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TR 383 Rat Pathology Tables


                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                  1-AMINO 2,4-DIBROMOANTHRAQUINONE


NTP Experiment-Test: 05061-01                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 05/19/95
Route: DOSED FEED                                                                                                 Time: 14:37:39




       Facility:  TSI Mason Research

       Chemical CAS #:  81-49-2

       Lock Date:  03/25/92

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05061-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                  1-AMINO 2,4-DIBROMOANTHRAQUINONE                             Date: 05/19/95  
Route: DOSED FEED                                                                                                 Time: 14:37:39  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   UNTREATE     0.2%         0.5%         1.0%         2.0%         2.0%            
                                                   D 71UF       71LF         71MLF        71MHF        71HF         FEMALE          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          70           50           70           70           30           10           
  Scheduled Sacrifice                                 20           10           10           20           21            9           
  Early Deaths                                                                                                                      
    Moribund                                           8            5           15           29            5            1           
    Dead                                               4            3            7            8            3                        
  Survivors                                                                                                                         
    Terminal Sacrifice                                37           32           38           12                                     
    Dead                                               1                                                                            
  Wrong Sex                                                                                   1            1                        
  Animals Examined Microscopically                    70           50           70           69           28           10           
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (70)         (50)         (67)         (58)         (28)         (10)         
   Intestine Large, Colon                             (69)         (50)         (69)         (57)         (28)         (10)         
      Adenocarcinoma                                                             2 (3%)       1 (2%)                                
      Adenocarcinoma, Multiple                                      1 (2%)                                                          
      Polyp Adenomatous                                                          1 (1%)       1 (2%)                                
      Polyp Adenomatous, Multiple                                   1 (2%)       1 (1%)       1 (2%)                                
   Intestine Large, Rectum                            (69)         (50)         (70)         (67)         (27)         (10)         
      Adenocarcinoma                                                1 (2%)      18 (26%)      6 (9%)                                
      Adenocarcinoma, Multiple                                                   1 (1%)       1 (1%)                                
      Polyp Adenomatous                                            10 (20%)      8 (11%)     14 (21%)      2 (7%)       5 (50%)     
      Polyp Adenomatous, Multiple                                  17 (34%)     45 (64%)     31 (46%)      1 (4%)                   
   Intestine Large, Cecum                             (70)         (50)         (70)         (57)         (28)         (10)         
      Polyp Adenomatous                                                          1 (1%)                                             
   Intestine Small, Jejunum                           (68)         (50)         (69)         (56)         (27)         (10)         
   Intestine Small, Ileum                             (69)         (49)         (69)         (54)         (28)         (10)         
      Leiomyoma                                                                  1 (1%)                                             
   Liver                                              (70)         (50)         (70)         (68)         (28)         (10)         
      Cholangioma                                                                             1 (1%)                                
      Hepatocellular Carcinoma                                      5 (10%)      6 (9%)       7 (10%)      8 (29%)      3 (30%)     
      Hepatocellular Carcinoma, Multiple                            7 (14%)     51 (73%)     44 (65%)      8 (29%)      3 (30%)     
      Hepatocellular Adenoma                                       10 (20%)      8 (11%)     10 (15%)      5 (18%)      5 (50%)     
      Hepatocellular Adenoma, Multiple                             18 (36%)     39 (56%)     27 (40%)      7 (25%)      1 (10%)     
      Hepatocholangiocarcinoma                                                  10 (14%)      8 (12%)                               
      Hepatocholangiocarcinoma, Multiple                                         1 (1%)       5 (7%)                                
      Hepatocholangioma                                                          1 (1%)                                             
      Hepatocholangioma, Multiple                                                1 (1%)                                             
   Mesentery                                          (4)          (6)          (1)          (5)          (1)                       
      Hepatocellular Carcinoma, Metastatic, Liver                                             3 (60%)                               
   Pancreas                                           (70)         (50)         (70)         (58)         (28)         (10)         
                                                             Page   2                                                               
NTP Experiment-Test: 05061-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                  1-AMINO 2,4-DIBROMOANTHRAQUINONE                             Date: 05/19/95  
Route: DOSED FEED                                                                                                 Time: 14:37:39  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   UNTREATE     0.2%         0.5%         1.0%         2.0%         2.0%            
                                                   D 71UF       71LF         71MLF        71MHF        71HF         FEMALE          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - cont                                                                                                            
      Adenoma                                                                    2 (3%)                                             
      Hepatocellular Carcinoma, Metastatic, Liver                                             1 (2%)                                
   Pharynx                                                         (1)                       (1)                                    
      Palate, Squamous Cell Papilloma, Multiple                     1 (100%)                                                        
   Stomach, Forestomach                               (69)         (50)         (70)         (67)         (28)         (10)         
      Squamous Cell Carcinoma                                       1 (2%)       1 (1%)       1 (1%)                                
      Squamous Cell Papilloma                                                                 1 (1%)                                
   Stomach, Glandular                                 (70)         (50)         (70)         (68)         (28)         (10)         
      Hepatocellular Carcinoma, Metastatic, Liver                                             1 (1%)                                
   Tongue                                                                                    (1)                                    
      Squamous Cell Papilloma                                                                 1 (100%)                              
   Tooth                                              (1)          (1)                       (1)                                    
      Gingiva, Squamous Cell Carcinoma                                                        1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (70)         (50)         (70)         (59)         (28)         (10)         
      Hepatocellular Carcinoma, Metastatic, Liver                                1 (1%)       2 (3%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (67)         (50)         (69)         (58)         (27)         (10)         
      Adenoma                                          2 (3%)       1 (2%)                                                          
      Carcinoma, Metastatic, Kidney                                                           1 (2%)                                
   Adrenal Medulla                                    (67)         (50)         (69)         (58)         (27)         (10)         
      Pheochromocytoma Complex                                                   1 (1%)                                             
      Pheochromocytoma Benign                          2 (3%)       3 (6%)       1 (1%)       2 (3%)                                
      Bilateral, Pheochromocytoma Benign                                                      1 (2%)                                
   Islets, Pancreatic                                 (50)         (40)         (60)         (47)         (7)          (1)          
      Adenoma                                                       1 (3%)                                                          
      Hepatocellular Carcinoma, Metastatic, Liver                                             1 (2%)                                
   Parathyroid Gland                                  (63)         (47)         (67)         (48)         (25)         (10)         
      Adenoma                                          1 (2%)                                                                       
   Pituitary Gland                                    (70)         (49)         (70)         (57)         (28)         (10)         
      Pars Distalis, Adenoma                          29 (41%)     16 (33%)     25 (36%)     13 (23%)      2 (7%)       2 (20%)     
      Pars Distalis, Adenoma, Multiple                 5 (7%)       3 (6%)       7 (10%)                                            
      Pars Intermedia, Adenoma                                      1 (2%)                                                          
   Thyroid Gland                                      (70)         (50)         (70)         (59)         (28)         (10)         
      Adenoma                                                                                                           1 (10%)     
      C-Cell, Adenoma                                  5 (7%)       5 (10%)      5 (7%)                                             
      C-Cell, Adenoma, Multiple                                                               1 (2%)                                
      C-Cell, Carcinoma                                1 (1%)                    1 (1%)                                             
      Follicular Cell, Adenoma                                      1 (2%)       1 (1%)       2 (3%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   3                                                               
NTP Experiment-Test: 05061-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                  1-AMINO 2,4-DIBROMOANTHRAQUINONE                             Date: 05/19/95  
Route: DOSED FEED                                                                                                 Time: 14:37:39  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   UNTREATE     0.2%         0.5%         1.0%         2.0%         2.0%            
                                                   D 71UF       71LF         71MLF        71MHF        71HF         FEMALE          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                         (2)          (1)          (1)          (1)                                    
      Basosquamous Tumor Malignant                                  1 (100%)                                                        
      Neoplasm NOS                                                               1 (100%)                                           
      Sarcoma                                          2 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (65)         (46)         (68)         (58)         (27)         (10)         
      Adenoma                                          5 (8%)       3 (7%)       3 (4%)       2 (3%)                                
   Ovary                                              (70)         (50)         (70)         (61)         (28)         (10)         
      Granulosa Cell Tumor Benign                      1 (1%)       1 (2%)                                                          
      Hepatocellular Carcinoma, Metastatic, Liver                                1 (1%)       1 (2%)                                
   Uterus                                             (70)         (50)         (70)         (60)         (28)         (10)         
      Adenocarcinoma                                   1 (1%)                                                                       
      Hemangioma                                       1 (1%)                                                                       
      Polyp Stromal                                    8 (11%)     12 (24%)      8 (11%)      6 (10%)      1 (4%)       1 (10%)     
      Polyp Stromal, Multiple                          1 (1%)       3 (6%)                                                          
      Sarcoma Stromal                                                            1 (1%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (70)         (50)         (70)         (59)         (28)         (10)         
   Lymph Node                                         (7)          (11)         (28)         (24)         (9)          (1)          
      Mediastinal, Hepatocellular Carcinoma,                                                                                        
          Metastatic, Liver                                                                   1 (4%)                                
   Lymph Node, Mandibular                             (66)         (49)         (66)         (53)         (27)         (9)          
   Lymph Node, Mesenteric                             (70)         (50)         (69)         (60)         (28)         (9)          
   Spleen                                             (70)         (50)         (70)         (58)         (28)         (10)         
      Hepatocellular Carcinoma, Metastatic, Liver                                1 (1%)                                             
      Lipoma                                                        1 (2%)                                                          
   Thymus                                             (62)         (41)         (61)         (55)         (22)         (10)         
      Hepatocellular Carcinoma, Metastatic, Liver                                             1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (65)         (38)         (54)         (47)         (19)         (7)          
      Adenocarcinoma                                   2 (3%)                                                                       
      Fibroadenoma                                    18 (28%)      8 (21%)      9 (17%)      5 (11%)                               
      Fibroadenoma, Multiple                           4 (6%)       2 (5%)                                                          
      Fibroma                                          1 (2%)                                                                       
   Skin                                               (70)         (49)         (70)         (60)         (28)         (10)         
      Squamous Cell Papilloma                          1 (1%)                    1 (1%)       1 (2%)                                
      Pinna, Granular Cell Tumor Benign                                          1 (1%)                                             
                                                             Page   4                                                               
NTP Experiment-Test: 05061-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                  1-AMINO 2,4-DIBROMOANTHRAQUINONE                             Date: 05/19/95  
Route: DOSED FEED                                                                                                 Time: 14:37:39  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   UNTREATE     0.2%         0.5%         1.0%         2.0%         2.0%            
                                                   D 71UF       71LF         71MLF        71MHF        71HF         FEMALE          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - cont                                                                                                         
      Pinna, Squamous Cell Papilloma                                             2 (3%)       2 (3%)                                
      Subcutaneous Tissue, Fibroma                     2 (3%)       2 (4%)                    1 (2%)                                
      Subcutaneous Tissue, Sarcoma                     1 (1%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (70)         (50)         (70)         (59)         (28)         (10)         
      Basosquamous Tumor Malignant, Metastatic,                                                                                     
           Tissue NOS                                               1 (2%)                                                          
      Squamous Cell Carcinoma, Metastatic,                                                                                          
          Uncertain Primary Site                                                              1 (2%)                                
   Skeletal Muscle                                                 (1)                                                              
      Rhabdomyosarcoma                                              1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (70)         (50)         (70)         (59)         (28)         (10)         
      Oligodendroglioma Benign                                                                1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (70)         (50)         (70)         (64)         (28)         (10)         
      Alveolar/Bronchiolar Adenoma                     1 (1%)       2 (4%)       1 (1%)                                             
      Alveolar/Bronchiolar Adenoma, Multiple                        1 (2%)                                                          
      Alveolar/Bronchiolar Carcinoma                                                          1 (2%)                                
      Hepatocellular Carcinoma, Metastatic, Liver                   1 (2%)      22 (31%)     24 (38%)      1 (4%)       1 (10%)     
      Neoplasm NOS, Metastatic, Uncertain Primary                                                                                   
          Site                                                                                1 (2%)                                
      Sarcoma, Metastatic, Thymus                      1 (1%)                                                                       
      Squamous Cell Carcinoma                                       1 (2%)                                                          
   Nose                                               (70)         (50)         (70)         (59)         (28)         (10)         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                                          (8)          (3)                                    
   Zymbal's Gland                                     (1)                       (2)                                                 
      Adenoma                                                                    1 (50%)                                            
      Carcinoma                                                                  1 (50%)                                            
      Squamous Cell Carcinoma                          1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   5                                                               
NTP Experiment-Test: 05061-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                  1-AMINO 2,4-DIBROMOANTHRAQUINONE                             Date: 05/19/95  
Route: DOSED FEED                                                                                                 Time: 14:37:39  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   UNTREATE     0.2%         0.5%         1.0%         2.0%         2.0%            
                                                   D 71UF       71LF         71MLF        71MHF        71HF         FEMALE          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (70)         (50)         (70)         (68)         (28)         (10)         
      Adenoma                                                                                              1 (4%)                   
      Squamous Cell Carcinoma, Metastatic, Urinary                                                                                  
          Bladder                                                                1 (1%)                                             
      Pelvis, Transitional Epithelium, Carcinoma                    1 (2%)                                                          
      Pelvis, Transitional Epithelium, Papilloma                                              1 (1%)                                
      Renal Tubule, Adenoma                                         3 (6%)      11 (16%)     11 (16%)      1 (4%)       3 (30%)     
      Renal Tubule, Adenoma, Multiple                                            5 (7%)       5 (7%)       1 (4%)                   
      Renal Tubule, Carcinoma                                                                 2 (3%)                                
   Urinary Bladder                                    (70)         (50)         (70)         (66)         (28)         (10)         
      Carcinoma                                                                               2 (3%)       4 (14%)      1 (10%)     
      Papilloma                                                                               1 (2%)       1 (4%)                   
      Squamous Cell Carcinoma                                                                 2 (3%)                                
      Transitional Epithelium, Carcinoma                                         8 (11%)     16 (24%)      1 (4%)                   
      Transitional Epithelium, Papilloma                            2 (4%)       6 (9%)       9 (14%)      1 (4%)                   
      Transitional Epithelium, Papilloma, Multiple                               1 (1%)                                             
      Transitional Epithelium, Squamous Cell                                                                                        
          Carcinoma                                                              1 (1%)                                             
      Transitional Epithelium, Squamous Cell                                                                                        
          Papilloma                                                              1 (1%)       1 (2%)                                
      Transitional Epithelium, Squamous Cell                                                                                        
          Papilloma, Multiple                                                                 1 (2%)                                
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(70)        *(50)        *(70)        *(69)        *(28)        *(10)         
      Leukemia Mononuclear                             9 (13%)      1 (2%)       5 (7%)       1 (1%)                                
      Lymphoma Malignant Histiocytic                                                          1 (1%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   6                                                               
NTP Experiment-Test: 05061-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                  1-AMINO 2,4-DIBROMOANTHRAQUINONE                             Date: 05/19/95  
Route: DOSED FEED                                                                                                 Time: 14:37:39  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   UNTREATE     0.2%         0.5%         1.0%         2.0%         2.0%            
                                                   D 71UF       71LF         71MLF        71MHF        71HF         FEMALE          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            48          40          61          57          21           9               
     Total Primary Neoplasms                          104         148         307         252          44          25               
                                                                                                                                    
   Total Animals with Benign Neoplasms                 45          40          61          54          16           9               
     Total Benign Neoplasms                            87         128         198         153          23          18               
                                                                                                                                    
   Total Animals with Malignant Neoplasms              16          15          60          55          17           6               
     Total Malignant Neoplasms                         17          20         108          99          21           7               
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              1           2          22          27           1           1               
     Total Metastatic Neoplasm                          1           2          26          38           1           1               
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                   2                                       
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                          1                                                   
     Total Uncertain Neoplasms                                                  1                                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   7                                                               
NTP Experiment-Test: 05061-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                  1-AMINO 2,4-DIBROMOANTHRAQUINONE                             Date: 05/19/95  
Route: DOSED FEED                                                                                                 Time: 14:37:39  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     UNTREATE     0.2%         0.5%         1.0%         2.0%         2.0%            
                                                   D 71 UM       71LM        71MLM        71MHM        71HM         MALE            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          70           50           70           70           30           10           
  Scheduled Sacrifice                                 20           10           10           20           27            7           
  Early Deaths                                                                                                                      
    Moribund                                          19           15           34           33            2            3           
    Dead                                               5            1            5            7            1                        
  Survivors                                                                                                                         
    Terminal Sacrifice                                23           24           21           10                                     
    Moribund                                           2                                                                            
    Dead                                               1                                                                            
  Animals Examined Microscopically                    70           50           69           70           30           10           
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (67)         (50)         (69)         (61)         (30)         (10)         
      Adenocarcinoma                                                             1 (1%)       4 (7%)                                
      Polyp Adenomatous                                             1 (2%)                                 1 (3%)                   
      Polyp Adenomatous, Multiple                                                1 (1%)       3 (5%)                                
   Intestine Large, Rectum                            (65)         (50)         (68)         (69)         (30)         (10)         
      Adenocarcinoma                                                1 (2%)      10 (15%)     12 (17%)      2 (7%)                   
      Adenocarcinoma, Multiple                                                                3 (4%)                                
      Polyp Adenomatous                                            12 (24%)     17 (25%)     16 (23%)      6 (20%)      2 (20%)     
      Polyp Adenomatous, Multiple                                   1 (2%)      34 (50%)     30 (43%)      1 (3%)       1 (10%)     
   Intestine Large, Cecum                             (68)         (50)         (69)         (60)         (28)         (10)         
   Intestine Small, Duodenum                          (68)         (50)         (69)         (60)         (29)         (9)          
   Intestine Small, Jejunum                           (68)         (48)         (67)         (58)         (29)         (10)         
   Intestine Small, Ileum                             (68)         (50)         (67)         (59)         (29)         (10)         
   Liver                                              (70)         (50)         (69)         (70)         (30)         (10)         
      Cholangiocarcinoma                                                                      1 (1%)                                
      Cholangioma                                                                2 (3%)                                             
      Hepatocellular Carcinoma                         1 (1%)      11 (22%)     12 (17%)     13 (19%)      8 (27%)      4 (40%)     
      Hepatocellular Carcinoma, Multiple                            1 (2%)      43 (62%)     40 (57%)     13 (43%)      3 (30%)     
      Hepatocellular Adenoma                           1 (1%)      10 (20%)     18 (26%)     12 (17%)      5 (17%)      7 (70%)     
      Hepatocellular Adenoma, Multiple                             10 (20%)     23 (33%)     26 (37%)      5 (17%)                  
      Hepatocholangiocarcinoma                                                   5 (7%)       2 (3%)                    1 (10%)     
      Hepatocholangiocarcinoma, Multiple                                         1 (1%)                                             
      Hepatocholangioma                                                          1 (1%)       1 (1%)                                
      Myxoma                                                                     1 (1%)                                             
   Mesentery                                          (3)          (3)          (4)          (5)          (1)          (1)          
   Pancreas                                           (70)         (50)         (69)         (60)         (30)         (10)         
      Adenocarcinoma, Metastatic, Intestine Large,                                                                                  
           Rectum                                                                             1 (2%)                                
      Adenoma                                          3 (4%)                                                                       
                                                             Page   8                                                               
NTP Experiment-Test: 05061-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                  1-AMINO 2,4-DIBROMOANTHRAQUINONE                             Date: 05/19/95  
Route: DOSED FEED                                                                                                 Time: 14:37:39  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     UNTREATE     0.2%         0.5%         1.0%         2.0%         2.0%            
                                                   D 71 UM       71LM        71MLM        71MHM        71HM         MALE            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - cont                                                                                                            
   Salivary Glands                                    (70)         (50)         (68)         (59)         (29)         (10)         
   Stomach, Forestomach                               (69)         (49)         (69)         (69)         (30)         (10)         
      Squamous Cell Carcinoma                                                                 1 (1%)                                
      Squamous Cell Papilloma                                       2 (4%)                    1 (1%)       1 (3%)                   
   Stomach, Glandular                                 (70)         (50)         (69)         (70)         (30)         (10)         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (70)         (50)         (69)         (59)         (30)         (10)         
      Hepatocholangiocarcinoma, Metastatic, Liver                                                                       1 (10%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (70)         (50)         (68)         (60)         (30)         (10)         
      Hepatocellular Carcinoma, Metastatic, Liver                                             1 (2%)                                
   Adrenal Medulla                                    (69)         (50)         (68)         (60)         (30)         (10)         
      Ganglioneuroma                                                             1 (1%)                                             
      Pheochromocytoma Malignant                       1 (1%)       2 (4%)       1 (1%)                                             
      Pheochromocytoma Benign                         11 (16%)     12 (24%)     11 (16%)      5 (8%)                                
      Bilateral, Pheochromocytoma Benign               1 (1%)       3 (6%)       2 (3%)       2 (3%)                                
   Islets, Pancreatic                                 (54)         (40)         (58)         (50)         (3)          (3)          
      Adenoma                                          2 (4%)       2 (5%)                    1 (2%)                                
   Parathyroid Gland                                  (63)         (45)         (65)         (54)         (30)         (10)         
      Adenoma                                                                    1 (2%)                                             
   Pituitary Gland                                    (65)         (50)         (65)         (58)         (29)         (10)         
      Pars Distalis, Adenoma                          21 (32%)     12 (24%)      9 (14%)     10 (17%)      1 (3%)                   
      Pars Distalis, Adenoma, Multiple                 1 (2%)       2 (4%)       1 (2%)                                             
      Pars Distalis, Carcinoma                                      1 (2%)                                                          
      Pars Intermedia, Adenoma                                      1 (2%)                                                          
   Thyroid Gland                                      (69)         (50)         (69)         (61)         (30)         (10)         
      Adenoma                                          1 (1%)                                 1 (2%)                                
      C-Cell, Adenoma                                 10 (14%)      5 (10%)      3 (4%)       3 (5%)                                
      Follicular Cell, Adenoma                                                   2 (3%)       1 (2%)       1 (3%)                   
      Follicular Cell, Carcinoma                       2 (3%)       3 (6%)       1 (1%)       3 (5%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   9                                                               
NTP Experiment-Test: 05061-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                  1-AMINO 2,4-DIBROMOANTHRAQUINONE                             Date: 05/19/95  
Route: DOSED FEED                                                                                                 Time: 14:37:39  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     UNTREATE     0.2%         0.5%         1.0%         2.0%         2.0%            
                                                   D 71 UM       71LM        71MLM        71MHM        71HM         MALE            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Coagulating Gland                                  (2)          (2)                                                              
   Epididymis                                         (70)         (50)         (69)         (60)         (30)         (10)         
   Preputial Gland                                    (67)         (48)         (66)         (56)         (29)         (10)         
      Adenocarcinoma                                   1 (1%)                    1 (2%)                                             
      Adenoma                                          3 (4%)       2 (4%)       1 (2%)       1 (2%)                                
      Carcinoma                                                                                            1 (3%)                   
   Prostate                                           (70)         (50)         (68)         (59)         (30)         (10)         
   Seminal Vesicle                                    (69)         (50)         (69)         (60)         (30)         (10)         
   Testes                                             (70)         (50)         (69)         (68)         (30)         (10)         
      Adenoma                                          1 (1%)                                                                       
      Bilateral, Interstitial Cell, Adenoma           40 (57%)     34 (68%)     49 (71%)     38 (56%)                   1 (10%)     
      Interstitial Cell, Adenoma                       5 (7%)       3 (6%)       6 (9%)      10 (15%)      3 (10%)      3 (30%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (70)         (50)         (69)         (60)         (30)         (10)         
   Lymph Node                                         (19)         (6)          (18)         (25)         (6)          (2)          
      Lumbar, Adenocarcinoma, Metastatic,                                                                                           
          Intestine Large, Rectum                                                1 (6%)                                             
      Mediastinal, Hepatocellular Carcinoma,                                                                                        
          Metastatic, Liver                                                                                1 (17%)                  
   Lymph Node, Mandibular                             (70)         (50)         (64)         (59)         (27)         (8)          
   Lymph Node, Mesenteric                             (68)         (50)         (67)         (60)         (30)         (9)          
      Adenocarcinoma, Metastatic, Intestine Large,                                                                                  
           Colon                                                                 1 (1%)                                             
   Spleen                                             (70)         (50)         (68)         (62)         (30)         (10)         
      Fibroma                                                                    1 (1%)                                             
      Sarcoma                                                       1 (2%)                                                          
   Thymus                                             (56)         (41)         (51)         (53)         (26)         (9)          
      Thymoma Benign                                                             1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (39)         (29)         (34)         (29)         (15)         (7)          
      Adenocarcinoma                                                             1 (3%)                                             
      Fibroadenoma                                                  1 (3%)                                                          
      Fibroadenoma, Multiple                           1 (3%)                                                                       
   Skin                                               (70)         (48)         (68)         (60)         (29)         (10)         
      Basal Cell Adenoma                                                         1 (1%)       1 (2%)                                
      Basal Cell Carcinoma                             2 (3%)                                                                       
      Keratoacanthoma                                  1 (1%)       1 (2%)                    1 (2%)                                
      Squamous Cell Papilloma                          1 (1%)                    3 (4%)       1 (2%)                                
      Trichoepithelioma                                1 (1%)                                                                       
      Pinna, Squamous Cell Papilloma                                2 (4%)       2 (3%)       1 (2%)                                
                                                             Page  10                                                               
NTP Experiment-Test: 05061-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                  1-AMINO 2,4-DIBROMOANTHRAQUINONE                             Date: 05/19/95  
Route: DOSED FEED                                                                                                 Time: 14:37:39  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     UNTREATE     0.2%         0.5%         1.0%         2.0%         2.0%            
                                                   D 71 UM       71LM        71MLM        71MHM        71HM         MALE            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - cont                                                                                                         
      Subcutaneous Tissue, Fibroma                     2 (3%)                    3 (4%)       1 (2%)                                
      Subcutaneous Tissue, Fibrosarcoma                1 (1%)                    1 (1%)                                             
      Subcutaneous Tissue, Lipoma                      1 (1%)                                                                       
      Subcutaneous Tissue, Sarcoma                     1 (1%)       3 (6%)       1 (1%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                    (2)          (1)          (1)                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (70)         (50)         (69)         (60)         (30)         (10)         
      Carcinoma, Metastatic, Pituitary Gland                        1 (2%)                                                          
      Oligodendroglioma Benign                         1 (1%)                                                                       
      Cerebrum, Meningioma Benign                      1 (1%)                                                                       
      Meninges, Granular Cell Tumor Benign                                       1 (1%)                                             
   Peripheral Nerve                                                             (2)                                                 
      Squamous Cell Carcinoma, Metastatic,                                                                                          
          Uncertain Primary Site                                                 1 (50%)                                            
   Spinal Cord                                        (5)          (1)          (1)          (4)                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (70)         (50)         (69)         (62)         (30)         (10)         
      Adenocarcinoma, Metastatic, Kidney                                         1 (1%)                                             
      Adenocarcinoma, Metastatic, Intestine Large,                                                                                  
           Colon                                                                 1 (1%)                                             
      Alveolar/Bronchiolar Adenoma                     1 (1%)       2 (4%)       2 (3%)       4 (6%)       1 (3%)                   
      Alveolar/Bronchiolar Carcinoma                                1 (2%)       2 (3%)                                             
      Hepatocellular Carcinoma, Metastatic, Liver                   1 (2%)      18 (26%)     19 (31%)      7 (23%)      5 (50%)     
      Hepatocholangiocarcinoma, Metastatic, Liver                                                                       1 (10%)     
      Pheochromocytoma Malignant, Metastatic,                                                                                       
          Adrenal Medulla                              1 (1%)                                                                       
      Sarcoma, Metastatic, Kidney                                                             1 (2%)                                
      Sarcoma, Metastatic, Skin                        1 (1%)                                                                       
      Mediastinum, Alveolar/Bronchiolar Carcinoma                                             1 (2%)                                
   Nose                                               (68)         (50)         (69)         (60)         (30)         (10)         
   Trachea                                            (70)         (50)         (69)         (60)         (30)         (10)         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page  11                                                               
NTP Experiment-Test: 05061-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                  1-AMINO 2,4-DIBROMOANTHRAQUINONE                             Date: 05/19/95  
Route: DOSED FEED                                                                                                 Time: 14:37:39  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     UNTREATE     0.2%         0.5%         1.0%         2.0%         2.0%            
                                                   D 71 UM       71LM        71MLM        71MHM        71HM         MALE            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                (4)          (7)          (2)          (1)                                    
      Fibrosarcoma                                     1 (25%)                                                                      
   Eye                                                (6)          (3)          (1)          (6)          (1)                       
   Zymbal's Gland                                     (1)          (1)          (1)          (2)                                    
      Carcinoma                                        1 (100%)     1 (100%)                  1 (50%)                               
      Squamous Cell Carcinoma                                                    1 (100%)     1 (50%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (70)         (50)         (69)         (70)         (30)         (10)         
      Hepatocellular Carcinoma, Metastatic, Liver                   1 (2%)                                 1 (3%)                   
      Pelvis, Transitional Epithelium, Papilloma                                 1 (1%)                                             
      Renal Tubule, Adenoma                            2 (3%)       6 (12%)      7 (10%)     11 (16%)      2 (7%)       3 (30%)     
      Renal Tubule, Adenoma, Multiple                               4 (8%)       4 (6%)       5 (7%)                                
      Renal Tubule, Carcinoma                                                    2 (3%)       1 (1%)                                
   Urinary Bladder                                    (70)         (48)         (67)         (70)         (28)         (10)         
      Papilloma                                                                                            4 (14%)                  
      Squamous Cell Carcinoma                                                                              1 (4%)                   
      Transitional Epithelium, Carcinoma                                         1 (1%)       4 (6%)       1 (4%)                   
      Transitional Epithelium, Papilloma                            1 (2%)       2 (3%)       8 (11%)                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(70)        *(50)        *(69)        *(70)        *(30)        *(10)         
      Leukemia Mononuclear                            25 (36%)      5 (10%)      3 (4%)       3 (4%)                                
      Mesothelioma Malignant                           1 (1%)       1 (2%)       1 (1%)       2 (3%)       1 (3%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  12                                                               
NTP Experiment-Test: 05061-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                  1-AMINO 2,4-DIBROMOANTHRAQUINONE                             Date: 05/19/95  
Route: DOSED FEED                                                                                                 Time: 14:37:39  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     UNTREATE     0.2%         0.5%         1.0%         2.0%         2.0%            
                                                   D 71 UM       71LM        71MLM        71MHM        71HM         MALE            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            57          40          61          58          26          10               
     Total Primary Neoplasms                          149         160         299         286          58          25               
                                                                                                                                    
   Total Animals with Benign Neoplasms                 57          40          60          57          20          10               
     Total Benign Neoplasms                           112         129         211         194          31          17               
                                                                                                                                    
   Total Animals with Malignant Neoplasms              29          24          57          55          21           8               
     Total Malignant Neoplasms                         37          31          88          92          27           8               
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              2           3          20          22           7           6               
     Total Metastatic Neoplasm                          2           3          23          22           9           7               
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                       1                                                   
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  13                                                               
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                             ----------              END OF REPORT             ----------                                           
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