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TR 383 Mouse Pathology Tables

NTP                                         STATISTICAL ANALYSIS OF SURVIVAL DATA                              REPORT: PEIRPT11     
LAB: Mason                                          1-AMINO-2,4-DIBROMOANTHRAQUINONE                           DATE: 05/19/95       
EXPERIMENT: 05061 TEST: 02                                                                                     TIME: 17:22:49       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: N01ES9561903                              ROUTE: DOSED FEED                                              NTP C#: 55458        
PATHOLOGIST: R. FLEISCHMAN                                                                                     CAS: 81-49-2         
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               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  

NTP                                         STATISTICAL ANALYSIS OF SURVIVAL DATA                              REPORT: PEIRPT11    
LAB: Mason                                          1-AMINO-2,4-DIBROMOANTHRAQUINONE                           DATE: 05/19/95      
EXPERIMENT: 05061 TEST: 02                                                                                     TIME: 17:22:49      
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                       
CONT: N01ES9561903                              ROUTE: DOSED FEED                                              NTP C#: 55458       
PATHOLOGIST: R. FLEISCHMAN                                                                                     CAS: 81-49-2        

                         1-AMINO-2,4-DIBROMOANTHRAQUINONE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 729 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                          DOSE = UNTREATED 71UM                                 |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 10     CENSORED DEATHS 10   TERMINAL 40        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      292   393   445   480   521   621   705   705   723   723                 |
 |  CENSORED DEATHS                                                               |
 |      458   460   460   460   460   460   460   460   460   460                 |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 1.0%    71                               |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 28     CENSORED DEATHS 10   TERMINAL 22        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      152   414   451   464   501   505   550   572   578   582                 |
 |      583   611   612   613   618   633   633   642   647   648                 |
 |      654   673   673   689   706   709   715   717                             |
 |  CENSORED DEATHS                                                               |
 |      457   458   458   458   458   458   458   460   460   460                 |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 2.0%    71                               |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 27     CENSORED DEATHS 10   TERMINAL 23        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      109   136   248   249   484   512   517   523   535   593                 |
 |      606   613   618   618   621   633   645   648   662   665                 |
 |      689   689   696   709   722   724   726                                   |
 |  CENSORED DEATHS                                                               |
 |      458   458   458   458   458   458   458   460   460   460                 |
 |                                                                                |
 ==================================================================================

                         1-AMINO-2,4-DIBROMOANTHRAQUINONE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 729 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   729 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |UNTREATED  |   100.0 100.0 100.0  98.3  96.7  93.0  91.0  91.0  88.9  80.9      |
 |71UM       |                                                                    |
 |           |                                                                    |
 |1.0%    71 |   100.0  98.3  98.3  98.3  96.7  93.0  88.9  78.8  58.6  44.5      |
 |           |                                                                    |
 |           |                                                                    |
 |2.0%    71 |   100.0  96.7  93.3  93.3  93.3  91.3  83.2  81.2  60.9  46.7      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                    DOSE                        |
 |                                                                                |
 |                                UNTREATED        1.0%    71       2.0%    71    |
 |                                71UM                                            |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       80.9%            44.5%            46.7%         |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=0.001          P<0.001          P<0.001       |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       560.8            590.9            562.6         |
 |NATURAL DEATHS (C)      |       (49.4)           (22.3)           (33.8)        |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       656.1            619.5            609.1         |
 |(STANDARD ERROR)        |       (16.0)           (16.2)           (20.0)        |
 |                        |                                                       |
 ==================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                         1-AMINO-2,4-DIBROMOANTHRAQUINONE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 729 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                          DOSE = UNTREATED 71UF                                 |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 11     CENSORED DEATHS 10   TERMINAL 39        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      76    478   592   610   628   653   685   701   701   706                 |
 |      708                                                                       |
 |  CENSORED DEATHS                                                               |
 |      455   455   455   455   455   455   455   457   457   457                 |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 1.0%    71                               |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 16     CENSORED DEATHS 10   TERMINAL 34        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      202   372   442   503   555   587   652   657   671   679                 |
 |      706   713   713   713   716   727                                         |
 |  CENSORED DEATHS                                                               |
 |      455   455   455   455   455   457   457   457   457   457                 |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 2.0%    71                               |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 17     CENSORED DEATHS 10   TERMINAL 33        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      501   538   553   562   568   596   623   623   631   662                 |
 |      664   680   697   713   718   723   724                                   |
 |  CENSORED DEATHS                                                               |
 |      455   455   455   457   457   457   457   457   457   457                 |
 |                                                                                |
 ==================================================================================

                         1-AMINO-2,4-DIBROMOANTHRAQUINONE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 729 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   729 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |UNTREATED  |    98.3  98.3  98.3  98.3  98.3  96.3  96.3  94.3  88.3  78.3      |
 |71UF       |                                                                    |
 |           |                                                                    |
 |1.0%    71 |   100.0 100.0  98.3  98.3  96.7  95.0  93.0  88.9  84.9  68.7      |
 |           |                                                                    |
 |           |                                                                    |
 |2.0%    71 |   100.0 100.0 100.0 100.0 100.0 100.0  96.0  88.0  78.0  66.0      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                    DOSE                        |
 |                                                                                |
 |                                UNTREATED        1.0%    71       2.0%    71    |
 |                                71UF                                            |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       78.3%            68.7%            66.0%         |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=0.234          P=0.381          P=0.259       |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       594.4            600.5            633.9         |
 |NATURAL DEATHS (C)      |       (55.9)           (37.8)           (17.3)        |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       658.8            649.2            656.6         |
 |(STANDARD ERROR)        |       (16.8)           (16.6)           (13.7)        |
 |                        |                                                       |
 ==================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        UNTREATED 71UM   = 1
                                                        1.0%    71       = 2
                                                        2.0%    71       = 3

------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  100 + 1                 3     2                     1
      |                   3   3 2               3     1                1  2   1 2
      |                                                                       1 2 2 1
      |                                         3                                 2 13 2 3 1
P  90 +                                                                                22  1   2          1            1
E     |                                                                                  3 3   2  2
R     |                                                                                    3 3    22                   1  1
C     |                                                                                      3     22 3
E  80 +                                                                                             2 3 32                1 1
N     |                                                                                                  33
T     |
      |                                                                                                  22
S  70 +                                                                                                   2 2 3
U     |                                                                                                     22
R     |                                                                                                      22  3
V     |
I  60 +                                                                                                       22 3   3
V     |                                                                                                        2   2 33
A     |                                                                                                            2 23 3
L     |                                                                                                              2 23 3
   50 +                                                                                                                22
      |                                                                                                                 223 3
      |                                                                                                                  2  2
      |
   40 +
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 14 obs hidden.

                                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        UNTREATED 71UF   = 1
                                                        1.0%    71       = 2
                                                        2.0%    71       = 3

----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  100 + 1           1                   2                                              3
      |             1                   2                          2                1
      |                                                                                3     3
      |                                                            2          2     1        3 3      1
   95 +                                                                       2        2
      |                                                                                        3 3    1  1
P     |                                                                                2        233      1 1
E     |                                                                                         2   2
R  90 +                                                                                           3    3   1   1
C     |                                                                                             2          1    1
E     |                                                                                                3  3
N     |                                                                                                             1  1
T  85 +                                                                                                        2  2
      |                                                                                                   3 3
S     |                                                                                                     3    322
U     |                                                                                                            2   2
R  80 +                                                                                                                11
V     |                                                                                                                21   1
I     |                                                                                                          3  3
V     |                                                                                                             3 3
A  75 +
L     |                                                                                                               3 3
      |                                                                                                                 22
      |                                                                                                                  22
   70 +                                                                                                                  33
      |                                                                                                                   2 2
      |
      |                                                                                                                   3 3
   65 +
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 6 obs hidden.

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