONTROL         MG/KG           MG/KG         |      CONTROL         MG/KG           MG/KG         |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Pheochromocytoma: Benign, Complex, Malignant, NOS                                                                           |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |    11/50 (22%)     16/49 (33%)      6/46 (13%)     |     3/47 (6%)       2/50 (4%)       1/50 (2%)      |
|ADJUSTED (b)           |     34.3%           45.8%           25.8%          |      9.8%            6.3%            3.2%          |
|TERMINAL (d)           |    10/31 (32%)     10/28 (36%)      5/21 (24%)     |     1/27 (4%)       2/32 (6%)       0/18 (0%)      |
|FIRST INCIDENCE (DAYS) |      603             484             582           |      645             729 (T)         602           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.380N        P=0.145         P=0.373N       |     P=0.314N        P=0.435N        P=0.417N       |
|INCIDENTAL TUMOR       |     P=0.271N        P=0.210         P=0.314N       |     P=0.245N        P=0.487N        P=0.293N       |
|LOGISTIC REGRESSION    |     P=0.211N        P=0.241         P=0.236N       |     P=0.261N        P=0.466N        P=0.338N       |
|COCHRAN-ARMITAGE       |     P=0.189N                                       |     P=0.203N                                       |
|FISHER EXACT           |                     P=0.168         P=0.190N       |                     P=0.470N        P=0.285N       |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral/Preputial Gland                                                                                                         |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     1/49 (2%)       4/50 (8%)       2/47 (4%)      |     2/50 (4%)       4/49 (8%)       1/47 (2%)      |
|ADJUSTED (b)           |      2.1%           13.7%            9.5%          |      7.1%           12.5%            4.0%          |
|TERMINAL (d)           |     0/31 (0%)       3/28 (11%)      2/21 (10%)     |     2/28 (7%)       4/32 (13%)      0/17 (0%)      |
|FIRST INCIDENCE (DAYS) |      371             708             729 (T)       |      729 (T)         729 (T)         694           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.286         P=0.162         P=0.408        |     P=0.583N        P=0.399         P=0.635N       |
|INCIDENTAL TUMOR       |     P=0.310         P=0.175         P=0.357        |     P=0.530N        P=0.399         P=0.557N       |
|LOGISTIC REGRESSION    |     P=0.373         P=0.186         P=0.493        |     P=0.549N        P=0.398         P=0.616N       |
|COCHRAN-ARMITAGE       |     P=0.391                                        |     P=0.431N                                       |
|FISHER EXACT           |                     P=0.187         P=0.484        |                     P=0.329         P=0.523N       |
|=================================================================================================================================|
 
         DATE: 09/03/94                     EXPERIMENT: 05005 TEST: 07                                                 PAGE   3
                                STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- FURFURAL
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      VEHICLE         30.             60.           |      VEHICLE         30.             60.           |
|                       |      CONTROL         MG/KG           MG/KG         |      CONTROL         MG/KG           MG/KG         |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral/Preputial Gland                                                                                                         |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     1/49 (2%)       1/50 (2%)       1/47 (2%)      |     2/50 (4%)       1/49 (2%)       2/47 (4%)      |
|ADJUSTED (b)           |      3.2%            3.6%            4.8%          |      7.1%            3.1%           10.6%          |
|TERMINAL (d)           |     1/31 (3%)       1/28 (4%)       1/21 (5%)      |     2/28 (7%)       1/32 (3%)       1/17 (6%)      |
|FIRST INCIDENCE (DAYS) |      729 (T)         729 (T)         729 (T)       |      729 (T)         729 (T)         709           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.538         P=0.739         P=0.673        |     P=0.458         P=0.453N        P=0.521        |
|INCIDENTAL TUMOR       |     P=0.538         P=0.739         P=0.673        |     P=0.529         P=0.453N        P=0.607        |
|LOGISTIC REGRESSION    |     P=0.538         P=0.739         P=0.673        |     P=0.488         P=0.453N        P=0.558        |
|COCHRAN-ARMITAGE       |     P=0.630                                        |     P=0.588                                        |
|FISHER EXACT           |                     P=0.747N        P=0.742        |                     P=0.508N        P=0.668        |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral/Preputial Gland                                                                                                         |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     2/49 (4%)       5/50 (10%)      3/47 (6%)      |     4/50 (8%)       5/49 (10%)      3/47 (6%)      |
|ADJUSTED (b)           |      5.3%           17.1%           14.3%          |     14.3%           15.6%           14.2%          |
|TERMINAL (d)           |     1/31 (3%)       4/28 (14%)      3/21 (14%)     |     4/28 (14%)      5/32 (16%)      1/17 (6%)      |
|FIRST INCIDENCE (DAYS) |      371             708             729 (T)       |      729 (T)         729 (T)         694           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.263         P=0.188         P=0.358        |     P=0.487         P=0.585         P=0.582        |
|INCIDENTAL TUMOR       |     P=0.282         P=0.204         P=0.320        |     P=0.575         P=0.585         P=0.616N       |
|LOGISTIC REGRESSION    |     P=0.367         P=0.233         P=0.468        |     P=0.535         P=0.585         P=0.629        |
|COCHRAN-ARMITAGE       |     P=0.401                                        |     P=0.462N                                       |
|FISHER EXACT           |                     P=0.226         P=0.480        |                     P=0.487         P=0.535N       |
|=================================================================================================================================|
 
         DATE: 09/03/94                     EXPERIMENT: 05005 TEST: 07                                                 PAGE   4
                                STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- FURFURAL
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      VEHICLE         30.             60.           |      VEHICLE         30.             60.           |
|                       |      CONTROL         MG/KG           MG/KG         |      CONTROL         MG/KG           MG/KG         |
|=================================================================================================================================|
|                                                                                                                                 |
|Islets, Pancreatic                                                                                                               |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     4/50 (8%)       5/50 (10%)      2/47 (4%)      |     0/50 (0%)       1/50 (2%)       1/48 (2%)      |
|ADJUSTED (b)           |     12.9%           16.6%            7.0%          |      0.0%            3.1%            2.9%          |
|TERMINAL (d)           |     4/31 (13%)      4/28 (14%)      1/21 (5%)      |     0/28 (0%)       1/32 (3%)       0/18 (0%)      |
|FIRST INCIDENCE (DAYS) |      729 (T)         674             481           |      ---             729 (T)         561           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.443N        P=0.453         P=0.489N       |     P=0.256         P=0.527         P=0.440        |
|INCIDENTAL TUMOR       |     P=0.432N        P=0.541         P=0.543N       |     P=0.219         P=0.527         P=0.362        |
|LOGISTIC REGRESSION    |     P=0.339N        P=0.535         P=0.390N       |     P=0.316         P=0.527         P=0.517        |
|COCHRAN-ARMITAGE       |     P=0.310N                                       |     P=0.324                                        |
|FISHER EXACT           |                     P=0.500         P=0.369N       |                     P=0.500         P=0.490        |
|=================================================================================================================================|
|                                                                                                                                 |
|Islets, Pancreatic                                                                                                               |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     1/50 (2%)       1/50 (2%)       2/47 (4%)      |     0/50 (0%)       0/50 (0%)       0/48 (0%)      |
|ADJUSTED (b)           |      3.1%            2.4%            9.5%          |      0.0%            0.0%            0.0%          |
|TERMINAL (d)           |     0/31 (0%)       0/28 (0%)       2/21 (10%)     |     0/28 (0%)       0/32 (0%)       0/18 (0%)      |
|FIRST INCIDENCE (DAYS) |      697             585             729 (T)       |      ---             ---             ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.311         P=0.743N        P=0.391        |       (e)             (e)             (e)          |
|INCIDENTAL TUMOR       |     P=0.438         P=0.633N        P=0.554        |       (e)             (e)             (e)          |
|LOGISTIC REGRESSION    |     P=0.344         P=0.762         P=0.427        |       (e)             (e)             (e)          |
|COCHRAN-ARMITAGE       |     P=0.359                                        |       (e)                                          |
|FISHER EXACT           |                     P=0.753N        P=0.477        |                       (e)             (e)          |
|=================================================================================================================================|
 
         DATE: 09/03/94                     EXPERIMENT: 05005 TEST: 07                                                 PAGE   5
                                STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- FURFURAL
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      VEHICLE         30.             60.           |      VEHICLE         30.             60.           |
|                       |      CONTROL         MG/KG           MG/KG         |      CONTROL         MG/KG           MG/KG         |
|=================================================================================================================================|
|                                                                                                                                 |
|Islets, Pancreatic                                                                                                               |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     5/50 (10%)      6/50 (12%)      4/47 (9%)      |     0/50 (0%)       1/50 (2%)       1/48 (2%)      |
|ADJUSTED (b)           |     15.6%           18.6%           16.3%          |      0.0%            3.1%            2.9%          |
|TERMINAL (d)           |     4/31 (13%)      4/28 (14%)      3/21 (14%)     |     0/28 (0%)       1/32 (3%)       0/18 (0%)      |
|FIRST INCIDENCE (DAYS) |      697             585             481           |      ---             729 (T)         561           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.511         P=0.468         P=0.583        |     P=0.256         P=0.527         P=0.440        |
|INCIDENTAL TUMOR       |     P=0.543N        P=0.614         P=0.638        |     P=0.219         P=0.527         P=0.362        |
|LOGISTIC REGRESSION    |     P=0.511N        P=0.555         P=0.583N       |     P=0.316         P=0.527         P=0.517        |
|COCHRAN-ARMITAGE       |     P=0.474N                                       |     P=0.324                                        |
|FISHER EXACT           |                     P=0.500         P=0.540N       |                     P=0.500         P=0.490        |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Cholangiocarcinoma                                                                                                          |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     0/50 (0%)       0/50 (0%)       2/50 (4%)      |     0/50 (0%)       0/50 (0%)       0/50 (0%)      |
|ADJUSTED (b)           |      0.0%            0.0%            6.6%          |      0.0%            0.0%            0.0%          |
|TERMINAL (d)           |     0/31 (0%)       0/28 (0%)       1/24 (4%)      |     0/28 (0%)       0/32 (0%)       0/18 (0%)      |
|FIRST INCIDENCE (DAYS) |      ---             ---             564           |      ---             ---             ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.086           (e)           P=0.220        |       (e)             (e)             (e)          |
|INCIDENTAL TUMOR       |     P=0.123           (e)           P=0.271        |       (e)             (e)             (e)          |
|LOGISTIC REGRESSION    |     P=0.094           (e)           P=0.236        |       (e)             (e)             (e)          |
|COCHRAN-ARMITAGE       |     P=0.095                                        |       (e)                                          |
|FISHER EXACT           |                       (e)           P=0.247        |                       (e)             (e)          |
|=================================================================================================================================|
 
         DATE: 09/03/94                     EXPERIMENT: 05005 TEST: 07                                                 PAGE   6
                                STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- FURFURAL
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      VEHICLE         30.             60.           |      VEHICLE         30.             60.           |
|                       |      CONTROL         MG/KG           MG/KG         |      CONTROL         MG/KG           MG/KG         |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma                                                              |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     0/50 (0%)       0/50 (0%)       1/50 (2%)      |     0/50 (0%)       2/50 (4%)       0/50 (0%)      |
|ADJUSTED (b)           |      0.0%            0.0%            4.2%          |      0.0%            5.9%            0.0%          |
|TERMINAL (d)           |     0/31 (0%)       0/28 (0%)       1/24 (4%)      |     0/28 (0%)       1/32 (3%)       0/18 (0%)      |
|FIRST INCIDENCE (DAYS) |      ---             ---             729 (T)       |      ---             668             ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.236           (e)           P=0.449        |     P=0.608         P=0.261           (e)          |
|INCIDENTAL TUMOR       |     P=0.236           (e)           P=0.449        |     P=0.647N        P=0.234           (e)          |
|LOGISTIC REGRESSION    |     P=0.236           (e)           P=0.449        |     P=0.633         P=0.245           (e)          |
|COCHRAN-ARMITAGE       |     P=0.270                                        |     P=0.667N                                       |
|FISHER EXACT           |                       (e)           P=0.500        |                     P=0.247           (e)          |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     0/50 (0%)       1/50 (2%)       0/50 (0%)      |     2/50 (4%)       3/50 (6%)       1/50 (2%)      |
|ADJUSTED (b)           |      0.0%            3.6%            0.0%          |      5.4%            9.4%            5.6%          |
|TERMINAL (d)           |     0/31 (0%)       1/28 (4%)       0/24 (0%)      |     0/28 (0%)       3/32 (9%)       1/18 (6%)      |
|FIRST INCIDENCE (DAYS) |      ---             729 (T)         ---           |      571             729 (T)         729 (T)       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.700         P=0.480           (e)          |     P=0.541N        P=0.542         P=0.615N       |
|INCIDENTAL TUMOR       |     P=0.700         P=0.480           (e)          |     P=0.503N        P=0.472         P=0.555N       |
|LOGISTIC REGRESSION    |     P=0.700         P=0.480           (e)          |     P=0.478N        P=0.514         P=0.545N       |
|COCHRAN-ARMITAGE       |     P=0.730N                                       |     P=0.399N                                       |
|FISHER EXACT           |                     P=0.500           (e)          |                     P=0.500         P=0.500N       |
|=================================================================================================================================|
 
         DATE: 09/03/94                     EXPERIMENT: 05005 TEST: 07                                                 PAGE   7
                                STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- FURFURAL
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      VEHICLE         30.             60.           |      VEHICLE         30.             60.           |
|                       |      CONTROL         MG/KG           MG/KG         |      CONTROL         MG/KG           MG/KG         |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Fibroadenoma                                                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     1/50 (2%)       1/50 (2%)       1/50 (2%)      |    12/50 (24%)     14/50 (28%)     16/50 (32%)     |
|ADJUSTED (b)           |      3.2%            3.6%            3.1%          |     36.7%           39.5%           60.2%          |
|TERMINAL (d)           |     1/31 (3%)       1/28 (4%)       0/24 (0%)      |     8/28 (29%)     11/32 (34%)      8/18 (44%)     |
|FIRST INCIDENCE (DAYS) |      729 (T)         729 (T)         655           |      606             582             602           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.596         P=0.739         P=0.732        |     P=0.032 *       P=0.549         P=0.045 *      |
|INCIDENTAL TUMOR       |     P=0.617N        P=0.739         P=0.660N       |     P=0.073         P=0.418         P=0.092        |
|LOGISTIC REGRESSION    |     P=0.631         P=0.739         P=0.755        |     P=0.052         P=0.460         P=0.062        |
|COCHRAN-ARMITAGE       |     P=0.641                                        |     P=0.218                                        |
|FISHER EXACT           |                     P=0.753N        P=0.753N       |                     P=0.410         P=0.252        |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Fibroma, Fibroadenoma, Carcinoma, or Adenoma                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     1/50 (2%)       2/50 (4%)       1/50 (2%)      |    14/50 (28%)     17/50 (34%)     16/50 (32%)     |
|ADJUSTED (b)           |      3.2%            7.1%            3.1%          |     40.1%           48.2%           60.2%          |
|TERMINAL (d)           |     1/31 (3%)       2/28 (7%)       0/24 (0%)      |     8/28 (29%)     14/32 (44%)      8/18 (44%)     |
|FIRST INCIDENCE (DAYS) |      729 (T)         729 (T)         655           |      571             582             602           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.564         P=0.464         P=0.732        |     P=0.072         P=0.482         P=0.101        |
|INCIDENTAL TUMOR       |     P=0.621N        P=0.464         P=0.660N       |     P=0.150         P=0.325         P=0.200        |
|LOGISTIC REGRESSION    |     P=0.607         P=0.464         P=0.755        |     P=0.118         P=0.378         P=0.149        |
|COCHRAN-ARMITAGE       |     P=0.622N                                       |     P=0.374                                        |
|FISHER EXACT           |                     P=0.500         P=0.753N       |                     P=0.333         P=0.414        |
|=================================================================================================================================|
 
         DATE: 09/03/94                     EXPERIMENT: 05005 TEST: 07                                                 PAGE   8
                                STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- FURFURAL
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      VEHICLE         30.             60.           |      VEHICLE         30.             60.           |
|                       |      CONTROL         MG/KG           MG/KG         |      CONTROL         MG/KG           MG/KG         |
|=================================================================================================================================|
|                                                                                                                                 |
|Mesentery                                                                                                                        |
|     Sarcoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     0/50 (0%)       0/50 (0%)       2/50 (4%)      |     1/50 (2%)       0/50 (0%)       0/50 (0%)      |
|ADJUSTED (b)           |      0.0%            0.0%            5.3%          |      3.2%            0.0%            0.0%          |
|TERMINAL (d)           |     0/31 (0%)       0/28 (0%)       0/24 (0%)      |     0/28 (0%)       0/32 (0%)       0/18 (0%)      |
|FIRST INCIDENCE (DAYS) |      ---             ---             582           |      692             ---             ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.097           (e)           P=0.252        |     P=0.294N        P=0.482N        P=0.543N       |
|INCIDENTAL TUMOR       |     P=0.184           (e)           P=0.371        |     P=0.211N        P=0.536N        P=0.398N       |
|LOGISTIC REGRESSION    |     P=0.099           (e)           P=0.243        |     P=0.292N        P=0.494N        P=0.543N       |
|COCHRAN-ARMITAGE       |     P=0.095                                        |     P=0.272N                                       |
|FISHER EXACT           |                       (e)           P=0.247        |                     P=0.500N        P=0.500N       |
|=================================================================================================================================|
|                                                                                                                                 |
|Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Lip)                                                                           |
|     Papilloma Squamous or Papilloma                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     0/50 (0%)       0/50 (0%)       0/50 (0%)      |     0/50 (0%)       2/50 (4%)       0/50 (0%)      |
|ADJUSTED (b)           |      0.0%            0.0%            0.0%          |      0.0%            5.4%            0.0%          |
|TERMINAL (d)           |     0/31 (0%)       0/28 (0%)       0/24 (0%)      |     0/28 (0%)       1/32 (3%)       0/18 (0%)      |
|FIRST INCIDENCE (DAYS) |      ---             ---             ---           |      ---             582             ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |       (e)             (e)             (e)          |     P=0.602         P=0.254           (e)          |
|INCIDENTAL TUMOR       |       (e)             (e)             (e)          |     P=0.568         P=0.194           (e)          |
|LOGISTIC REGRESSION    |       (e)             (e)             (e)          |     P=0.663         P=0.236           (e)          |
|COCHRAN-ARMITAGE       |       (e)                                          |     P=0.667N                                       |
|FISHER EXACT           |                       (e)             (e)          |                     P=0.247           (e)          |
|=================================================================================================================================|
 
         DATE: 09/03/94                     EXPERIMENT: 05005 TEST: 07                                                 PAGE   9
                                STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- FURFURAL
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      VEHICLE         30.             60.           |      VEHICLE         30.             60.           |
|                       |      CONTROL         MG/KG           MG/KG         |      CONTROL         MG/KG           MG/KG         |
|=================================================================================================================================|
|                                                                                                                                 |
|Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Lip)                                                                           |
|     Squamous Cell Carcinoma, Papilloma Squamous, or Papilloma                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     0/50 (0%)       0/50 (0%)       0/50 (0%)      |     0/50 (0%)       2/50 (4%)       0/50 (0%)      |
|ADJUSTED (b)           |      0.0%            0.0%            0.0%          |      0.0%            5.4%            0.0%          |
|TERMINAL (d)           |     0/31 (0%)       0/28 (0%)       0/24 (0%)      |     0/28 (0%)       1/32 (3%)       0/18 (0%)      |
|FIRST INCIDENCE (DAYS) |      ---             ---             ---           |      ---             582             ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |       (e)             (e)             (e)          |     P=0.602         P=0.254           (e)          |
|INCIDENTAL TUMOR       |       (e)             (e)             (e)          |     P=0.568         P=0.194           (e)          |
|LOGISTIC REGRESSION    |       (e)             (e)             (e)          |     P=0.663         P=0.236           (e)          |
|COCHRAN-ARMITAGE       |       (e)                                          |     P=0.667N                                       |
|FISHER EXACT           |                       (e)             (e)          |                     P=0.247           (e)          |
|=================================================================================================================================|
|                                                                                                                                 |
|Pancreas                                                                                                                         |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     3/50 (6%)       3/50 (6%)       2/47 (4%)      |     0/50 (0%)       0/50 (0%)       1/48 (2%)      |
|ADJUSTED (b)           |      9.7%           10.7%            9.5%          |      0.0%            0.0%            5.6%          |
|TERMINAL (d)           |     3/31 (10%)      3/28 (11%)      2/21 (10%)     |     0/28 (0%)       0/32 (0%)       1/18 (6%)      |
|FIRST INCIDENCE (DAYS) |      729 (T)         729 (T)         729 (T)       |      ---             ---             729 (T)       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.592N        P=0.617         P=0.676N       |     P=0.203           (e)           P=0.412        |
|INCIDENTAL TUMOR       |     P=0.592N        P=0.617         P=0.676N       |     P=0.203           (e)           P=0.412        |
|LOGISTIC REGRESSION    |     P=0.592N        P=0.617         P=0.676N       |     P=0.203           (e)           P=0.412        |
|COCHRAN-ARMITAGE       |     P=0.440N                                       |     P=0.264                                        |
|FISHER EXACT           |                     P=0.661N        P=0.530N       |                       (e)           P=0.490        |
|=================================================================================================================================|
 
         DATE: 09/03/94                     EXPERIMENT: 05005 TEST: 07                                                 PAGE  10
                                STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- FURFURAL
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      VEHICLE         30.             60.           |      VEHICLE         30.             60.           |
|                       |      CONTROL         MG/KG           MG/KG         |      CONTROL         MG/KG           MG/KG         |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |    19/50 (38%)     18/49 (37%)     15/50 (30%)     |    23/49 (47%)     28/50 (56%)     12/50 (24%)     |
|ADJUSTED (b)           |     53.2%           52.1%           51.5%          |     61.1%           71.4%           46.8%          |
|TERMINAL (d)           |    15/31 (48%)     12/28 (43%)     11/24 (46%)     |    13/27 (48%)     21/32 (66%)      6/18 (33%)     |
|FIRST INCIDENCE (DAYS) |      398             585             438           |      571             562             438           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.494N        P=0.579N        P=0.525N       |     P=0.215N        P=0.455         P=0.210N       |
|INCIDENTAL TUMOR       |     P=0.369N        P=0.467N        P=0.551N       |     P=0.074N        P=0.175         P=0.046N*      |
|LOGISTIC REGRESSION    |     P=0.246N        P=0.417N        P=0.281N       |     P=0.060N        P=0.292         P=0.055N       |
|COCHRAN-ARMITAGE       |     P=0.231N                                       |     P=0.013N*                                      |
|FISHER EXACT           |                     P=0.531N        P=0.263N       |                     P=0.242         P=0.014N*      |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Basal Cell Carcinoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     2/50 (4%)       0/50 (0%)       0/50 (0%)      |     0/50 (0%)       0/50 (0%)       0/50 (0%)      |
|ADJUSTED (b)           |      4.6%            0.0%            0.0%          |      0.0%            0.0%            0.0%          |
|TERMINAL (d)           |     0/31 (0%)       0/28 (0%)       0/24 (0%)      |     0/28 (0%)       0/32 (0%)       0/18 (0%)      |
|FIRST INCIDENCE (DAYS) |      444             ---             ---           |      ---             ---             ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.095N        P=0.227N        P=0.237N       |       (e)             (e)             (e)          |
|INCIDENTAL TUMOR       |     P=0.197N        P=0.500N        P=0.371N       |       (e)             (e)             (e)          |
|LOGISTIC REGRESSION    |     P=0.074N        P=0.208N        P=0.183N       |       (e)             (e)             (e)          |
|COCHRAN-ARMITAGE       |     P=0.097N                                       |       (e)                                          |
|FISHER EXACT           |                     P=0.247N        P=0.247N       |                       (e)             (e)          |
|=================================================================================================================================|
 
         DATE: 09/03/94                     EXPERIMENT: 05005 TEST: 07                                                 PAGE  11
                                STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- FURFURAL
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      VEHICLE         30.             60.           |      VEHICLE         30.             60.           |
|                       |      CONTROL         MG/KG           MG/KG         |      CONTROL         MG/KG           MG/KG         |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Keratoacanthoma                                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     2/50 (4%)       1/50 (2%)       4/50 (8%)      |     0/50 (0%)       0/50 (0%)       0/50 (0%)      |
|ADJUSTED (b)           |      6.5%            2.6%           16.7%          |      0.0%            0.0%            0.0%          |
|TERMINAL (d)           |     2/31 (6%)       0/28 (0%)       4/24 (17%)     |     0/28 (0%)       0/32 (0%)       0/18 (0%)      |
|FIRST INCIDENCE (DAYS) |      729 (T)         666             729 (T)       |      ---             ---             ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.162         P=0.501N        P=0.223        |       (e)             (e)             (e)          |
|INCIDENTAL TUMOR       |     P=0.196         P=0.354N        P=0.223        |       (e)             (e)             (e)          |
|LOGISTIC REGRESSION    |     P=0.195         P=0.474N        P=0.223        |       (e)             (e)             (e)          |
|COCHRAN-ARMITAGE       |     P=0.238                                        |       (e)                                          |
|FISHER EXACT           |                     P=0.500N        P=0.339        |                       (e)             (e)          |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Squamous Cell Carcinoma, Papilloma Squamous, or Papilloma                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     2/50 (4%)       1/50 (2%)       0/50 (0%)      |     0/50 (0%)       0/50 (0%)       0/50 (0%)      |
|ADJUSTED (b)           |      6.5%            3.6%            0.0%          |      0.0%            0.0%            0.0%          |
|TERMINAL (d)           |     2/31 (6%)       1/28 (4%)       0/24 (0%)      |     0/28 (0%)       0/32 (0%)       0/18 (0%)      |
|FIRST INCIDENCE (DAYS) |      729 (T)         729 (T)         ---           |      ---             ---             ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.185N        P=0.536N        P=0.296N       |       (e)             (e)             (e)          |
|INCIDENTAL TUMOR       |     P=0.185N        P=0.536N        P=0.296N       |       (e)             (e)             (e)          |
|LOGISTIC REGRESSION    |     P=0.185N        P=0.536N        P=0.296N       |       (e)             (e)             (e)          |
|COCHRAN-ARMITAGE       |     P=0.143N                                       |       (e)                                          |
|FISHER EXACT           |                     P=0.500N        P=0.247N       |                       (e)             (e)          |
|=================================================================================================================================|
 
         DATE: 09/03/94                     EXPERIMENT: 05005 TEST: 07                                                 PAGE  12
                                STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- FURFURAL
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      VEHICLE         30.             60.           |      VEHICLE         30.             60.           |
|                       |      CONTROL         MG/KG           MG/KG         |      CONTROL         MG/KG           MG/KG         |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Trichoepithelioma, Kertatocanthoma, Squamous Cell Carcinoma,                                                                |
|     Basal Cell Carcinoma or Adenoma, Papilloma Squamous, or Papilloma                                                           |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     6/50 (12%)      2/50 (4%)       4/50 (8%)      |     0/50 (0%)       0/50 (0%)       0/50 (0%)      |
|ADJUSTED (b)           |     16.9%            6.0%           16.7%          |      0.0%            0.0%            0.0%          |
|TERMINAL (d)           |     4/31 (13%)      1/28 (4%)       4/24 (17%)     |     0/28 (0%)       0/32 (0%)       0/18 (0%)      |
|FIRST INCIDENCE (DAYS) |      444             666             729 (T)       |      ---             ---             ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.398N        P=0.147N        P=0.501N       |       (e)             (e)             (e)          |
|INCIDENTAL TUMOR       |     P=0.420N        P=0.170N        P=0.580N       |       (e)             (e)             (e)          |
|LOGISTIC REGRESSION    |     P=0.300N        P=0.132N        P=0.382N       |       (e)             (e)             (e)          |
|COCHRAN-ARMITAGE       |     P=0.293N                                       |       (e)                                          |
|FISHER EXACT           |                     P=0.134N        P=0.370N       |                       (e)             (e)          |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin: Subcutaneous Tissue                                                                                                        |
|     Fibroma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     5/50 (10%)      5/50 (10%)      2/50 (4%)      |     0/50 (0%)       0/50 (0%)       0/50 (0%)      |
|ADJUSTED (b)           |     14.9%           15.1%            7.1%          |      0.0%            0.0%            0.0%          |
|TERMINAL (d)           |     3/31 (10%)      3/28 (11%)      1/24 (4%)      |     0/28 (0%)       0/32 (0%)       0/18 (0%)      |
|FIRST INCIDENCE (DAYS) |      583             514             606           |      ---             ---             ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.251N        P=0.612         P=0.292N       |       (e)             (e)             (e)          |
|INCIDENTAL TUMOR       |     P=0.157N        P=0.574N        P=0.140N       |       (e)             (e)             (e)          |
|LOGISTIC REGRESSION    |     P=0.183N        P=0.603N        P=0.227N       |       (e)             (e)             (e)          |
|COCHRAN-ARMITAGE       |     P=0.178N                                       |       (e)                                          |
|FISHER EXACT           |                     P=0.630N        P=0.218N       |                       (e)             (e)          |
|=================================================================================================================================|
 
         DATE: 09/03/94                     EXPERIMENT: 05005 TEST: 07                                                 PAGE  13
                                STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- FURFURAL
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      VEHICLE         30.             60.           |      VEHICLE         30.             60.           |
|                       |      CONTROL         MG/KG           MG/KG         |      CONTROL         MG/KG           MG/KG         |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin: Subcutaneous Tissue                                                                                                        |
|     Fibrosarcoma                                                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     0/50 (0%)       2/50 (4%)       1/50 (2%)      |     0/50 (0%)       1/50 (2%)       0/50 (0%)      |
|ADJUSTED (b)           |      0.0%            6.9%            3.4%          |      0.0%            2.6%            0.0%          |
|TERMINAL (d)           |     0/31 (0%)       1/28 (4%)       0/24 (0%)      |     0/28 (0%)       0/32 (0%)       0/18 (0%)      |
|FIRST INCIDENCE (DAYS) |      ---             709             675           |      ---             618             ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.310         P=0.221         P=0.480        |     P=0.712         P=0.511           (e)          |
|INCIDENTAL TUMOR       |     P=0.499         P=0.386         P=0.773        |     P=0.648         P=0.393           (e)          |
|LOGISTIC REGRESSION    |     P=0.348         P=0.252         P=0.496        |     P=0.725N        P=0.487           (e)          |
|COCHRAN-ARMITAGE       |     P=0.364                                        |     P=0.730N                                       |
|FISHER EXACT           |                     P=0.247         P=0.500        |                     P=0.500           (e)          |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin: Subcutaneous Tissue                                                                                                        |
|     Neurofibrosarcoma, Fibrosarcoma, Sarcoma,                                                                                   |
|     Neurofibroma, or Fibroma                                                                                                    |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     5/50 (10%)      7/50 (14%)      3/50 (6%)      |     0/50 (0%)       1/50 (2%)       0/50 (0%)      |
|ADJUSTED (b)           |     14.9%           21.3%           10.3%          |      0.0%            2.6%            0.0%          |
|TERMINAL (d)           |     3/31 (10%)      4/28 (14%)      1/24 (4%)      |     0/28 (0%)       0/32 (0%)       0/18 (0%)      |
|FIRST INCIDENCE (DAYS) |      583             514             606           |      ---             618             ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.417N        P=0.359         P=0.447N       |     P=0.712         P=0.511           (e)          |
|INCIDENTAL TUMOR       |     P=0.224N        P=0.514         P=0.188N       |     P=0.648         P=0.393           (e)          |
|LOGISTIC REGRESSION    |     P=0.319N        P=0.416         P=0.370N       |     P=0.725N        P=0.487           (e)          |
|COCHRAN-ARMITAGE       |     P=0.307N                                       |     P=0.730N                                       |
|FISHER EXACT           |                     P=0.380         P=0.357N       |                     P=0.500           (e)          |
|=================================================================================================================================|
 
         DATE: 09/03/94                     EXPERIMENT: 05005 TEST: 07                                                 PAGE  14
                                STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- FURFURAL
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      VEHICLE         30.             60.           |      VEHICLE         30.             60.           |
|                       |      CONTROL         MG/KG           MG/KG         |      CONTROL         MG/KG           MG/KG         |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach                                                                                                             |
|     Squamous Cell Carcinoma or Papilloma Squamous                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     0/50 (0%)       1/50 (2%)       2/50 (4%)      |     0/50 (0%)       1/50 (2%)       1/50 (2%)      |
|ADJUSTED (b)           |      0.0%            2.2%            8.3%          |      0.0%            3.1%            5.6%          |
|TERMINAL (d)           |     0/31 (0%)       0/28 (0%)       2/24 (8%)      |     0/28 (0%)       1/32 (3%)       1/18 (6%)      |
|FIRST INCIDENCE (DAYS) |      ---             514             729 (T)       |      ---             729 (T)         729 (T)       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.117         P=0.523         P=0.183        |     P=0.240         P=0.527         P=0.412        |
|INCIDENTAL TUMOR       |     P=0.093         P=0.282         P=0.183        |     P=0.240         P=0.527         P=0.412        |
|LOGISTIC REGRESSION    |     P=0.140         P=0.506         P=0.183        |     P=0.240         P=0.527         P=0.412        |
|COCHRAN-ARMITAGE       |     P=0.143                                        |     P=0.333                                        |
|FISHER EXACT           |                     P=0.500         P=0.247        |                     P=0.500         P=0.500        |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach                                                                                                             |
|     Squamous Cell Papilloma                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     0/50 (0%)       0/50 (0%)       2/50 (4%)      |     0/50 (0%)       1/50 (2%)       1/50 (2%)      |
|ADJUSTED (b)           |      0.0%            0.0%            8.3%          |      0.0%            3.1%            5.6%          |
|TERMINAL (d)           |     0/31 (0%)       0/28 (0%)       2/24 (8%)      |     0/28 (0%)       1/32 (3%)       1/18 (6%)      |
|FIRST INCIDENCE (DAYS) |      ---             ---             729 (T)       |      ---             729 (T)         729 (T)       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.071           (e)           P=0.183        |     P=0.240         P=0.527         P=0.412        |
|INCIDENTAL TUMOR       |     P=0.071           (e)           P=0.183        |     P=0.240         P=0.527         P=0.412        |
|LOGISTIC REGRESSION    |     P=0.071           (e)           P=0.183        |     P=0.240         P=0.527         P=0.412        |
|COCHRAN-ARMITAGE       |     P=0.095                                        |     P=0.333                                        |
|FISHER EXACT           |                       (e)           P=0.247        |                     P=0.500         P=0.500        |
|=================================================================================================================================|
 
         DATE: 09/03/94                     EXPERIMENT: 05005 TEST: 07                                                 PAGE  15
                                STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- FURFURAL
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      VEHICLE         30.             60.           |      VEHICLE         30.             60.           |
|                       |      CONTROL         MG/KG           MG/KG         |      CONTROL         MG/KG           MG/KG         |
|=================================================================================================================================|
|                                                                                                                                 |
|Testes                                                                                                                           |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |    38/50 (76%)     44/50 (88%)     39/50 (78%)     |                                                    |
|ADJUSTED (b)           |     90.4%          100.0%          100.0%          |                                                    |
|TERMINAL (d)           |    27/31 (87%)     28/28 (100%)    24/24 (100%)    |                                                    |
|FIRST INCIDENCE (DAYS) |      444             484             481           |                                                    |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.081         P=0.122         P=0.112        |                                                    |
|INCIDENTAL TUMOR       |     P=0.343         P=0.036 *       P=0.471        |                                                    |
|LOGISTIC REGRESSION    |     P=0.453         P=0.148         P=0.514        |                                                    |
|COCHRAN-ARMITAGE       |     P=0.453                                        |                                                    |
|FISHER EXACT           |                     P=0.096         P=0.500        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: C-Cell                                                                                                            |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     4/50 (8%)       2/50 (4%)       2/50 (4%)      |     4/50 (8%)       2/50 (4%)       1/50 (2%)      |
|ADJUSTED (b)           |     12.2%            7.1%            8.3%          |     14.3%            5.4%            5.6%          |
|TERMINAL (d)           |     3/31 (10%)      2/28 (7%)       2/24 (8%)      |     4/28 (14%)      1/32 (3%)       1/18 (6%)      |
|FIRST INCIDENCE (DAYS) |      583             729 (T)         729 (T)       |      729 (T)         599             729 (T)       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.341N        P=0.366N        P=0.436N       |     P=0.201N        P=0.284N        P=0.331N       |
|INCIDENTAL TUMOR       |     P=0.307N        P=0.395N        P=0.391N       |     P=0.220N        P=0.325N        P=0.331N       |
|LOGISTIC REGRESSION    |     P=0.271N        P=0.303N        P=0.359N       |     P=0.170N        P=0.315N        P=0.331N       |
|COCHRAN-ARMITAGE       |     P=0.253N                                       |     P=0.119N                                       |
|FISHER EXACT           |                     P=0.339N        P=0.339N       |                     P=0.339N        P=0.181N       |
|=================================================================================================================================|
 
         DATE: 09/03/94                     EXPERIMENT: 05005 TEST: 07                                                 PAGE  16
                                STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- FURFURAL
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      VEHICLE         30.             60.           |      VEHICLE         30.             60.           |
|                       |      CONTROL         MG/KG           MG/KG         |      CONTROL         MG/KG           MG/KG         |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: C-Cell                                                                                                            |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     5/50 (10%)      2/50 (4%)       2/50 (4%)      |     4/50 (8%)       3/50 (6%)       1/50 (2%)      |
|ADJUSTED (b)           |     15.3%            7.1%            8.3%          |     14.3%            8.5%            5.6%          |
|TERMINAL (d)           |     4/31 (13%)      2/28 (7%)       2/24 (8%)      |     4/28 (14%)      2/32 (6%)       1/18 (6%)      |
|FIRST INCIDENCE (DAYS) |      583             729 (T)         729 (T)       |      729 (T)         599             729 (T)       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.217N        P=0.244N        P=0.310N       |     P=0.233N        P=0.434N        P=0.331N       |
|INCIDENTAL TUMOR       |     P=0.193N        P=0.267N        P=0.272N       |     P=0.251N        P=0.478N        P=0.331N       |
|LOGISTIC REGRESSION    |     P=0.160N        P=0.185N        P=0.238N       |     P=0.196N        P=0.472N        P=0.331N       |
|COCHRAN-ARMITAGE       |     P=0.147N                                       |     P=0.133N                                       |
|FISHER EXACT           |                     P=0.218N        P=0.218N       |                     P=0.500N        P=0.181N       |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Polyp Stromal                                                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |                                                    |    12/50 (24%)      9/50 (18%)     14/50 (28%)     |
|ADJUSTED (b)           |                                                    |     36.4%           23.8%           51.0%          |
|TERMINAL (d)           |                                                    |     8/28 (29%)      5/32 (16%)      6/18 (33%)     |
|FIRST INCIDENCE (DAYS) |                                                    |      585             599             327           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                                                    |     P=0.114         P=0.230N        P=0.117        |
|INCIDENTAL TUMOR       |                                                    |     P=0.199         P=0.376N        P=0.239        |
|LOGISTIC REGRESSION    |                                                    |     P=0.214         P=0.283N        P=0.219        |
|COCHRAN-ARMITAGE       |                                                    |     P=0.360                                        |
|FISHER EXACT           |                                                    |                     P=0.312N        P=0.410        |
|=================================================================================================================================|
 
         DATE: 09/03/94                     EXPERIMENT: 05005 TEST: 07                                                 PAGE  17
                                STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- FURFURAL
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      VEHICLE         30.             60.           |      VEHICLE         30.             60.           |
|                       |      CONTROL         MG/KG           MG/KG         |      CONTROL         MG/KG           MG/KG         |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Sarcoma Stromal                                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |                                                    |     2/50 (4%)       2/50 (4%)       0/50 (0%)      |
|ADJUSTED (b)           |                                                    |      5.8%            5.1%            0.0%          |
|TERMINAL (d)           |                                                    |     0/28 (0%)       1/32 (3%)       0/18 (0%)      |
|FIRST INCIDENCE (DAYS) |                                                    |      605             388             ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                                                    |     P=0.231N        P=0.662N        P=0.302N       |
|INCIDENTAL TUMOR       |                                                    |     P=0.094N        P=0.567N        P=0.235N       |
|LOGISTIC REGRESSION    |                                                    |     P=0.157N        P=0.666         P=0.253N       |
|COCHRAN-ARMITAGE       |                                                    |     P=0.176N                                       |
|FISHER EXACT           |                                                    |                     P=0.691N        P=0.247N       |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Sarcoma Stromal or Polyp Stromal                                                                                            |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |                                                    |    13/50 (26%)     11/50 (22%)     14/50 (28%)     |
|ADJUSTED (b)           |                                                    |     38.0%           28.1%           51.0%          |
|TERMINAL (d)           |                                                    |     8/28 (29%)      6/32 (19%)      6/18 (33%)     |
|FIRST INCIDENCE (DAYS) |                                                    |      585             388             327           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                                                    |     P=0.160         P=0.310N        P=0.162        |
|INCIDENTAL TUMOR       |                                                    |     P=0.303         P=0.397N        P=0.299        |
|LOGISTIC REGRESSION    |                                                    |     P=0.318         P=0.387N        P=0.300        |
|COCHRAN-ARMITAGE       |                                                    |     P=0.453                                        |
|FISHER EXACT           |                                                    |                     P=0.408N        P=0.500        |
|=================================================================================================================================|
 
         DATE: 09/03/94                     EXPERIMENT: 05005 TEST: 07                                                 PAGE  18
                                STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- FURFURAL
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      VEHICLE         30.             60.           |      VEHICLE         30.             60.           |
|                       |      CONTROL         MG/KG           MG/KG         |      CONTROL         MG/KG           MG/KG         |
|=================================================================================================================================|
|                                                                                                                                 |
|Zymbal's Gland                                                                                                                   |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     2/50 (4%)       0/50 (0%)       0/50 (0%)      |     0/50 (0%)       0/50 (0%)       0/50 (0%)      |
|ADJUSTED (b)           |      5.6%            0.0%            0.0%          |      0.0%            0.0%            0.0%          |
|TERMINAL (d)           |     1/31 (3%)       0/28 (0%)       0/24 (0%)      |     0/28 (0%)       0/32 (0%)       0/18 (0%)      |
|FIRST INCIDENCE (DAYS) |      484             ---             ---           |      ---             ---             ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.107N        P=0.238N        P=0.265N       |       (e)             (e)             (e)          |
|INCIDENTAL TUMOR       |     P=0.163N        P=0.367N        P=0.335N       |       (e)             (e)             (e)          |
|LOGISTIC REGRESSION    |     P=0.095N        P=0.241N        P=0.234N       |       (e)             (e)             (e)          |
|COCHRAN-ARMITAGE       |     P=0.097N                                       |       (e)                                          |
|FISHER EXACT           |                     P=0.247N        P=0.247N       |                       (e)             (e)          |
|=================================================================================================================================|
|                                                                                                                                 |
|Zymbal's Gland                                                                                                                   |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     3/50 (6%)       0/50 (0%)       0/50 (0%)      |     0/50 (0%)       0/50 (0%)       0/50 (0%)      |
|ADJUSTED (b)           |      8.4%            0.0%            0.0%          |      0.0%            0.0%            0.0%          |
|TERMINAL (d)           |     1/31 (3%)       0/28 (0%)       0/24 (0%)      |     0/28 (0%)       0/32 (0%)       0/18 (0%)      |
|FIRST INCIDENCE (DAYS) |      484             ---             ---           |      ---             ---             ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.042N*       P=0.113N        P=0.140N       |       (e)             (e)             (e)          |
|INCIDENTAL TUMOR       |     P=0.034N*       P=0.078N        P=0.085N       |       (e)             (e)             (e)          |
|LOGISTIC REGRESSION    |     P=0.037N*       P=0.123N        P=0.119N       |       (e)             (e)             (e)          |
|COCHRAN-ARMITAGE       |     P=0.038N*                                      |       (e)                                          |
|FISHER EXACT           |                     P=0.121N        P=0.121N       |                       (e)             (e)          |
|=================================================================================================================================|
 
         DATE: 09/03/94                     EXPERIMENT: 05005 TEST: 07                                                 PAGE  19
                                STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- FURFURAL
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      VEHICLE         30.             60.           |      VEHICLE         30.             60.           |
|                       |      CONTROL         MG/KG           MG/KG         |      CONTROL         MG/KG           MG/KG         |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Leukemia: Lymphocytic, Monocytic, Mononuclear,                                                                              |
|     or Undifferentiated                                                                                                         |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |    13/50 (26%)     15/50 (30%)     15/50 (30%)     |    18/50 (36%)     15/50 (30%)      8/50 (16%)     |
|ADJUSTED (b)           |     37.6%           41.5%           48.3%          |     45.0%           42.0%           31.2%          |
|TERMINAL (d)           |    10/31 (32%)      8/28 (29%)      9/24 (38%)     |     8/28 (29%)     12/32 (38%)      3/18 (17%)     |
|FIRST INCIDENCE (DAYS) |      448             666             568           |      210             459             602           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.192         P=0.389         P=0.225        |     P=0.127N        P=0.245N        P=0.160N       |
|INCIDENTAL TUMOR       |     P=0.502         P=0.401N        P=0.485        |     P=0.067N        P=0.363N        P=0.094N       |
|LOGISTIC REGRESSION    |     P=0.331         P=0.497         P=0.375        |     P=0.032N*       P=0.319N        P=0.035N*      |
|COCHRAN-ARMITAGE       |     P=0.371                                        |     P=0.016N*                                      |
|FISHER EXACT           |                     P=0.412         P=0.412        |                     P=0.335N        P=0.020N*      |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Mesothelioma Benign, Malignant, NOS                                                                                         |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     3/50 (6%)       3/50 (6%)       2/50 (4%)      |     0/50 (0%)       0/50 (0%)       0/50 (0%)      |
|ADJUSTED (b)           |      7.8%            9.6%            7.1%          |      0.0%            0.0%            0.0%          |
|TERMINAL (d)           |     0/31 (0%)       2/28 (7%)       0/24 (0%)      |     0/28 (0%)       0/32 (0%)       0/18 (0%)      |
|FIRST INCIDENCE (DAYS) |      517             668             657           |      ---             ---             ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.458N        P=0.635N        P=0.517N       |       (e)             (e)             (e)          |
|INCIDENTAL TUMOR       |     P=0.330N        P=0.586         P=0.318N       |       (e)             (e)             (e)          |
|LOGISTIC REGRESSION    |     P=0.413N        P=0.658         P=0.491N       |       (e)             (e)             (e)          |
|COCHRAN-ARMITAGE       |     P=0.412N                                       |       (e)                                          |
|FISHER EXACT           |                     P=0.661N        P=0.500N       |                       (e)             (e)          |
|=================================================================================================================================|
 
         DATE: 09/03/94                     EXPERIMENT: 05005 TEST: 07                                                 PAGE  20
                                STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- FURFURAL
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      VEHICLE         30.             60.           |      VEHICLE         30.             60.           |
|                       |      CONTROL         MG/KG           MG/KG         |      CONTROL         MG/KG           MG/KG         |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Benign Tumors                                                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |    47/50 (94%)     46/50 (92%)     43/50 (86%)     |    36/50 (72%)     38/50 (76%)     32/50 (64%)     |
|ADJUSTED (b)           |    100.0%          100.0%          100.0%          |     85.6%           90.3%           91.3%          |
|TERMINAL (d)           |    31/31 (100%)    28/28 (100%)    24/24 (100%)    |    22/28 (79%)     28/32 (88%)     15/18 (83%)     |
|FIRST INCIDENCE (DAYS) |      371             484             438           |      571             465             327           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.303         P=0.536         P=0.361        |     P=0.105         P=0.431N        P=0.131        |
|INCIDENTAL TUMOR       |     P=0.059N          (e)           P=0.144N       |     P=0.256         P=0.377         P=0.326        |
|LOGISTIC REGRESSION    |     P=0.035N*         (e)           P=0.081N       |     P=0.301         P=0.493         P=0.364        |
|COCHRAN-ARMITAGE       |     P=0.114N                                       |     P=0.220N                                       |
|FISHER EXACT           |                     P=0.500N        P=0.159N       |                     P=0.410         P=0.260N       |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant Tumors                                                                                                            |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |    23/50 (46%)     24/50 (48%)     26/50 (52%)     |    24/50 (48%)     24/50 (48%)      9/50 (18%)     |
|ADJUSTED (b)           |     57.0%           58.1%           69.8%          |     57.2%           64.1%           35.8%          |
|TERMINAL (d)           |    14/31 (45%)     11/28 (39%)     13/24 (54%)     |    11/28 (39%)     19/32 (59%)      4/18 (22%)     |
|FIRST INCIDENCE (DAYS) |      444             514             564           |      210             388             602           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.145         P=0.484         P=0.170        |     P=0.048N*       P=0.407N        P=0.053N       |
|INCIDENTAL TUMOR       |     P=0.542N        P=0.361N        P=0.571        |     P=0.010N*       P=0.534N        P=0.013N*      |
|LOGISTIC REGRESSION    |     P=0.479         P=0.513N        P=0.476        |     P=0.004N**      P=0.549N        P=0.004N**     |
|COCHRAN-ARMITAGE       |     P=0.309                                        |     P=0.001N**                                     |
|FISHER EXACT           |                     P=0.500         P=0.345        |                     P=0.579N        P=0.001N**     |
|=================================================================================================================================|
 
         DATE: 09/03/94                     EXPERIMENT: 05005 TEST: 07                                                 PAGE  21
                                STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- FURFURAL
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      VEHICLE         30.             60.           |      VEHICLE         30.             60.           |
|                       |      CONTROL         MG/KG           MG/KG         |      CONTROL         MG/KG           MG/KG         |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant and Benign Tumors                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |    47/50 (94%)     46/50 (92%)     44/50 (88%)     |    43/50 (86%)     44/50 (88%)     33/50 (66%)     |
|ADJUSTED (b)           |    100.0%          100.0%          100.0%          |     93.5%           95.6%           91.6%          |
|TERMINAL (d)           |    31/31 (100%)    28/28 (100%)    24/24 (100%)    |    25/28 (89%)     30/32 (94%)     15/18 (83%)     |
|FIRST INCIDENCE (DAYS) |      371             484             438           |      210             388             327           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.248         P=0.536         P=0.303        |     P=0.349         P=0.343N        P=0.372        |
|INCIDENTAL TUMOR       |     P=0.108N          (e)           P=0.230N       |     P=0.165N        P=0.599         P=0.290N       |
|LOGISTIC REGRESSION    |     P=0.076N          (e)           P=0.160N       |     P=0.104N        P=0.594N        P=0.159N       |
|COCHRAN-ARMITAGE       |     P=0.187N                                       |     P=0.009N**                                     |
|FISHER EXACT           |                     P=0.500N        P=0.243N       |                     P=0.500         P=0.017N*      |
|=================================================================================================================================|
 
 (a)  Number of tumor-bearing animals / number of animals examined at site.
 (b)  Kaplan-Meier estimated lifetime tumor incidence after adjustment for 
      intercurrent mortality.
 (d)  Observed incidence at terminal kill.
 (f)  Beneath the control incidence are the P-values associated with the trend 
      test.  Beneath the dosed group incidence are the P-values corresponding to 
      pairwise comparisons between the controls and that dosed group.  The life
      table analysis regards tumors in animals dying  prior to terminal kill as
      being (directly or indirectly) the cause of death.  The incidental tumor 
      test regards these lesions as non-fatal.  Logistic regression is an alternative
      method for analyzing the incidence of non-fatal tumors.  The Cochran-Armitage
      and Fisher's exact tests compare directly the overall incidence rates.  
      For all tests, a negative trend is indicated by "N".
 (e)  Value of Statistic cannot be computed. 
 (I)  Interim sacrifice
 (T)  Terminal sacrifice
  #   Tumor rates based on number of animals necropsied.
 
  *   To the right of any statistical result, indicates significance at (P<=0.05).
  **  To the right of any statistical result, indicates significance at (P<=0.01).

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