National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/1740

TR 383 Mouse Pathology Tables


                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE


NTP Experiment-Test: 05061-02                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 05/19/95
Route: DOSED FEED                                                                                                 Time: 16:51:50




       Facility:  TSI Mason Research

       Chemical CAS #:  81-49-2

       Lock Date:  03/25/92

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05061-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 05/19/95  
Route: DOSED FEED                                                                                                 Time: 16:51:50  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        UNTREATE     1.0%         2.0%                                                   
                                                   D 71UF       71LF         71HF                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          60           60           60                                                  
  Scheduled Sacrifice                                 10           10           10                                                  
  Early Deaths                                                                                                                      
    Moribund                                           5           11           11                                                  
    Dead                                               6            5            6                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                38           33           33                                                  
    Moribund                                           1                                                                            
    Dead                                                            1                                                               
  Animals Examined Microscopically                    60           60           60                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (60)         (55)         (57)                                                
      Basosquamous Tumor Malignant, Metastatic,                                                                                     
           Uterus                                      1 (2%)                                                                       
   Gallbladder                                        (59)         (57)         (54)                                                
      Basosquamous Tumor Malignant, Metastatic,                                                                                     
           Uterus                                      1 (2%)                                                                       
   Intestine Large, Colon                             (60)         (60)         (58)                                                
   Intestine Small, Duodenum                          (58)         (60)         (56)                                                
   Intestine Small, Jejunum                           (57)         (60)         (56)                                                
   Intestine Small, Ileum                             (58)         (60)         (56)                                                
   Liver                                              (60)         (60)         (60)                                                
      Fibrosarcoma, Metastatic, Skin                                1 (2%)                                                          
      Hemangioma                                       1 (2%)                                                                       
      Hepatoblastoma                                                             2 (3%)                                             
      Hepatocellular Carcinoma                                     10 (17%)     15 (25%)                                            
      Hepatocellular Carcinoma, Multiple                           13 (22%)     13 (22%)                                            
      Hepatocellular Adenoma                           6 (10%)      6 (10%)      7 (12%)                                            
      Hepatocellular Adenoma, Multiple                             41 (68%)     49 (82%)                                            
      Squamous Cell Carcinoma, Metastatic, Stomach,                                                                                 
           Forestomach                                              3 (5%)       4 (7%)                                             
   Mesentery                                          (6)          (9)          (8)                                                 
      Basosquamous Tumor Malignant, Metastatic,                                                                                     
           Uterus                                      1 (17%)                                                                      
      Fibrosarcoma, Metastatic, Skin                                1 (11%)                                                         
      Sarcoma, Metastatic, Stomach, Forestomach                                  1 (13%)                                            
      Squamous Cell Carcinoma, Metastatic, Stomach,                                                                                 
           Forestomach                                              2 (22%)      3 (38%)                                            
   Pancreas                                           (60)         (60)         (59)                                                
      Basosquamous Tumor Malignant, Metastatic,                                                                                     
                                                             Page   2                                                               
NTP Experiment-Test: 05061-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 05/19/95  
Route: DOSED FEED                                                                                                 Time: 16:51:50  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        UNTREATE     1.0%         2.0%                                                   
                                                   D 71UF       71LF         71HF                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - cont                                                                                                            
           Uterus                                      1 (2%)                                                                       
      Fibrosarcoma, Metastatic, Skin                                1 (2%)                                                          
      Squamous Cell Carcinoma, Metastatic, Stomach,                                                                                 
           Forestomach                                              1 (2%)       2 (3%)                                             
   Salivary Glands                                    (59)         (60)         (57)                                                
   Stomach, Forestomach                               (58)         (60)         (60)                                                
      Sarcoma                                                                    1 (2%)                                             
      Squamous Cell Carcinoma                                      12 (20%)     11 (18%)                                            
      Squamous Cell Papilloma                          2 (3%)      16 (27%)     15 (25%)                                            
      Squamous Cell Papilloma, Multiple                             4 (7%)      14 (23%)                                            
   Stomach, Glandular                                 (59)         (58)         (58)                                                
      Sarcoma                                                                    1 (2%)                                             
      Squamous Cell Carcinoma, Metastatic, Stomach,                                                                                 
           Forestomach                                              3 (5%)       3 (5%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (60)         (60)         (59)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (60)         (59)         (58)                                                
      Carcinoma                                        1 (2%)                                                                       
      Squamous Cell Carcinoma, Metastatic                                        1 (2%)                                             
   Adrenal Medulla                                    (59)         (59)         (58)                                                
   Islets, Pancreatic                                 (49)         (50)         (48)                                                
      Adenoma                                          2 (4%)       1 (2%)                                                          
   Pituitary Gland                                    (51)         (55)         (52)                                                
      Pars Distalis, Adenoma                           1 (2%)       8 (15%)      4 (8%)                                             
      Pars Distalis, Adenoma, Multiple                              1 (2%)                                                          
      Pars Intermedia, Adenoma                         1 (2%)                                                                       
      Pars Nervosa, Adenoma                                                      1 (2%)                                             
   Thyroid Gland                                      (60)         (60)         (58)                                                
      Follicular Cell, Adenoma                         3 (5%)       1 (2%)       2 (3%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                                      (1)                                                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   3                                                               
NTP Experiment-Test: 05061-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 05/19/95  
Route: DOSED FEED                                                                                                 Time: 16:51:50  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        UNTREATE     1.0%         2.0%                                                   
                                                   D 71UF       71LF         71HF                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (59)         (51)         (57)                                                
      Basosquamous Tumor Malignant, Metastatic,                                                                                     
           Uterus                                      1 (2%)                                                                       
      Granulosa Cell Tumor Benign                      1 (2%)                                                                       
      Hemangioma                                       1 (2%)                                                                       
      Luteoma                                                       1 (2%)                                                          
      Squamous Cell Carcinoma, Metastatic, Stomach,                                                                                 
           Forestomach                                              1 (2%)       3 (5%)                                             
   Uterus                                             (59)         (60)         (59)                                                
      Leiomyoma                                        2 (3%)                                                                       
      Polyp Stromal                                                 2 (3%)                                                          
      Sarcoma Stromal                                               3 (5%)                                                          
      Cervix, Basosquamous Tumor Malignant             1 (2%)                                                                       
   Vagina                                                                       (1)                                                 
      Squamous Cell Carcinoma                                                    1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (60)         (59)         (59)                                                
   Lymph Node                                         (7)          (12)         (12)                                                
      Bronchial, Sarcoma, Metastatic, Stomach,                                                                                      
           Forestomach                                                           1 (8%)                                             
      Mediastinal, Squamous Cell Carcinoma,                                                                                         
          Metastatic, Stomach, Forestomach                          1 (8%)       1 (8%)                                             
      Renal, Basosquamous Tumor Malignant,                                                                                          
          Metastatic, Uterus                           1 (14%)                                                                      
   Lymph Node, Mandibular                             (38)         (55)         (41)                                                
   Lymph Node, Mesenteric                             (56)         (56)         (52)                                                
      Basosquamous Tumor Malignant, Metastatic,                                                                                     
           Uterus                                      1 (2%)                                                                       
      Sarcoma, Metastatic, Stomach, Forestomach                                  1 (2%)                                             
      Squamous Cell Carcinoma, Metastatic, Stomach,                                                                                 
           Forestomach                                              1 (2%)       1 (2%)                                             
   Spleen                                             (60)         (60)         (59)                                                
      Hemangioma                                       1 (2%)                                                                       
      Squamous Cell Carcinoma, Metastatic, Stomach,                                                                                 
           Forestomach                                                           1 (2%)                                             
   Thymus                                             (49)         (48)         (42)                                                
      Osteosarcoma, Metastatic, Bone                   1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   4                                                               
NTP Experiment-Test: 05061-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 05/19/95  
Route: DOSED FEED                                                                                                 Time: 16:51:50  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        UNTREATE     1.0%         2.0%                                                   
                                                   D 71UF       71LF         71HF                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (35)         (35)         (30)                                                
      Fibroadenoma                                     1 (3%)                                                                       
   Skin                                               (60)         (60)         (60)                                                
      Squamous Cell Papilloma                          1 (2%)                                                                       
      Subcutaneous Tissue, Fibrosarcoma                2 (3%)       1 (2%)                                                          
      Subcutaneous Tissue, Hemangioma                  1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (48)         (59)                                                
      Rib, Osteosarcoma                                1 (2%)                                                                       
   Skeletal Muscle                                    (4)          (2)          (2)                                                 
      Abdominal, Fibrosarcoma, Metastatic, Skin                     1 (50%)                                                         
      Diaphragm, Basosquamous Tumor Malignant,                                                                                      
           Metastatic, Uterus                          1 (25%)                                                                      
      Diaphragm, Squamous Cell Carcinoma,                                                                                           
          Metastatic, Stomach, Forestomach                          1 (50%)      1 (50%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (59)         (60)         (60)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (60)         (59)                                                
      Alveolar/Bronchiolar Adenoma                     4 (7%)      18 (30%)     14 (24%)                                            
      Alveolar/Bronchiolar Adenoma, Multiple                        2 (3%)       1 (2%)                                             
      Alveolar/Bronchiolar Carcinoma                                             2 (3%)                                             
      Basosquamous Tumor Malignant, Metastatic,                                                                                     
           Uterus                                      1 (2%)                                                                       
      Hemangioma                                                                 1 (2%)                                             
      Hepatocellular Carcinoma, Metastatic, Liver                                1 (2%)                                             
      Osteosarcoma, Metastatic, Bone                   1 (2%)                                                                       
      Squamous Cell Carcinoma, Metastatic, Stomach,                                                                                 
           Forestomach                                              1 (2%)                                                          
   Nose                                               (58)         (55)         (53)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   5                                                               
NTP Experiment-Test: 05061-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 05/19/95  
Route: DOSED FEED                                                                                                 Time: 16:51:50  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        UNTREATE     1.0%         2.0%                                                   
                                                   D 71UF       71LF         71HF                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (1)          (3)          (2)                                                 
      Adenoma                                          1 (100%)     2 (67%)      2 (100%)                                           
      Carcinoma                                                     1 (33%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (54)         (60)                                                
      Osteosarcoma, Metastatic, Bone                   1 (2%)                                                                       
   Urinary Bladder                                    (59)         (60)         (60)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(60)        *(60)        *(60)                                                
      Lymphoma Malignant Histiocytic                   1 (2%)                                                                       
      Lymphoma Malignant Lymphocytic                   1 (2%)                                                                       
      Lymphoma Malignant Mixed                         9 (15%)     13 (22%)     13 (22%)                                            
      Lymphoma Malignant Undifferentiated Cell                      2 (3%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   6                                                               
NTP Experiment-Test: 05061-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 05/19/95  
Route: DOSED FEED                                                                                                 Time: 16:51:50  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        UNTREATE     1.0%         2.0%                                                   
                                                   D 71UF       71LF         71HF                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            32          55          59                                                   
     Total Primary Neoplasms                           45         158         169                                                   
                                                                                                                                    
   Total Animals with Benign Neoplasms                 24          51          58                                                   
     Total Benign Neoplasms                            29         103         110                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms              14          40          38                                                   
     Total Malignant Neoplasms                         16          55          59                                                   
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              2           4           6                                                   
     Total Metastatic Neoplasm                         12          18          24                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   7                                                               
NTP Experiment-Test: 05061-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 05/19/95  
Route: DOSED FEED                                                                                                 Time: 16:51:50  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          UNTREATE     1.0%         2.0%                                                   
                                                   D 71UM       71LM         71HM                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          60           60           60                                                  
  Scheduled Sacrifice                                 10            9           10                                                  
  Early Deaths                                                                                                                      
    Moribund                                           7           23           21                                                  
    Dead                                               3            5            6                                                  
    Accident                                                        1                                                               
  Survivors                                                                                                                         
    Terminal Sacrifice                                40           22           23                                                  
  Animals Examined Microscopically                    60           60           60                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (56)         (56)         (51)                                                
      Sarcoma, Metastatic, Stomach, Forestomach                     1 (2%)                                                          
      Squamous Cell Carcinoma, Metastatic, Stomach,                                                                                 
           Forestomach                                              1 (2%)       1 (2%)                                             
   Intestine Large, Colon                             (60)         (58)         (60)                                                
      Mast Cell Tumor Malignant                                     1 (2%)                                                          
      Squamous Cell Carcinoma, Metastatic, Stomach,                                                                                 
           Forestomach                                                           1 (2%)                                             
   Intestine Large, Rectum                            (58)         (58)         (58)                                                
      Squamous Cell Carcinoma, Metastatic, Stomach,                                                                                 
           Forestomach                                                           1 (2%)                                             
   Intestine Large, Cecum                             (59)         (60)         (60)                                                
      Adenocarcinoma                                                             1 (2%)                                             
      Mast Cell Tumor Malignant                                     1 (2%)                                                          
      Squamous Cell Carcinoma, Metastatic, Stomach,                                                                                 
           Forestomach                                                           1 (2%)                                             
   Intestine Small, Duodenum                          (60)         (59)         (56)                                                
      Mast Cell Tumor Malignant                                     1 (2%)                                                          
      Polyp Adenomatous                                1 (2%)                                                                       
      Squamous Cell Carcinoma, Metastatic, Stomach,                                                                                 
           Forestomach                                                           1 (2%)                                             
   Intestine Small, Jejunum                           (60)         (56)         (58)                                                
      Mast Cell Tumor Malignant                                     1 (2%)                                                          
      Squamous Cell Carcinoma, Metastatic, Stomach,                                                                                 
           Forestomach                                                           1 (2%)                                             
   Intestine Small, Ileum                             (60)         (58)         (57)                                                
      Adenocarcinoma                                                1 (2%)       2 (4%)                                             
      Histiocytic Sarcoma                                           1 (2%)                                                          
      Mast Cell Tumor Malignant                                     1 (2%)                                                          
   Liver                                              (60)         (60)         (60)                                                
                                                             Page   8                                                               
NTP Experiment-Test: 05061-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 05/19/95  
Route: DOSED FEED                                                                                                 Time: 16:51:50  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          UNTREATE     1.0%         2.0%                                                   
                                                   D 71UM       71LM         71HM                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - cont                                                                                                            
      Fibrosarcoma, Metastatic, Stomach,                                                                                            
          Forestomach                                                            1 (2%)                                             
      Hemangiosarcoma                                               2 (3%)       1 (2%)                                             
      Hemangiosarcoma, Multiple                        3 (5%)                                                                       
      Hepatoblastoma                                                3 (5%)       5 (8%)                                             
      Hepatocellular Carcinoma                         8 (13%)     16 (27%)     12 (20%)                                            
      Hepatocellular Carcinoma, Multiple               1 (2%)       3 (5%)       9 (15%)                                            
      Hepatocellular Adenoma                           4 (7%)      11 (18%)     12 (20%)                                            
      Hepatocellular Adenoma, Multiple                 6 (10%)     29 (48%)     31 (52%)                                            
      Hepatocholangiocarcinoma, Multiple                                         1 (2%)                                             
      Histiocytic Sarcoma                                           1 (2%)       1 (2%)                                             
      Sarcoma, Metastatic, Stomach, Forestomach                     1 (2%)                                                          
      Squamous Cell Carcinoma, Metastatic, Tissue                                                                                   
          NOS                                                       1 (2%)                                                          
      Squamous Cell Carcinoma, Metastatic, Stomach,                                                                                 
           Forestomach                                              4 (7%)       4 (7%)                                             
   Mesentery                                          (2)          (8)          (9)                                                 
      Sarcoma, Metastatic, Stomach, Forestomach                     1 (13%)                                                         
      Squamous Cell Carcinoma, Metastatic, Stomach,                                                                                 
           Forestomach                                              2 (25%)      5 (56%)                                            
   Pancreas                                           (60)         (59)         (58)                                                
      Histiocytic Sarcoma                                           1 (2%)                                                          
      Sarcoma, Metastatic, Stomach, Forestomach                     1 (2%)                                                          
      Squamous Cell Carcinoma, Metastatic, Stomach,                                                                                 
           Forestomach                                              1 (2%)       1 (2%)                                             
   Salivary Glands                                    (60)         (59)         (60)                                                
   Stomach, Forestomach                               (59)         (59)         (60)                                                
      Leiomyosarcoma                                                1 (2%)                                                          
      Mast Cell Tumor Malignant                                     1 (2%)                                                          
      Squamous Cell Carcinoma                                      12 (20%)     14 (23%)                                            
      Squamous Cell Papilloma                                      11 (19%)     11 (18%)                                            
      Squamous Cell Papilloma, Multiple                             2 (3%)       5 (8%)                                             
   Stomach, Glandular                                 (59)         (59)         (59)                                                
      Histiocytic Sarcoma                                           1 (2%)                                                          
      Mast Cell Tumor Malignant                                     1 (2%)                                                          
      Sarcoma                                                       1 (2%)                                                          
      Squamous Cell Carcinoma, Metastatic, Stomach,                                                                                 
           Forestomach                                              3 (5%)       4 (7%)                                             
   Tooth                                              (4)                       (7)                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (60)         (60)         (60)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   9                                                               
NTP Experiment-Test: 05061-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 05/19/95  
Route: DOSED FEED                                                                                                 Time: 16:51:50  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          UNTREATE     1.0%         2.0%                                                   
                                                   D 71UM       71LM         71HM                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (60)         (60)         (60)                                                
      Adenoma                                          2 (3%)       1 (2%)                                                          
      Sarcoma, Metastatic, Stomach, Forestomach                     1 (2%)                                                          
   Adrenal Medulla                                    (60)         (59)         (60)                                                
      Pheochromocytoma Benign                                                    1 (2%)                                             
   Pituitary Gland                                    (52)         (54)         (56)                                                
      Pars Distalis, Adenoma                                        2 (4%)                                                          
   Thyroid Gland                                      (59)         (59)         (59)                                                
      C-Cell, Adenoma                                                            1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                         (1)          (1)          (1)                                                 
      Squamous Cell Carcinoma                                       1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Coagulating Gland                                  (1)          (1)          (1)                                                 
      Squamous Cell Carcinoma, Metastatic, Stomach,                                                                                 
           Forestomach                                              1 (100%)     1 (100%)                                           
   Epididymis                                         (59)         (60)         (60)                                                
      Fibrosarcoma, Metastatic, Stomach,                                                                                            
          Forestomach                                                            1 (2%)                                             
      Histiocytic Sarcoma                                           1 (2%)                                                          
      Sarcoma, Metastatic, Stomach, Forestomach                     1 (2%)                                                          
      Squamous Cell Carcinoma, Metastatic, Stomach,                                                                                 
           Forestomach                                              1 (2%)       1 (2%)                                             
   Preputial Gland                                    (21)         (16)         (13)                                                
      Squamous Cell Carcinoma                          2 (10%)                                                                      
   Prostate                                           (57)         (55)         (57)                                                
      Histiocytic Sarcoma                                           1 (2%)                                                          
      Squamous Cell Carcinoma, Metastatic,                                                                                          
          Preputial Gland                              1 (2%)                                                                       
      Squamous Cell Carcinoma, Metastatic, Stomach,                                                                                 
           Forestomach                                                           1 (2%)                                             
   Seminal Vesicle                                    (59)         (59)         (55)                                                
      Fibrosarcoma, Metastatic, Stomach,                                                                                            
          Forestomach                                                            1 (2%)                                             
      Histiocytic Sarcoma                                           1 (2%)                                                          
      Squamous Cell Carcinoma, Metastatic, Stomach,                                                                                 
           Forestomach                                                           1 (2%)                                             
   Testes                                             (60)         (59)         (60)                                                
      Sarcoma, Metastatic, Stomach, Forestomach                     1 (2%)                                                          
      Squamous Cell Carcinoma, Metastatic, Stomach,                                                                                 
                                                             Page  10                                                               
NTP Experiment-Test: 05061-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 05/19/95  
Route: DOSED FEED                                                                                                 Time: 16:51:50  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          UNTREATE     1.0%         2.0%                                                   
                                                   D 71UM       71LM         71HM                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - cont                                                                                                               
           Forestomach                                                           1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (59)         (59)         (59)                                                
      Mast Cell Tumor Malignant                                     1 (2%)                                                          
   Lymph Node                                         (10)         (8)          (11)                                                
      Lumbar, Histiocytic Sarcoma                                   1 (13%)                                                         
      Mediastinal, Histiocytic Sarcoma                              1 (13%)                                                         
      Mediastinal, Squamous Cell Carcinoma,                                                                                         
          Metastatic, Stomach, Forestomach                          2 (25%)      1 (9%)                                             
      Pancreatic, Histiocytic Sarcoma                               1 (13%)                                                         
      Pancreatic, Squamous Cell Carcinoma,                                                                                          
          Metastatic, Stomach, Forestomach                                       1 (9%)                                             
      Renal, Histiocytic Sarcoma                                    1 (13%)                                                         
   Lymph Node, Mandibular                             (38)         (43)         (36)                                                
      Histiocytic Sarcoma                                           1 (2%)                                                          
      Mast Cell Tumor Malignant                                     1 (2%)                                                          
   Lymph Node, Mesenteric                             (54)         (56)         (55)                                                
      Histiocytic Sarcoma                                           1 (2%)                                                          
      Mast Cell Tumor Malignant                                     1 (2%)                                                          
      Sarcoma, Metastatic, Stomach, Forestomach                     1 (2%)                                                          
      Squamous Cell Carcinoma, Metastatic, Stomach,                                                                                 
           Forestomach                                              2 (4%)                                                          
   Spleen                                             (60)         (60)         (58)                                                
      Hemangiosarcoma                                               1 (2%)       1 (2%)                                             
      Histiocytic Sarcoma                                           1 (2%)                                                          
      Mast Cell Tumor Malignant                                     2 (3%)                                                          
      Squamous Cell Carcinoma, Metastatic, Stomach,                                                                                 
           Forestomach                                              1 (2%)                                                          
   Thymus                                             (44)         (44)         (41)                                                
      Mast Cell Tumor Malignant                                     1 (2%)                                                          
      Squamous Cell Carcinoma, Metastatic, Stomach,                                                                                 
           Forestomach                                              1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (60)         (57)         (58)                                                
      Mast Cell Tumor Malignant                                     1 (2%)                                                          
      Squamous Cell Carcinoma                                       1 (2%)                                                          
      Squamous Cell Papilloma                          1 (2%)                                                                       
      Subcutaneous Tissue, Fibroma                     2 (3%)       2 (4%)       1 (2%)                                             
      Subcutaneous Tissue, Fibroma, Multiple                        1 (2%)                                                          
      Subcutaneous Tissue, Fibrosarcoma                3 (5%)       8 (14%)      2 (3%)                                             
      Subcutaneous Tissue, Sarcoma                     1 (2%)                                                                       
                                                             Page  11                                                               
NTP Experiment-Test: 05061-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 05/19/95  
Route: DOSED FEED                                                                                                 Time: 16:51:50  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          UNTREATE     1.0%         2.0%                                                   
                                                   D 71UM       71LM         71HM                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                    (3)          (3)          (3)                                                 
      Abdominal, Squamous Cell Carcinoma,                                                                                           
          Metastatic, Stomach, Forestomach                                       2 (67%)                                            
      Diaphragm, Sarcoma, Metastatic, Stomach,                                                                                      
           Forestomach                                              1 (33%)                                                         
      Diaphragm, Squamous Cell Carcinoma,                                                                                           
          Metastatic, Stomach, Forestomach                          2 (67%)      1 (33%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (60)         (60)         (60)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (60)         (60)                                                
      Alveolar/Bronchiolar Adenoma                     7 (12%)     23 (38%)     20 (33%)                                            
      Alveolar/Bronchiolar Adenoma, Multiple                        6 (10%)      9 (15%)                                            
      Alveolar/Bronchiolar Carcinoma                   3 (5%)       3 (5%)       1 (2%)                                             
      Alveolar/Bronchiolar Carcinoma, Multiple                      1 (2%)                                                          
      Hepatocellular Carcinoma, Metastatic             1 (2%)                    2 (3%)                                             
      Hepatocellular Carcinoma, Metastatic, Liver      2 (3%)                                                                       
      Histiocytic Sarcoma                                           1 (2%)       1 (2%)                                             
      Sarcoma, Metastatic, Stomach, Forestomach                     1 (2%)                                                          
      Squamous Cell Carcinoma, Metastatic, Stomach,                                                                                 
           Forestomach                                              3 (5%)                                                          
      Mediastinum, Hemangiosarcoma, Metastatic,                                                                                     
           Spleen                                                                1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                (1)          (1)          (1)                                                 
      Fibrosarcoma                                     1 (100%)                                                                     
   Harderian Gland                                    (2)          (2)          (1)                                                 
      Adenoma                                          2 (100%)     2 (100%)     1 (100%)                                           
   Lacrimal Gland                                                               (1)                                                 
      Adenoma                                                                    1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page  12                                                               
NTP Experiment-Test: 05061-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 05/19/95  
Route: DOSED FEED                                                                                                 Time: 16:51:50  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          UNTREATE     1.0%         2.0%                                                   
                                                   D 71UM       71LM         71HM                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (52)         (60)                                                
      Histiocytic Sarcoma                                           1 (2%)                                                          
      Mast Cell Tumor Malignant                                     1 (2%)                                                          
      Squamous Cell Carcinoma, Metastatic, Stomach,                                                                                 
           Forestomach                                              2 (4%)                                                          
   Urinary Bladder                                    (59)         (59)         (59)                                                
      Histiocytic Sarcoma                                           1 (2%)                                                          
      Mast Cell Tumor Malignant                                     1 (2%)                                                          
      Papilloma                                                                  1 (2%)                                             
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(60)        *(60)        *(60)                                                
      Histiocytic Sarcoma                                           1 (2%)       1 (2%)                                             
      Lymphoma Malignant Histiocytic                   1 (2%)       1 (2%)                                                          
      Lymphoma Malignant Lymphocytic                   1 (2%)                    1 (2%)                                             
      Lymphoma Malignant Mixed                         7 (12%)      3 (5%)       5 (8%)                                             
      Lymphoma Malignant Undifferentiated Cell         2 (3%)       2 (3%)       1 (2%)                                             
      Mesothelioma Malignant                                        1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  13                                                               
NTP Experiment-Test: 05061-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 05/19/95  
Route: DOSED FEED                                                                                                 Time: 16:51:50  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          UNTREATE     1.0%         2.0%                                                   
                                                   D 71UM       71LM         71HM                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            38          53          55                                                   
     Total Primary Neoplasms                           58         168         151                                                   
                                                                                                                                    
   Total Animals with Benign Neoplasms                 20          47          50                                                   
     Total Benign Neoplasms                            25          90          94                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms              26          40          40                                                   
     Total Malignant Neoplasms                         33          78          57                                                   
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              4           7           9                                                   
     Total Metastatic Neoplasm                          4          37          36                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  14                                                               
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NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.