National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/1736

TR 383 Mouse Pathology Tables


                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE


NTP Experiment-Test: 05061-02                                                                                     Report: PEIRPT03
Study Type: CHRONIC                                                                                               Date: 05/19/95
Route: DOSED FEED                                                                                                 Time: 16:49:58




       Facility:  TSI Mason Research

       Chemical CAS #:  81-49-2

       Lock Date:  03/25/92

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05061-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 05/19/95  
Route: DOSED FEED                                                                                                 Time: 16:49:58  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        UNTREATE     1.0%         2.0%                                                   
                                                   D 71UF       71LF         71HF                                                   
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          60           60           60                                                  
  Scheduled Sacrifice                                 10           10           10                                                  
  Early Deaths                                                                                                                      
    Moribund                                           5           11           11                                                  
    Dead                                               6            5            6                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                38           33           33                                                  
    Moribund                                           1                                                                            
    Dead                                                            1                                                               
  Animals Examined Microscopically                    60           60           60                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (60)         (55)         (57)                                                
      Autolysis                                                                  1 (2%)                                             
   Gallbladder                                        (59)         (57)         (54)                                                
      Autolysis                                        3 (5%)       2 (4%)       2 (4%)                                             
      Inflammation, Chronic                            1 (2%)                    1 (2%)                                             
      Inflammation, Chronic Active                     6 (10%)      6 (11%)      8 (15%)                                            
      Epithelium, Hyperplasia                                       1 (2%)                                                          
   Intestine Large, Colon                             (60)         (60)         (58)                                                
      Autolysis                                        3 (5%)       1 (2%)                                                          
      Inflammation, Acute                                           1 (2%)                                                          
      Peyer's Patch, Hyperplasia                                    1 (2%)       1 (2%)                                             
   Intestine Large, Rectum                            (60)         (60)         (57)                                                
      Autolysis                                        2 (3%)       1 (2%)                                                          
      Peyer's Patch, Epithelium, Proliferation         1 (2%)                                                                       
   Intestine Large, Cecum                             (60)         (59)         (57)                                                
      Autolysis                                        4 (7%)       1 (2%)                                                          
      Peyer's Patch, Hyperplasia                       1 (2%)       2 (3%)                                                          
   Intestine Small, Duodenum                          (58)         (60)         (56)                                                
      Angiectasis                                                   1 (2%)                                                          
      Autolysis                                        2 (3%)       2 (3%)       2 (4%)                                             
   Intestine Small, Jejunum                           (57)         (60)         (56)                                                
      Autolysis                                        1 (2%)       2 (3%)       2 (4%)                                             
      Peyer's Patch, Hyperplasia                                                 2 (4%)                                             
   Intestine Small, Ileum                             (58)         (60)         (56)                                                
      Autolysis                                        2 (3%)       2 (3%)       2 (4%)                                             
      Inflammation, Acute                                           1 (2%)                                                          
      Peyer's Patch, Hyperplasia                       4 (7%)       3 (5%)       1 (2%)                                             
      Peyer's Patch, Inflammation, Acute                                         1 (2%)                                             
   Liver                                              (60)         (60)         (60)                                                
      Autolysis                                        2 (3%)                    1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05061-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 05/19/95  
Route: DOSED FEED                                                                                                 Time: 16:49:58  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        UNTREATE     1.0%         2.0%                                                   
                                                   D 71UF       71LF         71HF                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Basophilic Focus                                              5 (8%)       6 (10%)                                            
      Clear Cell Focus                                             10 (17%)      9 (15%)                                            
      Eosinophilic Focus                                            4 (7%)       2 (3%)                                             
      Fatty Change                                     3 (5%)       4 (7%)      18 (30%)                                            
      Fibrosis                                                                   1 (2%)                                             
      Hematopoietic Cell Proliferation                 3 (5%)       6 (10%)      6 (10%)                                            
      Hemorrhage                                                                 1 (2%)                                             
      Inflammation, Acute                                           5 (8%)       4 (7%)                                             
      Inflammation, Chronic Active                    36 (60%)     28 (47%)     29 (48%)                                            
      Mixed Cell Focus                                              2 (3%)                                                          
      Necrosis, Coagulative                           16 (27%)     26 (43%)     25 (42%)                                            
      Pigmentation                                                 54 (90%)     58 (97%)                                            
      Bile Duct, Hyperplasia                                        1 (2%)                                                          
      Bile Duct, Hyperplasia, Focal                                 1 (2%)                                                          
   Mesentery                                          (6)          (9)          (8)                                                 
      Fibrosis                                                      4 (44%)                                                         
      Inflammation, Chronic Active                     3 (50%)      5 (56%)      4 (50%)                                            
      Mineralization                                   1 (17%)                                                                      
      Necrosis, Coagulative                            1 (17%)      3 (33%)                                                         
      Pigmentation                                     1 (17%)                                                                      
   Pancreas                                           (60)         (60)         (59)                                                
      Atrophy                                                       1 (2%)       2 (3%)                                             
      Autolysis                                                                  2 (3%)                                             
      Cytoplasmic Alteration                           3 (5%)       1 (2%)                                                          
      Fibrosis                                                                   1 (2%)                                             
      Inflammation                                                  1 (2%)                                                          
      Inflammation, Chronic                            5 (8%)                    1 (2%)                                             
      Inflammation, Chronic Active                    25 (42%)     24 (40%)     18 (31%)                                            
      Vacuolization Cytoplasmic                       20 (33%)     13 (22%)     21 (36%)                                            
      Duct, Dilatation                                 1 (2%)       1 (2%)       1 (2%)                                             
      Duct, Hyperplasia                                             1 (2%)                                                          
   Salivary Glands                                    (59)         (60)         (57)                                                
      Inflammation, Chronic                                         1 (2%)       5 (9%)                                             
      Parotid Gland, Autolysis                                                   1 (2%)                                             
      Sublingual Gland, Inflammation, Chronic          1 (2%)       2 (3%)                                                          
      Submandibular Gland, Autolysis                                             1 (2%)                                             
      Submandibular Gland, Inflammation, Chronic      47 (80%)     32 (53%)     33 (58%)                                            
   Stomach, Forestomach                               (58)         (60)         (60)                                                
      Acanthosis                                       9 (16%)     16 (27%)     27 (45%)                                            
      Autolysis                                                                  1 (2%)                                             
      Erosion                                                       1 (2%)       1 (2%)                                             
      Hyperkeratosis                                  10 (17%)     16 (27%)     24 (40%)                                            
      Hyperplasia, Basal Cell                                       7 (12%)      5 (8%)                                             
      Hyperplasia, Squamous                                                      2 (3%)                                             
      Inflammation, Chronic                                                      2 (3%)                                             
      Inflammation, Chronic Active                     7 (12%)     11 (18%)     24 (40%)                                            
      Ulcer                                            2 (3%)       1 (2%)       2 (3%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05061-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 05/19/95  
Route: DOSED FEED                                                                                                 Time: 16:49:58  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        UNTREATE     1.0%         2.0%                                                   
                                                   D 71UF       71LF         71HF                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Ulcer, Multiple                                  1 (2%)                                                                       
   Stomach, Glandular                                 (59)         (58)         (58)                                                
      Autolysis                                        2 (3%)                    1 (2%)                                             
      Inflammation, Chronic                            2 (3%)       1 (2%)       1 (2%)                                             
      Inflammation, Chronic Active                    21 (36%)     19 (33%)     21 (36%)                                            
      Mineralization                                   1 (2%)                    1 (2%)                                             
   Tooth                                              (1)                                                                           
      Abscess                                          1 (100%)                                                                     
      Dysplasia                                        1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (60)         (60)         (59)                                                
      Autolysis                                                                  1 (2%)                                             
      Cardiomyopathy                                   2 (3%)                                                                       
      Inflammation, Chronic                            9 (15%)      6 (10%)      8 (14%)                                            
      Mineralization                                                1 (2%)       1 (2%)                                             
      Thrombosis                                                    1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (60)         (59)         (58)                                                
      Angiectasis                                      2 (3%)                                                                       
      Autolysis                                                                  1 (2%)                                             
      Cyst                                                          1 (2%)                                                          
      Degeneration, Fatty                                                        1 (2%)                                             
      Hematopoietic Cell Proliferation                 1 (2%)       3 (5%)       1 (2%)                                             
      Hyperplasia                                                   1 (2%)       1 (2%)                                             
      Inflammation, Chronic Active                     2 (3%)       1 (2%)                                                          
      Vacuolization Cytoplasmic                                     1 (2%)                                                          
   Adrenal Medulla                                    (59)         (59)         (58)                                                
      Autolysis                                                                  1 (2%)                                             
      Hematopoietic Cell Proliferation                              1 (2%)       1 (2%)                                             
      Hyperplasia                                                   1 (2%)                                                          
   Islets, Pancreatic                                 (49)         (50)         (48)                                                
      Hyperplasia                                      3 (6%)       1 (2%)       1 (2%)                                             
   Parathyroid Gland                                  (43)         (49)         (43)                                                
      Cyst                                             1 (2%)                                                                       
   Pituitary Gland                                    (51)         (55)         (52)                                                
      Autolysis                                                                  1 (2%)                                             
      Pars Distalis, Angiectasis                       1 (2%)                                                                       
      Pars Distalis, Cyst                              3 (6%)                    1 (2%)                                             
      Pars Distalis, Hyperplasia                       8 (16%)     22 (40%)      8 (15%)                                            
      Pars Distalis, Pigmentation                      1 (2%)                                                                       
   Thyroid Gland                                      (60)         (60)         (58)                                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05061-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 05/19/95  
Route: DOSED FEED                                                                                                 Time: 16:49:58  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        UNTREATE     1.0%         2.0%                                                   
                                                   D 71UF       71LF         71HF                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Autolysis                                                                  1 (2%)                                             
      Inflammation, Chronic Active                     1 (2%)       2 (3%)       3 (5%)                                             
      C-Cell, Hyperplasia                              1 (2%)       1 (2%)       1 (2%)                                             
      Follicle, Cyst                                   2 (3%)                    2 (3%)                                             
      Follicular Cell, Hyperplasia                     3 (5%)      19 (32%)     18 (31%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                                               (1)                                                 
      Duct, Dilatation                                                           1 (100%)                                           
   Ovary                                              (59)         (51)         (57)                                                
      Abscess                                                       3 (6%)       2 (4%)                                             
      Angiectasis                                      2 (3%)       4 (8%)       4 (7%)                                             
      Cyst                                            13 (22%)     12 (24%)      9 (16%)                                            
      Cyst, Multiple                                   1 (2%)       3 (6%)       1 (2%)                                             
      Hemorrhage                                                    1 (2%)                                                          
      Inflammation, Acute, Necrotizing                 1 (2%)                                                                       
      Mineralization                                                2 (4%)                                                          
      Pigmentation                                     1 (2%)                                                                       
      Periovarian Tissue, Cyst                         1 (2%)       2 (4%)                                                          
      Periovarian Tissue, Cyst, Multiple                                         1 (2%)                                             
      Periovarian Tissue, Hemorrhage                                             1 (2%)                                             
      Periovarian Tissue, Inflammation, Chronic        2 (3%)                                                                       
      Periovarian Tissue, Inflammation, Chronic                                                                                     
          Active                                      29 (49%)     24 (47%)     28 (49%)                                            
      Periovarian Tissue, Mineralization               1 (2%)                                                                       
      Periovarian Tissue, Pigmentation                                           1 (2%)                                             
   Uterus                                             (59)         (60)         (59)                                                
      Angiectasis                                                                1 (2%)                                             
      Fibrosis                                                      2 (3%)       1 (2%)                                             
      Hydrometra                                      22 (37%)      3 (5%)       3 (5%)                                             
      Inflammation, Acute                                           1 (2%)                                                          
      Inflammation, Chronic Active                     4 (7%)       6 (10%)      7 (12%)                                            
      Endometrium, Hyperplasia                        44 (75%)     36 (60%)     45 (76%)                                            
      Epithelium, Metaplasia, Squamous                 2 (3%)       1 (2%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05061-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 05/19/95  
Route: DOSED FEED                                                                                                 Time: 16:49:58  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        UNTREATE     1.0%         2.0%                                                   
                                                   D 71UF       71LF         71HF                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (60)         (59)         (59)                                                
      Myelofibrosis                                    2 (3%)       5 (8%)       1 (2%)                                             
      Myeloid Cell, Sternal, Hyperplasia               2 (3%)       1 (2%)       2 (3%)                                             
      Sternal, Autolysis                                                         1 (2%)                                             
      Sternal, Myelofibrosis                          38 (63%)     32 (54%)     34 (58%)                                            
   Lymph Node                                         (7)          (12)         (12)                                                
      Lumbar, Hyperplasia, Lymphoid                    1 (14%)                   1 (8%)                                             
      Lumbar, Inflammation, Acute                      1 (14%)                                                                      
      Mediastinal, Hyperplasia, Lymphoid                                         1 (8%)                                             
      Mediastinal, Hyperplasia, Plasma Cell                                      1 (8%)                                             
      Mediastinal, Inflammation, Chronic Active        1 (14%)                                                                      
      Pancreatic, Hyperplasia, Lymphoid                             1 (8%)       1 (8%)                                             
      Pancreatic, Infiltration Cellular, Histiocyte                              1 (8%)                                             
      Pancreatic, Pigmentation                                                   1 (8%)                                             
      Renal, Hyperplasia, Plasma Cell                               2 (17%)                                                         
      Renal, Sinus, Ectasia                                                      1 (8%)                                             
   Lymph Node, Mandibular                             (38)         (55)         (41)                                                
      Autolysis                                                                  1 (2%)                                             
      Congestion                                       1 (3%)                                                                       
      Depletion Lymphoid                                            1 (2%)                                                          
      Hyperplasia, Lymphoid                            3 (8%)       1 (2%)       2 (5%)                                             
      Hyperplasia, Plasma Cell                         1 (3%)                    1 (2%)                                             
      Inflammation, Acute                                           1 (2%)                                                          
      Pigmentation                                     3 (8%)       2 (4%)       3 (7%)                                             
      Sinus, Ectasia                                                2 (4%)                                                          
   Lymph Node, Mesenteric                             (56)         (56)         (52)                                                
      Angiectasis                                      7 (13%)      4 (7%)       3 (6%)                                             
      Depletion Lymphoid                               2 (4%)       1 (2%)                                                          
      Hemorrhage                                                    2 (4%)                                                          
      Hyperplasia, Lymphoid                            2 (4%)       6 (11%)     10 (19%)                                            
      Infiltration Cellular, Histiocyte               36 (64%)     24 (43%)     34 (65%)                                            
      Inflammation, Chronic Active                     1 (2%)       3 (5%)       2 (4%)                                             
      Mineralization                                                1 (2%)                                                          
      Necrosis, Coagulative                            1 (2%)                                                                       
      Pigmentation                                    34 (61%)     24 (43%)     34 (65%)                                            
      Sinus, Ectasia                                                             1 (2%)                                             
   Spleen                                             (60)         (60)         (59)                                                
      Autolysis                                        1 (2%)                    1 (2%)                                             
      Depletion Lymphoid                               4 (7%)       2 (3%)       3 (5%)                                             
      Fibrosis                                         1 (2%)                                                                       
      Hematopoietic Cell Proliferation                 6 (10%)     13 (22%)     11 (19%)                                            
      Hyperplasia, Lymphoid                           15 (25%)     14 (23%)      8 (14%)                                            
      Inflammation, Chronic                            1 (2%)                                                                       
   Thymus                                             (49)         (48)         (42)                                                
      Angiectasis                                      1 (2%)                                                                       
      Cyst                                            20 (41%)     16 (33%)     28 (67%)                                            
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05061-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 05/19/95  
Route: DOSED FEED                                                                                                 Time: 16:49:58  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        UNTREATE     1.0%         2.0%                                                   
                                                   D 71UF       71LF         71HF                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Depletion Lymphoid                               4 (8%)       2 (4%)       6 (14%)                                            
      Hemorrhage                                                    1 (2%)       1 (2%)                                             
      Hyperplasia, Lymphoid                            3 (6%)       1 (2%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (35)         (35)         (30)                                                
      Hyperplasia                                      2 (6%)       9 (26%)      3 (10%)                                            
      Inflammation, Chronic                            1 (3%)                                                                       
   Skin                                               (60)         (60)         (60)                                                
      Acanthosis                                       1 (2%)                                                                       
      Autolysis                                                                  1 (2%)                                             
      Inflammation, Acute                              1 (2%)                                                                       
      Epidermis, Inflammation, Acute                                             1 (2%)                                             
      Subcutaneous Tissue, Cyst Epithelial                                                                                          
          Inclusion                                                 1 (2%)                                                          
      Subcutaneous Tissue, Fibrosis                                 1 (2%)                                                          
      Subcutaneous Tissue, Inflammation, Chronic                                                                                    
          Active                                       1 (2%)       2 (3%)       2 (3%)                                             
      Subcutaneous Tissue, Mineralization              1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (59)         (60)         (60)                                                
      Perivascular, Inflammation, Chronic                           1 (2%)                                                          
      Thalamus, Mineralization                        24 (41%)     15 (25%)     25 (42%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (60)         (59)                                                
      Autolysis                                                                  1 (2%)                                             
      Congestion                                       1 (2%)                                                                       
      Hemorrhage                                       4 (7%)       4 (7%)       8 (14%)                                            
      Infiltration Cellular, Histiocyte                                          1 (2%)                                             
      Inflammation, Chronic Active                     3 (5%)       4 (7%)       6 (10%)                                            
      Leukocytosis                                     1 (2%)       1 (2%)                                                          
      Alveolar Epithelium, Hyperplasia                                           1 (2%)                                             
      Pleura, Inflammation, Acute                                   1 (2%)                                                          
   Nose                                               (58)         (55)         (53)                                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 05061-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 05/19/95  
Route: DOSED FEED                                                                                                 Time: 16:49:58  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        UNTREATE     1.0%         2.0%                                                   
                                                   D 71UF       71LF         71HF                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Inflammation, Acute                             21 (36%)      9 (16%)      7 (13%)                                            
      Glands, Inflammation, Acute                      2 (3%)                    1 (2%)                                             
      Nasolacrimal Duct, Hyperplasia                   1 (2%)                                                                       
      Nasolacrimal Duct, Inflammation, Acute                        1 (2%)                                                          
   Trachea                                            (60)         (59)         (57)                                                
      Autolysis                                                                  1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (1)                       (1)                                                 
      Cornea, Inflammation, Chronic Active                                       1 (100%)                                           
      Cornea, Neovascularization                                                 1 (100%)                                           
   Harderian Gland                                    (1)          (3)          (2)                                                 
      Inflammation, Chronic                            1 (100%)                  2 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (54)         (60)                                                
      Autolysis                                                                  1 (2%)                                             
      Glomerulosclerosis                               2 (3%)       3 (6%)       4 (7%)                                             
      Hydronephrosis                                   1 (2%)       1 (2%)                                                          
      Infarct                                          1 (2%)                                                                       
      Inflammation, Chronic                           53 (88%)     46 (85%)     54 (90%)                                            
      Metaplasia, Osseous                                           3 (6%)       1 (2%)                                             
      Papilla, Mineralization                                                    1 (2%)                                             
      Pelvis, Transitional Epithelium, Hyperplasia                  1 (2%)                                                          
      Proximal Convoluted Renal Tubule,                                                                                             
          Degeneration, Hyaline                        1 (2%)                                                                       
      Renal Tubule, Atrophy                                         1 (2%)       3 (5%)                                             
      Renal Tubule, Casts Protein                      1 (2%)                                                                       
      Renal Tubule, Mineralization                                               3 (5%)                                             
      Renal Tubule, Pigmentation                                   43 (80%)     43 (72%)                                            
      Renal Tubule, Regeneration                       3 (5%)       7 (13%)      4 (7%)                                             
      Transitional Epithelium, Mineralization                                    1 (2%)                                             
   Urinary Bladder                                    (59)         (60)         (60)                                                
      Autolysis                                        3 (5%)       1 (2%)       2 (3%)                                             
      Inflammation, Chronic                            7 (12%)      7 (12%)      8 (13%)                                            
      Inflammation, Chronic Active                    42 (71%)     43 (72%)     46 (77%)                                            
      Arteriole, Necrosis, Fibrinoid                                             1 (2%)                                             
      Submucosa, Proliferation                         1 (2%)                                                                       
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
NTP Experiment-Test: 05061-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 05/19/95  
Route: DOSED FEED                                                                                                 Time: 16:49:58  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          UNTREATE     1.0%         2.0%                                                   
                                                   D 71UM       71LM         71HM                                                   
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          60           60           60                                                  
  Scheduled Sacrifice                                 10            9           10                                                  
  Early Deaths                                                                                                                      
    Moribund                                           7           23           21                                                  
    Dead                                               3            5            6                                                  
    Accident                                                        1                                                               
  Survivors                                                                                                                         
    Terminal Sacrifice                                40           22           23                                                  
  Animals Examined Microscopically                    60           60           60                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (56)         (56)         (51)                                                
      Autolysis                                        1 (2%)       2 (4%)                                                          
      Inflammation, Chronic                                                      1 (2%)                                             
      Inflammation, Chronic Active                    12 (21%)     12 (21%)      8 (16%)                                            
      Epithelium, Pigmentation                                      1 (2%)                                                          
   Intestine Large, Colon                             (60)         (58)         (60)                                                
      Autolysis                                        1 (2%)       2 (3%)                                                          
      Inflammation, Chronic Active                     1 (2%)       1 (2%)       2 (3%)                                             
      Peyer's Patch, Hyperplasia                       1 (2%)                                                                       
   Intestine Large, Rectum                            (58)         (58)         (58)                                                
      Autolysis                                        2 (3%)       2 (3%)                                                          
   Intestine Large, Cecum                             (59)         (60)         (60)                                                
      Autolysis                                        2 (3%)       2 (3%)                                                          
      Hemorrhage                                                    1 (2%)                                                          
      Hyperplasia, Lymphoid                                         1 (2%)                                                          
      Ulcer, Acute                                     1 (2%)                                                                       
      Epithelium, Hyperplasia                                       1 (2%)                                                          
      Peyer's Patch, Hyperplasia                       1 (2%)       1 (2%)                                                          
      Serosa, Inflammation, Chronic Active                          1 (2%)                                                          
   Intestine Small, Duodenum                          (60)         (59)         (56)                                                
      Autolysis                                        2 (3%)       1 (2%)                                                          
      Mesothelium, Hyperplasia                                                   1 (2%)                                             
      Peyer's Patch, Inflammation, Chronic,                                                                                         
          Granulomatous                                             1 (2%)                                                          
      Serosa, Fibrosis                                                           1 (2%)                                             
   Intestine Small, Jejunum                           (60)         (56)         (58)                                                
      Autolysis                                        2 (3%)       1 (2%)                                                          
      Hyperplasia, Lymphoid                                         1 (2%)                                                          
      Inflammation, Acute                                           1 (2%)                                                          
      Epithelium, Pigmentation                                                   1 (2%)                                             
      Peyer's Patch, Inflammation, Chronic,                                                                                         
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    9                                                              
NTP Experiment-Test: 05061-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 05/19/95  
Route: DOSED FEED                                                                                                 Time: 16:49:58  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          UNTREATE     1.0%         2.0%                                                   
                                                   D 71UM       71LM         71HM                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
          Granulomatous                                             1 (2%)                                                          
   Intestine Small, Ileum                             (60)         (58)         (57)                                                
      Autolysis                                        2 (3%)       1 (2%)                                                          
      Hyperplasia, Lymphoid                                         1 (2%)                                                          
      Inflammation, Acute, Necrotizing                 1 (2%)                                                                       
      Inflammation, Chronic Active                                               1 (2%)                                             
      Peyer's Patch, Hyperplasia                       1 (2%)       2 (3%)       1 (2%)                                             
      Peyer's Patch, Hyperplasia, Lymphoid             1 (2%)                                                                       
      Peyer's Patch, Inflammation, Chronic,                                                                                         
          Granulomatous                                             1 (2%)                                                          
   Liver                                              (60)         (60)         (60)                                                
      Angiectasis                                      1 (2%)                                                                       
      Basophilic Focus                                              4 (7%)       4 (7%)                                             
      Basophilic Focus, Focal                                                    1 (2%)                                             
      Clear Cell Focus                                 4 (7%)       4 (7%)       2 (3%)                                             
      Cytoplasmic Alteration                           1 (2%)                                                                       
      Eosinophilic Focus                                            6 (10%)      1 (2%)                                             
      Fatty Change                                    11 (18%)      6 (10%)      7 (12%)                                            
      Fibrosis                                                      1 (2%)                                                          
      Hematopoietic Cell Proliferation                 1 (2%)       5 (8%)      10 (17%)                                            
      Infarct                                                                    1 (2%)                                             
      Inflammation, Acute                              1 (2%)       9 (15%)      3 (5%)                                             
      Inflammation, Chronic Active                    15 (25%)     10 (17%)     27 (45%)                                            
      Karyomegaly                                                                1 (2%)                                             
      Mineralization                                   1 (2%)       1 (2%)                                                          
      Necrosis, Coagulative                            9 (15%)     20 (33%)     28 (47%)                                            
      Nuclear Alteration                                            1 (2%)                                                          
      Pigmentation                                     1 (2%)      59 (98%)     57 (95%)                                            
      Thrombosis                                                                 1 (2%)                                             
      Bile Duct, Hyperplasia                           1 (2%)       2 (3%)       1 (2%)                                             
      Centrilobular, Cytoplasmic Alteration                         9 (15%)      8 (13%)                                            
      Hepatocyte, Centrilobular, Hypertrophy                       17 (28%)     13 (22%)                                            
   Mesentery                                          (2)          (8)          (9)                                                 
      Abscess                                                                    1 (11%)                                            
      Fibrosis                                                                   1 (11%)                                            
      Inflammation, Chronic                                         1 (13%)                                                         
      Inflammation, Chronic Active                                  4 (50%)      5 (56%)                                            
      Mineralization                                                             1 (11%)                                            
      Necrosis, Coagulative                                         1 (13%)      2 (22%)                                            
      Thrombosis                                                    1 (13%)                                                         
   Pancreas                                           (60)         (59)         (58)                                                
      Atrophy                                          2 (3%)                    1 (2%)                                             
      Autolysis                                        1 (2%)       1 (2%)                                                          
      Cytoplasmic Alteration                           4 (7%)                    2 (3%)                                             
      Ectopic Liver                                                 1 (2%)                                                          
      Inflammation, Chronic                            2 (3%)                                                                       
      Inflammation, Chronic Active                    19 (32%)     12 (20%)      8 (14%)                                            
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   10                                                              
NTP Experiment-Test: 05061-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 05/19/95  
Route: DOSED FEED                                                                                                 Time: 16:49:58  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          UNTREATE     1.0%         2.0%                                                   
                                                   D 71UM       71LM         71HM                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Vacuolization Cytoplasmic                       20 (33%)     18 (31%)      4 (7%)                                             
      Acinus, Atrophy                                               1 (2%)                                                          
      Artery, Inflammation, Chronic Active                                       1 (2%)                                             
   Salivary Glands                                    (60)         (59)         (60)                                                
      Inflammation, Chronic                            2 (3%)                                                                       
      Duct, Parotid Gland, Mineralization                                        1 (2%)                                             
      Parotid Gland, Inflammation, Chronic             2 (3%)                                                                       
      Sublingual Gland, Inflammation, Chronic                       1 (2%)                                                          
      Sublingual Gland, Submandibular Gland,                                                                                        
          Inflammation, Chronic                                                  1 (2%)                                             
      Submandibular Gland, Atrophy                                               1 (2%)                                             
      Submandibular Gland, Inflammation, Chronic      45 (75%)     29 (49%)     40 (67%)                                            
   Stomach, Forestomach                               (59)         (59)         (60)                                                
      Abscess                                                       1 (2%)                                                          
      Acanthosis                                       1 (2%)      11 (19%)      7 (12%)                                            
      Autolysis                                        1 (2%)                                                                       
      Cyst                                                          1 (2%)                                                          
      Diverticulum                                                  1 (2%)                                                          
      Edema                                            1 (2%)                                                                       
      Erosion                                          1 (2%)                                                                       
      Hyperkeratosis                                   2 (3%)       9 (15%)      9 (15%)                                            
      Hyperplasia, Basal Cell                                       1 (2%)       3 (5%)                                             
      Inflammation, Acute                                                        1 (2%)                                             
      Inflammation, Chronic Active                     2 (3%)       6 (10%)     14 (23%)                                            
      Inflammation, Chronic Active, Necrotizing                                  1 (2%)                                             
      Ulcer                                                         2 (3%)                                                          
   Stomach, Glandular                                 (59)         (59)         (59)                                                
      Autolysis                                        1 (2%)                                                                       
      Edema                                                                      1 (2%)                                             
      Infiltration Cellular, Mast Cell                              1 (2%)                                                          
      Inflammation, Chronic                            1 (2%)       5 (8%)       2 (3%)                                             
      Inflammation, Chronic Active                    15 (25%)     24 (41%)     23 (39%)                                            
      Mineralization                                   4 (7%)                    3 (5%)                                             
      Muscularis, Mineralization                                    1 (2%)                                                          
   Tooth                                              (4)                       (7)                                                 
      Dysplasia                                        4 (100%)                  6 (86%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (60)         (60)         (60)                                                
      Cardiomyopathy                                   3 (5%)                    1 (2%)                                             
      Inflammation, Chronic                            7 (12%)     17 (28%)      5 (8%)                                             
      Mineralization                                   1 (2%)                                                                       
      Necrosis, Coagulative                                         1 (2%)                                                          
      Coronary Artery, Thrombosis                                   1 (2%)                                                          
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   11                                                              
NTP Experiment-Test: 05061-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 05/19/95  
Route: DOSED FEED                                                                                                 Time: 16:49:58  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          UNTREATE     1.0%         2.0%                                                   
                                                   D 71UM       71LM         71HM                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (60)         (60)         (60)                                                
      Hematopoietic Cell Proliferation                              1 (2%)                                                          
      Hyperplasia                                                   3 (5%)       2 (3%)                                             
      Inflammation, Chronic Active                     3 (5%)                                                                       
      Pigmentation                                     2 (3%)                                                                       
      Vacuolization Cytoplasmic                                                  1 (2%)                                             
      Capsule, Inflammation, Chronic Active                                      1 (2%)                                             
   Adrenal Medulla                                    (60)         (59)         (60)                                                
      Hyperplasia                                      1 (2%)       1 (2%)                                                          
      Inflammation, Acute                              1 (2%)                                                                       
      Pigmentation                                                  1 (2%)                                                          
   Islets, Pancreatic                                 (51)         (50)         (49)                                                
      Hyperplasia                                      9 (18%)      1 (2%)       1 (2%)                                             
      Inflammation, Chronic                                                      1 (2%)                                             
   Pituitary Gland                                    (52)         (54)         (56)                                                
      Pars Distalis, Cyst                              5 (10%)      4 (7%)       1 (2%)                                             
      Pars Distalis, Hyperplasia                      13 (25%)      9 (17%)      6 (11%)                                            
   Thyroid Gland                                      (59)         (59)         (59)                                                
      Inflammation, Chronic                            1 (2%)       1 (2%)       1 (2%)                                             
      Ultimobranchial Cyst                             1 (2%)       1 (2%)                                                          
      Follicle, Cyst                                                             1 (2%)                                             
      Follicular Cell, Hyperplasia                     2 (3%)       3 (5%)       3 (5%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Coagulating Gland                                  (1)          (1)          (1)                                                 
      Inflammation, Chronic Active                                               1 (100%)                                           
   Epididymis                                         (59)         (60)         (60)                                                
      Inflammation, Chronic Active                    30 (51%)     21 (35%)     26 (43%)                                            
      Epithelium, Hyperplasia                                       1 (2%)                                                          
      Serosa, Hyperplasia                                                        1 (2%)                                             
   Penis                                              (1)          (1)          (2)                                                 
      Hemorrhage                                                    1 (100%)                                                        
      Inflammation, Acute                              1 (100%)                                                                     
   Preputial Gland                                    (21)         (16)         (13)                                                
      Abscess                                          1 (5%)       3 (19%)      2 (15%)                                            
      Inflammation, Chronic                            2 (10%)                                                                      
      Inflammation, Chronic Active                    14 (67%)      7 (44%)     11 (85%)                                            
      Duct, Dilatation                                12 (57%)     10 (63%)      2 (15%)                                            
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   12                                                              
NTP Experiment-Test: 05061-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 05/19/95  
Route: DOSED FEED                                                                                                 Time: 16:49:58  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          UNTREATE     1.0%         2.0%                                                   
                                                   D 71UM       71LM         71HM                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
   Prostate                                           (57)         (55)         (57)                                                
      Inflammation                                                  1 (2%)                                                          
      Inflammation, Chronic                            5 (9%)                    2 (4%)                                             
      Inflammation, Chronic Active                    32 (56%)     29 (53%)     20 (35%)                                            
      Artery, Inflammation, Chronic Active             1 (2%)                                                                       
      Epithelium, Hyperplasia                          1 (2%)                                                                       
   Seminal Vesicle                                    (59)         (59)         (55)                                                
      Atrophy                                                       1 (2%)       1 (2%)                                             
      Cyst                                                          1 (2%)                                                          
      Fibrosis                                                      3 (5%)                                                          
      Inflammation, Chronic Active                     4 (7%)      14 (24%)     13 (24%)                                            
      Artery, Thrombosis                                            1 (2%)                                                          
   Testes                                             (60)         (59)         (60)                                                
      Atrophy                                                                    2 (3%)                                             
      Inflammation, Chronic Active                                               2 (3%)                                             
      Interstitial Cell, Hyperplasia                                1 (2%)                                                          
      Seminiferous Tubule, Atrophy                     7 (12%)                   4 (7%)                                             
      Seminiferous Tubule, Mineralization              2 (3%)       1 (2%)       3 (5%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (59)         (59)         (59)                                                
      Myeloid Cell, Sternal, Hyperplasia               1 (2%)       2 (3%)       1 (2%)                                             
      Sternal, Infiltration Cellular, Mast Cell        1 (2%)                                                                       
      Sternal, Inflammation, Granulomatous                          1 (2%)                                                          
   Lymph Node                                         (10)         (8)          (11)                                                
      Hyperplasia, Lymphoid                                                      1 (9%)                                             
      Inguinal, Hyperplasia, Lymphoid                  1 (10%)                                                                      
      Lumbar, Hyperplasia                              1 (10%)                                                                      
      Lumbar, Hyperplasia, Lymphoid                    1 (10%)      1 (13%)                                                         
      Lumbar, Hyperplasia, Plasma Cell                                           2 (18%)                                            
      Lumbar, Inflammation, Chronic Active                          1 (13%)                                                         
      Mediastinal, Infiltration Cellular,                                                                                           
          Histiocyte                                                1 (13%)                                                         
      Mediastinal, Inflammation, Chronic Active                                  1 (9%)                                             
      Mediastinal, Pigmentation                                     1 (13%)                                                         
      Pancreatic, Angiectasis                                                    1 (9%)                                             
      Pancreatic, Hyperplasia, Lymphoid                2 (20%)                                                                      
      Pancreatic, Infiltration Cellular, Histiocyte    1 (10%)                                                                      
      Pancreatic, Pigmentation                         1 (10%)                                                                      
      Renal, Angiectasis                               1 (10%)                                                                      
      Renal, Hyperplasia, Lymphoid                     1 (10%)                                                                      
      Renal, Inflammation, Chronic Active                           1 (13%)                                                         
   Lymph Node, Mandibular                             (38)         (43)         (36)                                                
      Depletion Lymphoid                               3 (8%)       1 (2%)       1 (3%)                                             
      Hyperplasia, Lymphoid                            3 (8%)       1 (2%)       1 (3%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   13                                                              
NTP Experiment-Test: 05061-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 05/19/95  
Route: DOSED FEED                                                                                                 Time: 16:49:58  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          UNTREATE     1.0%         2.0%                                                   
                                                   D 71UM       71LM         71HM                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Hyperplasia, Plasma Cell                                      1 (2%)                                                          
      Infiltration Cellular, Histiocyte                3 (8%)                    8 (22%)                                            
      Inflammation, Chronic Active                     1 (3%)       1 (2%)       1 (3%)                                             
      Necrosis, Coagulative                                                      1 (3%)                                             
      Pigmentation                                     5 (13%)      4 (9%)       9 (25%)                                            
   Lymph Node, Mesenteric                             (54)         (56)         (55)                                                
      Angiectasis                                     24 (44%)     11 (20%)     21 (38%)                                            
      Congestion                                                    1 (2%)                                                          
      Depletion Lymphoid                               1 (2%)                    1 (2%)                                             
      Hematopoietic Cell Proliferation                              2 (4%)                                                          
      Hemorrhage                                       1 (2%)                    4 (7%)                                             
      Hyperplasia                                                                1 (2%)                                             
      Hyperplasia, Lymphoid                            6 (11%)      9 (16%)      4 (7%)                                             
      Hyperplasia, Plasma Cell                                      1 (2%)                                                          
      Infiltration Cellular, Histiocyte               24 (44%)     22 (39%)     22 (40%)                                            
      Inflammation, Chronic Active                                  7 (13%)      4 (7%)                                             
      Pigmentation                                    23 (43%)     22 (39%)     20 (36%)                                            
   Spleen                                             (60)         (60)         (58)                                                
      Angiectasis                                      1 (2%)                                                                       
      Congestion                                                                 1 (2%)                                             
      Depletion Lymphoid                               1 (2%)       3 (5%)       3 (5%)                                             
      Fibrosis                                                                   1 (2%)                                             
      Hematopoietic Cell Proliferation                 6 (10%)     14 (23%)     12 (21%)                                            
      Hyperplasia, Lymphoid                                         2 (3%)       1 (2%)                                             
      Inflammation, Chronic Active                     1 (2%)       1 (2%)       2 (3%)                                             
      Necrosis, Coagulative                                         1 (2%)                                                          
   Thymus                                             (44)         (44)         (41)                                                
      Cyst                                             2 (5%)       6 (14%)     12 (29%)                                            
      Cyst, Multiple                                   2 (5%)                                                                       
      Depletion Lymphoid                               2 (5%)       8 (18%)      6 (15%)                                            
      Hyperplasia, Lymphoid                            1 (2%)                                                                       
      Infiltration Cellular, Histiocyte                             1 (2%)                                                          
      Necrosis, Coagulative                                         1 (2%)       1 (2%)                                             
      Pigmentation                                     1 (2%)       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (60)         (57)         (58)                                                
      Inflammation, Acute                              1 (2%)                                                                       
      Inflammation, Chronic Active                     4 (7%)       9 (16%)     13 (22%)                                            
      Subcutaneous Tissue, Abscess                                               1 (2%)                                             
      Subcutaneous Tissue, Cyst                                     1 (2%)                                                          
      Subcutaneous Tissue, Fibrosis                                 2 (4%)       1 (2%)                                             
      Subcutaneous Tissue, Inflammation, Acute         2 (3%)                                                                       
      Subcutaneous Tissue, Inflammation, Chronic                                                                                    
          Active                                                                 1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   14                                                              
NTP Experiment-Test: 05061-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 05/19/95  
Route: DOSED FEED                                                                                                 Time: 16:49:58  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          UNTREATE     1.0%         2.0%                                                   
                                                   D 71UM       71LM         71HM                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (51)         (52)         (59)                                                
      Cartilage, Tarsal, Hyperplasia                   1 (2%)                                                                       
      Joint, Tarsal, Hyperostosis                     12 (24%)     13 (25%)     12 (20%)                                            
   Skeletal Muscle                                    (3)          (3)          (3)                                                 
      Fibrosis                                         1 (33%)                                                                      
      Intercostal, Inflammation, Chronic Active                                  1 (33%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (60)         (60)         (60)                                                
      Cyst Epithelial Inclusion                                                  1 (2%)                                             
      Cerebellum, Necrosis                             1 (2%)                                                                       
      Cerebrum, Necrosis                               1 (2%)                                                                       
      Thalamus, Mineralization                        26 (43%)     20 (33%)     19 (32%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (60)         (60)                                                
      Bronchiectasis                                                1 (2%)                                                          
      Congestion                                       1 (2%)                    1 (2%)                                             
      Crystals                                                      1 (2%)                                                          
      Foreign Body                                                  1 (2%)                                                          
      Granuloma                                                     1 (2%)                                                          
      Hemorrhage                                       9 (15%)      9 (15%)     10 (17%)                                            
      Infiltration Cellular, Histiocyte                2 (3%)       2 (3%)       6 (10%)                                            
      Inflammation, Acute                                           2 (3%)                                                          
      Inflammation, Chronic Active                     1 (2%)       3 (5%)       1 (2%)                                             
      Mineralization                                   1 (2%)                                                                       
      Pigmentation                                                               1 (2%)                                             
      Alveolar Epithelium, Hyperplasia                 1 (2%)                    4 (7%)                                             
      Bronchiole, Hyperplasia                          1 (2%)                                                                       
      Bronchiole, Metaplasia, Squamous                              1 (2%)                                                          
      Peribronchiolar, Inflammation, Chronic           1 (2%)                                                                       
      Perivascular, Inflammation, Chronic              1 (2%)                                                                       
   Nose                                               (53)         (58)         (58)                                                
      Crystals                                         1 (2%)                                                                       
      Inflammation, Acute                             13 (25%)     11 (19%)      6 (10%)                                            
      Glands, Crystals                                 2 (4%)                                                                       
      Glands, Inflammation, Acute                                                2 (3%)                                             
      Nasolacrimal Duct, Inflammation, Acute           2 (4%)                                                                       
      Respiratory Epithelium, Necrosis                                           1 (2%)                                             
   Trachea                                            (60)         (59)         (60)                                                
      Inflammation, Acute                              2 (3%)                    3 (5%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   15                                                              
NTP Experiment-Test: 05061-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 05/19/95  
Route: DOSED FEED                                                                                                 Time: 16:49:58  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          UNTREATE     1.0%         2.0%                                                   
                                                   D 71UM       71LM         71HM                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (2)          (1)                                                              
      Anterior, Synechia                                            1 (100%)                                                        
      Cornea, Fibrosis                                              1 (100%)                                                        
      Cornea, Inflammation, Chronic Active             1 (50%)                                                                      
   Harderian Gland                                    (2)          (2)          (1)                                                 
      Inflammation, Chronic Active                     1 (50%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (52)         (60)                                                
      Autolysis                                                     1 (2%)                                                          
      Congestion                                                    1 (2%)                                                          
      Cyst                                             1 (2%)                    1 (2%)                                             
      Glomerulosclerosis                                            3 (6%)                                                          
      Infiltration Cellular, Mononuclear Cell                       1 (2%)                                                          
      Inflammation, Acute, Necrotizing                                           1 (2%)                                             
      Inflammation, Chronic                           10 (17%)      1 (2%)       8 (13%)                                            
      Inflammation, Chronic Active                    47 (78%)     42 (81%)     47 (78%)                                            
      Metaplasia, Osseous                                                        1 (2%)                                             
      Mineralization                                                             1 (2%)                                             
      Necrosis, Coagulative                                         1 (2%)                                                          
      Artery, Necrosis, Fibrinoid                                   1 (2%)                                                          
      Pelvis, Transitional Epithelium, Hyperplasia                  1 (2%)                                                          
      Proximal Convoluted Renal Tubule, Hyperplasia                 1 (2%)                                                          
      Proximal Convoluted Renal Tubule,                                                                                             
          Regeneration                                 2 (3%)      11 (21%)      1 (2%)                                             
      Proximal Convoluted Renal Tubule,                                                                                             
          Vacuolization Cytoplasmic                    1 (2%)                                                                       
      Renal Tubule, Mineralization                     1 (2%)       4 (8%)       1 (2%)                                             
      Renal Tubule, Pigmentation                                   42 (81%)     43 (72%)                                            
      Renal Tubule, Regeneration                       4 (7%)       1 (2%)       4 (7%)                                             
   Urinary Bladder                                    (59)         (59)         (59)                                                
      Autolysis                                        2 (3%)       3 (5%)                                                          
      Calculus Micro Observation Only                  5 (8%)       2 (3%)                                                          
      Inflammation, Chronic                            3 (5%)       7 (12%)      5 (8%)                                             
      Inflammation, Chronic Active                    37 (63%)     31 (53%)     34 (58%)                                            
      Transitional Epithelium, Hyperplasia                          2 (3%)                                                          
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   16                                                              
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
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NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.