National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/1744

TR 383 Mouse Pathology Tables

NTP Experiment-Test: 05061-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97
Route: DOSED FEED                                                                                                 Time: 09:33:30




       Facility:  TSI Mason Research

       Chemical CAS #:  81-49-2

       Lock Date:  03/25/92

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All






































                                                              Page   1

NTP Experiment-Test: 05061-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 09:33:30  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 7| 7| 6| 4| 7| 7| 7| 5| 7| 7| 4| 6| 4| 7| 7| 7| 7| 4| 7| 4| 4| 7| 7|             
                             DAY ON TEST   | 5| 5| 3| 3| 8| 5| 3| 3| 3| 9| 3| 3| 5| 1| 7| 3| 3| 3| 0| 5| 3| 5| 5| 3| 3|             
                                           | 7| 5| 4| 2| 5| 5| 3| 3| 4| 2| 3| 3| 5| 0| 8| 3| 3| 3| 1| 5| 3| 5| 7| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    UNTREATE                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    D 71UF                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |             3                          3                                 |             
      Inflammation, Chronic                |    1                                                                     |             
      Inflammation, Chronic Active         |                      1                                         1         |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |             3              3                                             |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |             1                                                            |             
      Peyer's Patch, Epithelium,           |                                                                          |             
          Proliferation                    |                                                                         2|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |             4              1           3                                 |             
      Peyer's Patch, Hyperplasia           |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                            1                                             |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                            4                                             |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                            4                                             |             
      Peyer's Patch, Hyperplasia           |                                                                         1|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |             1                                                            |             
      Fatty Change                         | 1                          2                                             |             
      Hematopoietic Cell Proliferation     |                                           2                              |             
      Inflammation, Chronic Active         | 1           1  1  1  1              1        1  1  1     1  1  1  1  1   |             
      Necrosis, Coagulative                | 1        1                          1              1     1     1  1      |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                           +        +  +                  |             
      Inflammation, Chronic Active         |                                                    3                     |             
      Mineralization                       |                                                                          |             
      Necrosis, Coagulative                |                                                    3                     |             
      Pigmentation                         |                                                    2                     |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cytoplasmic Alteration               |                                                                          |             
      Inflammation, Chronic                |                1                    1                    1        1      |             
      Inflammation, Chronic Active         |       2     1     1  1  1        1                          2        1  1|             
      Vacuolization Cytoplasmic            |                               1  2        2     1  2  2              1  1|             
      Duct, Dilatation                     |                                                             4            |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Sublingual Gland, Inflammation,      |                                                                          |             
          Chronic                          |                                                                          |             
      Submandibular Gland, Inflammation,   |                                                                          |             
           Chronic                         |    1  1     1  1  1  1  1        1  1  1  1  1  1  1     1  1  1     1   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05061-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 09:33:30  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 7| 7| 6| 4| 7| 7| 7| 5| 7| 7| 4| 6| 4| 7| 7| 7| 7| 4| 7| 4| 4| 7| 7|             
                             DAY ON TEST   | 5| 5| 3| 3| 8| 5| 3| 3| 3| 9| 3| 3| 5| 1| 7| 3| 3| 3| 0| 5| 3| 5| 5| 3| 3|             
                                           | 7| 5| 4| 2| 5| 5| 3| 3| 4| 2| 3| 3| 5| 0| 8| 3| 3| 3| 1| 5| 3| 5| 7| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    UNTREATE                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    D 71UF                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Acanthosis                           |          1           2                          2     2                  |             
      Hyperkeratosis                       |          1           2                    2     1     1                  |             
      Inflammation, Chronic Active         |                                                 2     1                  |             
      Ulcer                                |                                                                          |             
      Ulcer, Multiple                      |                                                 2                        |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                        2                                 |             
      Inflammation, Chronic                | 1                                                                        |             
      Inflammation, Chronic Active         |       1           1  1           1              1     1     1  1        2|             
      Mineralization                       |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Abscess                              |                                                                          |             
      Dysplasia                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |                1                                               1         |             
      Inflammation, Chronic                |       1                                   1        1                 1   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |             2              1                                             |             
      Hematopoietic Cell Proliferation     |                                           1                              |             
      Inflammation, Chronic Active         |          2                                2                              |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |       +  +  +     +  +  +  +  +  +     +  +  +  M  +  +     +        +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  M  +  +  +  +  +  +  M  +  M  +  +  +  M  M  +  +  +  M  +  +  +  +|             
      Cyst                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  M  +  +  M  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Pars Distalis, Angiectasis           |                                                                          |             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hyperplasia           |                1                                            2            |             
      Pars Distalis, Pigmentation          |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      C-Cell, Hyperplasia                  |                                                                          |             
      Follicle, Cyst                       |                                                                          |             
      Follicular Cell, Hyperplasia         |                   1                                                      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05061-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 09:33:30  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 7| 7| 6| 4| 7| 7| 7| 5| 7| 7| 4| 6| 4| 7| 7| 7| 7| 4| 7| 4| 4| 7| 7|             
                             DAY ON TEST   | 5| 5| 3| 3| 8| 5| 3| 3| 3| 9| 3| 3| 5| 1| 7| 3| 3| 3| 0| 5| 3| 5| 5| 3| 3|             
                                           | 7| 5| 4| 2| 5| 5| 3| 3| 4| 2| 3| 3| 5| 0| 8| 3| 3| 3| 1| 5| 3| 5| 7| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    UNTREATE                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    D 71UF                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Cyst                                 |             2     2                                3                    4|             
      Cyst, Multiple                       |                                                             2            |             
      Inflammation, Acute, Necrotizing     |                                                                          |             
      Pigmentation                         |                                                                          |             
      Periovarian Tissue, Cyst             |                                                                      4   |             
      Periovarian Tissue, Inflammation,    |                                                                          |             
           Chronic                         |                1                                         1               |             
      Periovarian Tissue, Inflammation,    |                                                                          |             
           Chronic Active                  |                      1  1     1              1  1  1        1        2  1|             
      Periovarian Tissue, Mineralization   |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydrometra                           |    2     3     3  4  3  2     4                 2  2     2     2  2      |             
      Inflammation, Chronic Active         |                                                                          |             
      Endometrium, Hyperplasia             | 2  2     3  1  2  2     2     2  2  2  1     2  2  2  1  3  3  2     1  3|             
      Epithelium, Metaplasia, Squamous     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Myelofibrosis                        | 1              1                                                         |             
      Myeloid Cell, Sternal, Hyperplasia   |                                           3                              |             
      Sternal, Myelofibrosis               |       1           2  1  2     2  1           2  1  2        2        1  2|             
                                            __________________________________________________________________________|             
   Lymph Node                              |          +              +     +           +           +                  |             
      Lumbar, Hyperplasia, Lymphoid        |                                           2                              |             
      Lumbar, Inflammation, Acute          |                                           2                              |             
      Mediastinal, Inflammation, Chronic   |                                                                          |             
          Active                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  M  +  +  +  +  M  +  M  +  +  M  M  +  +  +  M  +  +  M  +  M  +  +|             
      Congestion                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Hyperplasia, Plasma Cell             |                                                                          |             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Angiectasis                          |                         2     1                                          |             
      Depletion Lymphoid                   |                            3                             2               |             
      Hyperplasia, Lymphoid                |                                                    4                     |             
      Infiltration Cellular, Histiocyte    | 1     1     1     1  1     1           1     1              1  1     1  1|             
      Inflammation, Chronic Active         |                                                                          |             
      Necrosis, Coagulative                |                                                    2                     |             
      Pigmentation                         | 1     1     1     1  1     1           1     1              1  1     1  1|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                        2                                 |             
      Depletion Lymphoid                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05061-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 09:33:30  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 7| 7| 6| 4| 7| 7| 7| 5| 7| 7| 4| 6| 4| 7| 7| 7| 7| 4| 7| 4| 4| 7| 7|             
                             DAY ON TEST   | 5| 5| 3| 3| 8| 5| 3| 3| 3| 9| 3| 3| 5| 1| 7| 3| 3| 3| 0| 5| 3| 5| 5| 3| 3|             
                                           | 7| 5| 4| 2| 5| 5| 3| 3| 4| 2| 3| 3| 5| 0| 8| 3| 3| 3| 1| 5| 3| 5| 7| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    UNTREATE                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    D 71UF                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Fibrosis                             |                                                                          |             
      Hematopoietic Cell Proliferation     |          2  2                             4                              |             
      Hyperplasia, Lymphoid                |                   2                                3                     |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  I  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Cyst                                 | 1  1           1        1                    1     1  1        1  1  1  1|             
      Depletion Lymphoid                   |          3                 3              2                              |             
      Hyperplasia, Lymphoid                |                                  2                                       |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  M  +  +  +  +  M  M  M  +  +  +  +  +  +  +  M  +  M  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                                                         2|             
      Inflammation, Acute                  |                                                                         3|             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic Active                  |                         1                                                |             
      Subcutaneous Tissue, Mineralization  |                                                                         1|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | M  M  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  M  M  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |          +                                +           +                  |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Thalamus, Mineralization             |             1           1     1        1  1              1  1  1     1   |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hemorrhage                           |                                           1     1  1                     |             
      Inflammation, Chronic Active         |                                  2                                       |             
      Leukocytosis                         |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |             1     1              1                          1        1  1|             
      Glands, Inflammation, Acute          |    1                                                                     |             
      Nasolacrimal Duct, Hyperplasia       |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05061-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 09:33:30  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 7| 7| 6| 4| 7| 7| 7| 5| 7| 7| 4| 6| 4| 7| 7| 7| 7| 4| 7| 4| 4| 7| 7|             
                             DAY ON TEST   | 5| 5| 3| 3| 8| 5| 3| 3| 3| 9| 3| 3| 5| 1| 7| 3| 3| 3| 0| 5| 3| 5| 5| 3| 3|             
                                           | 7| 5| 4| 2| 5| 5| 3| 3| 4| 2| 3| 3| 5| 0| 8| 3| 3| 3| 1| 5| 3| 5| 7| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    UNTREATE                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    D 71UF                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Glomerulosclerosis                   |                                                                          |             
      Hydronephrosis                       |                         1                                                |             
      Infarct                              |                                                                          |             
      Inflammation, Chronic                | 1  1  1  1  1  1  1  1  1  1     1  2  1  1  1  1  1     1  1  1  1  1  2|             
      Proximal Convoluted Renal Tubule,    |                                                                          |             
           Degeneration, Hyaline           |                                                                          |             
      Renal Tubule, Casts Protein          |                                                                          |             
      Renal Tubule, Regeneration           | 1                                                        1               |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                            3           3                                 |             
      Inflammation, Chronic                |                1                                         1     1  1      |             
      Inflammation, Chronic Active         |                   1     1  1  1  1     1  1  1  1  1        2        1  1|             
      Submucosa, Proliferation             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   6                                                               
NTP Experiment-Test: 05061-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 09:33:30  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 0| 7| 4| 7| 7| 7| 7| 7| 7| 6| 6|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 5| 3| 3| 3| 3| 3| 0| 5| 2|             
                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 6| 3| 5| 3| 4| 4| 3| 4| 8| 3| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    UNTREATE                               | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
    D 71UF                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                   4      |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         | 1              1                 1                                       |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                   3      |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                   3      |             
      Peyer's Patch, Epithelium,           |                                                                          |             
          Proliferation                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                   3      |             
      Peyer's Patch, Hyperplasia           |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                   3      |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A  +  +|             
      Autolysis                            |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                   3      |             
      Peyer's Patch, Hyperplasia           |                2                       2                                 |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                   2      |             
      Fatty Change                         |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Inflammation, Chronic Active         | 1     1  1     1  1     1  1        1  1     1  1     1  1  1  2        1|             
      Necrosis, Coagulative                |                1           1  2        1        1           1            |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                      +   |             
      Inflammation, Chronic Active         |                                                                          |             
      Mineralization                       |                                                                          |             
      Necrosis, Coagulative                |                                                                          |             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cytoplasmic Alteration               |    1        1                                            1               |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         |          1     1           1  1        1              1     2  2  1     1|             
      Vacuolization Cytoplasmic            | 1           1     1                    1     1     1     2  2  1  1      |             
      Duct, Dilatation                     |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Sublingual Gland, Inflammation,      |                                                                          |             
          Chronic                          |                                                                          |             
      Submandibular Gland, Inflammation,   |                                                                          |             
           Chronic                         | 1  1  1  1     1  2  1     1  1  1  1  2     2  1  1  1  1  1  2  1     2|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   7                                                               
NTP Experiment-Test: 05061-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 09:33:30  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 0| 7| 4| 7| 7| 7| 7| 7| 7| 6| 6|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 5| 3| 3| 3| 3| 3| 0| 5| 2|             
                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 6| 3| 5| 3| 4| 4| 3| 4| 8| 3| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    UNTREATE                               | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
    D 71UF                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Acanthosis                           |                                              2                 1        1|             
      Hyperkeratosis                       |                                              1                 1  2     1|             
      Inflammation, Chronic Active         |                   1                          2                          1|             
      Ulcer                                |                                              2                           |             
      Ulcer, Multiple                      |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Autolysis                            |                                                                   2      |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         | 1  1                 1           1     1     1           1               |             
      Mineralization                       |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                         +|             
      Abscess                              |                                                                         2|             
      Dysplasia                            |                                                                         4|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |                                                                          |             
      Inflammation, Chronic                | 1  1                                      1              1     1         |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                   2                                      1               |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  +  +  M  M  M  +  +  +  +  M  +  +  M  M  +  +  M  +  +  M  +  +  +|             
      Cyst                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  M  +  M  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |    2                                                                     |             
      Pars Distalis, Cyst                  |                         1           1                          1         |             
      Pars Distalis, Hyperplasia           | 2                                            1           1               |             
      Pars Distalis, Pigmentation          |                                                          1               |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |             2                                                            |             
      C-Cell, Hyperplasia                  |                               1                                          |             
      Follicle, Cyst                       |                                                          2               |             
      Follicular Cell, Hyperplasia         |                                              2              1            |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   8                                                               
NTP Experiment-Test: 05061-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 09:33:30  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 0| 7| 4| 7| 7| 7| 7| 7| 7| 6| 6|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 5| 3| 3| 3| 3| 3| 0| 5| 2|             
                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 6| 3| 5| 3| 4| 4| 3| 4| 8| 3| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    UNTREATE                               | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
    D 71UF                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                         2                                   2            |             
      Cyst                                 | 1                    2  2                                   3  1        2|             
      Cyst, Multiple                       |                                                                          |             
      Inflammation, Acute, Necrotizing     |                            2                                             |             
      Pigmentation                         |                            3                                             |             
      Periovarian Tissue, Cyst             |                                                                          |             
      Periovarian Tissue, Inflammation,    |                                                                          |             
           Chronic                         |                                                                          |             
      Periovarian Tissue, Inflammation,    |                                                                          |             
           Chronic Active                  | 1        1  1  1  1  1  1  1           1     1     1     2  2  1  1      |             
      Periovarian Tissue, Mineralization   |                                                             2            |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Hydrometra                           |       2     2        4        2  4           2  2     4                  |             
      Inflammation, Chronic Active         |                            2                                             |             
      Endometrium, Hyperplasia             | 2  2  2  2  2  2  2  1  1  3     2  1  2           2        3  1         |             
      Epithelium, Metaplasia, Squamous     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Myelofibrosis                        |                                                                          |             
      Myeloid Cell, Sternal, Hyperplasia   |                                                                          |             
      Sternal, Myelofibrosis               | 2  2  3  2     2  2  3  1  3     2  2  2     2     2  2  1  3     1     1|             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                                                      +   |             
      Lumbar, Hyperplasia, Lymphoid        |                                                                          |             
      Lumbar, Inflammation, Acute          |                                                                          |             
      Mediastinal, Inflammation, Chronic   |                                                                          |             
          Active                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  +  M  +  +  M  M  +  +  +  +  I  +  +  M  +  M  M  +  +  +  M  M  +  +|             
      Congestion                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                                             2            |             
      Hyperplasia, Plasma Cell             |                                                                          |             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 1  2           1                                                         |             
      Depletion Lymphoid                   |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Infiltration Cellular, Histiocyte    | 1  1  1  1  1  1  1  1  1     1  1     1              1  1  1            |             
      Inflammation, Chronic Active         |                                                                          |             
      Necrosis, Coagulative                |                                                                          |             
      Pigmentation                         |    1  1  1  1  1  1  1  1     1  1     1              1  1  1            |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Depletion Lymphoid                   |                               3        2                          3      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   9                                                               
NTP Experiment-Test: 05061-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 09:33:30  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 0| 7| 4| 7| 7| 7| 7| 7| 7| 6| 6|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 5| 3| 3| 3| 3| 3| 0| 5| 2|             
                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 6| 3| 5| 3| 4| 4| 3| 4| 8| 3| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    UNTREATE                               | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
    D 71UF                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Fibrosis                             |                                                                1         |             
      Hematopoietic Cell Proliferation     |                               3                                          |             
      Hyperplasia, Lymphoid                |       1        1  2  2  2  2                 1           2  2  1         |             
      Inflammation, Chronic                |                                                                1         |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  M  +  +  +  M  +  +  +  M|             
      Angiectasis                          |             2                                                            |             
      Cyst                                 | 1  1     1  1  1     1                                1  1               |             
      Depletion Lymphoid                   |                                                                   4      |             
      Hyperplasia, Lymphoid                |                            2                 2                           |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  +  +  M  M  +  +  M  M  M  M  +  M  M  M  +  +  +  M  +  M  M  M  +  +|             
      Hyperplasia                          |                                                          1              2|             
      Inflammation, Chronic                |                                                                         1|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic Active                  |                                                                          |             
      Subcutaneous Tissue, Mineralization  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                      +   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Thalamus, Mineralization             | 1        1  1              1     1                    1     1  1  1  1   |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                           2                              |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Chronic Active         |                                                    1                     |             
      Leukocytosis                         |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  | 1        1        1     1  1     1  1  1     1     1     1        1      |             
      Glands, Inflammation, Acute          |                                                 1                        |             
      Nasolacrimal Duct, Hyperplasia       |                   3                                                      |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                         +|             
                                            __________________________________________________________________________|             
   Eye                                     |                   +                                                      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  10                                                               
NTP Experiment-Test: 05061-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 09:33:30  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 0| 7| 4| 7| 7| 7| 7| 7| 7| 6| 6|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 5| 3| 3| 3| 3| 3| 0| 5| 2|             
                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 6| 3| 5| 3| 4| 4| 3| 4| 8| 3| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    UNTREATE                               | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
    D 71UF                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                   +                                                      |             
      Inflammation, Chronic                |                   1                                                      |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Glomerulosclerosis                   |                                           4                              |             
      Hydronephrosis                       |                                                                          |             
      Infarct                              |                2                                                         |             
      Inflammation, Chronic                | 1  1  1  1     2  1  1  1  1     1  1  2     1  1  1     1  1  2  1     1|             
      Proximal Convoluted Renal Tubule,    |                                                                          |             
           Degeneration, Hyaline           |                               2                                          |             
      Renal Tubule, Casts Protein          |                                     1                                    |             
      Renal Tubule, Regeneration           |                                     1                                    |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                   3      |             
      Inflammation, Chronic                |                                                 1                        |             
      Inflammation, Chronic Active         | 1  1  1  1  1  2  2  1     1  1  1  1  1     1     1  1  1  1  1  1     1|             
      Submucosa, Proliferation             |                                           2                              |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  11                                                               
NTP Experiment-Test: 05061-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 09:33:30  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7| 7| 4| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 5| 3| 3| 5| 3| 3| 3| 0| 0|                                            |            |
                                           | 3| 5| 3| 3| 7| 4| 4| 4| 6| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    UNTREATE                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |      L     |
    D 71UF                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  +  M  +                                             |  59        |
      Autolysis                            |                                                                          |      3  3.3|
      Inflammation, Chronic                |                                                                          |      1  1.0|
      Inflammation, Chronic Active         |          1                                                               |      6  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Autolysis                            |                                                                          |      3  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Autolysis                            |                                                                          |      2  2.0|
      Peyer's Patch, Epithelium,           |                                                                          |            |
          Proliferation                    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Autolysis                            |                                                                          |      4  2.8|
      Peyer's Patch, Hyperplasia           |                   2                                                      |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  M  +  +  +                                             |  58        |
      Autolysis                            |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  57        |
      Autolysis                            |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Autolysis                            |                                                                          |      2  3.5|
      Peyer's Patch, Hyperplasia           | 2                                                                        |      4  1.8|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Autolysis                            |                                                                          |      2  1.5|
      Fatty Change                         |       1                                                                  |      3  1.3|
      Hematopoietic Cell Proliferation     |                         3  2                                             |      3  2.3|
      Inflammation, Chronic Active         | 1  1        1  1  1  1                                                   |     36  1.0|
      Necrosis, Coagulative                |    1           1     1                                                   |     16  1.1|
                                            __________________________________________________________________________|____________|
   Mesentery                               |          +              +                                                |   6        |
      Inflammation, Chronic Active         |          1              4                                                |      3  2.7|
      Mineralization                       |          1                                                               |      1  1.0|
      Necrosis, Coagulative                |                                                                          |      1  3.0|
      Pigmentation                         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cytoplasmic Alteration               |                                                                          |      3  1.0|
      Inflammation, Chronic                |             1                                                            |      5  1.0|
      Inflammation, Chronic Active         | 1     1  1        1     2  1                                             |     25  1.2|
      Vacuolization Cytoplasmic            | 1           2                                                            |     20  1.4|
      Duct, Dilatation                     |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  59        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  12                                                               
NTP Experiment-Test: 05061-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 09:33:30  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7| 7| 4| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 5| 3| 3| 5| 3| 3| 3| 0| 0|                                            |            |
                                           | 3| 5| 3| 3| 7| 4| 4| 4| 6| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    UNTREATE                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |      L     |
    D 71UF                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Sublingual Gland, Inflammation,      |                                                                          |            |
          Chronic                          |                1                                                         |      1  1.0|
      Submandibular Gland, Inflammation,   |                                                                          |            |
           Chronic                         | 1     1     1  1  1  1  1  2                                             |     47  1.1|
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Acanthosis                           |       2           2                                                      |      9  1.7|
      Hyperkeratosis                       |                   2                                                      |     10  1.4|
      Inflammation, Chronic Active         | 1                 2                                                      |      7  1.4|
      Ulcer                                |                   2                                                      |      2  2.0|
      Ulcer, Multiple                      |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Autolysis                            |                                                                          |      2  2.0|
      Inflammation, Chronic                |    1                                                                     |      2  1.0|
      Inflammation, Chronic Active         |       1  1     1  2  1                                                   |     21  1.1|
      Mineralization                       |                         1                                                |      1  1.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
      Abscess                              |                                                                          |      1  2.0|
      Dysplasia                            |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cardiomyopathy                       |                                                                          |      2  1.0|
      Inflammation, Chronic                |                                                                          |      9  1.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Angiectasis                          |                                                                          |      2  1.5|
      Hematopoietic Cell Proliferation     |                                                                          |      1  1.0|
      Inflammation, Chronic Active         |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +     +  +     +  +  +  +  +                                             |  49        |
      Hyperplasia                          |       1                                                                  |      3  1.3|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  +  M  +  +  +  +  +  +  +                                             |  43        |
      Cyst                                 |                            2                                             |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  51        |
      Pars Distalis, Angiectasis           |                                                                          |      1  2.0|
      Pars Distalis, Cyst                  |                                                                          |      3  1.0|
      Pars Distalis, Hyperplasia           |       2        2     3                                                   |      8  1.8|
      Pars Distalis, Pigmentation          |                                                                          |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  13                                                               
NTP Experiment-Test: 05061-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 09:33:30  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7| 7| 4| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 5| 3| 3| 5| 3| 3| 3| 0| 0|                                            |            |
                                           | 3| 5| 3| 3| 7| 4| 4| 4| 6| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    UNTREATE                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |      L     |
    D 71UF                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      C-Cell, Hyperplasia                  |                                                                          |      1  1.0|
      Follicle, Cyst                       | 2                                                                        |      2  2.0|
      Follicular Cell, Hyperplasia         |                                                                          |      3  1.3|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Angiectasis                          |                                                                          |      2  2.0|
      Cyst                                 | 3     2     4                                                            |     13  2.4|
      Cyst, Multiple                       |                                                                          |      1  2.0|
      Inflammation, Acute, Necrotizing     |                                                                          |      1  2.0|
      Pigmentation                         |                                                                          |      1  3.0|
      Periovarian Tissue, Cyst             |                                                                          |      1  4.0|
      Periovarian Tissue, Inflammation,    |                                                                          |            |
           Chronic                         |                                                                          |      2  1.0|
      Periovarian Tissue, Inflammation,    |                                                                          |            |
           Chronic Active                  | 3              1  1     3  1                                             |     29  1.2|
      Periovarian Tissue, Mineralization   |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Hydrometra                           |    2        1                                                            |     22  2.5|
      Inflammation, Chronic Active         | 2                 2     2                                                |      4  2.0|
      Endometrium, Hyperplasia             | 3     2  2     2  2  3  2  2                                             |     44  2.0|
      Epithelium, Metaplasia, Squamous     | 1                 1                                                      |      2  1.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Myelofibrosis                        |                                                                          |      2  1.0|
      Myeloid Cell, Sternal, Hyperplasia   |                            4                                             |      2  3.5|
      Sternal, Myelofibrosis               | 3     3  2     3  2  2     1                                             |     38  1.9|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                         +                                                |   7        |
      Lumbar, Hyperplasia, Lymphoid        |                                                                          |      1  2.0|
      Lumbar, Inflammation, Acute          |                                                                          |      1  2.0|
      Mediastinal, Inflammation, Chronic   |                                                                          |            |
          Active                           |                         3                                                |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  M  +  M  +  M  +  +  +  +                                             |  38        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  14                                                               
NTP Experiment-Test: 05061-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 09:33:30  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7| 7| 4| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 5| 3| 3| 5| 3| 3| 3| 0| 0|                                            |            |
                                           | 3| 5| 3| 3| 7| 4| 4| 4| 6| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    UNTREATE                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |      L     |
    D 71UF                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Congestion                           |                         1                                                |      1  1.0|
      Hyperplasia, Lymphoid                |                      3  3                                                |      3  2.7|
      Hyperplasia, Plasma Cell             |                      3                                                   |      1  3.0|
      Pigmentation                         |             1     1        2                                             |      3  1.3|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  56        |
      Angiectasis                          |                      1  2                                                |      7  1.4|
      Depletion Lymphoid                   |                                                                          |      2  2.5|
      Hyperplasia, Lymphoid                |                         4                                                |      2  4.0|
      Infiltration Cellular, Histiocyte    | 1  1  1  1  1  1  1  1     1                                             |     36  1.0|
      Inflammation, Chronic Active         |                            3                                             |      1  3.0|
      Necrosis, Coagulative                |                                                                          |      1  2.0|
      Pigmentation                         | 1  1  1  1     1  1  1     1                                             |     34  1.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Autolysis                            |                                                                          |      1  2.0|
      Depletion Lymphoid                   |                            3                                             |      4  2.8|
      Fibrosis                             |                                                                          |      1  1.0|
      Hematopoietic Cell Proliferation     |                         2  4                                             |      6  2.8|
      Hyperplasia, Lymphoid                |       2  1     3                                                         |     15  1.8|
      Inflammation, Chronic                |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  M  +  +  +  +  M  M  M                                             |  49        |
      Angiectasis                          |                                                                          |      1  2.0|
      Cyst                                 |             1                                                            |     21  1.0|
      Depletion Lymphoid                   |                                                                          |      4  3.0|
      Hyperplasia, Lymphoid                |                                                                          |      3  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  M  M  +  M  M  +  M  +                                             |  35        |
      Hyperplasia                          |                                                                          |      2  1.5|
      Inflammation, Chronic                |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Acanthosis                           |                                                                          |      1  2.0|
      Inflammation, Acute                  |                                                                          |      1  3.0|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Chronic Active                  |                                                                          |      1  1.0|
      Subcutaneous Tissue, Mineralization  |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  M  +  +  M  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   4        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  15                                                               
NTP Experiment-Test: 05061-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 09:33:30  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7| 7| 4| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 5| 3| 3| 5| 3| 3| 3| 0| 0|                                            |            |
                                           | 3| 5| 3| 3| 7| 4| 4| 4| 6| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    UNTREATE                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |      L     |
    D 71UF                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Thalamus, Mineralization             |       1  1  1  1           1                                             |     24  1.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Congestion                           |                                                                          |      1  2.0|
      Hemorrhage                           |          1                                                               |      4  1.0|
      Inflammation, Chronic Active         |                1                                                         |      3  1.3|
      Leukocytosis                         |                         3                                                |      1  3.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Inflammation, Acute                  |          1        1     1                                                |     21  1.0|
      Glands, Inflammation, Acute          |                                                                          |      2  1.0|
      Nasolacrimal Duct, Hyperplasia       |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
      Inflammation, Chronic                |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Glomerulosclerosis                   |                            2                                             |      2  3.0|
      Hydronephrosis                       |                                                                          |      1  1.0|
      Infarct                              |                                                                          |      1  2.0|
      Inflammation, Chronic                | 1  1  1  2  1  1  1  1  1  1                                             |     53  1.1|
      Proximal Convoluted Renal Tubule,    |                                                                          |            |
           Degeneration, Hyaline           |                                                                          |      1  2.0|
      Renal Tubule, Casts Protein          |                                                                          |      1  1.0|
      Renal Tubule, Regeneration           |                                                                          |      3  1.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Autolysis                            |                                                                          |      3  3.0|
      Inflammation, Chronic                |    1        1                                                            |      7  1.0|
      Inflammation, Chronic Active         | 2     1  1     1  1  1  1  1                                             |     42  1.1|
      Submucosa, Proliferation             |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  16                                                               
NTP Experiment-Test: 05061-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 09:33:30  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 3| 7| 7| 7| 7| 6| 7| 7| 7| 4| 7| 7| 7| 7| 7| 4| 7| 7| 4| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 5| 7| 3| 3| 3| 3| 5| 3| 3| 3| 5| 1| 3| 3| 3| 3| 5| 3| 3| 5| 1| 1|             
                                           | 0| 0| 0| 7| 2| 0| 0| 0| 0| 2| 0| 0| 0| 5| 3| 0| 0| 0| 0| 7| 0| 0| 5| 6| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    1.0%                                   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    71LF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |          3                 2                                             |             
      Inflammation, Chronic Active         |                                                    1                 2   |             
      Epithelium, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                            1                                             |             
      Inflammation, Acute                  |                                                                          |             
      Peyer's Patch, Hyperplasia           |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                            1                                             |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |          3                                                               |             
      Peyer's Patch, Hyperplasia           |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                         1|             
      Autolysis                            |          2                 1                                             |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |          2                 3                                             |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |          3                 4                                             |             
      Inflammation, Acute                  |                                                                          |             
      Peyer's Patch, Hyperplasia           |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |       1              1                                                   |             
      Clear Cell Focus                     |                                           1        1                    1|             
      Eosinophilic Focus                   |    2                    1                                                |             
      Fatty Change                         |                               1                                          |             
      Hematopoietic Cell Proliferation     |                            2                                         1   |             
      Inflammation, Acute                  |                                        1                          1      |             
      Inflammation, Chronic Active         | 1  1              1  1  1     1  1  1        1     1        1  1     1  1|             
      Mixed Cell Focus                     |                                           1                              |             
      Necrosis, Coagulative                | 1  1  1           2     1              1     1        2     1     1      |             
      Pigmentation                         | 1     1     1  1  1  1  1  1  1     1  1  1  1     1     1  1  1  1  1  1|             
      Bile Duct, Hyperplasia, Focal        |                                                                          |             
      Bile Duct, Hyperplasia               |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                            +  +                                      +   |             
      Fibrosis                             |                               1                                          |             
      Inflammation, Chronic Active         |                            2                                         3   |             
      Necrosis, Coagulative                |                               2                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                       2                  |             
      Cytoplasmic Alteration               |                                                                          |             
      Inflammation, Chronic Active         | 1           1        1     2                 1        2        1     1  1|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  17                                                               
NTP Experiment-Test: 05061-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 09:33:30  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 3| 7| 7| 7| 7| 6| 7| 7| 7| 4| 7| 7| 7| 7| 7| 4| 7| 7| 4| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 5| 7| 3| 3| 3| 3| 5| 3| 3| 3| 5| 1| 3| 3| 3| 3| 5| 3| 3| 5| 1| 1|             
                                           | 0| 0| 0| 7| 2| 0| 0| 0| 0| 2| 0| 0| 0| 5| 3| 0| 0| 0| 0| 7| 0| 0| 5| 6| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    1.0%                                   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    71LF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Inflammation                         |                   1                                                      |             
      Vacuolization Cytoplasmic            | 1  1  1                             1     1     1     3        1         |             
      Duct, Dilatation                     |                                                       2                  |             
      Duct, Hyperplasia                    |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                              1                           |             
      Sublingual Gland, Inflammation,      |                                                                          |             
          Chronic                          |                                                                          |             
      Submandibular Gland, Inflammation,   |                                                                          |             
           Chronic                         | 1                             1  1        1     1  1  1        1     1  1|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |    2                       1  2        1     1  2                        |             
      Erosion                              |                                                                          |             
      Hyperkeratosis                       |    2                       2  2        1     1  2                        |             
      Hyperplasia, Basal Cell              |    2                       1                    1                        |             
      Inflammation, Chronic Active         |    2                          1           1     1  1                     |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  M  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         | 1              1     1  1     1     1        1     2  1        1         |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                               1                                      2   |             
      Mineralization                       |          1                                                               |             
      Thrombosis                           |          2                                                               |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |    2                                                                     |             
      Hematopoietic Cell Proliferation     |                                                                      1   |             
      Hyperplasia                          |                               1                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Vacuolization Cytoplasmic            |                                                                      1   |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +     +  +|             
      Hyperplasia                          |                                                                      1   |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +     +  +  +  +  +  +  M  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  I  +  +  M  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +|             
      Pars Distalis, Hyperplasia           |    1              2  1  1     1  2  1     1  1                          2|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  18                                                               
NTP Experiment-Test: 05061-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 09:33:30  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 3| 7| 7| 7| 7| 6| 7| 7| 7| 4| 7| 7| 7| 7| 7| 4| 7| 7| 4| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 5| 7| 3| 3| 3| 3| 5| 3| 3| 3| 5| 1| 3| 3| 3| 3| 5| 3| 3| 5| 1| 1|             
                                           | 0| 0| 0| 7| 2| 0| 0| 0| 0| 2| 0| 0| 0| 5| 3| 0| 0| 0| 0| 7| 0| 0| 5| 6| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    1.0%                                   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    71LF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      C-Cell, Hyperplasia                  |                                                                          |             
      Follicular Cell, Hyperplasia         |                1  2     2        1  1        2  2     1              1  1|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Abscess                              |                   3        4                                             |             
      Angiectasis                          |                                                       2        2         |             
      Cyst                                 |    2     1           4           1     4                    2            |             
      Cyst, Multiple                       |       2                 2                                                |             
      Hemorrhage                           |                                                                          |             
      Mineralization                       |                                                                          |             
      Periovarian Tissue, Cyst             |                                                          1               |             
      Periovarian Tissue, Inflammation,    |                                                                          |             
           Chronic Active                  | 1  1     1        3  2  1     1  1           1     1                    1|             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                 2                        |             
      Hydrometra                           |             3                                                            |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic Active         |                   1        2                                             |             
      Endometrium, Hyperplasia             | 2  2  2        2  2  1  1  1  2  2  2        2  1  1        2           2|             
      Epithelium, Metaplasia, Squamous     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Myelofibrosis                        |                1                                               1         |             
      Myeloid Cell, Sternal, Hyperplasia   |                                                                          |             
      Sternal, Myelofibrosis               | 2  3  2           2  2  3  2  2  2  1     1  2  2  2        2           1|             
                                            __________________________________________________________________________|             
   Lymph Node                              |                            +  +     +              +                     |             
      Pancreatic, Hyperplasia, Lymphoid    |                                     1                                    |             
      Renal, Hyperplasia, Plasma Cell      |                            3                                             |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  I  +  +  +  +  +  +  +  +|             
      Depletion Lymphoid                   |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Pigmentation                         |                                                             2            |             
      Sinus, Ectasia                       |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                              1                           |             
      Depletion Lymphoid                   |                                                                          |             
      Hemorrhage                           |                      1                                                   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  19                                                               
NTP Experiment-Test: 05061-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 09:33:30  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 3| 7| 7| 7| 7| 6| 7| 7| 7| 4| 7| 7| 7| 7| 7| 4| 7| 7| 4| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 5| 7| 3| 3| 3| 3| 5| 3| 3| 3| 5| 1| 3| 3| 3| 3| 5| 3| 3| 5| 1| 1|             
                                           | 0| 0| 0| 7| 2| 0| 0| 0| 0| 2| 0| 0| 0| 5| 3| 0| 0| 0| 0| 7| 0| 0| 5| 6| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    1.0%                                   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    71LF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hyperplasia, Lymphoid                |                      3  3                                               1|             
      Infiltration Cellular, Histiocyte    | 1  1  1  1                       1        1  1     1  1     1  1         |             
      Inflammation, Chronic Active         |                                                                          |             
      Mineralization                       |                                                                          |             
      Pigmentation                         | 1  1  1  1                       1        1  1     1  1     1  1         |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Depletion Lymphoid                   |                                                             2            |             
      Hematopoietic Cell Proliferation     |                            3        1                 3     3        1   |             
      Hyperplasia, Lymphoid                | 1  1                          2                    1           2        1|             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  M  +  +  +  +  +  M  +  +  +  +  M  +  M  M  +  +  +  +  +  +  +|             
      Cyst                                 | 1  1              1  1           1           1        1     1        1  1|             
      Depletion Lymphoid                   |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  M  +  M  M  M  M  +  M  +  +  M  M  M  M  +  M  +  +  +  +|             
      Hyperplasia                          | 1        1                                                           2   |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Subcutaneous Tissue, Cyst Epithelial |                                                                          |             
          Inclusion                        |                                                                          |             
      Subcutaneous Tissue, Fibrosis        |                                                                          |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic Active                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +     +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  M  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                      +   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Perivascular, Inflammation, Chronic  |                                                                          |             
      Thalamus, Mineralization             |                   1           1  1              1     1              1   |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |          2  1                                                            |             
      Inflammation, Chronic Active         |                                                                          |             
      Leukocytosis                         |                                                                          |             
      Pleura, Inflammation, Acute          |                            1                                             |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Inflammation, Acute                  |    1                                               1                     |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Acute                           | 1                                                                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  20                                                               
NTP Experiment-Test: 05061-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 09:33:30  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 3| 7| 7| 7| 7| 6| 7| 7| 7| 4| 7| 7| 7| 7| 7| 4| 7| 7| 4| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 5| 7| 3| 3| 3| 3| 5| 3| 3| 3| 5| 1| 3| 3| 3| 3| 5| 3| 3| 5| 1| 1|             
                                           | 0| 0| 0| 7| 2| 0| 0| 0| 0| 2| 0| 0| 0| 5| 3| 0| 0| 0| 0| 7| 0| 0| 5| 6| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    1.0%                                   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    71LF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +           +                                                            |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  M  +  +|             
      Glomerulosclerosis                   |                                                       1                  |             
      Hydronephrosis                       |                                                                          |             
      Inflammation, Chronic                | 1  2  1  1  1  1     1  1  2  1  1  1     1  1  1  1  2     1  1     1  1|             
      Metaplasia, Osseous                  |          1                                                               |             
      Pelvis, Transitional Epithelium,     |                                                                          |             
           Hyperplasia                     |                                                                          |             
      Renal Tubule, Atrophy                |                                                       1                  |             
      Renal Tubule, Pigmentation           | 1  1  1  1     1     1  1     1  1  1     1  1  1  1  2     1  1     2  1|             
      Renal Tubule, Regeneration           |                                                       1                 1|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |          3                                                               |             
      Inflammation, Chronic                |                                                          1        1      |             
      Inflammation, Chronic Active         | 1  1  1  1     1     1  1  1  1  1  1        1  1  2  1     1  1     1  1|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  21                                                               
NTP Experiment-Test: 05061-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 09:33:30  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 4| 4| 4| 7| 7| 7| 7| 7| 7| 5| 2| 7| 7| 6| 6| 4| 7| 4| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 8| 5| 5| 5| 3| 3| 2| 3| 3| 0| 0| 0| 3| 3| 7| 7| 4| 3| 5| 3| 3| 3|             
                                           | 0| 0| 0| 7| 5| 7| 7| 0| 0| 7| 0| 0| 6| 3| 2| 3| 0| 9| 1| 2| 3| 5| 3| 3| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    1.0%                                   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    71LF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Inflammation, Chronic Active         |          1                                   1                       1   |             
      Epithelium, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Inflammation, Acute                  |          2                                                               |             
      Peyer's Patch, Hyperplasia           |                                              1                           |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Peyer's Patch, Hyperplasia           |       1                          2                                       |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Autolysis                            |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Inflammation, Acute                  |          1                                                               |             
      Peyer's Patch, Hyperplasia           |       1                       1              1                           |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |             1              1                                             |             
      Clear Cell Focus                     |                      1           1           1        3                  |             
      Eosinophilic Focus                   |                                              1                       2   |             
      Fatty Change                         |       1                                                     1            |             
      Hematopoietic Cell Proliferation     |          2                                         1                    3|             
      Inflammation, Acute                  |             1                                                  1         |             
      Inflammation, Chronic Active         |    2     1     1  1     1     1     1           1     1              1   |             
      Mixed Cell Focus                     |          4                                                               |             
      Necrosis, Coagulative                |    2  2     1  1              1     1  3  1  1     2           1  1     3|             
      Pigmentation                         | 1  1  1  1  1  1  1  1  1  2  1  1  1  1     1  1  1  1  1  1  1  1  1  1|             
      Bile Duct, Hyperplasia, Focal        |                                                                          |             
      Bile Duct, Hyperplasia               |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                            +                       +  +           +     +|             
      Fibrosis                             |                                                    2              1      |             
      Inflammation, Chronic Active         |                                                    2                    3|             
      Necrosis, Coagulative                |                                                    2              2      |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Cytoplasmic Alteration               |                                                             1            |             
      Inflammation, Chronic Active         | 1  1  1  2           1           1           1  1     1           1  1  2|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  22                                                               
NTP Experiment-Test: 05061-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 09:33:30  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 4| 4| 4| 7| 7| 7| 7| 7| 7| 5| 2| 7| 7| 6| 6| 4| 7| 4| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 8| 5| 5| 5| 3| 3| 2| 3| 3| 0| 0| 0| 3| 3| 7| 7| 4| 3| 5| 3| 3| 3|             
                                           | 0| 0| 0| 7| 5| 7| 7| 0| 0| 7| 0| 0| 6| 3| 2| 3| 0| 9| 1| 2| 3| 5| 3| 3| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    1.0%                                   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    71LF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Inflammation                         |                                                                          |             
      Vacuolization Cytoplasmic            |                                                    3                     |             
      Duct, Dilatation                     |                                                                          |             
      Duct, Hyperplasia                    |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Sublingual Gland, Inflammation,      |                                                                          |             
          Chronic                          |                                                 1                    2   |             
      Submandibular Gland, Inflammation,   |                                                                          |             
           Chronic                         | 1  2  1  1           1  2  1  1     2        2  2     1  1  1     1  2   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           | 1  1                                3  2  2  2        2  1               |             
      Erosion                              |                                           2                              |             
      Hyperkeratosis                       | 1  1                                   2  1  1        1  1               |             
      Hyperplasia, Basal Cell              | 1                                      2              2                  |             
      Inflammation, Chronic Active         | 1     2     1                          2     1        2                  |             
      Ulcer                                |                                                       2                  |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         |       1                 1           1           1                 1  1   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                         1                          1                     |             
      Mineralization                       |                                                                          |             
      Thrombosis                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hematopoietic Cell Proliferation     |          2                                                              2|             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic Active         |          3                                                               |             
      Vacuolization Cytoplasmic            |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                                         2|             
      Hyperplasia                          |                                                       2                  |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +           +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  M  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  M  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  I  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Hyperplasia           | 1                    1  1  2  1  1                 1                     |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |    2                                                                 1   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  23                                                               
NTP Experiment-Test: 05061-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 09:33:30  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 4| 4| 4| 7| 7| 7| 7| 7| 7| 5| 2| 7| 7| 6| 6| 4| 7| 4| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 8| 5| 5| 5| 3| 3| 2| 3| 3| 0| 0| 0| 3| 3| 7| 7| 4| 3| 5| 3| 3| 3|             
                                           | 0| 0| 0| 7| 5| 7| 7| 0| 0| 7| 0| 0| 6| 3| 2| 3| 0| 9| 1| 2| 3| 5| 3| 3| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    1.0%                                   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    71LF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      C-Cell, Hyperplasia                  |                                                                          |             
      Follicular Cell, Hyperplasia         |    1  1                       1  1  1                 1     1     1      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |                                           M                              |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  M  M  M  +  +  +  +  +  +  +  +  +  +     +  +  +  M  +  +  +|             
      Abscess                              |          4                                                               |             
      Angiectasis                          |                         1  1                                             |             
      Cyst                                 |                            3     4  3        2                           |             
      Cyst, Multiple                       |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Mineralization                       |                            1                          1                  |             
      Periovarian Tissue, Cyst             |                                                          2               |             
      Periovarian Tissue, Inflammation,    |                                                                          |             
           Chronic Active                  | 1  2  1              1  1     1  1           1  1                 1     2|             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                      2                                                   |             
      Hydrometra                           |       3                                               2                  |             
      Inflammation, Acute                  |                                                                         2|             
      Inflammation, Chronic Active         | 2     2  1                                                               |             
      Endometrium, Hyperplasia             | 3     2  3           2  2     3     1     2  3  3  1  2     3     2     1|             
      Epithelium, Metaplasia, Squamous     |          2                                                               |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Myelofibrosis                        |                         2                          1                     |             
      Myeloid Cell, Sternal, Hyperplasia   |                                                                          |             
      Sternal, Myelofibrosis               | 2     2              2        2  2  2  1        2     1     2     2  1   |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +     +           +                             +  +                  |             
      Pancreatic, Hyperplasia, Lymphoid    |                                                                          |             
      Renal, Hyperplasia, Plasma Cell      |          3                                                               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Depletion Lymphoid                   |                                                    4                     |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Pigmentation                         |                                                    2                     |             
      Sinus, Ectasia                       |                      3                                                   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 1                       2                                            2   |             
      Depletion Lymphoid                   |                                                    3                     |             
      Hemorrhage                           |                                                                         4|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  24                                                               
NTP Experiment-Test: 05061-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 09:33:30  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 4| 4| 4| 7| 7| 7| 7| 7| 7| 5| 2| 7| 7| 6| 6| 4| 7| 4| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 8| 5| 5| 5| 3| 3| 2| 3| 3| 0| 0| 0| 3| 3| 7| 7| 4| 3| 5| 3| 3| 3|             
                                           | 0| 0| 0| 7| 5| 7| 7| 0| 0| 7| 0| 0| 6| 3| 2| 3| 0| 9| 1| 2| 3| 5| 3| 3| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    1.0%                                   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    71LF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hyperplasia, Lymphoid                |    3                       3     2                                       |             
      Infiltration Cellular, Histiocyte    | 1     1  1                    1  1  1           1  1              1  1   |             
      Inflammation, Chronic Active         |          1                                                              4|             
      Mineralization                       |                                                                          |             
      Pigmentation                         | 1     1  1                    1  1  1           1  1              1  1   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Depletion Lymphoid                   |                                                    3                     |             
      Hematopoietic Cell Proliferation     |          4                                      2  3  2              2  4|             
      Hyperplasia, Lymphoid                | 2  1                 1  2  3                                      2      |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  M  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  M  +  +  +  +  +  +  M|             
      Cyst                                 |       1              1                       1  1                 1      |             
      Depletion Lymphoid                   |                                        3                                 |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  +  +  +  +  +  +  M  +  +  +  M  M  M  +  M  M  M  +  +  +  M  +  +|             
      Hyperplasia                          |       1                    1  1                                         1|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Subcutaneous Tissue, Cyst Epithelial |                                                                          |             
          Inclusion                        |                            X                                             |             
      Subcutaneous Tissue, Fibrosis        |                         2                                                |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic Active                  |                         1                                               1|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  M  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +     +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                            +                                             |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Perivascular, Inflammation, Chronic  |                         1                                                |             
      Thalamus, Mineralization             | 1                          1  1     1  1                 1  1            |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                    1  1                  |             
      Inflammation, Chronic Active         |                         1                 1     1                    2   |             
      Leukocytosis                         |                                                                         3|             
      Pleura, Inflammation, Acute          |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |       1                       1     1  1     1                           |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Acute                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  25                                                               
NTP Experiment-Test: 05061-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 09:33:30  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 4| 4| 4| 7| 7| 7| 7| 7| 7| 5| 2| 7| 7| 6| 6| 4| 7| 4| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 8| 5| 5| 5| 3| 3| 2| 3| 3| 0| 0| 0| 3| 3| 7| 7| 4| 3| 5| 3| 3| 3|             
                                           | 0| 0| 0| 7| 5| 7| 7| 0| 0| 7| 0| 0| 6| 3| 2| 3| 0| 9| 1| 2| 3| 5| 3| 3| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    1.0%                                   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    71LF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Glomerulosclerosis                   | 1                          3                                             |             
      Hydronephrosis                       |                                           2                              |             
      Inflammation, Chronic                |       1  1  1  1  1  1  2  1  1  1  1  1     1  2  1     2  1     1  2   |             
      Metaplasia, Osseous                  |    1                                                                     |             
      Pelvis, Transitional Epithelium,     |                                                                          |             
           Hyperplasia                     |                                                                          |             
      Renal Tubule, Atrophy                |                                                                          |             
      Renal Tubule, Pigmentation           | 1  1  1              1  1  1  1  1  1  1     1  1  1  1     1     1  1  1|             
      Renal Tubule, Regeneration           |                                              1  1                        |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Inflammation, Chronic                |             1  1  1                                            1         |             
      Inflammation, Chronic Active         | 1  1  1  1              1  1  1     1  1     1  1  1  1  1  1     1  3  1|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  26                                                               
NTP Experiment-Test: 05061-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 09:33:30  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 4| 7| 4| 4| 7| 7| 5|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 5| 1| 5| 5| 3| 3| 5|                                            |            |
                                           | 3| 3| 3| 7| 3| 5| 7| 3| 3| 5|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      A     |
    1.0%                                   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |      L     |
    71LF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  M                                             |  55        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +                                             |  57        |
      Autolysis                            |                                                                          |      2  2.5|
      Inflammation, Chronic Active         |                            1                                             |      6  1.2|
      Epithelium, Hyperplasia              |             2                                                            |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Autolysis                            |                                                                          |      1  1.0|
      Inflammation, Acute                  |                                                                          |      1  2.0|
      Peyer's Patch, Hyperplasia           |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Autolysis                            |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Autolysis                            |                                                                          |      1  3.0|
      Peyer's Patch, Hyperplasia           |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Angiectasis                          |                                                                          |      1  1.0|
      Autolysis                            |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Autolysis                            |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Autolysis                            |                                                                          |      2  3.5|
      Inflammation, Acute                  |                                                                          |      1  1.0|
      Peyer's Patch, Hyperplasia           |                                                                          |      3  1.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Basophilic Focus                     |                            2                                             |      5  1.2|
      Clear Cell Focus                     |       1              1     1                                             |     10  1.2|
      Eosinophilic Focus                   |                                                                          |      4  1.5|
      Fatty Change                         |                2                                                         |      4  1.3|
      Hematopoietic Cell Proliferation     |                            2                                             |      6  1.8|
      Inflammation, Acute                  |          1                                                               |      5  1.0|
      Inflammation, Chronic Active         | 1              1  1        3                                             |     28  1.1|
      Mixed Cell Focus                     |                                                                          |      2  2.5|
      Necrosis, Coagulative                |          1     1  1                                                      |     26  1.3|
      Pigmentation                         | 1  1  1  1  2  1  1  1  1  2                                             |     54  1.1|
      Bile Duct, Hyperplasia, Focal        |          1                                                               |      1  1.0|
      Bile Duct, Hyperplasia               |             1                                                            |      1  1.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                         +                                                |   9        |
      Fibrosis                             |                         1                                                |      4  1.3|
      Inflammation, Chronic Active         |                         1                                                |      5  2.2|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  27                                                               
NTP Experiment-Test: 05061-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 09:33:30  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 4| 7| 4| 4| 7| 7| 5|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 5| 1| 5| 5| 3| 3| 5|                                            |            |
                                           | 3| 3| 3| 7| 3| 5| 7| 3| 3| 5|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      A     |
    1.0%                                   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |      L     |
    71LF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Necrosis, Coagulative                |                                                                          |      3  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Atrophy                              |                                                                          |      1  2.0|
      Cytoplasmic Alteration               |                                                                          |      1  1.0|
      Inflammation, Chronic Active         |       2                 1  2                                             |     24  1.3|
      Inflammation                         |                                                                          |      1  1.0|
      Vacuolization Cytoplasmic            | 2                    1  1  1                                             |     13  1.4|
      Duct, Dilatation                     |                                                                          |      1  2.0|
      Duct, Hyperplasia                    |             2                                                            |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Inflammation, Chronic                |                                                                          |      1  1.0|
      Sublingual Gland, Inflammation,      |                                                                          |            |
          Chronic                          |                                                                          |      2  1.5|
      Submandibular Gland, Inflammation,   |                                                                          |            |
           Chronic                         | 1  1  1     1           1  1                                             |     32  1.2|
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Acanthosis                           | 1           2                                                            |     16  1.6|
      Erosion                              |                                                                          |      1  2.0|
      Hyperkeratosis                       | 1           2  1                                                         |     16  1.4|
      Hyperplasia, Basal Cell              | 1                                                                        |      7  1.4|
      Inflammation, Chronic Active         |                                                                          |     11  1.4|
      Ulcer                                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Inflammation, Chronic                |       1                                                                  |      1  1.0|
      Inflammation, Chronic Active         |                      1  1  1                                             |     19  1.1|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Inflammation, Chronic                |       1                    1                                             |      6  1.2|
      Mineralization                       |                                                                          |      1  1.0|
      Thrombosis                           |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  M  +  +  +  +  +                                             |  59        |
      Cyst                                 |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     |                                                                          |      3  1.7|
      Hyperplasia                          |                                                                          |      1  1.0|
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
      Vacuolization Cytoplasmic            |                                                                          |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  28                                                               
NTP Experiment-Test: 05061-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 09:33:30  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 4| 7| 4| 4| 7| 7| 5|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 5| 1| 5| 5| 3| 3| 5|                                            |            |
                                           | 3| 3| 3| 7| 3| 5| 7| 3| 3| 5|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      A     |
    1.0%                                   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |      L     |
    71LF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  M  +  +  +  +  +                                             |  59        |
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +     +        +  +  +                                             |  50        |
      Hyperplasia                          |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  55        |
      Pars Distalis, Hyperplasia           |    1  2     1        1  1                                                |     22  1.2|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Inflammation, Chronic Active         |                                                                          |      2  1.5|
      C-Cell, Hyperplasia                  |             1                                                            |      1  1.0|
      Follicular Cell, Hyperplasia         |       1                                                                  |     19  1.2|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |             +                                                            |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  M  +  M  M  +  +  +                                             |  51        |
      Abscess                              |                                                                          |      3  3.7|
      Angiectasis                          |                                                                          |      4  1.5|
      Cyst                                 |    2                       2                                             |     12  2.5|
      Cyst, Multiple                       | 1                                                                        |      3  1.7|
      Hemorrhage                           |                            2                                             |      1  2.0|
      Mineralization                       |                                                                          |      2  1.0|
      Periovarian Tissue, Cyst             |                                                                          |      2  1.5|
      Periovarian Tissue, Inflammation,    |                                                                          |            |
           Chronic Active                  |                      2  1                                                |     24  1.3|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Fibrosis                             |                                                                          |      2  2.0|
      Hydrometra                           |                                                                          |      3  2.7|
      Inflammation, Acute                  |                                                                          |      1  2.0|
      Inflammation, Chronic Active         |                            2                                             |      6  1.7|
      Endometrium, Hyperplasia             |    2  2     3        2  1                                                |     36  1.9|
      Epithelium, Metaplasia, Squamous     |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Myelofibrosis                        | 1                                                                        |      5  1.2|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  29                                                               
NTP Experiment-Test: 05061-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 09:33:30  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 4| 7| 4| 4| 7| 7| 5|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 5| 1| 5| 5| 3| 3| 5|                                            |            |
                                           | 3| 3| 3| 7| 3| 5| 7| 3| 3| 5|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      A     |
    1.0%                                   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |      L     |
    71LF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Myeloid Cell, Sternal, Hyperplasia   |                            2                                             |      1  2.0|
      Sternal, Myelofibrosis               |    2  1              2  1                                                |     32  1.8|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +           +                                                            |  12        |
      Pancreatic, Hyperplasia, Lymphoid    |                                                                          |      1  1.0|
      Renal, Hyperplasia, Plasma Cell      |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +                                             |  55        |
      Depletion Lymphoid                   |                                                                          |      1  4.0|
      Hyperplasia, Lymphoid                |                         2                                                |      1  2.0|
      Inflammation, Acute                  |                            2                                             |      1  2.0|
      Pigmentation                         |                                                                          |      2  2.0|
      Sinus, Ectasia                       |                         2                                                |      2  2.5|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  56        |
      Angiectasis                          |                                                                          |      4  1.5|
      Depletion Lymphoid                   |                                                                          |      1  3.0|
      Hemorrhage                           |                                                                          |      2  2.5|
      Hyperplasia, Lymphoid                |                                                                          |      6  2.5|
      Infiltration Cellular, Histiocyte    |    1                 1  1                                                |     24  1.0|
      Inflammation, Chronic Active         |                            2                                             |      3  2.3|
      Mineralization                       | 1                                                                        |      1  1.0|
      Pigmentation                         |    1                 1  1                                                |     24  1.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Depletion Lymphoid                   |                                                                          |      2  2.5|
      Hematopoietic Cell Proliferation     |             2              2                                             |     13  2.5|
      Hyperplasia, Lymphoid                |                      1  2                                                |     14  1.6|
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  +  +  +  M  +  +  +  +  +                                             |  48        |
      Cyst                                 |    1                                                                     |     16  1.0|
      Depletion Lymphoid                   |                            2                                             |      2  2.5|
      Hemorrhage                           |                      1                                                   |      1  1.0|
      Hyperplasia, Lymphoid                |                         2                                                |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  M  M  +  M  +  +  M  +  +                                             |  35        |
      Hyperplasia                          | 2                          2                                             |      9  1.3|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Subcutaneous Tissue, Cyst Epithelial |                                                                          |            |
          Inclusion                        |                                                                          |      1     |
      Subcutaneous Tissue, Fibrosis        |                                                                          |      1  2.0|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Chronic Active                  |                                                                          |      2  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  30                                                               
NTP Experiment-Test: 05061-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 09:33:30  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 4| 7| 4| 4| 7| 7| 5|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 5| 1| 5| 5| 3| 3| 5|                                            |            |
                                           | 3| 3| 3| 7| 3| 5| 7| 3| 3| 5|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      A     |
    1.0%                                   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |      L     |
    71LF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  M  +  M  M  +  +  +                                             |  48        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Perivascular, Inflammation, Chronic  |                                                                          |      1  1.0|
      Thalamus, Mineralization             |    1  1                                                                  |     15  1.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hemorrhage                           |                                                                          |      4  1.3|
      Inflammation, Chronic Active         |                                                                          |      4  1.3|
      Leukocytosis                         |                                                                          |      1  3.0|
      Pleura, Inflammation, Acute          |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +     +  +  +  +  +  +  +  +                                             |  55        |
      Inflammation, Acute                  |                      1  1                                                |      9  1.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Acute                           |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  59        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         | +                                                                        |   3        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  M  +  M  +  +  +  +                                             |  54        |
      Glomerulosclerosis                   |                                                                          |      3  1.7|
      Hydronephrosis                       |                                                                          |      1  2.0|
      Inflammation, Chronic                | 1  1  1           1     2  1                                             |     46  1.2|
      Metaplasia, Osseous                  |                         1                                                |      3  1.0|
      Pelvis, Transitional Epithelium,     |                                                                          |            |
           Hyperplasia                     |             2                                                            |      1  2.0|
      Renal Tubule, Atrophy                |                                                                          |      1  1.0|
      Renal Tubule, Pigmentation           | 1  1  1     1        1  1                                                |     43  1.0|
      Renal Tubule, Regeneration           |       1     1        1                                                   |      7  1.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Autolysis                            |                                                                          |      1  3.0|
      Inflammation, Chronic                |          1                                                               |      7  1.0|
      Inflammation, Chronic Active         | 1  1  2              1  1  1                                             |     43  1.1|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  31                                                               
NTP Experiment-Test: 05061-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 09:33:30  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 6| 5| 6| 7| 7| 4| 7| 7| 4| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 2| 1| 1| 2| 2| 2| 2| 5| 2| 2| 2| 0| 2| 2| 2| 5| 2| 2| 5| 3| 3| 3| 2|             
                                           | 9| 9| 9| 8| 3| 9| 9| 9| 9| 7| 9| 3| 3| 1| 3| 9| 9| 7| 9| 9| 5| 0| 0| 0| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    2.0%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    71HF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |          4                                                               |             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Autolysis                            |          4                                                               |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         |    1                 1           1        1                              |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Peyer's Patch, Hyperplasia           |                                                                   3      |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Peyer's Patch, Hyperplasia           |    4                                         2                           |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Peyer's Patch, Hyperplasia           |                                                                          |             
      Peyer's Patch, Inflammation, Acute   |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |          4                                                               |             
      Basophilic Focus                     | 2                 1                    1                    1            |             
      Clear Cell Focus                     | 1     1     1                                                  1  2  3   |             
      Eosinophilic Focus                   |       1                                                              4   |             
      Fatty Change                         | 1  1                       1                 2  1     1              1  1|             
      Fibrosis                             |                                                                          |             
      Hematopoietic Cell Proliferation     |                1                 2                                      1|             
      Hemorrhage                           |                                                                   2      |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic Active         | 1  1                 1     1        1        1  1  1  1     1     1  1   |             
      Necrosis, Coagulative                |                                  3           1     1        1     1  1   |             
      Pigmentation                         | 2  2  1  2  2  2  2  2        2  2  1  1  1  2  2  1  2  2  1  2  1  2  1|             
                                            __________________________________________________________________________|             
   Mesentery                               |          +           +        +  +                                       |             
      Inflammation, Chronic Active         |                      4        2  2                                       |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Autolysis                            |          4                                                               |             
      Fibrosis                             |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         |                      2        2        1     1  1                    1   |             
      Vacuolization Cytoplasmic            |    1  1     1        1        2  1           1                    1  1  1|             
      Duct, Dilatation                     |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                            1                                1            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  32                                                               
NTP Experiment-Test: 05061-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 09:33:30  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 6| 5| 6| 7| 7| 4| 7| 7| 4| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 2| 1| 1| 2| 2| 2| 2| 5| 2| 2| 2| 0| 2| 2| 2| 5| 2| 2| 5| 3| 3| 3| 2|             
                                           | 9| 9| 9| 8| 3| 9| 9| 9| 9| 7| 9| 3| 3| 1| 3| 9| 9| 7| 9| 9| 5| 0| 0| 0| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    2.0%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    71HF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Parotid Gland, Autolysis             |          3                                                               |             
      Submandibular Gland, Autolysis       |          3                                                               |             
      Submandibular Gland, Inflammation,   |                                                                          |             
           Chronic                         |       1     1  1  1  2  1                 1  1  1  1  1  1     1  1  1  1|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |    1           1  1        2                       2  2        2     2   |             
      Autolysis                            |          4                                                               |             
      Erosion                              |                                                                          |             
      Hyperkeratosis                       |    1           1  1                                2           1     2   |             
      Hyperplasia, Basal Cell              |                            2                                   1         |             
      Hyperplasia, Squamous                |             4                             2                              |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         | 2  2                 2                       2     2     2     2  1  1   |             
      Ulcer                                |             3                                                            |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +|             
      Autolysis                            |          4                                                               |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         | 1  1  1              1           1                       1           1   |             
      Mineralization                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |          3                                                               |             
      Inflammation, Chronic                |       1                                         1              1     1  1|             
      Mineralization                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |          4                                                               |             
      Degeneration, Fatty                  |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |          4                                                               |             
      Hematopoietic Cell Proliferation     |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  A  +  +  +  +  +     +  +  +  +  +  +  +     +  +     +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  M  M  +  +  M  M  +  +  +  +  M  M  +  M  +  +  M  +  +  +  M  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  M  +|             
      Autolysis                            |          3                                                               |             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hyperplasia           |    2                                         2        2                  |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |          4                                                               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  33                                                               
NTP Experiment-Test: 05061-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 09:33:30  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 6| 5| 6| 7| 7| 4| 7| 7| 4| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 2| 1| 1| 2| 2| 2| 2| 5| 2| 2| 2| 0| 2| 2| 2| 5| 2| 2| 5| 3| 3| 3| 2|             
                                           | 9| 9| 9| 8| 3| 9| 9| 9| 9| 7| 9| 3| 3| 1| 3| 9| 9| 7| 9| 9| 5| 0| 0| 0| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    2.0%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    71HF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      C-Cell, Hyperplasia                  |                      1                                                   |             
      Follicle, Cyst                       |                                                                      2   |             
      Follicular Cell, Hyperplasia         |                   1  1                    1  1        1        1     1   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |                                  +                                       |             
      Duct, Dilatation                     |                                  2                                       |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Abscess                              |                                  4                                       |             
      Angiectasis                          |                                                                      2   |             
      Cyst                                 | 4  2                                      2        2           2         |             
      Cyst, Multiple                       |                                                                          |             
      Periovarian Tissue, Cyst, Multiple   |                                                                          |             
      Periovarian Tissue, Hemorrhage       |                                                                          |             
      Periovarian Tissue, Inflammation,    |                                                                          |             
           Chronic Active                  |       1              1  1     1              1        1  2     1  1  1  1|             
      Periovarian Tissue, Pigmentation     |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Fibrosis                             |                                                                          |             
      Hydrometra                           |                            2                       2                     |             
      Inflammation, Chronic Active         |                   1  1           1                       1               |             
      Endometrium, Hyperplasia             | 2  2              2     3  2     1  1     2  2  2  2  2  2  2  1  2  1  1|             
      Epithelium, Metaplasia, Squamous     |                                                                          |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                  +                                       |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Myelofibrosis                        |                                                                          |             
      Myeloid Cell, Sternal, Hyperplasia   |                                        4                                 |             
      Sternal, Autolysis                   |          4                                                               |             
      Sternal, Myelofibrosis               | 2  3        1     2  1  2           2     2  3  X     2  3     2  1  1  1|             
                                            __________________________________________________________________________|             
   Lymph Node                              |             +        +              +                          +     +   |             
      Lumbar, Hyperplasia, Lymphoid        |                      1                                                   |             
      Mediastinal, Hyperplasia, Lymphoid   |                                                                      2   |             
      Mediastinal, Hyperplasia, Plasma Cell|                                                                      2   |             
      Pancreatic, Hyperplasia, Lymphoid    |                                     4                                    |             
      Pancreatic, Infiltration Cellular,   |                                                                          |             
           Histiocyte                      |                                                                          |             
      Pancreatic, Pigmentation             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  34                                                               
NTP Experiment-Test: 05061-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 09:33:30  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 6| 5| 6| 7| 7| 4| 7| 7| 4| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 2| 1| 1| 2| 2| 2| 2| 5| 2| 2| 2| 0| 2| 2| 2| 5| 2| 2| 5| 3| 3| 3| 2|             
                                           | 9| 9| 9| 8| 3| 9| 9| 9| 9| 7| 9| 3| 3| 1| 3| 9| 9| 7| 9| 9| 5| 0| 0| 0| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    2.0%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    71HF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Renal, Sinus, Ectasia                |             3                                                            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  I  +  +  +  M  M  +  +  M  +  +  M  M  +  M|             
      Autolysis                            |          4                                                               |             
      Hyperplasia, Lymphoid                |                                                 3                        |             
      Hyperplasia, Plasma Cell             |                                                 3                        |             
      Pigmentation                         |                                     2                                    |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Angiectasis                          |                                                                      2   |             
      Hyperplasia, Lymphoid                |                      2        2     2                             2      |             
      Infiltration Cellular, Histiocyte    | 1     1              1  1  1     1        1  1  1  1  1  1  1     1  1   |             
      Inflammation, Chronic Active         |                                                                          |             
      Pigmentation                         | 1     1              1  1  1     1        1  1  1  1  1  1  1     1  1   |             
      Sinus, Ectasia                       |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |          4                                                               |             
      Depletion Lymphoid                   |                                                                          |             
      Hematopoietic Cell Proliferation     |                3                 3     3                                2|             
      Hyperplasia, Lymphoid                |    2                 1                       3                           |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  +  M  M  M  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                      1  1                    1  1  2  1  1  1  1  1  1  1|             
      Depletion Lymphoid                   |                               2  3                                       |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                |                      1                                                   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  +  +  M  M  M  +  M  M  +  M  M  +  +  +  +  M  +  M  M  +  M  +  M  M|             
      Hyperplasia                          |                                        1                                 |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |          3                                                               |             
      Epidermis, Inflammation, Acute       |                                                                          |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic Active                  |                                  2                                       |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |          +                                                               |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Thalamus, Mineralization             |       1           1     1     1              1  1        1        1  1  1|             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                     +                                    |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  35                                                               
NTP Experiment-Test: 05061-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 09:33:30  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 6| 5| 6| 7| 7| 4| 7| 7| 4| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 2| 1| 1| 2| 2| 2| 2| 5| 2| 2| 2| 0| 2| 2| 2| 5| 2| 2| 5| 3| 3| 3| 2|             
                                           | 9| 9| 9| 8| 3| 9| 9| 9| 9| 7| 9| 3| 3| 1| 3| 9| 9| 7| 9| 9| 5| 0| 0| 0| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    2.0%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    71HF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Autolysis                            |          3                                                               |             
      Hemorrhage                           |    1        1                                                            |             
      Infiltration Cellular, Histiocyte    |                                                                      2   |             
      Inflammation, Chronic Active         |                                                                   1  2   |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +|             
      Inflammation, Acute                  |                      1                       1  1                        |             
      Glands, Inflammation, Acute          |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |          4                                                               |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                         +                                                |             
      Cornea, Inflammation, Chronic Active |                         3                                                |             
      Cornea, Neovascularization           |                         2                                                |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                         +                                                |             
      Inflammation, Chronic                |                         1                                                |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |          4                                                               |             
      Glomerulosclerosis                   |                                  2              2                        |             
      Inflammation, Chronic                | 2  2  2        1  1  2  2  1  1  1  1     1  1  X  1  1  1  1  1  1  1  1|             
      Metaplasia, Osseous                  |                                              1                           |             
      Papilla, Mineralization              |                                                                          |             
      Renal Tubule, Atrophy                |                1                                                         |             
      Renal Tubule, Mineralization         |          2                             1                                 |             
      Renal Tubule, Pigmentation           | 1  1  1  1  1  2  1  1  1     1  1           1  X     1  1     1  1  1  1|             
      Renal Tubule, Regeneration           |    1                                                                     |             
      Transitional Epithelium,             |                                                                          |             
          Mineralization                   |                         1                                                |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |          4                                                               |             
      Inflammation, Chronic                |                                                             1            |             
      Inflammation, Chronic Active         | 1  1  1     1  1  1  1  1     1  1     1  1  1  1     1  1     1  1  1  1|             
      Arteriole, Necrosis, Fibrinoid       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  36                                                               
NTP Experiment-Test: 05061-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 09:33:30  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 4| 7| 7| 7| 5| 4| 7| 7| 7| 7| 7| 7| 4| 7| 6| 5| 4| 4| 7| 7| 6|             
                             DAY ON TEST   | 3| 3| 3| 8| 5| 3| 3| 3| 5| 5| 2| 2| 2| 2| 2| 3| 5| 3| 9| 6| 5| 5| 3| 3| 6|             
                                           | 0| 0| 0| 0| 7| 0| 0| 0| 3| 7| 9| 9| 9| 9| 9| 0| 5| 0| 7| 2| 5| 7| 0| 0| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    2.0%                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    71HF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Autolysis                            |                                                                          |             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  M|             
      Autolysis                            |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         |       1              1                                                   |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Peyer's Patch, Hyperplasia           |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  M  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  M  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  A  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                         3|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  A  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                         4|             
      Peyer's Patch, Hyperplasia           |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  A  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                         2|             
      Peyer's Patch, Hyperplasia           |                                                                          |             
      Peyer's Patch, Inflammation, Acute   |                   2                                                      |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Basophilic Focus                     |                                                                         1|             
      Clear Cell Focus                     |    2                                         2                           |             
      Eosinophilic Focus                   |                                                                          |             
      Fatty Change                         |       2                    1                 2  1                 1      |             
      Fibrosis                             |                                        1                                 |             
      Hematopoietic Cell Proliferation     |                                                                         2|             
      Hemorrhage                           |                                                                          |             
      Inflammation, Acute                  |             2                                               1  1         |             
      Inflammation, Chronic Active         | 1  1                 1     1  1     2  1     1  1  2     1        1  1   |             
      Necrosis, Coagulative                |    1     2  2        1     1  1     1           1     1  1  2  1  1  1  2|             
      Pigmentation                         | 1  2  1  2  1  2  1  1  1  1  2  2  1  2  2  2  1  2  2  1  1  1  2  2  1|             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                       +                 +|             
      Inflammation, Chronic Active         |                                                                         3|             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                2                                                         |             
      Autolysis                            |                                                                         2|             
      Fibrosis                             |                4                                                         |             
      Inflammation, Chronic                |                            1                                             |             
      Inflammation, Chronic Active         |    1  1        2  1                 1                                   4|             
      Vacuolization Cytoplasmic            | 1              1  1                 1  1  1           2                 1|             
      Duct, Dilatation                     |                4                                                         |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Inflammation, Chronic                |             1                                                            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  37                                                               
NTP Experiment-Test: 05061-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 09:33:30  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 4| 7| 7| 7| 5| 4| 7| 7| 7| 7| 7| 7| 4| 7| 6| 5| 4| 4| 7| 7| 6|             
                             DAY ON TEST   | 3| 3| 3| 8| 5| 3| 3| 3| 5| 5| 2| 2| 2| 2| 2| 3| 5| 3| 9| 6| 5| 5| 3| 3| 6|             
                                           | 0| 0| 0| 0| 7| 0| 0| 0| 3| 7| 9| 9| 9| 9| 9| 0| 5| 0| 7| 2| 5| 7| 0| 0| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    2.0%                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    71HF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Parotid Gland, Autolysis             |                                                                          |             
      Submandibular Gland, Autolysis       |                                                                          |             
      Submandibular Gland, Inflammation,   |                                                                          |             
           Chronic                         | 1  1           1     2     1  1  1     1        1        1  1     1      |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           | 2  1                    1  1  2     2     1     2        2  3  2  1  2  1|             
      Autolysis                            |                                                                          |             
      Erosion                              |                                                                          |             
      Hyperkeratosis                       | 1  1                    1  1        1     1     2        2  3  2  2  2  1|             
      Hyperplasia, Basal Cell              |                                                                      2   |             
      Hyperplasia, Squamous                |                                                                          |             
      Inflammation, Chronic                |                                                             2            |             
      Inflammation, Chronic Active         | 1              1     1     1  2           2  1  2        2           2  1|             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Inflammation, Chronic                |                                                 2                        |             
      Inflammation, Chronic Active         | 1     1        1              1        1  2        2              1  1  1|             
      Mineralization                       |          1                                                               |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Inflammation, Chronic                |                   1                                                  1   |             
      Mineralization                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Degeneration, Fatty                  |                               2                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia                          |                                                          3               |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                         1|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +     +  +  +  +     +  +  +  +  +  +     +  +  +        +  +  +|             
      Hyperplasia                          |                                                                         1|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +  +  +  M  +  +  M  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M|             
      Autolysis                            |                                                                          |             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hyperplasia           |    1  2              2                                      1            |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Autolysis                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  38                                                               
NTP Experiment-Test: 05061-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 09:33:30  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 4| 7| 7| 7| 5| 4| 7| 7| 7| 7| 7| 7| 4| 7| 6| 5| 4| 4| 7| 7| 6|             
                             DAY ON TEST   | 3| 3| 3| 8| 5| 3| 3| 3| 5| 5| 2| 2| 2| 2| 2| 3| 5| 3| 9| 6| 5| 5| 3| 3| 6|             
                                           | 0| 0| 0| 0| 7| 0| 0| 0| 3| 7| 9| 9| 9| 9| 9| 0| 5| 0| 7| 2| 5| 7| 0| 0| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    2.0%                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    71HF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Inflammation, Chronic Active         |                      1                                                   |             
      C-Cell, Hyperplasia                  |                                                                          |             
      Follicle, Cyst                       |                                                                          |             
      Follicular Cell, Hyperplasia         | 1  1  1        1  1  1                    1  1                    1      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |                                                                          |             
      Duct, Dilatation                     |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                                         4|             
      Angiectasis                          |                   3           3                       4                  |             
      Cyst                                 |    3                          3                             2            |             
      Cyst, Multiple                       |                                                                          |             
      Periovarian Tissue, Cyst, Multiple   |                         3                                                |             
      Periovarian Tissue, Hemorrhage       |                         4                                                |             
      Periovarian Tissue, Inflammation,    |                                                                          |             
           Chronic Active                  | 1  1  1        1     1        1     2  1     1           1        1  1  1|             
      Periovarian Tissue, Pigmentation     |                         1                                                |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                    3                     |             
      Fibrosis                             |                                                                   2      |             
      Hydrometra                           |                                                 3                        |             
      Inflammation, Chronic Active         | 1                                                                        |             
      Endometrium, Hyperplasia             | 2  2  2  1  1  2  2  3     2  2     1  2  2  2  2           2  3  1     2|             
      Epithelium, Metaplasia, Squamous     |                                                                          |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Myelofibrosis                        |                                                 1                        |             
      Myeloid Cell, Sternal, Hyperplasia   |                                                                          |             
      Sternal, Autolysis                   |                                                                          |             
      Sternal, Myelofibrosis               | 2  2  2        1  3           2     X  2  2  3     2              2  1   |             
                                            __________________________________________________________________________|             
   Lymph Node                              |          +                             +           +  +                  |             
      Lumbar, Hyperplasia, Lymphoid        |                                                                          |             
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |             
      Mediastinal, Hyperplasia, Plasma Cell|                                                                          |             
      Pancreatic, Hyperplasia, Lymphoid    |                                                                          |             
      Pancreatic, Infiltration Cellular,   |                                                                          |             
           Histiocyte                      |                                                                          |             
      Pancreatic, Pigmentation             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  39                                                               
NTP Experiment-Test: 05061-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 09:33:30  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 4| 7| 7| 7| 5| 4| 7| 7| 7| 7| 7| 7| 4| 7| 6| 5| 4| 4| 7| 7| 6|             
                             DAY ON TEST   | 3| 3| 3| 8| 5| 3| 3| 3| 5| 5| 2| 2| 2| 2| 2| 3| 5| 3| 9| 6| 5| 5| 3| 3| 6|             
                                           | 0| 0| 0| 0| 7| 0| 0| 0| 3| 7| 9| 9| 9| 9| 9| 0| 5| 0| 7| 2| 5| 7| 0| 0| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    2.0%                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    71HF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Renal, Sinus, Ectasia                |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  M  +  +  M  +  +  M  +  M  I  +  +  M  +  +  +  +  +  +  +  I  M  M|             
      Autolysis                            |                                                                          |             
      Hyperplasia, Lymphoid                | 1                                                                        |             
      Hyperplasia, Plasma Cell             |                                                                          |             
      Pigmentation                         | 1                                                                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M|             
      Angiectasis                          | 1                                                                        |             
      Hyperplasia, Lymphoid                |       2                                   2  1                    1  1   |             
      Infiltration Cellular, Histiocyte    | 1  1        1  1     1           1  1     1  1     1        1  1  1  1   |             
      Inflammation, Chronic Active         |                                                                          |             
      Pigmentation                         | 1  1        1  1     1           1  1     1  1     1        1  1  1  1   |             
      Sinus, Ectasia                       |                                              2                           |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Depletion Lymphoid                   |             2           2                                               2|             
      Hematopoietic Cell Proliferation     |                                                    2                 2  3|             
      Hyperplasia, Lymphoid                |       1           2                       1                              |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  M  +  M  M  +  +  +  M  +  M|             
      Cyst                                 | 1  1  1        1  1  1     1  1  1  1  1  1     2           1  1         |             
      Depletion Lymphoid                   |                                  4                       1           3   |             
      Hemorrhage                           | 2                                                                        |             
      Hyperplasia, Lymphoid                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  M  M  +  M  M  +  M  +  +  M  M  +  +  M  +  M  +  M  +  +  M  +  +|             
      Hyperplasia                          |                                                       2                 1|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Epidermis, Inflammation, Acute       |                                                                          |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic Active                  |                                                                         1|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |          +                                                               |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Thalamus, Mineralization             | 1     1  1     1  1        1        1  1        1        1  1            |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  40                                                               
NTP Experiment-Test: 05061-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 09:33:30  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 4| 7| 7| 7| 5| 4| 7| 7| 7| 7| 7| 7| 4| 7| 6| 5| 4| 4| 7| 7| 6|             
                             DAY ON TEST   | 3| 3| 3| 8| 5| 3| 3| 3| 5| 5| 2| 2| 2| 2| 2| 3| 5| 3| 9| 6| 5| 5| 3| 3| 6|             
                                           | 0| 0| 0| 0| 7| 0| 0| 0| 3| 7| 9| 9| 9| 9| 9| 0| 5| 0| 7| 2| 5| 7| 0| 0| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    2.0%                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    71HF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Autolysis                            |                                                                          |             
      Hemorrhage                           |    2              1              1     2           2                     |             
      Infiltration Cellular, Histiocyte    |                                                                          |             
      Inflammation, Chronic Active         |                1                    2                                    |             
      Alveolar Epithelium, Hyperplasia     |                      1                                                   |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                                              1                    1  1   |             
      Glands, Inflammation, Acute          |                                                 1                        |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Autolysis                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Cornea, Inflammation, Chronic Active |                                                                          |             
      Cornea, Neovascularization           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                   +      |             
      Inflammation, Chronic                |                                                                   1      |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Glomerulosclerosis                   |                                  2                 3                     |             
      Inflammation, Chronic                | 1  1  1     1  1     2  1  2  1  1  X  1  1  1  2  2  1  1  2  1  2  1  1|             
      Metaplasia, Osseous                  |                                                                          |             
      Papilla, Mineralization              |                                                                          |             
      Renal Tubule, Atrophy                |                                                                          |             
      Renal Tubule, Mineralization         |                         2                                                |             
      Renal Tubule, Pigmentation           | 1  1  1  1     1  1  1        1  2  1  1  1  1     1  1           1  2  1|             
      Renal Tubule, Regeneration           |                      1                                                   |             
      Transitional Epithelium,             |                                                                          |             
          Mineralization                   |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                         3|             
      Inflammation, Chronic                |             1              1                    1           2  1         |             
      Inflammation, Chronic Active         | 1  1  1        1  1  1  1     1  1  1  1  1  1     1  1  1        2  1  1|             
      Arteriole, Necrosis, Fibrinoid       |                                                                   2      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  41                                                               
NTP Experiment-Test: 05061-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 09:33:30  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 5| 5| 5| 4| 4| 7| 7| 6|                                            |            |
                             DAY ON TEST   | 3| 6| 9| 6| 3| 5| 5| 3| 2| 3|                                            |            |
                                           | 0| 4| 6| 8| 8| 7| 7| 0| 4| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |      A     |
    2.0%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
    71HF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  57        |
      Autolysis                            |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  A  +  +  +  +  +                                             |  54        |
      Autolysis                            |                         3                                                |      2  3.5|
      Inflammation, Chronic                |                   1                                                      |      1  1.0|
      Inflammation, Chronic Active         | 1     1                                                                  |      8  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Peyer's Patch, Hyperplasia           |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +                                             |  57        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  57        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  A  +  +  +  +  +                                             |  56        |
      Autolysis                            |                         4                                                |      2  3.5|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  A  +  +  +  +  +                                             |  56        |
      Autolysis                            |                         4                                                |      2  4.0|
      Peyer's Patch, Hyperplasia           |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  56        |
      Autolysis                            |                         2                                                |      2  2.0|
      Peyer's Patch, Hyperplasia           |    2                                                                     |      1  2.0|
      Peyer's Patch, Inflammation, Acute   |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Autolysis                            |                                                                          |      1  4.0|
      Basophilic Focus                     |             1                                                            |      6  1.2|
      Clear Cell Focus                     |    1                                                                     |      9  1.6|
      Eosinophilic Focus                   |                                                                          |      2  2.5|
      Fatty Change                         | 1     2              1  1  1                                             |     18  1.2|
      Fibrosis                             |                                                                          |      1  1.0|
      Hematopoietic Cell Proliferation     |       1                 2                                                |      6  1.5|
      Hemorrhage                           |                                                                          |      1  2.0|
      Inflammation, Acute                  |                   1                                                      |      4  1.3|
      Inflammation, Chronic Active         | 2  2           1           1                                             |     29  1.1|
      Necrosis, Coagulative                |    2           1  2     2                                                |     25  1.4|
      Pigmentation                         | 2  2  1  1  1  1  1  1  2  1                                             |     58  1.5|
                                            __________________________________________________________________________|____________|
   Mesentery                               |    +  +                                                                  |   8        |
      Inflammation, Chronic Active         |                                                                          |      4  2.8|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  M  +  +  +  +  +  +  +                                             |  59        |
      Atrophy                              |    1                                                                     |      2  1.5|
      Autolysis                            |                                                                          |      2  3.0|
      Fibrosis                             |                                                                          |      1  4.0|
      Inflammation, Chronic                |                                                                          |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  42                                                               
NTP Experiment-Test: 05061-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 09:33:30  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 5| 5| 5| 4| 4| 7| 7| 6|                                            |            |
                             DAY ON TEST   | 3| 6| 9| 6| 3| 5| 5| 3| 2| 3|                                            |            |
                                           | 0| 4| 6| 8| 8| 7| 7| 0| 4| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |      A     |
    2.0%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
    71HF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Chronic Active         | 1  2        1        1  2  1                                             |     18  1.4|
      Vacuolization Cytoplasmic            |    2     2  1                                                            |     21  1.2|
      Duct, Dilatation                     |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  M  +  +                                             |  57        |
      Inflammation, Chronic                |                1  1                                                      |      5  1.0|
      Parotid Gland, Autolysis             |                                                                          |      1  3.0|
      Submandibular Gland, Autolysis       |                                                                          |      1  3.0|
      Submandibular Gland, Inflammation,   |                                                                          |            |
           Chronic                         | 1  2  2  1                 2                                             |     33  1.2|
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Acanthosis                           |          2  3  2  2  2                                                   |     27  1.7|
      Autolysis                            |                                                                          |      1  4.0|
      Erosion                              |             2                                                            |      1  2.0|
      Hyperkeratosis                       |          2  3  2  2  2                                                   |     24  1.6|
      Hyperplasia, Basal Cell              |             2  1                                                         |      5  1.6|
      Hyperplasia, Squamous                |                                                                          |      2  3.0|
      Inflammation, Chronic                |                1                                                         |      2  1.5|
      Inflammation, Chronic Active         | 3           2        2  2                                                |     24  1.7|
      Ulcer                                |                      2                                                   |      2  2.5|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Autolysis                            |                                                                          |      1  4.0|
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Inflammation, Chronic Active         | 2        1              1  1                                             |     21  1.1|
      Mineralization                       |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Autolysis                            |                                                                          |      1  3.0|
      Inflammation, Chronic                |             1                                                            |      8  1.0|
      Mineralization                       |       2                                                                  |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Autolysis                            |                                                                          |      1  4.0|
      Degeneration, Fatty                  |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     |                         2                                                |      1  2.0|
      Hyperplasia                          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Autolysis                            |                                                                          |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  43                                                               
NTP Experiment-Test: 05061-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 09:33:30  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 5| 5| 5| 4| 4| 7| 7| 6|                                            |            |
                             DAY ON TEST   | 3| 6| 9| 6| 3| 5| 5| 3| 2| 3|                                            |            |
                                           | 0| 4| 6| 8| 8| 7| 7| 0| 4| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |      A     |
    2.0%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
    71HF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Hematopoietic Cell Proliferation     |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  M  +  +        +  +  +                                             |  48        |
      Hyperplasia                          |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  +  +  +  M  +  +  +  +  +                                             |  43        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  52        |
      Autolysis                            |                                                                          |      1  3.0|
      Pars Distalis, Cyst                  |                   1                                                      |      1  1.0|
      Pars Distalis, Hyperplasia           |    2                                                                     |      8  1.8|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Autolysis                            |                                                                          |      1  4.0|
      Inflammation, Chronic Active         | 1  1                                                                     |      3  1.0|
      C-Cell, Hyperplasia                  |                                                                          |      1  1.0|
      Follicle, Cyst                       |                         2                                                |      2  2.0|
      Follicular Cell, Hyperplasia         | 1                    1                                                   |     18  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |                                                                          |   1        |
      Duct, Dilatation                     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +                                             |  57        |
      Abscess                              |                                                                          |      2  4.0|
      Angiectasis                          |                                                                          |      4  3.0|
      Cyst                                 |       1                                                                  |      9  2.3|
      Cyst, Multiple                       |                            2                                             |      1  2.0|
      Periovarian Tissue, Cyst, Multiple   |                                                                          |      1  3.0|
      Periovarian Tissue, Hemorrhage       |                                                                          |      1  4.0|
      Periovarian Tissue, Inflammation,    |                                                                          |            |
           Chronic Active                  | 2  2                 1  2                                                |     28  1.2|
      Periovarian Tissue, Pigmentation     |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Angiectasis                          |                                                                          |      1  3.0|
      Fibrosis                             |                                                                          |      1  2.0|
      Hydrometra                           |                                                                          |      3  2.3|
      Inflammation, Chronic Active         |    1  1                                                                  |      7  1.0|
      Endometrium, Hyperplasia             | 2  2  2  2     2  2  2     3                                             |     45  1.9|
      Epithelium, Metaplasia, Squamous     |                      2                                                   |      1  2.0|
                                            __________________________________________________________________________|____________|
   Vagina                                  |                                                                          |   1        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  44                                                               
NTP Experiment-Test: 05061-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 09:33:30  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 5| 5| 5| 4| 4| 7| 7| 6|                                            |            |
                             DAY ON TEST   | 3| 6| 9| 6| 3| 5| 5| 3| 2| 3|                                            |            |
                                           | 0| 4| 6| 8| 8| 7| 7| 0| 4| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |      A     |
    2.0%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
    71HF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Myelofibrosis                        |                                                                          |      1  1.0|
      Myeloid Cell, Sternal, Hyperplasia   |                         3                                                |      2  3.5|
      Sternal, Autolysis                   |                                                                          |      1  4.0|
      Sternal, Myelofibrosis               | 2  1        1        1     1                                             |     34  1.8|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |    +  +                 +                                                |  12        |
      Lumbar, Hyperplasia, Lymphoid        |                                                                          |      1  1.0|
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |      1  2.0|
      Mediastinal, Hyperplasia, Plasma Cell|                                                                          |      1  2.0|
      Pancreatic, Hyperplasia, Lymphoid    |                                                                          |      1  4.0|
      Pancreatic, Infiltration Cellular,   |                                                                          |            |
           Histiocyte                      |                         1                                                |      1  1.0|
      Pancreatic, Pigmentation             |                         1                                                |      1  1.0|
      Renal, Sinus, Ectasia                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  M  M  +  +  +  +  M  +  +                                             |  41        |
      Autolysis                            |                                                                          |      1  4.0|
      Hyperplasia, Lymphoid                |                                                                          |      2  2.0|
      Hyperplasia, Plasma Cell             |                                                                          |      1  3.0|
      Pigmentation                         |          1                                                               |      3  1.3|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  M  +  +  +  +  +  +                                             |  52        |
      Angiectasis                          |             2                                                            |      3  1.7|
      Hyperplasia, Lymphoid                | 2                                                                        |     10  1.7|
      Infiltration Cellular, Histiocyte    |    1  1           1  1     1                                             |     34  1.0|
      Inflammation, Chronic Active         |    2                    2                                                |      2  2.0|
      Pigmentation                         |    1  1           1  1     1                                             |     34  1.0|
      Sinus, Ectasia                       |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  I  +  +  +                                             |  59        |
      Autolysis                            |                                                                          |      1  4.0|
      Depletion Lymphoid                   |                                                                          |      3  2.0|
      Hematopoietic Cell Proliferation     | 2  2  2                 2                                                |     11  2.4|
      Hyperplasia, Lymphoid                |          2           2                                                   |      8  1.8|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  M  M  M  +  +  M  +  M  +                                             |  42        |
      Cyst                                 |                            1                                             |     28  1.1|
      Depletion Lymphoid                   |             2                                                            |      6  2.5|
      Hemorrhage                           |                                                                          |      1  2.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  45                                                               
NTP Experiment-Test: 05061-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 09:33:30  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 5| 5| 5| 4| 4| 7| 7| 6|                                            |            |
                             DAY ON TEST   | 3| 6| 9| 6| 3| 5| 5| 3| 2| 3|                                            |            |
                                           | 0| 4| 6| 8| 8| 7| 7| 0| 4| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |      A     |
    2.0%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
    71HF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  M  M  +  +  +  +  M  M  M                                             |  30        |
      Hyperplasia                          |                                                                          |      3  1.3|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Autolysis                            |                                                                          |      1  3.0|
      Epidermis, Inflammation, Acute       |                         1                                                |      1  1.0|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Chronic Active                  |                                                                          |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Thalamus, Mineralization             | 1  1              1  1                                                   |     25  1.0|
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Autolysis                            |                                                                          |      1  3.0|
      Hemorrhage                           |       1                                                                  |      8  1.4|
      Infiltration Cellular, Histiocyte    |                                                                          |      1  2.0|
      Inflammation, Chronic Active         |                      1     1                                             |      6  1.3|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  I  +  +  +                                             |  53        |
      Inflammation, Acute                  |                      1                                                   |      7  1.0|
      Glands, Inflammation, Acute          |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  57        |
      Autolysis                            |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
      Cornea, Inflammation, Chronic Active |                                                                          |      1  3.0|
      Cornea, Neovascularization           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   2        |
      Inflammation, Chronic                |                                                                          |      2  1.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  46                                                               
NTP Experiment-Test: 05061-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 09:33:30  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 5| 5| 5| 4| 4| 7| 7| 6|                                            |            |
                             DAY ON TEST   | 3| 6| 9| 6| 3| 5| 5| 3| 2| 3|                                            |            |
                                           | 0| 4| 6| 8| 8| 7| 7| 0| 4| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |      A     |
    2.0%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
    71HF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Autolysis                            |                                                                          |      1  4.0|
      Glomerulosclerosis                   |                                                                          |      4  2.3|
      Inflammation, Chronic                | 1  2  1  1  1  2     1  1  2                                             |     54  1.3|
      Metaplasia, Osseous                  |                                                                          |      1  1.0|
      Papilla, Mineralization              |       2                                                                  |      1  2.0|
      Renal Tubule, Atrophy                |    2                 1                                                   |      3  1.3|
      Renal Tubule, Mineralization         |                                                                          |      3  1.7|
      Renal Tubule, Pigmentation           | 1  2     2           2  1  2                                             |     43  1.2|
      Renal Tubule, Regeneration           |    2              1                                                      |      4  1.3|
      Transitional Epithelium,             |                                                                          |            |
          Mineralization                   |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Autolysis                            |                                                                          |      2  3.5|
      Inflammation, Chronic                |                1  1                                                      |      8  1.1|
      Inflammation, Chronic Active         | 1  1  1  1           1  2  1                                             |     46  1.0|
      Arteriole, Necrosis, Fibrinoid       |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  47                                                               
NTP Experiment-Test: 05061-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 09:33:30  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 7| 6| 7| 4| 7| 7| 2| 7| 7| 5| 4| 3| 7| 4| 7| 7| 4| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 6| 3| 2| 3| 6| 3| 3| 9| 3| 2| 2| 8| 9| 3| 6| 0| 3| 4| 3| 3| 3| 3| 3|             
                                           | 2| 2| 0| 2| 1| 0| 0| 0| 1| 2| 2| 3| 1| 0| 3| 1| 0| 5| 1| 5| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    UNTREATE                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    D 71UM                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Inflammation, Chronic Active         | 1        2                                                           1   |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                          3               |             
      Inflammation, Chronic Active         |                                        2                                 |             
      Peyer's Patch, Hyperplasia           |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                          3               |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                          3               |             
      Ulcer, Acute                         |                                                                          |             
      Peyer's Patch, Hyperplasia           |                                              2                           |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                          3               |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                          3               |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                          3               |             
      Inflammation, Acute, Necrotizing     |                                     3                                    |             
      Peyer's Patch, Hyperplasia, Lymphoid |                                                                          |             
      Peyer's Patch, Hyperplasia           |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |          1                                                               |             
      Clear Cell Focus                     |                                                       1  1  1            |             
      Cytoplasmic Alteration               |                                                                          |             
      Fatty Change                         |       2           1                          1  1        3               |             
      Hematopoietic Cell Proliferation     |                                                    1                     |             
      Inflammation, Acute                  |                   1                                                      |             
      Inflammation, Chronic Active         |    1     2           1     1  1        3  1                 1            |             
      Mineralization                       |                                                                          |             
      Necrosis, Coagulative                |                   2        1        3     1                 1            |             
      Pigmentation                         |                                                                          |             
      Bile Duct, Hyperplasia               |          2                                                               |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                  +                 +                     |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Autolysis                            |                                                          3               |             
      Cytoplasmic Alteration               |                                                                          |             
      Inflammation, Chronic                |                   1                                                      |             
      Inflammation, Chronic Active         | 1              1     1     1                 1                 1         |             
      Vacuolization Cytoplasmic            |    1        2        1           2        2                 1        1   |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  48                                                               
NTP Experiment-Test: 05061-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 09:33:30  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 7| 6| 7| 4| 7| 7| 2| 7| 7| 5| 4| 3| 7| 4| 7| 7| 4| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 6| 3| 2| 3| 6| 3| 3| 9| 3| 2| 2| 8| 9| 3| 6| 0| 3| 4| 3| 3| 3| 3| 3|             
                                           | 2| 2| 0| 2| 1| 0| 0| 0| 1| 2| 2| 3| 1| 0| 3| 1| 0| 5| 1| 5| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    UNTREATE                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    D 71UM                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Inflammation, Chronic                |                2                                                         |             
      Parotid Gland, Inflammation, Chronic |                                                                          |             
      Submandibular Gland, Inflammation,   |                                                                          |             
           Chronic                         | 1  1  1  1  1        1                 1  1  1              1     1  1  1|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                         1                                                |             
      Autolysis                            |                                                                          |             
      Edema                                |                                        2                                 |             
      Erosion                              |                         1                                                |             
      Hyperkeratosis                       |                         1                                                |             
      Inflammation, Chronic Active         |                         2              1                                 |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         | 1                                            1                           |             
      Mineralization                       |                                                                1         |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Dysplasia                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |                                                                          |             
      Inflammation, Chronic                | 1                                                                        |             
      Mineralization                       |                                     1                                    |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                        1                                 |             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                      1                                                   |             
      Inflammation, Acute                  |                                        1                                 |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +     +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    1     1                                   2           2               |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  +  M  M  +  +  M  M  +  M  M  M  +  +  +  +  M  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  I  +  +  M  +  M  +  +  +  +  M  +  +  M  +  +  +  I  +  +  +  +  +|             
      Pars Distalis, Cyst                  | 1                                                                 2      |             
      Pars Distalis, Hyperplasia           | 1  2     1                 2           1  2                          2   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Ultimobranchial Cyst                 |                                                                          |             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  49                                                               
NTP Experiment-Test: 05061-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 09:33:30  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 7| 6| 7| 4| 7| 7| 2| 7| 7| 5| 4| 3| 7| 4| 7| 7| 4| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 6| 3| 2| 3| 6| 3| 3| 9| 3| 2| 2| 8| 9| 3| 6| 0| 3| 4| 3| 3| 3| 3| 3|             
                                           | 2| 2| 0| 2| 1| 0| 0| 0| 1| 2| 2| 3| 1| 0| 3| 1| 0| 5| 1| 5| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    UNTREATE                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    D 71UM                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM - cont                |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       |                                     +                                    |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +|             
      Inflammation, Chronic Active         | 1        1  1  1     1                 1              1              1   |             
                                            __________________________________________________________________________|             
   Penis                                   |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +              +     +        +        M     +        +     +         |             
      Abscess                              |                                                                          |             
      Inflammation, Chronic                |                   2                                                      |             
      Inflammation, Chronic Active         |                         2        1                             1         |             
      Duct, Dilatation                     | 4  3                                            2        4     3         |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |       1                                                                  |             
      Inflammation, Chronic Active         |    1           1     1        1  1     1  1  1                 1        1|             
      Artery, Inflammation, Chronic Active |                                                                          |             
      Epithelium, Hyperplasia              |                                  2                                       |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                        1                                 |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Seminiferous Tubule, Atrophy         |                                                 1                        |             
      Seminiferous Tubule, Mineralization  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Myeloid Cell, Sternal, Hyperplasia   |                                                    3                     |             
      Sternal, Infiltration Cellular, Mast |                                                                          |             
          Cell                             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +                             +  +                 +                     |             
      Inguinal, Hyperplasia, Lymphoid      |                                                                          |             
      Lumbar, Hyperplasia, Lymphoid        |                                                                          |             
      Lumbar, Hyperplasia                  |                                                                          |             
      Pancreatic, Hyperplasia, Lymphoid    | 3                                                                        |             
      Pancreatic, Infiltration Cellular,   |                                                                          |             
           Histiocyte                      |                                                                          |             
      Pancreatic, Pigmentation             |                                                                          |             
      Renal, Angiectasis                   |                                                                          |             
      Renal, Hyperplasia, Lymphoid         |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  +  M  +  +  M  M  +  +  M  +  M  M  +  +  +  M  +  +  +  M  M  M  +  M|             
      Depletion Lymphoid                   |                                        2                 4               |             
      Hyperplasia, Lymphoid                |                                              2                           |             
      Infiltration Cellular, Histiocyte    |                                                                          |             
      Inflammation, Chronic Active         |                                        2                                 |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  50                                                               
NTP Experiment-Test: 05061-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 09:33:30  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 7| 6| 7| 4| 7| 7| 2| 7| 7| 5| 4| 3| 7| 4| 7| 7| 4| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 6| 3| 2| 3| 6| 3| 3| 9| 3| 2| 2| 8| 9| 3| 6| 0| 3| 4| 3| 3| 3| 3| 3|             
                                           | 2| 2| 0| 2| 1| 0| 0| 0| 1| 2| 2| 3| 1| 0| 3| 1| 0| 5| 1| 5| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    UNTREATE                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    D 71UM                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Pigmentation                         |                                        1                                 |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +|             
      Angiectasis                          |    1     2  1  1     4                       2     1           2  2  2   |             
      Depletion Lymphoid                   |                                                                          |             
      Hemorrhage                           |                      4                                                   |             
      Hyperplasia, Lymphoid                |                                           2                              |             
      Infiltration Cellular, Histiocyte    |          1     1                             1        1           1      |             
      Pigmentation                         |          1     1                                      1           1      |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Depletion Lymphoid                   |                                                          2               |             
      Hematopoietic Cell Proliferation     |                                     4  4           2                     |             
      Inflammation, Chronic Active         |                                  3                                       |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  M  M  +  M  M  M  +  +  M  +  +  M  +  +  +  +  M  +  +  +  +|             
      Cyst                                 |                               1                                          |             
      Cyst, Multiple                       |                                                                          |             
      Depletion Lymphoid                   |                                        3                                 |             
      Hyperplasia, Lymphoid                |                                           3                              |             
      Pigmentation                         |                                        1                                 |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  +  M  M  M  +  M  M  M  M  M  +  M  M  M  +  M  M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic Active         |                                        1                                 |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Acute                           |       2                                         1                        |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Cartilage, Tarsal, Hyperplasia       |                                     2                                    |             
      Joint, Tarsal, Hyperostosis          |       4     3              4        4        3     3                     |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                  +                 +                     |             
      Fibrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cerebellum, Necrosis                 |                                     2                                    |             
      Cerebrum, Necrosis                   |                                     2                                    |             
      Thalamus, Mineralization             |       1           1        1  1           1  1  1        1     1     1  1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  51                                                               
NTP Experiment-Test: 05061-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 09:33:30  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 7| 6| 7| 4| 7| 7| 2| 7| 7| 5| 4| 3| 7| 4| 7| 7| 4| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 6| 3| 2| 3| 6| 3| 3| 9| 3| 2| 2| 8| 9| 3| 6| 0| 3| 4| 3| 3| 3| 3| 3|             
                                           | 2| 2| 0| 2| 1| 0| 0| 0| 1| 2| 2| 3| 1| 0| 3| 1| 0| 5| 1| 5| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    UNTREATE                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    D 71UM                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Hemorrhage                           |                   1        1        4                       1           1|             
      Infiltration Cellular, Histiocyte    |                         3                 2                              |             
      Inflammation, Chronic Active         |                                                                          |             
      Mineralization                       |                                     1                                    |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Bronchiole, Hyperplasia              |                                                                          |             
      Peribronchiolar, Inflammation,       |                                                                          |             
          Chronic                          |                                                                          |             
      Perivascular, Inflammation, Chronic  |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +|             
      Crystals                             |                                                                          |             
      Inflammation, Acute                  |    1           1        1                          1  1                  |             
      Glands, Crystals                     |                                                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Acute                           |                                     1                                    |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                         +                                                |             
      Cornea, Inflammation, Chronic Active |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                         +                                                |             
      Inflammation, Chronic Active         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 | 1                                                                        |             
      Inflammation, Chronic                |       2           1                             1                        |             
      Inflammation, Chronic Active         | 1  1     1  1  1     2  1  1  1        1  1  2        1  1  1  2  1  1  1|             
      Proximal Convoluted Renal Tubule,    |                                                                          |             
           Regeneration                    |                                                                          |             
      Proximal Convoluted Renal Tubule,    |                                                                          |             
           Vacuolization Cytoplasmic       |                                           2                              |             
      Renal Tubule, Mineralization         |                                                                          |             
      Renal Tubule, Regeneration           |                      2  1                                                |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                          4               |             
      Calculus Micro Observation Only      |                1                                                         |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         | 1  1     1  1        1           1     1  1  1     1           1  1     1|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  52                                                               
NTP Experiment-Test: 05061-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 09:33:30  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 4| 7| 7| 7| 7| 4| 7| 7| 4|             
                             DAY ON TEST   | 3| 3| 3| 2| 0| 6| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 6| 3| 3| 3| 3| 5| 3| 3| 6|             
                                           | 1| 1| 1| 3| 5| 0| 1| 1| 1| 1| 2| 2| 2| 0| 2| 2| 0| 2| 2| 1| 2| 8| 1| 1| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    UNTREATE                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    D 71UM                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |             4                                                            |             
      Inflammation, Chronic Active         |    1                 1                 1     1     1  1              1   |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Peyer's Patch, Hyperplasia           |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |             3                                                            |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |             2                                                            |             
      Ulcer, Acute                         |                                        4                                 |             
      Peyer's Patch, Hyperplasia           |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |             4                                                            |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |             3                                                            |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |             4                                                            |             
      Inflammation, Acute, Necrotizing     |                                                                          |             
      Peyer's Patch, Hyperplasia, Lymphoid |                                  4                                       |             
      Peyer's Patch, Hyperplasia           |                                           2                              |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Clear Cell Focus                     |                                                             2            |             
      Cytoplasmic Alteration               |                   2                                                      |             
      Fatty Change                         |                2                                1     1              1  2|             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic Active         |                2                       4                    3           1|             
      Mineralization                       |                                                             1            |             
      Necrosis, Coagulative                |                2                       3                                 |             
      Pigmentation                         |                                                             3            |             
      Bile Duct, Hyperplasia               |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                      1  1                                                |             
      Autolysis                            |                                                                          |             
      Cytoplasmic Alteration               |                                           1  1                           |             
      Inflammation, Chronic                |                                                 1                        |             
      Inflammation, Chronic Active         |       1           1        1  1  1  1                       1     1  1   |             
      Vacuolization Cytoplasmic            |                      1  1  1              1  1           2        1      |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  53                                                               
NTP Experiment-Test: 05061-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 09:33:30  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 4| 7| 7| 7| 7| 4| 7| 7| 4|             
                             DAY ON TEST   | 3| 3| 3| 2| 0| 6| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 6| 3| 3| 3| 3| 5| 3| 3| 6|             
                                           | 1| 1| 1| 3| 5| 0| 1| 1| 1| 1| 2| 2| 2| 0| 2| 2| 0| 2| 2| 1| 2| 8| 1| 1| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    UNTREATE                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    D 71UM                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Parotid Gland, Inflammation, Chronic |                                                                   1  1   |             
      Submandibular Gland, Inflammation,   |                                                                          |             
           Chronic                         | 1  1  1  1     1  1  1  2  1  2  1  1  1  1  1  2  1     1  2  1  1  2  1|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                                                          |             
      Autolysis                            |             3                                                            |             
      Edema                                |                                                                          |             
      Erosion                              |                                                                          |             
      Hyperkeratosis                       |                                        2                                 |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |             4                                                            |             
      Inflammation, Chronic                |                1                                                         |             
      Inflammation, Chronic Active         |    1  1                 1     1     1  2              1  1        1      |             
      Mineralization                       | 1  1                          1                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                   +      |             
      Dysplasia                            |                                                                   3      |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |                                        1                       1         |             
      Inflammation, Chronic                |                         1                          1              1  1   |             
      Mineralization                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +     +  +  +  +  +  +  +     +  +     +  +  +  +     +  +  +|             
      Hyperplasia                          |                   3           1           1  1                          1|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  +  +  M  +  M  M  +  +  +  +  +  +  +  M  +  M  +  M  M  +  +  M  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |                                     1                                    |             
      Pars Distalis, Hyperplasia           |                         1  2     2                 1                     |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                      1                                                   |             
      Ultimobranchial Cyst                 |                                                                          |             
      Follicular Cell, Hyperplasia         | 1                    1                                                   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  54                                                               
NTP Experiment-Test: 05061-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 09:33:30  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 4| 7| 7| 7| 7| 4| 7| 7| 4|             
                             DAY ON TEST   | 3| 3| 3| 2| 0| 6| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 6| 3| 3| 3| 3| 5| 3| 3| 6|             
                                           | 1| 1| 1| 3| 5| 0| 1| 1| 1| 1| 2| 2| 2| 0| 2| 2| 0| 2| 2| 1| 2| 8| 1| 1| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    UNTREATE                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    D 71UM                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM - cont                |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         | 1  1  1  1        1     3  1  2  1  1  4  1        1  1  1  1     1      |             
                                            __________________________________________________________________________|             
   Penis                                   |                                                                +         |             
      Inflammation, Acute                  |                                                                2         |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |    +  +  +  +     +  +                 +        +              +  +      |             
      Abscess                              |       4                                                                  |             
      Inflammation, Chronic                |                                                 1                        |             
      Inflammation, Chronic Active         |    3     3  2     1  1                 4                       4  2      |             
      Duct, Dilatation                     |    3  3     3     2  3                                            3      |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                1                                1                        |             
      Inflammation, Chronic Active         | 1  1        1     1  1  1  1  1     1  3     1     1     1  1     1  1   |             
      Artery, Inflammation, Chronic Active |                                                                4         |             
      Epithelium, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                   1     1                                                |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Seminiferous Tubule, Atrophy         |                            2                    1              1        1|             
      Seminiferous Tubule, Mineralization  |          1                 1                                             |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Myeloid Cell, Sternal, Hyperplasia   |                                                                          |             
      Sternal, Infiltration Cellular, Mast |                                                                          |             
          Cell                             |                                                                      2   |             
                                            __________________________________________________________________________|             
   Lymph Node                              |             +                       +  +                       +         |             
      Inguinal, Hyperplasia, Lymphoid      |                                                                2         |             
      Lumbar, Hyperplasia, Lymphoid        |                                                                          |             
      Lumbar, Hyperplasia                  |                                        4                                 |             
      Pancreatic, Hyperplasia, Lymphoid    |                                     2                                    |             
      Pancreatic, Infiltration Cellular,   |                                                                          |             
           Histiocyte                      |                                     1                                    |             
      Pancreatic, Pigmentation             |                                     1                                    |             
      Renal, Angiectasis                   |                                                                          |             
      Renal, Hyperplasia, Lymphoid         |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  +  M  +  M  +  +  +  M  +  +  +  M  +  M  +  M  +  +  M  +  +  M  +  +|             
      Depletion Lymphoid                   |                                                                          |             
      Hyperplasia, Lymphoid                |                   2  2                                                   |             
      Infiltration Cellular, Histiocyte    |                                                    1                     |             
      Inflammation, Chronic Active         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  55                                                               
NTP Experiment-Test: 05061-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 09:33:30  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 4| 7| 7| 7| 7| 4| 7| 7| 4|             
                             DAY ON TEST   | 3| 3| 3| 2| 0| 6| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 6| 3| 3| 3| 3| 5| 3| 3| 6|             
                                           | 1| 1| 1| 3| 5| 0| 1| 1| 1| 1| 2| 2| 2| 0| 2| 2| 0| 2| 2| 1| 2| 8| 1| 1| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    UNTREATE                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    D 71UM                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Pigmentation                         |                                  1                 1                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  M  +  +  +|             
      Angiectasis                          | 1  2              1  2  2  2  2  2  1                    2  1            |             
      Depletion Lymphoid                   |       3                                                                  |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                |          1        2        2  2                                          |             
      Infiltration Cellular, Histiocyte    | 1  1  1  1        1  1        1     1              1  1     1     1  1   |             
      Pigmentation                         | 1  1  1  1        1  1        1     1              1  1     1     1  1   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 1                                                                        |             
      Depletion Lymphoid                   |                                                                          |             
      Hematopoietic Cell Proliferation     |                         3              4                                 |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  M  M  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M|             
      Cyst                                 |                               1                                          |             
      Cyst, Multiple                       |                                                                   1      |             
      Depletion Lymphoid                   |                         3                                                |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Pigmentation                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  +  M  M  M  M  M  M  M  +  M  M  +  M  M  M  M  +  M  M  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic Active         |             3                                                     1      |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Acute                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +     M  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  M  +  +  M|             
      Cartilage, Tarsal, Hyperplasia       |                                                                          |             
      Joint, Tarsal, Hyperostosis          |    4  3           4                                                      |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |             +                                                            |             
      Fibrosis                             |             2                                                            |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cerebellum, Necrosis                 |                                                                          |             
      Cerebrum, Necrosis                   |                                                                          |             
      Thalamus, Mineralization             |       1  1     1  1     1  1        1  1     1           1     1        1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                        2                                 |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  56                                                               
NTP Experiment-Test: 05061-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 09:33:30  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 4| 7| 7| 7| 7| 4| 7| 7| 4|             
                             DAY ON TEST   | 3| 3| 3| 2| 0| 6| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 6| 3| 3| 3| 3| 5| 3| 3| 6|             
                                           | 1| 1| 1| 3| 5| 0| 1| 1| 1| 1| 2| 2| 2| 0| 2| 2| 0| 2| 2| 1| 2| 8| 1| 1| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    UNTREATE                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    D 71UM                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Hemorrhage                           |          1                    1  1                 1                     |             
      Infiltration Cellular, Histiocyte    |                                                                          |             
      Inflammation, Chronic Active         |                                                       1                  |             
      Mineralization                       |                                                                          |             
      Alveolar Epithelium, Hyperplasia     | 1                                                                        |             
      Bronchiole, Hyperplasia              |                                           2                              |             
      Peribronchiolar, Inflammation,       |                                                                          |             
          Chronic                          |                                        2                                 |             
      Perivascular, Inflammation, Chronic  |                                        2                                 |             
                                            __________________________________________________________________________|             
   Nose                                    | +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Crystals                             |                1                                                         |             
      Inflammation, Acute                  |                1  2                    2     1              1     1      |             
      Glands, Crystals                     |                         1                    1                           |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Acute                           |       1                                                                  |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                       +                  |             
                                            __________________________________________________________________________|             
   Eye                                     |                                              +                           |             
      Cornea, Inflammation, Chronic Active |                                              3                           |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                              +                           |             
      Inflammation, Chronic Active         |                                              3                           |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Inflammation, Chronic                |                1                       2        1              1        1|             
      Inflammation, Chronic Active         | 1  2  2  2  1     1  1  1  1  1  1  1     1  1     1  1  1  1     2  1   |             
      Proximal Convoluted Renal Tubule,    |                                                                          |             
           Regeneration                    |                                                                   1      |             
      Proximal Convoluted Renal Tubule,    |                                                                          |             
           Vacuolization Cytoplasmic       |                                                                          |             
      Renal Tubule, Mineralization         |                   1                                                      |             
      Renal Tubule, Regeneration           |    2                                                                     |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |             2                                                            |             
      Calculus Micro Observation Only      | 2                                                           X            |             
      Inflammation, Chronic                |                                                 1                       1|             
      Inflammation, Chronic Active         |    1  1  1           1  1  1  2  1  1  4  1  1     1  1  1        1  1   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  57                                                               
NTP Experiment-Test: 05061-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 09:33:30  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 4| 4| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 6| 6| 3| 3| 3| 3|                                            |            |
                                           | 2| 2| 2| 1| 0| 0| 2| 2| 1| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    UNTREATE                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
    D 71UM                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  M  +  +  M  +  +  +                                             |  56        |
      Autolysis                            |                                                                          |      1  4.0|
      Inflammation, Chronic Active         |    1                 1                                                   |     12  1.1|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Autolysis                            |                                                                          |      1  3.0|
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Peyer's Patch, Hyperplasia           |          2                                                               |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Autolysis                            |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Autolysis                            |                                                                          |      2  2.5|
      Ulcer, Acute                         |                                                                          |      1  4.0|
      Peyer's Patch, Hyperplasia           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Autolysis                            |                                                                          |      2  3.5|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Autolysis                            |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Autolysis                            |                                                                          |      2  3.5|
      Inflammation, Acute, Necrotizing     |                                                                          |      1  3.0|
      Peyer's Patch, Hyperplasia, Lymphoid |                                                                          |      1  4.0|
      Peyer's Patch, Hyperplasia           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Angiectasis                          |                                                                          |      1  1.0|
      Clear Cell Focus                     |                                                                          |      4  1.3|
      Cytoplasmic Alteration               |                                                                          |      1  2.0|
      Fatty Change                         |             1                                                            |     11  1.5|
      Hematopoietic Cell Proliferation     |                                                                          |      1  1.0|
      Inflammation, Acute                  |                                                                          |      1  1.0|
      Inflammation, Chronic Active         |             1     3  1                                                   |     15  1.7|
      Mineralization                       |                                                                          |      1  1.0|
      Necrosis, Coagulative                |             1     3                                                      |      9  1.9|
      Pigmentation                         |                                                                          |      1  3.0|
      Bile Duct, Hyperplasia               |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Atrophy                              |                                                                          |      2  1.0|
      Autolysis                            |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  58                                                               
NTP Experiment-Test: 05061-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 09:33:30  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 4| 4| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 6| 6| 3| 3| 3| 3|                                            |            |
                                           | 2| 2| 2| 1| 0| 0| 2| 2| 1| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    UNTREATE                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
    D 71UM                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Cytoplasmic Alteration               |    1              1                                                      |      4  1.0|
      Inflammation, Chronic                |                                                                          |      2  1.0|
      Inflammation, Chronic Active         |    1                 1  1  1                                             |     19  1.0|
      Vacuolization Cytoplasmic            | 1  1              1  1  1  2                                             |     20  1.3|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Inflammation, Chronic                |       1                                                                  |      2  1.5|
      Parotid Gland, Inflammation, Chronic |                                                                          |      2  1.0|
      Submandibular Gland, Inflammation,   |                                                                          |            |
           Chronic                         | 1  1     1  1  1  1  1  1  1                                             |     45  1.1|
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Acanthosis                           |                                                                          |      1  1.0|
      Autolysis                            |                                                                          |      1  3.0|
      Edema                                |                                                                          |      1  2.0|
      Erosion                              |                                                                          |      1  1.0|
      Hyperkeratosis                       |                                                                          |      2  1.5|
      Inflammation, Chronic Active         |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Autolysis                            |                                                                          |      1  4.0|
      Inflammation, Chronic                |                                                                          |      1  1.0|
      Inflammation, Chronic Active         | 1        2        1  1                                                   |     15  1.1|
      Mineralization                       |                                                                          |      4  1.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |       +              +     +                                             |   4        |
      Dysplasia                            |       4              1     2                                             |      4  2.5|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cardiomyopathy                       |             1                                                            |      3  1.0|
      Inflammation, Chronic                |                      1     2                                             |      7  1.1|
      Mineralization                       |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Inflammation, Chronic Active         |    1                       1                                             |      3  1.0|
      Pigmentation                         |    1                       1                                             |      2  1.0|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperplasia                          |                                                                          |      1  1.0|
      Inflammation, Acute                  |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +        +  +  +  +                                             |  51        |
      Hyperplasia                          |                                                                          |      9  1.4|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  59                                                               
NTP Experiment-Test: 05061-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 09:33:30  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 4| 4| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 6| 6| 3| 3| 3| 3|                                            |            |
                                           | 2| 2| 2| 1| 0| 0| 2| 2| 1| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    UNTREATE                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
    D 71UM                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  +  +  M  +  +  +  +  +  +                                             |  40        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  52        |
      Pars Distalis, Cyst                  |          1              2                                                |      5  1.4|
      Pars Distalis, Hyperplasia           |       1           2                                                      |     13  1.5|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Inflammation, Chronic                |                                                                          |      1  1.0|
      Ultimobranchial Cyst                 |       1                                                                  |      1  1.0|
      Follicular Cell, Hyperplasia         |                                                                          |      2  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                         +                                                |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Coagulating Gland                       |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Inflammation, Chronic Active         |    1  1           2     1  1                                             |     30  1.2|
                                            __________________________________________________________________________|____________|
   Penis                                   |                                                                          |   1        |
      Inflammation, Acute                  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |    +     +        +                                                      |  21        |
      Abscess                              |                                                                          |      1  4.0|
      Inflammation, Chronic                |                                                                          |      2  1.5|
      Inflammation, Chronic Active         |    4     2        4                                                      |     14  2.4|
      Duct, Dilatation                     |          4                                                               |     12  3.1|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  M  +  +  +  M  +  +                                             |  57        |
      Inflammation, Chronic                |             1  1                                                         |      5  1.0|
      Inflammation, Chronic Active         | 1  1  1           3     1  1                                             |     32  1.1|
      Artery, Inflammation, Chronic Active |                                                                          |      1  4.0|
      Epithelium, Hyperplasia              |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Inflammation, Chronic Active         |                   2                                                      |      4  1.3|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Seminiferous Tubule, Atrophy         |             1  1                                                         |      7  1.1|
      Seminiferous Tubule, Mineralization  |                                                                          |      2  1.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Myeloid Cell, Sternal, Hyperplasia   |                                                                          |      1  3.0|
      Sternal, Infiltration Cellular, Mast |                                                                          |            |
          Cell                             |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  60                                                               
NTP Experiment-Test: 05061-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 09:33:30  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 4| 4| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 6| 6| 3| 3| 3| 3|                                            |            |
                                           | 2| 2| 2| 1| 0| 0| 2| 2| 1| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    UNTREATE                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
    D 71UM                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                   +        +                                             |  10        |
      Inguinal, Hyperplasia, Lymphoid      |                                                                          |      1  2.0|
      Lumbar, Hyperplasia, Lymphoid        |                   3                                                      |      1  3.0|
      Lumbar, Hyperplasia                  |                                                                          |      1  4.0|
      Pancreatic, Hyperplasia, Lymphoid    |                                                                          |      2  2.5|
      Pancreatic, Infiltration Cellular,   |                                                                          |            |
           Histiocyte                      |                                                                          |      1  1.0|
      Pancreatic, Pigmentation             |                                                                          |      1  1.0|
      Renal, Angiectasis                   |                   1                                                      |      1  1.0|
      Renal, Hyperplasia, Lymphoid         |                   2                                                      |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  +  +  +  +  +  +  +  +  +                                             |  38        |
      Depletion Lymphoid                   |                         3                                                |      3  3.0|
      Hyperplasia, Lymphoid                |                                                                          |      3  2.0|
      Infiltration Cellular, Histiocyte    |          1              1                                                |      3  1.0|
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Pigmentation                         |          2              1                                                |      5  1.2|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  54        |
      Angiectasis                          | 2  2              3                                                      |     24  1.8|
      Depletion Lymphoid                   |                                                                          |      1  3.0|
      Hemorrhage                           |                                                                          |      1  4.0|
      Hyperplasia, Lymphoid                |                      2                                                   |      6  1.8|
      Infiltration Cellular, Histiocyte    | 1  1  1  1           1  1                                                |     24  1.0|
      Pigmentation                         | 1  1  1  1           1  1                                                |     23  1.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Angiectasis                          |                                                                          |      1  1.0|
      Depletion Lymphoid                   |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     |                   3                                                      |      6  3.3|
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  M  +  M  +  I  +                                             |  44        |
      Cyst                                 |                                                                          |      2  1.0|
      Cyst, Multiple                       |    1                                                                     |      2  1.0|
      Depletion Lymphoid                   |                                                                          |      2  3.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
      Pigmentation                         |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  +  +  M  M  M  M                                             |  11        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Inflammation, Acute                  |                2                                                         |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  61                                                               
NTP Experiment-Test: 05061-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 09:33:30  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 4| 4| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 6| 6| 3| 3| 3| 3|                                            |            |
                                           | 2| 2| 2| 1| 0| 0| 2| 2| 1| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    UNTREATE                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
    D 71UM                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Chronic Active         |                   1                                                      |      4  1.5|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Acute                           |                                                                          |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  M  +  +  +  +  +                                             |  51        |
      Cartilage, Tarsal, Hyperplasia       |                                                                          |      1  2.0|
      Joint, Tarsal, Hyperostosis          |    2           4        4                                                |     12  3.5|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   3        |
      Fibrosis                             |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cerebellum, Necrosis                 |                                                                          |      1  2.0|
      Cerebrum, Necrosis                   |                                                                          |      1  2.0|
      Thalamus, Mineralization             | 1           1  1                                                         |     26  1.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Congestion                           |                                                                          |      1  2.0|
      Hemorrhage                           |                                                                          |      9  1.3|
      Infiltration Cellular, Histiocyte    |                                                                          |      2  2.5|
      Inflammation, Chronic Active         |                                                                          |      1  1.0|
      Mineralization                       |                                                                          |      1  1.0|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      1  1.0|
      Bronchiole, Hyperplasia              |                                                                          |      1  2.0|
      Peribronchiolar, Inflammation,       |                                                                          |            |
          Chronic                          |                                                                          |      1  2.0|
      Perivascular, Inflammation, Chronic  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | M  +  +  +  +  +  M  +  M  +                                             |  53        |
      Crystals                             |                                                                          |      1  1.0|
      Inflammation, Acute                  |          1                 1                                             |     13  1.2|
      Glands, Crystals                     |                                                                          |      2  1.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Acute                           |                                                                          |      2  1.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Inflammation, Acute                  |                   1     1                                                |      2  1.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  62                                                               
NTP Experiment-Test: 05061-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 09:33:30  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 4| 4| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 6| 6| 3| 3| 3| 3|                                            |            |
                                           | 2| 2| 2| 1| 0| 0| 2| 2| 1| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    UNTREATE                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
    D 71UM                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   2        |
      Cornea, Inflammation, Chronic Active |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   2        |
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cyst                                 |                                                                          |      1  1.0|
      Inflammation, Chronic                |             1  1                                                         |     10  1.2|
      Inflammation, Chronic Active         | 2  2  1  1        1  1  1  1                                             |     47  1.2|
      Proximal Convoluted Renal Tubule,    |                                                                          |            |
           Regeneration                    | 2                                                                        |      2  1.5|
      Proximal Convoluted Renal Tubule,    |                                                                          |            |
           Vacuolization Cytoplasmic       |                                                                          |      1  2.0|
      Renal Tubule, Mineralization         |                                                                          |      1  1.0|
      Renal Tubule, Regeneration           |          2                                                               |      4  1.8|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Autolysis                            |                                                                          |      2  3.0|
      Calculus Micro Observation Only      |    3  3                                                                  |      5  2.3|
      Inflammation, Chronic                |                1                                                         |      3  1.0|
      Inflammation, Chronic Active         | 1     1  1        1  1  1  1                                             |     37  1.1|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  63                                                               
NTP Experiment-Test: 05061-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 09:33:30  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 5| 7| 4| 7| 6| 6| 7| 7| 6| 4| 6| 7| 6| 4| 5| 4| 7| 7| 4| 7| 5|             
                             DAY ON TEST   | 2| 2| 7| 7| 0| 3| 5| 3| 8| 1| 3| 3| 5| 6| 3| 3| 1| 5| 7| 5| 3| 3| 6| 3| 8|             
                                           | 9| 9| 3| 3| 5| 0| 8| 0| 9| 3| 0| 0| 4| 0| 3| 0| 2| 8| 2| 1| 0| 0| 0| 0| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    1.0%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    71LM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                            4                                             |             
      Inflammation, Chronic Active         |                               1  1  1        2              1  1     1   |             
      Epithelium, Pigmentation             |                                                                         1|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                            3                                             |             
      Inflammation, Chronic Active         |                                                             3            |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                            3                                             |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                            3                                             |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Epithelium, Hyperplasia              |                                                                          |             
      Peyer's Patch, Hyperplasia           |                                                                          |             
      Serosa, Inflammation, Chronic Active |                         1                                                |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Peyer's Patch, Inflammation, Chronic,|                                                                          |             
           Granulomatous                   |                                                             3            |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  M  A  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Peyer's Patch, Inflammation, Chronic,|                                                                          |             
           Granulomatous                   |                                                             3            |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Peyer's Patch, Hyperplasia           |                                                       3                  |             
      Peyer's Patch, Inflammation, Chronic,|                                                                          |             
           Granulomatous                   |                                                             3            |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                                                          |             
      Clear Cell Focus                     |                               1                                          |             
      Eosinophilic Focus                   |          3     1        1                                      1         |             
      Fatty Change                         |                   1                                      2               |             
      Fibrosis                             |                                                       2                  |             
      Hematopoietic Cell Proliferation     |          2  1           2           1                                    |             
      Inflammation, Acute                  |                   1                    1           1              1      |             
      Inflammation, Chronic Active         |             2                 1  1  2           1     2  1               |             
      Mineralization                       |                               2                                          |             
      Necrosis, Coagulative                |       1                 1     3  1     1        1  2  2  1        1      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  64                                                               
NTP Experiment-Test: 05061-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 09:33:30  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 5| 7| 4| 7| 6| 6| 7| 7| 6| 4| 6| 7| 6| 4| 5| 4| 7| 7| 4| 7| 5|             
                             DAY ON TEST   | 2| 2| 7| 7| 0| 3| 5| 3| 8| 1| 3| 3| 5| 6| 3| 3| 1| 5| 7| 5| 3| 3| 6| 3| 8|             
                                           | 9| 9| 3| 3| 5| 0| 8| 0| 9| 3| 0| 0| 4| 0| 3| 0| 2| 8| 2| 1| 0| 0| 0| 0| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    1.0%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    71LM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Nuclear Alteration                   |                                                                          |             
      Pigmentation                         | 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  2  1  1  1  1  1  1|             
      Bile Duct, Hyperplasia               |          2                                                               |             
      Centrilobular, Cytoplasmic Alteration|                   3                    3           2              3      |             
      Hepatocyte, Centrilobular,           |                                                                          |             
          Hypertrophy                      |                      1  2  2  2  2        2                          2   |             
                                            __________________________________________________________________________|             
   Mesentery                               |             +     +        +                          +                 +|             
      Inflammation, Chronic                |                   2                                                      |             
      Inflammation, Chronic Active         |             4                                         1                 2|             
      Necrosis, Coagulative                |                   3                                                      |             
      Thrombosis                           |                                                                         4|             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Ectopic Liver                        |                               X                                          |             
      Inflammation, Chronic Active         |       1     3        1     4        1                    1     1         |             
      Vacuolization Cytoplasmic            |    2  1                 1           2     1  1                 1     1  2|             
      Acinus, Atrophy                      |          3                                                               |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Sublingual Gland, Inflammation,      |                                                                          |             
          Chronic                          |                                                                          |             
      Submandibular Gland, Inflammation,   |                                                                          |             
           Chronic                         | 1  1  1  1                 1                          1        1        2|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                                          |             
      Acanthosis                           |       1        1  1  2                                                   |             
      Cyst                                 |                                                                          |             
      Diverticulum                         |                                                                          |             
      Hyperkeratosis                       |                1  1  1                                                   |             
      Hyperplasia, Basal Cell              |                                                                          |             
      Inflammation, Chronic Active         |    2                                                                 1   |             
      Ulcer                                |       1        2                                                         |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Mast Cell     |                                                                          |             
      Inflammation, Chronic                |                   1                    1                          1      |             
      Inflammation, Chronic Active         | 1              1           2  1  1  1        1           1  1  1        2|             
      Muscularis, Mineralization           |                                                    2                     |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                | 1        2           1        1     1                 1                  |             
      Necrosis, Coagulative                |                                                                          |             
      Coronary Artery, Thrombosis          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  65                                                               
NTP Experiment-Test: 05061-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 09:33:30  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 5| 7| 4| 7| 6| 6| 7| 7| 6| 4| 6| 7| 6| 4| 5| 4| 7| 7| 4| 7| 5|             
                             DAY ON TEST   | 2| 2| 7| 7| 0| 3| 5| 3| 8| 1| 3| 3| 5| 6| 3| 3| 1| 5| 7| 5| 3| 3| 6| 3| 8|             
                                           | 9| 9| 3| 3| 5| 0| 8| 0| 9| 3| 0| 0| 4| 0| 3| 0| 2| 8| 2| 1| 0| 0| 0| 0| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    1.0%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    71LM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |          1                                                               |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +     +  +  +  +  +  +     +  +  +     +  +  +  +     +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  M  +  +  M  +  M  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +|             
      Pars Distalis, Cyst                  | 2                                1        1                              |             
      Pars Distalis, Hyperplasia           |       1              1           1                                       |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Ultimobranchial Cyst                 |                                                                          |             
      Follicular Cell, Hyperplasia         |                1                                            1            |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       |          +                                                               |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |       1  1           1  1     1                 1           1        1  1|             
      Epithelium, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Penis                                   |                                  +                                       |             
      Hemorrhage                           |                                  2                                       |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                M                          +              +           +  +|             
      Abscess                              |                                                                          |             
      Inflammation, Chronic Active         |                                                                         1|             
      Duct, Dilatation                     |                                           2              4           3  3|             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         | 1        1           1        1  1  1     1           1  1  1  1        1|             
      Inflammation                         |    1                                                                     |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Cyst                                 |                         2                                                |             
      Fibrosis                             |                         2                                                |             
      Inflammation, Chronic Active         | 1     1                 2        1        1  1                           |             
      Artery, Thrombosis                   |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Interstitial Cell, Hyperplasia       |                                                                          |             
      Seminiferous Tubule, Mineralization  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  66                                                               
NTP Experiment-Test: 05061-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 09:33:30  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 5| 7| 4| 7| 6| 6| 7| 7| 6| 4| 6| 7| 6| 4| 5| 4| 7| 7| 4| 7| 5|             
                             DAY ON TEST   | 2| 2| 7| 7| 0| 3| 5| 3| 8| 1| 3| 3| 5| 6| 3| 3| 1| 5| 7| 5| 3| 3| 6| 3| 8|             
                                           | 9| 9| 3| 3| 5| 0| 8| 0| 9| 3| 0| 0| 4| 0| 3| 0| 2| 8| 2| 1| 0| 0| 0| 0| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    1.0%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    71LM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Myeloid Cell, Sternal, Hyperplasia   |             4                                                            |             
      Sternal, Inflammation, Granulomatous |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |          +     +                    +           +                       +|             
      Lumbar, Hyperplasia, Lymphoid        |                                     2                                    |             
      Lumbar, Inflammation, Chronic Active |                                     1                                    |             
      Mediastinal, Infiltration Cellular,  |                                                                          |             
           Histiocyte                      |                                                                         X|             
      Mediastinal, Pigmentation            |                                                                         1|             
      Renal, Inflammation, Chronic Active  |                                     3                                    |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  M  +  +  M  +  +  +  M  +  +  +  M  +  M  M  +  +  +  +  I  +  +  +  +|             
      Depletion Lymphoid                   |                                                                         3|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Hyperplasia, Plasma Cell             |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Pigmentation                         |                               1                                      1   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +     +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |       2  1                       1           1                       1   |             
      Congestion                           |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia, Lymphoid                |       4                                                                  |             
      Hyperplasia, Plasma Cell             |             3                                                            |             
      Infiltration Cellular, Histiocyte    | 1        1           1        1  1  1        1                 1     1  1|             
      Inflammation, Chronic Active         | 1        3                 2        3                       3  2         |             
      Pigmentation                         | 1        1           1        1  1  1        1                 1     1  1|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Depletion Lymphoid                   |                                                                          |             
      Hematopoietic Cell Proliferation     |       3  3  4           3           4     2           4        2        2|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Inflammation, Chronic Active         |                                                             2            |             
      Necrosis, Coagulative                |             1                                                            |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  M  +  M  +  +  +  M  M  +  +  +  +  +  +  M  +  M  +  +  +  +  M  +|             
      Cyst                                 |                                                                          |             
      Depletion Lymphoid                   |          3                          2        3           3               |             
      Infiltration Cellular, Histiocyte    |                                                                          |             
      Necrosis, Coagulative                |                                                                          |             
      Pigmentation                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  +  M  M  M  M  M  M  +  M  M  M  +  M  M  M  M  +  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Inflammation, Chronic Active         |                      1  1     1                             1  3         |             
      Subcutaneous Tissue, Cyst            |                                           2                              |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  67                                                               
NTP Experiment-Test: 05061-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 09:33:30  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 5| 7| 4| 7| 6| 6| 7| 7| 6| 4| 6| 7| 6| 4| 5| 4| 7| 7| 4| 7| 5|             
                             DAY ON TEST   | 2| 2| 7| 7| 0| 3| 5| 3| 8| 1| 3| 3| 5| 6| 3| 3| 1| 5| 7| 5| 3| 3| 6| 3| 8|             
                                           | 9| 9| 3| 3| 5| 0| 8| 0| 9| 3| 0| 0| 4| 0| 3| 0| 2| 8| 2| 1| 0| 0| 0| 0| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    1.0%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    71LM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Subcutaneous Tissue, Fibrosis        |                                                                2         |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +|             
      Joint, Tarsal, Hyperostosis          |                      3              3  4                                4|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |             +                                                            |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Thalamus, Mineralization             | 1     1  1              1     1     1        1        1  1  1            |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bronchiectasis                       |                                                                          |             
      Crystals                             |                                                                          |             
      Foreign Body                         |                                                                         1|             
      Granuloma                            |                                                                         1|             
      Hemorrhage                           |             1        1        2  1                             1         |             
      Infiltration Cellular, Histiocyte    |                                                                          |             
      Inflammation, Acute                  |             1                                                            |             
      Inflammation, Chronic Active         |                                                    2                     |             
      Bronchiole, Metaplasia, Squamous     |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  | 1  1        1                    1                       1               |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                +         |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Anterior, Synechia                   |                                                                          |             
      Cornea, Fibrosis                     |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                         +|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  M  +  +|             
      Autolysis                            |                                                                          |             
      Congestion                           |                                                                          |             
      Glomerulosclerosis                   |       1                                                                  |             
      Infiltration Cellular, Mononuclear   |                                                                          |             
          Cell                             |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         | 1  1  1  1           1  1  1  1  1  1     1  1        1  1  1  2     1  2|             
      Necrosis, Coagulative                |          1                                                               |             
      Artery, Necrosis, Fibrinoid          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  68                                                               
NTP Experiment-Test: 05061-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 09:33:30  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 5| 7| 4| 7| 6| 6| 7| 7| 6| 4| 6| 7| 6| 4| 5| 4| 7| 7| 4| 7| 5|             
                             DAY ON TEST   | 2| 2| 7| 7| 0| 3| 5| 3| 8| 1| 3| 3| 5| 6| 3| 3| 1| 5| 7| 5| 3| 3| 6| 3| 8|             
                                           | 9| 9| 3| 3| 5| 0| 8| 0| 9| 3| 0| 0| 4| 0| 3| 0| 2| 8| 2| 1| 0| 0| 0| 0| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    1.0%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    71LM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Pelvis, Transitional Epithelium,     |                                                                          |             
           Hyperplasia                     |                                                                          |             
      Proximal Convoluted Renal Tubule,    |                                                                          |             
           Hyperplasia                     |                                                                          |             
      Proximal Convoluted Renal Tubule,    |                                                                          |             
           Regeneration                    |                                                                          |             
      Renal Tubule, Mineralization         |          1                                1                              |             
      Renal Tubule, Pigmentation           | 1  1  1  1     1     1  1  1  1  1  1        1        3  1  1  1     1  1|             
      Renal Tubule, Regeneration           |       1                                                                  |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |          2                 4                                             |             
      Calculus Micro Observation Only      |                               2                                2         |             
      Inflammation, Chronic                |                   1                    1           1              1      |             
      Inflammation, Chronic Active         | 1  1     1           1        1  1  1     1  1        1     1        1   |             
      Transitional Epithelium, Hyperplasia |                                     1        2                           |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  69                                                               
NTP Experiment-Test: 05061-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 09:33:30  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 6| 6| 1| 7| 7| 6| 6| 4| 4| 7| 7| 6| 5| 4| 4| 7| 5| 4| 7| 7| 7| 5| 5|             
                             DAY ON TEST   | 5| 3| 4| 1| 5| 3| 3| 4| 3| 6| 5| 3| 0| 1| 0| 5| 5| 0| 5| 6| 3| 3| 1| 8| 7|             
                                           | 8| 0| 8| 8| 2| 0| 0| 7| 3| 4| 7| 0| 9| 1| 1| 8| 8| 6| 0| 0| 0| 0| 7| 2| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    1.0%                                   | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    71LM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  M  +  +     +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Autolysis                            |                                        4                                 |             
      Inflammation, Chronic Active         |    1           1                 1                                       |             
      Epithelium, Pigmentation             |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                        4                                 |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Autolysis                            |                                        4                                 |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                        4                                 |             
      Hemorrhage                           |                                                    1                     |             
      Hyperplasia, Lymphoid                |                1                                                         |             
      Epithelium, Hyperplasia              |                                                                          |             
      Peyer's Patch, Hyperplasia           |                                                                          |             
      Serosa, Inflammation, Chronic Active |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                        4                                 |             
      Peyer's Patch, Inflammation, Chronic,|                                                                          |             
           Granulomatous                   |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                        4                                 |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Inflammation, Acute                  |                                                    1                     |             
      Peyer's Patch, Inflammation, Chronic,|                                                                          |             
           Granulomatous                   |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                        4                                 |             
      Hyperplasia, Lymphoid                |                1                                                         |             
      Peyer's Patch, Hyperplasia           |       2                                                                  |             
      Peyer's Patch, Inflammation, Chronic,|                                                                          |             
           Granulomatous                   |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |       1                                            1                 1  1|             
      Clear Cell Focus                     |                                                                   1      |             
      Eosinophilic Focus                   |                                     2                       1            |             
      Fatty Change                         |                                                          1               |             
      Fibrosis                             |                                                                          |             
      Hematopoietic Cell Proliferation     |                                           2                              |             
      Inflammation, Acute                  | 1                                            1  1        1               |             
      Inflammation, Chronic Active         |                                     1                 1                  |             
      Mineralization                       |                                                                          |             
      Necrosis, Coagulative                | 1     2                    1                 1  1  1  1  1               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  70                                                               
NTP Experiment-Test: 05061-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 09:33:30  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 6| 6| 1| 7| 7| 6| 6| 4| 4| 7| 7| 6| 5| 4| 4| 7| 5| 4| 7| 7| 7| 5| 5|             
                             DAY ON TEST   | 5| 3| 4| 1| 5| 3| 3| 4| 3| 6| 5| 3| 0| 1| 0| 5| 5| 0| 5| 6| 3| 3| 1| 8| 7|             
                                           | 8| 0| 8| 8| 2| 0| 0| 7| 3| 4| 7| 0| 9| 1| 1| 8| 8| 6| 0| 0| 0| 0| 7| 2| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    1.0%                                   | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    71LM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Nuclear Alteration                   |                                                                1         |             
      Pigmentation                         | 2  1  1  1  1  1  1  1  2  2  1  1  1  1  1  1  1     1  1  1  1  1  1  1|             
      Bile Duct, Hyperplasia               |                            2                                             |             
      Centrilobular, Cytoplasmic Alteration| 3                                            3  3        3               |             
      Hepatocyte, Centrilobular,           |                                                                          |             
          Hypertrophy                      |                      2     2     2  2  3  2           2     2  2         |             
                                            __________________________________________________________________________|             
   Mesentery                               |                            +                       +                 +   |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         |                                                                      3   |             
      Necrosis, Coagulative                |                                                                          |             
      Thrombosis                           |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Autolysis                            |                                        4                                 |             
      Ectopic Liver                        |                                                                          |             
      Inflammation, Chronic Active         |                      1  1                                   1            |             
      Vacuolization Cytoplasmic            |    1     1                                                        1      |             
      Acinus, Atrophy                      |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Sublingual Gland, Inflammation,      |                                                                          |             
          Chronic                          |                                                                1         |             
      Submandibular Gland, Inflammation,   |                                                                          |             
           Chronic                         |    1  1  2     1  1  1  1  1     1  1  1  1                 1     1      |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |          1                                                               |             
      Acanthosis                           |          1     1                    1        1                           |             
      Cyst                                 |                                                                         1|             
      Diverticulum                         |                                                                          |             
      Hyperkeratosis                       |          1                          1        1                           |             
      Hyperplasia, Basal Cell              |                                              1                           |             
      Inflammation, Chronic Active         |          1     1                                                  1      |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Mast Cell     |                1                                                         |             
      Inflammation, Chronic                | 1                                                        1               |             
      Inflammation, Chronic Active         |    1  1  1        1  1  1           1                       1  1        1|             
      Muscularis, Mineralization           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |    1  1           1  1           1  1              1  3           1      |             
      Necrosis, Coagulative                |                                                       2                  |             
      Coronary Artery, Thrombosis          |                                                       4                  |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  71                                                               
NTP Experiment-Test: 05061-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 09:33:30  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 6| 6| 1| 7| 7| 6| 6| 4| 4| 7| 7| 6| 5| 4| 4| 7| 5| 4| 7| 7| 7| 5| 5|             
                             DAY ON TEST   | 5| 3| 4| 1| 5| 3| 3| 4| 3| 6| 5| 3| 0| 1| 0| 5| 5| 0| 5| 6| 3| 3| 1| 8| 7|             
                                           | 8| 0| 8| 8| 2| 0| 0| 7| 3| 4| 7| 0| 9| 1| 1| 8| 8| 6| 0| 0| 0| 0| 7| 2| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    1.0%                                   | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    71LM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia                          |                                  1  2                                    |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |          2                                                               |             
      Pigmentation                         |                         1                                                |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +     +  +  +  M  +|             
      Hyperplasia                          |                         1                                                |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  M  +  M  +  M  +  M  +     +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  M  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hyperplasia           |          1                 2        1                             1     1|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Ultimobranchial Cyst                 |                                                                          |             
      Follicular Cell, Hyperplasia         |                2                                                         |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                            +                                             |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |    1  1        1     1  1                 2                 1     1      |             
      Epithelium, Hyperplasia              |                                           2                              |             
                                            __________________________________________________________________________|             
   Penis                                   |                                                                          |             
      Hemorrhage                           |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |    +  +  +  +     +     +           +                                +   |             
      Abscess                              |                                                                          |             
      Inflammation, Chronic Active         |    2  2  1        2                 1                                    |             
      Duct, Dilatation                     |          4  2     2     4           2                                4   |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  M  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  I  +  +|             
      Inflammation, Chronic Active         |                1        1  1     1  1     2           1        1     2  1|             
      Inflammation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |          3                                                               |             
      Cyst                                 |                                                                          |             
      Fibrosis                             |    2                                                                     |             
      Inflammation, Chronic Active         |    1     2                       1                             1     1   |             
      Artery, Thrombosis                   |          4                                                               |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Interstitial Cell, Hyperplasia       |                                                                1         |             
      Seminiferous Tubule, Mineralization  |                               1                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  72                                                               
NTP Experiment-Test: 05061-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 09:33:30  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 6| 6| 1| 7| 7| 6| 6| 4| 4| 7| 7| 6| 5| 4| 4| 7| 5| 4| 7| 7| 7| 5| 5|             
                             DAY ON TEST   | 5| 3| 4| 1| 5| 3| 3| 4| 3| 6| 5| 3| 0| 1| 0| 5| 5| 0| 5| 6| 3| 3| 1| 8| 7|             
                                           | 8| 0| 8| 8| 2| 0| 0| 7| 3| 4| 7| 0| 9| 1| 1| 8| 8| 6| 0| 0| 0| 0| 7| 2| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    1.0%                                   | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    71LM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Myeloid Cell, Sternal, Hyperplasia   |                                           3                              |             
      Sternal, Inflammation, Granulomatous |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                      +                             +                     |             
      Lumbar, Hyperplasia, Lymphoid        |                                                                          |             
      Lumbar, Inflammation, Chronic Active |                                                                          |             
      Mediastinal, Infiltration Cellular,  |                                                                          |             
           Histiocyte                      |                                                                          |             
      Mediastinal, Pigmentation            |                                                                          |             
      Renal, Inflammation, Chronic Active  |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  M  M  +  M  +  M  M  M  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +|             
      Depletion Lymphoid                   |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                   2      |             
      Hyperplasia, Plasma Cell             |                                                                   2      |             
      Inflammation, Chronic Active         |                                           3                              |             
      Pigmentation                         |                               1     1                                    |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |    2  1           2                       3                    1         |             
      Congestion                           |          1                                                               |             
      Hematopoietic Cell Proliferation     |    1  1                                                                  |             
      Hyperplasia, Lymphoid                |                2                 1                    2     2  2         |             
      Hyperplasia, Plasma Cell             |                                                                          |             
      Infiltration Cellular, Histiocyte    |    3  1              1  1                                   1  1     1  1|             
      Inflammation, Chronic Active         |                                           4                              |             
      Pigmentation                         |    1  1              1  1                                   1  1     1  1|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Depletion Lymphoid                   |    4                       2                                             |             
      Hematopoietic Cell Proliferation     |                                           4           3                  |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Necrosis, Coagulative                |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  M  M     +  +  +  +  +  +  M     +  +  +  +  +  M|             
      Cyst                                 |                                  2  1                       1     1      |             
      Depletion Lymphoid                   |          4        2                       4                          3   |             
      Infiltration Cellular, Histiocyte    |          2                                                               |             
      Necrosis, Coagulative                |       2                                                                  |             
      Pigmentation                         |          1                                                               |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  M  M  M  M  M  M  M  M  M     M  M  M  M  +  +  M  M  +  M  +  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |    2                             2                                       |             
      Subcutaneous Tissue, Cyst            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  73                                                               
NTP Experiment-Test: 05061-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 09:33:30  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 6| 6| 1| 7| 7| 6| 6| 4| 4| 7| 7| 6| 5| 4| 4| 7| 5| 4| 7| 7| 7| 5| 5|             
                             DAY ON TEST   | 5| 3| 4| 1| 5| 3| 3| 4| 3| 6| 5| 3| 0| 1| 0| 5| 5| 0| 5| 6| 3| 3| 1| 8| 7|             
                                           | 8| 0| 8| 8| 2| 0| 0| 7| 3| 4| 7| 0| 9| 1| 1| 8| 8| 6| 0| 0| 0| 0| 7| 2| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    1.0%                                   | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    71LM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Subcutaneous Tissue, Fibrosis        |                                  2                                       |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  M  +  +  M  +  +  +  +  +|             
      Joint, Tarsal, Hyperostosis          |                4                       4           4           3        4|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                            +                                         +   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Thalamus, Mineralization             |    1  1              1     1     1     1                             1   |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bronchiectasis                       |                                                                          |             
      Crystals                             |                                                                1         |             
      Foreign Body                         |                                                                          |             
      Granuloma                            |                                                                          |             
      Hemorrhage                           |          1                       1                                1      |             
      Infiltration Cellular, Histiocyte    |                                                                2         |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic Active         |                                  1                             1         |             
      Bronchiole, Metaplasia, Squamous     |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                                  1        1                 1     1      |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                   +      |             
      Anterior, Synechia                   |                                                                   1      |             
      Cornea, Fibrosis                     |                                                                   2      |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                   +      |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +|             
      Autolysis                            |                                        2                                 |             
      Congestion                           |                                                                          |             
      Glomerulosclerosis                   |    1                 1                                                   |             
      Infiltration Cellular, Mononuclear   |                                                                          |             
          Cell                             |             1                                                            |             
      Inflammation, Chronic                |                                                 1                        |             
      Inflammation, Chronic Active         |    2  1  2     1  1  1  1  1     1  1  1  1           2     1  1  1      |             
      Necrosis, Coagulative                |                                                                          |             
      Artery, Necrosis, Fibrinoid          |          2                                                               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  74                                                               
NTP Experiment-Test: 05061-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 09:33:30  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 6| 6| 1| 7| 7| 6| 6| 4| 4| 7| 7| 6| 5| 4| 4| 7| 5| 4| 7| 7| 7| 5| 5|             
                             DAY ON TEST   | 5| 3| 4| 1| 5| 3| 3| 4| 3| 6| 5| 3| 0| 1| 0| 5| 5| 0| 5| 6| 3| 3| 1| 8| 7|             
                                           | 8| 0| 8| 8| 2| 0| 0| 7| 3| 4| 7| 0| 9| 1| 1| 8| 8| 6| 0| 0| 0| 0| 7| 2| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    1.0%                                   | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    71LM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Pelvis, Transitional Epithelium,     |                                                                          |             
           Hyperplasia                     |                                                                          |             
      Proximal Convoluted Renal Tubule,    |                                                                          |             
           Hyperplasia                     |                                                    1                     |             
      Proximal Convoluted Renal Tubule,    |                                                                          |             
           Regeneration                    |    1              1  1              1                          1  1      |             
      Renal Tubule, Mineralization         |    1                                                           1         |             
      Renal Tubule, Pigmentation           |    1  1  1     1  1     2  1     1  1  1           1        1  1  1  1   |             
      Renal Tubule, Regeneration           |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                        3                                 |             
      Calculus Micro Observation Only      |                                                                          |             
      Inflammation, Chronic                | 1                                               1        1               |             
      Inflammation, Chronic Active         |    1  1  1     1  1  1  1        2  1  1           1  1     1  1         |             
      Transitional Epithelium, Hyperplasia |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  75                                                               
NTP Experiment-Test: 05061-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 09:33:30  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7| 7| 4| 7| 7| 7| 7| 6|                                            |            |
                             DAY ON TEST   | 3| 5| 3| 1| 1| 3| 3| 3| 3| 4|                                            |            |
                                           | 0| 8| 0| 5| 4| 0| 0| 0| 0| 2|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    1.0%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
    71LM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  56        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +                                             |  56        |
      Autolysis                            |                                                                          |      2  4.0|
      Inflammation, Chronic Active         |       1           1                                                      |     12  1.1|
      Epithelium, Pigmentation             |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +     +  +  +  +                                             |  58        |
      Autolysis                            |                                                                          |      2  3.5|
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Autolysis                            |                                                                          |      2  3.5|
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Autolysis                            |                                                                          |      2  3.5|
      Hemorrhage                           |                                                                          |      1  1.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  1.0|
      Epithelium, Hyperplasia              |                1                                                         |      1  1.0|
      Peyer's Patch, Hyperplasia           |                   2                                                      |      1  2.0|
      Serosa, Inflammation, Chronic Active |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Autolysis                            |                                                                          |      1  4.0|
      Peyer's Patch, Inflammation, Chronic,|                                                                          |            |
           Granulomatous                   |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  56        |
      Autolysis                            |                                                                          |      1  4.0|
      Hyperplasia, Lymphoid                |                            1                                             |      1  1.0|
      Inflammation, Acute                  |                                                                          |      1  1.0|
      Peyer's Patch, Inflammation, Chronic,|                                                                          |            |
           Granulomatous                   |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Autolysis                            |                                                                          |      1  4.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  1.0|
      Peyer's Patch, Hyperplasia           |                                                                          |      2  2.5|
      Peyer's Patch, Inflammation, Chronic,|                                                                          |            |
           Granulomatous                   |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Basophilic Focus                     |                                                                          |      4  1.0|
      Clear Cell Focus                     |                   1  1                                                   |      4  1.0|
      Eosinophilic Focus                   |                                                                          |      6  1.5|
      Fatty Change                         | 1  1           1                                                         |      6  1.2|
      Fibrosis                             |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  76                                                               
NTP Experiment-Test: 05061-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 09:33:30  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7| 7| 4| 7| 7| 7| 7| 6|                                            |            |
                             DAY ON TEST   | 3| 5| 3| 1| 1| 3| 3| 3| 3| 4|                                            |            |
                                           | 0| 8| 0| 5| 4| 0| 0| 0| 0| 2|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    1.0%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
    71LM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Hematopoietic Cell Proliferation     |                                                                          |      5  1.6|
      Inflammation, Acute                  |    1                                                                     |      9  1.0|
      Inflammation, Chronic Active         |       2                                                                  |     10  1.4|
      Mineralization                       |                                                                          |      1  2.0|
      Necrosis, Coagulative                |    1        1                                                            |     20  1.3|
      Nuclear Alteration                   |                                                                          |      1  1.0|
      Pigmentation                         | 1  1  1  1  2  1  2  1  1  1                                             |     59  1.1|
      Bile Duct, Hyperplasia               |                                                                          |      2  2.0|
      Centrilobular, Cytoplasmic Alteration|    3                                                                     |      9  2.9|
      Hepatocyte, Centrilobular,           |                                                                          |            |
          Hypertrophy                      |                            2                                             |     17  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   8        |
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Inflammation, Chronic Active         |                                                                          |      4  2.5|
      Necrosis, Coagulative                |                                                                          |      1  3.0|
      Thrombosis                           |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Autolysis                            |                                                                          |      1  4.0|
      Ectopic Liver                        |                                                                          |      1     |
      Inflammation, Chronic Active         |                      1  1                                                |     12  1.4|
      Vacuolization Cytoplasmic            | 1     1  2  2  1           1                                             |     18  1.3|
      Acinus, Atrophy                      |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Sublingual Gland, Inflammation,      |                                                                          |            |
          Chronic                          |                                                                          |      1  1.0|
      Submandibular Gland, Inflammation,   |                                                                          |            |
           Chronic                         | 1           1  1  1  1  1  1                                             |     29  1.1|
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Abscess                              |                                                                          |      1  1.0|
      Acanthosis                           | 1        1              1                                                |     11  1.1|
      Cyst                                 |                                                                          |      1  1.0|
      Diverticulum                         |                   1                                                      |      1  1.0|
      Hyperkeratosis                       | 1        1              1                                                |      9  1.0|
      Hyperplasia, Basal Cell              |                                                                          |      1  1.0|
      Inflammation, Chronic Active         |                1                                                         |      6  1.2|
      Ulcer                                |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Infiltration Cellular, Mast Cell     |                                                                          |      1  1.0|
      Inflammation, Chronic                |                                                                          |      5  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  77                                                               
NTP Experiment-Test: 05061-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 09:33:30  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7| 7| 4| 7| 7| 7| 7| 6|                                            |            |
                             DAY ON TEST   | 3| 5| 3| 1| 1| 3| 3| 3| 3| 4|                                            |            |
                                           | 0| 8| 0| 5| 4| 0| 0| 0| 0| 2|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    1.0%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
    71LM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Chronic Active         | 1     1              1                                                   |     24  1.1|
      Muscularis, Mineralization           |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Inflammation, Chronic                |       1     1                                                            |     17  1.2|
      Necrosis, Coagulative                |                                                                          |      1  2.0|
      Coronary Artery, Thrombosis          |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hematopoietic Cell Proliferation     |                                                                          |      1  1.0|
      Hyperplasia                          |                      1                                                   |      3  1.3|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Hyperplasia                          |                                                                          |      1  2.0|
      Pigmentation                         |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +     +  +  +  +  +  +  +  +                                             |  50        |
      Hyperplasia                          |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  M  +  +  M                                             |  46        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | M  +  +  +  +  +  +  +  +  +                                             |  54        |
      Pars Distalis, Cyst                  |                   1                                                      |      4  1.3|
      Pars Distalis, Hyperplasia           |             2                                                            |      9  1.2|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Inflammation, Chronic                |                   1                                                      |      1  1.0|
      Ultimobranchial Cyst                 |                   1                                                      |      1  1.0|
      Follicular Cell, Hyperplasia         |                                                                          |      3  1.3|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Coagulating Gland                       |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Inflammation, Chronic Active         | 1           1     1     1                                                |     21  1.0|
      Epithelium, Hyperplasia              |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Penis                                   |                                                                          |   1        |
      Hemorrhage                           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |             +  +     +     +                                             |  16        |
      Abscess                              |                4     4     4                                             |      3  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  78                                                               
NTP Experiment-Test: 05061-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 09:33:30  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7| 7| 4| 7| 7| 7| 7| 6|                                            |            |
                             DAY ON TEST   | 3| 5| 3| 1| 1| 3| 3| 3| 3| 4|                                            |            |
                                           | 0| 8| 0| 5| 4| 0| 0| 0| 0| 2|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    1.0%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
    71LM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Chronic Active         |             1                                                            |      7  1.4|
      Duct, Dilatation                     |                                                                          |     10  3.0|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +                                             |  55        |
      Inflammation, Chronic Active         | 1     1  1  1  1     1  2                                                |     29  1.1|
      Inflammation                         |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Atrophy                              |                                                                          |      1  3.0|
      Cyst                                 |                                                                          |      1  2.0|
      Fibrosis                             |                            1                                             |      3  1.7|
      Inflammation, Chronic Active         |       1           1     1                                                |     14  1.1|
      Artery, Thrombosis                   |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Interstitial Cell, Hyperplasia       |                                                                          |      1  1.0|
      Seminiferous Tubule, Mineralization  |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Myeloid Cell, Sternal, Hyperplasia   |                                                                          |      2  3.5|
      Sternal, Inflammation, Granulomatous |                            2                                             |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                            +                                             |   8        |
      Lumbar, Hyperplasia, Lymphoid        |                                                                          |      1  2.0|
      Lumbar, Inflammation, Chronic Active |                                                                          |      1  1.0|
      Mediastinal, Infiltration Cellular,  |                                                                          |            |
           Histiocyte                      |                                                                          |      1     |
      Mediastinal, Pigmentation            |                                                                          |      1  1.0|
      Renal, Inflammation, Chronic Active  |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  M  +  +  +  +  +  +                                             |  43        |
      Depletion Lymphoid                   |                                                                          |      1  3.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
      Hyperplasia, Plasma Cell             |                                                                          |      1  2.0|
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
      Pigmentation                         |                                                                          |      4  1.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  M  +  +  +                                             |  56        |
      Angiectasis                          |                         1                                                |     11  1.5|
      Congestion                           |                                                                          |      1  1.0|
      Hematopoietic Cell Proliferation     |                                                                          |      2  1.0|
      Hyperplasia, Lymphoid                | 2              1        1                                                |      9  1.9|
      Hyperplasia, Plasma Cell             |                                                                          |      1  3.0|
      Infiltration Cellular, Histiocyte    | 1     1              1  1                                                |     22  1.1|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  79                                                               
NTP Experiment-Test: 05061-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 09:33:30  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7| 7| 4| 7| 7| 7| 7| 6|                                            |            |
                             DAY ON TEST   | 3| 5| 3| 1| 1| 3| 3| 3| 3| 4|                                            |            |
                                           | 0| 8| 0| 5| 4| 0| 0| 0| 0| 2|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    1.0%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
    71LM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Chronic Active         |                                                                          |      7  2.6|
      Pigmentation                         | 1     1              1  1                                                |     22  1.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Depletion Lymphoid                   |          1                                                               |      3  2.3|
      Hematopoietic Cell Proliferation     |             3        2     3                                             |     14  3.0|
      Hyperplasia, Lymphoid                |                   2  1                                                   |      2  1.5|
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Necrosis, Coagulative                |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  M  M  +  +  +  M  +                                             |  44        |
      Cyst                                 |       1        1                                                         |      6  1.2|
      Depletion Lymphoid                   |                                                                          |      8  3.0|
      Infiltration Cellular, Histiocyte    |                                                                          |      1  2.0|
      Necrosis, Coagulative                |                                                                          |      1  2.0|
      Pigmentation                         |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  +  M  M  M  M  M  M  M  M                                             |  10        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  M  +  +  +  +  +                                             |  57        |
      Inflammation, Chronic Active         |                1  1                                                      |      9  1.4|
      Subcutaneous Tissue, Cyst            |                                                                          |      1  2.0|
      Subcutaneous Tissue, Fibrosis        |                                                                          |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  52        |
      Joint, Tarsal, Hyperostosis          |    4        4     3     4                                                |     13  3.7|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   3        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Thalamus, Mineralization             |       1        1        1                                                |     20  1.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Bronchiectasis                       |          1                                                               |      1  1.0|
      Crystals                             |                                                                          |      1  1.0|
      Foreign Body                         |                                                                          |      1  1.0|
      Granuloma                            |                                                                          |      1  1.0|
      Hemorrhage                           |                1                                                         |      9  1.1|
      Infiltration Cellular, Histiocyte    |          4                                                               |      2  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  80                                                               
NTP Experiment-Test: 05061-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 09:33:30  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7| 7| 4| 7| 7| 7| 7| 6|                                            |            |
                             DAY ON TEST   | 3| 5| 3| 1| 1| 3| 3| 3| 3| 4|                                            |            |
                                           | 0| 8| 0| 5| 4| 0| 0| 0| 0| 2|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    1.0%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
    71LM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Acute                  |          2                                                               |      2  1.5|
      Inflammation, Chronic Active         |                                                                          |      3  1.3|
      Bronchiole, Metaplasia, Squamous     |          2                                                               |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Inflammation, Acute                  | 1        1                                                               |     11  1.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  59        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
      Anterior, Synechia                   |                                                                          |      1  1.0|
      Cornea, Fibrosis                     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  M  +  +  +  +  +  +  +  +                                             |  52        |
      Autolysis                            |                                                                          |      1  2.0|
      Congestion                           |                         1                                                |      1  1.0|
      Glomerulosclerosis                   |                                                                          |      3  1.0|
      Infiltration Cellular, Mononuclear   |                                                                          |            |
          Cell                             |                                                                          |      1  1.0|
      Inflammation, Chronic                |                                                                          |      1  1.0|
      Inflammation, Chronic Active         | 2     1  1  1  1  1  1  2                                                |     42  1.2|
      Necrosis, Coagulative                |                                                                          |      1  1.0|
      Artery, Necrosis, Fibrinoid          |                                                                          |      1  2.0|
      Pelvis, Transitional Epithelium,     |                                                                          |            |
           Hyperplasia                     |                            3                                             |      1  3.0|
      Proximal Convoluted Renal Tubule,    |                                                                          |            |
           Hyperplasia                     |                                                                          |      1  1.0|
      Proximal Convoluted Renal Tubule,    |                                                                          |            |
           Regeneration                    | 1        1     1  1  1                                                   |     11  1.0|
      Renal Tubule, Mineralization         |                                                                          |      4  1.0|
      Renal Tubule, Pigmentation           | 1     1  1  1  1  1  2  1  1                                             |     42  1.1|
      Renal Tubule, Regeneration           |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Autolysis                            |                                                                          |      3  3.0|
      Calculus Micro Observation Only      |                                                                          |      2  2.0|
      Inflammation, Chronic                |                                                                          |      7  1.0|
      Inflammation, Chronic Active         | 1     1  1     1        1                                                |     31  1.0|
      Transitional Epithelium, Hyperplasia |                                                                          |      2  1.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  81                                                               
NTP Experiment-Test: 05061-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 09:33:30  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 7| 6| 5| 4| 1| 4| 7| 7| 7| 7| 6| 7| 4| 7| 6| 6| 7| 7| 4| 6| 6|             
                             DAY ON TEST   | 5| 2| 2| 2| 2| 4| 9| 8| 3| 5| 2| 2| 2| 2| 1| 2| 5| 2| 8| 4| 2| 2| 6| 2| 0|             
                                           | 8| 9| 9| 9| 9| 8| 3| 4| 6| 8| 9| 9| 9| 9| 3| 9| 8| 9| 9| 5| 9| 9| 0| 1| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    2.0%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    71HM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  M  +  +  M  +  +  +|             
      Inflammation, Chronic                |                                                                   1      |             
      Inflammation, Chronic Active         |                      1           1  1                                1   |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mesothelium, Hyperplasia             |                      1                                                   |             
      Serosa, Fibrosis                     |                      2                                                   |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Epithelium, Pigmentation             |                      1                                                   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Peyer's Patch, Hyperplasia           |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus, Focal              |                                  2                                       |             
      Basophilic Focus                     | 1     1  1                                                               |             
      Clear Cell Focus                     |                                                    1                     |             
      Eosinophilic Focus                   |                                                    1                     |             
      Fatty Change                         |       1  1  2                    1                                       |             
      Hematopoietic Cell Proliferation     |                                     1  1                                 |             
      Infarct                              |                                                       4                  |             
      Inflammation, Acute                  | 1                          1                                             |             
      Inflammation, Chronic Active         |          2        1           1  1  1  1                    1  2  2      |             
      Karyomegaly                          |          3                                                               |             
      Necrosis, Coagulative                | 2        1  1  1  1  1     1  1        2  1           2  1        1      |             
      Pigmentation                         | 1  1  1  2  2  2  2  1     1  1  1  1  2  1  1  1  1  2  1  1  2  1  1  2|             
      Thrombosis                           |                                              1                           |             
      Bile Duct, Hyperplasia               |                                                                          |             
      Centrilobular, Cytoplasmic Alteration| 3                                               3                        |             
      Hepatocyte, Centrilobular,           |                                                                          |             
          Hypertrophy                      |                2  3  2        1  2                                   2   |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                           +                              |             
      Abscess                              |                                                                          |             
      Fibrosis                             |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Mineralization                       |                                                                          |             
      Necrosis, Coagulative                |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                            1                                             |             
      Cytoplasmic Alteration               |                                                                          |             
      Inflammation, Chronic Active         |                      1                                      1            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  82                                                               
NTP Experiment-Test: 05061-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 09:33:30  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 7| 6| 5| 4| 1| 4| 7| 7| 7| 7| 6| 7| 4| 7| 6| 6| 7| 7| 4| 6| 6|             
                             DAY ON TEST   | 5| 2| 2| 2| 2| 4| 9| 8| 3| 5| 2| 2| 2| 2| 1| 2| 5| 2| 8| 4| 2| 2| 6| 2| 0|             
                                           | 8| 9| 9| 9| 9| 8| 3| 4| 6| 8| 9| 9| 9| 9| 3| 9| 8| 9| 9| 5| 9| 9| 0| 1| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    2.0%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    71HM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Vacuolization Cytoplasmic            |                2                                                         |             
      Artery, Inflammation, Chronic Active |                            4                                             |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Duct, Parotid Gland, Mineralization  |                                              1                           |             
      Sublingual Gland, Submandibular      |                                                                          |             
          Gland, Inflammation, Chronic     |                               1                                          |             
      Submandibular Gland, Atrophy         |                                                                      1   |             
      Submandibular Gland, Inflammation,   |                                                                          |             
           Chronic                         | 1  1  2  2  1  1     1           1  1  1  1        2  1  1  1  2     1  1|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                      1                       2                 2  2  3   |             
      Hyperkeratosis                       |                      2                       1                 2  1  2   |             
      Hyperplasia, Basal Cell              |                                                                2         |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic Active         |       1     1                    2           1                 2  2  1   |             
      Inflammation, Chronic Active,        |                                                                          |             
          Necrotizing                      |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                   1                                                      |             
      Inflammation, Chronic                |                            1                                             |             
      Inflammation, Chronic Active         |    1     1  1     1           1  1  2  1     1     1              2  1   |             
      Mineralization                       |       1                                                                  |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |    +        +                             +  +                           |             
      Dysplasia                            |    1        2                                1                           |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |                            1                                             |             
      Inflammation, Chronic                |                               1        1                                 |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |             2                                                            |             
      Vacuolization Cytoplasmic            |                                                                          |             
      Capsule, Inflammation, Chronic Active|                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +  +  +  +  +  +  +  +  +  +  +  +  +  M  +     +  +  +  +  +     +  +|             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic                |                            1                                             |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  M  +  +  +  +  M  +  M  +  +  +  M  +  M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +|             
      Pars Distalis, Cyst                  |                                                                1         |             
      Pars Distalis, Hyperplasia           |                      1     2              1        1                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  83                                                               
NTP Experiment-Test: 05061-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 09:33:30  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 7| 6| 5| 4| 1| 4| 7| 7| 7| 7| 6| 7| 4| 7| 6| 6| 7| 7| 4| 6| 6|             
                             DAY ON TEST   | 5| 2| 2| 2| 2| 4| 9| 8| 3| 5| 2| 2| 2| 2| 1| 2| 5| 2| 8| 4| 2| 2| 6| 2| 0|             
                                           | 8| 9| 9| 9| 9| 8| 3| 4| 6| 8| 9| 9| 9| 9| 3| 9| 8| 9| 9| 5| 9| 9| 0| 1| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    2.0%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    71HM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Follicle, Cyst                       |                                                                          |             
      Follicular Cell, Hyperplasia         |       2                                                     1            |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                               +                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |    1  1  1     1  1           1        1     1     1                     |             
      Serosa, Hyperplasia                  |                                                                          |             
                                            __________________________________________________________________________|             
   Penis                                   |             +                                                            |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |       +                    +  +  +                       +              +|             
      Abscess                              |                            4                             3               |             
      Inflammation, Chronic Active         |       2                       1  2                       2               |             
      Duct, Dilatation                     |       2                       2                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         |    1  1  1     1                             1        1     1            |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Inflammation, Chronic Active         |       1        1  1           1                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                   1      |             
      Inflammation, Chronic Active         |                                                                          |             
      Seminiferous Tubule, Atrophy         |    1                       1                                             |             
      Seminiferous Tubule, Mineralization  |    1                                                                 1   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Myeloid Cell, Sternal, Hyperplasia   |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                         +        +        +                             +|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Lumbar, Hyperplasia, Plasma Cell     |                         2                                                |             
      Mediastinal, Inflammation, Chronic   |                                                                          |             
          Active                           |                                                                          |             
      Pancreatic, Angiectasis              |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  M  M  +  M  +  M  M  +  M  +  +  +  M  M  +  M  +  +  +  M|             
      Depletion Lymphoid                   |                                           4                              |             
      Hyperplasia, Lymphoid                |                                                                2         |             
      Infiltration Cellular, Histiocyte    |    1        1                                                  1         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  84                                                               
NTP Experiment-Test: 05061-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 09:33:30  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 7| 6| 5| 4| 1| 4| 7| 7| 7| 7| 6| 7| 4| 7| 6| 6| 7| 7| 4| 6| 6|             
                             DAY ON TEST   | 5| 2| 2| 2| 2| 4| 9| 8| 3| 5| 2| 2| 2| 2| 1| 2| 5| 2| 8| 4| 2| 2| 6| 2| 0|             
                                           | 8| 9| 9| 9| 9| 8| 3| 4| 6| 8| 9| 9| 9| 9| 3| 9| 8| 9| 9| 5| 9| 9| 0| 1| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    2.0%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    71HM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Necrosis, Coagulative                |                                                                          |             
      Pigmentation                         |    1        1                                                  1         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |    1  2  1                             2           2     2     2        2|             
      Depletion Lymphoid                   |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                  3                                       |             
      Hyperplasia                          |                                                                          |             
      Infiltration Cellular, Histiocyte    |          1                    1     1  1     1     1  1     1        1   |             
      Inflammation, Chronic Active         |                                                                          |             
      Pigmentation                         |          1                    1     1  1     1     1  1     1        1   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Depletion Lymphoid                   |                                                       1                  |             
      Fibrosis                             |                                                                2         |             
      Hematopoietic Cell Proliferation     |          2           4                                   2              2|             
      Hyperplasia, Lymphoid                |                                                                2         |             
      Inflammation, Chronic Active         |                                                                2         |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  M  +  M  +  M  M  +  +  +  +  +  +  +  M  +  +  M  +  I  +  +  +|             
      Cyst                                 |    1                                1     1                       1     1|             
      Depletion Lymphoid                   |                                           2           4                 4|             
      Necrosis, Coagulative                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  M  M  M  M  M  M  M  M  +  M  M  M  M  M  M  +  M  M  M  M  M  +  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |       1                                2     1     1        1            |             
      Subcutaneous Tissue, Abscess         |                                                                          |             
      Subcutaneous Tissue, Fibrosis        |                                                                          |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic Active                  | 1                                                                        |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Joint, Tarsal, Hyperostosis          |          4     4                                            2        4   |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                           +                              |             
      Intercostal, Inflammation, Chronic   |                                                                          |             
          Active                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                         2                                                |             
      Thalamus, Mineralization             | 1        1                 1     1                 1              1     1|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  85                                                               
NTP Experiment-Test: 05061-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 09:33:30  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 7| 6| 5| 4| 1| 4| 7| 7| 7| 7| 6| 7| 4| 7| 6| 6| 7| 7| 4| 6| 6|             
                             DAY ON TEST   | 5| 2| 2| 2| 2| 4| 9| 8| 3| 5| 2| 2| 2| 2| 1| 2| 5| 2| 8| 4| 2| 2| 6| 2| 0|             
                                           | 8| 9| 9| 9| 9| 8| 3| 4| 6| 8| 9| 9| 9| 9| 3| 9| 8| 9| 9| 5| 9| 9| 0| 1| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    2.0%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    71HM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                         1                                                |             
      Hemorrhage                           |             2                                      1                     |             
      Infiltration Cellular, Histiocyte    |                2                                            1            |             
      Inflammation, Chronic Active         |                                                                          |             
      Pigmentation                         |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |          1     1                    1                    2               |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                                                                          |             
      Glands, Inflammation, Acute          |                                                 1                        |             
      Respiratory Epithelium, Necrosis     |                            1                                             |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                                                    2           1         |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                     +                                    |             
                                            __________________________________________________________________________|             
   Lacrimal Gland                          |                                                                   +      |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                           2                              |             
      Inflammation, Acute, Necrotizing     |                                                                          |             
      Inflammation, Chronic                | 1                          1                                      1      |             
      Inflammation, Chronic Active         |    1  1  2  1  1  1  1        1  1  1  1  1  1     1  1  1  1  2     1  1|             
      Metaplasia, Osseous                  |                                                                          |             
      Mineralization                       |                                                                          |             
      Proximal Convoluted Renal Tubule,    |                                                                          |             
           Regeneration                    |                                                                          |             
      Renal Tubule, Mineralization         |                         1                                                |             
      Renal Tubule, Pigmentation           |    2  1  1  1  1  1           2  1     2  1  1     1  1  2     2     1  1|             
      Renal Tubule, Regeneration           |                                                                   1      |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                | 1                                               1                 1      |             
      Inflammation, Chronic Active         |    1  2  1     1  1           1  1  1  1           1  1  1     1         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  86                                                               
NTP Experiment-Test: 05061-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 09:33:30  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 7| 6| 7| 7| 7| 7| 5| 5| 7| 7| 6| 5| 7| 4| 6| 6| 2| 7| 4| 7| 6| 5|             
                             DAY ON TEST   | 2| 6| 2| 2| 9| 2| 2| 2| 2| 2| 1| 2| 0| 6| 3| 2| 6| 6| 1| 4| 2| 5| 2| 3| 1|             
                                           | 9| 0| 9| 6| 6| 9| 9| 9| 9| 3| 7| 9| 9| 2| 5| 9| 0| 5| 8| 8| 9| 8| 4| 3| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    2.0%                                   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    71HM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  M|             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         |             1           2                    1                    2      |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |             2                    2                                       |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Mesothelium, Hyperplasia             |                                                                          |             
      Serosa, Fibrosis                     |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Epithelium, Pigmentation             |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |             2                                                            |             
      Peyer's Patch, Hyperplasia           |                         2                                                |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus, Focal              |                                                                          |             
      Basophilic Focus                     |                               1                                          |             
      Clear Cell Focus                     |                         1                                                |             
      Eosinophilic Focus                   |                                                                          |             
      Fatty Change                         |          1                 4                                1            |             
      Hematopoietic Cell Proliferation     |             2              1     2     1     1        1           1      |             
      Infarct                              |                                                                          |             
      Inflammation, Acute                  |                                                                1         |             
      Inflammation, Chronic Active         |                1     2  1        2  1  1  1  1  1  1        1     2      |             
      Karyomegaly                          |                                                                          |             
      Necrosis, Coagulative                |                1     1     1     1              1        2     1  1     1|             
      Pigmentation                         | 2  1  2  2  2  1  1  1  2  1  1  2  1  1  1     2  2  1  2  2  1  2  2  1|             
      Thrombosis                           |                                                                          |             
      Bile Duct, Hyperplasia               |                      2                                                   |             
      Centrilobular, Cytoplasmic Alteration|    2                                            3              3         |             
      Hepatocyte, Centrilobular,           |                                                                          |             
          Hypertrophy                      |                                     2     2           2     2        2   |             
                                            __________________________________________________________________________|             
   Mesentery                               |             +           +              +           +     +        +      |             
      Abscess                              |                                        4                                 |             
      Fibrosis                             |                                                                          |             
      Inflammation, Chronic Active         |             3           3                          2              2      |             
      Mineralization                       |                                                                          |             
      Necrosis, Coagulative                |                                                          3               |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Atrophy                              |                                                                          |             
      Cytoplasmic Alteration               |    2                                               2                     |             
      Inflammation, Chronic Active         |          1  2           3  1           1  1                              |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  87                                                               
NTP Experiment-Test: 05061-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 09:33:30  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 7| 6| 7| 7| 7| 7| 5| 5| 7| 7| 6| 5| 7| 4| 6| 6| 2| 7| 4| 7| 6| 5|             
                             DAY ON TEST   | 2| 6| 2| 2| 9| 2| 2| 2| 2| 2| 1| 2| 0| 6| 3| 2| 6| 6| 1| 4| 2| 5| 2| 3| 1|             
                                           | 9| 0| 9| 6| 6| 9| 9| 9| 9| 3| 7| 9| 9| 2| 5| 9| 0| 5| 8| 8| 9| 8| 4| 3| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    2.0%                                   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    71HM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Vacuolization Cytoplasmic            |                                        2              2                 1|             
      Artery, Inflammation, Chronic Active |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Duct, Parotid Gland, Mineralization  |                                                                          |             
      Sublingual Gland, Submandibular      |                                                                          |             
          Gland, Inflammation, Chronic     |                                                                          |             
      Submandibular Gland, Atrophy         |                                                                          |             
      Submandibular Gland, Inflammation,   |                                                                          |             
           Chronic                         | 1     1  2        2  1     1  1  2  1  1     1     1  1     1  1         |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                                 2              2         |             
      Hyperkeratosis                       | 1                          3                    3              2         |             
      Hyperplasia, Basal Cell              | 1                                                              1         |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic Active         | 1        1              1        1           2  3                        |             
      Inflammation, Chronic Active,        |                                                                          |             
          Necrotizing                      |             4                                                            |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Edema                                |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         | 1        1        1  1  1  1                 1        1     2           1|             
      Mineralization                       |                   1                                                      |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                          +               |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                        +                                 |             
      Dysplasia                            |                                        1                                 |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |                                                                          |             
      Inflammation, Chronic                |                      1                                                   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                               1                                          |             
      Vacuolization Cytoplasmic            |                                                                          |             
      Capsule, Inflammation, Chronic Active|                                        2                                 |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     M  +  +|             
      Hyperplasia                          |                                                                      1   |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  M  +  +  M  +  +  +  M  M  +  +  +  +  +  M  +  +  +  +  M  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hyperplasia           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  88                                                               
NTP Experiment-Test: 05061-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 09:33:30  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 7| 6| 7| 7| 7| 7| 5| 5| 7| 7| 6| 5| 7| 4| 6| 6| 2| 7| 4| 7| 6| 5|             
                             DAY ON TEST   | 2| 6| 2| 2| 9| 2| 2| 2| 2| 2| 1| 2| 0| 6| 3| 2| 6| 6| 1| 4| 2| 5| 2| 3| 1|             
                                           | 9| 0| 9| 6| 6| 9| 9| 9| 9| 3| 7| 9| 9| 2| 5| 9| 0| 5| 8| 8| 9| 8| 4| 3| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    2.0%                                   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    71HM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Follicle, Cyst                       |                                                                          |             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         | 1     1     2  1  1     1              2     1     1  1     1     1  1   |             
      Serosa, Hyperplasia                  |                                        1                                 |             
                                            __________________________________________________________________________|             
   Penis                                   |                                              +                           |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +                 M                 +                 +              +   |             
      Abscess                              |                                                                          |             
      Inflammation, Chronic Active         | 2                                   2                 2              1   |             
      Duct, Dilatation                     |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                 2                        |             
      Inflammation, Chronic Active         |       1     2        1  1           1  2  1        1        1     1  1   |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  M  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  M  +   |             
      Atrophy                              |                                           3                              |             
      Inflammation, Chronic Active         |       1     1  1        1  1     1     1           1                 1   |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Inflammation, Chronic Active         |          1  1                                                            |             
      Seminiferous Tubule, Atrophy         |                                                    1                     |             
      Seminiferous Tubule, Mineralization  |                                                    1                     |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Myeloid Cell, Sternal, Hyperplasia   |                                        4                                 |             
                                            __________________________________________________________________________|             
   Lymph Node                              |             +           +        +                 +                     |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Lumbar, Hyperplasia, Plasma Cell     |             4                                                            |             
      Mediastinal, Inflammation, Chronic   |                                                                          |             
          Active                           |                                                                          |             
      Pancreatic, Angiectasis              |                                                    3                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  M  I  M  M  M  M  M  +  M  M  +  +  +  +  +  +  +  +  M  +|             
      Depletion Lymphoid                   |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Infiltration Cellular, Histiocyte    |       1                             1                       1     1      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  89                                                               
NTP Experiment-Test: 05061-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 09:33:30  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 7| 6| 7| 7| 7| 7| 5| 5| 7| 7| 6| 5| 7| 4| 6| 6| 2| 7| 4| 7| 6| 5|             
                             DAY ON TEST   | 2| 6| 2| 2| 9| 2| 2| 2| 2| 2| 1| 2| 0| 6| 3| 2| 6| 6| 1| 4| 2| 5| 2| 3| 1|             
                                           | 9| 0| 9| 6| 6| 9| 9| 9| 9| 3| 7| 9| 9| 2| 5| 9| 0| 5| 8| 8| 9| 8| 4| 3| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    2.0%                                   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    71HM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Necrosis, Coagulative                |                                                          1               |             
      Pigmentation                         |       1                             1        1              1     1      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Angiectasis                          |          1  3           1  3  2        2  1  2     3  2                  |             
      Depletion Lymphoid                   |                                                                      3   |             
      Hemorrhage                           |                            4                                   2         |             
      Hyperplasia, Lymphoid                |       3                          2                                       |             
      Hyperplasia                          |                         2                                                |             
      Infiltration Cellular, Histiocyte    | 1     1  1     1  1  1  1           1  1  1  1                       1   |             
      Inflammation, Chronic Active         |                                  2     2              2                  |             
      Pigmentation                         | 1     1  1     1     1  1           1  1     1                       1   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                          2               |             
      Depletion Lymphoid                   |                            2                          4                  |             
      Fibrosis                             |                                                                          |             
      Hematopoietic Cell Proliferation     |             4           3              2  1           4           2      |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Inflammation, Chronic Active         |             4                                                            |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  M  +  M  M  +  +  M  M  +  M  M  +  M  +  +  +  +  +  M  M  +|             
      Cyst                                 |       1  1                                            1     1            |             
      Depletion Lymphoid                   |                            3                       3  4                  |             
      Necrosis, Coagulative                |                                                          3               |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  +  M  M  M  M  M  M  M  M  M  M  M  M  M  M  +  M  M  M  M  +  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Inflammation, Chronic Active         | 1        1     1  1                    1  1                              |             
      Subcutaneous Tissue, Abscess         |                                                       2                  |             
      Subcutaneous Tissue, Fibrosis        |                   2                                                      |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic Active                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Joint, Tarsal, Hyperostosis          |       4        3     2  4                                   4        4   |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                    +                     |             
      Intercostal, Inflammation, Chronic   |                                                                          |             
          Active                           |                                                    2                     |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                                                          |             
      Thalamus, Mineralization             |    1     1              1        1  1        1  1           1  1         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  90                                                               
NTP Experiment-Test: 05061-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 09:33:30  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 7| 6| 7| 7| 7| 7| 5| 5| 7| 7| 6| 5| 7| 4| 6| 6| 2| 7| 4| 7| 6| 5|             
                             DAY ON TEST   | 2| 6| 2| 2| 9| 2| 2| 2| 2| 2| 1| 2| 0| 6| 3| 2| 6| 6| 1| 4| 2| 5| 2| 3| 1|             
                                           | 9| 0| 9| 6| 6| 9| 9| 9| 9| 3| 7| 9| 9| 2| 5| 9| 0| 5| 8| 8| 9| 8| 4| 3| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    2.0%                                   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    71HM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hemorrhage                           |                1        1           1                       1  1     1   |             
      Infiltration Cellular, Histiocyte    |             1                          1                                 |             
      Inflammation, Chronic Active         |                                                                          |             
      Pigmentation                         |                                                                         1|             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Inflammation, Acute                  |             1        1                       1        2           2     1|             
      Glands, Inflammation, Acute          |                                                 1                        |             
      Respiratory Epithelium, Necrosis     |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |       1                                                                  |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                             +            |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
                                            __________________________________________________________________________|             
   Lacrimal Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Inflammation, Acute, Necrotizing     |             3                                                            |             
      Inflammation, Chronic                |    1                                                           1         |             
      Inflammation, Chronic Active         | 1     2  2  3  1  1  1  1  1  1  1  1  1  1  2     1  1     1     1  1  1|             
      Metaplasia, Osseous                  |                      1                                                   |             
      Mineralization                       |                                        1                                 |             
      Proximal Convoluted Renal Tubule,    |                                                                          |             
           Regeneration                    |                         1                                                |             
      Renal Tubule, Mineralization         |                                                                          |             
      Renal Tubule, Pigmentation           | 1     2  2  1  1  2  2  1  1  1  1  1  1  2  1     1  1  1  1     1  1  1|             
      Renal Tubule, Regeneration           |    1                                            1                        |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                 1              1         |             
      Inflammation, Chronic Active         | 1     1  1  1  1  2     1  1  1  1     2  1  1     1  1           1  1  1|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  91                                                               
NTP Experiment-Test: 05061-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 09:33:30  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 4| 4| 2| 1| 7| 7| 4| 7| 6|                                            |            |
                             DAY ON TEST   | 8| 5| 5| 4| 0| 2| 2| 5| 2| 1|                                            |            |
                                           | 9| 8| 8| 9| 9| 9| 9| 8| 2| 8|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    2.0%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
    71HM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  A  +  +  +  +  M                                             |  51        |
      Inflammation, Chronic                |                                                                          |      1  1.0|
      Inflammation, Chronic Active         |                                                                          |      8  1.3|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Inflammation, Chronic Active         |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +                                             |  58        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  M  +  +  +  +  +                                             |  56        |
      Mesothelium, Hyperplasia             |                                                                          |      1  1.0|
      Serosa, Fibrosis                     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  A  +  +  +  +  +                                             |  58        |
      Epithelium, Pigmentation             |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  M  +  +  +  +  +                                             |  57        |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Peyer's Patch, Hyperplasia           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Basophilic Focus, Focal              |                                                                          |      1  2.0|
      Basophilic Focus                     |                                                                          |      4  1.0|
      Clear Cell Focus                     |                                                                          |      2  1.0|
      Eosinophilic Focus                   |                                                                          |      1  1.0|
      Fatty Change                         |                                                                          |      7  1.6|
      Hematopoietic Cell Proliferation     | 3                                                                        |     10  1.4|
      Infarct                              |                                                                          |      1  4.0|
      Inflammation, Acute                  |                                                                          |      3  1.0|
      Inflammation, Chronic Active         |    1  1           1  1  2  1                                             |     27  1.3|
      Karyomegaly                          |                                                                          |      1  3.0|
      Necrosis, Coagulative                |    1  1        1  1  1  1                                                |     28  1.1|
      Pigmentation                         | 2  1  2  1     1  1  1  1  2                                             |     57  1.4|
      Thrombosis                           |                                                                          |      1  1.0|
      Bile Duct, Hyperplasia               |                                                                          |      1  2.0|
      Centrilobular, Cytoplasmic Alteration|    3  3              3                                                   |      8  2.9|
      Hepatocyte, Centrilobular,           |                                                                          |            |
          Hypertrophy                      |             2              2                                             |     13  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                +        +                                                |   9        |
      Abscess                              |                                                                          |      1  4.0|
      Fibrosis                             |                1                                                         |      1  1.0|
      Inflammation, Chronic Active         |                         3                                                |      5  2.6|
      Mineralization                       |                1                                                         |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  92                                                               
NTP Experiment-Test: 05061-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 09:33:30  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 4| 4| 2| 1| 7| 7| 4| 7| 6|                                            |            |
                             DAY ON TEST   | 8| 5| 5| 4| 0| 2| 2| 5| 2| 1|                                            |            |
                                           | 9| 8| 8| 9| 9| 9| 9| 8| 2| 8|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    2.0%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
    71HM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Necrosis, Coagulative                |                3                                                         |      2  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Atrophy                              |                                                                          |      1  1.0|
      Cytoplasmic Alteration               |                                                                          |      2  2.0|
      Inflammation, Chronic Active         |                                                                          |      8  1.4|
      Vacuolization Cytoplasmic            |                                                                          |      4  1.8|
      Artery, Inflammation, Chronic Active |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Duct, Parotid Gland, Mineralization  |                                                                          |      1  1.0|
      Sublingual Gland, Submandibular      |                                                                          |            |
          Gland, Inflammation, Chronic     |                                                                          |      1  1.0|
      Submandibular Gland, Atrophy         |                                                                          |      1  1.0|
      Submandibular Gland, Inflammation,   |                                                                          |            |
           Chronic                         | 1     1        1  1  1  2  1                                             |     40  1.2|
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Acanthosis                           |                                                                          |      7  2.0|
      Hyperkeratosis                       |                                                                          |      9  1.9|
      Hyperplasia, Basal Cell              |                                                                          |      3  1.3|
      Inflammation, Acute                  |       1                                                                  |      1  1.0|
      Inflammation, Chronic Active         |                         2                                                |     14  1.5|
      Inflammation, Chronic Active,        |                                                                          |            |
          Necrotizing                      |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Edema                                |                                                                          |      1  1.0|
      Inflammation, Chronic                |       1                                                                  |      2  1.0|
      Inflammation, Chronic Active         |                1                                                         |     23  1.1|
      Mineralization                       | 1                                                                        |      3  1.0|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                   +     +                                                |   7        |
      Dysplasia                            |                   1     1                                                |      6  1.2|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cardiomyopathy                       |                                                                          |      1  1.0|
      Inflammation, Chronic                |                1        1                                                |      5  1.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperplasia                          |                                                                          |      2  1.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  93                                                               
NTP Experiment-Test: 05061-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 09:33:30  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 4| 4| 2| 1| 7| 7| 4| 7| 6|                                            |            |
                             DAY ON TEST   | 8| 5| 5| 4| 0| 2| 2| 5| 2| 1|                                            |            |
                                           | 9| 8| 8| 9| 9| 9| 9| 8| 2| 8|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    2.0%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
    71HM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Vacuolization Cytoplasmic            | 2                                                                        |      1  2.0|
      Capsule, Inflammation, Chronic Active|                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +        +  +  +  +     +  +                                             |  49        |
      Hyperplasia                          |                                                                          |      1  1.0|
      Inflammation, Chronic                |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  M  +                                             |  48        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  56        |
      Pars Distalis, Cyst                  |                                                                          |      1  1.0|
      Pars Distalis, Hyperplasia           |       1           1                                                      |      6  1.2|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  M  +                                             |  59        |
      Inflammation, Chronic                |                   1                                                      |      1  1.0|
      Follicle, Cyst                       |                      1                                                   |      1  1.0|
      Follicular Cell, Hyperplasia         | 1                                                                        |      3  1.3|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Coagulating Gland                       |                         +                                                |   1        |
      Inflammation, Chronic Active         |                         2                                                |      1  2.0|
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Inflammation, Chronic Active         |                1  1     3  1                                             |     26  1.2|
      Serosa, Hyperplasia                  |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Penis                                   |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                +  +     +                                                |  13        |
      Abscess                              |                                                                          |      2  3.5|
      Inflammation, Chronic Active         |                4  2     2                                                |     11  2.0|
      Duct, Dilatation                     |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +                                             |  57        |
      Inflammation, Chronic                |                      1                                                   |      2  1.5|
      Inflammation, Chronic Active         | 1                       2                                                |     20  1.2|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +                                             |  55        |
      Atrophy                              |                                                                          |      1  3.0|
      Inflammation, Chronic Active         |                                                                          |     13  1.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Atrophy                              |       1                                                                  |      2  1.0|
      Inflammation, Chronic Active         |                                                                          |      2  1.0|
      Seminiferous Tubule, Atrophy         |                      1                                                   |      4  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  94                                                               
NTP Experiment-Test: 05061-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 09:33:30  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 4| 4| 2| 1| 7| 7| 4| 7| 6|                                            |            |
                             DAY ON TEST   | 8| 5| 5| 4| 0| 2| 2| 5| 2| 1|                                            |            |
                                           | 9| 8| 8| 9| 9| 9| 9| 8| 2| 8|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    2.0%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
    71HM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Seminiferous Tubule, Mineralization  |                                                                          |      3  1.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Myeloid Cell, Sternal, Hyperplasia   |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                +  +     +                                                |  11        |
      Hyperplasia, Lymphoid                |                3                                                         |      1  3.0|
      Lumbar, Hyperplasia, Plasma Cell     |                                                                          |      2  3.0|
      Mediastinal, Inflammation, Chronic   |                                                                          |            |
          Active                           |                         3                                                |      1  3.0|
      Pancreatic, Angiectasis              |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  +  +  M  M  +  M  +  +  +                                             |  36        |
      Depletion Lymphoid                   |                                                                          |      1  4.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
      Infiltration Cellular, Histiocyte    |                1                                                         |      8  1.0|
      Inflammation, Chronic Active         |                         2                                                |      1  2.0|
      Necrosis, Coagulative                |                                                                          |      1  1.0|
      Pigmentation                         |                1                                                         |      9  1.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  M  +  +  M  +  M  +  +  +                                             |  55        |
      Angiectasis                          | 4              1           2                                             |     21  2.0|
      Depletion Lymphoid                   |                                                                          |      1  3.0|
      Hemorrhage                           |       1              1                                                   |      4  2.0|
      Hyperplasia, Lymphoid                |                         2                                                |      4  2.5|
      Hyperplasia                          |                                                                          |      1  2.0|
      Infiltration Cellular, Histiocyte    |       1                                                                  |     22  1.0|
      Inflammation, Chronic Active         |                         2                                                |      4  2.0|
      Pigmentation                         |       1                                                                  |     20  1.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  M  +  +  +  +  +  +  +  +                                             |  58        |
      Congestion                           |                                                                          |      1  2.0|
      Depletion Lymphoid                   |                                                                          |      3  2.3|
      Fibrosis                             |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     |          2              3                                                |     12  2.6|
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
      Inflammation, Chronic Active         |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  +  +  +  +  +  +  +  M  +                                             |  41        |
      Cyst                                 |    1  1        1                                                         |     12  1.0|
      Depletion Lymphoid                   |                                                                          |      6  3.3|
      Necrosis, Coagulative                |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  95                                                               
NTP Experiment-Test: 05061-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 09:33:30  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 4| 4| 2| 1| 7| 7| 4| 7| 6|                                            |            |
                             DAY ON TEST   | 8| 5| 5| 4| 0| 2| 2| 5| 2| 1|                                            |            |
                                           | 9| 8| 8| 9| 9| 9| 9| 8| 2| 8|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    2.0%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
    71HM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  +  +  M  M  M  M  +  M  M                                             |  10        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Inflammation, Chronic Active         |          4           2                                                   |     13  1.4|
      Subcutaneous Tissue, Abscess         |                                                                          |      1  2.0|
      Subcutaneous Tissue, Fibrosis        |                                                                          |      1  2.0|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Chronic Active                  |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Joint, Tarsal, Hyperostosis          | 4                          2                                             |     12  3.4|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                         +                                                |   3        |
      Intercostal, Inflammation, Chronic   |                                                                          |            |
          Active                           |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cyst Epithelial Inclusion            |                                                                          |      1  2.0|
      Thalamus, Mineralization             |                1  1     1                                                |     19  1.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Congestion                           |                                                                          |      1  1.0|
      Hemorrhage                           |             1  2                                                         |     10  1.2|
      Infiltration Cellular, Histiocyte    |                1        2                                                |      6  1.3|
      Inflammation, Chronic Active         |                         2                                                |      1  2.0|
      Pigmentation                         |                                                                          |      1  1.0|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      4  1.3|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Inflammation, Acute                  |                                                                          |      6  1.3|
      Glands, Inflammation, Acute          |                                                                          |      2  1.0|
      Respiratory Epithelium, Necrosis     |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Inflammation, Acute                  |                                                                          |      3  1.3|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  96                                                               
NTP Experiment-Test: 05061-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 09:33:30  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 4| 4| 2| 1| 7| 7| 4| 7| 6|                                            |            |
                             DAY ON TEST   | 8| 5| 5| 4| 0| 2| 2| 5| 2| 1|                                            |            |
                                           | 9| 8| 8| 9| 9| 9| 9| 8| 2| 8|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    2.0%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
    71HM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lacrimal Gland                          |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cyst                                 |                                                                          |      1  2.0|
      Inflammation, Acute, Necrotizing     |                                                                          |      1  3.0|
      Inflammation, Chronic                |    1  2              1                                                   |      8  1.1|
      Inflammation, Chronic Active         | 1        1     1  1     2  1                                             |     47  1.2|
      Metaplasia, Osseous                  |                                                                          |      1  1.0|
      Mineralization                       |                                                                          |      1  1.0|
      Proximal Convoluted Renal Tubule,    |                                                                          |            |
           Regeneration                    |                                                                          |      1  1.0|
      Renal Tubule, Mineralization         |                                                                          |      1  1.0|
      Renal Tubule, Pigmentation           | 2              1  2     1                                                |     43  1.3|
      Renal Tubule, Regeneration           |       1                                                                  |      4  1.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Inflammation, Chronic                |                                                                          |      5  1.0|
      Inflammation, Chronic Active         |                1  1     1                                                |     34  1.1|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  97                                                               
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NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.