Share This:
https://ntp.niehs.nih.gov/go/3114

TR 382 Rat Pathology Tables

NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11 
LAB: Southern Research Inst                                    DATE: 09/03/94   
EXP: 05005                        FURFURAL                     TIME: 05:09:59   
TEST: 07              CAGES FROM 0000 TO LAST CAGE             PAGE:   1        
TEST TYPE: CHRONIC          ROUTE: GAVAGE                      NTP C#: 56177    
CONT: NO1CP9565101                                             CAS: 98-01-1     
PATHOLOGIST: H. GILES                        S. EUSTIS                          
--------------------------------------------------------------------------------
                                                                                
                                                                                
                                                                                


REASONS FOR REMOVAL:                                                            
                                                                                
ALL                                                                             
                                                                                
                                                                                
REMOVAL DATE RANGE:                                                             


ALL                                                                             
                                                                                
TREATMENT GROUPS:                                                               
                                                                                
INCLUDE ALL                                                                     

NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11
LAB: Southern Research Inst                                    DATE: 09/03/94  
EXP: 05005                        FURFURAL                     TIME: 05:09:59  
TEST: 07              CAGES FROM 0000 TO LAST CAGE                             
TEST TYPE: CHRONIC          ROUTE: GAVAGE                      NTP C#: 56177   
CONT: NO1CP9565101                                             CAS: 98-01-1    
PATHOLOGIST: H. GILES                        S. EUSTIS                         

                                     FURFURAL


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE RATS
                       FIRST TERMINAL SACRIFICE AT 729 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                          DOSE = VEHICLE CONTROL                                |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 13     CENSORED DEATHS 6    TERMINAL 31        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      340   444   448   470   484   517   517   554   583   595                 |
 |      603   654   697                                                           |
 |  CENSORED DEATHS                                                               |
 |      267   292   371   398   451   564                                         |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = 30.     MG/KG                                  |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 15     CENSORED DEATHS 7    TERMINAL 28        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      484   514   585   622   666   668   674   676   676   682                 |
 |      693   702   707   708   709                                               |
 |  CENSORED DEATHS                                                               |
 |      101   113   276   329   536   551   561                                   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = 60.     MG/KG                                  |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 18     CENSORED DEATHS 8    TERMINAL 24        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      438   479   481   508   568   582   589   597   604   606                 |
 |      655   655   657   675   676   702   708   708                             |
 |  CENSORED DEATHS                                                               |
 |      84    99    287   309   371   547   564   599                             |
 |                                                                                |
 ==================================================================================

                                     FURFURAL


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE RATS
                       FIRST TERMINAL SACRIFICE AT 729 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   729 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |VEHICLE    |   100.0 100.0 100.0  97.9  97.9  89.1  84.7  75.6  73.3  71.0      |
 |CONTROL    |                                                                    |
 |           |                                                                    |
 |30.        |   100.0 100.0 100.0 100.0 100.0  97.8  95.7  93.3  91.0  65.3      |
 |MG/KG      |                                                                    |
 |           |                                                                    |
 |60.        |   100.0 100.0 100.0 100.0 100.0  93.3  91.1  79.4  69.7  57.7      |
 |MG/KG      |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                    DOSE                        |
 |                                                                                |
 |                                VEHICLE          30.              60.           |
 |                                CONTROL          MG/KG            MG/KG         |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       71.0%            65.3%            57.7%         |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=0.343          P=1.000          P=0.451       |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       531.2            651.1            604.9         |
 |NATURAL DEATHS (C)      |       (26.8)           (18.2)           (19.7)        |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       637.0            652.9            624.9         |
 |(STANDARD ERROR)        |       (19.6)           (21.3)           (22.5)        |
 |                        |                                                       |
 ==================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                                     FURFURAL


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE RATS
                       FIRST TERMINAL SACRIFICE AT 729 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                          DOSE = VEHICLE CONTROL                                |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 18     CENSORED DEATHS 4    TERMINAL 28        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      210   217   567   571   589   592   605   605   606   626                 |
 |      631   637   645   686   690   692   697   703                             |
 |  CENSORED DEATHS                                                               |
 |      177   178   567   585                                                     |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = 30.     MG/KG                                  |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 16     CENSORED DEATHS 2    TERMINAL 32        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      346   388   459   531   562   582   599   610   611   618                 |
 |      633   654   661   668   700   709                                         |
 |  CENSORED DEATHS                                                               |
 |      354   465                                                                 |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = 60.     MG/KG                                  |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 13     CENSORED DEATHS 19   TERMINAL 18        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      438   602   627   632   653   654   662   694   694   698                 |
 |      708   709   717                                                           |
 |  CENSORED DEATHS                                                               |
 |      161   267   267   297   297   297   297   327   327   374                 |
 |      378   440   466   509   557   561   564   564   698                       |
 |                                                                                |
 ==================================================================================

                                     FURFURAL


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE RATS
                       FIRST TERMINAL SACRIFICE AT 729 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   729 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |VEHICLE    |   100.0 100.0  95.8  95.8  95.8  95.8  95.8  82.9  72.0  61.1      |
 |CONTROL    |                                                                    |
 |           |                                                                    |
 |30.        |   100.0 100.0 100.0  98.0  96.0  93.9  91.8  85.6  73.0  66.8      |
 |MG/KG      |                                                                    |
 |           |                                                                    |
 |60.        |   100.0 100.0 100.0 100.0 100.0  97.4  97.4  94.3  78.6  59.3      |
 |MG/KG      |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                    DOSE                        |
 |                                                                                |
 |                                VEHICLE          30.              60.           |
 |                                CONTROL          MG/KG            MG/KG         |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       61.1%            66.8%            59.3%         |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=0.849N         P=0.741N         P=0.943N      |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       587.2            583.2            652.9         |
 |NATURAL DEATHS (C)      |       (33.7)           (26.3)           (20.5)        |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       649.8            669.6            585.2         |
 |(STANDARD ERROR)        |       (20.7)           (14.8)           (24.7)        |
 |                        |                                                       |
 ==================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                                                              FURFURAL
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        VEHICLE CONTROL  = 1
                                                        30.     MG/KG    = 2
                                                        60.     MG/KG    = 3

------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  100 + 1                                                     1              3       2
      |
      |                                                       1              31     32   2
      |                                                                                  2          2
   95 +
      |                                                                       1    13   3           2     2
      |
      |                                                                            1 1  3         3       2       2
   90 +
      |                                                                              1   1        3 3
P     |
E     |                                                                                             3 3           22
R  85 +                                                                                  1      1
C     |                                                                                               33
E     |                                                                                         1   1
N     |                                                                                                33
T  80 +                                                                                             1 1
      |                                                                                                            22
S     |                                                                                               1 1      3    22
U     |
R  75 +                                                                                                 1      1     2 2
V     |                                                                                                        1      1
I     |
V     |                                                                                                               1     1
A  70 +                                                                                                        3   3   22
L     |
      |
      |
   65 +                                                                                                            3   32   2
      |
      |                                                                                                                33
      |
   60 +
      |
      |                                                                                                                 3   3
      |
   55 +
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 3 obs hidden.

                                                              FURFURAL
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        VEHICLE CONTROL  = 1
                                                        30.     MG/KG    = 2
                                                        60.     MG/KG    = 3

----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  100 + 1                                1                     2             3
      |
      |                                  11                    2      2      3                         3
      |                                   1                           2          2               1
   95 +
      |                                                                          2          2    11    3   3
      |
      |                                                                                     2    21   1    33
   90 +                                                                                          2  2
      |
P     |                                                                                             2 121   3  3
E     |
R  85 +                                                                                                2 2
C     |
E     |
N     |                                                                                                 1221   3 3
T  80 +
      |                                                                                                   211    3    3
S     |                                                                                                     2  2
U     |
R  75 +                                                                                                        2 2
V     |                                                                                                     1 1
I     |                                                                                                       1  22 1
V     |                                                                                                           2   2
A  70 +                                                                                                             11
L     |                                                                                                               2 2
      |
      |                                                                                                                 2   2
   65 +                                                                                                              11
      |                                                                                                               11
      |                                                                                                                 33
      |                                                                                                                1    1
   60 +
      |                                                                                                                  3  3
      |
      |
   55 +
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 5 obs hidden.

--multipart-boundary
Content-type: text/plain
Range: bytes 25012-25012/25012


--multipart-boundary--