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TR 383 Rat Pathology Tables

NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Mason                                          1-AMINO 2,4-DIBROMOANTHRAQUINONE                           DATE: 05/19/95       
EXPERIMENT: 05061 TEST: 01                                                                                     TIME: 15:07:25       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: N01ES9561903                              ROUTE: DOSED FEED                                              NTP C#: 55458        
PATHOLOGIST: R. FLEISCHMAN                                                                                     CAS: 81-49-2         
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               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Mason                                          1-AMINO 2,4-DIBROMOANTHRAQUINONE                           DATE: 05/19/95       
EXPERIMENT: 05061 TEST: 01                                                                                     TIME: 15:07:25       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01ES9561903                              ROUTE: DOSED FEED                                              NTP C#: 55458        
PATHOLOGIST: R. FLEISCHMAN                                                                                     CAS: 81-49-2         


                                                    RATS(FISCHER344)
                                              ----------------------------
             FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
             IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
                                                                    
                                                    ----------------
                                                    Adrenal Cortex
                                                    Adrenal Medulla
                                                    Bone Marrow
                                                    Brain
                                                    Clitoral Gland
                                                    Clitoral/Preputial Gland
                                                    Epididymis
                                                    Heart
                                                    Islets, Pancreatic
                                                    Kidney
                                                    Liver
                                                    Lung
                                                    Nose
                                                    Ovary
                                                    Pancreas
                                                    Parathyroid Gland
                                                    Pituitary Gland
                                                    Preputial Gland
                                                    Prostate
                                                    Salivary Glands
                                                    Spleen
                                                    Testes
                                                    Thymus
                                                    Thyroid Gland
                                                    Urinary Bladder
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Mason                                          1-AMINO 2,4-DIBROMOANTHRAQUINONE                           DATE: 05/19/95       
EXPERIMENT: 05061 TEST: 01                                                                                     TIME: 15:07:25       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01ES9561903                              ROUTE: DOSED FEED                                              NTP C#: 55458        
PATHOLOGIST: R. FLEISCHMAN                                                                                     CAS: 81-49-2         


                                     SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
                                IN THE ANALYSIS OF THE STUDY OF 1-AMINO 2,4-DIBROMOANTHRAQUINONE
              ====================================================================================================
                                                           MALE RATS
                                                          -------------
                  ORGAN                               MORPHOLOGY
                 -------                             ------------
              Adrenal Medulla               Pheochromocytoma Benign
                                            Pheochromocytoma: Benign, Complex, Malignant, NOS
              Intestine Large: Colon/Rectum Carcinoma
                                            Polyp Adenomatous
              Kidney: Renal Tubule          Adenoma
                                            Carcinoma or Adenoma
              Liver                         Hepatocellular Adenoma
                                            Hepatocellular Carcinoma
                                            Hepatocellular Carcinoma or Hepatocellular Adenoma
                                            Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma
                                            Hepatocholangiocarcinoma
              Lung                          Alveolar/Bronchiolar Adenoma
                                            Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma
              Pituitary Gland: Pars Distalis or Unspecified Site
                                            Adenoma
                                            Carcinoma or Adenoma
              Skin                          Fibroma, Fibrosarcoma, Sarcoma, Myxoma, Myxosarcoma, or Fibrous Histiocytoma
              Testes                        Adenoma
              Thyroid Gland: C-Cell         Adenoma
                                            Carcinoma or Adenoma
              Thyroid Gland: Follicular Cell
                                            Adenoma
                                            Carcinoma or Adenoma
              Urinary Bladder               Carcinoma
                                            Papilloma
              All Organs                    Leukemia: Lymphocytic, Monocytic, Mononuclear, or Undifferentiated
                                            Benign Tumors
                                            Malignant Tumors
                                            Malignant and Benign Tumors
              ====================================================================================================
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Mason                                          1-AMINO 2,4-DIBROMOANTHRAQUINONE                           DATE: 05/19/95       
EXPERIMENT: 05061 TEST: 01                                                                                     TIME: 15:07:25       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01ES9561903                              ROUTE: DOSED FEED                                              NTP C#: 55458        
PATHOLOGIST: R. FLEISCHMAN                                                                                     CAS: 81-49-2         


                                     SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
                                IN THE ANALYSIS OF THE STUDY OF 1-AMINO 2,4-DIBROMOANTHRAQUINONE
              ====================================================================================================
                                                           FEMALE RATS
                                                          -------------
                  ORGAN                               MORPHOLOGY
                 -------                             ------------
              Intestine Large: Colon/Rectum Carcinoma
                                            Polyp Adenomatous
              Kidney: Renal Tubule          Adenoma
                                            Carcinoma
                                            Carcinoma or Adenoma
              Liver                         Hepatocellular Adenoma
                                            Hepatocellular Carcinoma
                                            Hepatocellular Carcinoma or Hepatocellular Adenoma
                                            Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma
                                            Hepatocholangiocarcinoma
              Mammary Gland                 Fibroadenoma
                                            Fibroma, Fibroadenoma or Adenoma
                                            Fibroma, Fibroadenoma, Carcinoma, or Adenoma
              Pituitary Gland: Pars Distalis or Unspecified Site
                                            Adenoma
                                            Carcinoma or Adenoma
              Skin                          Basal or Sq. Cell Carcinoma, Carcinoma, Basosq. Tumor (M or B), Basal
                                             Cell Adenoma, Adenoma, Papilloma, Sq Papilloma, Keratoacanthoma, Trichoepithelioma
                                            Squamous Cell Papilloma
                                            Squamous Cell Papilloma, Papilloma, Squamous Cell Carcinoma or Keratoacanthoma
                                            Squamous Cell Papilloma, Papilloma, or Keratoacanthoma
              Thyroid Gland: C-Cell         Adenoma
                                            Carcinoma or Adenoma
              Tissue NOS                    Sarcoma
              Urinary Bladder               Carcinoma
                                            Papilloma
                                            Squamous Cell Papilloma
              Uterus                        Polyp Stromal
                                            Sarcoma Stromal or Polyp Stromal
              All Organs                    Leukemia: Lymphocytic, Monocytic, Mononuclear, or Undifferentiated
                                            Benign Tumors
                                            Malignant Tumors
                                            Malignant and Benign Tumors
              ====================================================================================================
         DATE: 05/19/95                     EXPERIMENT: 05061 TEST: 01                                                 PAGE   1
                   STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE RATS(FISCHER344) -- 1-AMINO 2,4-DIBROMOANTHRAQUINONE
                       TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE                   |         UNTREATE           0.2%               0.5%               1.0%               2.0%                |
|                       |         D 71 UM            71LM               71MLM              71MHM              MALE                |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                                                                         |
|-----------            |                                                                                                         |
|OVERALL (a)            |        0/70 (0%)          0/50 (0%)          0/68 (0%)          0/60 (0%)          0/40 (0%)            |
|ADJUSTED (b)           |         0.0%               0.0%               0.0%               0.0%               0.0%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 2 (c)|        0/10 (0%)          0/0                0/0                0/0                0/24 (0%)            |
|TERMINAL (d)           |        0/26 (0%)          0/24 (0%)          0/20 (0%)          0/10 (0%)          0/0                  |
|FIRST INCIDENCE (DAYS) |         ---                ---                ---                ---                ---                 |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |          (e)                (e)                (e)                (e)                (e)                |
|INCIDENTAL TUMOR       |          (e)                (e)                (e)                (e)                (e)                |
|LOGISTIC REGRESSION    |          (e)                (e)                (e)                (e)                (e)                |
|COCHRAN-ARMITAGE       |          (e)                                                                                            |
|FISHER EXACT           |                             (e)                (e)                (e)                (e)                |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Pheochromocytoma Benign                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                                                                         |
|-----------            |                                                                                                         |
|OVERALL (a)            |       12/69 (17%)        15/50 (30%)        13/68 (19%)         7/60 (12%)         0/40 (0%)            |
|ADJUSTED (b)           |        36.6%              45.3%              38.7%              39.0%               0.0%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 2 (c)|        0/9 (0%)           0/0                0/0                0/0                0/24 (0%)            |
|TERMINAL (d)           |        7/26 (27%)         7/24 (29%)         4/20 (20%)         2/10 (20%)         0/0                  |
|FIRST INCIDENCE (DAYS) |         574                629                521                590                ---                 |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P=0.542            P=0.257            P=0.407            P=0.475              (e)                |
|INCIDENTAL TUMOR       |        P=0.107N           P=0.191            P=0.523N           P=0.347N             (e)                |
|LOGISTIC REGRESSION    |        P=0.115N           P=0.171            P=0.570            P=0.414N           P=0.505N             |
|COCHRAN-ARMITAGE       |        P<0.001N**                                                                                       |
|FISHER EXACT           |                           P=0.081            P=0.484            P=0.254N           P=0.003N**           |
|=================================================================================================================================|
         DATE: 05/19/95                     EXPERIMENT: 05061 TEST: 01                                                 PAGE   2
                   STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE RATS(FISCHER344) -- 1-AMINO 2,4-DIBROMOANTHRAQUINONE
                       TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE                   |         UNTREATE           0.2%               0.5%               1.0%               2.0%                |
|                       |         D 71 UM            71LM               71MLM              71MHM              MALE                |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Pheochromocytoma Malignant                                                                                                  |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                                                                         |
|-----------            |                                                                                                         |
|OVERALL (a)            |        1/69 (1%)          2/50 (4%)          1/68 (1%)          0/60 (0%)          0/40 (0%)            |
|ADJUSTED (b)           |         3.1%               6.9%               3.2%               0.0%               0.0%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 2 (c)|        0/9 (0%)           0/0                0/0                0/0                0/24 (0%)            |
|TERMINAL (d)           |        0/26 (0%)          1/24 (4%)          0/20 (0%)          0/10 (0%)          0/0                  |
|FIRST INCIDENCE (DAYS) |         692                653                693                ---                ---                 |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P=0.503N           P=0.470            P=0.757            P=0.615N             (e)                |
|INCIDENTAL TUMOR       |        P=0.356N           P=0.472            P=0.652N           P=0.485N             (e)                |
|LOGISTIC REGRESSION    |        P=0.353N           P=0.440            P=0.751N           P=0.570N           P=0.998N             |
|COCHRAN-ARMITAGE       |        P=0.183N                                                                                         |
|FISHER EXACT           |                           P=0.380            P=0.748            P=0.535N           P=0.633N             |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Pheochromocytoma: Benign, Complex, Malignant, NOS                                                                           |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                                                                         |
|-----------            |                                                                                                         |
|OVERALL (a)            |       13/69 (19%)        17/50 (34%)        14/68 (21%)         7/60 (12%)         0/40 (0%)            |
|ADJUSTED (b)           |        38.6%              50.0%              40.7%              39.0%               0.0%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 2 (c)|        0/9 (0%)           0/0                0/0                0/0                0/24 (0%)            |
|TERMINAL (d)           |        7/26 (27%)         8/24 (33%)         4/20 (20%)         2/10 (20%)         0/0                  |
|FIRST INCIDENCE (DAYS) |         574                629                521                590                ---                 |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P=0.548N           P=0.200            P=0.409            P=0.547              (e)                |
|INCIDENTAL TUMOR       |        P=0.059N           P=0.133            P=0.479N           P=0.252N             (e)                |
|LOGISTIC REGRESSION    |        P=0.064N           P=0.231            P=0.575            P=0.332N           P=0.465N             |
|COCHRAN-ARMITAGE       |        P<0.001N**                                                                                       |
|FISHER EXACT           |                           P=0.048 *          P=0.483            P=0.190N           P=0.002N**           |
|=================================================================================================================================|
         DATE: 05/19/95                     EXPERIMENT: 05061 TEST: 01                                                 PAGE   3
                   STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE RATS(FISCHER344) -- 1-AMINO 2,4-DIBROMOANTHRAQUINONE
                       TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE                   |         UNTREATE           0.2%               0.5%               1.0%               2.0%                |
|                       |         D 71 UM            71LM               71MLM              71MHM              MALE                |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral/Preputial Gland                                                                                                         |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                                                                         |
|-----------            |                                                                                                         |
|OVERALL (a)            |        3/67 (4%)          2/48 (4%)          1/66 (2%)          1/56 (2%)          0/39 (0%)            |
|ADJUSTED (b)           |        11.0%               7.2%               2.4%               2.5%               0.0%                |
|INTERIM SACRIFICE 1 (c)|        0/9 (0%)           0/9 (0%)           0/8 (0%)           0/9 (0%)           0/10 (0%)            |
|INTERIM SACRIFICE 2 (c)|        0/9 (0%)           0/0                0/0                0/0                0/24 (0%)            |
|TERMINAL (d)           |        2/25 (8%)          1/23 (4%)          0/21 (0%)          0/9 (0%)           0/0                  |
|FIRST INCIDENCE (DAYS) |         696                659                650                552                ---                 |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P=0.479N           P=0.543N           P=0.332N           P=0.557N             (e)                |
|INCIDENTAL TUMOR       |        P=0.322N           P=0.537N           P=0.260N           P=0.409N             (e)                |
|LOGISTIC REGRESSION    |        P=0.247N           P=0.558N           P=0.278N           P=0.434N             (e)                |
|COCHRAN-ARMITAGE       |        P=0.111N                                                                                         |
|FISHER EXACT           |                           P=0.655N           P=0.315N           P=0.380N           P=0.248N             |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral/Preputial Gland                                                                                                         |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                                                                         |
|-----------            |                                                                                                         |
|OVERALL (a)            |        3/67 (4%)          2/48 (4%)          2/66 (3%)          1/56 (2%)          1/39 (3%)            |
|ADJUSTED (b)           |        11.0%               7.2%               5.6%               2.5%               4.2%                |
|INTERIM SACRIFICE 1 (c)|        0/9 (0%)           0/9 (0%)           0/8 (0%)           0/9 (0%)           0/10 (0%)            |
|INTERIM SACRIFICE 2 (c)|        0/9 (0%)           0/0                0/0                0/0                1/24 (4%)            |
|TERMINAL (d)           |        2/25 (8%)          1/23 (4%)          0/21 (0%)          0/9 (0%)           0/0                  |
|FIRST INCIDENCE (DAYS) |         696                659                650                552                456 (I)             |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P=0.611            P=0.543N           P=0.525N           P=0.557N           P=0.695              |
|INCIDENTAL TUMOR       |        P=0.559N           P=0.537N           P=0.415N           P=0.409N           P=0.695              |
|LOGISTIC REGRESSION    |        P=0.623N           P=0.558N           P=0.466N           P=0.434N           P=0.523              |
|COCHRAN-ARMITAGE       |        P=0.328N                                                                                         |
|FISHER EXACT           |                           P=0.655N           P=0.507N           P=0.380N           P=0.530N             |
|=================================================================================================================================|
         DATE: 05/19/95                     EXPERIMENT: 05061 TEST: 01                                                 PAGE   4
                   STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE RATS(FISCHER344) -- 1-AMINO 2,4-DIBROMOANTHRAQUINONE
                       TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE                   |         UNTREATE           0.2%               0.5%               1.0%               2.0%                |
|                       |         D 71 UM            71LM               71MLM              71MHM              MALE                |
|=================================================================================================================================|
|                                                                                                                                 |
|Intestine Large: Colon/Rectum                                                                                                    |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |          #                  #                  #                  #                  #                  |
|-----------            |                                                                                                         |
|OVERALL (a)            |        0/70 (0%)          1/50 (2%)         11/69 (16%)        17/70 (24%)         2/40 (5%)            |
|ADJUSTED (b)           |         0.0%               3.8%              36.6%              67.1%               7.7%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 2 (c)|        0/10 (0%)          0/0                0/0                0/10 (0%)          1/24 (4%)            |
|TERMINAL (d)           |        0/26 (0%)          0/24 (0%)          6/21 (29%)         4/10 (40%)         0/0                  |
|FIRST INCIDENCE (DAYS) |         ---                718                608                493                427                 |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P<0.001 **         P=0.478            P<0.001 **         P<0.001 **         P=0.230              |
|INCIDENTAL TUMOR       |        P<0.001 **         P=0.484            P=0.001 **         P<0.001 **         P=0.386              |
|LOGISTIC REGRESSION    |        P<0.001 **         P=0.480            P=0.001 **         P<0.001 **         P=0.197              |
|COCHRAN-ARMITAGE       |        P=0.037 *                                                                                        |
|FISHER EXACT           |                           P=0.417            P<0.001 **         P<0.001 **         P=0.130              |
|=================================================================================================================================|
|                                                                                                                                 |
|Intestine Large: Colon/Rectum                                                                                                    |
|     Polyp Adenomatous                                                                                                           |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |          #                  #                  #                  #                  #                  |
|-----------            |                                                                                                         |
|OVERALL (a)            |        0/70 (0%)         13/50 (26%)        51/69 (74%)        46/70 (66%)        11/40 (28%)           |
|ADJUSTED (b)           |         0.0%              45.8%             100.0%             100.0%              41.2%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          1/10 (10%)           |
|INTERIM SACRIFICE 2 (c)|        0/10 (0%)          0/0                0/0                6/10 (60%)         9/24 (38%)           |
|TERMINAL (d)           |        0/26 (0%)          9/24 (38%)        21/21 (100%)       10/10 (100%)        0/0                  |
|FIRST INCIDENCE (DAYS) |         ---                659                478                352                273 (I)             |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P<0.001 **         P<0.001 **         P<0.001 **         P<0.001 **         P=0.008 **           |
|INCIDENTAL TUMOR       |        P<0.001 **         P<0.001 **         P<0.001 **         P<0.001 **         P=0.014 *            |
|LOGISTIC REGRESSION    |        P<0.001 **         P<0.001 **         P<0.001 **         P<0.001 **         P<0.001 **           |
|COCHRAN-ARMITAGE       |        P<0.001 **                                                                                       |
|FISHER EXACT           |                           P<0.001 **         P<0.001 **         P<0.001 **         P<0.001 **           |
|=================================================================================================================================|
         DATE: 05/19/95                     EXPERIMENT: 05061 TEST: 01                                                 PAGE   5
                   STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE RATS(FISCHER344) -- 1-AMINO 2,4-DIBROMOANTHRAQUINONE
                       TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE                   |         UNTREATE           0.2%               0.5%               1.0%               2.0%                |
|                       |         D 71 UM            71LM               71MLM              71MHM              MALE                |
|=================================================================================================================================|
|                                                                                                                                 |
|Islets, Pancreatic                                                                                                               |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                                                                         |
|-----------            |                                                                                                         |
|OVERALL (a)            |        2/54 (4%)          2/40 (5%)          0/58 (0%)          1/50 (2%)          0/6 (0%)             |
|ADJUSTED (b)           |         7.7%               7.4%               0.0%              10.0%               0.0%                |
|INTERIM SACRIFICE 1 (c)|        0/0                0/0                0/0                0/0                0/0                  |
|INTERIM SACRIFICE 2 (c)|        0/4 (0%)           0/0                0/0                0/0                0/0                  |
|TERMINAL (d)           |        2/26 (8%)          1/24 (4%)          0/21 (0%)          1/10 (10%)         0/0                  |
|FIRST INCIDENCE (DAYS) |         729 (T)            675                ---                729 (T)            ---                 |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P=0.654N           P=0.664            P=0.286N           P=0.671              (e)                |
|INCIDENTAL TUMOR       |        P=0.610N           P=0.665            P=0.286N           P=0.671              (e)                |
|LOGISTIC REGRESSION    |        P=0.548N           P=0.659            P=0.286N           P=0.671              (e)                |
|COCHRAN-ARMITAGE       |        P=0.316N                                                                                         |
|FISHER EXACT           |                           P=0.571            P=0.230N           P=0.529N           P=0.808N             |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney: Renal Tubule                                                                                                             |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                                                                         |
|-----------            |                                                                                                         |
|OVERALL (a)            |        2/70 (3%)         10/50 (20%)        11/69 (16%)        16/70 (23%)         5/40 (13%)           |
|ADJUSTED (b)           |         7.7%              33.6%              34.6%              69.5%              20.8%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 2 (c)|        0/10 (0%)          0/0                0/0                2/10 (20%)         5/24 (21%)           |
|TERMINAL (d)           |        2/26 (8%)          6/24 (25%)         4/21 (19%)         5/10 (50%)         0/0                  |
|FIRST INCIDENCE (DAYS) |         729 (T)            618                636                456 (I)            456 (I)             |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P<0.001 **         P=0.012 *          P=0.007 **         P<0.001 **         P=0.155              |
|INCIDENTAL TUMOR       |        P<0.001 **         P=0.009 **         P=0.018 *          P<0.001 **         P=0.155              |
|LOGISTIC REGRESSION    |        P<0.001 **         P=0.007 **         P=0.012 *          P<0.001 **         P=0.019 *            |
|COCHRAN-ARMITAGE       |        P=0.132                                                                                          |
|FISHER EXACT           |                           P=0.003 **         P=0.008 **         P<0.001 **         P=0.059              |
|=================================================================================================================================|
         DATE: 05/19/95                     EXPERIMENT: 05061 TEST: 01                                                 PAGE   6
                   STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE RATS(FISCHER344) -- 1-AMINO 2,4-DIBROMOANTHRAQUINONE
                       TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE                   |         UNTREATE           0.2%               0.5%               1.0%               2.0%                |
|                       |         D 71 UM            71LM               71MLM              71MHM              MALE                |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney: Renal Tubule                                                                                                             |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                                                                         |
|-----------            |                                                                                                         |
|OVERALL (a)            |        0/70 (0%)          0/50 (0%)          2/69 (3%)          1/70 (1%)          0/40 (0%)            |
|ADJUSTED (b)           |         0.0%               0.0%               7.2%               2.3%               0.0%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 2 (c)|        0/10 (0%)          0/0                0/0                0/10 (0%)          0/24 (0%)            |
|TERMINAL (d)           |        0/26 (0%)          0/24 (0%)          0/21 (0%)          0/10 (0%)          0/0                  |
|FIRST INCIDENCE (DAYS) |         ---                ---                674                497                ---                 |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P=0.258              (e)              P=0.224            P=0.482              (e)                |
|INCIDENTAL TUMOR       |        P=0.674              (e)              P=0.348            P=0.612              (e)                |
|LOGISTIC REGRESSION    |        P=0.559              (e)              P=0.252            P=0.517              (e)                |
|COCHRAN-ARMITAGE       |        P=0.659                                                                                          |
|FISHER EXACT           |                             (e)              P=0.245            P=0.500              (e)                |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney: Renal Tubule                                                                                                             |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                                                                         |
|-----------            |                                                                                                         |
|OVERALL (a)            |        2/70 (3%)         10/50 (20%)        13/69 (19%)        17/70 (24%)         5/40 (13%)           |
|ADJUSTED (b)           |         7.7%              33.6%              39.4%              70.2%              20.8%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 2 (c)|        0/10 (0%)          0/0                0/0                2/10 (20%)         5/24 (21%)           |
|TERMINAL (d)           |        2/26 (8%)          6/24 (25%)         4/21 (19%)         5/10 (50%)         0/0                  |
|FIRST INCIDENCE (DAYS) |         729 (T)            618                636                456 (I)            456 (I)             |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P<0.001 **         P=0.012 *          P=0.002 **         P<0.001 **         P=0.155              |
|INCIDENTAL TUMOR       |        P<0.001 **         P=0.009 **         P=0.008 **         P<0.001 **         P=0.155              |
|LOGISTIC REGRESSION    |        P<0.001 **         P=0.007 **         P=0.004 **         P<0.001 **         P=0.019 *            |
|COCHRAN-ARMITAGE       |        P=0.136                                                                                          |
|FISHER EXACT           |                           P=0.003 **         P=0.002 **         P<0.001 **         P=0.059              |
|=================================================================================================================================|
         DATE: 05/19/95                     EXPERIMENT: 05061 TEST: 01                                                 PAGE   7
                   STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE RATS(FISCHER344) -- 1-AMINO 2,4-DIBROMOANTHRAQUINONE
                       TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE                   |         UNTREATE           0.2%               0.5%               1.0%               2.0%                |
|                       |         D 71 UM            71LM               71MLM              71MHM              MALE                |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Cholangioma                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                                                                         |
|-----------            |                                                                                                         |
|OVERALL (a)            |        0/70 (0%)          0/50 (0%)          2/69 (3%)          0/70 (0%)          0/40 (0%)            |
|ADJUSTED (b)           |         0.0%               0.0%               7.0%               0.0%               0.0%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 2 (c)|        0/10 (0%)          0/0                0/0                0/10 (0%)          0/24 (0%)            |
|TERMINAL (d)           |        0/26 (0%)          0/24 (0%)          1/21 (5%)          0/10 (0%)          0/0                  |
|FIRST INCIDENCE (DAYS) |         ---                ---                650                ---                ---                 |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P=0.651              (e)              P=0.227              (e)                (e)                |
|INCIDENTAL TUMOR       |        P=0.706              (e)              P=0.266              (e)                (e)                |
|LOGISTIC REGRESSION    |        P=0.743              (e)              P=0.253              (e)                (e)                |
|COCHRAN-ARMITAGE       |        P=0.587N                                                                                         |
|FISHER EXACT           |                             (e)              P=0.245              (e)                (e)                |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Adenoma                                                                                                      |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                                                                         |
|-----------            |                                                                                                         |
|OVERALL (a)            |        1/70 (1%)         20/50 (40%)        41/69 (59%)        38/70 (54%)        17/40 (43%)           |
|ADJUSTED (b)           |         3.8%              71.3%              92.4%              97.2%              57.5%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          1/10 (10%)         0/10 (0%)          2/10 (20%)           |
|INTERIM SACRIFICE 2 (c)|        0/10 (0%)          0/0                0/0                4/10 (40%)        12/24 (50%)           |
|TERMINAL (d)           |        1/26 (4%)         16/24 (67%)        18/21 (86%)         9/10 (90%)         0/0                  |
|FIRST INCIDENCE (DAYS) |         729 (T)            675                273 (I)            435                273 (I)             |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P<0.001 **         P<0.001 **         P<0.001 **         P<0.001 **         P<0.001 **           |
|INCIDENTAL TUMOR       |        P<0.001 **         P<0.001 **         P<0.001 **         P<0.001 **         P<0.001 **           |
|LOGISTIC REGRESSION    |        P<0.001 **         P<0.001 **         P<0.001 **         P<0.001 **         P<0.001 **           |
|COCHRAN-ARMITAGE       |        P<0.001 **                                                                                       |
|FISHER EXACT           |                           P<0.001 **         P<0.001 **         P<0.001 **         P<0.001 **           |
|=================================================================================================================================|
         DATE: 05/19/95                     EXPERIMENT: 05061 TEST: 01                                                 PAGE   8
                   STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE RATS(FISCHER344) -- 1-AMINO 2,4-DIBROMOANTHRAQUINONE
                       TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE                   |         UNTREATE           0.2%               0.5%               1.0%               2.0%                |
|                       |         D 71 UM            71LM               71MLM              71MHM              MALE                |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma                                                                                                    |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                                                                         |
|-----------            |                                                                                                         |
|OVERALL (a)            |        1/70 (1%)         12/50 (24%)        55/69 (80%)        53/70 (76%)        28/40 (70%)           |
|ADJUSTED (b)           |         2.7%              43.5%             100.0%             100.0%              90.2%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          2/10 (20%)           |
|INTERIM SACRIFICE 2 (c)|        0/10 (0%)          0/0                0/0                7/10 (70%)        21/24 (88%)           |
|TERMINAL (d)           |        0/26 (0%)          9/24 (38%)        21/21 (100%)       10/10 (100%)        0/0                  |
|FIRST INCIDENCE (DAYS) |         666                650                465                436                273 (I)             |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P<0.001 **         P<0.001 **         P<0.001 **         P<0.001 **         P<0.001 **           |
|INCIDENTAL TUMOR       |        P<0.001 **         P<0.001 **         P<0.001 **         P<0.001 **         P<0.001 **           |
|LOGISTIC REGRESSION    |        P<0.001 **         P<0.001 **         P<0.001 **         P<0.001 **         P<0.001 **           |
|COCHRAN-ARMITAGE       |        P<0.001 **                                                                                       |
|FISHER EXACT           |                           P<0.001 **         P<0.001 **         P<0.001 **         P<0.001 **           |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma or Hepatocellular Adenoma                                                                          |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                                                                         |
|-----------            |                                                                                                         |
|OVERALL (a)            |        2/70 (3%)         25/50 (50%)        58/69 (84%)        57/70 (81%)        33/40 (83%)           |
|ADJUSTED (b)           |         6.4%              83.1%             100.0%             100.0%              97.0%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          1/10 (10%)         0/10 (0%)          4/10 (40%)           |
|INTERIM SACRIFICE 2 (c)|        0/10 (0%)          0/0                0/0               10/10 (100%)       23/24 (96%)           |
|TERMINAL (d)           |        1/26 (4%)         19/24 (79%)        21/21 (100%)       10/10 (100%)        0/0                  |
|FIRST INCIDENCE (DAYS) |         666                650                273 (I)            435                273 (I)             |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P<0.001 **         P<0.001 **         P<0.001 **         P<0.001 **         P<0.001 **           |
|INCIDENTAL TUMOR       |        P<0.001 **         P<0.001 **         P<0.001 **         P<0.001 **         P<0.001 **           |
|LOGISTIC REGRESSION    |        P<0.001 **         P<0.001 **         P<0.001 **         P<0.001 **         P<0.001 **           |
|COCHRAN-ARMITAGE       |        P<0.001 **                                                                                       |
|FISHER EXACT           |                           P<0.001 **         P<0.001 **         P<0.001 **         P<0.001 **           |
|=================================================================================================================================|
         DATE: 05/19/95                     EXPERIMENT: 05061 TEST: 01                                                 PAGE   9
                   STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE RATS(FISCHER344) -- 1-AMINO 2,4-DIBROMOANTHRAQUINONE
                       TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE                   |         UNTREATE           0.2%               0.5%               1.0%               2.0%                |
|                       |         D 71 UM            71LM               71MLM              71MHM              MALE                |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma                                                         |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                                                                         |
|-----------            |                                                                                                         |
|OVERALL (a)            |        2/70 (3%)         25/50 (50%)        58/69 (84%)        57/70 (81%)        33/40 (83%)           |
|ADJUSTED (b)           |         6.4%              83.1%             100.0%             100.0%              97.0%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          1/10 (10%)         0/10 (0%)          4/10 (40%)           |
|INTERIM SACRIFICE 2 (c)|        0/10 (0%)          0/0                0/0               10/10 (100%)       23/24 (96%)           |
|TERMINAL (d)           |        1/26 (4%)         19/24 (79%)        21/21 (100%)       10/10 (100%)        0/0                  |
|FIRST INCIDENCE (DAYS) |         666                650                273 (I)            435                273 (I)             |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P<0.001 **         P<0.001 **         P<0.001 **         P<0.001 **         P<0.001 **           |
|INCIDENTAL TUMOR       |        P<0.001 **         P<0.001 **         P<0.001 **         P<0.001 **         P<0.001 **           |
|LOGISTIC REGRESSION    |        P<0.001 **         P<0.001 **         P<0.001 **         P<0.001 **         P<0.001 **           |
|COCHRAN-ARMITAGE       |        P<0.001 **                                                                                       |
|FISHER EXACT           |                           P<0.001 **         P<0.001 **         P<0.001 **         P<0.001 **           |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocholangiocarcinoma                                                                                                    |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                                                                         |
|-----------            |                                                                                                         |
|OVERALL (a)            |        0/70 (0%)          0/50 (0%)          6/69 (9%)          2/70 (3%)          1/40 (3%)            |
|ADJUSTED (b)           |         0.0%               0.0%              19.1%              12.1%               3.4%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 2 (c)|        0/10 (0%)          0/0                0/0                0/10 (0%)          0/24 (0%)            |
|TERMINAL (d)           |        0/26 (0%)          0/24 (0%)          2/21 (10%)         1/10 (10%)         0/0                  |
|FIRST INCIDENCE (DAYS) |         ---                ---                563                527                414                 |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P=0.004 **           (e)              P=0.019 *          P=0.133            P=0.355              |
|INCIDENTAL TUMOR       |        P=0.134              (e)              P=0.039 *          P=0.186            P=0.581              |
|LOGISTIC REGRESSION    |        P=0.126              (e)              P=0.022 *          P=0.210            P=0.499              |
|COCHRAN-ARMITAGE       |        P=0.367                                                                                          |
|FISHER EXACT           |                             (e)              P=0.013 *          P=0.248            P=0.364              |
|=================================================================================================================================|
         DATE: 05/19/95                     EXPERIMENT: 05061 TEST: 01                                                 PAGE  10
                   STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE RATS(FISCHER344) -- 1-AMINO 2,4-DIBROMOANTHRAQUINONE
                       TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE                   |         UNTREATE           0.2%               0.5%               1.0%               2.0%                |
|                       |         D 71 UM            71LM               71MLM              71MHM              MALE                |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocholangioma                                                                                                           |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                                                                         |
|-----------            |                                                                                                         |
|OVERALL (a)            |        0/70 (0%)          0/50 (0%)          1/69 (1%)          1/70 (1%)          0/40 (0%)            |
|ADJUSTED (b)           |         0.0%               0.0%               2.1%               3.4%               0.0%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 2 (c)|        0/10 (0%)          0/0                0/0                0/10 (0%)          0/24 (0%)            |
|TERMINAL (d)           |        0/26 (0%)          0/24 (0%)          0/21 (0%)          0/10 (0%)          0/0                  |
|FIRST INCIDENCE (DAYS) |         ---                ---                629                622                ---                 |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P=0.318              (e)              P=0.532            P=0.436              (e)                |
|INCIDENTAL TUMOR       |        P=0.621              (e)              P=0.623            P=0.665              (e)                |
|LOGISTIC REGRESSION    |        P=0.561              (e)              P=0.504            P=0.480              (e)                |
|COCHRAN-ARMITAGE       |        P=0.631                                                                                          |
|FISHER EXACT           |                             (e)              P=0.496            P=0.500              (e)                |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Adenoma                                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                                                                         |
|-----------            |                                                                                                         |
|OVERALL (a)            |        1/70 (1%)          2/50 (4%)          2/69 (3%)          4/62 (6%)          1/40 (3%)            |
|ADJUSTED (b)           |         1.8%               8.3%               7.2%              17.1%               2.5%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          1/10 (10%)           |
|INTERIM SACRIFICE 2 (c)|        1/10 (10%)         0/0                0/0                1/3 (33%)          0/24 (0%)            |
|TERMINAL (d)           |        0/26 (0%)          2/24 (8%)          1/21 (5%)          1/10 (10%)         0/0                  |
|FIRST INCIDENCE (DAYS) |         456 (I)            729 (T)            653                456 (I)            273 (I)             |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P=0.277            P=0.220            P=0.219            P=0.030 *          P=0.668N             |
|INCIDENTAL TUMOR       |        P=0.470            P=0.220            P=0.266            P=0.072            P=0.668N             |
|LOGISTIC REGRESSION    |        P=0.320            P=0.400            P=0.500            P=0.149            P=0.736N             |
|COCHRAN-ARMITAGE       |        P=0.403                                                                                          |
|FISHER EXACT           |                           P=0.375            P=0.495            P=0.147            P=0.597              |
|=================================================================================================================================|
         DATE: 05/19/95                     EXPERIMENT: 05061 TEST: 01                                                 PAGE  11
                   STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE RATS(FISCHER344) -- 1-AMINO 2,4-DIBROMOANTHRAQUINONE
                       TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE                   |         UNTREATE           0.2%               0.5%               1.0%               2.0%                |
|                       |         D 71 UM            71LM               71MLM              71MHM              MALE                |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Carcinoma                                                                                              |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                                                                         |
|-----------            |                                                                                                         |
|OVERALL (a)            |        0/70 (0%)          1/50 (2%)          2/69 (3%)          1/62 (2%)          0/40 (0%)            |
|ADJUSTED (b)           |         0.0%               4.0%               9.5%               1.8%               0.0%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 2 (c)|        0/10 (0%)          0/0                0/0                0/3 (0%)           0/24 (0%)            |
|TERMINAL (d)           |        0/26 (0%)          0/24 (0%)          2/21 (10%)         0/10 (0%)          0/0                  |
|FIRST INCIDENCE (DAYS) |         ---                720                729 (T)            435                ---                 |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P=0.434            P=0.470            P=0.192            P=0.497              (e)                |
|INCIDENTAL TUMOR       |        P=0.657            P=0.484            P=0.192            P=0.612              (e)                |
|LOGISTIC REGRESSION    |        P=0.630            P=0.480            P=0.192            P=0.499              (e)                |
|COCHRAN-ARMITAGE       |        P=0.542N                                                                                         |
|FISHER EXACT           |                           P=0.417            P=0.245            P=0.470              (e)                |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma                                                              |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                                                                         |
|-----------            |                                                                                                         |
|OVERALL (a)            |        1/70 (1%)          3/50 (6%)          4/69 (6%)          5/62 (8%)          1/40 (3%)            |
|ADJUSTED (b)           |         1.8%              12.0%              16.5%              18.6%               2.5%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          1/10 (10%)           |
|INTERIM SACRIFICE 2 (c)|        1/10 (10%)         0/0                0/0                1/3 (33%)          0/24 (0%)            |
|TERMINAL (d)           |        0/26 (0%)          2/24 (8%)          3/21 (14%)         1/10 (10%)         0/0                  |
|FIRST INCIDENCE (DAYS) |         456 (I)            720                653                435                273 (I)             |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P=0.191            P=0.105            P=0.046 *          P=0.017 *          P=0.668N             |
|INCIDENTAL TUMOR       |        P=0.448            P=0.109            P=0.056            P=0.047 *          P=0.668N             |
|LOGISTIC REGRESSION    |        P=0.311            P=0.220            P=0.196            P=0.085            P=0.736N             |
|COCHRAN-ARMITAGE       |        P=0.478                                                                                          |
|FISHER EXACT           |                           P=0.195            P=0.178            P=0.079            P=0.597              |
|=================================================================================================================================|
         DATE: 05/19/95                     EXPERIMENT: 05061 TEST: 01                                                 PAGE  12
                   STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE RATS(FISCHER344) -- 1-AMINO 2,4-DIBROMOANTHRAQUINONE
                       TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE                   |         UNTREATE           0.2%               0.5%               1.0%               2.0%                |
|                       |         D 71 UM            71LM               71MLM              71MHM              MALE                |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |          #                  #                  #                  #                  #                  |
|-----------            |                                                                                                         |
|OVERALL (a)            |        0/70 (0%)          0/50 (0%)          1/69 (1%)          0/70 (0%)          0/40 (0%)            |
|ADJUSTED (b)           |         0.0%               0.0%               2.8%               0.0%               0.0%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 2 (c)|        0/10 (0%)          0/0                0/0                0/10 (0%)          0/24 (0%)            |
|TERMINAL (d)           |        0/26 (0%)          0/24 (0%)          0/21 (0%)          0/10 (0%)          0/0                  |
|FIRST INCIDENCE (DAYS) |         ---                ---                674                ---                ---                 |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P=0.858              (e)              P=0.506              (e)                (e)                |
|INCIDENTAL TUMOR       |        P=0.895              (e)              P=0.596              (e)                (e)                |
|LOGISTIC REGRESSION    |        P=0.864              (e)              P=0.513              (e)                (e)                |
|COCHRAN-ARMITAGE       |        P=0.708N                                                                                         |
|FISHER EXACT           |                             (e)              P=0.496              (e)                (e)                |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Fibroadenoma                                                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |          #                  #                  #                  #                  #                  |
|-----------            |                                                                                                         |
|OVERALL (a)            |        1/70 (1%)          1/50 (2%)          0/69 (0%)          0/70 (0%)          0/40 (0%)            |
|ADJUSTED (b)           |         3.1%               4.2%               0.0%               0.0%               0.0%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 2 (c)|        0/10 (0%)          0/0                0/0                0/10 (0%)          0/24 (0%)            |
|TERMINAL (d)           |        0/26 (0%)          1/24 (4%)          0/21 (0%)          0/10 (0%)          0/0                  |
|FIRST INCIDENCE (DAYS) |         692                729 (T)            ---                ---                ---                 |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P=0.526N           P=0.740            P=0.506N           P=0.615N             (e)                |
|INCIDENTAL TUMOR       |        P=0.450N           P=0.742            P=0.404N           P=0.485N             (e)                |
|LOGISTIC REGRESSION    |        P=0.451N           P=0.737            P=0.486N           P=0.568N           P=0.998N             |
|COCHRAN-ARMITAGE       |        P=0.253N                                                                                         |
|FISHER EXACT           |                           P=0.662            P=0.504N           P=0.500N           P=0.636N             |
|=================================================================================================================================|
         DATE: 05/19/95                     EXPERIMENT: 05061 TEST: 01                                                 PAGE  13
                   STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE RATS(FISCHER344) -- 1-AMINO 2,4-DIBROMOANTHRAQUINONE
                       TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE                   |         UNTREATE           0.2%               0.5%               1.0%               2.0%                |
|                       |         D 71 UM            71LM               71MLM              71MHM              MALE                |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Fibroma, Fibroadenoma or Adenoma                                                                                            |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |          #                  #                  #                  #                  #                  |
|-----------            |                                                                                                         |
|OVERALL (a)            |        1/70 (1%)          1/50 (2%)          0/69 (0%)          0/70 (0%)          0/40 (0%)            |
|ADJUSTED (b)           |         3.1%               4.2%               0.0%               0.0%               0.0%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 2 (c)|        0/10 (0%)          0/0                0/0                0/10 (0%)          0/24 (0%)            |
|TERMINAL (d)           |        0/26 (0%)          1/24 (4%)          0/21 (0%)          0/10 (0%)          0/0                  |
|FIRST INCIDENCE (DAYS) |         692                729 (T)            ---                ---                ---                 |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P=0.526N           P=0.740            P=0.506N           P=0.615N             (e)                |
|INCIDENTAL TUMOR       |        P=0.450N           P=0.742            P=0.404N           P=0.485N             (e)                |
|LOGISTIC REGRESSION    |        P=0.451N           P=0.737            P=0.486N           P=0.568N           P=0.998N             |
|COCHRAN-ARMITAGE       |        P=0.253N                                                                                         |
|FISHER EXACT           |                           P=0.662            P=0.504N           P=0.500N           P=0.636N             |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Fibroma, Fibroadenoma, Carcinoma, or Adenoma                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |          #                  #                  #                  #                  #                  |
|-----------            |                                                                                                         |
|OVERALL (a)            |        1/70 (1%)          1/50 (2%)          1/69 (1%)          0/70 (0%)          0/40 (0%)            |
|ADJUSTED (b)           |         3.1%               4.2%               2.8%               0.0%               0.0%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 2 (c)|        0/10 (0%)          0/0                0/0                0/10 (0%)          0/24 (0%)            |
|TERMINAL (d)           |        0/26 (0%)          1/24 (4%)          0/21 (0%)          0/10 (0%)          0/0                  |
|FIRST INCIDENCE (DAYS) |         692                729 (T)            674                ---                ---                 |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P=0.607N           P=0.740            P=0.760            P=0.615N             (e)                |
|INCIDENTAL TUMOR       |        P=0.494N           P=0.742            P=0.652N           P=0.485N             (e)                |
|LOGISTIC REGRESSION    |        P=0.484N           P=0.737            P=0.747N           P=0.568N           P=0.998N             |
|COCHRAN-ARMITAGE       |        P=0.248N                                                                                         |
|FISHER EXACT           |                           P=0.662            P=0.748            P=0.500N           P=0.636N             |
|=================================================================================================================================|
         DATE: 05/19/95                     EXPERIMENT: 05061 TEST: 01                                                 PAGE  14
                   STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE RATS(FISCHER344) -- 1-AMINO 2,4-DIBROMOANTHRAQUINONE
                       TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE                   |         UNTREATE           0.2%               0.5%               1.0%               2.0%                |
|                       |         D 71 UM            71LM               71MLM              71MHM              MALE                |
|=================================================================================================================================|
|                                                                                                                                 |
|Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Gingiva)                                                                       |
|     Squamous Cell Carcinoma, Papilloma Squamous, or Papilloma                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |          #                  #                  #                  #                  #                  |
|-----------            |                                                                                                         |
|OVERALL (a)            |        0/70 (0%)          0/50 (0%)          0/69 (0%)          0/70 (0%)          0/40 (0%)            |
|ADJUSTED (b)           |         0.0%               0.0%               0.0%               0.0%               0.0%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 2 (c)|        0/10 (0%)          0/0                0/0                0/10 (0%)          0/24 (0%)            |
|TERMINAL (d)           |        0/26 (0%)          0/24 (0%)          0/21 (0%)          0/10 (0%)          0/0                  |
|FIRST INCIDENCE (DAYS) |         ---                ---                ---                ---                ---                 |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |          (e)                (e)                (e)                (e)                (e)                |
|INCIDENTAL TUMOR       |          (e)                (e)                (e)                (e)                (e)                |
|LOGISTIC REGRESSION    |          (e)                (e)                (e)                (e)                (e)                |
|COCHRAN-ARMITAGE       |          (e)                                                                                            |
|FISHER EXACT           |                             (e)                (e)                (e)                (e)                |
|=================================================================================================================================|
|                                                                                                                                 |
|Pancreas                                                                                                                         |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                                                                         |
|-----------            |                                                                                                         |
|OVERALL (a)            |        3/70 (4%)          0/50 (0%)          0/69 (0%)          0/60 (0%)          0/40 (0%)            |
|ADJUSTED (b)           |         9.3%               0.0%               0.0%               0.0%               0.0%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 2 (c)|        1/10 (10%)         0/0                0/0                0/0                0/24 (0%)            |
|TERMINAL (d)           |        2/26 (8%)          0/24 (0%)          0/21 (0%)          0/10 (0%)          0/0                  |
|FIRST INCIDENCE (DAYS) |         456 (I)            ---                ---                ---                ---                 |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P=0.065N           P=0.255N           P=0.286N           P=0.465N           P=0.326N             |
|INCIDENTAL TUMOR       |        P=0.065N           P=0.255N           P=0.286N           P=0.465N           P=0.326N             |
|LOGISTIC REGRESSION    |        P=0.104N           P=0.174N           P=0.116N           P=0.162N           P=0.522N             |
|COCHRAN-ARMITAGE       |        P=0.103N                                                                                         |
|FISHER EXACT           |                           P=0.195N           P=0.125N           P=0.153N           P=0.254N             |
|=================================================================================================================================|
         DATE: 05/19/95                     EXPERIMENT: 05061 TEST: 01                                                 PAGE  15
                   STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE RATS(FISCHER344) -- 1-AMINO 2,4-DIBROMOANTHRAQUINONE
                       TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE                   |         UNTREATE           0.2%               0.5%               1.0%               2.0%                |
|                       |         D 71 UM            71LM               71MLM              71MHM              MALE                |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                                                                         |
|-----------            |                                                                                                         |
|OVERALL (a)            |       22/65 (34%)        14/50 (28%)        10/65 (15%)        10/58 (17%)         1/39 (3%)            |
|ADJUSTED (b)           |        57.0%              40.8%              33.0%              51.1%               4.2%                |
|INTERIM SACRIFICE 1 (c)|        0/9 (0%)           0/10 (0%)          0/9 (0%)           0/9 (0%)           0/10 (0%)            |
|INTERIM SACRIFICE 2 (c)|        1/8 (13%)          0/0                0/0                0/0                1/23 (4%)            |
|TERMINAL (d)           |       10/25 (40%)         6/24 (25%)         4/21 (19%)         4/10 (40%)         0/0                  |
|FIRST INCIDENCE (DAYS) |         456 (I)            604                608                577                456 (I)             |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P=0.229N           P=0.190N           P=0.041N*          P=0.430N           P=0.511N             |
|INCIDENTAL TUMOR       |        P=0.010N*          P=0.217N           P=0.003N**         P=0.039N*          P=0.511N             |
|LOGISTIC REGRESSION    |        P=0.010N**         P=0.184N           P=0.005N**         P=0.015N*          P=0.183N             |
|COCHRAN-ARMITAGE       |        P<0.001N**                                                                                       |
|FISHER EXACT           |                           P=0.321N           P=0.012N*          P=0.029N*          P<0.001N**           |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                                                                         |
|-----------            |                                                                                                         |
|OVERALL (a)            |       22/65 (34%)        15/50 (30%)        10/65 (15%)        10/58 (17%)         1/39 (3%)            |
|ADJUSTED (b)           |        57.0%              42.3%              33.0%              51.1%               4.2%                |
|INTERIM SACRIFICE 1 (c)|        0/9 (0%)           0/10 (0%)          0/9 (0%)           0/9 (0%)           0/10 (0%)            |
|INTERIM SACRIFICE 2 (c)|        1/8 (13%)          0/0                0/0                0/0                1/23 (4%)            |
|TERMINAL (d)           |       10/25 (40%)         6/24 (25%)         4/21 (19%)         4/10 (40%)         0/0                  |
|FIRST INCIDENCE (DAYS) |         456 (I)            604                608                577                456 (I)             |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P=0.210N           P=0.248N           P=0.041N*          P=0.430N           P=0.511N             |
|INCIDENTAL TUMOR       |        P=0.007N**         P=0.308N           P=0.003N**         P=0.039N*          P=0.511N             |
|LOGISTIC REGRESSION    |        P=0.007N**         P=0.261N           P=0.005N**         P=0.015N*          P=0.183N             |
|COCHRAN-ARMITAGE       |        P<0.001N**                                                                                       |
|FISHER EXACT           |                           P=0.408N           P=0.012N*          P=0.029N*          P<0.001N**           |
|=================================================================================================================================|
         DATE: 05/19/95                     EXPERIMENT: 05061 TEST: 01                                                 PAGE  16
                   STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE RATS(FISCHER344) -- 1-AMINO 2,4-DIBROMOANTHRAQUINONE
                       TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE                   |         UNTREATE           0.2%               0.5%               1.0%               2.0%                |
|                       |         D 71 UM            71LM               71MLM              71MHM              MALE                |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Basal Cell Carcinoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |          #                  #                  #                  #                  #                  |
|-----------            |                                                                                                         |
|OVERALL (a)            |        2/70 (3%)          0/50 (0%)          0/69 (0%)          0/70 (0%)          0/40 (0%)            |
|ADJUSTED (b)           |         7.7%               0.0%               0.0%               0.0%               0.0%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 2 (c)|        0/10 (0%)          0/0                0/0                0/10 (0%)          0/24 (0%)            |
|TERMINAL (d)           |        2/26 (8%)          0/24 (0%)          0/21 (0%)          0/10 (0%)          0/0                  |
|FIRST INCIDENCE (DAYS) |         729 (T)            ---                ---                ---                ---                 |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P=0.391N           P=0.255N           P=0.286N           P=0.465N             (e)                |
|INCIDENTAL TUMOR       |        P=0.391N           P=0.255N           P=0.286N           P=0.465N             (e)                |
|LOGISTIC REGRESSION    |        P=0.391N           P=0.255N           P=0.286N           P=0.465N             (e)                |
|COCHRAN-ARMITAGE       |        P=0.188N                                                                                         |
|FISHER EXACT           |                           P=0.338N           P=0.252N           P=0.248N           P=0.403N             |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Basal Cell Carcinoma, Basal Cell Adenoma, Basosquamous Tumor (benign,                                                       |
|     malignant or NOS), or Trichoepithelioma                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |          #                  #                  #                  #                  #                  |
|-----------            |                                                                                                         |
|OVERALL (a)            |        3/70 (4%)          0/50 (0%)          1/69 (1%)          1/70 (1%)          0/40 (0%)            |
|ADJUSTED (b)           |        11.5%               0.0%               4.3%               5.0%               0.0%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 2 (c)|        0/10 (0%)          0/0                0/0                0/10 (0%)          0/24 (0%)            |
|TERMINAL (d)           |        3/26 (12%)         0/24 (0%)          0/21 (0%)          0/10 (0%)          0/0                  |
|FIRST INCIDENCE (DAYS) |         729 (T)            ---                720                679                ---                 |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P=0.693N           P=0.134N           P=0.386N           P=0.627N             (e)                |
|INCIDENTAL TUMOR       |        P=0.589N           P=0.134N           P=0.319N           P=0.565N             (e)                |
|LOGISTIC REGRESSION    |        P=0.593N           P=0.134N           P=0.351N           P=0.503N             (e)                |
|COCHRAN-ARMITAGE       |        P=0.189N                                                                                         |
|FISHER EXACT           |                           P=0.195N           P=0.315N           P=0.310N           P=0.254N             |
|=================================================================================================================================|
         DATE: 05/19/95                     EXPERIMENT: 05061 TEST: 01                                                 PAGE  17
                   STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE RATS(FISCHER344) -- 1-AMINO 2,4-DIBROMOANTHRAQUINONE
                       TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE                   |         UNTREATE           0.2%               0.5%               1.0%               2.0%                |
|                       |         D 71 UM            71LM               71MLM              71MHM              MALE                |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Basal or Sq. Cell Carcinoma, Carcinoma, Basosq. Tumor (M or B), Basal                                                       |
|     Cell Adenoma, Adenoma, Papilloma, Sq Papilloma, Keratoacanthoma, Trichoepithelioma                                          |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |          #                  #                  #                  #                  #                  |
|-----------            |                                                                                                         |
|OVERALL (a)            |        5/70 (7%)          3/50 (6%)          6/69 (9%)          4/70 (6%)          0/40 (0%)            |
|ADJUSTED (b)           |        18.0%              10.1%              22.5%              17.0%               0.0%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 2 (c)|        0/10 (0%)          0/0                0/0                0/10 (0%)          0/24 (0%)            |
|TERMINAL (d)           |        4/26 (15%)         1/24 (4%)          2/21 (10%)         0/10 (0%)          0/0                  |
|FIRST INCIDENCE (DAYS) |         692                629                693                527                ---                 |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P=0.259            P=0.403N           P=0.394            P=0.377              (e)                |
|INCIDENTAL TUMOR       |        P=0.577N           P=0.435N           P=0.570            P=0.593              (e)                |
|LOGISTIC REGRESSION    |        P=0.580            P=0.425N           P=0.493            P=0.589              (e)                |
|COCHRAN-ARMITAGE       |        P=0.085N                                                                                         |
|FISHER EXACT           |                           P=0.556N           P=0.490            P=0.500N           P=0.099N             |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Fibroma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |          #                  #                  #                  #                  #                  |
|-----------            |                                                                                                         |
|OVERALL (a)            |        2/70 (3%)          0/50 (0%)          3/69 (4%)          1/70 (1%)          0/40 (0%)            |
|ADJUSTED (b)           |         6.3%               0.0%              12.9%               3.8%               0.0%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 2 (c)|        0/10 (0%)          0/0                0/0                0/10 (0%)          0/24 (0%)            |
|TERMINAL (d)           |        1/26 (4%)          0/24 (0%)          1/21 (5%)          0/10 (0%)          0/0                  |
|FIRST INCIDENCE (DAYS) |         646                ---                715                631                ---                 |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P=0.511            P=0.257N           P=0.437            P=0.707N             (e)                |
|INCIDENTAL TUMOR       |        P=0.701N           P=0.258N           P=0.591            P=0.504N             (e)                |
|LOGISTIC REGRESSION    |        P=0.701            P=0.277N           P=0.520            P=0.581N           P=0.945N             |
|COCHRAN-ARMITAGE       |        P=0.281N                                                                                         |
|FISHER EXACT           |                           P=0.338N           P=0.493            P=0.500N           P=0.403N             |
|=================================================================================================================================|
         DATE: 05/19/95                     EXPERIMENT: 05061 TEST: 01                                                 PAGE  18
                   STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE RATS(FISCHER344) -- 1-AMINO 2,4-DIBROMOANTHRAQUINONE
                       TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE                   |         UNTREATE           0.2%               0.5%               1.0%               2.0%                |
|                       |         D 71 UM            71LM               71MLM              71MHM              MALE                |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Fibroma, Fibrosarcoma, Sarcoma, Myxoma, Myxosarcoma, or Fibrous Histiocytoma                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |          #                  #                  #                  #                  #                  |
|-----------            |                                                                                                         |
|OVERALL (a)            |        4/70 (6%)          3/50 (6%)          5/69 (7%)          1/70 (1%)          0/40 (0%)            |
|ADJUSTED (b)           |        10.7%              11.1%              17.0%               3.8%               0.0%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 2 (c)|        0/10 (0%)          0/0                0/0                0/10 (0%)          0/24 (0%)            |
|TERMINAL (d)           |        1/26 (4%)          1/24 (4%)          1/21 (5%)          0/10 (0%)          0/0                  |
|FIRST INCIDENCE (DAYS) |         562                675                465                631                ---                 |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P=0.494N           P=0.550N           P=0.493            P=0.351N             (e)                |
|INCIDENTAL TUMOR       |        P=0.101N           P=0.616N           P=0.593N           P=0.086N             (e)                |
|LOGISTIC REGRESSION    |        P=0.142N           P=0.622N           P=0.529            P=0.223N           P=0.421N             |
|COCHRAN-ARMITAGE       |        P=0.044N*                                                                                        |
|FISHER EXACT           |                           P=0.620            P=0.491            P=0.183N           P=0.159N             |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Fibrosarcoma, Sarcoma, Myxosarcoma, or Fibrous Histiocytoma                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |          #                  #                  #                  #                  #                  |
|-----------            |                                                                                                         |
|OVERALL (a)            |        2/70 (3%)          3/50 (6%)          2/69 (3%)          0/70 (0%)          0/40 (0%)            |
|ADJUSTED (b)           |         4.7%              11.1%               4.7%               0.0%               0.0%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 2 (c)|        0/10 (0%)          0/0                0/0                0/10 (0%)          0/24 (0%)            |
|TERMINAL (d)           |        0/26 (0%)          1/24 (4%)          0/21 (0%)          0/10 (0%)          0/0                  |
|FIRST INCIDENCE (DAYS) |         562                675                465                ---                ---                 |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P=0.293N           P=0.456            P=0.638N           P=0.304N             (e)                |
|INCIDENTAL TUMOR       |        P=0.064N           P=0.378            P=0.534N           P=0.080N             (e)                |
|LOGISTIC REGRESSION    |        P=0.102N           P=0.391            P=0.684            P=0.247N           P=0.525N             |
|COCHRAN-ARMITAGE       |        P=0.072N                                                                                         |
|FISHER EXACT           |                           P=0.344            P=0.685            P=0.248N           P=0.403N             |
|=================================================================================================================================|
         DATE: 05/19/95                     EXPERIMENT: 05061 TEST: 01                                                 PAGE  19
                   STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE RATS(FISCHER344) -- 1-AMINO 2,4-DIBROMOANTHRAQUINONE
                       TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE                   |         UNTREATE           0.2%               0.5%               1.0%               2.0%                |
|                       |         D 71 UM            71LM               71MLM              71MHM              MALE                |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Sarcoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |          #                  #                  #                  #                  #                  |
|-----------            |                                                                                                         |
|OVERALL (a)            |        1/70 (1%)          3/50 (6%)          1/69 (1%)          0/70 (0%)          0/40 (0%)            |
|ADJUSTED (b)           |         2.3%              11.1%               3.0%               0.0%               0.0%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 2 (c)|        0/10 (0%)          0/0                0/0                0/10 (0%)          0/24 (0%)            |
|TERMINAL (d)           |        0/26 (0%)          1/24 (4%)          0/21 (0%)          0/10 (0%)          0/0                  |
|FIRST INCIDENCE (DAYS) |         562                675                685                ---                ---                 |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P=0.403N           P=0.272            P=0.732N           P=0.529N             (e)                |
|INCIDENTAL TUMOR       |        P=0.208N           P=0.239            P=0.634N           P=0.335N             (e)                |
|LOGISTIC REGRESSION    |        P=0.223N           P=0.228            P=0.760N           P=0.499N           P=0.711N             |
|COCHRAN-ARMITAGE       |        P=0.122N                                                                                         |
|FISHER EXACT           |                           P=0.195            P=0.748            P=0.500N           P=0.636N             |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Squamous Cell Papilloma                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |          #                  #                  #                  #                  #                  |
|-----------            |                                                                                                         |
|OVERALL (a)            |        1/70 (1%)          2/50 (4%)          5/69 (7%)          2/70 (3%)          0/40 (0%)            |
|ADJUSTED (b)           |         3.8%               7.7%              18.9%              10.5%               0.0%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 2 (c)|        0/10 (0%)          0/0                0/0                0/10 (0%)          0/24 (0%)            |
|TERMINAL (d)           |        1/26 (4%)          1/24 (4%)          2/21 (10%)         0/10 (0%)          0/0                  |
|FIRST INCIDENCE (DAYS) |         729 (T)            700                693                674                ---                 |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P=0.171            P=0.469            P=0.079            P=0.278              (e)                |
|INCIDENTAL TUMOR       |        P=0.330            P=0.472            P=0.133            P=0.411              (e)                |
|LOGISTIC REGRESSION    |        P=0.445            P=0.465            P=0.099            P=0.357              (e)                |
|COCHRAN-ARMITAGE       |        P=0.290N                                                                                         |
|FISHER EXACT           |                           P=0.375            P=0.101            P=0.500            P=0.636N             |
|=================================================================================================================================|
         DATE: 05/19/95                     EXPERIMENT: 05061 TEST: 01                                                 PAGE  20
                   STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE RATS(FISCHER344) -- 1-AMINO 2,4-DIBROMOANTHRAQUINONE
                       TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE                   |         UNTREATE           0.2%               0.5%               1.0%               2.0%                |
|                       |         D 71 UM            71LM               71MLM              71MHM              MALE                |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Squamous Cell Papilloma, Papilloma, Squamous Cell Carcinoma or Keratoacanthoma                                              |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |          #                  #                  #                  #                  #                  |
|-----------            |                                                                                                         |
|OVERALL (a)            |        2/70 (3%)          3/50 (6%)          5/69 (7%)          3/70 (4%)          0/40 (0%)            |
|ADJUSTED (b)           |         6.9%              10.1%              18.9%              12.6%               0.0%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 2 (c)|        0/10 (0%)          0/0                0/0                0/10 (0%)          0/24 (0%)            |
|TERMINAL (d)           |        1/26 (4%)          1/24 (4%)          2/21 (10%)         0/10 (0%)          0/0                  |
|FIRST INCIDENCE (DAYS) |         692                629                693                527                ---                 |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P=0.196            P=0.463            P=0.177            P=0.274              (e)                |
|INCIDENTAL TUMOR       |        P=0.607            P=0.422            P=0.291            P=0.489              (e)                |
|LOGISTIC REGRESSION    |        P=0.494            P=0.426            P=0.224            P=0.399            P=1.000N             |
|COCHRAN-ARMITAGE       |        P=0.206N                                                                                         |
|FISHER EXACT           |                           P=0.344            P=0.215            P=0.500            P=0.403N             |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Squamous Cell Papilloma, Papilloma, or Keratoacanthoma                                                                      |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |          #                  #                  #                  #                  #                  |
|-----------            |                                                                                                         |
|OVERALL (a)            |        2/70 (3%)          3/50 (6%)          5/69 (7%)          3/70 (4%)          0/40 (0%)            |
|ADJUSTED (b)           |         6.9%              10.1%              18.9%              12.6%               0.0%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 2 (c)|        0/10 (0%)          0/0                0/0                0/10 (0%)          0/24 (0%)            |
|TERMINAL (d)           |        1/26 (4%)          1/24 (4%)          2/21 (10%)         0/10 (0%)          0/0                  |
|FIRST INCIDENCE (DAYS) |         692                629                693                527                ---                 |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P=0.196            P=0.463            P=0.177            P=0.274              (e)                |
|INCIDENTAL TUMOR       |        P=0.607            P=0.422            P=0.291            P=0.489              (e)                |
|LOGISTIC REGRESSION    |        P=0.494            P=0.426            P=0.224            P=0.399            P=1.000N             |
|COCHRAN-ARMITAGE       |        P=0.206N                                                                                         |
|FISHER EXACT           |                           P=0.344            P=0.215            P=0.500            P=0.403N             |
|=================================================================================================================================|
         DATE: 05/19/95                     EXPERIMENT: 05061 TEST: 01                                                 PAGE  21
                   STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE RATS(FISCHER344) -- 1-AMINO 2,4-DIBROMOANTHRAQUINONE
                       TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE                   |         UNTREATE           0.2%               0.5%               1.0%               2.0%                |
|                       |         D 71 UM            71LM               71MLM              71MHM              MALE                |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach                                                                                                             |
|     Squamous Cell Carcinoma or Papilloma Squamous                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |          #                  #                  #                  #                  #                  |
|-----------            |                                                                                                         |
|OVERALL (a)            |        0/70 (0%)          2/50 (4%)          0/69 (0%)          2/70 (3%)          1/40 (3%)            |
|ADJUSTED (b)           |         0.0%               7.7%               0.0%              15.0%               4.2%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 2 (c)|        0/10 (0%)          0/0                0/0                0/10 (0%)          1/24 (4%)            |
|TERMINAL (d)           |        0/26 (0%)          1/24 (4%)          0/21 (0%)          1/10 (10%)         0/0                  |
|FIRST INCIDENCE (DAYS) |         ---                700                ---                702                456 (I)             |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P=0.123            P=0.220              (e)              P=0.099            P=0.674              |
|INCIDENTAL TUMOR       |        P=0.159            P=0.222              (e)              P=0.147            P=0.674              |
|LOGISTIC REGRESSION    |        P=0.067            P=0.213              (e)              P=0.129            P=0.460              |
|COCHRAN-ARMITAGE       |        P=0.324                                                                                          |
|FISHER EXACT           |                           P=0.172              (e)              P=0.248            P=0.364              |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach                                                                                                             |
|     Squamous Cell Papilloma                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |          #                  #                  #                  #                  #                  |
|-----------            |                                                                                                         |
|OVERALL (a)            |        0/70 (0%)          2/50 (4%)          0/69 (0%)          1/70 (1%)          1/40 (3%)            |
|ADJUSTED (b)           |         0.0%               7.7%               0.0%               5.6%               4.2%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 2 (c)|        0/10 (0%)          0/0                0/0                0/10 (0%)          1/24 (4%)            |
|TERMINAL (d)           |        0/26 (0%)          1/24 (4%)          0/21 (0%)          0/10 (0%)          0/0                  |
|FIRST INCIDENCE (DAYS) |         ---                700                ---                702                456 (I)             |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P=0.296            P=0.220              (e)              P=0.398            P=0.674              |
|INCIDENTAL TUMOR       |        P=0.356            P=0.222              (e)              P=0.515            P=0.674              |
|LOGISTIC REGRESSION    |        P=0.189            P=0.213              (e)              P=0.420            P=0.460              |
|COCHRAN-ARMITAGE       |        P=0.407                                                                                          |
|FISHER EXACT           |                           P=0.172              (e)              P=0.500            P=0.364              |
|=================================================================================================================================|
         DATE: 05/19/95                     EXPERIMENT: 05061 TEST: 01                                                 PAGE  22
                   STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE RATS(FISCHER344) -- 1-AMINO 2,4-DIBROMOANTHRAQUINONE
                       TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE                   |         UNTREATE           0.2%               0.5%               1.0%               2.0%                |
|                       |         D 71 UM            71LM               71MLM              71MHM              MALE                |
|=================================================================================================================================|
|                                                                                                                                 |
|Testes                                                                                                                           |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                                                                         |
|-----------            |                                                                                                         |
|OVERALL (a)            |       46/70 (66%)        37/50 (74%)        55/69 (80%)        47/68 (69%)         7/40 (18%)           |
|ADJUSTED (b)           |        97.8%             100.0%             100.0%             100.0%              28.0%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 2 (c)|        3/10 (30%)         0/0                0/0                5/8 (63%)          6/24 (25%)           |
|TERMINAL (d)           |       25/26 (96%)        24/24 (100%)       21/21 (100%)       10/10 (100%)        0/0                  |
|FIRST INCIDENCE (DAYS) |         421                604                521                456 (I)            447                 |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P<0.001 **         P=0.410N           P=0.021 *          P<0.001 **         P=0.637              |
|INCIDENTAL TUMOR       |        P=0.496N           P=0.600N           P=0.115            P=0.020 *          P=0.484N             |
|LOGISTIC REGRESSION    |        P=0.372            P=0.404N           P=0.286            P=0.162            P=0.634N             |
|COCHRAN-ARMITAGE       |        P<0.001N**                                                                                       |
|FISHER EXACT           |                           P=0.222            P=0.048 *          P=0.404            P<0.001N**           |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: C-Cell                                                                                                            |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                                                                         |
|-----------            |                                                                                                         |
|OVERALL (a)            |       10/69 (14%)         5/50 (10%)         3/69 (4%)          3/61 (5%)          0/40 (0%)            |
|ADJUSTED (b)           |        27.8%              20.8%              11.6%              23.5%               0.0%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 2 (c)|        1/10 (10%)         0/0                0/0                0/1 (0%)           0/24 (0%)            |
|TERMINAL (d)           |        4/25 (16%)         5/24 (21%)         1/21 (5%)          2/10 (20%)         0/0                  |
|FIRST INCIDENCE (DAYS) |         427                729 (T)            702                671                ---                 |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P=0.088N           P=0.251N           P=0.092N           P=0.329N           P=0.212N             |
|INCIDENTAL TUMOR       |        P=0.020N*          P=0.414N           P=0.037N*          P=0.144N           P=0.039N*            |
|LOGISTIC REGRESSION    |        P=0.029N*          P=0.243N           P=0.029N*          P=0.085N           P=0.094N             |
|COCHRAN-ARMITAGE       |        P=0.004N**                                                                                       |
|FISHER EXACT           |                           P=0.331N           P=0.039N*          P=0.062N           P=0.008N**           |
|=================================================================================================================================|
         DATE: 05/19/95                     EXPERIMENT: 05061 TEST: 01                                                 PAGE  23
                   STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE RATS(FISCHER344) -- 1-AMINO 2,4-DIBROMOANTHRAQUINONE
                       TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE                   |         UNTREATE           0.2%               0.5%               1.0%               2.0%                |
|                       |         D 71 UM            71LM               71MLM              71MHM              MALE                |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: C-Cell                                                                                                            |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                                                                         |
|-----------            |                                                                                                         |
|OVERALL (a)            |       10/69 (14%)         5/50 (10%)         3/69 (4%)          3/61 (5%)          0/40 (0%)            |
|ADJUSTED (b)           |        27.8%              20.8%              11.6%              23.5%               0.0%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 2 (c)|        1/10 (10%)         0/0                0/0                0/1 (0%)           0/24 (0%)            |
|TERMINAL (d)           |        4/25 (16%)         5/24 (21%)         1/21 (5%)          2/10 (20%)         0/0                  |
|FIRST INCIDENCE (DAYS) |         427                729 (T)            702                671                ---                 |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P=0.088N           P=0.251N           P=0.092N           P=0.329N           P=0.212N             |
|INCIDENTAL TUMOR       |        P=0.020N*          P=0.414N           P=0.037N*          P=0.144N           P=0.039N*            |
|LOGISTIC REGRESSION    |        P=0.029N*          P=0.243N           P=0.029N*          P=0.085N           P=0.094N             |
|COCHRAN-ARMITAGE       |        P=0.004N**                                                                                       |
|FISHER EXACT           |                           P=0.331N           P=0.039N*          P=0.062N           P=0.008N**           |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: Follicular Cell                                                                                                   |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                                                                         |
|-----------            |                                                                                                         |
|OVERALL (a)            |        0/69 (0%)          0/50 (0%)          2/69 (3%)          1/61 (2%)          1/40 (3%)            |
|ADJUSTED (b)           |         0.0%               0.0%               6.9%              10.0%               2.5%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          1/10 (10%)           |
|INTERIM SACRIFICE 2 (c)|        0/10 (0%)          0/0                0/0                0/1 (0%)           0/24 (0%)            |
|TERMINAL (d)           |        0/25 (0%)          0/24 (0%)          1/21 (5%)          1/10 (10%)         0/0                  |
|FIRST INCIDENCE (DAYS) |         ---                ---                636                729 (T)            273 (I)             |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P=0.027 *            (e)              P=0.236            P=0.318            P=0.500              |
|INCIDENTAL TUMOR       |        P=0.048 *            (e)              P=0.284            P=0.318            P=0.500              |
|LOGISTIC REGRESSION    |        P=0.174              (e)              P=0.258            P=0.318            P=0.500              |
|COCHRAN-ARMITAGE       |        P=0.234                                                                                          |
|FISHER EXACT           |                             (e)              P=0.248            P=0.469            P=0.367              |
|=================================================================================================================================|
         DATE: 05/19/95                     EXPERIMENT: 05061 TEST: 01                                                 PAGE  24
                   STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE RATS(FISCHER344) -- 1-AMINO 2,4-DIBROMOANTHRAQUINONE
                       TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE                   |         UNTREATE           0.2%               0.5%               1.0%               2.0%                |
|                       |         D 71 UM            71LM               71MLM              71MHM              MALE                |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: Follicular Cell                                                                                                   |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                                                                         |
|-----------            |                                                                                                         |
|OVERALL (a)            |        2/69 (3%)          3/50 (6%)          1/69 (1%)          3/61 (5%)          0/40 (0%)            |
|ADJUSTED (b)           |         8.0%              12.5%               2.1%              18.7%               0.0%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 2 (c)|        0/10 (0%)          0/0                0/0                0/1 (0%)           0/24 (0%)            |
|TERMINAL (d)           |        2/25 (8%)          3/24 (13%)         0/21 (0%)          1/10 (10%)         0/0                  |
|FIRST INCIDENCE (DAYS) |         729 (T)            729 (T)            623                577                ---                 |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P=0.281            P=0.481            P=0.519N           P=0.205              (e)                |
|INCIDENTAL TUMOR       |        P=0.464            P=0.481            P=0.470N           P=0.337              (e)                |
|LOGISTIC REGRESSION    |        P=0.532            P=0.481            P=0.466N           P=0.346              (e)                |
|COCHRAN-ARMITAGE       |        P=0.269N                                                                                         |
|FISHER EXACT           |                           P=0.350            P=0.500N           P=0.442            P=0.399N             |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: Follicular Cell                                                                                                   |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                                                                         |
|-----------            |                                                                                                         |
|OVERALL (a)            |        2/69 (3%)          3/50 (6%)          3/69 (4%)          4/61 (7%)          1/40 (3%)            |
|ADJUSTED (b)           |         8.0%              12.5%               8.8%              27.7%               2.5%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          1/10 (10%)           |
|INTERIM SACRIFICE 2 (c)|        0/10 (0%)          0/0                0/0                0/1 (0%)           0/24 (0%)            |
|TERMINAL (d)           |        2/25 (8%)          3/24 (13%)         1/21 (5%)          2/10 (20%)         0/0                  |
|FIRST INCIDENCE (DAYS) |         729 (T)            729 (T)            623                577                273 (I)             |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P=0.016 *          P=0.481            P=0.482            P=0.079            P=0.500              |
|INCIDENTAL TUMOR       |        P=0.056            P=0.481            P=0.563            P=0.149            P=0.500              |
|LOGISTIC REGRESSION    |        P=0.195            P=0.481            P=0.544            P=0.181            P=0.699              |
|COCHRAN-ARMITAGE       |        P=0.545N                                                                                         |
|FISHER EXACT           |                           P=0.350            P=0.500            P=0.283            P=0.697N             |
|=================================================================================================================================|
         DATE: 05/19/95                     EXPERIMENT: 05061 TEST: 01                                                 PAGE  25
                   STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE RATS(FISCHER344) -- 1-AMINO 2,4-DIBROMOANTHRAQUINONE
                       TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE                   |         UNTREATE           0.2%               0.5%               1.0%               2.0%                |
|                       |         D 71 UM            71LM               71MLM              71MHM              MALE                |
|=================================================================================================================================|
|                                                                                                                                 |
|Tissue NOS                                                                                                                       |
|     Sarcoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |          #                  #                  #                  #                  #                  |
|-----------            |                                                                                                         |
|OVERALL (a)            |        0/70 (0%)          0/50 (0%)          0/69 (0%)          0/70 (0%)          0/40 (0%)            |
|ADJUSTED (b)           |         0.0%               0.0%               0.0%               0.0%               0.0%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 2 (c)|        0/10 (0%)          0/0                0/0                0/10 (0%)          0/24 (0%)            |
|TERMINAL (d)           |        0/26 (0%)          0/24 (0%)          0/21 (0%)          0/10 (0%)          0/0                  |
|FIRST INCIDENCE (DAYS) |         ---                ---                ---                ---                ---                 |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |          (e)                (e)                (e)                (e)                (e)                |
|INCIDENTAL TUMOR       |          (e)                (e)                (e)                (e)                (e)                |
|LOGISTIC REGRESSION    |          (e)                (e)                (e)                (e)                (e)                |
|COCHRAN-ARMITAGE       |          (e)                                                                                            |
|FISHER EXACT           |                             (e)                (e)                (e)                (e)                |
|=================================================================================================================================|
|                                                                                                                                 |
|Urinary Bladder                                                                                                                  |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                                                                         |
|-----------            |                                                                                                         |
|OVERALL (a)            |        0/70 (0%)          0/48 (0%)          1/67 (1%)          4/70 (6%)          1/38 (3%)            |
|ADJUSTED (b)           |         0.0%               0.0%               4.3%              24.5%               4.2%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/9 (0%)           0/10 (0%)          0/9 (0%)             |
|INTERIM SACRIFICE 2 (c)|        0/10 (0%)          0/0                0/0                0/10 (0%)          1/24 (4%)            |
|TERMINAL (d)           |        0/26 (0%)          0/22 (0%)          0/21 (0%)          1/10 (10%)         0/0                  |
|FIRST INCIDENCE (DAYS) |         ---                ---                720                674                456 (I)             |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P=0.004 **           (e)              P=0.454            P=0.012 *          P=0.674              |
|INCIDENTAL TUMOR       |        P=0.011 *            (e)              P=0.586            P=0.039 *          P=0.674              |
|LOGISTIC REGRESSION    |        P=0.002 **           (e)              P=0.491            P=0.021 *          P=0.451              |
|COCHRAN-ARMITAGE       |        P=0.084                                                                                          |
|FISHER EXACT           |                             (e)              P=0.489            P=0.060            P=0.352              |
|=================================================================================================================================|
         DATE: 05/19/95                     EXPERIMENT: 05061 TEST: 01                                                 PAGE  26
                   STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE RATS(FISCHER344) -- 1-AMINO 2,4-DIBROMOANTHRAQUINONE
                       TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE                   |         UNTREATE           0.2%               0.5%               1.0%               2.0%                |
|                       |         D 71 UM            71LM               71MLM              71MHM              MALE                |
|=================================================================================================================================|
|                                                                                                                                 |
|Urinary Bladder                                                                                                                  |
|     Papilloma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                                                                         |
|-----------            |                                                                                                         |
|OVERALL (a)            |        0/70 (0%)          1/48 (2%)          2/67 (3%)          8/70 (11%)         4/38 (11%)           |
|ADJUSTED (b)           |         0.0%               3.7%               9.5%              40.3%              14.7%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/9 (0%)           0/10 (0%)          1/9 (11%)            |
|INTERIM SACRIFICE 2 (c)|        0/10 (0%)          0/0                0/0                0/10 (0%)          3/24 (13%)           |
|TERMINAL (d)           |        0/26 (0%)          0/22 (0%)          2/21 (10%)         2/10 (20%)         0/0                  |
|FIRST INCIDENCE (DAYS) |         ---                700                729 (T)            493                273 (I)             |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P<0.001 **         P=0.479            P=0.192            P<0.001 **         P=0.160              |
|INCIDENTAL TUMOR       |        P<0.001 **         P=0.484            P=0.192            P=0.004 **         P=0.160              |
|LOGISTIC REGRESSION    |        P<0.001 **         P=0.459            P=0.192            P=0.002 **         P=0.051              |
|COCHRAN-ARMITAGE       |        P=0.002 **                                                                                       |
|FISHER EXACT           |                           P=0.407            P=0.237            P=0.003 **         P=0.014 *            |
|=================================================================================================================================|
|                                                                                                                                 |
|Urinary Bladder                                                                                                                  |
|     Squamous Cell Carcinoma                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                                                                         |
|-----------            |                                                                                                         |
|OVERALL (a)            |        0/70 (0%)          0/48 (0%)          0/67 (0%)          0/70 (0%)          1/38 (3%)            |
|ADJUSTED (b)           |         0.0%               0.0%               0.0%               0.0%               4.2%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/9 (0%)           0/10 (0%)          0/9 (0%)             |
|INTERIM SACRIFICE 2 (c)|        0/10 (0%)          0/0                0/0                0/10 (0%)          1/24 (4%)            |
|TERMINAL (d)           |        0/26 (0%)          0/22 (0%)          0/21 (0%)          0/10 (0%)          0/0                  |
|FIRST INCIDENCE (DAYS) |         ---                ---                ---                ---                456 (I)             |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P=0.412              (e)                (e)                (e)              P=0.674              |
|INCIDENTAL TUMOR       |        P=0.412              (e)                (e)                (e)              P=0.674              |
|LOGISTIC REGRESSION    |        P=0.144              (e)                (e)                (e)              P=0.451              |
|COCHRAN-ARMITAGE       |        P=0.089                                                                                          |
|FISHER EXACT           |                             (e)                (e)                (e)              P=0.352              |
|=================================================================================================================================|
         DATE: 05/19/95                     EXPERIMENT: 05061 TEST: 01                                                 PAGE  27
                   STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE RATS(FISCHER344) -- 1-AMINO 2,4-DIBROMOANTHRAQUINONE
                       TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE                   |         UNTREATE           0.2%               0.5%               1.0%               2.0%                |
|                       |         D 71 UM            71LM               71MLM              71MHM              MALE                |
|=================================================================================================================================|
|                                                                                                                                 |
|Urinary Bladder                                                                                                                  |
|     Squamous Cell Papilloma                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                                                                         |
|-----------            |                                                                                                         |
|OVERALL (a)            |        0/70 (0%)          0/48 (0%)          0/67 (0%)          0/70 (0%)          0/38 (0%)            |
|ADJUSTED (b)           |         0.0%               0.0%               0.0%               0.0%               0.0%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/9 (0%)           0/10 (0%)          0/9 (0%)             |
|INTERIM SACRIFICE 2 (c)|        0/10 (0%)          0/0                0/0                0/10 (0%)          0/24 (0%)            |
|TERMINAL (d)           |        0/26 (0%)          0/22 (0%)          0/21 (0%)          0/10 (0%)          0/0                  |
|FIRST INCIDENCE (DAYS) |         ---                ---                ---                ---                ---                 |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |          (e)                (e)                (e)                (e)                (e)                |
|INCIDENTAL TUMOR       |          (e)                (e)                (e)                (e)                (e)                |
|LOGISTIC REGRESSION    |          (e)                (e)                (e)                (e)                (e)                |
|COCHRAN-ARMITAGE       |          (e)                                                                                            |
|FISHER EXACT           |                             (e)                (e)                (e)                (e)                |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Polyp Stromal                                                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                                                                         |
|-----------            |                                                                                                         |
|OVERALL (a)            |                                                                                                         |
|ADJUSTED (b)           |                                                                                                         |
|INTERIM SACRIFICE 1 (c)|                                                                                                         |
|INTERIM SACRIFICE 2 (c)|                                                                                                         |
|TERMINAL (d)           |                                                                                                         |
|FIRST INCIDENCE (DAYS) |                                                                                                         |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |                                                                                                         |
|INCIDENTAL TUMOR       |                                                                                                         |
|LOGISTIC REGRESSION    |                                                                                                         |
|COCHRAN-ARMITAGE       |                                                                                                         |
|=================================================================================================================================|
         DATE: 05/19/95                     EXPERIMENT: 05061 TEST: 01                                                 PAGE  28
                   STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE RATS(FISCHER344) -- 1-AMINO 2,4-DIBROMOANTHRAQUINONE
                       TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE                   |         UNTREATE           0.2%               0.5%               1.0%               2.0%                |
|                       |         D 71 UM            71LM               71MLM              71MHM              MALE                |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Sarcoma Stromal or Polyp Stromal                                                                                            |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                                                                         |
|-----------            |                                                                                                         |
|OVERALL (a)            |                                                                                                         |
|ADJUSTED (b)           |                                                                                                         |
|INTERIM SACRIFICE 1 (c)|                                                                                                         |
|INTERIM SACRIFICE 2 (c)|                                                                                                         |
|TERMINAL (d)           |                                                                                                         |
|FIRST INCIDENCE (DAYS) |                                                                                                         |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |                                                                                                         |
|INCIDENTAL TUMOR       |                                                                                                         |
|LOGISTIC REGRESSION    |                                                                                                         |
|COCHRAN-ARMITAGE       |                                                                                                         |
|=================================================================================================================================|
|                                                                                                                                 |
|Zymbal's Gland                                                                                                                   |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |          #                  #                  #                  #                  #                  |
|-----------            |                                                                                                         |
|OVERALL (a)            |        1/70 (1%)          1/50 (2%)          0/69 (0%)          1/70 (1%)          0/40 (0%)            |
|ADJUSTED (b)           |         3.8%               2.6%               0.0%               1.8%               0.0%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 2 (c)|        0/10 (0%)          0/0                0/0                0/10 (0%)          0/24 (0%)            |
|TERMINAL (d)           |        1/26 (4%)          0/24 (0%)          0/21 (0%)          0/10 (0%)          0/0                  |
|FIRST INCIDENCE (DAYS) |         729 (T)            629                ---                435                ---                 |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P=0.699N           P=0.746            P=0.543N           P=0.658              (e)                |
|INCIDENTAL TUMOR       |        P=0.412N           P=0.690            P=0.543N           P=0.736              (e)                |
|LOGISTIC REGRESSION    |        P=0.456N           P=0.718            P=0.543N           P=0.758              (e)                |
|COCHRAN-ARMITAGE       |        P=0.410N                                                                                         |
|FISHER EXACT           |                           P=0.662            P=0.504N           P=0.752N           P=0.636N             |
|=================================================================================================================================|
         DATE: 05/19/95                     EXPERIMENT: 05061 TEST: 01                                                 PAGE  29
                   STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE RATS(FISCHER344) -- 1-AMINO 2,4-DIBROMOANTHRAQUINONE
                       TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE                   |         UNTREATE           0.2%               0.5%               1.0%               2.0%                |
|                       |         D 71 UM            71LM               71MLM              71MHM              MALE                |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Leukemia: Lymphocytic, Monocytic, Mononuclear, or Undifferentiated                                                          |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |          #                  #                  #                  #                  #                  |
|-----------            |                                                                                                         |
|OVERALL (a)            |       25/70 (36%)         5/50 (10%)         3/69 (4%)          3/70 (4%)          0/40 (0%)            |
|ADJUSTED (b)           |        59.0%              18.8%              11.7%               6.5%               0.0%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 2 (c)|        0/10 (0%)          0/0                0/0                2/10 (20%)         0/24 (0%)            |
|TERMINAL (d)           |        9/26 (35%)         4/24 (17%)         2/21 (10%)         0/10 (0%)          0/0                  |
|FIRST INCIDENCE (DAYS) |         514                604                650                456 (I)            ---                 |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P<0.001N**         P<0.001N**         P<0.001N**         P=0.003N**           (e)                |
|INCIDENTAL TUMOR       |        P<0.001N**         P<0.001N**         P<0.001N**         P<0.001N**         P=0.419N             |
|LOGISTIC REGRESSION    |        P<0.001N**         P<0.001N**         P<0.001N**         P<0.001N**         P=0.084N             |
|COCHRAN-ARMITAGE       |        P<0.001N**                                                                                       |
|FISHER EXACT           |                           P<0.001N**         P<0.001N**         P<0.001N**         P<0.001N**           |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Mesothelioma: Benign, Malignant, NOS                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |          #                  #                  #                  #                  #                  |
|-----------            |                                                                                                         |
|OVERALL (a)            |        1/70 (1%)          1/50 (2%)          1/69 (1%)          2/70 (3%)          1/40 (3%)            |
|ADJUSTED (b)           |         3.8%               4.2%               3.6%               3.6%               3.3%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 2 (c)|        0/10 (0%)          0/0                0/0                1/10 (10%)         0/24 (0%)            |
|TERMINAL (d)           |        1/26 (4%)          1/24 (4%)          0/21 (0%)          0/10 (0%)          0/0                  |
|FIRST INCIDENCE (DAYS) |         729 (T)            729 (T)            702                436                400                 |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P=0.311            P=0.745            P=0.729            P=0.393            P=0.362              |
|INCIDENTAL TUMOR       |        P=0.554            P=0.745            P=0.734N           P=0.459            P=0.581              |
|LOGISTIC REGRESSION    |        P=0.392            P=0.745            P=0.763N           P=0.513            P=0.566              |
|COCHRAN-ARMITAGE       |        P=0.424                                                                                          |
|FISHER EXACT           |                           P=0.662            P=0.748            P=0.500            P=0.597              |
|=================================================================================================================================|
         DATE: 05/19/95                     EXPERIMENT: 05061 TEST: 01                                                 PAGE  30
                   STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE RATS(FISCHER344) -- 1-AMINO 2,4-DIBROMOANTHRAQUINONE
                       TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE                   |         UNTREATE           0.2%               0.5%               1.0%               2.0%                |
|                       |         D 71 UM            71LM               71MLM              71MHM              MALE                |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Benign Tumors                                                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |          #                  #                  #                  #                  #                  |
|-----------            |                                                                                                         |
|OVERALL (a)            |       57/70 (81%)        40/50 (80%)        60/69 (87%)        57/70 (81%)        30/40 (75%)           |
|ADJUSTED (b)           |       100.0%             100.0%             100.0%             100.0%              90.6%                |
|INTERIM SACRIFICE 1 (c)|        1/10 (10%)         0/10 (0%)          2/10 (20%)         0/10 (0%)          5/10 (50%)           |
|INTERIM SACRIFICE 2 (c)|        7/10 (70%)         0/0                0/0               10/10 (100%)       21/24 (88%)           |
|TERMINAL (d)           |       26/26 (100%)       24/24 (100%)       21/21 (100%)       10/10 (100%)        0/0                  |
|FIRST INCIDENCE (DAYS) |         273 (I)            604                273 (I)            352                273 (I)             |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P<0.001 **         P=0.225N           P=0.059            P<0.001 **         P=0.005 **           |
|INCIDENTAL TUMOR       |        P=0.024 *          P=0.500N           P=0.500            P=0.252            P=0.062              |
|LOGISTIC REGRESSION    |        P=0.023N*          P=0.586N           P=0.427N           P=0.308N           P=0.027N*            |
|COCHRAN-ARMITAGE       |        P=0.226N                                                                                         |
|FISHER EXACT           |                           P=0.512N           P=0.255            P=0.586N           P=0.287N             |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant Tumors                                                                                                            |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |          #                  #                  #                  #                  #                  |
|-----------            |                                                                                                         |
|OVERALL (a)            |       29/70 (41%)        24/50 (48%)        57/69 (83%)        55/70 (79%)        29/40 (73%)           |
|ADJUSTED (b)           |        67.0%              71.7%             100.0%             100.0%              90.5%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          2/10 (20%)           |
|INTERIM SACRIFICE 2 (c)|        0/10 (0%)          0/0                0/0                8/10 (80%)        21/24 (88%)           |
|TERMINAL (d)           |       12/26 (46%)        15/24 (63%)        21/21 (100%)       10/10 (100%)        0/0                  |
|FIRST INCIDENCE (DAYS) |         514                604                465                435                273 (I)             |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P<0.001 **         P=0.398N           P<0.001 **         P<0.001 **         P<0.001 **           |
|INCIDENTAL TUMOR       |        P<0.001 **         P=0.562N           P<0.001 **         P<0.001 **         P<0.001 **           |
|LOGISTIC REGRESSION    |        P<0.001 **         P=0.447N           P<0.001 **         P<0.001 **         P=0.013 *            |
|COCHRAN-ARMITAGE       |        P<0.001 **                                                                                       |
|FISHER EXACT           |                           P=0.298            P<0.001 **         P<0.001 **         P=0.001 **           |
|=================================================================================================================================|
         DATE: 05/19/95                     EXPERIMENT: 05061 TEST: 01                                                 PAGE  31
                   STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE RATS(FISCHER344) -- 1-AMINO 2,4-DIBROMOANTHRAQUINONE
                       TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE                   |         UNTREATE           0.2%               0.5%               1.0%               2.0%                |
|                       |         D 71 UM            71LM               71MLM              71MHM              MALE                |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant and Benign Tumors                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |          #                  #                  #                  #                  #                  |
|-----------            |                                                                                                         |
|OVERALL (a)            |       57/70 (81%)        40/50 (80%)        61/69 (88%)        58/70 (83%)        36/40 (90%)           |
|ADJUSTED (b)           |       100.0%             100.0%             100.0%             100.0%             100.0%                |
|INTERIM SACRIFICE 1 (c)|        1/10 (10%)         0/10 (0%)          2/10 (20%)         0/10 (0%)          6/10 (60%)           |
|INTERIM SACRIFICE 2 (c)|        7/10 (70%)         0/0                0/0               10/10 (100%)       24/24 (100%)          |
|TERMINAL (d)           |       26/26 (100%)       24/24 (100%)       21/21 (100%)       10/10 (100%)        0/0                  |
|FIRST INCIDENCE (DAYS) |         273 (I)            604                273 (I)            352                273 (I)             |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P<0.001 **         P=0.225N           P=0.048 *          P<0.001 **         P<0.001 **           |
|INCIDENTAL TUMOR       |        P<0.001 **         P=0.500N           P=0.301            P=0.145            P<0.001 **           |
|LOGISTIC REGRESSION    |        P=0.041N*          P=0.586N           P=0.681            P=0.431N           P=0.066N             |
|COCHRAN-ARMITAGE       |        P=0.156                                                                                          |
|FISHER EXACT           |                           P=0.512N           P=0.181            P=0.500            P=0.179              |
|=================================================================================================================================|
         DATE: 05/19/95                     EXPERIMENT: 05061 TEST: 01                                                 PAGE  32
                  STATISTICAL ANALYSIS OF PRIMARY TUMORS IN FEMALE RATS(FISCHER344) -- 1-AMINO 2,4-DIBROMOANTHRAQUINONE
                       TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE                   |         UNTREATE           0.2%               0.5%               1.0%               2.0%                |
|                       |         D 71UF             71LF               71MLF              71MHF              FEMALE              |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                                                                         |
|-----------            |                                                                                                         |
|OVERALL (a)            |        2/67 (3%)          1/50 (2%)          0/69 (0%)          0/58 (0%)          0/37 (0%)            |
|ADJUSTED (b)           |         5.2%               3.1%               0.0%               0.0%               0.0%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 2 (c)|        0/10 (0%)          0/0                0/0                0/1 (0%)           0/20 (0%)            |
|TERMINAL (d)           |        1/35 (3%)          1/32 (3%)          0/37 (0%)          0/11 (0%)          0/0                  |
|FIRST INCIDENCE (DAYS) |         708                729 (T)            ---                ---                ---                 |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P=0.311N           P=0.549N           P=0.228N           P=0.479N             (e)                |
|INCIDENTAL TUMOR       |        P=0.190N           P=0.559N           P=0.154N           P=0.244N             (e)                |
|LOGISTIC REGRESSION    |        P=0.246N           P=0.554N           P=0.204N           P=0.373N             (e)                |
|COCHRAN-ARMITAGE       |        P=0.141N                                                                                         |
|FISHER EXACT           |                           P=0.609N           P=0.241N           P=0.285N           P=0.413N             |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Pheochromocytoma Benign                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                                                                         |
|-----------            |                                                                                                         |
|OVERALL (a)            |        2/67 (3%)          3/50 (6%)          1/69 (1%)          3/58 (5%)          0/37 (0%)            |
|ADJUSTED (b)           |         5.7%               9.4%               2.7%               9.6%               0.0%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 2 (c)|        0/10 (0%)          0/0                0/0                1/1 (100%)         0/20 (0%)            |
|TERMINAL (d)           |        2/35 (6%)          3/32 (9%)          1/37 (3%)          0/11 (0%)          0/0                  |
|FIRST INCIDENCE (DAYS) |         729 (T)            729 (T)            729 (T)            462 (I)            ---                 |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P=0.607            P=0.459            P=0.481N           P=0.106              (e)                |
|INCIDENTAL TUMOR       |        P=0.554N           P=0.459            P=0.481N           P=0.311              (e)                |
|LOGISTIC REGRESSION    |        P=0.692N           P=0.459            P=0.481N           P=0.560              (e)                |
|COCHRAN-ARMITAGE       |        P=0.288N                                                                                         |
|FISHER EXACT           |                           P=0.363            P=0.489N           P=0.432            P=0.413N             |
|=================================================================================================================================|
         DATE: 05/19/95                     EXPERIMENT: 05061 TEST: 01                                                 PAGE  33
                  STATISTICAL ANALYSIS OF PRIMARY TUMORS IN FEMALE RATS(FISCHER344) -- 1-AMINO 2,4-DIBROMOANTHRAQUINONE
                       TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE                   |         UNTREATE           0.2%               0.5%               1.0%               2.0%                |
|                       |         D 71UF             71LF               71MLF              71MHF              FEMALE              |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Pheochromocytoma Malignant                                                                                                  |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                                                                         |
|-----------            |                                                                                                         |
|OVERALL (a)            |        0/67 (0%)          0/50 (0%)          0/69 (0%)          0/58 (0%)          0/37 (0%)            |
|ADJUSTED (b)           |         0.0%               0.0%               0.0%               0.0%               0.0%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 2 (c)|        0/10 (0%)          0/0                0/0                0/1 (0%)           0/20 (0%)            |
|TERMINAL (d)           |        0/35 (0%)          0/32 (0%)          0/37 (0%)          0/11 (0%)          0/0                  |
|FIRST INCIDENCE (DAYS) |         ---                ---                ---                ---                ---                 |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |          (e)                (e)                (e)                (e)                (e)                |
|INCIDENTAL TUMOR       |          (e)                (e)                (e)                (e)                (e)                |
|LOGISTIC REGRESSION    |          (e)                (e)                (e)                (e)                (e)                |
|COCHRAN-ARMITAGE       |          (e)                                                                                            |
|FISHER EXACT           |                             (e)                (e)                (e)                (e)                |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Pheochromocytoma: Benign, Complex, Malignant, NOS                                                                           |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                                                                         |
|-----------            |                                                                                                         |
|OVERALL (a)            |        2/67 (3%)          3/50 (6%)          2/69 (3%)          3/58 (5%)          0/37 (0%)            |
|ADJUSTED (b)           |         5.7%               9.4%               4.6%               9.6%               0.0%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 2 (c)|        0/10 (0%)          0/0                0/0                1/1 (100%)         0/20 (0%)            |
|TERMINAL (d)           |        2/35 (6%)          3/32 (9%)          1/37 (3%)          0/11 (0%)          0/0                  |
|FIRST INCIDENCE (DAYS) |         729 (T)            729 (T)            660                462 (I)            ---                 |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P=0.568            P=0.459            P=0.665N           P=0.106              (e)                |
|INCIDENTAL TUMOR       |        P=0.532N           P=0.459            P=0.612N           P=0.311              (e)                |
|LOGISTIC REGRESSION    |        P=0.660N           P=0.459            P=0.638N           P=0.560              (e)                |
|COCHRAN-ARMITAGE       |        P=0.276N                                                                                         |
|FISHER EXACT           |                           P=0.363            P=0.679N           P=0.432            P=0.413N             |
|=================================================================================================================================|
         DATE: 05/19/95                     EXPERIMENT: 05061 TEST: 01                                                 PAGE  34
                  STATISTICAL ANALYSIS OF PRIMARY TUMORS IN FEMALE RATS(FISCHER344) -- 1-AMINO 2,4-DIBROMOANTHRAQUINONE
                       TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE                   |         UNTREATE           0.2%               0.5%               1.0%               2.0%                |
|                       |         D 71UF             71LF               71MLF              71MHF              FEMALE              |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral/Preputial Gland                                                                                                         |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                                                                         |
|-----------            |                                                                                                         |
|OVERALL (a)            |        5/65 (8%)          3/46 (7%)          3/68 (4%)          2/58 (3%)          0/37 (0%)            |
|ADJUSTED (b)           |        13.3%              10.0%               7.4%              10.8%               0.0%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/8 (0%)           0/10 (0%)          0/9 (0%)             |
|INTERIM SACRIFICE 2 (c)|        0/10 (0%)          0/0                0/0                0/3 (0%)           0/20 (0%)            |
|TERMINAL (d)           |        4/36 (11%)         3/30 (10%)         2/38 (5%)          1/12 (8%)          0/0                  |
|FIRST INCIDENCE (DAYS) |         708                729 (T)            696                610                ---                 |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P=0.613N           P=0.465N           P=0.330N           P=0.664              (e)                |
|INCIDENTAL TUMOR       |        P=0.337N           P=0.495N           P=0.225N           P=0.377N             (e)                |
|LOGISTIC REGRESSION    |        P=0.344N           P=0.489N           P=0.268N           P=0.414N             (e)                |
|COCHRAN-ARMITAGE       |        P=0.050N                                                                                         |
|FISHER EXACT           |                           P=0.562N           P=0.334N           P=0.269N           P=0.099N             |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral/Preputial Gland                                                                                                         |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                                                                         |
|-----------            |                                                                                                         |
|OVERALL (a)            |        5/65 (8%)          3/46 (7%)          3/68 (4%)          2/58 (3%)          0/37 (0%)            |
|ADJUSTED (b)           |        13.3%              10.0%               7.4%              10.8%               0.0%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/8 (0%)           0/10 (0%)          0/9 (0%)             |
|INTERIM SACRIFICE 2 (c)|        0/10 (0%)          0/0                0/0                0/3 (0%)           0/20 (0%)            |
|TERMINAL (d)           |        4/36 (11%)         3/30 (10%)         2/38 (5%)          1/12 (8%)          0/0                  |
|FIRST INCIDENCE (DAYS) |         708                729 (T)            696                610                ---                 |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P=0.613N           P=0.465N           P=0.330N           P=0.664              (e)                |
|INCIDENTAL TUMOR       |        P=0.337N           P=0.495N           P=0.225N           P=0.377N             (e)                |
|LOGISTIC REGRESSION    |        P=0.344N           P=0.489N           P=0.268N           P=0.414N             (e)                |
|COCHRAN-ARMITAGE       |        P=0.050N                                                                                         |
|FISHER EXACT           |                           P=0.562N           P=0.334N           P=0.269N           P=0.099N             |
|=================================================================================================================================|
         DATE: 05/19/95                     EXPERIMENT: 05061 TEST: 01                                                 PAGE  35
                  STATISTICAL ANALYSIS OF PRIMARY TUMORS IN FEMALE RATS(FISCHER344) -- 1-AMINO 2,4-DIBROMOANTHRAQUINONE
                       TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE                   |         UNTREATE           0.2%               0.5%               1.0%               2.0%                |
|                       |         D 71UF             71LF               71MLF              71MHF              FEMALE              |
|=================================================================================================================================|
|                                                                                                                                 |
|Intestine Large: Colon/Rectum                                                                                                    |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |          #                  #                  #                  #                  #                  |
|-----------            |                                                                                                         |
|OVERALL (a)            |        0/70 (0%)          2/50 (4%)         21/70 (30%)         8/69 (12%)         0/38 (0%)            |
|ADJUSTED (b)           |         0.0%               6.3%              45.1%              46.3%               0.0%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 2 (c)|        0/10 (0%)          0/0                0/0                0/10 (0%)          0/20 (0%)            |
|TERMINAL (d)           |        0/38 (0%)          2/32 (6%)         14/38 (37%)         4/12 (33%)         0/0                  |
|FIRST INCIDENCE (DAYS) |         ---                729 (T)            606                625                ---                 |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P<0.001 **         P=0.201            P<0.001 **         P<0.001 **           (e)                |
|INCIDENTAL TUMOR       |        P<0.001 **         P=0.201            P<0.001 **         P=0.001 **           (e)                |
|LOGISTIC REGRESSION    |        P=0.002 **         P=0.201            P<0.001 **         P<0.001 **           (e)                |
|COCHRAN-ARMITAGE       |        P=0.449N                                                                                         |
|FISHER EXACT           |                           P=0.172            P<0.001 **         P=0.003 **           (e)                |
|=================================================================================================================================|
|                                                                                                                                 |
|Intestine Large: Colon/Rectum                                                                                                    |
|     Polyp Adenomatous                                                                                                           |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |          #                  #                  #                  #                  #                  |
|-----------            |                                                                                                         |
|OVERALL (a)            |        0/70 (0%)         28/50 (56%)        53/70 (76%)        45/69 (65%)         8/38 (21%)           |
|ADJUSTED (b)           |         0.0%              77.7%             100.0%             100.0%              35.4%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 2 (c)|        0/10 (0%)          0/0                0/0                2/10 (20%)         6/20 (30%)           |
|TERMINAL (d)           |        0/38 (0%)         24/32 (75%)        38/38 (100%)       12/12 (100%)        0/0                  |
|FIRST INCIDENCE (DAYS) |         ---                616                582                462 (I)            306                 |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P<0.001 **         P<0.001 **         P<0.001 **         P<0.001 **         P=0.009 **           |
|INCIDENTAL TUMOR       |        P<0.001 **         P<0.001 **         P<0.001 **         P<0.001 **         P=0.062              |
|LOGISTIC REGRESSION    |        P<0.001 **         P<0.001 **         P<0.001 **         P<0.001 **         P=0.002 **           |
|COCHRAN-ARMITAGE       |        P=0.103                                                                                          |
|FISHER EXACT           |                           P<0.001 **         P<0.001 **         P<0.001 **         P<0.001 **           |
|=================================================================================================================================|
         DATE: 05/19/95                     EXPERIMENT: 05061 TEST: 01                                                 PAGE  36
                  STATISTICAL ANALYSIS OF PRIMARY TUMORS IN FEMALE RATS(FISCHER344) -- 1-AMINO 2,4-DIBROMOANTHRAQUINONE
                       TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE                   |         UNTREATE           0.2%               0.5%               1.0%               2.0%                |
|                       |         D 71UF             71LF               71MLF              71MHF              FEMALE              |
|=================================================================================================================================|
|                                                                                                                                 |
|Islets, Pancreatic                                                                                                               |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                                                                         |
|-----------            |                                                                                                         |
|OVERALL (a)            |        0/50 (0%)          1/40 (3%)          0/60 (0%)          0/47 (0%)          0/8 (0%)             |
|ADJUSTED (b)           |         0.0%               3.1%               0.0%               0.0%               0.0%                |
|INTERIM SACRIFICE 1 (c)|        0/0                0/0                0/0                0/0                0/0                  |
|INTERIM SACRIFICE 2 (c)|        0/0                0/0                0/0                0/0                0/0                  |
|TERMINAL (d)           |        0/38 (0%)          1/32 (3%)          0/38 (0%)          0/12 (0%)          0/0                  |
|FIRST INCIDENCE (DAYS) |         ---                729 (T)            ---                ---                ---                 |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P=0.899N           P=0.466              (e)                (e)                (e)                |
|INCIDENTAL TUMOR       |        P=0.899N           P=0.466              (e)                (e)                (e)                |
|LOGISTIC REGRESSION    |        P=0.899N           P=0.466              (e)                (e)                (e)                |
|COCHRAN-ARMITAGE       |        P=0.670N                                                                                         |
|FISHER EXACT           |                           P=0.444              (e)                (e)                (e)                |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney: Renal Tubule                                                                                                             |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                                                                         |
|-----------            |                                                                                                         |
|OVERALL (a)            |        0/70 (0%)          3/50 (6%)         16/70 (23%)        16/68 (24%)         6/38 (16%)           |
|ADJUSTED (b)           |         0.0%               8.0%              36.0%              69.7%              27.0%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          1/10 (10%)           |
|INTERIM SACRIFICE 2 (c)|        0/10 (0%)          0/0                0/0                0/10 (0%)          5/20 (25%)           |
|TERMINAL (d)           |        0/38 (0%)          1/32 (3%)         11/38 (29%)         6/12 (50%)         0/0                  |
|FIRST INCIDENCE (DAYS) |         ---                600                601                625                279 (I)             |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P<0.001 **         P=0.093            P<0.001 **         P<0.001 **         P=0.065              |
|INCIDENTAL TUMOR       |        P<0.001 **         P=0.072            P<0.001 **         P<0.001 **         P=0.065              |
|LOGISTIC REGRESSION    |        P<0.001 **         P=0.071            P<0.001 **         P<0.001 **         P=0.010 *            |
|COCHRAN-ARMITAGE       |        P=0.004 **                                                                                       |
|FISHER EXACT           |                           P=0.070            P<0.001 **         P<0.001 **         P=0.001 **           |
|=================================================================================================================================|
         DATE: 05/19/95                     EXPERIMENT: 05061 TEST: 01                                                 PAGE  37
                  STATISTICAL ANALYSIS OF PRIMARY TUMORS IN FEMALE RATS(FISCHER344) -- 1-AMINO 2,4-DIBROMOANTHRAQUINONE
                       TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE                   |         UNTREATE           0.2%               0.5%               1.0%               2.0%                |
|                       |         D 71UF             71LF               71MLF              71MHF              FEMALE              |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney: Renal Tubule                                                                                                             |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                                                                         |
|-----------            |                                                                                                         |
|OVERALL (a)            |        0/70 (0%)          0/50 (0%)          0/70 (0%)          2/68 (3%)          0/38 (0%)            |
|ADJUSTED (b)           |         0.0%               0.0%               0.0%              12.9%               0.0%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 2 (c)|        0/10 (0%)          0/0                0/0                0/10 (0%)          0/20 (0%)            |
|TERMINAL (d)           |        0/38 (0%)          0/32 (0%)          0/38 (0%)          1/12 (8%)          0/0                  |
|FIRST INCIDENCE (DAYS) |         ---                ---                ---                702                ---                 |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P=0.032 *            (e)                (e)              P=0.069              (e)                |
|INCIDENTAL TUMOR       |        P=0.100              (e)                (e)              P=0.184              (e)                |
|LOGISTIC REGRESSION    |        P=0.062              (e)                (e)              P=0.115              (e)                |
|COCHRAN-ARMITAGE       |        P=0.401                                                                                          |
|FISHER EXACT           |                             (e)                (e)              P=0.241              (e)                |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney: Renal Tubule                                                                                                             |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                                                                         |
|-----------            |                                                                                                         |
|OVERALL (a)            |        0/70 (0%)          3/50 (6%)         16/70 (23%)        16/68 (24%)         6/38 (16%)           |
|ADJUSTED (b)           |         0.0%               8.0%              36.0%              69.7%              27.0%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          1/10 (10%)           |
|INTERIM SACRIFICE 2 (c)|        0/10 (0%)          0/0                0/0                0/10 (0%)          5/20 (25%)           |
|TERMINAL (d)           |        0/38 (0%)          1/32 (3%)         11/38 (29%)         6/12 (50%)         0/0                  |
|FIRST INCIDENCE (DAYS) |         ---                600                601                625                279 (I)             |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P<0.001 **         P=0.093            P<0.001 **         P<0.001 **         P=0.065              |
|INCIDENTAL TUMOR       |        P<0.001 **         P=0.072            P<0.001 **         P<0.001 **         P=0.065              |
|LOGISTIC REGRESSION    |        P<0.001 **         P=0.071            P<0.001 **         P<0.001 **         P=0.010 *            |
|COCHRAN-ARMITAGE       |        P=0.004 **                                                                                       |
|FISHER EXACT           |                           P=0.070            P<0.001 **         P<0.001 **         P=0.001 **           |
|=================================================================================================================================|
         DATE: 05/19/95                     EXPERIMENT: 05061 TEST: 01                                                 PAGE  38
                  STATISTICAL ANALYSIS OF PRIMARY TUMORS IN FEMALE RATS(FISCHER344) -- 1-AMINO 2,4-DIBROMOANTHRAQUINONE
                       TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE                   |         UNTREATE           0.2%               0.5%               1.0%               2.0%                |
|                       |         D 71UF             71LF               71MLF              71MHF              FEMALE              |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Cholangioma                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                                                                         |
|-----------            |                                                                                                         |
|OVERALL (a)            |        0/70 (0%)          0/50 (0%)          0/70 (0%)          1/68 (1%)          0/38 (0%)            |
|ADJUSTED (b)           |         0.0%               0.0%               0.0%               6.7%               0.0%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 2 (c)|        0/10 (0%)          0/0                0/0                0/10 (0%)          0/20 (0%)            |
|TERMINAL (d)           |        0/38 (0%)          0/32 (0%)          0/38 (0%)          0/12 (0%)          0/0                  |
|FIRST INCIDENCE (DAYS) |         ---                ---                ---                719                ---                 |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P=0.294              (e)                (e)              P=0.310              (e)                |
|INCIDENTAL TUMOR       |        P=0.574              (e)                (e)              P=0.665              (e)                |
|LOGISTIC REGRESSION    |        P=0.348              (e)                (e)              P=0.369              (e)                |
|COCHRAN-ARMITAGE       |        P=0.587                                                                                          |
|FISHER EXACT           |                             (e)                (e)              P=0.493              (e)                |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Adenoma                                                                                                      |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                                                                         |
|-----------            |                                                                                                         |
|OVERALL (a)            |        0/70 (0%)         28/50 (56%)        47/70 (67%)        37/68 (54%)        18/38 (47%)           |
|ADJUSTED (b)           |         0.0%              75.5%              83.7%              85.9%              73.9%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          2/10 (20%)           |
|INTERIM SACRIFICE 2 (c)|        0/10 (0%)          0/0                0/0                8/10 (80%)        14/20 (70%)           |
|TERMINAL (d)           |        0/38 (0%)         23/32 (72%)        29/38 (76%)         8/12 (67%)         0/0                  |
|FIRST INCIDENCE (DAYS) |         ---                600                575                418                279 (I)             |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P<0.001 **         P<0.001 **         P<0.001 **         P<0.001 **         P<0.001 **           |
|INCIDENTAL TUMOR       |        P<0.001 **         P<0.001 **         P<0.001 **         P<0.001 **         P<0.001 **           |
|LOGISTIC REGRESSION    |        P<0.001 **         P<0.001 **         P<0.001 **         P<0.001 **         P<0.001 **           |
|COCHRAN-ARMITAGE       |        P<0.001 **                                                                                       |
|FISHER EXACT           |                           P<0.001 **         P<0.001 **         P<0.001 **         P<0.001 **           |
|=================================================================================================================================|
         DATE: 05/19/95                     EXPERIMENT: 05061 TEST: 01                                                 PAGE  39
                  STATISTICAL ANALYSIS OF PRIMARY TUMORS IN FEMALE RATS(FISCHER344) -- 1-AMINO 2,4-DIBROMOANTHRAQUINONE
                       TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE                   |         UNTREATE           0.2%               0.5%               1.0%               2.0%                |
|                       |         D 71UF             71LF               71MLF              71MHF              FEMALE              |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma                                                                                                    |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                                                                         |
|-----------            |                                                                                                         |
|OVERALL (a)            |        0/70 (0%)         12/50 (24%)        57/70 (81%)        51/68 (75%)        22/38 (58%)           |
|ADJUSTED (b)           |         0.0%              37.5%              98.3%             100.0%              87.8%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          1/10 (10%)           |
|INTERIM SACRIFICE 2 (c)|        0/10 (0%)          0/0                0/0                6/10 (60%)        17/20 (85%)           |
|TERMINAL (d)           |        0/38 (0%)         12/32 (38%)        37/38 (97%)        12/12 (100%)        0/0                  |
|FIRST INCIDENCE (DAYS) |         ---                729 (T)            575                460                279 (I)             |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P<0.001 **         P<0.001 **         P<0.001 **         P<0.001 **         P<0.001 **           |
|INCIDENTAL TUMOR       |        P<0.001 **         P<0.001 **         P<0.001 **         P<0.001 **         P<0.001 **           |
|LOGISTIC REGRESSION    |        P<0.001 **         P<0.001 **         P<0.001 **         P<0.001 **         P<0.001 **           |
|COCHRAN-ARMITAGE       |        P<0.001 **                                                                                       |
|FISHER EXACT           |                           P<0.001 **         P<0.001 **         P<0.001 **         P<0.001 **           |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma or Hepatocellular Adenoma                                                                          |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                                                                         |
|-----------            |                                                                                                         |
|OVERALL (a)            |        0/70 (0%)         33/50 (66%)        59/70 (84%)        56/68 (82%)        27/38 (71%)           |
|ADJUSTED (b)           |         0.0%              89.1%             100.0%             100.0%              92.9%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          3/10 (30%)           |
|INTERIM SACRIFICE 2 (c)|        0/10 (0%)          0/0                0/0                9/10 (90%)        18/20 (90%)           |
|TERMINAL (d)           |        0/38 (0%)         28/32 (88%)        38/38 (100%)       12/12 (100%)        0/0                  |
|FIRST INCIDENCE (DAYS) |         ---                600                575                418                279 (I)             |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P<0.001 **         P<0.001 **         P<0.001 **         P<0.001 **         P<0.001 **           |
|INCIDENTAL TUMOR       |        P<0.001 **         P<0.001 **         P<0.001 **         P<0.001 **         P<0.001 **           |
|LOGISTIC REGRESSION    |        P<0.001 **         P<0.001 **         P<0.001 **         P<0.001 **         P<0.001 **           |
|COCHRAN-ARMITAGE       |        P<0.001 **                                                                                       |
|FISHER EXACT           |                           P<0.001 **         P<0.001 **         P<0.001 **         P<0.001 **           |
|=================================================================================================================================|
         DATE: 05/19/95                     EXPERIMENT: 05061 TEST: 01                                                 PAGE  40
                  STATISTICAL ANALYSIS OF PRIMARY TUMORS IN FEMALE RATS(FISCHER344) -- 1-AMINO 2,4-DIBROMOANTHRAQUINONE
                       TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE                   |         UNTREATE           0.2%               0.5%               1.0%               2.0%                |
|                       |         D 71UF             71LF               71MLF              71MHF              FEMALE              |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma                                                         |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                                                                         |
|-----------            |                                                                                                         |
|OVERALL (a)            |        0/70 (0%)         33/50 (66%)        59/70 (84%)        56/68 (82%)        27/38 (71%)           |
|ADJUSTED (b)           |         0.0%              89.1%             100.0%             100.0%              92.9%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          3/10 (30%)           |
|INTERIM SACRIFICE 2 (c)|        0/10 (0%)          0/0                0/0                9/10 (90%)        18/20 (90%)           |
|TERMINAL (d)           |        0/38 (0%)         28/32 (88%)        38/38 (100%)       12/12 (100%)        0/0                  |
|FIRST INCIDENCE (DAYS) |         ---                600                575                418                279 (I)             |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P<0.001 **         P<0.001 **         P<0.001 **         P<0.001 **         P<0.001 **           |
|INCIDENTAL TUMOR       |        P<0.001 **         P<0.001 **         P<0.001 **         P<0.001 **         P<0.001 **           |
|LOGISTIC REGRESSION    |        P<0.001 **         P<0.001 **         P<0.001 **         P<0.001 **         P<0.001 **           |
|COCHRAN-ARMITAGE       |        P<0.001 **                                                                                       |
|FISHER EXACT           |                           P<0.001 **         P<0.001 **         P<0.001 **         P<0.001 **           |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocholangiocarcinoma                                                                                                    |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                                                                         |
|-----------            |                                                                                                         |
|OVERALL (a)            |        0/70 (0%)          0/50 (0%)         11/70 (16%)        13/68 (19%)         0/38 (0%)            |
|ADJUSTED (b)           |         0.0%               0.0%              27.1%              56.9%               0.0%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 2 (c)|        0/10 (0%)          0/0                0/0                0/10 (0%)          0/20 (0%)            |
|TERMINAL (d)           |        0/38 (0%)          0/32 (0%)          9/38 (24%)         5/12 (42%)         0/0                  |
|FIRST INCIDENCE (DAYS) |         ---                ---                670                600                ---                 |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P<0.001 **           (e)              P<0.001 **         P<0.001 **           (e)                |
|INCIDENTAL TUMOR       |        P<0.001 **           (e)              P=0.001 **         P<0.001 **           (e)                |
|LOGISTIC REGRESSION    |        P<0.001 **           (e)              P=0.001 **         P<0.001 **           (e)                |
|COCHRAN-ARMITAGE       |        P=0.184                                                                                          |
|FISHER EXACT           |                             (e)              P<0.001 **         P<0.001 **           (e)                |
|=================================================================================================================================|
         DATE: 05/19/95                     EXPERIMENT: 05061 TEST: 01                                                 PAGE  41
                  STATISTICAL ANALYSIS OF PRIMARY TUMORS IN FEMALE RATS(FISCHER344) -- 1-AMINO 2,4-DIBROMOANTHRAQUINONE
                       TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE                   |         UNTREATE           0.2%               0.5%               1.0%               2.0%                |
|                       |         D 71UF             71LF               71MLF              71MHF              FEMALE              |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocholangioma                                                                                                           |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                                                                         |
|-----------            |                                                                                                         |
|OVERALL (a)            |        0/70 (0%)          0/50 (0%)          2/70 (3%)          0/68 (0%)          0/38 (0%)            |
|ADJUSTED (b)           |         0.0%               0.0%               5.3%               0.0%               0.0%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 2 (c)|        0/10 (0%)          0/0                0/0                0/10 (0%)          0/20 (0%)            |
|TERMINAL (d)           |        0/38 (0%)          0/32 (0%)          2/38 (5%)          0/12 (0%)          0/0                  |
|FIRST INCIDENCE (DAYS) |         ---                ---                729 (T)            ---                ---                 |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P=0.613              (e)              P=0.238              (e)                (e)                |
|INCIDENTAL TUMOR       |        P=0.613              (e)              P=0.238              (e)                (e)                |
|LOGISTIC REGRESSION    |        P=0.613              (e)              P=0.238              (e)                (e)                |
|COCHRAN-ARMITAGE       |        P=0.599N                                                                                         |
|FISHER EXACT           |                             (e)              P=0.248              (e)                (e)                |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Adenoma                                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                                                                         |
|-----------            |                                                                                                         |
|OVERALL (a)            |        1/70 (1%)          3/50 (6%)          1/70 (1%)          0/64 (0%)          0/38 (0%)            |
|ADJUSTED (b)           |         2.5%               9.4%               1.9%               0.0%               0.0%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 2 (c)|        0/10 (0%)          0/0                0/0                0/5 (0%)           0/20 (0%)            |
|TERMINAL (d)           |        0/38 (0%)          3/32 (9%)          0/38 (0%)          0/12 (0%)          0/0                  |
|FIRST INCIDENCE (DAYS) |         716                729 (T)            647                ---                ---                 |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P=0.476N           P=0.244            P=0.739N           P=0.695N             (e)                |
|INCIDENTAL TUMOR       |        P=0.260N           P=0.234            P=0.584N           P=0.335N             (e)                |
|LOGISTIC REGRESSION    |        P=0.307N           P=0.229            P=0.746N           P=0.619N             (e)                |
|COCHRAN-ARMITAGE       |        P=0.133N                                                                                         |
|FISHER EXACT           |                           P=0.195            P=0.752N           P=0.522N           P=0.648N             |
|=================================================================================================================================|
         DATE: 05/19/95                     EXPERIMENT: 05061 TEST: 01                                                 PAGE  42
                  STATISTICAL ANALYSIS OF PRIMARY TUMORS IN FEMALE RATS(FISCHER344) -- 1-AMINO 2,4-DIBROMOANTHRAQUINONE
                       TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE                   |         UNTREATE           0.2%               0.5%               1.0%               2.0%                |
|                       |         D 71UF             71LF               71MLF              71MHF              FEMALE              |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Carcinoma                                                                                              |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                                                                         |
|-----------            |                                                                                                         |
|OVERALL (a)            |        0/70 (0%)          0/50 (0%)          0/70 (0%)          1/64 (2%)          0/38 (0%)            |
|ADJUSTED (b)           |         0.0%               0.0%               0.0%               5.0%               0.0%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 2 (c)|        0/10 (0%)          0/0                0/0                0/5 (0%)           0/20 (0%)            |
|TERMINAL (d)           |        0/38 (0%)          0/32 (0%)          0/38 (0%)          0/12 (0%)          0/0                  |
|FIRST INCIDENCE (DAYS) |         ---                ---                ---                702                ---                 |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P=0.326              (e)                (e)              P=0.352              (e)                |
|INCIDENTAL TUMOR       |        P=0.574              (e)                (e)              P=0.665              (e)                |
|LOGISTIC REGRESSION    |        P=0.416              (e)                (e)              P=0.417              (e)                |
|COCHRAN-ARMITAGE       |        P=0.583                                                                                          |
|FISHER EXACT           |                             (e)                (e)              P=0.478              (e)                |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma                                                              |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                                                                         |
|-----------            |                                                                                                         |
|OVERALL (a)            |        1/70 (1%)          3/50 (6%)          1/70 (1%)          1/64 (2%)          0/38 (0%)            |
|ADJUSTED (b)           |         2.5%               9.4%               1.9%               5.0%               0.0%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 2 (c)|        0/10 (0%)          0/0                0/0                0/5 (0%)           0/20 (0%)            |
|TERMINAL (d)           |        0/38 (0%)          3/32 (9%)          0/38 (0%)          0/12 (0%)          0/0                  |
|FIRST INCIDENCE (DAYS) |         716                729 (T)            647                702                ---                 |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P=0.693            P=0.244            P=0.739N           P=0.559              (e)                |
|INCIDENTAL TUMOR       |        P=0.478N           P=0.234            P=0.584N           P=0.568N             (e)                |
|LOGISTIC REGRESSION    |        P=0.584N           P=0.229            P=0.746N           P=0.660              (e)                |
|COCHRAN-ARMITAGE       |        P=0.218N                                                                                         |
|FISHER EXACT           |                           P=0.195            P=0.752N           P=0.729            P=0.648N             |
|=================================================================================================================================|
         DATE: 05/19/95                     EXPERIMENT: 05061 TEST: 01                                                 PAGE  43
                  STATISTICAL ANALYSIS OF PRIMARY TUMORS IN FEMALE RATS(FISCHER344) -- 1-AMINO 2,4-DIBROMOANTHRAQUINONE
                       TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE                   |         UNTREATE           0.2%               0.5%               1.0%               2.0%                |
|                       |         D 71UF             71LF               71MLF              71MHF              FEMALE              |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |          #                  #                  #                  #                  #                  |
|-----------            |                                                                                                         |
|OVERALL (a)            |        2/70 (3%)          0/50 (0%)          0/70 (0%)          0/69 (0%)          0/38 (0%)            |
|ADJUSTED (b)           |         5.3%               0.0%               0.0%               0.0%               0.0%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 2 (c)|        0/10 (0%)          0/0                0/0                0/10 (0%)          0/20 (0%)            |
|TERMINAL (d)           |        2/38 (5%)          0/32 (0%)          0/38 (0%)          0/12 (0%)          0/0                  |
|FIRST INCIDENCE (DAYS) |         729 (T)            ---                ---                ---                ---                 |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P=0.387N           P=0.277N           P=0.238N           P=0.513N             (e)                |
|INCIDENTAL TUMOR       |        P=0.387N           P=0.277N           P=0.238N           P=0.513N             (e)                |
|LOGISTIC REGRESSION    |        P=0.387N           P=0.277N           P=0.238N           P=0.513N             (e)                |
|COCHRAN-ARMITAGE       |        P=0.191N                                                                                         |
|FISHER EXACT           |                           P=0.338N           P=0.248N           P=0.252N           P=0.418N             |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Fibroadenoma                                                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |          #                  #                  #                  #                  #                  |
|-----------            |                                                                                                         |
|OVERALL (a)            |       22/70 (31%)        10/50 (20%)         9/70 (13%)         5/69 (7%)          0/38 (0%)            |
|ADJUSTED (b)           |        53.0%              29.1%              20.7%              22.3%               0.0%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 2 (c)|        1/10 (10%)         0/0                0/0                0/10 (0%)          0/20 (0%)            |
|TERMINAL (d)           |       19/38 (50%)         8/32 (25%)         6/38 (16%)         1/12 (8%)          0/0                  |
|FIRST INCIDENCE (DAYS) |         462 (I)            659                582                610                ---                 |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P=0.027N*          P=0.055N           P=0.008N**         P=0.150N           P=0.362N             |
|INCIDENTAL TUMOR       |        P<0.001N**         P=0.058N           P=0.003N**         P=0.011N*          P=0.362N             |
|LOGISTIC REGRESSION    |        P<0.001N**         P=0.057N           P=0.002N**         P=0.004N**         P=0.385N             |
|COCHRAN-ARMITAGE       |        P<0.001N**                                                                                       |
|FISHER EXACT           |                           P=0.117N           P=0.007N**         P<0.001N**         P<0.001N**           |
|=================================================================================================================================|
         DATE: 05/19/95                     EXPERIMENT: 05061 TEST: 01                                                 PAGE  44
                  STATISTICAL ANALYSIS OF PRIMARY TUMORS IN FEMALE RATS(FISCHER344) -- 1-AMINO 2,4-DIBROMOANTHRAQUINONE
                       TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE                   |         UNTREATE           0.2%               0.5%               1.0%               2.0%                |
|                       |         D 71UF             71LF               71MLF              71MHF              FEMALE              |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Fibroma, Fibroadenoma or Adenoma                                                                                            |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |          #                  #                  #                  #                  #                  |
|-----------            |                                                                                                         |
|OVERALL (a)            |       22/70 (31%)        10/50 (20%)         9/70 (13%)         5/69 (7%)          0/38 (0%)            |
|ADJUSTED (b)           |        53.0%              29.1%              20.7%              22.3%               0.0%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 2 (c)|        1/10 (10%)         0/0                0/0                0/10 (0%)          0/20 (0%)            |
|TERMINAL (d)           |       19/38 (50%)         8/32 (25%)         6/38 (16%)         1/12 (8%)          0/0                  |
|FIRST INCIDENCE (DAYS) |         462 (I)            659                582                610                ---                 |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P=0.027N*          P=0.055N           P=0.008N**         P=0.150N           P=0.362N             |
|INCIDENTAL TUMOR       |        P<0.001N**         P=0.058N           P=0.003N**         P=0.011N*          P=0.362N             |
|LOGISTIC REGRESSION    |        P<0.001N**         P=0.057N           P=0.002N**         P=0.004N**         P=0.385N             |
|COCHRAN-ARMITAGE       |        P<0.001N**                                                                                       |
|FISHER EXACT           |                           P=0.117N           P=0.007N**         P<0.001N**         P<0.001N**           |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Fibroma, Fibroadenoma, Carcinoma, or Adenoma                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |          #                  #                  #                  #                  #                  |
|-----------            |                                                                                                         |
|OVERALL (a)            |       24/70 (34%)        10/50 (20%)         9/70 (13%)         5/69 (7%)          0/38 (0%)            |
|ADJUSTED (b)           |        58.0%              29.1%              20.7%              22.3%               0.0%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 2 (c)|        1/10 (10%)         0/0                0/0                0/10 (0%)          0/20 (0%)            |
|TERMINAL (d)           |       21/38 (55%)         8/32 (25%)         6/38 (16%)         1/12 (8%)          0/0                  |
|FIRST INCIDENCE (DAYS) |         462 (I)            659                582                610                ---                 |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P=0.014N*          P=0.024N*          P=0.003N**         P=0.102N           P=0.362N             |
|INCIDENTAL TUMOR       |        P<0.001N**         P=0.025N*          P<0.001N**         P=0.006N**         P=0.362N             |
|LOGISTIC REGRESSION    |        P<0.001N**         P=0.025N*          P<0.001N**         P=0.002N**         P=0.406N             |
|COCHRAN-ARMITAGE       |        P<0.001N**                                                                                       |
|FISHER EXACT           |                           P=0.065N           P=0.002N**         P<0.001N**         P<0.001N**           |
|=================================================================================================================================|
         DATE: 05/19/95                     EXPERIMENT: 05061 TEST: 01                                                 PAGE  45
                  STATISTICAL ANALYSIS OF PRIMARY TUMORS IN FEMALE RATS(FISCHER344) -- 1-AMINO 2,4-DIBROMOANTHRAQUINONE
                       TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE                   |         UNTREATE           0.2%               0.5%               1.0%               2.0%                |
|                       |         D 71UF             71LF               71MLF              71MHF              FEMALE              |
|=================================================================================================================================|
|                                                                                                                                 |
|Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Gingiva)                                                                       |
|     Squamous Cell Carcinoma, Papilloma Squamous, or Papilloma                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |          #                  #                  #                  #                  #                  |
|-----------            |                                                                                                         |
|OVERALL (a)            |        0/70 (0%)          1/50 (2%)          0/70 (0%)          2/69 (3%)          0/38 (0%)            |
|ADJUSTED (b)           |         0.0%               3.1%               0.0%              10.4%               0.0%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 2 (c)|        0/10 (0%)          0/0                0/0                0/10 (0%)          0/20 (0%)            |
|TERMINAL (d)           |        0/38 (0%)          1/32 (3%)          0/38 (0%)          1/12 (8%)          0/0                  |
|FIRST INCIDENCE (DAYS) |         ---                729 (T)            ---                559                ---                 |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P=0.124            P=0.466              (e)              P=0.116              (e)                |
|INCIDENTAL TUMOR       |        P=0.240            P=0.466              (e)              P=0.216              (e)                |
|LOGISTIC REGRESSION    |        P=0.379            P=0.466              (e)              P=0.206              (e)                |
|COCHRAN-ARMITAGE       |        P=0.580                                                                                          |
|FISHER EXACT           |                           P=0.417              (e)              P=0.245              (e)                |
|=================================================================================================================================|
|                                                                                                                                 |
|Pancreas                                                                                                                         |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                                                                         |
|-----------            |                                                                                                         |
|OVERALL (a)            |        0/70 (0%)          0/50 (0%)          2/70 (3%)          0/58 (0%)          0/38 (0%)            |
|ADJUSTED (b)           |         0.0%               0.0%               4.7%               0.0%               0.0%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 2 (c)|        0/10 (0%)          0/0                0/0                0/1 (0%)           0/20 (0%)            |
|TERMINAL (d)           |        0/38 (0%)          0/32 (0%)          1/38 (3%)          0/12 (0%)          0/0                  |
|FIRST INCIDENCE (DAYS) |         ---                ---                691                ---                ---                 |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P=0.646              (e)              P=0.250              (e)                (e)                |
|INCIDENTAL TUMOR       |        P=0.780              (e)              P=0.321              (e)                (e)                |
|LOGISTIC REGRESSION    |        P=0.720              (e)              P=0.262              (e)                (e)                |
|COCHRAN-ARMITAGE       |        P=0.608N                                                                                         |
|FISHER EXACT           |                             (e)              P=0.248              (e)                (e)                |
|=================================================================================================================================|
         DATE: 05/19/95                     EXPERIMENT: 05061 TEST: 01                                                 PAGE  46
                  STATISTICAL ANALYSIS OF PRIMARY TUMORS IN FEMALE RATS(FISCHER344) -- 1-AMINO 2,4-DIBROMOANTHRAQUINONE
                       TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE                   |         UNTREATE           0.2%               0.5%               1.0%               2.0%                |
|                       |         D 71UF             71LF               71MLF              71MHF              FEMALE              |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                                                                         |
|-----------            |                                                                                                         |
|OVERALL (a)            |       34/70 (49%)        19/49 (39%)        32/70 (46%)        13/57 (23%)         4/38 (11%)           |
|ADJUSTED (b)           |        75.2%              55.6%              62.3%              55.7%              15.9%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          1/10 (10%)           |
|INTERIM SACRIFICE 2 (c)|        2/10 (20%)         0/0                0/0                0/0                1/20 (5%)            |
|TERMINAL (d)           |       27/38 (71%)        17/32 (53%)        19/38 (50%)         4/11 (36%)         0/0                  |
|FIRST INCIDENCE (DAYS) |         462 (I)            616                575                512                279 (I)             |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P=0.149            P=0.060N           P=0.510N           P=0.431            P=0.339              |
|INCIDENTAL TUMOR       |        P=0.021N*          P=0.071N           P=0.153N           P=0.018N*          P=0.500N             |
|LOGISTIC REGRESSION    |        P=0.105N           P=0.061N           P=0.171N           P=0.008N**         P=0.667N             |
|COCHRAN-ARMITAGE       |        P<0.001N**                                                                                       |
|FISHER EXACT           |                           P=0.192N           P=0.433N           P=0.002N**         P<0.001N**           |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                                                                         |
|-----------            |                                                                                                         |
|OVERALL (a)            |       34/70 (49%)        19/49 (39%)        32/70 (46%)        13/57 (23%)         4/38 (11%)           |
|ADJUSTED (b)           |        75.2%              55.6%              62.3%              55.7%              15.9%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          1/10 (10%)           |
|INTERIM SACRIFICE 2 (c)|        2/10 (20%)         0/0                0/0                0/0                1/20 (5%)            |
|TERMINAL (d)           |       27/38 (71%)        17/32 (53%)        19/38 (50%)         4/11 (36%)         0/0                  |
|FIRST INCIDENCE (DAYS) |         462 (I)            616                575                512                279 (I)             |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P=0.149            P=0.060N           P=0.510N           P=0.431            P=0.339              |
|INCIDENTAL TUMOR       |        P=0.021N*          P=0.071N           P=0.153N           P=0.018N*          P=0.500N             |
|LOGISTIC REGRESSION    |        P=0.105N           P=0.061N           P=0.171N           P=0.008N**         P=0.667N             |
|COCHRAN-ARMITAGE       |        P<0.001N**                                                                                       |
|FISHER EXACT           |                           P=0.192N           P=0.433N           P=0.002N**         P<0.001N**           |
|=================================================================================================================================|
         DATE: 05/19/95                     EXPERIMENT: 05061 TEST: 01                                                 PAGE  47
                  STATISTICAL ANALYSIS OF PRIMARY TUMORS IN FEMALE RATS(FISCHER344) -- 1-AMINO 2,4-DIBROMOANTHRAQUINONE
                       TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE                   |         UNTREATE           0.2%               0.5%               1.0%               2.0%                |
|                       |         D 71UF             71LF               71MLF              71MHF              FEMALE              |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Basal Cell Carcinoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |          #                  #                  #                  #                  #                  |
|-----------            |                                                                                                         |
|OVERALL (a)            |        0/70 (0%)          0/50 (0%)          0/70 (0%)          0/69 (0%)          0/38 (0%)            |
|ADJUSTED (b)           |         0.0%               0.0%               0.0%               0.0%               0.0%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 2 (c)|        0/10 (0%)          0/0                0/0                0/10 (0%)          0/20 (0%)            |
|TERMINAL (d)           |        0/38 (0%)          0/32 (0%)          0/38 (0%)          0/12 (0%)          0/0                  |
|FIRST INCIDENCE (DAYS) |         ---                ---                ---                ---                ---                 |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |          (e)                (e)                (e)                (e)                (e)                |
|INCIDENTAL TUMOR       |          (e)                (e)                (e)                (e)                (e)                |
|LOGISTIC REGRESSION    |          (e)                (e)                (e)                (e)                (e)                |
|COCHRAN-ARMITAGE       |          (e)                                                                                            |
|FISHER EXACT           |                             (e)                (e)                (e)                (e)                |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Basal Cell Carcinoma, Basal Cell Adenoma, Basosquamous Tumor (benign,                                                       |
|     malignant or NOS), or Trichoepithelioma                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |          #                  #                  #                  #                  #                  |
|-----------            |                                                                                                         |
|OVERALL (a)            |        0/70 (0%)          0/50 (0%)          0/70 (0%)          0/69 (0%)          0/38 (0%)            |
|ADJUSTED (b)           |         0.0%               0.0%               0.0%               0.0%               0.0%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 2 (c)|        0/10 (0%)          0/0                0/0                0/10 (0%)          0/20 (0%)            |
|TERMINAL (d)           |        0/38 (0%)          0/32 (0%)          0/38 (0%)          0/12 (0%)          0/0                  |
|FIRST INCIDENCE (DAYS) |         ---                ---                ---                ---                ---                 |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |          (e)                (e)                (e)                (e)                (e)                |
|INCIDENTAL TUMOR       |          (e)                (e)                (e)                (e)                (e)                |
|LOGISTIC REGRESSION    |          (e)                (e)                (e)                (e)                (e)                |
|COCHRAN-ARMITAGE       |          (e)                                                                                            |
|FISHER EXACT           |                             (e)                (e)                (e)                (e)                |
|=================================================================================================================================|
         DATE: 05/19/95                     EXPERIMENT: 05061 TEST: 01                                                 PAGE  48
                  STATISTICAL ANALYSIS OF PRIMARY TUMORS IN FEMALE RATS(FISCHER344) -- 1-AMINO 2,4-DIBROMOANTHRAQUINONE
                       TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE                   |         UNTREATE           0.2%               0.5%               1.0%               2.0%                |
|                       |         D 71UF             71LF               71MLF              71MHF              FEMALE              |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Basal or Sq. Cell Carcinoma, Carcinoma, Basosq. Tumor (M or B), Basal                                                       |
|     Cell Adenoma, Adenoma, Papilloma, Sq Papilloma, Keratoacanthoma, Trichoepithelioma                                          |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |          #                  #                  #                  #                  #                  |
|-----------            |                                                                                                         |
|OVERALL (a)            |        1/70 (1%)          0/50 (0%)          3/70 (4%)          3/69 (4%)          0/38 (0%)            |
|ADJUSTED (b)           |         2.6%               0.0%               7.9%              19.4%               0.0%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 2 (c)|        0/10 (0%)          0/0                0/0                0/10 (0%)          0/20 (0%)            |
|TERMINAL (d)           |        1/38 (3%)          0/32 (0%)          3/38 (8%)          2/12 (17%)         0/0                  |
|FIRST INCIDENCE (DAYS) |         729 (T)            ---                729 (T)            637                ---                 |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P=0.015 *          P=0.534N           P=0.305            P=0.056              (e)                |
|INCIDENTAL TUMOR       |        P=0.038 *          P=0.534N           P=0.305            P=0.118              (e)                |
|LOGISTIC REGRESSION    |        P=0.065            P=0.534N           P=0.305            P=0.156              (e)                |
|COCHRAN-ARMITAGE       |        P=0.614                                                                                          |
|FISHER EXACT           |                           P=0.583N           P=0.310            P=0.304            P=0.648N             |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Fibroma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |          #                  #                  #                  #                  #                  |
|-----------            |                                                                                                         |
|OVERALL (a)            |        2/70 (3%)          2/50 (4%)          0/70 (0%)          1/69 (1%)          0/38 (0%)            |
|ADJUSTED (b)           |         5.3%               6.0%               0.0%               1.8%               0.0%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 2 (c)|        0/10 (0%)          0/0                0/0                1/10 (10%)         0/20 (0%)            |
|TERMINAL (d)           |        2/38 (5%)          1/32 (3%)          0/38 (0%)          0/12 (0%)          0/0                  |
|FIRST INCIDENCE (DAYS) |         729 (T)            670                ---                462 (I)            ---                 |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P=0.265N           P=0.625            P=0.238N           P=0.731              (e)                |
|INCIDENTAL TUMOR       |        P=0.208N           P=0.615            P=0.238N           P=0.731              (e)                |
|LOGISTIC REGRESSION    |        P=0.267N           P=0.607            P=0.238N           P=0.542N             (e)                |
|COCHRAN-ARMITAGE       |        P=0.177N                                                                                         |
|FISHER EXACT           |                           P=0.555            P=0.248N           P=0.505N           P=0.418N             |
|=================================================================================================================================|
         DATE: 05/19/95                     EXPERIMENT: 05061 TEST: 01                                                 PAGE  49
                  STATISTICAL ANALYSIS OF PRIMARY TUMORS IN FEMALE RATS(FISCHER344) -- 1-AMINO 2,4-DIBROMOANTHRAQUINONE
                       TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE                   |         UNTREATE           0.2%               0.5%               1.0%               2.0%                |
|                       |         D 71UF             71LF               71MLF              71MHF              FEMALE              |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Fibroma, Fibrosarcoma, Sarcoma, Myxoma, Myxosarcoma, or Fibrous Histiocytoma                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |          #                  #                  #                  #                  #                  |
|-----------            |                                                                                                         |
|OVERALL (a)            |        3/70 (4%)          2/50 (4%)          0/70 (0%)          1/69 (1%)          0/38 (0%)            |
|ADJUSTED (b)           |         7.5%               6.0%               0.0%               1.8%               0.0%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 2 (c)|        0/10 (0%)          0/0                0/0                1/10 (10%)         0/20 (0%)            |
|TERMINAL (d)           |        2/38 (5%)          1/32 (3%)          0/38 (0%)          0/12 (0%)          0/0                  |
|FIRST INCIDENCE (DAYS) |         704                670                ---                462 (I)            ---                 |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P=0.181N           P=0.591N           P=0.122N           P=0.596N             (e)                |
|INCIDENTAL TUMOR       |        P=0.100N           P=0.608N           P=0.080N           P=0.423N             (e)                |
|LOGISTIC REGRESSION    |        P=0.163N           P=0.610N           P=0.103N           P=0.363N             (e)                |
|COCHRAN-ARMITAGE       |        P=0.103N                                                                                         |
|FISHER EXACT           |                           P=0.656N           P=0.122N           P=0.315N           P=0.268N             |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Fibrosarcoma, Sarcoma, Myxosarcoma, or Fibrous Histiocytoma                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |          #                  #                  #                  #                  #                  |
|-----------            |                                                                                                         |
|OVERALL (a)            |        1/70 (1%)          0/50 (0%)          0/70 (0%)          0/69 (0%)          0/38 (0%)            |
|ADJUSTED (b)           |         2.4%               0.0%               0.0%               0.0%               0.0%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 2 (c)|        0/10 (0%)          0/0                0/0                0/10 (0%)          0/20 (0%)            |
|TERMINAL (d)           |        0/38 (0%)          0/32 (0%)          0/38 (0%)          0/12 (0%)          0/0                  |
|FIRST INCIDENCE (DAYS) |         704                ---                ---                ---                ---                 |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P=0.688N           P=0.554N           P=0.495N           P=0.669N             (e)                |
|INCIDENTAL TUMOR       |        P=0.426N           P=0.567N           P=0.348N           P=0.335N             (e)                |
|LOGISTIC REGRESSION    |        P=0.592N           P=0.551N           P=0.480N           P=0.587N           P=1.000N             |
|COCHRAN-ARMITAGE       |        P=0.412N                                                                                         |
|FISHER EXACT           |                           P=0.583N           P=0.500N           P=0.504N           P=0.648N             |
|=================================================================================================================================|
         DATE: 05/19/95                     EXPERIMENT: 05061 TEST: 01                                                 PAGE  50
                  STATISTICAL ANALYSIS OF PRIMARY TUMORS IN FEMALE RATS(FISCHER344) -- 1-AMINO 2,4-DIBROMOANTHRAQUINONE
                       TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE                   |         UNTREATE           0.2%               0.5%               1.0%               2.0%                |
|                       |         D 71UF             71LF               71MLF              71MHF              FEMALE              |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Sarcoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |          #                  #                  #                  #                  #                  |
|-----------            |                                                                                                         |
|OVERALL (a)            |        1/70 (1%)          0/50 (0%)          0/70 (0%)          0/69 (0%)          0/38 (0%)            |
|ADJUSTED (b)           |         2.4%               0.0%               0.0%               0.0%               0.0%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 2 (c)|        0/10 (0%)          0/0                0/0                0/10 (0%)          0/20 (0%)            |
|TERMINAL (d)           |        0/38 (0%)          0/32 (0%)          0/38 (0%)          0/12 (0%)          0/0                  |
|FIRST INCIDENCE (DAYS) |         704                ---                ---                ---                ---                 |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P=0.688N           P=0.554N           P=0.495N           P=0.669N             (e)                |
|INCIDENTAL TUMOR       |        P=0.426N           P=0.567N           P=0.348N           P=0.335N             (e)                |
|LOGISTIC REGRESSION    |        P=0.592N           P=0.551N           P=0.480N           P=0.587N           P=1.000N             |
|COCHRAN-ARMITAGE       |        P=0.412N                                                                                         |
|FISHER EXACT           |                           P=0.583N           P=0.500N           P=0.504N           P=0.648N             |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Squamous Cell Papilloma                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |          #                  #                  #                  #                  #                  |
|-----------            |                                                                                                         |
|OVERALL (a)            |        1/70 (1%)          0/50 (0%)          3/70 (4%)          3/69 (4%)          0/38 (0%)            |
|ADJUSTED (b)           |         2.6%               0.0%               7.9%              19.4%               0.0%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 2 (c)|        0/10 (0%)          0/0                0/0                0/10 (0%)          0/20 (0%)            |
|TERMINAL (d)           |        1/38 (3%)          0/32 (0%)          3/38 (8%)          2/12 (17%)         0/0                  |
|FIRST INCIDENCE (DAYS) |         729 (T)            ---                729 (T)            637                ---                 |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P=0.015 *          P=0.534N           P=0.305            P=0.056              (e)                |
|INCIDENTAL TUMOR       |        P=0.038 *          P=0.534N           P=0.305            P=0.118              (e)                |
|LOGISTIC REGRESSION    |        P=0.065            P=0.534N           P=0.305            P=0.156              (e)                |
|COCHRAN-ARMITAGE       |        P=0.614                                                                                          |
|FISHER EXACT           |                           P=0.583N           P=0.310            P=0.304            P=0.648N             |
|=================================================================================================================================|
         DATE: 05/19/95                     EXPERIMENT: 05061 TEST: 01                                                 PAGE  51
                  STATISTICAL ANALYSIS OF PRIMARY TUMORS IN FEMALE RATS(FISCHER344) -- 1-AMINO 2,4-DIBROMOANTHRAQUINONE
                       TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE                   |         UNTREATE           0.2%               0.5%               1.0%               2.0%                |
|                       |         D 71UF             71LF               71MLF              71MHF              FEMALE              |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Squamous Cell Papilloma, Papilloma, Squamous Cell Carcinoma or Keratoacanthoma                                              |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |          #                  #                  #                  #                  #                  |
|-----------            |                                                                                                         |
|OVERALL (a)            |        1/70 (1%)          0/50 (0%)          3/70 (4%)          3/69 (4%)          0/38 (0%)            |
|ADJUSTED (b)           |         2.6%               0.0%               7.9%              19.4%               0.0%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 2 (c)|        0/10 (0%)          0/0                0/0                0/10 (0%)          0/20 (0%)            |
|TERMINAL (d)           |        1/38 (3%)          0/32 (0%)          3/38 (8%)          2/12 (17%)         0/0                  |
|FIRST INCIDENCE (DAYS) |         729 (T)            ---                729 (T)            637                ---                 |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P=0.015 *          P=0.534N           P=0.305            P=0.056              (e)                |
|INCIDENTAL TUMOR       |        P=0.038 *          P=0.534N           P=0.305            P=0.118              (e)                |
|LOGISTIC REGRESSION    |        P=0.065            P=0.534N           P=0.305            P=0.156              (e)                |
|COCHRAN-ARMITAGE       |        P=0.614                                                                                          |
|FISHER EXACT           |                           P=0.583N           P=0.310            P=0.304            P=0.648N             |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Squamous Cell Papilloma, Papilloma, or Keratoacanthoma                                                                      |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |          #                  #                  #                  #                  #                  |
|-----------            |                                                                                                         |
|OVERALL (a)            |        1/70 (1%)          0/50 (0%)          3/70 (4%)          3/69 (4%)          0/38 (0%)            |
|ADJUSTED (b)           |         2.6%               0.0%               7.9%              19.4%               0.0%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 2 (c)|        0/10 (0%)          0/0                0/0                0/10 (0%)          0/20 (0%)            |
|TERMINAL (d)           |        1/38 (3%)          0/32 (0%)          3/38 (8%)          2/12 (17%)         0/0                  |
|FIRST INCIDENCE (DAYS) |         729 (T)            ---                729 (T)            637                ---                 |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P=0.015 *          P=0.534N           P=0.305            P=0.056              (e)                |
|INCIDENTAL TUMOR       |        P=0.038 *          P=0.534N           P=0.305            P=0.118              (e)                |
|LOGISTIC REGRESSION    |        P=0.065            P=0.534N           P=0.305            P=0.156              (e)                |
|COCHRAN-ARMITAGE       |        P=0.614                                                                                          |
|FISHER EXACT           |                           P=0.583N           P=0.310            P=0.304            P=0.648N             |
|=================================================================================================================================|
         DATE: 05/19/95                     EXPERIMENT: 05061 TEST: 01                                                 PAGE  52
                  STATISTICAL ANALYSIS OF PRIMARY TUMORS IN FEMALE RATS(FISCHER344) -- 1-AMINO 2,4-DIBROMOANTHRAQUINONE
                       TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE                   |         UNTREATE           0.2%               0.5%               1.0%               2.0%                |
|                       |         D 71UF             71LF               71MLF              71MHF              FEMALE              |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach                                                                                                             |
|     Squamous Cell Carcinoma or Papilloma Squamous                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |          #                  #                  #                  #                  #                  |
|-----------            |                                                                                                         |
|OVERALL (a)            |        0/70 (0%)          1/50 (2%)          1/70 (1%)          2/69 (3%)          0/38 (0%)            |
|ADJUSTED (b)           |         0.0%               3.1%               2.4%              10.7%               0.0%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 2 (c)|        0/10 (0%)          0/0                0/0                0/10 (0%)          0/20 (0%)            |
|TERMINAL (d)           |        0/38 (0%)          1/32 (3%)          0/38 (0%)          1/12 (8%)          0/0                  |
|FIRST INCIDENCE (DAYS) |         ---                729 (T)            714                600                ---                 |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P=0.099            P=0.466            P=0.510            P=0.104              (e)                |
|INCIDENTAL TUMOR       |        P=0.312            P=0.466            P=0.652            P=0.216              (e)                |
|LOGISTIC REGRESSION    |        P=0.292            P=0.466            P=0.522            P=0.191              (e)                |
|COCHRAN-ARMITAGE       |        P=0.612                                                                                          |
|FISHER EXACT           |                           P=0.417            P=0.500            P=0.245              (e)                |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach                                                                                                             |
|     Squamous Cell Papilloma                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |          #                  #                  #                  #                  #                  |
|-----------            |                                                                                                         |
|OVERALL (a)            |        0/70 (0%)          0/50 (0%)          0/70 (0%)          1/69 (1%)          0/38 (0%)            |
|ADJUSTED (b)           |         0.0%               0.0%               0.0%               8.3%               0.0%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 2 (c)|        0/10 (0%)          0/0                0/0                0/10 (0%)          0/20 (0%)            |
|TERMINAL (d)           |        0/38 (0%)          0/32 (0%)          0/38 (0%)          1/12 (8%)          0/0                  |
|FIRST INCIDENCE (DAYS) |         ---                ---                ---                729 (T)            ---                 |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P=0.268              (e)                (e)              P=0.271              (e)                |
|INCIDENTAL TUMOR       |        P=0.268              (e)                (e)              P=0.271              (e)                |
|LOGISTIC REGRESSION    |        P=0.268              (e)                (e)              P=0.271              (e)                |
|COCHRAN-ARMITAGE       |        P=0.588                                                                                          |
|FISHER EXACT           |                             (e)                (e)              P=0.496              (e)                |
|=================================================================================================================================|
         DATE: 05/19/95                     EXPERIMENT: 05061 TEST: 01                                                 PAGE  53
                  STATISTICAL ANALYSIS OF PRIMARY TUMORS IN FEMALE RATS(FISCHER344) -- 1-AMINO 2,4-DIBROMOANTHRAQUINONE
                       TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE                   |         UNTREATE           0.2%               0.5%               1.0%               2.0%                |
|                       |         D 71UF             71LF               71MLF              71MHF              FEMALE              |
|=================================================================================================================================|
|                                                                                                                                 |
|Testes                                                                                                                           |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                                                                         |
|-----------            |                                                                                                         |
|OVERALL (a)            |                                                                                                         |
|ADJUSTED (b)           |                                                                                                         |
|INTERIM SACRIFICE 1 (c)|                                                                                                         |
|INTERIM SACRIFICE 2 (c)|                                                                                                         |
|TERMINAL (d)           |                                                                                                         |
|FIRST INCIDENCE (DAYS) |                                                                                                         |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |                                                                                                         |
|INCIDENTAL TUMOR       |                                                                                                         |
|LOGISTIC REGRESSION    |                                                                                                         |
|COCHRAN-ARMITAGE       |                                                                                                         |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: C-Cell                                                                                                            |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                                                                         |
|-----------            |                                                                                                         |
|OVERALL (a)            |        5/70 (7%)          5/50 (10%)         5/70 (7%)          1/59 (2%)          0/38 (0%)            |
|ADJUSTED (b)           |        13.2%              15.6%              12.7%               6.7%               0.0%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 2 (c)|        0/10 (0%)          0/0                0/0                0/0                0/20 (0%)            |
|TERMINAL (d)           |        5/38 (13%)         5/32 (16%)         4/38 (11%)         0/12 (0%)          0/0                  |
|FIRST INCIDENCE (DAYS) |         729 (T)            729 (T)            714                719                ---                 |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P=0.489N           P=0.519            P=0.627N           P=0.509N             (e)                |
|INCIDENTAL TUMOR       |        P=0.337N           P=0.519            P=0.584N           P=0.350N             (e)                |
|LOGISTIC REGRESSION    |        P=0.380N           P=0.519            P=0.604N           P=0.421N             (e)                |
|COCHRAN-ARMITAGE       |        P=0.022N*                                                                                        |
|FISHER EXACT           |                           P=0.406            P=0.628N           P=0.149N           P=0.109N             |
|=================================================================================================================================|
         DATE: 05/19/95                     EXPERIMENT: 05061 TEST: 01                                                 PAGE  54
                  STATISTICAL ANALYSIS OF PRIMARY TUMORS IN FEMALE RATS(FISCHER344) -- 1-AMINO 2,4-DIBROMOANTHRAQUINONE
                       TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE                   |         UNTREATE           0.2%               0.5%               1.0%               2.0%                |
|                       |         D 71UF             71LF               71MLF              71MHF              FEMALE              |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: C-Cell                                                                                                            |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                                                                         |
|-----------            |                                                                                                         |
|OVERALL (a)            |        5/70 (7%)          5/50 (10%)         6/70 (9%)          1/59 (2%)          0/38 (0%)            |
|ADJUSTED (b)           |        13.2%              15.6%              15.2%               6.7%               0.0%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 2 (c)|        0/10 (0%)          0/0                0/0                0/0                0/20 (0%)            |
|TERMINAL (d)           |        5/38 (13%)         5/32 (16%)         5/38 (13%)         0/12 (0%)          0/0                  |
|FIRST INCIDENCE (DAYS) |         729 (T)            729 (T)            714                719                ---                 |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P=0.552N           P=0.519            P=0.503            P=0.509N             (e)                |
|INCIDENTAL TUMOR       |        P=0.399N           P=0.519            P=0.547            P=0.350N             (e)                |
|LOGISTIC REGRESSION    |        P=0.439N           P=0.519            P=0.530            P=0.421N             (e)                |
|COCHRAN-ARMITAGE       |        P=0.022N*                                                                                        |
|FISHER EXACT           |                           P=0.406            P=0.500            P=0.149N           P=0.109N             |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: Follicular Cell                                                                                                   |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                                                                         |
|-----------            |                                                                                                         |
|OVERALL (a)            |        0/70 (0%)          1/50 (2%)          1/70 (1%)          2/59 (3%)          0/38 (0%)            |
|ADJUSTED (b)           |         0.0%               3.1%               2.2%              12.0%               0.0%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 2 (c)|        0/10 (0%)          0/0                0/0                0/0                0/20 (0%)            |
|TERMINAL (d)           |        0/38 (0%)          1/32 (3%)          0/38 (0%)          1/12 (8%)          0/0                  |
|FIRST INCIDENCE (DAYS) |         ---                729 (T)            691                664                ---                 |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P=0.093            P=0.466            P=0.518            P=0.083              (e)                |
|INCIDENTAL TUMOR       |        P=0.259            P=0.466            P=0.652            P=0.184              (e)                |
|LOGISTIC REGRESSION    |        P=0.238            P=0.466            P=0.517            P=0.155              (e)                |
|COCHRAN-ARMITAGE       |        P=0.596                                                                                          |
|FISHER EXACT           |                           P=0.417            P=0.500            P=0.207              (e)                |
|=================================================================================================================================|
         DATE: 05/19/95                     EXPERIMENT: 05061 TEST: 01                                                 PAGE  55
                  STATISTICAL ANALYSIS OF PRIMARY TUMORS IN FEMALE RATS(FISCHER344) -- 1-AMINO 2,4-DIBROMOANTHRAQUINONE
                       TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE                   |         UNTREATE           0.2%               0.5%               1.0%               2.0%                |
|                       |         D 71UF             71LF               71MLF              71MHF              FEMALE              |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: Follicular Cell                                                                                                   |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                                                                         |
|-----------            |                                                                                                         |
|OVERALL (a)            |        0/70 (0%)          0/50 (0%)          0/70 (0%)          0/59 (0%)          0/38 (0%)            |
|ADJUSTED (b)           |         0.0%               0.0%               0.0%               0.0%               0.0%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 2 (c)|        0/10 (0%)          0/0                0/0                0/0                0/20 (0%)            |
|TERMINAL (d)           |        0/38 (0%)          0/32 (0%)          0/38 (0%)          0/12 (0%)          0/0                  |
|FIRST INCIDENCE (DAYS) |         ---                ---                ---                ---                ---                 |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |          (e)                (e)                (e)                (e)                (e)                |
|INCIDENTAL TUMOR       |          (e)                (e)                (e)                (e)                (e)                |
|LOGISTIC REGRESSION    |          (e)                (e)                (e)                (e)                (e)                |
|COCHRAN-ARMITAGE       |          (e)                                                                                            |
|FISHER EXACT           |                             (e)                (e)                (e)                (e)                |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: Follicular Cell                                                                                                   |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                                                                         |
|-----------            |                                                                                                         |
|OVERALL (a)            |        0/70 (0%)          1/50 (2%)          1/70 (1%)          2/59 (3%)          0/38 (0%)            |
|ADJUSTED (b)           |         0.0%               3.1%               2.2%              12.0%               0.0%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 2 (c)|        0/10 (0%)          0/0                0/0                0/0                0/20 (0%)            |
|TERMINAL (d)           |        0/38 (0%)          1/32 (3%)          0/38 (0%)          1/12 (8%)          0/0                  |
|FIRST INCIDENCE (DAYS) |         ---                729 (T)            691                664                ---                 |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P=0.093            P=0.466            P=0.518            P=0.083              (e)                |
|INCIDENTAL TUMOR       |        P=0.259            P=0.466            P=0.652            P=0.184              (e)                |
|LOGISTIC REGRESSION    |        P=0.238            P=0.466            P=0.517            P=0.155              (e)                |
|COCHRAN-ARMITAGE       |        P=0.596                                                                                          |
|FISHER EXACT           |                           P=0.417            P=0.500            P=0.207              (e)                |
|=================================================================================================================================|
         DATE: 05/19/95                     EXPERIMENT: 05061 TEST: 01                                                 PAGE  56
                  STATISTICAL ANALYSIS OF PRIMARY TUMORS IN FEMALE RATS(FISCHER344) -- 1-AMINO 2,4-DIBROMOANTHRAQUINONE
                       TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE                   |         UNTREATE           0.2%               0.5%               1.0%               2.0%                |
|                       |         D 71UF             71LF               71MLF              71MHF              FEMALE              |
|=================================================================================================================================|
|                                                                                                                                 |
|Tissue NOS                                                                                                                       |
|     Sarcoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |          #                  #                  #                  #                  #                  |
|-----------            |                                                                                                         |
|OVERALL (a)            |        2/70 (3%)          0/50 (0%)          0/70 (0%)          0/69 (0%)          0/38 (0%)            |
|ADJUSTED (b)           |         3.5%               0.0%               0.0%               0.0%               0.0%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 2 (c)|        0/10 (0%)          0/0                0/0                0/10 (0%)          0/20 (0%)            |
|TERMINAL (d)           |        0/38 (0%)          0/32 (0%)          0/38 (0%)          0/12 (0%)          0/0                  |
|FIRST INCIDENCE (DAYS) |         268                ---                ---                ---                ---                 |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P=0.227N           P=0.301N           P=0.221N           P=0.270N           P=0.622N             |
|INCIDENTAL TUMOR       |        P=0.039N*          P=0.557N           P=0.388N           P=0.227N           P=0.282N             |
|LOGISTIC REGRESSION    |        P=0.138N           P=0.317N           P=0.276N           P=0.217N           P=0.234N             |
|COCHRAN-ARMITAGE       |        P=0.191N                                                                                         |
|FISHER EXACT           |                           P=0.338N           P=0.248N           P=0.252N           P=0.418N             |
|=================================================================================================================================|
|                                                                                                                                 |
|Urinary Bladder                                                                                                                  |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                                                                         |
|-----------            |                                                                                                         |
|OVERALL (a)            |        0/70 (0%)          0/50 (0%)          8/70 (11%)        18/66 (27%)         6/38 (16%)           |
|ADJUSTED (b)           |         0.0%               0.0%              19.5%              57.2%              27.8%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 2 (c)|        0/10 (0%)          0/0                0/0                2/10 (20%)         5/20 (25%)           |
|TERMINAL (d)           |        0/38 (0%)          0/32 (0%)          6/38 (16%)         4/12 (33%)         0/0                  |
|FIRST INCIDENCE (DAYS) |         ---                ---                670                367                299                 |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P<0.001 **           (e)              P=0.006 **         P<0.001 **         P=0.044 *            |
|INCIDENTAL TUMOR       |        P<0.001 **           (e)              P=0.010 **         P<0.001 **         P=0.093              |
|LOGISTIC REGRESSION    |        P<0.001 **           (e)              P=0.008 **         P<0.001 **         P=0.009 **           |
|COCHRAN-ARMITAGE       |        P<0.001 **                                                                                       |
|FISHER EXACT           |                             (e)              P=0.003 **         P<0.001 **         P=0.001 **           |
|=================================================================================================================================|
         DATE: 05/19/95                     EXPERIMENT: 05061 TEST: 01                                                 PAGE  57
                  STATISTICAL ANALYSIS OF PRIMARY TUMORS IN FEMALE RATS(FISCHER344) -- 1-AMINO 2,4-DIBROMOANTHRAQUINONE
                       TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE                   |         UNTREATE           0.2%               0.5%               1.0%               2.0%                |
|                       |         D 71UF             71LF               71MLF              71MHF              FEMALE              |
|=================================================================================================================================|
|                                                                                                                                 |
|Urinary Bladder                                                                                                                  |
|     Papilloma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                                                                         |
|-----------            |                                                                                                         |
|OVERALL (a)            |        0/70 (0%)          2/50 (4%)          7/70 (10%)        10/66 (15%)         2/38 (5%)            |
|ADJUSTED (b)           |         0.0%               6.3%              17.6%              40.6%               8.8%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 2 (c)|        0/10 (0%)          0/0                0/0                1/10 (10%)         1/20 (5%)            |
|TERMINAL (d)           |        0/38 (0%)          2/32 (6%)          6/38 (16%)         1/12 (8%)          0/0                  |
|FIRST INCIDENCE (DAYS) |         ---                729 (T)            691                462 (I)            426                 |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P<0.001 **         P=0.201            P=0.010 *          P<0.001 **         P=0.207              |
|INCIDENTAL TUMOR       |        P=0.001 **         P=0.201            P=0.013 *          P=0.005 **         P=0.638              |
|LOGISTIC REGRESSION    |        P<0.001 **         P=0.201            P=0.012 *          P<0.001 **         P=0.198              |
|COCHRAN-ARMITAGE       |        P=0.075                                                                                          |
|FISHER EXACT           |                           P=0.172            P=0.007 **         P<0.001 **         P=0.122              |
|=================================================================================================================================|
|                                                                                                                                 |
|Urinary Bladder                                                                                                                  |
|     Squamous Cell Carcinoma                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                                                                         |
|-----------            |                                                                                                         |
|OVERALL (a)            |        0/70 (0%)          0/50 (0%)          1/70 (1%)          2/66 (3%)          0/38 (0%)            |
|ADJUSTED (b)           |         0.0%               0.0%               2.6%               3.6%               0.0%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 2 (c)|        0/10 (0%)          0/0                0/0                2/10 (20%)         0/20 (0%)            |
|TERMINAL (d)           |        0/38 (0%)          0/32 (0%)          1/38 (3%)          0/12 (0%)          0/0                  |
|FIRST INCIDENCE (DAYS) |         ---                ---                729 (T)            462 (I)            ---                 |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P=0.563N             (e)              P=0.500            P=0.234              (e)                |
|INCIDENTAL TUMOR       |        P=0.563N             (e)              P=0.500            P=0.234              (e)                |
|LOGISTIC REGRESSION    |        P=0.515              (e)              P=0.500            P=0.251              (e)                |
|COCHRAN-ARMITAGE       |        P=0.467                                                                                          |
|FISHER EXACT           |                             (e)              P=0.500            P=0.234              (e)                |
|=================================================================================================================================|
         DATE: 05/19/95                     EXPERIMENT: 05061 TEST: 01                                                 PAGE  58
                  STATISTICAL ANALYSIS OF PRIMARY TUMORS IN FEMALE RATS(FISCHER344) -- 1-AMINO 2,4-DIBROMOANTHRAQUINONE
                       TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE                   |         UNTREATE           0.2%               0.5%               1.0%               2.0%                |
|                       |         D 71UF             71LF               71MLF              71MHF              FEMALE              |
|=================================================================================================================================|
|                                                                                                                                 |
|Urinary Bladder                                                                                                                  |
|     Squamous Cell Papilloma                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                                                                         |
|-----------            |                                                                                                         |
|OVERALL (a)            |        0/70 (0%)          0/50 (0%)          1/70 (1%)          2/66 (3%)          0/38 (0%)            |
|ADJUSTED (b)           |         0.0%               0.0%               2.6%              12.2%               0.0%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 2 (c)|        0/10 (0%)          0/0                0/0                0/10 (0%)          0/20 (0%)            |
|TERMINAL (d)           |        0/38 (0%)          0/32 (0%)          1/38 (3%)          1/12 (8%)          0/0                  |
|FIRST INCIDENCE (DAYS) |         ---                ---                729 (T)            673                ---                 |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P=0.033 *            (e)              P=0.500            P=0.080              (e)                |
|INCIDENTAL TUMOR       |        P=0.072              (e)              P=0.500            P=0.175              (e)                |
|LOGISTIC REGRESSION    |        P=0.086              (e)              P=0.500            P=0.138              (e)                |
|COCHRAN-ARMITAGE       |        P=0.467                                                                                          |
|FISHER EXACT           |                             (e)              P=0.500            P=0.234              (e)                |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Polyp Stromal                                                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |          #                  #                  #                  #                  #                  |
|-----------            |                                                                                                         |
|OVERALL (a)            |        9/70 (13%)        15/50 (30%)         8/70 (11%)         6/69 (9%)          2/38 (5%)            |
|ADJUSTED (b)           |        21.6%              41.4%              17.8%              18.9%              10.0%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          1/10 (10%)         0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 2 (c)|        1/10 (10%)         0/0                0/0                1/10 (10%)         2/20 (10%)           |
|TERMINAL (d)           |        7/38 (18%)        11/32 (34%)         5/38 (13%)         0/12 (0%)          0/0                  |
|FIRST INCIDENCE (DAYS) |         462 (I)            600                279 (I)            462 (I)            462 (I)             |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P=0.500N           P=0.030 *          P=0.588N           P=0.402            P=0.737              |
|INCIDENTAL TUMOR       |        P=0.073N           P=0.023 *          P=0.500N           P=0.291N           P=0.737              |
|LOGISTIC REGRESSION    |        P=0.147N           P=0.026 *          P=0.445N           P=0.400N           P=0.602              |
|COCHRAN-ARMITAGE       |        P=0.015N*                                                                                        |
|FISHER EXACT           |                           P=0.019 *          P=0.500N           P=0.303N           P=0.182N             |
|=================================================================================================================================|
         DATE: 05/19/95                     EXPERIMENT: 05061 TEST: 01                                                 PAGE  59
                  STATISTICAL ANALYSIS OF PRIMARY TUMORS IN FEMALE RATS(FISCHER344) -- 1-AMINO 2,4-DIBROMOANTHRAQUINONE
                       TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE                   |         UNTREATE           0.2%               0.5%               1.0%               2.0%                |
|                       |         D 71UF             71LF               71MLF              71MHF              FEMALE              |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Sarcoma Stromal or Polyp Stromal                                                                                            |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |          #                  #                  #                  #                  #                  |
|-----------            |                                                                                                         |
|OVERALL (a)            |        9/70 (13%)        15/50 (30%)         9/70 (13%)         6/69 (9%)          2/38 (5%)            |
|ADJUSTED (b)           |        21.6%              41.4%              20.3%              18.9%              10.0%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          1/10 (10%)         0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 2 (c)|        1/10 (10%)         0/0                0/0                1/10 (10%)         2/20 (10%)           |
|TERMINAL (d)           |        7/38 (18%)        11/32 (34%)         6/38 (16%)         0/12 (0%)          0/0                  |
|FIRST INCIDENCE (DAYS) |         462 (I)            600                279 (I)            462 (I)            462 (I)             |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P=0.530N           P=0.030 *          P=0.517            P=0.402            P=0.737              |
|INCIDENTAL TUMOR       |        P=0.085N           P=0.023 *          P=0.604            P=0.291N           P=0.737              |
|LOGISTIC REGRESSION    |        P=0.158N           P=0.026 *          P=0.541N           P=0.400N           P=0.602              |
|COCHRAN-ARMITAGE       |        P=0.014N*                                                                                        |
|FISHER EXACT           |                           P=0.019 *          P=0.599N           P=0.303N           P=0.182N             |
|=================================================================================================================================|
|                                                                                                                                 |
|Zymbal's Gland                                                                                                                   |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |          #                  #                  #                  #                  #                  |
|-----------            |                                                                                                         |
|OVERALL (a)            |        0/70 (0%)          0/50 (0%)          2/70 (3%)          0/69 (0%)          0/38 (0%)            |
|ADJUSTED (b)           |         0.0%               0.0%               4.5%               0.0%               0.0%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 2 (c)|        0/10 (0%)          0/0                0/0                0/10 (0%)          0/20 (0%)            |
|TERMINAL (d)           |        0/38 (0%)          0/32 (0%)          1/38 (3%)          0/12 (0%)          0/0                  |
|FIRST INCIDENCE (DAYS) |         ---                ---                649                ---                ---                 |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P=0.661              (e)              P=0.256              (e)                (e)                |
|INCIDENTAL TUMOR       |        P=0.786              (e)              P=0.321              (e)                (e)                |
|LOGISTIC REGRESSION    |        P=0.762              (e)              P=0.256              (e)                (e)                |
|COCHRAN-ARMITAGE       |        P=0.598N                                                                                         |
|FISHER EXACT           |                             (e)              P=0.248              (e)                (e)                |
|=================================================================================================================================|
         DATE: 05/19/95                     EXPERIMENT: 05061 TEST: 01                                                 PAGE  60
                  STATISTICAL ANALYSIS OF PRIMARY TUMORS IN FEMALE RATS(FISCHER344) -- 1-AMINO 2,4-DIBROMOANTHRAQUINONE
                       TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE                   |         UNTREATE           0.2%               0.5%               1.0%               2.0%                |
|                       |         D 71UF             71LF               71MLF              71MHF              FEMALE              |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Leukemia: Lymphocytic, Monocytic, Mononuclear, or Undifferentiated                                                          |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |          #                  #                  #                  #                  #                  |
|-----------            |                                                                                                         |
|OVERALL (a)            |        9/70 (13%)         1/50 (2%)          5/70 (7%)          1/69 (1%)          0/38 (0%)            |
|ADJUSTED (b)           |        21.5%               3.0%              10.0%               3.7%               0.0%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 2 (c)|        0/10 (0%)          0/0                0/0                0/10 (0%)          0/20 (0%)            |
|TERMINAL (d)           |        6/38 (16%)         0/32 (0%)          1/38 (3%)          0/12 (0%)          0/0                  |
|FIRST INCIDENCE (DAYS) |         620                689                601                662                ---                 |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P=0.154N           P=0.026N*          P=0.177N           P=0.162N             (e)                |
|INCIDENTAL TUMOR       |        P=0.004N**         P=0.025N*          P=0.062N           P=0.016N*            (e)                |
|LOGISTIC REGRESSION    |        P=0.026N*          P=0.026N*          P=0.152N           P=0.039N*          P=0.732N             |
|COCHRAN-ARMITAGE       |        P=0.007N**                                                                                       |
|FISHER EXACT           |                           P=0.031N*          P=0.199N           P=0.009N**         P=0.017N*            |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Mesothelioma: Benign, Malignant, NOS                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |          #                  #                  #                  #                  #                  |
|-----------            |                                                                                                         |
|OVERALL (a)            |        0/70 (0%)          0/50 (0%)          0/70 (0%)          0/69 (0%)          0/38 (0%)            |
|ADJUSTED (b)           |         0.0%               0.0%               0.0%               0.0%               0.0%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)            |
|INTERIM SACRIFICE 2 (c)|        0/10 (0%)          0/0                0/0                0/10 (0%)          0/20 (0%)            |
|TERMINAL (d)           |        0/38 (0%)          0/32 (0%)          0/38 (0%)          0/12 (0%)          0/0                  |
|FIRST INCIDENCE (DAYS) |         ---                ---                ---                ---                ---                 |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |          (e)                (e)                (e)                (e)                (e)                |
|INCIDENTAL TUMOR       |          (e)                (e)                (e)                (e)                (e)                |
|LOGISTIC REGRESSION    |          (e)                (e)                (e)                (e)                (e)                |
|COCHRAN-ARMITAGE       |          (e)                                                                                            |
|FISHER EXACT           |                             (e)                (e)                (e)                (e)                |
|=================================================================================================================================|
         DATE: 05/19/95                     EXPERIMENT: 05061 TEST: 01                                                 PAGE  61
                  STATISTICAL ANALYSIS OF PRIMARY TUMORS IN FEMALE RATS(FISCHER344) -- 1-AMINO 2,4-DIBROMOANTHRAQUINONE
                       TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE                   |         UNTREATE           0.2%               0.5%               1.0%               2.0%                |
|                       |         D 71UF             71LF               71MLF              71MHF              FEMALE              |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Benign Tumors                                                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |          #                  #                  #                  #                  #                  |
|-----------            |                                                                                                         |
|OVERALL (a)            |       45/70 (64%)        40/50 (80%)        61/70 (87%)        54/69 (78%)        25/38 (66%)           |
|ADJUSTED (b)           |        91.8%             100.0%             100.0%             100.0%              92.3%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          1/10 (10%)         0/10 (0%)          3/10 (30%)           |
|INTERIM SACRIFICE 2 (c)|        2/10 (20%)         0/0                0/0                8/10 (80%)        18/20 (90%)           |
|TERMINAL (d)           |       34/38 (89%)        32/32 (100%)       38/38 (100%)       12/12 (100%)        0/0                  |
|FIRST INCIDENCE (DAYS) |         462 (I)            600                279 (I)            418                279 (I)             |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P<0.001 **         P=0.223            P=0.005 **         P<0.001 **         P<0.001 **           |
|INCIDENTAL TUMOR       |        P<0.001 **         P=0.030 *          P=0.005 **         P<0.001 **         P<0.001 **           |
|LOGISTIC REGRESSION    |        P=0.017 *          P=0.037 *          P=0.001 **         P=0.001 **         P=0.067              |
|COCHRAN-ARMITAGE       |        P=0.420N                                                                                         |
|FISHER EXACT           |                           P=0.047 *          P=0.001 **         P=0.051            P=0.524              |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant Tumors                                                                                                            |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |          #                  #                  #                  #                  #                  |
|-----------            |                                                                                                         |
|OVERALL (a)            |       16/70 (23%)        15/50 (30%)        60/70 (86%)        55/69 (80%)        23/38 (61%)           |
|ADJUSTED (b)           |        33.6%              45.5%             100.0%             100.0%              88.2%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          0/10 (0%)          0/10 (0%)          1/10 (10%)           |
|INTERIM SACRIFICE 2 (c)|        0/10 (0%)          0/0                0/0                9/10 (90%)        17/20 (85%)           |
|TERMINAL (d)           |        8/38 (21%)        14/32 (44%)        38/38 (100%)       12/12 (100%)        0/0                  |
|FIRST INCIDENCE (DAYS) |         268                689                575                367                279 (I)             |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P<0.001 **         P=0.420            P<0.001 **         P<0.001 **         P<0.001 **           |
|INCIDENTAL TUMOR       |        P<0.001 **         P=0.317            P<0.001 **         P<0.001 **         P<0.001 **           |
|LOGISTIC REGRESSION    |        P<0.001 **         P=0.317            P<0.001 **         P<0.001 **         P=0.013 *            |
|COCHRAN-ARMITAGE       |        P<0.001 **                                                                                       |
|FISHER EXACT           |                           P=0.251            P<0.001 **         P<0.001 **         P<0.001 **           |
|=================================================================================================================================|
         DATE: 05/19/95                     EXPERIMENT: 05061 TEST: 01                                                 PAGE  62
                  STATISTICAL ANALYSIS OF PRIMARY TUMORS IN FEMALE RATS(FISCHER344) -- 1-AMINO 2,4-DIBROMOANTHRAQUINONE
                       TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE                   |         UNTREATE           0.2%               0.5%               1.0%               2.0%                |
|                       |         D 71UF             71LF               71MLF              71MHF              FEMALE              |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant and Benign Tumors                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |          #                  #                  #                  #                  #                  |
|-----------            |                                                                                                         |
|OVERALL (a)            |       48/70 (69%)        40/50 (80%)        61/70 (87%)        58/69 (84%)        30/38 (79%)           |
|ADJUSTED (b)           |        92.2%             100.0%             100.0%             100.0%              96.7%                |
|INTERIM SACRIFICE 1 (c)|        0/10 (0%)          0/10 (0%)          1/10 (10%)         0/10 (0%)          4/10 (40%)           |
|INTERIM SACRIFICE 2 (c)|        2/10 (20%)         0/0                0/0                9/10 (90%)        19/20 (95%)           |
|TERMINAL (d)           |       34/38 (89%)        32/32 (100%)       38/38 (100%)       12/12 (100%)        0/0                  |
|FIRST INCIDENCE (DAYS) |         268                600                279 (I)            367                279 (I)             |
|-----------------------|                                                                                                         |
|STATISTICAL TESTS (f)  |                                                                                                         |
|-----------------------|                                                                                                         |
|LIFE TABLE             |        P<0.001 **         P=0.430            P=0.025 *          P<0.001 **         P<0.001 **           |
|INCIDENTAL TUMOR       |        P<0.001 **         P=0.086            P=0.035 *          P=0.002 **         P<0.001 **           |
|LOGISTIC REGRESSION    |        P=0.014 *          P=0.120            P=0.011 *          P=0.002 **         P=0.098              |
|COCHRAN-ARMITAGE       |        P=0.158                                                                                          |
|FISHER EXACT           |                           P=0.117            P=0.007 **         P=0.025 *          P=0.178              |
|=================================================================================================================================|
 (a)  Number of tumor-bearing animals / number of animals examined at site.
 (b)  Kaplan-Meier estimated lifetime tumor incidence after adjustment for 
      intercurrent mortality.
 (c)  Observed incidence at interim kill.
          Male interim sacrifices(days):   273  456
          Female interim sacrifices(days): 279  462
 (d)  Observed incidence at terminal kill.
 (f)  Beneath the control incidence are the P-values associated with the trend 
      test.  Beneath the dosed group incidence are the P-values corresponding to 
      pairwise comparisons between the controls and that dosed group.  The life
      table analysis regards tumors in animals dying  prior to terminal kill as
      being (directly or indirectly) the cause of death.  The incidental tumor 
      test regards these lesions as non-fatal.  Logistic regression is an alternative
      method for analyzing the incidence of non-fatal tumors.  The Cochran-Armitage
      and Fisher's exact tests compare directly the overall incidence rates.  
      For all tests, a negative trend is indicated by "N".
 (e)  Value of Statistic cannot be computed. 
 (I)  Interim sacrifice
 (T)  Terminal sacrifice
  #   Tumor rates based on number of animals necropsied.
  *   To the right of any statistical result, indicates significance at (P<=0.05).
  **  To the right of any statistical result, indicates significance at (P<=0.01).

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