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TR 383 Rat Pathology Tables

NTP Experiment-Test: 05061-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/25/97
Route: DOSED FEED                                                                                                 Time: 17:56:58




       Facility:  TSI Mason Research

       Chemical CAS #:  81-49-2

       Lock Date:  03/25/92

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All




































Note:  Animals arranged according to CID number

                                                              Page   1

NTP Experiment-Test: 05061-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 17:56:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 4| 2| 7| 7| 7| 4| 2| 7| 7| 7| 6| 2| 7| 7| 4| 2| 2| 7| 7| 7| 6| 4|             
                             DAY ON TEST   | 3| 3| 0| 6| 8| 3| 3| 3| 6| 8| 3| 3| 3| 0| 6| 3| 3| 6| 8| 8| 3| 3| 3| 7| 6|             
                                           | 4| 4| 1| 2| 1| 4| 4| 4| 2| 1| 5| 5| 5| 6| 8| 5| 5| 2| 1| 1| 6| 6| 6| 5| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    UNTREATE                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    D 71UF                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                              X                       X   |             
                                            __________________________________________________________________________|             
   Mesentery                               |                +                                +              +         |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                      X   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                      +   |             
      Leukemia Mononuclear                 |                                                                      X   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                      X   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Adenoma                              |                               X                                          |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                      X   |             
      Pheochromocytoma Benign              |                                  X              X                        |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +        +  +  +        +  +  +  +  +  +  +           +  +  +  +   |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                   X      |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               | X  X     X        X           X  X              X           X  X  X  X  X|             
      Pars Distalis, Adenoma, Multiple     |                                              X                           |             
      Pars Distalis, Leukemia Mononuclear  |                                                                      X   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Adenoma                      | X  X              X           X                                          |             
      C-Cell, Carcinoma                    |    X                                                                     |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05061-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 17:56:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 4| 2| 7| 7| 7| 4| 2| 7| 7| 7| 6| 2| 7| 7| 4| 2| 2| 7| 7| 7| 6| 4|             
                             DAY ON TEST   | 3| 3| 0| 6| 8| 3| 3| 3| 6| 8| 3| 3| 3| 0| 6| 3| 3| 6| 8| 8| 3| 3| 3| 7| 6|             
                                           | 4| 4| 1| 2| 1| 4| 4| 4| 2| 1| 5| 5| 5| 6| 8| 5| 5| 2| 1| 1| 6| 6| 6| 5| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    UNTREATE                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    D 71UF                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM - cont                |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                        +  +                              |             
      Sarcoma                              |                                        X  X                              |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +|             
      Adenoma                              |    X                                         X                           |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granulosa Cell Tumor Benign          |                                                                          |             
      Leukemia Mononuclear                 |                                                                      X   |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma                       |       X                                                                  |             
      Hemangioma                           |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
      Polyp Stromal                        |                               X                 X           X           X|             
      Polyp Stromal, Multiple              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                      X   |             
                                            __________________________________________________________________________|             
   Lymph Node                              |             M              M              +           M  M               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  I  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                      X   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                      X   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                              X                       X   |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  I  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Adenocarcinoma                       |    X                                                                     |             
      Fibroadenoma                         |          X           X        X  X     X        X              X  X      |             
      Fibroadenoma, Multiple               |                   X                                                      |             
      Fibroma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Squamous Cell Papilloma              |                                                                          |             
      Subcutaneous Tissue, Fibroma         |                                                                          |             
      Subcutaneous Tissue, Sarcoma         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05061-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 17:56:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 4| 2| 7| 7| 7| 4| 2| 7| 7| 7| 6| 2| 7| 7| 4| 2| 2| 7| 7| 7| 6| 4|             
                             DAY ON TEST   | 3| 3| 0| 6| 8| 3| 3| 3| 6| 8| 3| 3| 3| 0| 6| 3| 3| 6| 8| 8| 3| 3| 3| 7| 6|             
                                           | 4| 4| 1| 2| 1| 4| 4| 4| 2| 1| 5| 5| 5| 6| 8| 5| 5| 2| 1| 1| 6| 6| 6| 5| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    UNTREATE                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    D 71UF                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                                                          |             
      Leukemia Mononuclear                 |                                                                      X   |             
      Sarcoma, Metastatic, Thymus          |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |             M              M                          M  M               |             
                                            __________________________________________________________________________|             
   Eye                                     |    +              +              +                             +     +   |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
      Squamous Cell Carcinoma              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                      X   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                      X   |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                              X                       X   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05061-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 17:56:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 2| 7| 7| 6| 4| 2| 7| 7| 6| 6| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2|             
                             DAY ON TEST   | 3| 3| 3| 0| 7| 3| 3| 5| 6| 7| 3| 3| 5| 4| 8| 3| 3| 3| 3| 1| 3| 3| 3| 3| 8|             
                                           | 6| 6| 6| 4| 9| 6| 6| 6| 2| 9| 4| 1| 8| 2| 1| 4| 4| 5| 5| 9| 4| 4| 4| 5| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    UNTREATE                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    D 71UF                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                X                 X              X  X                     |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                  X                                       |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                  X                                       |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Adenoma                              |                                                                          |             
      Leukemia Mononuclear                 |                                  X                                       |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Leukemia Mononuclear                 |                                  X                                       |             
      Pheochromocytoma Benign              |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +     +  +  +        +  +  +  +     +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  M  +  M  +|             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               | X  X                                X  X     X  X  X     X     X  X  X   |             
      Pars Distalis, Adenoma, Multiple     |       X                                                                  |             
      Pars Distalis, Leukemia Mononuclear  |                                  X                                       |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Adenoma                      |                X                                                         |             
      C-Cell, Carcinoma                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05061-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 17:56:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 2| 7| 7| 6| 4| 2| 7| 7| 6| 6| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2|             
                             DAY ON TEST   | 3| 3| 3| 0| 7| 3| 3| 5| 6| 7| 3| 3| 5| 4| 8| 3| 3| 3| 3| 1| 3| 3| 3| 3| 8|             
                                           | 6| 6| 6| 4| 9| 6| 6| 6| 2| 9| 4| 1| 8| 2| 1| 4| 4| 5| 5| 9| 4| 4| 4| 5| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    UNTREATE                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    D 71UF                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM - cont                |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
      Sarcoma                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                             X  X         |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granulosa Cell Tumor Benign          |                   X                                                      |             
      Leukemia Mononuclear                 |                                  X                                       |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma                       |                                                                          |             
      Hemangioma                           |                                              X                           |             
      Leukemia Mononuclear                 |                                  X                                       |             
      Polyp Stromal                        | X                    X                                X        X         |             
      Polyp Stromal, Multiple              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +        M              M              +                             +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                  X                                       |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                X                 X                                       |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                  X                                       |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Adenocarcinoma                       |                                                                          |             
      Fibroadenoma                         |       X  X        X              X                    X           X  X   |             
      Fibroadenoma, Multiple               | X                                                           X  X         |             
      Fibroma                              | X                                                                        |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Squamous Cell Papilloma              | X                                                                        |             
      Subcutaneous Tissue, Fibroma         |                   X                                                      |             
      Subcutaneous Tissue, Sarcoma         |          X                                                               |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   6                                                               
NTP Experiment-Test: 05061-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 17:56:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 2| 7| 7| 6| 4| 2| 7| 7| 6| 6| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2|             
                             DAY ON TEST   | 3| 3| 3| 0| 7| 3| 3| 5| 6| 7| 3| 3| 5| 4| 8| 3| 3| 3| 3| 1| 3| 3| 3| 3| 8|             
                                           | 6| 6| 6| 4| 9| 6| 6| 6| 2| 9| 4| 1| 8| 2| 1| 4| 4| 5| 5| 9| 4| 4| 4| 5| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    UNTREATE                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    D 71UF                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                  X                                       |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                                                          |             
      Leukemia Mononuclear                 |                                  X                                       |             
      Sarcoma, Metastatic, Thymus          |          X                                                               |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                  X                                       |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |             M              M                                            M|             
                                            __________________________________________________________________________|             
   Eye                                     |                      +           +        M  +        +  +  +            |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                        +                                 |             
      Squamous Cell Carcinoma              |                                        X                                 |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                  X              X                        |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                  X                                       |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                X                 X              X  X                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   7                                                               
NTP Experiment-Test: 05061-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 17:56:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 4| 4| 2| 7| 7| 6| 4| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 2|              |            |
                             DAY ON TEST   | 3| 0| 6| 6| 8| 3| 3| 2| 6| 6| 3| 3| 3| 1| 6| 3| 3| 3| 3| 7|              |            |
                                           | 4| 8| 2| 2| 1| 6| 5| 0| 4| 2| 6| 6| 6| 6| 2| 6| 6| 5| 5| 9|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|              |     A      |
    UNTREATE                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|              |     L      |
    D 71UF                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +               |  69        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  69        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  68        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  69        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Leukemia Mononuclear                 |                      X                 X     X                           |          9 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                      +                                                   |   4        |
      Leukemia Mononuclear                 |                      X                                                   |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Leukemia Mononuclear                 |                      X                                                   |          2 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +               |  69        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Leukemia Mononuclear                 |                      X                                                   |          1 |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
      Leukemia Mononuclear                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Leukemia Mononuclear                 |                      X                                                   |          3 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +               |  67        |
      Adenoma                              |    X                                                                     |          2 |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +               |  67        |
      Leukemia Mononuclear                 |                                                                          |          2 |
      Pheochromocytoma Benign              |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +           +  +  +        +  +  +  +     +  +  +  +                  |  50        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +               |  63        |
      Adenoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Pars Distalis, Adenoma               | X              X  X           X        X     X                           |         29 |
      Pars Distalis, Adenoma, Multiple     |                                                 X  X  X                  |          5 |
      Pars Distalis, Leukemia Mononuclear  |                                                                          |          2 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page   8                                                               
NTP Experiment-Test: 05061-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 17:56:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 4| 4| 2| 7| 7| 6| 4| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 2|              |            |
                             DAY ON TEST   | 3| 0| 6| 6| 8| 3| 3| 2| 6| 6| 3| 3| 3| 1| 6| 3| 3| 3| 3| 7|              |            |
                                           | 4| 8| 2| 2| 1| 6| 5| 0| 4| 2| 6| 6| 6| 6| 2| 6| 6| 5| 5| 9|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|              |     A      |
    UNTREATE                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|              |     L      |
    D 71UF                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      C-Cell, Adenoma                      |                                                                          |          5 |
      C-Cell, Carcinoma                    |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   2        |
      Sarcoma                              |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +               |  65        |
      Adenoma                              |    X                                                                     |          5 |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Granulosa Cell Tumor Benign          |                                                                          |          1 |
      Leukemia Mononuclear                 |                      X                                                   |          3 |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Adenocarcinoma                       |                                                                          |          1 |
      Hemangioma                           |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Polyp Stromal                        |                                                                          |          8 |
      Polyp Stromal, Multiple              |                X                                                         |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |             +                             +              M               |   7        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  +               |  66        |
      Leukemia Mononuclear                 |                      X                                                   |          3 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Leukemia Mononuclear                 |                      X                                                   |          2 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Leukemia Mononuclear                 |                      X                 X     X                           |          7 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +               |  62        |
      Leukemia Mononuclear                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +               |  65        |
      Adenocarcinoma                       |                   X                                                      |          2 |
      Fibroadenoma                         |                               X     X        X                           |         18 |
      Fibroadenoma, Multiple               |                                                                          |          4 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page   9                                                               
NTP Experiment-Test: 05061-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 17:56:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 4| 4| 2| 7| 7| 6| 4| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 2|              |            |
                             DAY ON TEST   | 3| 0| 6| 6| 8| 3| 3| 2| 6| 6| 3| 3| 3| 1| 6| 3| 3| 3| 3| 7|              |            |
                                           | 4| 8| 2| 2| 1| 6| 5| 0| 4| 2| 6| 6| 6| 6| 2| 6| 6| 5| 5| 9|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|              |     A      |
    UNTREATE                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|              |     L      |
    D 71UF                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Fibroma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Squamous Cell Papilloma              |                                                                          |          1 |
      Subcutaneous Tissue, Fibroma         |                                                       X                  |          2 |
      Subcutaneous Tissue, Sarcoma         |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Leukemia Mononuclear                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Alveolar/Bronchiolar Adenoma         |                                        X                                 |          1 |
      Leukemia Mononuclear                 |                      X                                                   |          3 |
      Sarcoma, Metastatic, Thymus          |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |             M                                            M               |            |
                                            __________________________________________________________________________|____________|
   Eye                                     | +  +                                                                     |  13        |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
      Squamous Cell Carcinoma              |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Leukemia Mononuclear                 |                      X                                                   |          4 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Leukemia Mononuclear                 |                                                                          |          2 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Leukemia Mononuclear                 |                      X                 X     X                           |          9 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  10                                                               
NTP Experiment-Test: 05061-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 17:56:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 2| 7| 7| 7| 6| 2| 7| 7| 7| 2| 2| 7| 7| 7| 7| 6| 7| 6| 6| 2| 2|             
                             DAY ON TEST   | 3| 3| 1| 0| 8| 3| 3| 3| 1| 8| 3| 3| 3| 8| 8| 3| 3| 3| 3| 5| 3| 8| 6| 8| 8|             
                                           | 4| 4| 6| 0| 1| 4| 4| 4| 1| 1| 4| 4| 4| 1| 1| 4| 4| 0| 0| 9| 4| 9| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0.2%                                   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    71LF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma, Multiple             |                               X                                          |             
      Polyp Adenomatous, Multiple          |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma                       |                                                                          |             
      Polyp Adenomatous                    |       X        X                 X                    X                  |             
      Polyp Adenomatous, Multiple          | X                 X  X              X        X  X           X  X         |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Carcinoma             |                               X  X                                       |             
      Hepatocellular Carcinoma, Multiple   |                      X                                                   |             
      Hepatocellular Adenoma               |    X     X        X           X                                X         |             
      Hepatocellular Adenoma, Multiple     | X                       X           X        X     X  X  X               |             
      Leukemia Mononuclear                 |                                                                X         |             
                                            __________________________________________________________________________|             
   Mesentery                               |             M  +           M           M  M                          M  M|             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                X         |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                                       +                  |             
      Palate, Squamous Cell Papilloma,     |                                                                          |             
           Multiple                        |                                                       X                  |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Squamous Cell Carcinoma              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                X         |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |    X                                                                     |             
      Leukemia Mononuclear                 |                                                                X         |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                X         |             
      Pheochromocytoma Benign              |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +  +  +  +  +      |             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  11                                                               
NTP Experiment-Test: 05061-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 17:56:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 2| 7| 7| 7| 6| 2| 7| 7| 7| 2| 2| 7| 7| 7| 7| 6| 7| 6| 6| 2| 2|             
                             DAY ON TEST   | 3| 3| 1| 0| 8| 3| 3| 3| 1| 8| 3| 3| 3| 8| 8| 3| 3| 3| 3| 5| 3| 8| 6| 8| 8|             
                                           | 4| 4| 6| 0| 1| 4| 4| 4| 1| 1| 4| 4| 4| 1| 1| 4| 4| 0| 0| 9| 4| 9| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0.2%                                   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    71LF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               | X     X              X                       X  X                 X      |             
      Pars Distalis, Adenoma, Multiple     |                                                             X            |             
      Pars Distalis, Leukemia Mononuclear  |                                                                X         |             
      Pars Intermedia, Adenoma             |          X                                                               |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                X         |             
      C-Cell, Adenoma                      |    X              X  X                          X     X                  |             
      Follicular Cell, Adenoma             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                   +                                                      |             
      Basosquamous Tumor Malignant         |                   X                                                      |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granulosa Cell Tumor Benign          |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Polyp Stromal                        |       X  X     X                                   X  X        X         |             
      Polyp Stromal, Multiple              |                                  X                                       |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |             +  +           +        +  +  +                 +            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                X         |             
      Lipoma                               |                                                             X            |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  M  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  M  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  M  +  M  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  M  M|             
      Fibroadenoma                         |                X              X                                          |             
      Fibroadenoma, Multiple               | X                                                        X               |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Subcutaneous Tissue, Fibroma         |                                  X                                       |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basosquamous Tumor Malignant,        |                                                                          |             
          Metastatic, Tissue NOS           |                   X                                                      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  12                                                               
NTP Experiment-Test: 05061-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 17:56:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 2| 7| 7| 7| 6| 2| 7| 7| 7| 2| 2| 7| 7| 7| 7| 6| 7| 6| 6| 2| 2|             
                             DAY ON TEST   | 3| 3| 1| 0| 8| 3| 3| 3| 1| 8| 3| 3| 3| 8| 8| 3| 3| 3| 3| 5| 3| 8| 6| 8| 8|             
                                           | 4| 4| 6| 0| 1| 4| 4| 4| 1| 1| 4| 4| 4| 1| 1| 4| 4| 0| 0| 9| 4| 9| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0.2%                                   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    71LF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Rhabdomyosarcoma                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                X         |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                                                          |             
      Alveolar/Bronchiolar Adenoma,        |                                                                          |             
          Multiple                         |                                                                          |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                          |             
      Leukemia Mononuclear                 |                                                                X         |             
      Squamous Cell Carcinoma              |                                  X                                       |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                   +     +                             +           +      |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                X         |             
      Pelvis, Transitional Epithelium,     |                                                                          |             
           Carcinoma                       |                      X                                                   |             
      Renal Tubule, Adenoma                |          X              X                             X                  |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Transitional Epithelium, Papilloma   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                X         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  13                                                               
NTP Experiment-Test: 05061-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 17:56:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 2| 2| 7| 7| 7| 6| 2| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2|            |
                             DAY ON TEST   | 3| 3| 3| 8| 8| 3| 3| 3| 7| 7| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7|            |
                                           | 4| 4| 4| 1| 1| 4| 4| 3| 0| 9| 3| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|     A      |
    0.2%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|     L      |
    71LF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Adenocarcinoma, Multiple             |                                                                          |          1 |
      Polyp Adenomatous, Multiple          |                                                                X         |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Adenocarcinoma                       | X                                                                        |          1 |
      Polyp Adenomatous                    |                X  X  X  X           X                 X                  |         10 |
      Polyp Adenomatous, Multiple          | X                             X        X  X     X  X        X     X  X   |         17 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hepatocellular Carcinoma             |       X        X                                               X         |          5 |
      Hepatocellular Carcinoma, Multiple   |    X              X  X                 X           X     X               |          7 |
      Hepatocellular Adenoma               |                                        X           X  X     X  X         |         10 |
      Hepatocellular Adenoma, Multiple     | X  X              X  X        X  X  X     X  X  X                 X      |         18 |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |          M  M              M  +           +                 +  +     +  M|   6        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pharynx                                 |                                                                          |   1        |
      Palate, Squamous Cell Papilloma,     |                                                                          |            |
           Multiple                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Squamous Cell Carcinoma              |       X                                                                  |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                              +                           |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Adenoma                              |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  14                                                               
NTP Experiment-Test: 05061-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 17:56:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 2| 2| 7| 7| 7| 6| 2| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2|            |
                             DAY ON TEST   | 3| 3| 3| 8| 8| 3| 3| 3| 7| 7| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7|            |
                                           | 4| 4| 4| 1| 1| 4| 4| 3| 0| 9| 3| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|     A      |
    0.2%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|     L      |
    71LF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Pheochromocytoma Benign              | X  X                             X                                       |          3 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +        +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  40        |
      Adenoma                              |                      X                                                   |          1 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Pars Distalis, Adenoma               | X     X        X     X        X  X           X           X  X     X      |         16 |
      Pars Distalis, Adenoma, Multiple     |                                                 X     X                  |          3 |
      Pars Distalis, Leukemia Mononuclear  |                                                                          |          1 |
      Pars Intermedia, Adenoma             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      C-Cell, Adenoma                      |                                                                          |          5 |
      Follicular Cell, Adenoma             |                                  X                                       |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
      Basosquamous Tumor Malignant         |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | M  +  M  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|  46        |
      Adenoma                              |                   X                             X        X               |          3 |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Granulosa Cell Tumor Benign          |                                                                      X   |          1 |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Polyp Stromal                        |    X  X                 X     X                 X     X                  |         12 |
      Polyp Stromal, Multiple              |                                     X                             X      |          3 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |             +              +                                   +     +  M|  11        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Lipoma                               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  +  M  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  41        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  15                                                               
NTP Experiment-Test: 05061-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 17:56:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 2| 2| 7| 7| 7| 6| 2| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2|            |
                             DAY ON TEST   | 3| 3| 3| 8| 8| 3| 3| 3| 7| 7| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7|            |
                                           | 4| 4| 4| 1| 1| 4| 4| 3| 0| 9| 3| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|     A      |
    0.2%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|     L      |
    71LF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  M  +  M  +  +  +  +  +  +  M  M  +  +  +  +  +  +  M  +  +  +  +  M  +|  38        |
      Fibroadenoma                         |                X                    X     X  X     X        X            |          8 |
      Fibroadenoma, Multiple               |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Subcutaneous Tissue, Fibroma         |                         X                                                |          2 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basosquamous Tumor Malignant,        |                                                                          |            |
          Metastatic, Tissue NOS           |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         | +                                                                        |   1        |
      Rhabdomyosarcoma                     | X                                                                        |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Alveolar/Bronchiolar Adenoma         |    X                                X                                    |          2 |
      Alveolar/Bronchiolar Adenoma,        |                                                                          |            |
          Multiple                         |                                                    X                     |          1 |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |                                                          X               |          1 |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Squamous Cell Carcinoma              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                     +                    +        +      |   7        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Pelvis, Transitional Epithelium,     |                                                                          |            |
           Carcinoma                       |                                                                          |          1 |
      Renal Tubule, Adenoma                |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Transitional Epithelium, Papilloma   |                   X                                            X         |          2 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  16                                                               
NTP Experiment-Test: 05061-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 17:56:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 2| 2| 7| 7| 7| 6| 2| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2|            |
                             DAY ON TEST   | 3| 3| 3| 8| 8| 3| 3| 3| 7| 7| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7|            |
                                           | 4| 4| 4| 1| 1| 4| 4| 3| 0| 9| 3| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|     A      |
    0.2%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|     L      |
    71LF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Leukemia Mononuclear                 |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  17                                                               
NTP Experiment-Test: 05061-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 17:56:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 7| 2| 7| 7| 7| 7| 2| 7| 7| 7| 7| 2| 7| 7| 7| 6| 2|             
                             DAY ON TEST   | 2| 2| 2| 2| 6| 2| 2| 2| 2| 8| 2| 2| 2| 2| 7| 3| 3| 3| 1| 7| 3| 3| 3| 4| 8|             
                                           | 9| 9| 9| 9| 7| 9| 9| 9| 9| 1| 9| 9| 9| 9| 9| 0| 0| 0| 9| 9| 0| 0| 0| 9| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    0.5%                                   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    71MLF                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma                       |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
      Polyp Adenomatous                    |                                                                          |             
      Polyp Adenomatous, Multiple          |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma                       |                   X              X  X           X              X         |             
      Adenocarcinoma, Multiple             |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
      Polyp Adenomatous                    |                         X        X                    X                  |             
      Polyp Adenomatous, Multiple          | X  X  X  X     X  X  X        X     X  X     X  X  X        X  X  X  X   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Polyp Adenomatous                    |                                                             X            |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leiomyoma                            |                                                                   X      |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Carcinoma             |                                                                      X   |             
      Hepatocellular Carcinoma, Multiple   | X  X  X  X  X     X  X  X     X  X  X  X     X  X  X  X     X  X  X      |             
      Hepatocellular Adenoma               |       X        X                                               X         |             
      Hepatocellular Adenoma, Multiple     |             X     X     X     X        X     X  X  X  X           X  X   |             
      Hepatocholangiocarcinoma             |                X  X  X        X                             X     X      |             
      Hepatocholangiocarcinoma, Multiple   |                                                                          |             
      Hepatocholangioma                    |                X                                                         |             
      Hepatocholangioma, Multiple          |                                        X                                 |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Squamous Cell Carcinoma              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  18                                                               
NTP Experiment-Test: 05061-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 17:56:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 7| 2| 7| 7| 7| 7| 2| 7| 7| 7| 7| 2| 7| 7| 7| 6| 2|             
                             DAY ON TEST   | 2| 2| 2| 2| 6| 2| 2| 2| 2| 8| 2| 2| 2| 2| 7| 3| 3| 3| 1| 7| 3| 3| 3| 4| 8|             
                                           | 9| 9| 9| 9| 7| 9| 9| 9| 9| 1| 9| 9| 9| 9| 9| 0| 0| 0| 9| 9| 0| 0| 0| 9| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    0.5%                                   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    71MLF                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
           Liver                           |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Pheochromocytoma Complex             |                                                                          |             
      Pheochromocytoma Benign              |                                                             X            |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               |    X  X        X                    X  X     X     X  X                  |             
      Pars Distalis, Adenoma, Multiple     | X                             X                 X                        |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      C-Cell, Adenoma                      |       X        X                       X                                 |             
      C-Cell, Carcinoma                    | X                                                                        |             
      Follicular Cell, Adenoma             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
      Neoplasm NOS                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Adenoma                              |                   X                                                      |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Polyp Stromal                        |    X  X                                X  X                              |             
      Sarcoma Stromal                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +        +        +  +  +  +  +  +  +     M              M  +  +  +     M|             
      Mediastinal, Leukemia Mononuclear    |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  19                                                               
NTP Experiment-Test: 05061-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 17:56:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 7| 2| 7| 7| 7| 7| 2| 7| 7| 7| 7| 2| 7| 7| 7| 6| 2|             
                             DAY ON TEST   | 2| 2| 2| 2| 6| 2| 2| 2| 2| 8| 2| 2| 2| 2| 7| 3| 3| 3| 1| 7| 3| 3| 3| 4| 8|             
                                           | 9| 9| 9| 9| 7| 9| 9| 9| 9| 1| 9| 9| 9| 9| 9| 0| 0| 0| 9| 9| 0| 0| 0| 9| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    0.5%                                   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    71MLF                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  M  M  +  M  +  +  M  M  +  M  +  M  +  +  +  +  +|             
      Fibroadenoma                         |          X        X                 X                                    |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Squamous Cell Papilloma              |       X                                                                  |             
      Pinna, Granular Cell Tumor Benign    |                                                                   X      |             
      Pinna, Squamous Cell Papilloma       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                                                          |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |       X  X                       X     X        X                        |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                   +  +   |             
      Internal Ear, Leukemia Mononuclear   |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                    +              +      |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                      +   |             
      Adenoma                              |                                                                          |             
      Carcinoma                            |                                                                      X   |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  20                                                               
NTP Experiment-Test: 05061-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 17:56:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 7| 2| 7| 7| 7| 7| 2| 7| 7| 7| 7| 2| 7| 7| 7| 6| 2|             
                             DAY ON TEST   | 2| 2| 2| 2| 6| 2| 2| 2| 2| 8| 2| 2| 2| 2| 7| 3| 3| 3| 1| 7| 3| 3| 3| 4| 8|             
                                           | 9| 9| 9| 9| 7| 9| 9| 9| 9| 1| 9| 9| 9| 9| 9| 0| 0| 0| 9| 9| 0| 0| 0| 9| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    0.5%                                   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    71MLF                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Urinary Bladder                 |          X                                                               |             
      Renal Tubule, Adenoma                |          X                    X                                          |             
      Renal Tubule, Adenoma, Multiple      |                         X                       X           X            |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Transitional Epithelium, Carcinoma   |                                                                          |             
      Transitional Epithelium, Papilloma   |    X              X           X                                          |             
      Transitional Epithelium, Papilloma,  |                                                                          |             
           Multiple                        |                                                                          |             
      Transitional Epithelium, Squamous    |                                                                          |             
          Cell Carcinoma                   |          X                                                               |             
      Transitional Epithelium, Squamous    |                                                                          |             
          Cell Papilloma                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  21                                                               
NTP Experiment-Test: 05061-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 17:56:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 2| 7| 7| 6| 6| 6| 7| 6| 5| 2| 2| 7| 7| 6| 6| 2| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 3| 3| 3| 1| 8| 3| 3| 9| 7| 0| 3| 9| 8| 8| 7| 3| 3| 6| 4| 7| 3| 3| 3| 3| 3|             
                                           | 0| 0| 0| 6| 1| 0| 0| 6| 0| 6| 0| 1| 2| 1| 9| 0| 0| 0| 2| 9| 0| 0| 0| 0| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    0.5%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    71MLF                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Leukemia Mononuclear                 |                                                       X                  |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma                       |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
      Polyp Adenomatous                    |                                                                          |             
      Polyp Adenomatous, Multiple          |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma                       |    X     X     X  X        X  X                    X  X                  |             
      Adenocarcinoma, Multiple             |       X                                                                  |             
      Leukemia Mononuclear                 |                                                       X                  |             
      Polyp Adenomatous                    |    X                       X                                             |             
      Polyp Adenomatous, Multiple          | X     X        X  X  X  X     X  X  X        X  X  X        X  X  X  X   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Polyp Adenomatous                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leiomyoma                            |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Carcinoma             |                         X                             X           X     X|             
      Hepatocellular Carcinoma, Multiple   | X  X  X  X     X  X  X        X  X  X        X  X  X        X  X     X   |             
      Hepatocellular Adenoma               |          X        X                                   X                  |             
      Hepatocellular Adenoma, Multiple     | X  X  X        X     X        X  X  X        X  X  X        X  X  X  X  X|             
      Hepatocholangiocarcinoma             |                   X           X                                          |             
      Hepatocholangiocarcinoma, Multiple   |                         X                                                |             
      Hepatocholangioma                    |                                                                          |             
      Hepatocholangioma, Multiple          |                                                                          |             
      Leukemia Mononuclear                 |          X        X        X                          X                  |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |       X                          X                                       |             
      Leukemia Mononuclear                 |          X                                            X                  |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Squamous Cell Carcinoma              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  22                                                               
NTP Experiment-Test: 05061-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 17:56:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 2| 7| 7| 6| 6| 6| 7| 6| 5| 2| 2| 7| 7| 6| 6| 2| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 3| 3| 3| 1| 8| 3| 3| 9| 7| 0| 3| 9| 8| 8| 7| 3| 3| 6| 4| 7| 3| 3| 3| 3| 3|             
                                           | 0| 0| 0| 6| 1| 0| 0| 6| 0| 6| 0| 1| 2| 1| 9| 0| 0| 0| 2| 9| 0| 0| 0| 0| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    0.5%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    71MLF                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
           Liver                           |                                                                         X|             
      Leukemia Mononuclear                 |          X                                            X                  |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                            X                          X                  |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X                 X                          X                  |             
      Pheochromocytoma Complex             |                                                    X                     |             
      Pheochromocytoma Benign              |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +     +  +  +  +  +  +  +  +        +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               | X     X  X           X           X                    X     X  X        X|             
      Pars Distalis, Adenoma, Multiple     |                                                    X                 X   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X                                            X                  |             
      C-Cell, Adenoma                      |                                                 X                        |             
      C-Cell, Carcinoma                    |                                                                          |             
      Follicular Cell, Adenoma             |                                  X                                       |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              | +                                                                        |             
      Neoplasm NOS                         | X                                                                        |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                      X                                                   |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                          |             
      Leukemia Mononuclear                 |                                                       X                  |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Polyp Stromal                        |    X                                                                     |             
      Sarcoma Stromal                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                   X        X                                             |             
                                            __________________________________________________________________________|             
   Lymph Node                              |             +     +        +  +     +  M  +  +  +        M  +  +         |             
      Mediastinal, Leukemia Mononuclear    |                            X                                             |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  23                                                               
NTP Experiment-Test: 05061-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 17:56:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 2| 7| 7| 6| 6| 6| 7| 6| 5| 2| 2| 7| 7| 6| 6| 2| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 3| 3| 3| 1| 8| 3| 3| 9| 7| 0| 3| 9| 8| 8| 7| 3| 3| 6| 4| 7| 3| 3| 3| 3| 3|             
                                           | 0| 0| 0| 6| 1| 0| 0| 6| 0| 6| 0| 1| 2| 1| 9| 0| 0| 0| 2| 9| 0| 0| 0| 0| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    0.5%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    71MLF                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                            X                                             |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                          |             
      Leukemia Mononuclear                 |          X        X        X                          X                  |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M|             
      Leukemia Mononuclear                 |                                                       X                  |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +|             
      Fibroadenoma                         |                                     X        X                    X      |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                   X                                                      |             
      Squamous Cell Papilloma              |                                                                          |             
      Pinna, Granular Cell Tumor Benign    |                                                                          |             
      Pinna, Squamous Cell Papilloma       |                X                                                  X      |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                       X                  |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                                                          |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |          X        X           X              X  X              X        X|             
      Leukemia Mononuclear                 |          X                 X                          X                  |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                +                                   +  +        +  +      |             
      Internal Ear, Leukemia Mononuclear   |                                                       X                  |             
                                            __________________________________________________________________________|             
   Eye                                     |    +           +  +                                                      |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                +         |             
      Adenoma                              |                                                                X         |             
      Carcinoma                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  24                                                               
NTP Experiment-Test: 05061-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 17:56:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 2| 7| 7| 6| 6| 6| 7| 6| 5| 2| 2| 7| 7| 6| 6| 2| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 3| 3| 3| 1| 8| 3| 3| 9| 7| 0| 3| 9| 8| 8| 7| 3| 3| 6| 4| 7| 3| 3| 3| 3| 3|             
                                           | 0| 0| 0| 6| 1| 0| 0| 6| 0| 6| 0| 1| 2| 1| 9| 0| 0| 0| 2| 9| 0| 0| 0| 0| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    0.5%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    71MLF                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Leukemia Mononuclear                 |          X                                            X                  |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Urinary Bladder                 |                                                                          |             
      Renal Tubule, Adenoma                |                   X  X  X                                      X         |             
      Renal Tubule, Adenoma, Multiple      |                                  X                                       |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Transitional Epithelium, Carcinoma   |    X           X  X  X  X                                                |             
      Transitional Epithelium, Papilloma   | X                                X                                       |             
      Transitional Epithelium, Papilloma,  |                                                                          |             
           Multiple                        |                               X                                          |             
      Transitional Epithelium, Squamous    |                                                                          |             
          Cell Carcinoma                   |                                                                          |             
      Transitional Epithelium, Squamous    |                                                                          |             
          Cell Papilloma                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X        X        X                          X                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  25                                                               
NTP Experiment-Test: 05061-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 17:56:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 5| 7| 7| 7| 6| 2| 7| 7| 7| 6| 6| 7| 7| 6| 6| 2|              |            |
                             DAY ON TEST   | 2| 2| 1| 0| 7| 3| 3| 0| 9| 7| 3| 3| 2| 4| 0| 2| 2| 6| 4| 8|              |            |
                                           | 9| 9| 4| 9| 5| 0| 0| 8| 5| 9| 0| 0| 5| 9| 1| 9| 9| 0| 7| 1|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     A      |
    0.5%                                   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|              |     L      |
    71MLF                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +               |  67        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  69        |
      Adenocarcinoma                       |          X                       X                                       |          2 |
      Leukemia Mononuclear                 |                                           X                              |          1 |
      Polyp Adenomatous                    |                               X                                          |          1 |
      Polyp Adenomatous, Multiple          |                                     X                                    |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Adenocarcinoma                       |                X                       X     X  X  X                     |         18 |
      Adenocarcinoma, Multiple             |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Polyp Adenomatous                    |                                     X  X  X                              |          8 |
      Polyp Adenomatous, Multiple          | X  X  X        X  X  X        X  X           X  X  X  X                  |         45 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Leukemia Mononuclear                 |                                           X                              |          1 |
      Polyp Adenomatous                    |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  69        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  69        |
      Leukemia Mononuclear                 |                                           X                              |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +               |  69        |
      Leiomyoma                            |                                                                          |          1 |
      Leukemia Mononuclear                 |                                           X                              |          1 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Hepatocellular Carcinoma             |             X                                                            |          6 |
      Hepatocellular Carcinoma, Multiple   | X  X  X        X  X  X  X     X  X  X  X  X  X  X  X  X                  |         51 |
      Hepatocellular Adenoma               |          X                       X                                       |          8 |
      Hepatocellular Adenoma, Multiple     |    X        X  X  X  X  X           X  X     X  X  X  X                  |         39 |
      Hepatocholangiocarcinoma             |       X        X                                                         |         10 |
      Hepatocholangiocarcinoma, Multiple   |                                                                          |          1 |
      Hepatocholangioma                    |                                                                          |          1 |
      Hepatocholangioma, Multiple          |                                                                          |          1 |
      Leukemia Mononuclear                 |                                           X                              |          5 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                      +                                                   |   1        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Adenoma                              |                                                                          |          2 |
      Leukemia Mononuclear                 |                                           X                              |          3 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Squamous Cell Carcinoma              |       X                                                                  |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  26                                                               
NTP Experiment-Test: 05061-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 17:56:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 5| 7| 7| 7| 6| 2| 7| 7| 7| 6| 6| 7| 7| 6| 6| 2|              |            |
                             DAY ON TEST   | 2| 2| 1| 0| 7| 3| 3| 0| 9| 7| 3| 3| 2| 4| 0| 2| 2| 6| 4| 8|              |            |
                                           | 9| 9| 4| 9| 5| 0| 0| 8| 5| 9| 0| 0| 5| 9| 1| 9| 9| 0| 7| 1|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     A      |
    0.5%                                   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|              |     L      |
    71MLF                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |                                                                          |          1 |
      Leukemia Mononuclear                 |                                           X                              |          3 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  69        |
      Leukemia Mononuclear                 |                                           X                              |          3 |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  69        |
      Leukemia Mononuclear                 |                                                                          |          3 |
      Pheochromocytoma Complex             |                                                                          |          1 |
      Pheochromocytoma Benign              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +                  |  60        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +               |  67        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Pars Distalis, Adenoma               | X     X     X        X           X  X  X           X                     |         25 |
      Pars Distalis, Adenoma, Multiple     |    X                          X                                          |          7 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Leukemia Mononuclear                 |                                                                          |          2 |
      C-Cell, Adenoma                      |       X                                                                  |          5 |
      C-Cell, Carcinoma                    |                                                                          |          1 |
      Follicular Cell, Adenoma             |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
      Neoplasm NOS                         |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +               |  68        |
      Adenoma                              |                                                 X                        |          3 |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |                                                 X                        |          1 |
      Leukemia Mononuclear                 |                                           X                              |          2 |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Leukemia Mononuclear                 |                                           X                              |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  27                                                               
NTP Experiment-Test: 05061-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 17:56:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 5| 7| 7| 7| 6| 2| 7| 7| 7| 6| 6| 7| 7| 6| 6| 2|              |            |
                             DAY ON TEST   | 2| 2| 1| 0| 7| 3| 3| 0| 9| 7| 3| 3| 2| 4| 0| 2| 2| 6| 4| 8|              |            |
                                           | 9| 9| 4| 9| 5| 0| 0| 8| 5| 9| 0| 0| 5| 9| 1| 9| 9| 0| 7| 1|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     A      |
    0.5%                                   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|              |     L      |
    71MLF                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Polyp Stromal                        |                      X        X           X                              |          8 |
      Sarcoma Stromal                      |                                  X                                       |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Leukemia Mononuclear                 |                                           X                              |          3 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |    +           +  +        M              +  +  +        M               |  28        |
      Mediastinal, Leukemia Mononuclear    |                                           X                              |          2 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  66        |
      Leukemia Mononuclear                 |                                           X                              |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  69        |
      Leukemia Mononuclear                 |                                           X                              |          2 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |       X                                                                  |          1 |
      Leukemia Mononuclear                 |                                           X                              |          5 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  I  +  +  +  +  +  +  +  +  +  M  M  +  +  +  M  +               |  61        |
      Leukemia Mononuclear                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  M  +  +  +  +               |  54        |
      Fibroadenoma                         | X                    X                 X                                 |          9 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Squamous Cell Papilloma              |                                                                          |          1 |
      Pinna, Granular Cell Tumor Benign    |                                                                          |          1 |
      Pinna, Squamous Cell Papilloma       |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Leukemia Mononuclear                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Alveolar/Bronchiolar Adenoma         |                                                       X                  |          1 |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  28                                                               
NTP Experiment-Test: 05061-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 17:56:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 5| 7| 7| 7| 6| 2| 7| 7| 7| 6| 6| 7| 7| 6| 6| 2|              |            |
                             DAY ON TEST   | 2| 2| 1| 0| 7| 3| 3| 0| 9| 7| 3| 3| 2| 4| 0| 2| 2| 6| 4| 8|              |            |
                                           | 9| 9| 4| 9| 5| 0| 0| 8| 5| 9| 0| 0| 5| 9| 1| 9| 9| 0| 7| 1|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     A      |
    0.5%                                   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|              |     L      |
    71MLF                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
           Liver                           |    X  X        X     X        X     X        X  X  X  X                  |         22 |
      Leukemia Mononuclear                 |                                           X                              |          4 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                +                                                         |   8        |
      Internal Ear, Leukemia Mononuclear   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                           +  +                           |   7        |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   2        |
      Adenoma                              |                                                                          |          1 |
      Carcinoma                            |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Leukemia Mononuclear                 |                                           X                              |          3 |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Urinary Bladder                 |                                                                          |          1 |
      Renal Tubule, Adenoma                | X                 X              X        X        X                     |         11 |
      Renal Tubule, Adenoma, Multiple      |                                              X                           |          5 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Transitional Epithelium, Carcinoma   |    X                          X                 X                        |          8 |
      Transitional Epithelium, Papilloma   | X                                                                        |          6 |
      Transitional Epithelium, Papilloma,  |                                                                          |            |
           Multiple                        |                                                                          |          1 |
      Transitional Epithelium, Squamous    |                                                                          |            |
          Cell Carcinoma                   |                                                                          |          1 |
      Transitional Epithelium, Squamous    |                                                                          |            |
          Cell Papilloma                   |                X                                                         |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Leukemia Mononuclear                 |                                           X                              |          5 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  29                                                               
NTP Experiment-Test: 05061-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 17:56:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 5| 2| 7| 7| 7| 6| 4| 7| 6| 6| 4| 4| 7| 7| 6| 5| 4| 7| 6| 6| 5| 4|             
                             DAY ON TEST   | 2| 2| 9| 6| 7| 2| 2| 0| 1| 6| 2| 8| 6| 6| 6| 2| 2| 7| 6| 1| 0| 3| 1| 8| 6|             
                                           | 9| 9| 5| 6| 9| 9| 9| 2| 6| 4| 0| 5| 2| 2| 2| 9| 2| 4| 9| 8| 2| 8| 0| 0| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    1.0%                                   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    71MHF                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +     +  +  +        +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +     +  +  +        +  +  +  +  +  +  +  +  +   |             
      Adenocarcinoma                       |                                                 X                        |             
      Polyp Adenomatous                    |                                                                          |             
      Polyp Adenomatous, Multiple          |                                                 X                        |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma                       | X                                            X                           |             
      Adenocarcinoma, Multiple             |                                                                          |             
      Polyp Adenomatous                    |          X              X                       X     X                  |             
      Polyp Adenomatous, Multiple          | X  X  X        X  X           X  X  X        X     X        X  X  X  X   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +     +  +  +        +  +  +  +  +  +  +  +  A   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +     +  +  +        +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +     +  +  +        +  +  +  +  +  +  +  +  A   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  M  +     +  +  +        +  +  +  +  +  +  +  +  A   |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cholangioma                          |                                                                          |             
      Hepatocellular Carcinoma             |                                        X                                 |             
      Hepatocellular Carcinoma, Multiple   | X  X  X  X     X  X  X  X     X  X  X        X  X  X  X     X  X  X  X   |             
      Hepatocellular Adenoma               |                X  X  X                                   X        X     X|             
      Hepatocellular Adenoma, Multiple     |          X              X  X        X        X  X     X     X        X   |             
      Hepatocholangiocarcinoma             |    X  X           X              X  X        X                           |             
      Hepatocholangiocarcinoma, Multiple   |                                                                X         |             
      Leukemia Mononuclear                 |                                     X                                    |             
                                            __________________________________________________________________________|             
   Mesentery                               | +  +        M                                                            |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           | X  X                                                                     |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +   |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           | X                                                                        |             
      Leukemia Mononuclear                 |                                     X                                    |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +     +  +  +        +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Squamous Cell Carcinoma              |                                                                          |             
      Squamous Cell Papilloma              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
      Squamous Cell Papilloma              |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Gingiva, Squamous Cell Carcinoma     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  30                                                               
NTP Experiment-Test: 05061-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 17:56:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 5| 2| 7| 7| 7| 6| 4| 7| 6| 6| 4| 4| 7| 7| 6| 5| 4| 7| 6| 6| 5| 4|             
                             DAY ON TEST   | 2| 2| 9| 6| 7| 2| 2| 0| 1| 6| 2| 8| 6| 6| 6| 2| 2| 7| 6| 1| 0| 3| 1| 8| 6|             
                                           | 9| 9| 5| 6| 9| 9| 9| 2| 6| 4| 0| 5| 2| 2| 2| 9| 2| 4| 9| 8| 2| 8| 0| 0| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    1.0%                                   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    71MHF                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +     +  +  +        +  +  +  +  +  +  +  +  +   |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                             X            |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +     +  +  +        +  +  +  +  +  +  +  +  +   |             
      Carcinoma, Metastatic, Kidney        |                                                             X            |             
      Leukemia Mononuclear                 |                                     X                                    |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +     +  +  +        +  +  +  +  +  +  +  +  +   |             
      Leukemia Mononuclear                 |                                     X                                    |             
      Pheochromocytoma Benign              |       X                                                                  |             
      Bilateral, Pheochromocytoma Benign   |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +  +  +  +  +  +   |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           | X                                                                        |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +     +  +  M        +  M  +  M  +  +  +  M  M   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  M  +  +     M  +  +        +  +  +  +  +  +  +  +  +   |             
      Pars Distalis, Adenoma               | X                                            X  X           X            |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +     +  +  +        +  +  +  +  +  +  +  +  +   |             
      C-Cell, Adenoma, Multiple            |                                                                          |             
      Follicular Cell, Adenoma             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Adenoma                              |                X                                                  X      |             
      Lymphoma Malignant Histiocytic       |                                  X                                       |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  M  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  M  +     +  +  +     +  +  +  +  +  +  +  +  +  +   |             
      Leukemia Mononuclear                 |                                     X                                    |             
      Polyp Stromal                        |                               X                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +     +  +  +        +  +  +  +  +  +  +  +  +   |             
      Leukemia Mononuclear                 |                                     X                                    |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +        M                       +     +     +     +                  |             
      Axillary, Leukemia Mononuclear       |                                     X                                    |             
      Mediastinal, Hepatocellular          |                                                                          |             
          Carcinoma, Metastatic, Liver     |                                                                          |             
      Mediastinal, Leukemia Mononuclear    |                                     X                                    |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  31                                                               
NTP Experiment-Test: 05061-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 17:56:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 5| 2| 7| 7| 7| 6| 4| 7| 6| 6| 4| 4| 7| 7| 6| 5| 4| 7| 6| 6| 5| 4|             
                             DAY ON TEST   | 2| 2| 9| 6| 7| 2| 2| 0| 1| 6| 2| 8| 6| 6| 6| 2| 2| 7| 6| 1| 0| 3| 1| 8| 6|             
                                           | 9| 9| 5| 6| 9| 9| 9| 2| 6| 4| 0| 5| 2| 2| 2| 9| 2| 4| 9| 8| 2| 8| 0| 0| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    1.0%                                   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    71MHF                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Pancreatic, Leukemia Mononuclear     |                                     X                                    |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  M  +  +  +  +     +  +  +        +  M  M  +  +  +  +  +  +   |             
      Leukemia Mononuclear                 |                                     X                                    |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  M  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Leukemia Mononuclear                 |                                     X                                    |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +     +  +  +        +  +  +  +  +  +  +  +  +   |             
      Leukemia Mononuclear                 |                                     X                                    |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  M  +  +  M  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                          |             
      Leukemia Mononuclear                 |                                     X                                    |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  M  M  +  +  +  M  +  +     +  +  +        +  +  +  +  +  +  +  +  +   |             
      Fibroadenoma                         |                X                    X                          X  X      |             
      Leukemia Mononuclear                 |                                     X                                    |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +     +  +  +        +  +  +  +  +  +  +  +  +   |             
      Squamous Cell Papilloma              |                                                                          |             
      Pinna, Squamous Cell Papilloma       |                                                                          |             
      Subcutaneous Tissue, Fibroma         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +     +  +  +        +  +  +  +  +  +  +  +  +   |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Uncertain Primary Site          |                                     X                                    |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +     +  +  +        +  +  +  +  +  +  +  +  +   |             
      Oligodendroglioma Benign             |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Carcinoma       |                                                             X            |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           | X     X        X  X  X  X     X  X                          X     X      |             
      Leukemia Mononuclear                 |                                     X                                    |             
      Neoplasm NOS, Metastatic, Uncertain  |                                                                          |             
          Primary Site                     |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +     +  +  +        +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +     +  +  +        +  +  +  +  +  +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     | +                                                                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  32                                                               
NTP Experiment-Test: 05061-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 17:56:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 5| 2| 7| 7| 7| 6| 4| 7| 6| 6| 4| 4| 7| 7| 6| 5| 4| 7| 6| 6| 5| 4|             
                             DAY ON TEST   | 2| 2| 9| 6| 7| 2| 2| 0| 1| 6| 2| 8| 6| 6| 6| 2| 2| 7| 6| 1| 0| 3| 1| 8| 6|             
                                           | 9| 9| 5| 6| 9| 9| 9| 2| 6| 4| 0| 5| 2| 2| 2| 9| 2| 4| 9| 8| 2| 8| 0| 0| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    1.0%                                   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    71MHF                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                +     +        +                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                     X                                    |             
      Pelvis, Transitional Epithelium,     |                                                                          |             
           Papilloma                       |                                                                          |             
      Renal Tubule, Adenoma                | X                    X              X                       X            |             
      Renal Tubule, Adenoma, Multiple      |                   X                             X                        |             
      Renal Tubule, Carcinoma              |                                                             X            |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma                            |                                        X                                 |             
      Papilloma                            |                                                                          |             
      Squamous Cell Carcinoma              |                            X                                            X|             
      Transitional Epithelium, Carcinoma   |                         X                    X              X  X  X  X   |             
      Transitional Epithelium, Papilloma   |    X  X                          X  X           X                        |             
      Transitional Epithelium, Squamous    |                                                                          |             
          Cell Papilloma                   |                                                                          |             
      Transitional Epithelium, Squamous    |                                                                          |             
          Cell Papilloma, Multiple         |                X                                                         |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                     X                                    |             
      Lymphoma Malignant Histiocytic       |                                  X                                       |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  33                                                               
NTP Experiment-Test: 05061-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 17:56:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 5| 2| 7| 7| 6| 6| 2| 7| 7| 5| 4| 0| 6| 4| 4| 2| 2| 7| 7| 7| 6| 5|             
                             DAY ON TEST   | 3| 3| 2| 4| 8| 2| 2| 3| 1| 8| 2| 1| 9| 6| 4| 5| 6| 6| 7| 7| 2| 1| 0| 0| 5|             
                                           | 6| 6| 5| 3| 1| 9| 9| 5| 4| 1| 9| 4| 8| 4| 2| 8| 2| 2| 9| 9| 9| 5| 5| 0| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    1.0%                                   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    71MHF                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  M  +  +  +  +  +  +  +        +        +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  M  +  +  +  +  +        +        +  +  +  +  +  +  +|             
      Adenocarcinoma                       |                                                                          |             
      Polyp Adenomatous                    |                                                                          |             
      Polyp Adenomatous, Multiple          |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  M  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma                       |                X                                               X         |             
      Adenocarcinoma, Multiple             |       X                                                                  |             
      Polyp Adenomatous                    |    X  X  X                                         X        X        X  X|             
      Polyp Adenomatous, Multiple          | X              X  X     X     X  X           X                 X  X      |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  M  +  +  +  +  +        +        +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  M  +  +  +  M  +  +  +  +  +        +        +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  M  +  +  +  +  +        +        +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  M  M  +  +  +  +        +        +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  M  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Cholangioma                          |                                                                          |             
      Hepatocellular Carcinoma             |    X           X                                                         |             
      Hepatocellular Carcinoma, Multiple   | X     X  X        X     X     X  X  X        X  X  X        X  X  X  X   |             
      Hepatocellular Adenoma               |                         X                                                |             
      Hepatocellular Adenoma, Multiple     | X  X     X     X              X        X     X  X  X                    X|             
      Hepatocholangiocarcinoma             |                         X                                            X   |             
      Hepatocholangiocarcinoma, Multiple   |                X  X                          X                           |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |             M              M        +                 M  M        +      |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                   X      |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  M  +  +  +  +  +        +        +  +  +  +  M  +  +|             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +        +        +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  M  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Squamous Cell Carcinoma              |                                                                      X   |             
      Squamous Cell Papilloma              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  M  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                  X                                       |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                         +|             
      Squamous Cell Papilloma              |                                                                         X|             
                                            __________________________________________________________________________|             
   Tooth                                   |                   +                                                      |             
      Gingiva, Squamous Cell Carcinoma     |                   X                                                      |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  34                                                               
NTP Experiment-Test: 05061-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 17:56:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 5| 2| 7| 7| 6| 6| 2| 7| 7| 5| 4| 0| 6| 4| 4| 2| 2| 7| 7| 7| 6| 5|             
                             DAY ON TEST   | 3| 3| 2| 4| 8| 2| 2| 3| 1| 8| 2| 1| 9| 6| 4| 5| 6| 6| 7| 7| 2| 1| 0| 0| 5|             
                                           | 6| 6| 5| 3| 1| 9| 9| 5| 4| 1| 9| 4| 8| 4| 2| 8| 2| 2| 9| 9| 9| 5| 5| 0| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    1.0%                                   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    71MHF                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +        +        +  +  +  +  +  +  +|             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                   X      |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  M  +  +  +  +  +        +        +  +  M  +  +  +  +|             
      Carcinoma, Metastatic, Kidney        |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  M  +  +  +  +  +        +        +  +  M  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Pheochromocytoma Benign              |                                                                          |             
      Bilateral, Pheochromocytoma Benign   |    X                                                                     |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +     +  +  M  +     +  +  +        +              +  +  M  +  +|             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  M  +  +  M  +  +        +        +  +  M  +  +  +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +        +        +  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               |       X  X                    X     X        X                    X      |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +        +        +  +  +  +  +  +  +|             
      C-Cell, Adenoma, Multiple            |                                                                          |             
      Follicular Cell, Adenoma             |                X                                                         |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  M  +  +  +  +  +        +        +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  M  +  +  +  +  +        +     +  +  +  +  +  +  +  +|             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                X         |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  M  +  +  +  +  +        +        +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Polyp Stromal                        | X                                                                       X|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +        +        +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |       +     +              M  +                 +  +  +  +  +     +  +   |             
      Axillary, Leukemia Mononuclear       |                                                                          |             
      Mediastinal, Hepatocellular          |                                                                          |             
          Carcinoma, Metastatic, Liver     |                                                                   X      |             
      Mediastinal, Leukemia Mononuclear    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  35                                                               
NTP Experiment-Test: 05061-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 17:56:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 5| 2| 7| 7| 6| 6| 2| 7| 7| 5| 4| 0| 6| 4| 4| 2| 2| 7| 7| 7| 6| 5|             
                             DAY ON TEST   | 3| 3| 2| 4| 8| 2| 2| 3| 1| 8| 2| 1| 9| 6| 4| 5| 6| 6| 7| 7| 2| 1| 0| 0| 5|             
                                           | 6| 6| 5| 3| 1| 9| 9| 5| 4| 1| 9| 4| 8| 4| 2| 8| 2| 2| 9| 9| 9| 5| 5| 0| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    1.0%                                   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    71MHF                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Pancreatic, Leukemia Mononuclear     |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  M  +  +  +  +  M  +  +  +  +  +        +        M  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  M  +  +  +  +  +  +     +        +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  M  +  +  +  +  +        +        +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  M  +  +  +  M  +  +     +  +  +  +  +  +  +  +  M  M|             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                   X      |             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  M  +  M  +  +  M  +  +  M  +  +        +        M  M  +  +  M  +  +|             
      Fibroadenoma                         |                                                                X         |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +        +  +  +  +  +  +  +|             
      Squamous Cell Papilloma              |                                                                          |             
      Pinna, Squamous Cell Papilloma       |                X                                                         |             
      Subcutaneous Tissue, Fibroma         |                                        X                                 |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +        +        +  +  +  +  +  +  +|             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Uncertain Primary Site          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +        +        +  +  +  +  +  +  +|             
      Oligodendroglioma Benign             |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +        +     +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Carcinoma       |                                                                          |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                X  X     X        X  X                       X  X  X      |             
      Leukemia Mononuclear                 |                                                                          |             
      Neoplasm NOS, Metastatic, Uncertain  |                                                                          |             
          Primary Site                     |                      X                                                   |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +        +        +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +        +        +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                +                                                         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  36                                                               
NTP Experiment-Test: 05061-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 17:56:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 5| 2| 7| 7| 6| 6| 2| 7| 7| 5| 4| 0| 6| 4| 4| 2| 2| 7| 7| 7| 6| 5|             
                             DAY ON TEST   | 3| 3| 2| 4| 8| 2| 2| 3| 1| 8| 2| 1| 9| 6| 4| 5| 6| 6| 7| 7| 2| 1| 0| 0| 5|             
                                           | 6| 6| 5| 3| 1| 9| 9| 5| 4| 1| 9| 4| 8| 4| 2| 8| 2| 2| 9| 9| 9| 5| 5| 0| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    1.0%                                   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    71MHF                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |       +           +                                               +      |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  M  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Pelvis, Transitional Epithelium,     |                                                                          |             
           Papilloma                       |                               X                                          |             
      Renal Tubule, Adenoma                | X  X  X                          X                                X      |             
      Renal Tubule, Adenoma, Multiple      |                X                                               X         |             
      Renal Tubule, Carcinoma              |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  M  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Carcinoma                            |                                        X                                 |             
      Papilloma                            |                                        X                                 |             
      Squamous Cell Carcinoma              |                                                                          |             
      Transitional Epithelium, Carcinoma   | X     X        X  X     X        X  X                       X            |             
      Transitional Epithelium, Papilloma   |                                                                   X      |             
      Transitional Epithelium, Squamous    |                                                                          |             
          Cell Papilloma                   |                                                                          |             
      Transitional Epithelium, Squamous    |                                                                          |             
          Cell Papilloma, Multiple         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  37                                                               
NTP Experiment-Test: 05061-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 17:56:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 4| 2| 2| 7| 7| 6| 5| 5| 7| 6| 6| 4| 2| 4| 4| 3| 2| 2|              |            |
                             DAY ON TEST   | 1| 3| 6| 7| 7| 2| 2| 7| 7| 1| 2| 6| 6| 6| 7| 6| 6| 6| 8| 7|              |            |
                                           | 9| 7| 0| 9| 9| 9| 9| 3| 6| 2| 9| 4| 2| 2| 9| 4| 4| 7| 1| 9|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |     A      |
    1.0%                                   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|              |     L      |
    71MHF                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +     +        +  +  +               |  58        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | M  +  +  +  +  +  +  +  +  +  +  +  +     +        +  +  +               |  57        |
      Adenocarcinoma                       |                                                                          |          1 |
      Polyp Adenomatous                    |                X                                                         |          1 |
      Polyp Adenomatous, Multiple          |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  67        |
      Adenocarcinoma                       |                      X        X                                          |          6 |
      Adenocarcinoma, Multiple             |                                                                          |          1 |
      Polyp Adenomatous                    |    X                       X           X                                 |         14 |
      Polyp Adenomatous, Multiple          | X              X  X  X  X     X  X  X                                    |         31 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +     +        +  +  +               |  57        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  A     +        +  +  +               |  56        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  A     +        +  +  +               |  56        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  A     +        +  +  +               |  54        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  68        |
      Cholangioma                          | X                                                                        |          1 |
      Hepatocellular Carcinoma             |       X                    X           X     X                           |          7 |
      Hepatocellular Carcinoma, Multiple   | X  X           X  X  X  X     X  X  X           X                        |         44 |
      Hepatocellular Adenoma               |                                     X  X        X                        |         10 |
      Hepatocellular Adenoma, Multiple     |    X           X  X     X  X  X  X           X                           |         27 |
      Hepatocholangiocarcinoma             |                                                                          |          8 |
      Hepatocholangiocarcinoma, Multiple   |                      X                                                   |          5 |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |          M  M                             M  +        M  M               |   5        |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +     +        +  +  +               |  58        |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pharynx                                 |                                                 +                        |   1        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  M  +  +  +     +        +  +  +               |  58        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  67        |
      Squamous Cell Carcinoma              |                                                                          |          1 |
      Squamous Cell Papilloma              |                X                                                         |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  68        |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  38                                                               
NTP Experiment-Test: 05061-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 17:56:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 4| 2| 2| 7| 7| 6| 5| 5| 7| 6| 6| 4| 2| 4| 4| 3| 2| 2|              |            |
                             DAY ON TEST   | 1| 3| 6| 7| 7| 2| 2| 7| 7| 1| 2| 6| 6| 6| 7| 6| 6| 6| 8| 7|              |            |
                                           | 9| 7| 0| 9| 9| 9| 9| 3| 6| 2| 9| 4| 2| 2| 9| 4| 4| 7| 1| 9|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |     A      |
    1.0%                                   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|              |     L      |
    71MHF                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Squamous Cell Papilloma              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
      Gingiva, Squamous Cell Carcinoma     |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +     +        +  +  +               |  59        |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +  +               |  58        |
      Carcinoma, Metastatic, Kidney        |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +  +               |  58        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Pheochromocytoma Benign              |                                              X                           |          2 |
      Bilateral, Pheochromocytoma Benign   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +        +  +  +  +  +  +  +  +              +                     |  47        |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  M  +  +  +  +  M  +  +  +  +  +     +        +  +  +               |  48        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +     +        +  +  +               |  57        |
      Pars Distalis, Adenoma               |                   X        X        X                                    |         13 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +     +        +  +  +               |  59        |
      C-Cell, Adenoma, Multiple            | X                                                                        |          1 |
      Follicular Cell, Adenoma             |                                  X                                       |          2 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |             +                                                            |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  M  M  +  +  +  +  +  +  +  +  +  +     +        +  +  +               |  58        |
      Adenoma                              |                                                                          |          2 |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +  +  +               |  61        |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +               |  60        |
      Leukemia Mononuclear                 |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  39                                                               
NTP Experiment-Test: 05061-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 17:56:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 4| 2| 2| 7| 7| 6| 5| 5| 7| 6| 6| 4| 2| 4| 4| 3| 2| 2|              |            |
                             DAY ON TEST   | 1| 3| 6| 7| 7| 2| 2| 7| 7| 1| 2| 6| 6| 6| 7| 6| 6| 6| 8| 7|              |            |
                                           | 9| 7| 0| 9| 9| 9| 9| 3| 6| 2| 9| 4| 2| 2| 9| 4| 4| 7| 1| 9|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |     A      |
    1.0%                                   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|              |     L      |
    71MHF                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Polyp Stromal                        |                            X     X           X                           |          6 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +     +        +  +  +               |  59        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +     +  +     +     +                 M           +  +               |  24        |
      Axillary, Leukemia Mononuclear       |                                                                          |          1 |
      Mediastinal, Hepatocellular          |                                                                          |            |
          Carcinoma, Metastatic, Liver     |                                                                          |          1 |
      Mediastinal, Leukemia Mononuclear    |                                                                          |          1 |
      Pancreatic, Leukemia Mononuclear     |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +     +        +  +  +               |  53        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | M  +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +  +               |  60        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +     +        +  +  +               |  58        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  M  +  M  M  +  +  +  +  M  M  +  +  +  +  M  +  +  +  +               |  55        |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  M  +  +  +  +  +  M  +  +     +        +  +  +               |  47        |
      Fibroadenoma                         |                                                                          |          5 |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +     +        +  +  +               |  60        |
      Squamous Cell Papilloma              |    X                                                                     |          1 |
      Pinna, Squamous Cell Papilloma       |                   X                                                      |          2 |
      Subcutaneous Tissue, Fibroma         |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +     +        +  +  +               |  59        |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Uncertain Primary Site          |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +     +        +  +  +               |  59        |
      Oligodendroglioma Benign             |    X                                                                     |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  40                                                               
NTP Experiment-Test: 05061-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 17:56:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 4| 2| 2| 7| 7| 6| 5| 5| 7| 6| 6| 4| 2| 4| 4| 3| 2| 2|              |            |
                             DAY ON TEST   | 1| 3| 6| 7| 7| 2| 2| 7| 7| 1| 2| 6| 6| 6| 7| 6| 6| 6| 8| 7|              |            |
                                           | 9| 7| 0| 9| 9| 9| 9| 3| 6| 2| 9| 4| 2| 2| 9| 4| 4| 7| 1| 9|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |     A      |
    1.0%                                   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|              |     L      |
    71MHF                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                         +                                                |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +  +  +               |  64        |
      Alveolar/Bronchiolar Carcinoma       |                                                                          |          1 |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |    X           X  X     X     X  X                                       |         24 |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Neoplasm NOS, Metastatic, Uncertain  |                                                                          |            |
          Primary Site                     |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +     +        +  +  +               |  59        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +     +        +  +  +               |  59        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                   +                                                      |   3        |
                                            __________________________________________________________________________|____________|
   Eye                                     | +                                                                        |   7        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  68        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Pelvis, Transitional Epithelium,     |                                                                          |            |
           Papilloma                       |                                                                          |          1 |
      Renal Tubule, Adenoma                |                   X           X                                          |         11 |
      Renal Tubule, Adenoma, Multiple      |                X                                                         |          5 |
      Renal Tubule, Carcinoma              |                   X                                                      |          2 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +               |  66        |
      Carcinoma                            |                                                                          |          2 |
      Papilloma                            |                                                                          |          1 |
      Squamous Cell Carcinoma              |                                                                          |          2 |
      Transitional Epithelium, Carcinoma   |                      X                             X                     |         16 |
      Transitional Epithelium, Papilloma   | X  X                             X                                       |          9 |
      Transitional Epithelium, Squamous    |                                                                          |            |
          Cell Papilloma                   |                      X                                                   |          1 |
      Transitional Epithelium, Squamous    |                                                                          |            |
          Cell Papilloma, Multiple         |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  69        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  41                                                               
NTP Experiment-Test: 05061-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 17:56:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 2| 2| 4| 4| 0| 4| 3| 4| 4| 2| 2| 2| 4| 3| 2| 2| 2| 4| 4| 4| 4| 2|             
                             DAY ON TEST   | 6| 6| 2| 8| 7| 6| 6| 6| 6| 0| 6| 6| 9| 9| 7| 4| 1| 7| 7| 7| 6| 6| 6| 2| 7|             
                                           | 4| 2| 6| 1| 9| 4| 2| 5| 2| 6| 4| 4| 9| 4| 9| 1| 3| 9| 9| 9| 4| 4| 2| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    2.0%                                   | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    71HF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +     +  +  +  M  +  +  +  +     +  +  +  +  +  +  +  +|             
      Polyp Adenomatous                    |       X                    X                                             |             
      Polyp Adenomatous, Multiple          |                         X                                                |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +     +  A  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Hepatocellular Carcinoma             |    X              X     X                                   X  X  X      |             
      Hepatocellular Carcinoma, Multiple   | X     X        X              X  X           X                       X   |             
      Hepatocellular Adenoma               |                   X     X                          X        X            |             
      Hepatocellular Adenoma, Multiple     | X  X           X           X  X  X                             X         |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                  +                                       |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |       +                    +        +  +     +                       +   |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +     +  +  +  +  +  M  +  M     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  M  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Polyp Stromal                        |                X                                                         |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |       +  M  M                    +  +     +        +  M  M              +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  42                                                               
NTP Experiment-Test: 05061-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 17:56:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 2| 2| 4| 4| 0| 4| 3| 4| 4| 2| 2| 2| 4| 3| 2| 2| 2| 4| 4| 4| 4| 2|             
                             DAY ON TEST   | 6| 6| 2| 8| 7| 6| 6| 6| 6| 0| 6| 6| 9| 9| 7| 4| 1| 7| 7| 7| 6| 6| 6| 2| 7|             
                                           | 4| 2| 6| 1| 9| 4| 2| 5| 2| 6| 4| 4| 9| 4| 9| 1| 3| 9| 9| 9| 4| 4| 2| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    2.0%                                   | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    71HF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  M     +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  M  +  M     +  +  +  +  +  +  +  M     +  +  +  +  +  I  M  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  M  M  +  +     M  +  M  +  +  +  +  +     +  M  +  +  +  M  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                              X                           |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |          M  M                       +     M        M  M  M              +|             
                                            __________________________________________________________________________|             
   Harderian Gland                         |          M  M                             M        M  M  M              +|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                    X                     |             
      Renal Tubule, Adenoma                |                                                                X         |             
      Renal Tubule, Adenoma, Multiple      |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Carcinoma                            |                   X     X        X                             X         |             
      Papilloma                            |                               X                                          |             
      Transitional Epithelium, Carcinoma   |                                     X                                    |             
      Transitional Epithelium, Papilloma   |       X                                                                  |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  43                                                               
NTP Experiment-Test: 05061-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 17:56:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 2| 2| 2|                                                           |            |
                             DAY ON TEST   | 6| 6| 8| 7| 7|                                                           |            |
                                           | 2| 1| 1| 9| 9|                                                           |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0|                                                           |     O      |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1|                                                           |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2|                                                           |     A      |
    2.0%                                   | 4| 4| 4| 4| 4|                                                           |     L      |
    71HF                                   | 1| 2| 3| 4| 5|                                                           |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +                                                            |  28        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +                                                            |  28        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +                                                            |  27        |
      Polyp Adenomatous                    |                                                                          |          2 |
      Polyp Adenomatous, Multiple          |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +                                                            |  28        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +                                                            |  28        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +                                                            |  27        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +                                                            |  28        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +                                                            |  28        |
      Hepatocellular Carcinoma             | X           X                                                            |          8 |
      Hepatocellular Carcinoma, Multiple   |    X                                                                     |          8 |
      Hepatocellular Adenoma               |          X                                                               |          5 |
      Hepatocellular Adenoma, Multiple     |                                                                          |          7 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +                                                            |  28        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +                                                            |  28        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +                                                            |  28        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +                                                            |  28        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +                                                            |  28        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  M  +  +  +                                                            |  27        |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  M  +  +  +                                                            |  27        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |    +                                                                     |   7        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  M  +  +  +                                                            |  25        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +                                                            |  28        |
      Pars Distalis, Adenoma               |    X  X                                                                  |          2 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +                                                            |  28        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +                                                            |  27        |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +                                                            |  28        |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +                                                            |  28        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  44                                                               
NTP Experiment-Test: 05061-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 17:56:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 2| 2| 2|                                                           |            |
                             DAY ON TEST   | 6| 6| 8| 7| 7|                                                           |            |
                                           | 2| 1| 1| 9| 9|                                                           |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0|                                                           |     O      |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1|                                                           |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2|                                                           |     A      |
    2.0%                                   | 4| 4| 4| 4| 4|                                                           |     L      |
    71HF                                   | 1| 2| 3| 4| 5|                                                           |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Polyp Stromal                        |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +                                                            |  28        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +     M  +  +                                                            |   9        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +                                                            |  27        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +                                                            |  28        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +                                                            |  28        |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  M  +  +  +                                                            |  22        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  +  +  M  M                                                            |  19        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +                                                            |  28        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +                                                            |  28        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +                                                            |  28        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +                                                            |  28        |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +                                                            |  28        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +                                                            |  28        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |       M  M  M                                                            |   2        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |       M  M  M                                                            |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +                                                            |  28        |
      Adenoma                              |                                                                          |          1 |
      Renal Tubule, Adenoma                |                                                                          |          1 |
      Renal Tubule, Adenoma, Multiple      | X                                                                        |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +                                                            |  28        |
      Carcinoma                            |                                                                          |          4 |
      Papilloma                            |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  45                                                               
NTP Experiment-Test: 05061-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 17:56:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 2| 2| 2|                                                           |            |
                             DAY ON TEST   | 6| 6| 8| 7| 7|                                                           |            |
                                           | 2| 1| 1| 9| 9|                                                           |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0|                                                           |     O      |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1|                                                           |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2|                                                           |     A      |
    2.0%                                   | 4| 4| 4| 4| 4|                                                           |     L      |
    71HF                                   | 1| 2| 3| 4| 5|                                                           |            |
 __________________________________________________________________________________________________________________________________ 
      Transitional Epithelium, Papilloma   |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +                                                            |  28        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  46                                                               
NTP Experiment-Test: 05061-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 17:56:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 5|                                            |            |
                                           | 4| 4| 4| 4| 2| 4| 4| 2| 2| 6|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |     A      |
    2.0%                                   | 1| 1| 1| 1| 1| 5| 5| 5| 5| 5|                                            |     L      |
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Polyp Adenomatous                    |          X     X  X  X  X                                                |          5 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Hepatocellular Carcinoma             |             X     X     X                                                |          3 |
      Hepatocellular Carcinoma, Multiple   | X  X                 X                                                   |          3 |
      Hepatocellular Adenoma               | X           X  X     X     X                                             |          5 |
      Hepatocellular Adenoma, Multiple     |                   X                                                      |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                +                                                         |   1        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |                            +                                             |   1        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Pars Distalis, Adenoma               |    X                       X                                             |          2 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Adenoma                              |          X                                                               |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  47                                                               
NTP Experiment-Test: 05061-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 17:56:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 5|                                            |            |
                                           | 4| 4| 4| 4| 2| 4| 4| 2| 2| 6|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |     A      |
    2.0%                                   | 1| 1| 1| 1| 1| 5| 5| 5| 5| 5|                                            |     L      |
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Polyp Stromal                        |          X                                                               |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +                                                                        |   1        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  M  +  +  +  +  +                                             |   9        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | M  +  +  +  +  +  +  +  +  +                                             |   9        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  M  +  +  +  M  +  M  +                                             |   7        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |             X                                                            |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Renal Tubule, Adenoma                |    X              X     X                                                |          3 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Carcinoma                            |                      X                                                   |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  48                                                               
NTP Experiment-Test: 05061-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 17:56:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 4| 6| 5| 7| 7| 7| 2| 2| 6| 6| 5| 2| 2| 4| 7| 2| 2| 2| 7| 7| 7| 6| 2|             
                             DAY ON TEST   | 3| 9| 5| 7| 8| 3| 3| 0| 7| 7| 6| 4| 5| 7| 7| 5| 3| 7| 7| 7| 3| 3| 2| 5| 7|             
                                           | 5| 2| 6| 4| 7| 4| 4| 7| 5| 5| 6| 6| 6| 6| 6| 8| 4| 3| 6| 5| 4| 4| 7| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    UNTREATE                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    D 71 UM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                      X   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                               X                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Carcinoma             |                               X                                          |             
      Hepatocellular Adenoma               |                                                                          |             
      Leukemia Mononuclear                 |    X     X  X     X           X  X              X                 X  X   |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                X         |             
      Leukemia Mononuclear                 |          X                    X                                      X   |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parotid Gland, Leukemia Mononuclear  |                                                                          |             
      Submandibular Gland, Leukemia        |                                                                          |             
          Mononuclear                      |                                                                      X   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Leukemia Mononuclear                 |          X                                                               |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X                                                           X   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X                    X  X                                X  X   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X     X                    X  X                                X  X   |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X     X                    X  X                                   X   |             
      Pheochromocytoma Malignant           |    X                                                                     |             
      Pheochromocytoma Benign              |                X                 X                          X            |             
      Bilateral, Pheochromocytoma Benign   |                   X                                                      |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +        +  +  +        +  +           +  +  +  +   |             
      Adenoma                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  49                                                               
NTP Experiment-Test: 05061-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 17:56:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 4| 6| 5| 7| 7| 7| 2| 2| 6| 6| 5| 2| 2| 4| 7| 2| 2| 2| 7| 7| 7| 6| 2|             
                             DAY ON TEST   | 3| 9| 5| 7| 8| 3| 3| 0| 7| 7| 6| 4| 5| 7| 7| 5| 3| 7| 7| 7| 3| 3| 2| 5| 7|             
                                           | 5| 2| 6| 4| 7| 4| 4| 7| 5| 5| 6| 6| 6| 6| 6| 8| 4| 3| 6| 5| 4| 4| 7| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    UNTREATE                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    D 71 UM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               | X  X     X  X     X  X           X  X                          X  X      |             
      Pars Distalis, Adenoma, Multiple     |                                                                          |             
      Pars Distalis, Leukemia Mononuclear  |          X                    X  X                                   X   |             
      Pars Intermedia, Leukemia Mononuclear|          X                                                           X   |             
      Pars Nervosa, Leukemia Mononuclear   |          X                                                           X   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Leukemia Mononuclear                 |          X                                                               |             
      C-Cell, Adenoma                      | X     X  X                                                        X      |             
      Follicular Cell, Carcinoma           | X                                                                        |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X                                                           X   |             
      Mesothelioma Malignant               |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Adenocarcinoma                       |                                                                          |             
      Adenoma                              |                                                                X         |             
      Leukemia Mononuclear                 |          X                    X                                      X   |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X                                                           X   |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X                                                               |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Leukemia Mononuclear                 |          X                       X                                       |             
      Mesothelioma Malignant               |                                                                          |             
      Bilateral, Interstitial Cell, Adenoma| X  X     X     X  X  X        X  X  X           X           X  X  X  X   |             
      Interstitial Cell, Adenoma           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X  X                 X                                   X  X   |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +  M  +  +           M  M  +        M  M  M  +  M  +  M           +  M|             
      Lumbar, Leukemia Mononuclear         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  50                                                               
NTP Experiment-Test: 05061-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 17:56:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 4| 6| 5| 7| 7| 7| 2| 2| 6| 6| 5| 2| 2| 4| 7| 2| 2| 2| 7| 7| 7| 6| 2|             
                             DAY ON TEST   | 3| 9| 5| 7| 8| 3| 3| 0| 7| 7| 6| 4| 5| 7| 7| 5| 3| 7| 7| 7| 3| 3| 2| 5| 7|             
                                           | 5| 2| 6| 4| 7| 4| 4| 7| 5| 5| 6| 6| 6| 6| 6| 8| 4| 3| 6| 5| 4| 4| 7| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    UNTREATE                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    D 71 UM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Mediastinal, Leukemia Mononuclear    |    X     X                    X                                      X   |             
      Pancreatic, Leukemia Mononuclear     |                               X                                          |             
      Renal, Leukemia Mononuclear          |             X                 X                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X                    X  X                                X  X   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X        X           X  X                                   X   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X     X  X     X           X  X              X                 X  X   |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  M  +  +  +  +  M  +  +  +  +  M  M  M  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X                    X                                      X   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  +  +  M  M  +  +  M  +  +  +  +  +  +  +  M  M  +  +  +  M  +  M  M  M|             
      Fibroadenoma, Multiple               |    X                                                                     |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basal Cell Carcinoma                 |                   X                                                      |             
      Keratoacanthoma                      |    X                                                                     |             
      Leukemia Mononuclear                 |          X                    X                                          |             
      Squamous Cell Papilloma              |                                                                          |             
      Trichoepithelioma                    |                                                                          |             
      Subcutaneous Tissue, Fibroma         |                                  X                                       |             
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |             
      Subcutaneous Tissue, Leukemia        |                                                                          |             
          Mononuclear                      |                                                                      X   |             
      Subcutaneous Tissue, Lipoma          |                      X                                                   |             
      Subcutaneous Tissue, Sarcoma         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Abdominal, Mesothelioma Malignant    |                                                                          |             
      Intercostal, Leukemia Mononuclear    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X                    X                                   X  X   |             
      Oligodendroglioma Benign             |                                                                          |             
      Cerebrum, Meningioma Benign          |                                                          X               |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |          +  +                                                     +      |             
      Leukemia Mononuclear                 |          X                                                               |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  51                                                               
NTP Experiment-Test: 05061-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 17:56:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 4| 6| 5| 7| 7| 7| 2| 2| 6| 6| 5| 2| 2| 4| 7| 2| 2| 2| 7| 7| 7| 6| 2|             
                             DAY ON TEST   | 3| 9| 5| 7| 8| 3| 3| 0| 7| 7| 6| 4| 5| 7| 7| 5| 3| 7| 7| 7| 3| 3| 2| 5| 7|             
                                           | 5| 2| 6| 4| 7| 4| 4| 7| 5| 5| 6| 6| 6| 6| 6| 8| 4| 3| 6| 5| 4| 4| 7| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    UNTREATE                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    D 71 UM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Alveolar/Bronchiolar Adenoma         |                                                                          |             
      Leukemia Mononuclear                 |    X     X                    X  X              X                 X  X   |             
      Pheochromocytoma Malignant,          |                                                                          |             
          Metastatic, Adrenal Medulla      |    X                                                                     |             
      Sarcoma, Metastatic, Skin            |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X                    X  X                                   X   |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                         M  M  +        M  M        M  M  M              M|             
      Fibrosarcoma                         |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |             +                                                            |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
      Carcinoma                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X                    X  X                                   X   |             
      Renal Tubule, Adenoma                |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X                    X  X                                       |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X     X  X     X           X  X              X                 X  X   |             
      Mesothelioma Malignant               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  52                                                               
NTP Experiment-Test: 05061-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 17:56:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 7| 6| 4| 7| 7| 7| 4| 7| 7| 6| 6| 5| 7| 4| 6| 4| 2| 7| 4| 7| 7| 6|             
                             DAY ON TEST   | 3| 5| 3| 3| 7| 5| 3| 3| 2| 3| 3| 3| 7| 3| 1| 3| 5| 9| 5| 7| 3| 5| 3| 3| 7|             
                                           | 4| 6| 4| 5| 1| 6| 4| 5| 1| 5| 4| 5| 9| 1| 4| 4| 8| 6| 6| 6| 4| 6| 4| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    UNTREATE                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    D 71 UM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                         X                                                |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  M  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                         X                                                |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                         X                                                |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                         X                                         X      |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Carcinoma             |                                                                          |             
      Hepatocellular Adenoma               |                                                                          |             
      Leukemia Mononuclear                 |             X           X           X  X  X        X        X     X     X|             
                                            __________________________________________________________________________|             
   Mesentery                               |             +                       +                                    |             
      Leukemia Mononuclear                 |             X                                                            |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                       X                  |             
      Leukemia Mononuclear                 |             X           X                                                |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parotid Gland, Leukemia Mononuclear  |                                                                          |             
      Submandibular Gland, Leukemia        |                                                                          |             
          Mononuclear                      |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                         X              X  X        X                     |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X           X           X     X                              |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Leukemia Mononuclear                 |             X           X           X     X                              |             
      Pheochromocytoma Malignant           |                                                                          |             
      Pheochromocytoma Benign              |             X                       X              X                 X   |             
      Bilateral, Pheochromocytoma Benign   |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +        +     +  +  +|             
      Adenoma                              | X                    X                                                   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  53                                                               
NTP Experiment-Test: 05061-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 17:56:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 7| 6| 4| 7| 7| 7| 4| 7| 7| 6| 6| 5| 7| 4| 6| 4| 2| 7| 4| 7| 7| 6|             
                             DAY ON TEST   | 3| 5| 3| 3| 7| 5| 3| 3| 2| 3| 3| 3| 7| 3| 1| 3| 5| 9| 5| 7| 3| 5| 3| 3| 7|             
                                           | 4| 6| 4| 5| 1| 6| 4| 5| 1| 5| 4| 5| 9| 1| 4| 4| 8| 6| 6| 6| 4| 6| 4| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    UNTREATE                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    D 71 UM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  M  +  +  M  +  +  M  +  +  +  +  +  M  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  M  +  I  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               | X     X  X  X        X        X                                         X|             
      Pars Distalis, Adenoma, Multiple     |                                     X                                    |             
      Pars Distalis, Leukemia Mononuclear  |                                           X                              |             
      Pars Intermedia, Leukemia Mononuclear|                                                                          |             
      Pars Nervosa, Leukemia Mononuclear   |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Adenoma                              |                X                                                         |             
      Leukemia Mononuclear                 |                                           X                              |             
      C-Cell, Adenoma                      |          X  X                             X                              |             
      Follicular Cell, Carcinoma           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       |                                                                         +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Mesothelioma Malignant               |                                                                      X   |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Adenocarcinoma                       |                                                    X                     |             
      Adenoma                              |                                                    X                     |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                         X                                                |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |    X                                                                     |             
      Leukemia Mononuclear                 |                                           X                              |             
      Mesothelioma Malignant               |                                                                      X   |             
      Bilateral, Interstitial Cell, Adenoma|       X  X  X     X  X  X     X  X     X     X     X        X     X  X   |             
      Interstitial Cell, Adenoma           |                                     X                 X                 X|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X           X           X  X  X                              |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    M        +           +           +  +                 +  +            |             
      Lumbar, Leukemia Mononuclear         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  54                                                               
NTP Experiment-Test: 05061-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 17:56:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 7| 6| 4| 7| 7| 7| 4| 7| 7| 6| 6| 5| 7| 4| 6| 4| 2| 7| 4| 7| 7| 6|             
                             DAY ON TEST   | 3| 5| 3| 3| 7| 5| 3| 3| 2| 3| 3| 3| 7| 3| 1| 3| 5| 9| 5| 7| 3| 5| 3| 3| 7|             
                                           | 4| 6| 4| 5| 1| 6| 4| 5| 1| 5| 4| 5| 9| 1| 4| 4| 8| 6| 6| 6| 4| 6| 4| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    UNTREATE                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    D 71 UM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Mediastinal, Leukemia Mononuclear    |             X           X           X  X                    X            |             
      Pancreatic, Leukemia Mononuclear     |                         X           X                                    |             
      Renal, Leukemia Mononuclear          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X           X           X  X  X        X        X     X      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X           X              X  X        X        X     X      |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X           X           X  X  X        X        X     X     X|             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  M  +  M  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                         X                                                |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  M  +  +  +  M  M  +  +  +  +  M  M  +  +  M  M  M  M  +  M|             
      Fibroadenoma, Multiple               |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basal Cell Carcinoma                 |                                                                          |             
      Keratoacanthoma                      |                                                                          |             
      Leukemia Mononuclear                 |                                           X        X                     |             
      Squamous Cell Papilloma              |                                                                          |             
      Trichoepithelioma                    |                      X                                                   |             
      Subcutaneous Tissue, Fibroma         | X                                                                        |             
      Subcutaneous Tissue, Fibrosarcoma    |                                        X                                 |             
      Subcutaneous Tissue, Leukemia        |                                                                          |             
          Mononuclear                      |                                                                          |             
      Subcutaneous Tissue, Lipoma          |                                                                          |             
      Subcutaneous Tissue, Sarcoma         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                      +   |             
      Abdominal, Mesothelioma Malignant    |                                                                      X   |             
      Intercostal, Leukemia Mononuclear    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                           X                              |             
      Oligodendroglioma Benign             |                                                                          |             
      Cerebrum, Meningioma Benign          |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                         +                                                |             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  55                                                               
NTP Experiment-Test: 05061-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 17:56:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 7| 6| 4| 7| 7| 7| 4| 7| 7| 6| 6| 5| 7| 4| 6| 4| 2| 7| 4| 7| 7| 6|             
                             DAY ON TEST   | 3| 5| 3| 3| 7| 5| 3| 3| 2| 3| 3| 3| 7| 3| 1| 3| 5| 9| 5| 7| 3| 5| 3| 3| 7|             
                                           | 4| 6| 4| 5| 1| 6| 4| 5| 1| 5| 4| 5| 9| 1| 4| 4| 8| 6| 6| 6| 4| 6| 4| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    UNTREATE                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    D 71 UM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Alveolar/Bronchiolar Adenoma         |                                                                X         |             
      Leukemia Mononuclear                 |             X           X           X  X  X        X        X     X      |             
      Pheochromocytoma Malignant,          |                                                                          |             
          Metastatic, Adrenal Medulla      |                                                                          |             
      Sarcoma, Metastatic, Skin            |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X           X                          X                     |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                     +              +     M               |             
      Fibrosarcoma                         |                                                    X                     |             
                                            __________________________________________________________________________|             
   Eye                                     | I                       +                 +                              |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                              +                           |             
      Carcinoma                            |                                              X                           |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X           X           X  X  X        X                     |             
      Renal Tubule, Adenoma                |                                  X                                       |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X           X           X  X  X        X        X     X     X|             
      Mesothelioma Malignant               |                                                                      X   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  56                                                               
NTP Experiment-Test: 05061-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 17:56:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 5| 4| 7| 4| 7| 5| 4| 7| 7| 4| 5| 2| 7| 7| 7| 7| 5|              |            |
                             DAY ON TEST   | 5| 3| 2| 4| 2| 3| 2| 3| 7| 5| 3| 3| 5| 7| 7| 3| 3| 3| 3| 6|              |            |
                                           | 8| 4| 1| 9| 1| 4| 7| 4| 4| 6| 1| 1| 6| 3| 5| 4| 1| 3| 5| 2|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |     A      |
    UNTREATE                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |     L      |
    D 71 UM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  69        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  67        |
      Leukemia Mononuclear                 |       X                                                                  |          2 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | M  +  M  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  65        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  68        |
      Leukemia Mononuclear                 |       X                                                                  |          3 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  68        |
      Leukemia Mononuclear                 |       X                                                                  |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  68        |
      Leukemia Mononuclear                 |       X                                X                                 |          3 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  68        |
      Leukemia Mononuclear                 |       X                                X                                 |          5 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Hepatocellular Carcinoma             |                                                                          |          1 |
      Hepatocellular Adenoma               |                                              X                           |          1 |
      Leukemia Mononuclear                 |       X              X        X  X     X        X     X                  |         25 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |       +                                                                  |   3        |
      Leukemia Mononuclear                 |       X                                                                  |          2 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Adenoma                              |                                                       X                  |          3 |
      Leukemia Mononuclear                 |       X              X                 X                                 |          8 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Parotid Gland, Leukemia Mononuclear  |       X                                                                  |          1 |
      Submandibular Gland, Leukemia        |                                                                          |            |
          Mononuclear                      |       X                                X                                 |          3 |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  69        |
      Leukemia Mononuclear                 |       X                                                                  |          2 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Leukemia Mononuclear                 |       X                                X                                 |          4 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Leukemia Mononuclear                 |       X                          X     X        X                        |         13 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Leukemia Mononuclear                 |                      X                 X        X                        |         13 |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  69        |
      Leukemia Mononuclear                 |                                        X        X                        |         11 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  57                                                               
NTP Experiment-Test: 05061-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 17:56:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 5| 4| 7| 4| 7| 5| 4| 7| 7| 4| 5| 2| 7| 7| 7| 7| 5|              |            |
                             DAY ON TEST   | 5| 3| 2| 4| 2| 3| 2| 3| 7| 5| 3| 3| 5| 7| 7| 3| 3| 3| 3| 6|              |            |
                                           | 8| 4| 1| 9| 1| 4| 7| 4| 4| 6| 1| 1| 6| 3| 5| 4| 1| 3| 5| 2|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |     A      |
    UNTREATE                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |     L      |
    D 71 UM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Pheochromocytoma Malignant           |                                                                          |          1 |
      Pheochromocytoma Benign              |                         X        X              X     X                  |         11 |
      Bilateral, Pheochromocytoma Benign   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |    +  +  +  +  +  +  +  +     +  +     +     +  +  +  +  +               |  54        |
      Adenoma                              |                                                                          |          2 |
      Leukemia Mononuclear                 |       X                                                                  |          1 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +               |  63        |
      Leukemia Mononuclear                 |       X                                                                  |          1 |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  65        |
      Pars Distalis, Adenoma               |          X     X           X     X                                       |         21 |
      Pars Distalis, Adenoma, Multiple     |                                                                          |          1 |
      Pars Distalis, Leukemia Mononuclear  |       X                          X     X        X                        |          9 |
      Pars Intermedia, Leukemia Mononuclear|                                                                          |          2 |
      Pars Nervosa, Leukemia Mononuclear   |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  69        |
      Adenoma                              |                                                                          |          1 |
      Leukemia Mononuclear                 |       X                                X                                 |          4 |
      C-Cell, Adenoma                      |    X              X                                   X                  |         10 |
      Follicular Cell, Carcinoma           |                               X                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Coagulating Gland                       |                                  +                                       |   2        |
      Leukemia Mononuclear                 |                                  X                                       |          1 |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Leukemia Mononuclear                 |       X                                                                  |          3 |
      Mesothelioma Malignant               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +               |  67        |
      Adenocarcinoma                       |                                                                          |          1 |
      Adenoma                              |    X                                                                     |          3 |
      Leukemia Mononuclear                 |       X                                                                  |          4 |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Leukemia Mononuclear                 |       X                                         X                        |          4 |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  69        |
      Leukemia Mononuclear                 |       X                                X        X                        |          5 |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Adenoma                              |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  58                                                               
NTP Experiment-Test: 05061-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 17:56:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 5| 4| 7| 4| 7| 5| 4| 7| 7| 4| 5| 2| 7| 7| 7| 7| 5|              |            |
                             DAY ON TEST   | 5| 3| 2| 4| 2| 3| 2| 3| 7| 5| 3| 3| 5| 7| 7| 3| 3| 3| 3| 6|              |            |
                                           | 8| 4| 1| 9| 1| 4| 7| 4| 4| 6| 1| 1| 6| 3| 5| 4| 1| 3| 5| 2|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |     A      |
    UNTREATE                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |     L      |
    D 71 UM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Leukemia Mononuclear                 |       X                                         X                        |          5 |
      Mesothelioma Malignant               |                                                                          |          1 |
      Bilateral, Interstitial Cell, Adenoma|    X  X     X        X        X  X     X     X  X  X  X  X               |         40 |
      Interstitial Cell, Adenoma           | X              X                                                         |          5 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Leukemia Mononuclear                 |       X                          X     X                                 |         13 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |    +  +              +           +     +  M     +                        |  19        |
      Lumbar, Leukemia Mononuclear         |       X                                                                  |          1 |
      Mediastinal, Leukemia Mononuclear    |                      X           X     X        X                        |         13 |
      Pancreatic, Leukemia Mononuclear     |                                        X                                 |          4 |
      Renal, Leukemia Mononuclear          |       X                                                                  |          3 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Leukemia Mononuclear                 |       X              X           X     X        X                        |         18 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  68        |
      Leukemia Mononuclear                 |       X                          X     X                                 |         15 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Leukemia Mononuclear                 |       X              X           X     X        X                        |         23 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  M  +  +  +  +  M  +  +  +  M  +  +  +  +  M  M  +  +               |  56        |
      Leukemia Mononuclear                 |                                        X                                 |          5 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  M  M  +  M  +  +  +  +  M  M  M  M  M  +  M  M  +  +  M               |  39        |
      Fibroadenoma, Multiple               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Basal Cell Carcinoma                 |                                                       X                  |          2 |
      Keratoacanthoma                      |                                                                          |          1 |
      Leukemia Mononuclear                 |                                        X                                 |          5 |
      Squamous Cell Papilloma              |                                                    X                     |          1 |
      Trichoepithelioma                    |                                                                          |          1 |
      Subcutaneous Tissue, Fibroma         |                                                                          |          2 |
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |          1 |
      Subcutaneous Tissue, Leukemia        |                                                                          |            |
          Mononuclear                      |                                                                          |          1 |
      Subcutaneous Tissue, Lipoma          |                                                                          |          1 |
      Subcutaneous Tissue, Sarcoma         |                                                          X               |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  59                                                               
NTP Experiment-Test: 05061-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 17:56:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 5| 4| 7| 4| 7| 5| 4| 7| 7| 4| 5| 2| 7| 7| 7| 7| 5|              |            |
                             DAY ON TEST   | 5| 3| 2| 4| 2| 3| 2| 3| 7| 5| 3| 3| 5| 7| 7| 3| 3| 3| 3| 6|              |            |
                                           | 8| 4| 1| 9| 1| 4| 7| 4| 4| 6| 1| 1| 6| 3| 5| 4| 1| 3| 5| 2|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |     A      |
    UNTREATE                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |     L      |
    D 71 UM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |       +                                                                  |   2        |
      Abdominal, Mesothelioma Malignant    |                                                                          |          1 |
      Intercostal, Leukemia Mononuclear    |       X                                                                  |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Leukemia Mononuclear                 |       X                                X        X                        |          8 |
      Oligodendroglioma Benign             |                   X                                                      |          1 |
      Cerebrum, Meningioma Benign          |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                        +                                 |   5        |
      Leukemia Mononuclear                 |                                        X                                 |          2 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Alveolar/Bronchiolar Adenoma         |                                                                          |          1 |
      Leukemia Mononuclear                 |       X              X           X     X        X                        |         20 |
      Pheochromocytoma Malignant,          |                                                                          |            |
          Metastatic, Adrenal Medulla      |                                                                          |          1 |
      Sarcoma, Metastatic, Skin            |                                                          X               |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +               |  68        |
      Leukemia Mononuclear                 |                                  X              X                        |          9 |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Leukemia Mononuclear                 |       X                                                                  |          1 |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                           +                              |   4        |
      Fibrosarcoma                         |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Eye                                     |          +           +                 +                                 |   6        |
      Leukemia Mononuclear                 |                                        X                                 |          1 |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
      Carcinoma                            |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Leukemia Mononuclear                 |       X                          X     X        X                        |         14 |
      Renal Tubule, Adenoma                |                X                                                         |          2 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Leukemia Mononuclear                 |       X                                X        X                        |          6 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  60                                                               
NTP Experiment-Test: 05061-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 17:56:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 5| 4| 7| 4| 7| 5| 4| 7| 7| 4| 5| 2| 7| 7| 7| 7| 5|              |            |
                             DAY ON TEST   | 5| 3| 2| 4| 2| 3| 2| 3| 7| 5| 3| 3| 5| 7| 7| 3| 3| 3| 3| 6|              |            |
                                           | 8| 4| 1| 9| 1| 4| 7| 4| 4| 6| 1| 1| 6| 3| 5| 4| 1| 3| 5| 2|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |     A      |
    UNTREATE                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |     L      |
    D 71 UM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Leukemia Mononuclear                 |       X              X        X  X     X        X     X                  |         25 |
      Mesothelioma Malignant               |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  61                                                               
NTP Experiment-Test: 05061-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 17:56:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 2| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 2| 7| 7| 7| 7| 2|             
                             DAY ON TEST   | 3| 3| 7| 0| 7| 3| 3| 1| 5| 1| 3| 3| 3| 2| 9| 3| 3| 3| 2| 7| 3| 3| 3| 3| 7|             
                                           | 1| 1| 3| 4| 6| 4| 4| 8| 3| 8| 4| 4| 4| 0| 3| 1| 1| 1| 9| 6| 1| 1| 1| 1| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.2%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
     71LM                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Polyp Adenomatous                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma                       |                      X                                                   |             
      Polyp Adenomatous                    | X                 X                    X                       X         |             
      Polyp Adenomatous, Multiple          |                                                                   X      |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Carcinoma             | X                                      X           X           X  X      |             
      Hepatocellular Carcinoma, Multiple   |                X                                                         |             
      Hepatocellular Adenoma               | X              X  X                    X           X              X  X   |             
      Hepatocellular Adenoma, Multiple     |    X                             X  X           X           X  X         |             
      Leukemia Mononuclear                 | X        X                                                  X  X         |             
      Mesothelioma Malignant               |                                                 X                        |             
                                            __________________________________________________________________________|             
   Mesentery                               |             M                                            M              M|             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X                                                               |             
      Mesothelioma Malignant               |                                                 X                        |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Squamous Cell Papilloma              |    X                                                                     |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X                                                               |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X                                                               |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X                                                               |             
      Pheochromocytoma Malignant           |                         X                          X                     |             
      Pheochromocytoma Benign              | X                             X     X     X     X     X              X   |             
      Bilateral, Pheochromocytoma Benign   |                X                                                         |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +   |             
      Adenoma                              | X                                                                        |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  M  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               |    X  X  X        X                                   X              X   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  62                                                               
NTP Experiment-Test: 05061-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 17:56:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 2| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 2| 7| 7| 7| 7| 2|             
                             DAY ON TEST   | 3| 3| 7| 0| 7| 3| 3| 1| 5| 1| 3| 3| 3| 2| 9| 3| 3| 3| 2| 7| 3| 3| 3| 3| 7|             
                                           | 1| 1| 3| 4| 6| 4| 4| 8| 3| 8| 4| 4| 4| 0| 3| 1| 1| 1| 9| 6| 1| 1| 1| 1| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.2%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
     71LM                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pars Distalis, Adenoma, Multiple     |                                                             X            |             
      Pars Distalis, Carcinoma             |                            X                                             |             
      Pars Distalis, Leukemia Mononuclear  |          X                                                               |             
      Pars Intermedia, Adenoma             |                                                                X         |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Adenoma                      | X                                            X  X                    X   |             
      Follicular Cell, Carcinoma           |    X                                               X                     |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       |       +                                                                  |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mesothelioma Malignant               |                                                 X                        |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                    X                     |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bilateral, Interstitial Cell, Adenoma| X     X  X     X  X     X  X  X  X  X  X  X  X  X  X           X  X  X   |             
      Interstitial Cell, Adenoma           |    X                 X                                      X            |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X                                                               |             
                                            __________________________________________________________________________|             
   Lymph Node                              |          +  M           +                    +        +  M               |             
      Pancreatic, Leukemia Mononuclear     |          X                                                               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X                                                               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X                                                               |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X                                                  X  X         |             
      Mesothelioma Malignant               |                                                 X                        |             
      Sarcoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  M  +  +  +  +  +  M  +  +  +  M  M  +  +  M  M  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  +  +  +  M  M  +  M  M  +  M  +  M  M  +  M  +  +  +  M  +  +  M  +  +|             
      Fibroadenoma                         |                   X                                                      |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  I  +  +  +  +  +  +  +  +  +|             
      Keratoacanthoma                      |                                                       X                  |             
      Pinna, Squamous Cell Papilloma       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  63                                                               
NTP Experiment-Test: 05061-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 17:56:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 2| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 2| 7| 7| 7| 7| 2|             
                             DAY ON TEST   | 3| 3| 7| 0| 7| 3| 3| 1| 5| 1| 3| 3| 3| 2| 9| 3| 3| 3| 2| 7| 3| 3| 3| 3| 7|             
                                           | 1| 1| 3| 4| 6| 4| 4| 8| 3| 8| 4| 4| 4| 0| 3| 1| 1| 1| 9| 6| 1| 1| 1| 1| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.2%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
     71LM                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Subcutaneous Tissue, Sarcoma         |                               X        X                                 |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Pituitary     |                                                                          |             
          Gland                            |                            X                                             |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |          +                                                               |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                                                          |             
      Alveolar/Bronchiolar Carcinoma       |                                        X                                 |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                   X      |             
      Leukemia Mononuclear                 |          X                                                  X  X         |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                      +  +  +           +        +     +                  |             
                                            __________________________________________________________________________|             
   Eye                                     |                         I                                                |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                       +                  |             
      Carcinoma                            |                                                       X                  |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                          |             
      Leukemia Mononuclear                 |          X                                                               |             
      Renal Tubule, Adenoma                |                   X        X                                         X   |             
      Renal Tubule, Adenoma, Multiple      | X     X                                            X                     |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Mesothelioma Malignant               |                                                 X                        |             
      Transitional Epithelium, Papilloma   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X        X                                                  X  X         |             
      Mesothelioma Malignant               |                                                 X                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  64                                                               
NTP Experiment-Test: 05061-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 17:56:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 6| 2| 7| 7| 7| 6| 2| 6| 6| 2| 2| 2| 7| 7| 7| 7| 7| 7| 6| 6| 2| 2|            |
                             DAY ON TEST   | 3| 0| 7| 5| 7| 3| 3| 3| 7| 7| 5| 4| 7| 7| 7| 3| 3| 3| 3| 3| 3| 9| 6| 7| 7|            |
                                           | 1| 0| 4| 9| 6| 4| 4| 4| 5| 4| 0| 0| 6| 5| 4| 1| 1| 0| 0| 0| 4| 4| 8| 4| 6|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|     A      |
    0.2%                                   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|     L      |
     71LM                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Polyp Adenomatous                    |                                              X                           |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Adenocarcinoma                       |                                                                          |          1 |
      Polyp Adenomatous                    | X  X     X              X                    X  X     X  X               |         12 |
      Polyp Adenomatous, Multiple          |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hepatocellular Carcinoma             |       X        X              X                    X     X  X            |         11 |
      Hepatocellular Carcinoma, Multiple   |                                                                          |          1 |
      Hepatocellular Adenoma               |                         X                    X     X                     |         10 |
      Hepatocellular Adenoma, Multiple     | X  X                                                  X        X         |         10 |
      Leukemia Mononuclear                 |                      X                                                   |          5 |
      Mesothelioma Malignant               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |       +     M     +        +        M  M  M                          M  M|   3        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Mesothelioma Malignant               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Squamous Cell Papilloma              |    X                                                                     |          2 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                      X                                                   |          2 |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                      X                                                   |          2 |
      Pheochromocytoma Malignant           |                                                                          |          2 |
      Pheochromocytoma Benign              | X  X                    X        X                                X      |         12 |
      Bilateral, Pheochromocytoma Benign   |          X                                                     X         |          3 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  65                                                               
NTP Experiment-Test: 05061-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 17:56:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 6| 2| 7| 7| 7| 6| 2| 6| 6| 2| 2| 2| 7| 7| 7| 7| 7| 7| 6| 6| 2| 2|            |
                             DAY ON TEST   | 3| 0| 7| 5| 7| 3| 3| 3| 7| 7| 5| 4| 7| 7| 7| 3| 3| 3| 3| 3| 3| 9| 6| 7| 7|            |
                                           | 1| 0| 4| 9| 6| 4| 4| 4| 5| 4| 0| 0| 6| 5| 4| 1| 1| 0| 0| 0| 4| 4| 8| 4| 6|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|     A      |
    0.2%                                   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|     L      |
     71LM                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +     +  +  +  +     +  +           +  +  +  +  +  +  +  +      |  40        |
      Adenoma                              |                         X                                                |          2 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pars Distalis, Adenoma               |       X                 X     X  X              X                 X      |         12 |
      Pars Distalis, Adenoma, Multiple     |                   X                                                      |          2 |
      Pars Distalis, Carcinoma             |                                                                          |          1 |
      Pars Distalis, Leukemia Mononuclear  |                                                                          |          1 |
      Pars Intermedia, Adenoma             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      C-Cell, Adenoma                      |                      X                                                   |          5 |
      Follicular Cell, Carcinoma           |                                                          X               |          3 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Coagulating Gland                       |                                                       +                  |   2        |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mesothelioma Malignant               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Adenoma                              |          X                                                               |          2 |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Bilateral, Interstitial Cell, Adenoma| X  X  X  X     X  X  X        X              X  X  X  X  X  X  X  X      |         34 |
      Interstitial Cell, Adenoma           |                                                                          |          3 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |             +              M     +  M  M  M                          M  M|   6        |
      Pancreatic, Leukemia Mononuclear     |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                      X                                                   |          4 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  66                                                               
NTP Experiment-Test: 05061-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 17:56:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 6| 2| 7| 7| 7| 6| 2| 6| 6| 2| 2| 2| 7| 7| 7| 7| 7| 7| 6| 6| 2| 2|            |
                             DAY ON TEST   | 3| 0| 7| 5| 7| 3| 3| 3| 7| 7| 5| 4| 7| 7| 7| 3| 3| 3| 3| 3| 3| 9| 6| 7| 7|            |
                                           | 1| 0| 4| 9| 6| 4| 4| 4| 5| 4| 0| 0| 6| 5| 4| 1| 1| 0| 0| 0| 4| 4| 8| 4| 6|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|     A      |
    0.2%                                   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|     L      |
     71LM                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Mesothelioma Malignant               |                                                                          |          1 |
      Sarcoma                              | X                                                                        |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  M  +  +|  41        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  M  +  +  M  M  M  M  +  +  M  +  +  +  +  +  +  M  M  +  +  M  M  +|  29        |
      Fibroadenoma                         |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Keratoacanthoma                      |                                                                          |          1 |
      Pinna, Squamous Cell Papilloma       |    X                 X                                                   |          2 |
      Subcutaneous Tissue, Sarcoma         |                         X                                                |          3 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |       +                                                                  |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Carcinoma, Metastatic, Pituitary     |                                                                          |            |
          Gland                            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Alveolar/Bronchiolar Adenoma         | X                                                           X            |          2 |
      Alveolar/Bronchiolar Carcinoma       |                                                                          |          1 |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |                                                                          |          1 |
      Leukemia Mononuclear                 |                      X                                                   |          4 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |          +                                                               |   7        |
                                            __________________________________________________________________________|____________|
   Eye                                     |                   +                             +  +                     |   3        |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
      Carcinoma                            |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  67                                                               
NTP Experiment-Test: 05061-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 17:56:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 6| 2| 7| 7| 7| 6| 2| 6| 6| 2| 2| 2| 7| 7| 7| 7| 7| 7| 6| 6| 2| 2|            |
                             DAY ON TEST   | 3| 0| 7| 5| 7| 3| 3| 3| 7| 7| 5| 4| 7| 7| 7| 3| 3| 3| 3| 3| 3| 9| 6| 7| 7|            |
                                           | 1| 0| 4| 9| 6| 4| 4| 4| 5| 4| 0| 0| 6| 5| 4| 1| 1| 0| 0| 0| 4| 4| 8| 4| 6|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|     A      |
    0.2%                                   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|     L      |
     71LM                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |                               X                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Renal Tubule, Adenoma                |          X              X                    X                           |          6 |
      Renal Tubule, Adenoma, Multiple      |                                                       X                  |          4 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  48        |
      Mesothelioma Malignant               |                                                                          |          1 |
      Transitional Epithelium, Papilloma   |    X                                                                     |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                      X                                                   |          5 |
      Mesothelioma Malignant               |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  68                                                               
NTP Experiment-Test: 05061-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 17:56:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 6| 7| 7| 5| 2| 2| 7| 7| 6| 6| 5| 7| 7| 7| 7| 6| 7| 7| 6| 6| 2|             
                             DAY ON TEST   | 2| 2| 2| 6| 5| 2| 1| 2| 7| 7| 2| 2| 9| 7| 7| 2| 2| 2| 1| 5| 2| 2| 2| 0| 7|             
                                           | 9| 9| 0| 1| 3| 9| 2| 1| 4| 4| 9| 9| 3| 4| 6| 9| 9| 9| 4| 0| 9| 9| 3| 9| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.5%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    71MLM                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma                       |                                                                          |             
      Polyp Adenomatous, Multiple          |       X                                                                  |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma                       |             X  X                                                         |             
      Polyp Adenomatous                    |                X                       X     X           X     X     X   |             
      Polyp Adenomatous, Multiple          | X  X  X  X  X     X           X  X  X           X  X  X     X            |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cholangioma                          |                                                          X               |             
      Hepatocellular Carcinoma             |          X        X           X        X  X  X  X                        |             
      Hepatocellular Carcinoma, Multiple   | X  X  X     X  X                 X  X              X  X  X  X  X  X  X   |             
      Hepatocellular Adenoma               | X     X     X     X  X                    X  X           X           X   |             
      Hepatocellular Adenoma, Multiple     |    X                             X  X  X        X  X        X  X         |             
      Hepatocholangiocarcinoma             |    X                             X                                       |             
      Hepatocholangiocarcinoma, Multiple   |                                                                          |             
      Hepatocholangioma                    |                                                                          |             
      Leukemia Mononuclear                 |                                                          X               |             
      Myxoma                               |    X                                                                     |             
                                            __________________________________________________________________________|             
   Mesentery                               |    +                                            +                        |             
      Mesothelioma Malignant               |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mesothelioma Malignant               |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Submandibular Gland, Leukemia        |                                                                          |             
          Mononuclear                      |                                                          X               |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mesothelioma Malignant               |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mesothelioma Malignant               |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                           +                              |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                          X               |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                          X               |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  69                                                               
NTP Experiment-Test: 05061-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 17:56:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 6| 7| 7| 5| 2| 2| 7| 7| 6| 6| 5| 7| 7| 7| 7| 6| 7| 7| 6| 6| 2|             
                             DAY ON TEST   | 2| 2| 2| 6| 5| 2| 1| 2| 7| 7| 2| 2| 9| 7| 7| 2| 2| 2| 1| 5| 2| 2| 2| 0| 7|             
                                           | 9| 9| 0| 1| 3| 9| 2| 1| 4| 4| 9| 9| 3| 4| 6| 9| 9| 9| 4| 0| 9| 9| 3| 9| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.5%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    71MLM                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Ganglioneuroma                       |                                                                          |             
      Pheochromocytoma Malignant           |                                     X                                    |             
      Pheochromocytoma Benign              |             X     X  X                          X        X               |             
      Bilateral, Pheochromocytoma Benign   |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +|             
      Adenoma                              |                                              X                           |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               |                   X                 X           X              X         |             
      Pars Distalis, Adenoma, Multiple     |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Adenoma                      | X                                                                        |             
      Follicular Cell, Adenoma             |                                                                          |             
      Follicular Cell, Carcinoma           |                                                                   X      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mesothelioma Malignant               |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Adenocarcinoma                       |                                                                          |             
      Adenoma                              |                                                          X               |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mesothelioma Malignant               |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mesothelioma Malignant               |                                                                          |             
      Bilateral, Interstitial Cell, Adenoma| X  X  X  X  X     X  X        X  X  X     X  X  X  X  X  X  X     X  X   |             
      Interstitial Cell, Adenoma           |                X                       X                       X         |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |                         +  M     +              +     +                 +|             
      Lumbar, Adenocarcinoma, Metastatic,  |                                                                          |             
           Intestine Large, Rectum         |                                                                          |             
      Pancreatic, Leukemia Mononuclear     |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma, Metastatic,          |                                                                          |             
          Intestine Large, Colon           |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibroma                              |                                  X                                       |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  70                                                               
NTP Experiment-Test: 05061-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 17:56:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 6| 7| 7| 5| 2| 2| 7| 7| 6| 6| 5| 7| 7| 7| 7| 6| 7| 7| 6| 6| 2|             
                             DAY ON TEST   | 2| 2| 2| 6| 5| 2| 1| 2| 7| 7| 2| 2| 9| 7| 7| 2| 2| 2| 1| 5| 2| 2| 2| 0| 7|             
                                           | 9| 9| 0| 1| 3| 9| 2| 1| 4| 4| 9| 9| 3| 4| 6| 9| 9| 9| 4| 0| 9| 9| 3| 9| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.5%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    71MLM                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Leukemia Mononuclear                 |                                                          X               |             
      Mesothelioma Malignant               |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  M  +  M  M  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Thymoma Benign                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  +  M  M  M  +  M  +  M  M  +  +  +  M  +  M  M  M  M  M  +  +  +|             
      Adenocarcinoma                       |                                        X                                 |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basal Cell Adenoma                   |       X                                                                  |             
      Squamous Cell Papilloma              |                                     X                                    |             
      Pinna, Squamous Cell Papilloma       |                   X                                                      |             
      Subcutaneous Tissue, Fibroma         |                                                                          |             
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |             
      Subcutaneous Tissue, Sarcoma         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                     +                                    |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Meninges, Granular Cell Tumor Benign |       X                                                                  |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |       +                                                                  |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Uncertain Primary Site          |       X                                                                  |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma, Metastatic, Kidney   |                                                                          |             
      Adenocarcinoma, Metastatic,          |                                                                          |             
          Intestine Large, Colon           |                                                                          |             
      Alveolar/Bronchiolar Adenoma         |    X        X                                                            |             
      Alveolar/Bronchiolar Carcinoma       |                                                                          |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |       X  X                    X                                   X      |             
      Leukemia Mononuclear                 |                                                          X               |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  71                                                               
NTP Experiment-Test: 05061-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 17:56:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 6| 7| 7| 5| 2| 2| 7| 7| 6| 6| 5| 7| 7| 7| 7| 6| 7| 7| 6| 6| 2|             
                             DAY ON TEST   | 2| 2| 2| 6| 5| 2| 1| 2| 7| 7| 2| 2| 9| 7| 7| 2| 2| 2| 1| 5| 2| 2| 2| 0| 7|             
                                           | 9| 9| 0| 1| 3| 9| 2| 1| 4| 4| 9| 9| 3| 4| 6| 9| 9| 9| 4| 0| 9| 9| 3| 9| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.5%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    71MLM                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                           +                              |             
      Squamous Cell Carcinoma              |                                           X                              |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                          X               |             
      Pelvis, Transitional Epithelium,     |                                                                          |             
           Papilloma                       |                                                                          |             
      Renal Tubule, Adenoma                |                X                             X                           |             
      Renal Tubule, Adenoma, Multiple      |                                     X                                    |             
      Renal Tubule, Carcinoma              |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mesothelioma Malignant               |                                                                          |             
      Transitional Epithelium, Carcinoma   |       X                                                                  |             
      Transitional Epithelium, Papilloma   |                                                             X  X         |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                          X               |             
      Mesothelioma Malignant               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  72                                                               
NTP Experiment-Test: 05061-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 17:56:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 2| 7| 7| 6| 6| 2| 6| 5| 4| 2| 2| 7| 6| 6| 5| 2| 6| 6| 6| 2| 2|             
                             DAY ON TEST   | 2| 2| 0| 6| 7| 2| 0| 7| 2| 7| 5| 8| 7| 7| 7| 3| 7| 3| 8| 7| 5| 3| 3| 7| 7|             
                                           | 9| 9| 0| 3| 6| 9| 2| 4| 9| 5| 0| 4| 8| 4| 4| 0| 4| 7| 2| 6| 9| 6| 6| 5| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.5%                                   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    71MLM                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma                       |                                                                          |             
      Polyp Adenomatous, Multiple          |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma                       | X  X                    X                                   X            |             
      Polyp Adenomatous                    |                X                 X  X           X     X     X  X         |             
      Polyp Adenomatous, Multiple          | X  X  X           X     X     X              X     X              X      |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cholangioma                          |                X                                                         |             
      Hepatocellular Carcinoma             |                                                                X         |             
      Hepatocellular Carcinoma, Multiple   | X  X  X  X     X  X  X        X     X        X  X  X  X     X     X      |             
      Hepatocellular Adenoma               |                      X     X                                             |             
      Hepatocellular Adenoma, Multiple     | X  X  X        X  X     X                    X  X  X  X                  |             
      Hepatocholangiocarcinoma             |          X                                                               |             
      Hepatocholangiocarcinoma, Multiple   |                         X                                                |             
      Hepatocholangioma                    |                                                                          |             
      Leukemia Mononuclear                 |                                              X                           |             
      Myxoma                               |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                   +                                                      |             
      Mesothelioma Malignant               |                   X                                                      |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mesothelioma Malignant               |                   X                                                      |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Submandibular Gland, Leukemia        |                                                                          |             
          Mononuclear                      |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mesothelioma Malignant               |                   X                                                      |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mesothelioma Malignant               |                   X                                                      |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                    +                     |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  73                                                               
NTP Experiment-Test: 05061-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 17:56:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 2| 7| 7| 6| 6| 2| 6| 5| 4| 2| 2| 7| 6| 6| 5| 2| 6| 6| 6| 2| 2|             
                             DAY ON TEST   | 2| 2| 0| 6| 7| 2| 0| 7| 2| 7| 5| 8| 7| 7| 7| 3| 7| 3| 8| 7| 5| 3| 3| 7| 7|             
                                           | 9| 9| 0| 3| 6| 9| 2| 4| 9| 5| 0| 4| 8| 4| 4| 0| 4| 7| 2| 6| 9| 6| 6| 5| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.5%                                   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    71MLM                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Ganglioneuroma                       |                                                                         X|             
      Pheochromocytoma Malignant           |                                                                          |             
      Pheochromocytoma Benign              |    X  X           X                                   X                  |             
      Bilateral, Pheochromocytoma Benign   | X                                                                        |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +     +  +  +  +     +  +  A        +  +  +  +     +  +  +      |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               |                                                                          |             
      Pars Distalis, Adenoma, Multiple     |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Adenoma                      |                   X                                                      |             
      Follicular Cell, Adenoma             |                                                                X         |             
      Follicular Cell, Carcinoma           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mesothelioma Malignant               |                   X                                                      |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma                       |       X                                                                  |             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mesothelioma Malignant               |                   X                                                      |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mesothelioma Malignant               |                   X                                                      |             
      Bilateral, Interstitial Cell, Adenoma| X  X  X  X     X  X  X  X     X  X           X  X  X  X        X  X      |             
      Interstitial Cell, Adenoma           |                                                             X            |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +           M  +        +  M           +  +              +     +     +  M|             
      Lumbar, Adenocarcinoma, Metastatic,  |                                                                          |             
           Intestine Large, Rectum         |                                                                          |             
      Pancreatic, Leukemia Mononuclear     |                X                                                         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  M  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma, Metastatic,          |                                                                          |             
          Intestine Large, Colon           |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibroma                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  74                                                               
NTP Experiment-Test: 05061-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 17:56:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 2| 7| 7| 6| 6| 2| 6| 5| 4| 2| 2| 7| 6| 6| 5| 2| 6| 6| 6| 2| 2|             
                             DAY ON TEST   | 2| 2| 0| 6| 7| 2| 0| 7| 2| 7| 5| 8| 7| 7| 7| 3| 7| 3| 8| 7| 5| 3| 3| 7| 7|             
                                           | 9| 9| 0| 3| 6| 9| 2| 4| 9| 5| 0| 4| 8| 4| 4| 0| 4| 7| 2| 6| 9| 6| 6| 5| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.5%                                   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    71MLM                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
      Mesothelioma Malignant               |                   X                                                      |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  M  +  +  +  +  +  +  M  M  M  +  +  +  +  +  M  +  +  +  +  +  +|             
      Thymoma Benign                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  M  +  M  +  +  M  +  +  +  M  +  M  M  M  +  M  +  +  M  +  +  M  +  M|             
      Adenocarcinoma                       |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basal Cell Adenoma                   |                                                                          |             
      Squamous Cell Papilloma              | X                                                                        |             
      Pinna, Squamous Cell Papilloma       |                                                                          |             
      Subcutaneous Tissue, Fibroma         |                                                                          |             
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |             
      Subcutaneous Tissue, Sarcoma         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Meninges, Granular Cell Tumor Benign |                                                                          |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                      +                                                   |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Uncertain Primary Site          |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                      +                                                   |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma, Metastatic, Kidney   |                                                 X                        |             
      Adenocarcinoma, Metastatic,          |                                                                          |             
          Intestine Large, Colon           |                                                                          |             
      Alveolar/Bronchiolar Adenoma         |                                                                          |             
      Alveolar/Bronchiolar Carcinoma       |                X                                                         |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |    X  X  X                          X           X           X     X      |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                         +                                                |             
                                            __________________________________________________________________________|             
   Eye                                     |                         +                                                |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  75                                                               
NTP Experiment-Test: 05061-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 17:56:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 2| 7| 7| 6| 6| 2| 6| 5| 4| 2| 2| 7| 6| 6| 5| 2| 6| 6| 6| 2| 2|             
                             DAY ON TEST   | 2| 2| 0| 6| 7| 2| 0| 7| 2| 7| 5| 8| 7| 7| 7| 3| 7| 3| 8| 7| 5| 3| 3| 7| 7|             
                                           | 9| 9| 0| 3| 6| 9| 2| 4| 9| 5| 0| 4| 8| 4| 4| 0| 4| 7| 2| 6| 9| 6| 6| 5| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.5%                                   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    71MLM                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
      Squamous Cell Carcinoma              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Pelvis, Transitional Epithelium,     |                                                                          |             
           Papilloma                       |                         X                                                |             
      Renal Tubule, Adenoma                |    X                 X                                         X         |             
      Renal Tubule, Adenoma, Multiple      |                   X           X                                          |             
      Renal Tubule, Carcinoma              |                                                 X                        |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mesothelioma Malignant               |                   X                                                      |             
      Transitional Epithelium, Carcinoma   |                                                                          |             
      Transitional Epithelium, Papilloma   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                X                             X                           |             
      Mesothelioma Malignant               |                   X                                                      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  76                                                               
NTP Experiment-Test: 05061-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 17:56:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 5| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 6| 6| 6|              |            |
                             DAY ON TEST   | 3| 8| 2| 2| 6| 3| 3| 2| 1| 0| 3| 3| 0| 9| 0| 3| 3| 8| 5| 0|              |            |
                                           | 0| 5| 9| 1| 5| 0| 0| 8| 5| 9| 0| 0| 0| 8| 8| 0| 0| 7| 2| 5|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|              |     A      |
    0.5%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|              |     L      |
    71MLM                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +               |  68        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +               |  69        |
      Adenocarcinoma                       |                               X                                          |          1 |
      Polyp Adenomatous, Multiple          |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +               |  68        |
      Adenocarcinoma                       | X                                         X     X     X                  |         10 |
      Polyp Adenomatous                    |    X     X                    X              X                           |         17 |
      Polyp Adenomatous, Multiple          | X     X        X  X  X  X  X     X  X           X  X  X                  |         34 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +               |  69        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +               |  69        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  M  +  +  +  +  +  +     +  +  +  +  +  +               |  67        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +               |  67        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +               |  69        |
      Cholangioma                          |                                                                          |          2 |
      Hepatocellular Carcinoma             | X           X        X                    X                              |         12 |
      Hepatocellular Carcinoma, Multiple   |    X  X  X     X  X     X     X  X  X        X  X  X  X  X               |         43 |
      Hepatocellular Adenoma               | X        X                       X  X           X  X  X                  |         18 |
      Hepatocellular Adenoma, Multiple     |       X        X  X     X                    X                           |         23 |
      Hepatocholangiocarcinoma             |                            X        X                                    |          5 |
      Hepatocholangiocarcinoma, Multiple   |                                                                          |          1 |
      Hepatocholangioma                    |       X                                                                  |          1 |
      Leukemia Mononuclear                 |                                                                          |          2 |
      Myxoma                               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |          +                                                               |   4        |
      Mesothelioma Malignant               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +               |  69        |
      Mesothelioma Malignant               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +               |  68        |
      Submandibular Gland, Leukemia        |                                                                          |            |
          Mononuclear                      |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +               |  69        |
      Mesothelioma Malignant               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +               |  69        |
      Mesothelioma Malignant               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +               |  69        |
      Leukemia Mononuclear                 |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  77                                                               
NTP Experiment-Test: 05061-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 17:56:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 5| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 6| 6| 6|              |            |
                             DAY ON TEST   | 3| 8| 2| 2| 6| 3| 3| 2| 1| 0| 3| 3| 0| 9| 0| 3| 3| 8| 5| 0|              |            |
                                           | 0| 5| 9| 1| 5| 0| 0| 8| 5| 9| 0| 0| 0| 8| 8| 0| 0| 7| 2| 5|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|              |     A      |
    0.5%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|              |     L      |
    71MLM                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  M  +  +  +  +  +  +     +  +  +  +  +  +               |  68        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  M  +  +  +  +  +  +     +  +  +  +  +  +               |  68        |
      Ganglioneuroma                       |                                                                          |          1 |
      Pheochromocytoma Malignant           |                                                                          |          1 |
      Pheochromocytoma Benign              |                            X                       X                     |         11 |
      Bilateral, Pheochromocytoma Benign   |                               X                                          |          2 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +               |  58        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +     M  +  +  +  +  +               |  65        |
      Adenoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  M  +  +  +  +     +  +  +  +  +  +               |  65        |
      Pars Distalis, Adenoma               |                            X  X     X           X     X                  |          9 |
      Pars Distalis, Adenoma, Multiple     |                                           X                              |          1 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +               |  69        |
      C-Cell, Adenoma                      |                            X                                             |          3 |
      Follicular Cell, Adenoma             |                               X                                          |          2 |
      Follicular Cell, Carcinoma           |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +               |  69        |
      Mesothelioma Malignant               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +               |  66        |
      Adenocarcinoma                       |                                                                          |          1 |
      Adenoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +               |  68        |
      Mesothelioma Malignant               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +               |  69        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +               |  69        |
      Mesothelioma Malignant               |                                                                          |          1 |
      Bilateral, Interstitial Cell, Adenoma| X  X  X  X     X     X  X     X  X        X  X  X  X     X               |         49 |
      Interstitial Cell, Adenoma           |                   X                 X                                    |          6 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +               |  69        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  78                                                               
NTP Experiment-Test: 05061-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 17:56:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 5| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 6| 6| 6|              |            |
                             DAY ON TEST   | 3| 8| 2| 2| 6| 3| 3| 2| 1| 0| 3| 3| 0| 9| 0| 3| 3| 8| 5| 0|              |            |
                                           | 0| 5| 9| 1| 5| 0| 0| 8| 5| 9| 0| 0| 0| 8| 8| 0| 0| 7| 2| 5|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|              |     A      |
    0.5%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|              |     L      |
    71MLM                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |          +        +                       +  +           +               |  18        |
      Lumbar, Adenocarcinoma, Metastatic,  |                                                                          |            |
           Intestine Large, Rectum         |                                           X                              |          1 |
      Pancreatic, Leukemia Mononuclear     |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  M  +  +  +  +  +  +  +  M  +  +  +     +  +  +  +  +  +               |  64        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  M     +  +  +  +  +  +               |  67        |
      Adenocarcinoma, Metastatic,          |                                                                          |            |
          Intestine Large, Colon           |                               X                                          |          1 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  M  +  +  +  +  +     +  +  +  +  +  +               |  68        |
      Fibroma                              |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Mesothelioma Malignant               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  M  +  +  +  +  +  M  +  M  +  +  M     M  +  M  +  M  M               |  51        |
      Thymoma Benign                       |                X                                                         |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  M  M  +  M  +  +  +  M  M  M  +  M     +  +  +  M  M  +               |  34        |
      Adenocarcinoma                       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +               |  68        |
      Basal Cell Adenoma                   |                                                                          |          1 |
      Squamous Cell Papilloma              |                            X                                             |          3 |
      Pinna, Squamous Cell Papilloma       |                X                                                         |          2 |
      Subcutaneous Tissue, Fibroma         |                   X  X  X                                                |          3 |
      Subcutaneous Tissue, Fibrosarcoma    |             X                                                            |          1 |
      Subcutaneous Tissue, Sarcoma         |    X                                                                     |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +               |  69        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +               |  69        |
      Meninges, Granular Cell Tumor Benign |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |                                                                          |   2        |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Uncertain Primary Site          |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  79                                                               
NTP Experiment-Test: 05061-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 17:56:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 5| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 6| 6| 6|              |            |
                             DAY ON TEST   | 3| 8| 2| 2| 6| 3| 3| 2| 1| 0| 3| 3| 0| 9| 0| 3| 3| 8| 5| 0|              |            |
                                           | 0| 5| 9| 1| 5| 0| 0| 8| 5| 9| 0| 0| 0| 8| 8| 0| 0| 7| 2| 5|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|              |     A      |
    0.5%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|              |     L      |
    71MLM                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +               |  69        |
      Adenocarcinoma, Metastatic, Kidney   |                                                                          |          1 |
      Adenocarcinoma, Metastatic,          |                                                                          |            |
          Intestine Large, Colon           |                               X                                          |          1 |
      Alveolar/Bronchiolar Adenoma         |                                                                          |          2 |
      Alveolar/Bronchiolar Carcinoma       |                   X                                                      |          2 |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           | X  X  X  X                       X                    X  X               |         18 |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +               |  69        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +               |  69        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     | +                                                                        |   2        |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
      Squamous Cell Carcinoma              |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +               |  69        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Pelvis, Transitional Epithelium,     |                                                                          |            |
           Papilloma                       |                                                                          |          1 |
      Renal Tubule, Adenoma                |                               X                    X                     |          7 |
      Renal Tubule, Adenoma, Multiple      |                            X                                             |          4 |
      Renal Tubule, Carcinoma              |                      X                                                   |          2 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +               |  67        |
      Mesothelioma Malignant               |                                                                          |          1 |
      Transitional Epithelium, Carcinoma   |                                                                          |          1 |
      Transitional Epithelium, Papilloma   |                                                                          |          2 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +               |  69        |
      Leukemia Mononuclear                 |                                                                          |          3 |
      Mesothelioma Malignant               |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  80                                                               
NTP Experiment-Test: 05061-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 17:56:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 4| 5| 4| 7| 4| 4| 6| 2| 4| 7| 7| 6| 2| 7| 6| 5| 2| 2| 6| 4| 5| 4| 2|             
                             DAY ON TEST   | 0| 9| 5| 5| 9| 2| 5| 5| 7| 7| 5| 2| 2| 2| 7| 2| 1| 8| 7| 7| 3| 5| 9| 7| 7|             
                                           | 9| 6| 8| 3| 3| 9| 6| 8| 9| 4| 6| 9| 9| 4| 4| 1| 0| 1| 6| 6| 1| 8| 0| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    1.0%                                   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    71MHM                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +     +  +  +        +  +     +  +  +  +  +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +        +  +     +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Adenocarcinoma                       |                                                                   X      |             
      Polyp Adenomatous, Multiple          |                                  X                                X      |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma                       |             X                                                            |             
      Adenocarcinoma, Multiple             |    X                                         X     X                     |             
      Polyp Adenomatous                    |       X              X        X  X                             X  X      |             
      Polyp Adenomatous, Multiple          | X              X        X           X  X     X  X  X        X            |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +     +  +  +        +  +     +  +  +  +  +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +     +  +  +        +  +     +  +  +  +  +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +     A  +  +        +  +     +  +  +  +  +  +  +  +  +  +     A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +     +  +  +        +  +     +  +  +  +  +  +  +  +  +  +     A  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cholangiocarcinoma                   |                                                                          |             
      Hepatocellular Carcinoma             |                   X     X                       X           X  X     X   |             
      Hepatocellular Carcinoma, Multiple   | X  X     X  X  X     X           X  X  X     X     X              X      |             
      Hepatocellular Adenoma               |    X           X              X                 X                        |             
      Hepatocellular Adenoma, Multiple     | X     X                 X        X  X  X     X              X            |             
      Hepatocholangiocarcinoma             |                                                                          |             
      Hepatocholangioma                    |                                                                          |             
      Leukemia Mononuclear                 |                                                                   X      |             
                                            __________________________________________________________________________|             
   Mesentery                               |          +                 M        +     M           M  M              M|             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +     +  +  +        +  +     +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Adenocarcinoma, Metastatic,          |                                                                          |             
          Intestine Large, Rectum          |             X                                                            |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +     +  +  +        +  +     +  +  +  +  +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Squamous Cell Carcinoma              |                                                                          |             
      Squamous Cell Papilloma              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +     +  +  +        +  +     +  +  +  +  +  +  +  +  +  +     +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +     +  +  +        +  +     +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           | X                                                                        |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +     +  +  +        +  +     +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Pheochromocytoma Benign              | X                                            X                    X      |             
      Bilateral, Pheochromocytoma Benign   |                X                                            X            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  81                                                               
NTP Experiment-Test: 05061-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 17:56:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 4| 5| 4| 7| 4| 4| 6| 2| 4| 7| 7| 6| 2| 7| 6| 5| 2| 2| 6| 4| 5| 4| 2|             
                             DAY ON TEST   | 0| 9| 5| 5| 9| 2| 5| 5| 7| 7| 5| 2| 2| 2| 7| 2| 1| 8| 7| 7| 3| 5| 9| 7| 7|             
                                           | 9| 6| 8| 3| 3| 9| 6| 8| 9| 4| 6| 9| 9| 4| 4| 1| 0| 1| 6| 6| 1| 8| 0| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    1.0%                                   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    71MHM                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +     +  +  +        +        +  +  +     +  +  +        +     +  +   |             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M     +  +  M        M  +     +  +  +  +  +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +     +  +  +        +  +     +  +  +  M  +  +  +  +  +  +     +  +  +|             
      Pars Distalis, Adenoma               |    X           X        X        X                                X      |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +     +  +  +        +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      C-Cell, Adenoma                      |                                     X                                    |             
      Follicular Cell, Adenoma             |                                                                          |             
      Follicular Cell, Carcinoma           |                X                                                         |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +     +  +  +        +  +     +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Mesothelioma Malignant               |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +     +  +  +        +  +     +  +  +  M  +  +  +  +  +  +     +  +  +|             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +     +  +  +        +  +     +  +  +  +  +  +  +  +  +  +     +  M  +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +     +  +  +        +  +     +  +  +  +  +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mesothelioma Malignant               |                                                                          |             
      Bilateral, Interstitial Cell, Adenoma| X  X     X     X        X        X  X  X     X  X  X        X     X  X   |             
      Interstitial Cell, Adenoma           | X     X           X  X                                         X         |             
      Tunic, Mesothelioma Malignant        |                   X                                                      |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +     +  +  +        +  +     +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Leukemia Mononuclear                 |                                                                   X      |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +                 +  +     +  +  +        M  +  +     M  M  +     +     M|             
      Pancreatic, Leukemia Mononuclear     |                                                                   X      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +     +  M  +     +  +  +     +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Leukemia Mononuclear                 |                                                                   X      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +     +  +  +  +     +  +     +  +  M  +  +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Leukemia Mononuclear                 |       X              X                                            X      |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  +     M  +  M        M  M     M  M  +  M  +  +  +  +  M  M     M  M  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +     +  +  +        +  +     +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Basal Cell Adenoma                   |                         X                                                |             
      Keratoacanthoma                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  82                                                               
NTP Experiment-Test: 05061-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 17:56:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 4| 5| 4| 7| 4| 4| 6| 2| 4| 7| 7| 6| 2| 7| 6| 5| 2| 2| 6| 4| 5| 4| 2|             
                             DAY ON TEST   | 0| 9| 5| 5| 9| 2| 5| 5| 7| 7| 5| 2| 2| 2| 7| 2| 1| 8| 7| 7| 3| 5| 9| 7| 7|             
                                           | 9| 6| 8| 3| 3| 9| 6| 8| 9| 4| 6| 9| 9| 4| 4| 1| 0| 1| 6| 6| 1| 8| 0| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    1.0%                                   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    71MHM                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Squamous Cell Papilloma              | X                                                                        |             
      Pinna, Squamous Cell Papilloma       |                                                                          |             
      Subcutaneous Tissue, Fibroma         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +     +  +  +        +  +     +  +  +  +  +  +  +  +  +  +     +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +     +  +  +        +  +     +  +  +  +  +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Alveolar/Bronchiolar Adenoma         |       X                                                                  |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |    X                             X           X     X        X            |             
      Leukemia Mononuclear                 |                                                                   X      |             
      Sarcoma, Metastatic, Kidney          |                                                                          |             
      Mediastinum, Alveolar/Bronchiolar    |                                                                          |             
          Carcinoma                        |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +     +  +  +        +  +     +  +  +  +  +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +     +  +  +        +  +     +  +  +  +  +  +  +  +  +  +     +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                         +                                                |             
                                            __________________________________________________________________________|             
   Eye                                     |    M           +                                                         |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                         +                                                |             
      Carcinoma                            |                                                                          |             
      Squamous Cell Carcinoma              |                         X                                                |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Renal Tubule, Adenoma                |                      X  X                                                |             
      Renal Tubule, Adenoma, Multiple      |                X                                                         |             
      Renal Tubule, Carcinoma              |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Transitional Epithelium, Carcinoma   |                                                                          |             
      Transitional Epithelium, Papilloma   |             X                                      X                     |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X              X                                            X      |             
      Mesothelioma Malignant               |                   X                                                      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  83                                                               
NTP Experiment-Test: 05061-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 17:56:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 4| 2| 4| 7| 5| 5| 5| 7| 5| 2| 2| 2| 7| 4| 7| 6| 4| 7| 5| 5| 4| 2|             
                             DAY ON TEST   | 2| 2| 2| 3| 8| 5| 1| 9| 7| 2| 2| 8| 7| 7| 7| 2| 5| 1| 8| 9| 2| 7| 4| 5| 7|             
                                           | 9| 9| 2| 5| 1| 8| 4| 1| 7| 7| 9| 8| 5| 4| 5| 4| 6| 5| 9| 7| 4| 3| 2| 8| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    1.0%                                   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    71MHM                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | M  +  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +|             
      Adenocarcinoma                       |                                                    X        X            |             
      Polyp Adenomatous, Multiple          |                                                             X            |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Adenocarcinoma                       | X                    X  X     X                    X                     |             
      Adenocarcinoma, Multiple             |                                                                          |             
      Polyp Adenomatous                    |                X        X  X     X                             X         |             
      Polyp Adenomatous, Multiple          | X  X  X           X  X        X              X     X  X     X            |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cholangiocarcinoma                   |                                                       X                  |             
      Hepatocellular Carcinoma             |                X     X     X                                   X  X      |             
      Hepatocellular Carcinoma, Multiple   | X  X  X           X     X     X  X           X  X  X  X  X  X        X   |             
      Hepatocellular Adenoma               |          X                                            X        X         |             
      Hepatocellular Adenoma, Multiple     | X     X           X     X     X  X           X  X  X        X            |             
      Hepatocholangiocarcinoma             | X                          X                                             |             
      Hepatocholangioma                    |       X                                                                  |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                     M  M  +                       +     M|             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +|             
      Adenocarcinoma, Metastatic,          |                                                                          |             
          Intestine Large, Rectum          |                                                                          |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Squamous Cell Carcinoma              |    X                                                                     |             
      Squamous Cell Papilloma              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +  +  +  M  +     +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +|             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +|             
      Pheochromocytoma Benign              |                                                                          |             
      Bilateral, Pheochromocytoma Benign   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  84                                                               
NTP Experiment-Test: 05061-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 17:56:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 4| 2| 4| 7| 5| 5| 5| 7| 5| 2| 2| 2| 7| 4| 7| 6| 4| 7| 5| 5| 4| 2|             
                             DAY ON TEST   | 2| 2| 2| 3| 8| 5| 1| 9| 7| 2| 2| 8| 7| 7| 7| 2| 5| 1| 8| 9| 2| 7| 4| 5| 7|             
                                           | 9| 9| 2| 5| 1| 8| 4| 1| 7| 7| 9| 8| 5| 4| 5| 4| 6| 5| 9| 7| 4| 3| 2| 8| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    1.0%                                   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    71MHM                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +     +  +  +  +  +  +           +     +  +  +  +  +  +      |             
      Adenoma                              | X                                                                        |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +     M  +  M  +  +  +  +  +  +  +     +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  M  +     +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +|             
      Pars Distalis, Adenoma               |    X                 X  X                                                |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +|             
      Adenoma                              |                                                                          |             
      C-Cell, Adenoma                      |                                                                          |             
      Follicular Cell, Adenoma             |                                                                          |             
      Follicular Cell, Carcinoma           |                         X                          X                     |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +|             
      Mesothelioma Malignant               |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | M  +  +  +  +     +  +  +  +  +  +  +  +  +  +     +  M  +  +  +  +     +|             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mesothelioma Malignant               |                                                                          |             
      Bilateral, Interstitial Cell, Adenoma| X  X              X  X     X  X  X                 X  X  X  X  X  X      |             
      Interstitial Cell, Adenoma           |                X                             X                           |             
      Tunic, Mesothelioma Malignant        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +  +           +  +  +           M  M  M  +     +                    +|             
      Pancreatic, Leukemia Mononuclear     |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  +  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  M  M  M  +  +  M  +  +  +  M  +  +  +  +  M  +  M  M  M  M  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  +  M  M     M  +  +  +  M  +  +  M  +  M     M  M  +  M  +  +     +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +|             
      Basal Cell Adenoma                   |                                                                          |             
      Keratoacanthoma                      |                            X                                             |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  85                                                               
NTP Experiment-Test: 05061-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 17:56:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 4| 2| 4| 7| 5| 5| 5| 7| 5| 2| 2| 2| 7| 4| 7| 6| 4| 7| 5| 5| 4| 2|             
                             DAY ON TEST   | 2| 2| 2| 3| 8| 5| 1| 9| 7| 2| 2| 8| 7| 7| 7| 2| 5| 1| 8| 9| 2| 7| 4| 5| 7|             
                                           | 9| 9| 2| 5| 1| 8| 4| 1| 7| 7| 9| 8| 5| 4| 5| 4| 6| 5| 9| 7| 4| 3| 2| 8| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    1.0%                                   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    71MHM                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Squamous Cell Papilloma              |                                                                          |             
      Pinna, Squamous Cell Papilloma       |                                                                          |             
      Subcutaneous Tissue, Fibroma         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Spinal Cord                             |          +  +        +                                                   |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +  +  +  M  +     +|             
      Alveolar/Bronchiolar Adenoma         |                            X  X                                          |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           | X     X           X        X                       X                     |             
      Leukemia Mononuclear                 |                                                                          |             
      Sarcoma, Metastatic, Kidney          |                                                          X               |             
      Mediastinum, Alveolar/Bronchiolar    |                                                                          |             
          Carcinoma                        |          X                                                               |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                             +            |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |          +                                                               |             
      Carcinoma                            |          X                                                               |             
      Squamous Cell Carcinoma              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Renal Tubule, Adenoma                |                   X           X  X                                   X   |             
      Renal Tubule, Adenoma, Multiple      | X  X  X                                      X                           |             
      Renal Tubule, Carcinoma              |                                                          X               |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Transitional Epithelium, Carcinoma   | X                 X                                                      |             
      Transitional Epithelium, Papilloma   |                               X              X     X     X               |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Mesothelioma Malignant               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  86                                                               
NTP Experiment-Test: 05061-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 17:56:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 4| 3| 6| 5| 4| 3| 2| 7| 7| 7| 6| 6| 7| 6| 6| 6| 4|              |            |
                             DAY ON TEST   | 2| 0| 2| 3| 5| 4| 5| 5| 6| 7| 2| 2| 0| 7| 0| 2| 7| 7| 3| 5|              |            |
                                           | 9| 3| 5| 6| 2| 6| 2| 6| 4| 5| 9| 9| 2| 4| 5| 9| 4| 1| 1| 6|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|              |     A      |
    1.0%                                   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|              |     L      |
    71MHM                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +                  |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +               |  61        |
      Adenocarcinoma                       |       X                                                                  |          4 |
      Polyp Adenomatous, Multiple          |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  69        |
      Adenocarcinoma                       |    X  X                       X  X              X  X                     |         12 |
      Adenocarcinoma, Multiple             |                                                                          |          3 |
      Polyp Adenomatous                    |             X     X                       X     X        X               |         16 |
      Polyp Adenomatous, Multiple          | X  X  X        X              X  X  X  X     X     X  X                  |         30 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +                  |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +                  |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +                  |  58        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +                  |  59        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Cholangiocarcinoma                   |                                                                          |          1 |
      Hepatocellular Carcinoma             |          X                                               X               |         13 |
      Hepatocellular Carcinoma, Multiple   | X  X  X        X  X           X  X  X  X  X  X  X  X  X                  |         40 |
      Hepatocellular Adenoma               |    X           X     X        X                 X                        |         12 |
      Hepatocellular Adenoma, Multiple     | X                 X              X     X  X  X     X  X                  |         26 |
      Hepatocholangiocarcinoma             |                                                                          |          2 |
      Hepatocholangioma                    |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                            M  +                                          |   5        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +                  |  60        |
      Adenocarcinoma, Metastatic,          |                                                                          |            |
          Intestine Large, Rectum          |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pharynx                                 |                                           +                              |   1        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  M  +                  |  59        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  69        |
      Squamous Cell Carcinoma              |                                                                          |          1 |
      Squamous Cell Papilloma              |                                     X                                    |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
                                            __________________________________________________________________________|____________|
   Tongue                                  |                +                                                         |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +                  |  59        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +                  |  60        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  87                                                               
NTP Experiment-Test: 05061-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 17:56:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 4| 3| 6| 5| 4| 3| 2| 7| 7| 7| 6| 6| 7| 6| 6| 6| 4|              |            |
                             DAY ON TEST   | 2| 0| 2| 3| 5| 4| 5| 5| 6| 7| 2| 2| 0| 7| 0| 2| 7| 7| 3| 5|              |            |
                                           | 9| 3| 5| 6| 2| 6| 2| 6| 4| 5| 9| 9| 2| 4| 5| 9| 4| 1| 1| 6|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|              |     A      |
    1.0%                                   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|              |     L      |
    71MHM                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +                  |  60        |
      Pheochromocytoma Benign              |                                     X        X                           |          5 |
      Bilateral, Pheochromocytoma Benign   |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +     +     +  +  +  +  +  +  +  +  +                  |  50        |
      Adenoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  M     +  +  +  +  +  +  +  +  +  +  +                  |  54        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +                  |  58        |
      Pars Distalis, Adenoma               |                               X           X                              |         10 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +                  |  61        |
      Adenoma                              |       X                                                                  |          1 |
      C-Cell, Adenoma                      | X                                                  X                     |          3 |
      Follicular Cell, Adenoma             |                                              X                           |          1 |
      Follicular Cell, Carcinoma           |                                                                          |          3 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +                  |  60        |
      Mesothelioma Malignant               |          X                                                               |          1 |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  M                  |  56        |
      Adenoma                              |                   X                                                      |          1 |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +                  |  59        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +                  |  60        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                  |  68        |
      Mesothelioma Malignant               |          X                                                               |          1 |
      Bilateral, Interstitial Cell, Adenoma| X  X  X        X  X              X     X  X  X     X  X                  |         38 |
      Interstitial Cell, Adenoma           |                               X     X           X                        |         10 |
      Tunic, Mesothelioma Malignant        |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +                  |  60        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +     +                    M  +  +  +           +  +                     |  25        |
      Pancreatic, Leukemia Mononuclear     |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +                  |  59        |
      Leukemia Mononuclear                 |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  88                                                               
NTP Experiment-Test: 05061-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 17:56:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 4| 3| 6| 5| 4| 3| 2| 7| 7| 7| 6| 6| 7| 6| 6| 6| 4|              |            |
                             DAY ON TEST   | 2| 0| 2| 3| 5| 4| 5| 5| 6| 7| 2| 2| 0| 7| 0| 2| 7| 7| 3| 5|              |            |
                                           | 9| 3| 5| 6| 2| 6| 2| 6| 4| 5| 9| 9| 2| 4| 5| 9| 4| 1| 1| 6|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|              |     A      |
    1.0%                                   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|              |     L      |
    71MHM                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +                  |  60        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +                  |  62        |
      Leukemia Mononuclear                 |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  M  M  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  M  +               |  53        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  M  M  +  +  +     M  M  +  +  +  +  +  M  M  M  M                  |  29        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +                  |  60        |
      Basal Cell Adenoma                   |                                                                          |          1 |
      Keratoacanthoma                      |                                                                          |          1 |
      Squamous Cell Papilloma              |                                                                          |          1 |
      Pinna, Squamous Cell Papilloma       |                                                 X                        |          1 |
      Subcutaneous Tissue, Fibroma         |                                                       X                  |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +                  |  60        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +                  |  60        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             | +                                                                        |   4        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                  |  62        |
      Alveolar/Bronchiolar Adenoma         |                                                       X                  |          4 |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |       X  X        X           X     X     X     X  X  X                  |         19 |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Sarcoma, Metastatic, Kidney          |                                                                          |          1 |
      Mediastinum, Alveolar/Bronchiolar    |                                                                          |            |
          Carcinoma                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +                  |  60        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +                  |  60        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Eye                                     | +  +                          +                 +                        |   6        |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   2        |
      Carcinoma                            |                                                                          |          1 |
      Squamous Cell Carcinoma              |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  89                                                               
NTP Experiment-Test: 05061-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 17:56:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 4| 3| 6| 5| 4| 3| 2| 7| 7| 7| 6| 6| 7| 6| 6| 6| 4|              |            |
                             DAY ON TEST   | 2| 0| 2| 3| 5| 4| 5| 5| 6| 7| 2| 2| 0| 7| 0| 2| 7| 7| 3| 5|              |            |
                                           | 9| 3| 5| 6| 2| 6| 2| 6| 4| 5| 9| 9| 2| 4| 5| 9| 4| 1| 1| 6|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|              |     A      |
    1.0%                                   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|              |     L      |
    71MHM                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Renal Tubule, Adenoma                | X              X                    X           X     X                  |         11 |
      Renal Tubule, Adenoma, Multiple      |                                                                          |          5 |
      Renal Tubule, Carcinoma              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Transitional Epithelium, Carcinoma   |    X                                   X                                 |          4 |
      Transitional Epithelium, Papilloma   |                               X     X                                    |          8 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Leukemia Mononuclear                 |                                                                          |          3 |
      Mesothelioma Malignant               |          X                                                               |          2 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  90                                                               
NTP Experiment-Test: 05061-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 17:56:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 2| 2| 4| 4| 4| 2| 2| 4| 4| 4| 2| 2| 4| 4| 4| 2| 2|             
                             DAY ON TEST   | 5| 5| 2| 5| 5| 5| 5| 5| 7| 7| 5| 5| 5| 7| 7| 5| 5| 2| 7| 7| 5| 5| 0| 7| 7|             
                                           | 6| 7| 7| 6| 8| 7| 7| 7| 4| 5| 8| 6| 6| 5| 4| 7| 6| 3| 4| 4| 8| 6| 0| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    2.0%                                   | 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    71HM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Polyp Adenomatous                    |                                                                         X|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma                       |       X     X                                                            |             
      Polyp Adenomatous                    |          X     X  X                             X           X            |             
      Polyp Adenomatous, Multiple          |                                                                X         |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  A  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Carcinoma             |             X              X     X  X  X     X                 X         |             
      Hepatocellular Carcinoma, Multiple   |    X  X  X     X  X  X        X                 X  X        X     X      |             
      Hepatocellular Adenoma               |                                           X        X  X        X         |             
      Hepatocellular Adenoma, Multiple     | X                                            X              X            |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                   +      |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Squamous Cell Papilloma              |                      X                                                   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |       +                                            +              +      |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               |    X                                                                     |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Adenoma             |                            X                                             |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mesothelioma Malignant               |                                                                   X      |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Carcinoma                            |                                                                X         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  91                                                               
NTP Experiment-Test: 05061-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 17:56:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 2| 2| 4| 4| 4| 2| 2| 4| 4| 4| 2| 2| 4| 4| 4| 2| 2|             
                             DAY ON TEST   | 5| 5| 2| 5| 5| 5| 5| 5| 7| 7| 5| 5| 5| 7| 7| 5| 5| 2| 7| 7| 5| 5| 0| 7| 7|             
                                           | 6| 7| 7| 6| 8| 7| 7| 7| 4| 5| 8| 6| 6| 5| 4| 7| 6| 3| 4| 4| 8| 6| 0| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    2.0%                                   | 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    71HM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mesothelioma Malignant               |                                                                   X      |             
      Interstitial Cell, Adenoma           |                X                                               X         |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |       +     +           M  M     +     M  M           M  +           M  +|             
      Mediastinal, Hepatocellular          |                                                                          |             
          Carcinoma, Metastatic, Liver     |       X                                                                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  M  +  M  +  +  +  M  M  M  M  +  M  +  +  M  +  M  +  +  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                                       X                  |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |       X        X     X        X                    X              X      |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                         M  M           M  M     +     M  M           M  M|             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                         M  M           M  M           M  M           M  M|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                    X                     |             
      Renal Tubule, Adenoma                |                   X  X                                                   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  92                                                               
NTP Experiment-Test: 05061-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 17:56:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 2| 2| 4| 4| 4| 2| 2| 4| 4| 4| 2| 2| 4| 4| 4| 2| 2|             
                             DAY ON TEST   | 5| 5| 2| 5| 5| 5| 5| 5| 7| 7| 5| 5| 5| 7| 7| 5| 5| 2| 7| 7| 5| 5| 0| 7| 7|             
                                           | 6| 7| 7| 6| 8| 7| 7| 7| 4| 5| 8| 6| 6| 5| 4| 7| 6| 3| 4| 4| 8| 6| 0| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    2.0%                                   | 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    71HM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Papilloma                            |                               X                          X               |             
      Squamous Cell Carcinoma              |                                              X                           |             
      Transitional Epithelium, Carcinoma   |                                                             X            |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mesothelioma Malignant               |                                                                   X      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  93                                                               
NTP Experiment-Test: 05061-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 17:56:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 2| 2|                                                           |            |
                             DAY ON TEST   | 5| 5| 5| 7| 7|                                                           |            |
                                           | 7| 8| 7| 5| 3|                                                           |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0|                                                           |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0|                                                           |     T      |
                               ANIMAL ID   | 6| 6| 6| 6| 6|                                                           |     A      |
    2.0%                                   | 0| 0| 0| 0| 0|                                                           |     L      |
    71HM                                   | 1| 2| 3| 4| 5|                                                           |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +                                                            |  30        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +                                                            |  30        |
      Polyp Adenomatous                    |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +                                                            |  30        |
      Adenocarcinoma                       |                                                                          |          2 |
      Polyp Adenomatous                    |    X                                                                     |          6 |
      Polyp Adenomatous, Multiple          |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +                                                            |  28        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +                                                            |  29        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +                                                            |  29        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +                                                            |  29        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +                                                            |  30        |
      Hepatocellular Carcinoma             |       X                                                                  |          8 |
      Hepatocellular Carcinoma, Multiple   | X  X                                                                     |         13 |
      Hepatocellular Adenoma               |       X                                                                  |          5 |
      Hepatocellular Adenoma, Multiple     | X  X                                                                     |          5 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +                                                            |  30        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +                                                            |  29        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +                                                            |  30        |
      Squamous Cell Papilloma              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +                                                            |  30        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +                                                            |  30        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +                                                            |  30        |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +                                                            |  30        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |                                                                          |   3        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +                                                            |  30        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | M  +  +  +  +                                                            |  29        |
      Pars Distalis, Adenoma               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +                                                            |  30        |
      Follicular Cell, Adenoma             |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  94                                                               
NTP Experiment-Test: 05061-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 17:56:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 2| 2|                                                           |            |
                             DAY ON TEST   | 5| 5| 5| 7| 7|                                                           |            |
                                           | 7| 8| 7| 5| 3|                                                           |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0|                                                           |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0|                                                           |     T      |
                               ANIMAL ID   | 6| 6| 6| 6| 6|                                                           |     A      |
    2.0%                                   | 0| 0| 0| 0| 0|                                                           |     L      |
    71HM                                   | 1| 2| 3| 4| 5|                                                           |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +                                                            |  30        |
      Mesothelioma Malignant               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +                                                            |  29        |
      Carcinoma                            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +                                                            |  30        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +                                                            |  30        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +                                                            |  30        |
      Mesothelioma Malignant               |                                                                          |          1 |
      Interstitial Cell, Adenoma           |    X                                                                     |          3 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +                                                            |  30        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |          M  +                                                            |   6        |
      Mediastinal, Hepatocellular          |                                                                          |            |
          Carcinoma, Metastatic, Liver     |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +                                                            |  27        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +                                                            |  30        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +                                                            |  30        |
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  +  +  +  +                                                            |  26        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  +  M                                                            |  15        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  M  +  +                                                            |  29        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +                                                            |  30        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +                                                            |  30        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +                                                            |  30        |
      Alveolar/Bronchiolar Adenoma         |                                                                          |          1 |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |    X                                                                     |          7 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +                                                            |  30        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +                                                            |  30        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  95                                                               
NTP Experiment-Test: 05061-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 17:56:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 2| 2|                                                           |            |
                             DAY ON TEST   | 5| 5| 5| 7| 7|                                                           |            |
                                           | 7| 8| 7| 5| 3|                                                           |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0|                                                           |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0|                                                           |     T      |
                               ANIMAL ID   | 6| 6| 6| 6| 6|                                                           |     A      |
    2.0%                                   | 0| 0| 0| 0| 0|                                                           |     L      |
    71HM                                   | 1| 2| 3| 4| 5|                                                           |            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |          M  M                                                            |   1        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |          M  M                                                            |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +                                                            |  30        |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |                                                                          |          1 |
      Renal Tubule, Adenoma                |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  M  +                                                            |  28        |
      Papilloma                            | X     X                                                                  |          4 |
      Squamous Cell Carcinoma              |                                                                          |          1 |
      Transitional Epithelium, Carcinoma   |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +                                                            |  30        |
      Mesothelioma Malignant               |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  96                                                               
NTP Experiment-Test: 05061-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 17:56:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 4| 5| 5| 5| 4| 1|                                            |            |
                                           | 8| 8| 6| 8| 7| 6| 8| 8| 2| 4|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |     A      |
    2.0%                                   | 4| 4| 4| 4| 4| 7| 7| 7| 7| 7|                                            |     L      |
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Polyp Adenomatous                    |                X           X                                             |          2 |
      Polyp Adenomatous, Multiple          |                      X                                                   |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  M  +                                             |   9        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Hepatocellular Carcinoma             | X  X           X  X                                                      |          4 |
      Hepatocellular Carcinoma, Multiple   |       X     X           X                                                |          3 |
      Hepatocellular Adenoma               | X  X  X           X  X  X  X                                             |          7 |
      Hepatocholangiocarcinoma             |                            X                                             |          1 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                         +                                                |   1        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Hepatocholangiocarcinoma, Metastatic,|                                                                          |            |
           Liver                           |                            X                                             |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |             +           +  +                                             |   3        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  97                                                               
NTP Experiment-Test: 05061-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 17:56:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 4| 5| 5| 5| 4| 1|                                            |            |
                                           | 8| 8| 6| 8| 7| 6| 8| 8| 2| 4|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |     A      |
    2.0%                                   | 4| 4| 4| 4| 4| 7| 7| 7| 7| 7|                                            |     L      |
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Bilateral, Interstitial Cell, Adenoma|             X                                                            |          1 |
      Interstitial Cell, Adenoma           | X        X           X                                                   |          3 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |       +                 +                                                |   2        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  +  +  +  +  +  +  +  M  +                                             |   8        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  M                                             |   9        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  M  +  +  +  +  +  +  +                                             |   9        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  +  +  +  M  +  +  +  +                                             |   7        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |    X  X     X     X     X                                                |          5 |
      Hepatocholangiocarcinoma, Metastatic,|                                                                          |            |
           Liver                           |                            X                                             |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Renal Tubule, Adenoma                |    X              X  X                                                   |          3 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  98                                                               
NTP Experiment-Test: 05061-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 17:56:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 4| 5| 5| 5| 4| 1|                                            |            |
                                           | 8| 8| 6| 8| 7| 6| 8| 8| 2| 4|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |     A      |
    2.0%                                   | 4| 4| 4| 4| 4| 7| 7| 7| 7| 7|                                            |     L      |
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  99                                                               
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                                  ----------              END OF REPORT             ----------                                      
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