National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/1756

TR 383 Rat Pathology Tables

NTP Experiment-Test: 05061-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97
Route: DOSED FEED                                                                                                 Time: 11:03:13




       Facility:  TSI Mason Research

       Chemical CAS #:  81-49-2

       Lock Date:  03/25/92

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All






































                                                              Page   1

NTP Experiment-Test: 05061-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 11:03:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 4| 2| 7| 7| 7| 4| 2| 7| 7| 7| 6| 2| 7| 7| 4| 2| 2| 7| 7| 7| 6| 4|             
                             DAY ON TEST   | 3| 3| 0| 6| 8| 3| 3| 3| 6| 8| 3| 3| 3| 0| 6| 3| 3| 6| 8| 8| 3| 3| 3| 7| 6|             
                                           | 4| 4| 1| 2| 1| 4| 4| 4| 2| 1| 5| 5| 5| 6| 8| 5| 5| 2| 1| 1| 6| 6| 6| 5| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    UNTREATE                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    D 71UF                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                        2                                 |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                        4                                 |             
      Parasite Metazoan                    |       1                    2              1     1              1  1      |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                        4                                 |             
      Parasite Metazoan                    |       2        1  1           2                             1            |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                        3                                 |             
      Parasite Metazoan                    | 1                 X                                1                     |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                        2                                 |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                        4                                 |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                        4                                 |             
      Ulcer                                |                               2                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     | 1  1  1  1     1  1  1  1     1  1  1  1     2  2  1     1     2  1      |             
      Clear Cell Focus                     |                      1                                                   |             
      Eosinophilic Focus                   | 2                 1     2           1           2                        |             
      Fatty Change                         |                                        2                             3   |             
      Hepatodiaphragmatic Nodule           |                                              X     X           X         |             
      Hepatodiaphragmatic Nodule, Multiple |                                                                   X      |             
      Infarct                              |                                                                          |             
      Inflammation, Chronic, Granulomatous |          2                                         1                    1|             
      Inflammation, Chronic Active         | 1              2        1  1     1              1           1  1         |             
      Mixed Cell Focus                     |                                                                          |             
      Necrosis, Coagulative                |                         1                                   1            |             
      Pigmentation                         |       1                                                                  |             
      Thrombosis                           |                                                                          |             
      Bile Duct, Hyperplasia               |    1  1           1  1  2     1  1           1     1        1     1  1   |             
      Centrilobular, Hemorrhage            |                                                                          |             
      Centrilobular, Necrosis, Coagulative |                                                                          |             
      Periportal, Inflammation, Chronic    |          1              1                          1                    1|             
      Periportal, Inflammation, Chronic    |                                                                          |             
          Active                           |    1  1     1        1     1  1  1              1           1  1  1      |             
                                            __________________________________________________________________________|             
   Mesentery                               |                +                                +              +         |             
      Fibrosis                             |                                                 1              2         |             
      Inflammation, Chronic Active         |                4                                1              3         |             
      Necrosis, Coagulative                |                                                                3         |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05061-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 11:03:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 4| 2| 7| 7| 7| 4| 2| 7| 7| 7| 6| 2| 7| 7| 4| 2| 2| 7| 7| 7| 6| 4|             
                             DAY ON TEST   | 3| 3| 0| 6| 8| 3| 3| 3| 6| 8| 3| 3| 3| 0| 6| 3| 3| 6| 8| 8| 3| 3| 3| 7| 6|             
                                           | 4| 4| 1| 2| 1| 4| 4| 4| 2| 1| 5| 5| 5| 6| 8| 5| 5| 2| 1| 1| 6| 6| 6| 5| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    UNTREATE                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    D 71UF                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Atrophy                              |                   1           1  1  1  1     1              1     1  1   |             
      Autolysis                            |                                        2                                 |             
      Ectopic Tissue                       |                                                                          |             
      Infiltration Cellular, Mononuclear   |                                                                          |             
          Cell                             |             1              1                                             |             
      Inflammation, Chronic                |          1              1                          1                    1|             
      Inflammation, Chronic Active         |    1           1  1  3        1  1  1  1  1  1  1           1     1  1   |             
      Vacuolization Cytoplasmic            |       1                                                                  |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Sublingual Gland, Inflammation,      |                                                                          |             
          Chronic Active                   |                               1                                          |             
      Submandibular Gland, Inflammation,   |                                                                          |             
           Chronic Active                  |                                        2                                 |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                        2                                 |             
      Hyperkeratosis                       |                                        2                                 |             
      Hyperplasia, Basal Cell              |                                        1                                 |             
      Hyperplasia, Squamous                |                                                                          |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                        2                                 |             
      Inflammation, Chronic Active         |                      2                                                   |             
      Necrosis, Coagulative                |                                                                          |             
      Muscularis, Mineralization           |                                                    1  2                  |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                      +   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1  1  1  1  1  2  1  1  1  1  2  2  2  2     2  1  1  1  1  1  1  1  1  1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Angiectasis                          | 2              2  1  1              1        2  2              1  1     1|             
      Autolysis                            |                                                                          |             
      Hyperplasia                          |                      1        2                                          |             
      Hypertrophy                          |                                                                3         |             
      Necrosis, Coagulative                |                                                                          |             
      Thrombosis, Multiple                 |                                                                          |             
      Vacuolization Cytoplasmic            | 1  1                                3  3                       3     2   |             
      Capsule, Fibrosis                    |                                                                          |             
      Capsule, Hyperplasia                 |                                                                          |             
      Capsule, Inflammation, Chronic       |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Autolysis                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05061-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 11:03:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 4| 2| 7| 7| 7| 4| 2| 7| 7| 7| 6| 2| 7| 7| 4| 2| 2| 7| 7| 7| 6| 4|             
                             DAY ON TEST   | 3| 3| 0| 6| 8| 3| 3| 3| 6| 8| 3| 3| 3| 0| 6| 3| 3| 6| 8| 8| 3| 3| 3| 7| 6|             
                                           | 4| 4| 1| 2| 1| 4| 4| 4| 2| 1| 5| 5| 5| 6| 8| 5| 5| 2| 1| 1| 6| 6| 6| 5| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    UNTREATE                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    D 71UF                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Hyperplasia                          | 1     1           1              2           2                 1         |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +        +  +  +        +  +  +  +  +  +  +           +  +  +  +   |             
      Autolysis                            |                                        2                                 |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Thrombosis                           |                                        4                                 |             
      Pars Distalis, Cyst                  | 1     1              2  1                          1     1     2  1     1|             
      Pars Distalis, Hemorrhage            |             1                                                            |             
      Pars Distalis, Hyperplasia           |                1  1  2              2                                    |             
      Pars Intermedia, Cyst                |                                                          1               |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                        2                                 |             
      Infiltration Cellular, Mononuclear   |                                                                          |             
          Cell                             |                                                                          |             
      Ultimobranchial Cyst                 |                                                                          |             
      C-Cell, Hyperplasia                  |          1                                                              1|             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                        +  +                              |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +|             
      Abscess                              |                                                 2                        |             
      Cyst                                 |                                  4                                       |             
      Infiltration Cellular, Mononuclear   |                                                                          |             
          Cell                             |                                                                          |             
      Inflammation, Chronic                |          1              2                          2                    1|             
      Inflammation, Chronic Active         | 2  1              1  1        1  3  1        3                 1  1  3   |             
      Duct, Metaplasia, Squamous           | 2                                                                        |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 | 4                 2                             2              2  2      |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Fibrosis                             |                                                                          |             
      Hydrometra                           |       4  1           3                                                   |             
      Inflammation, Acute                  |                                                                1         |             
      Endometrium, Hyperplasia             |                                                    1                 2   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                        2                                 |             
                                            __________________________________________________________________________|             
   Lymph Node                              |             M              M              +           M  M               |             
      Mediastinal, Hemorrhage              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05061-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 11:03:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 4| 2| 7| 7| 7| 4| 2| 7| 7| 7| 6| 2| 7| 7| 4| 2| 2| 7| 7| 7| 6| 4|             
                             DAY ON TEST   | 3| 3| 0| 6| 8| 3| 3| 3| 6| 8| 3| 3| 3| 0| 6| 3| 3| 6| 8| 8| 3| 3| 3| 7| 6|             
                                           | 4| 4| 1| 2| 1| 4| 4| 4| 2| 1| 5| 5| 5| 6| 8| 5| 5| 2| 1| 1| 6| 6| 6| 5| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    UNTREATE                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    D 71UF                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Mediastinal, Hyperplasia             |                                                                          |             
      Mediastinal, Infiltration Cellular,  |                                                                          |             
           Histiocyte                      |                                                                          |             
      Mediastinal, Pigmentation            |                                                                          |             
      Pancreatic, Hyperplasia              |                                                                          |             
      Pancreatic, Infiltration Cellular,   |                                                                          |             
           Histiocyte                      |                                           1                              |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  I  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |          1                 3                          2  3               |             
      Infiltration Cellular, Histiocyte    |                                           1                              |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Depletion Lymphoid                   |                                                                          |             
      Infiltration Cellular, Histiocyte    | 1  1  1  1  2  2  1  1  2  2  1  1  1     1  1  1  1  1  1  1  1  1  1  2|             
      Pigmentation                         |          1              1                          1                    1|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Depletion Lymphoid                   |                                        4  2                              |             
      Hyperplasia                          |                                                                          |             
      Infiltration Cellular, Histiocyte    |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  I  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +|             
      Congestion                           |                                                                          |             
      Cyst                                 |                         1                                                |             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Galactocele                          |                                                                          |             
      Hyperplasia                          | 2  3           2  2     2     2  2  3        2  3  2        2  3  3  2  1|             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                                          |             
      Inflammation, Chronic Active         |                                                                      1   |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Osteopetrosis                        |          2                                                               |             
      Sternum, Osteopetrosis               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydrocephalus                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05061-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 11:03:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 4| 2| 7| 7| 7| 4| 2| 7| 7| 7| 6| 2| 7| 7| 4| 2| 2| 7| 7| 7| 6| 4|             
                             DAY ON TEST   | 3| 3| 0| 6| 8| 3| 3| 3| 6| 8| 3| 3| 3| 0| 6| 3| 3| 6| 8| 8| 3| 3| 3| 7| 6|             
                                           | 4| 4| 1| 2| 1| 4| 4| 4| 2| 1| 5| 5| 5| 6| 8| 5| 5| 2| 1| 1| 6| 6| 6| 5| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    UNTREATE                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    D 71UF                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Autolysis                            |                                                                          |             
      Hemorrhage                           |          1                                                               |             
      Infiltration Cellular, Histiocyte    | 1  1     1           1  1     1  1  1  1     1     1        1  1  1  1  1|             
      Inflammation, Chronic Active         |                                                                          |             
      Alveolus, Mineralization             |                                                                          |             
      Artery, Mineralization               | 1  1        1        1  1  1        1  1     1  1     1  1  1  1         |             
      Bronchiole, Epithelium, Hyperplasia  |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                                                          |             
      Inflammation, Chronic Active         |                                                                   1      |             
      Metaplasia, Squamous                 |                                                                          |             
      Submucosa, Inflammation, Chronic     |          1                                                               |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                        3                                 |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |             M              M                          M  M               |             
                                            __________________________________________________________________________|             
   Eye                                     |    +              +              +                             +     +   |             
      Synechia                             |                                                                          |             
      Lens, Cataract                       |                                                                4         |             
      Retina, Degeneration                 |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
      Autolysis                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Hydronephrosis                       |       4                                2                                 |             
      Inflammation, Chronic                |                                                       1                  |             
      Mineralization                       |                            1                             1               |             
      Nephropathy                          | 2  1  1  1     2  2  2  2     2  2  2  2  1  2  3  1        2  2  2  1  2|             
      Pelvis, Inflammation, Chronic Active |                                                                          |             
      Renal Tubule, Hyperplasia            |                                                 3                        |             
      Renal Tubule, Inflammation, Acute    |                                                                          |             
      Renal Tubule, Mineralization         |                                                                          |             
      Renal Tubule, Regeneration           |                            1                             1               |             
      Transitional Epithelium, Hyperplasia |                                  1                 1              1  1   |             
      Transitional Epithelium,             |                                                                          |             
          Mineralization                   |                                                    1                     |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Hyperplasia, Lymphoid                | 1              1              1                                1         |             
      Inflammation, Chronic Active         |                                                                          |             
      Transitional Epithelium, Hyperplasia |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   6                                                               
NTP Experiment-Test: 05061-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 11:03:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 2| 7| 7| 6| 4| 2| 7| 7| 6| 6| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2|             
                             DAY ON TEST   | 3| 3| 3| 0| 7| 3| 3| 5| 6| 7| 3| 3| 5| 4| 8| 3| 3| 3| 3| 1| 3| 3| 3| 3| 8|             
                                           | 6| 6| 6| 4| 9| 6| 6| 6| 2| 9| 4| 1| 8| 2| 1| 4| 4| 5| 5| 9| 4| 4| 4| 5| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    UNTREATE                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    D 71UF                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                  2                                       |             
      Parasite Metazoan                    |       1                                      1  1                 1      |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                  2                                       |             
      Parasite Metazoan                    | 2                                         1                       1     1|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                  2                                       |             
      Parasite Metazoan                    |                                              1                           |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                     1                                    |             
      Basophilic Focus                     | 1  1  2        4  2  1  1     1        1     1  1  2  2  1  2     1  1   |             
      Clear Cell Focus                     |                   2                                                      |             
      Eosinophilic Focus                   |                         1     2                 1                        |             
      Fatty Change                         |          2                             2                 2               |             
      Hepatodiaphragmatic Nodule           |                   X                                                      |             
      Hepatodiaphragmatic Nodule, Multiple |                                                                          |             
      Infarct                              |                      4                                                   |             
      Inflammation, Chronic, Granulomatous |                                                                          |             
      Inflammation, Chronic Active         | 1  2                 1        1                    1     1     1  2  1  1|             
      Mixed Cell Focus                     |       3                                                                  |             
      Necrosis, Coagulative                | 1        2                                                               |             
      Pigmentation                         |                         1                                                |             
      Thrombosis                           |                                                                          |             
      Bile Duct, Hyperplasia               | 2        1  1  1  1     1     1  1  1           1  1  1  1  1     2  1   |             
      Centrilobular, Hemorrhage            |                                                                          |             
      Centrilobular, Necrosis, Coagulative |                                                                          |             
      Periportal, Inflammation, Chronic    |                         1                                                |             
      Periportal, Inflammation, Chronic    |                                                                          |             
          Active                           | 2  1        1     1        1  1     1     1           1     1     1  1  1|             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Fibrosis                             |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Necrosis, Coagulative                |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   7                                                               
NTP Experiment-Test: 05061-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 11:03:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 2| 7| 7| 6| 4| 2| 7| 7| 6| 6| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2|             
                             DAY ON TEST   | 3| 3| 3| 0| 7| 3| 3| 5| 6| 7| 3| 3| 5| 4| 8| 3| 3| 3| 3| 1| 3| 3| 3| 3| 8|             
                                           | 6| 6| 6| 4| 9| 6| 6| 6| 2| 9| 4| 1| 8| 2| 1| 4| 4| 5| 5| 9| 4| 4| 4| 5| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    UNTREATE                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    D 71UF                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Atrophy                              |    1        1  1                             1  2        1  1            |             
      Autolysis                            |                                                                          |             
      Ectopic Tissue                       |                                                    X                     |             
      Infiltration Cellular, Mononuclear   |                                                                          |             
          Cell                             |             1                                                            |             
      Inflammation, Chronic                |                         1                                                |             
      Inflammation, Chronic Active         |    1  1        1  1                          1  1  1  1  1  1            |             
      Vacuolization Cytoplasmic            |                                  2  1                                    |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Sublingual Gland, Inflammation,      |                                                                          |             
          Chronic Active                   |                                                                          |             
      Submandibular Gland, Inflammation,   |                                                                          |             
           Chronic Active                  |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Hyperkeratosis                       |                                                          2               |             
      Hyperplasia, Basal Cell              |                                                          1               |             
      Hyperplasia, Squamous                |                      2                                   2               |             
      Ulcer                                |          2                                                               |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Inflammation, Chronic Active         |          2                                   1                           |             
      Necrosis, Coagulative                |                                                                          |             
      Muscularis, Mineralization           |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1  2  1  1     2  2  1  1     2     1     1  1  1  1  1  1  1  2  1  1   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Angiectasis                          |                      2  1     2              1     2     1  1  1  1      |             
      Autolysis                            |                                                                          |             
      Hyperplasia                          |                3                                                         |             
      Hypertrophy                          |                                                                          |             
      Necrosis, Coagulative                |                                                                          |             
      Thrombosis, Multiple                 |                                                                          |             
      Vacuolization Cytoplasmic            |          3                             1           2  1  1  1            |             
      Capsule, Fibrosis                    |                                           1                              |             
      Capsule, Hyperplasia                 |                               1                                          |             
      Capsule, Inflammation, Chronic       |                                           1                              |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Autolysis                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   8                                                               
NTP Experiment-Test: 05061-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 11:03:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 2| 7| 7| 6| 4| 2| 7| 7| 6| 6| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2|             
                             DAY ON TEST   | 3| 3| 3| 0| 7| 3| 3| 5| 6| 7| 3| 3| 5| 4| 8| 3| 3| 3| 3| 1| 3| 3| 3| 3| 8|             
                                           | 6| 6| 6| 4| 9| 6| 6| 6| 2| 9| 4| 1| 8| 2| 1| 4| 4| 5| 5| 9| 4| 4| 4| 5| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    UNTREATE                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    D 71UF                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Hyperplasia                          |    1              2                    2     1                           |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +     +  +  +        +  +  +  +     +  +  +  +  +  +  +  +  +   |             
      Autolysis                            |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  M  +  M  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Thrombosis                           |                                                                          |             
      Pars Distalis, Cyst                  |             1  1     2  1     1        2           1  2     1            |             
      Pars Distalis, Hemorrhage            |                                                                          |             
      Pars Distalis, Hyperplasia           |          2           2           1        2        2        1     1      |             
      Pars Intermedia, Cyst                |                         1                                                |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Infiltration Cellular, Mononuclear   |                                                                          |             
          Cell                             |                                                                          |             
      Ultimobranchial Cyst                 |                2                                                         |             
      C-Cell, Hyperplasia                  | 1                    1                             1  1  1           1   |             
      Follicular Cell, Hyperplasia         |                                        1                                 |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                                   3      |             
      Cyst                                 |                                                                          |             
      Infiltration Cellular, Mononuclear   |                                                                          |             
          Cell                             |                                                                          |             
      Inflammation, Chronic                |             2           1                 1                              |             
      Inflammation, Chronic Active         | 1  1        2  2  1  2        1     1        2  1     1  1     3  1  1  1|             
      Duct, Metaplasia, Squamous           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                              2              2            |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                              1                           |             
      Fibrosis                             |                2                                3                 3      |             
      Hydrometra                           |                                                    1                     |             
      Inflammation, Acute                  |                                                                          |             
      Endometrium, Hyperplasia             |                                                 1           1            |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +        M              M              +                             +|             
      Mediastinal, Hemorrhage              |                                           1                             2|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   9                                                               
NTP Experiment-Test: 05061-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 11:03:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 2| 7| 7| 6| 4| 2| 7| 7| 6| 6| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2|             
                             DAY ON TEST   | 3| 3| 3| 0| 7| 3| 3| 5| 6| 7| 3| 3| 5| 4| 8| 3| 3| 3| 3| 1| 3| 3| 3| 3| 8|             
                                           | 6| 6| 6| 4| 9| 6| 6| 6| 2| 9| 4| 1| 8| 2| 1| 4| 4| 5| 5| 9| 4| 4| 4| 5| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    UNTREATE                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    D 71UF                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Mediastinal, Hyperplasia             |    2                                                                     |             
      Mediastinal, Infiltration Cellular,  |                                                                          |             
           Histiocyte                      |    1                                                                     |             
      Mediastinal, Pigmentation            |                                                                          |             
      Pancreatic, Hyperplasia              | 2  2                                                                     |             
      Pancreatic, Infiltration Cellular,   |                                                                          |             
           Histiocyte                      | 1  1                                                                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                           2                             4|             
      Infiltration Cellular, Histiocyte    |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Depletion Lymphoid                   |                                        3                                 |             
      Infiltration Cellular, Histiocyte    | 1  1  1  2  2  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1|             
      Pigmentation                         |                         1                                                |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Depletion Lymphoid                   |                                  4     3                                 |             
      Hyperplasia                          |    3                                                                     |             
      Infiltration Cellular, Histiocyte    |    3                                                                     |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Cyst                                 |                                                                          |             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Galactocele                          |                                                                          |             
      Hyperplasia                          | 4  2  2  2     2     2           2  3  2     2        2  2  2  2  3  1   |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                                          |             
      Inflammation, Chronic Active         |                               3                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Osteopetrosis                        |                                                                          |             
      Sternum, Osteopetrosis               |                                                       4                  |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydrocephalus                        |                                                          1               |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  10                                                               
NTP Experiment-Test: 05061-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 11:03:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 2| 7| 7| 6| 4| 2| 7| 7| 6| 6| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2|             
                             DAY ON TEST   | 3| 3| 3| 0| 7| 3| 3| 5| 6| 7| 3| 3| 5| 4| 8| 3| 3| 3| 3| 1| 3| 3| 3| 3| 8|             
                                           | 6| 6| 6| 4| 9| 6| 6| 6| 2| 9| 4| 1| 8| 2| 1| 4| 4| 5| 5| 9| 4| 4| 4| 5| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    UNTREATE                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    D 71UF                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Autolysis                            |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Infiltration Cellular, Histiocyte    | 1  1  1     1                       1           1     1  1  1        1   |             
      Inflammation, Chronic Active         |                      2                          3              1         |             
      Alveolus, Mineralization             |                                                                          |             
      Artery, Mineralization               |                   1           1        1                 1     1  1      |             
      Bronchiole, Epithelium, Hyperplasia  |                      2                                                   |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                      2                                                   |             
      Inflammation, Chronic Active         |                   1  3              1        2     2  2                  |             
      Metaplasia, Squamous                 |                                                    1                     |             
      Submucosa, Inflammation, Chronic     |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |             M              M                                            M|             
                                            __________________________________________________________________________|             
   Eye                                     |                      +           +        M  +        +  +  +            |             
      Synechia                             |                                                                          |             
      Lens, Cataract                       |                                                                          |             
      Retina, Degeneration                 |                                                       2                  |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                        +                                 |             
      Autolysis                            |                                        3                                 |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Hydronephrosis                       |                            2                                             |             
      Inflammation, Chronic                |                                                                         1|             
      Mineralization                       |                                                                          |             
      Nephropathy                          | 3  1  1  2     2  2  3  3     2  3  2  2     3  2  2  1  2  1  1  2  3   |             
      Pelvis, Inflammation, Chronic Active |                                              3                           |             
      Renal Tubule, Hyperplasia            |                                                                          |             
      Renal Tubule, Inflammation, Acute    |                                                                          |             
      Renal Tubule, Mineralization         |                                                                          |             
      Renal Tubule, Regeneration           |                                                                         1|             
      Transitional Epithelium, Hyperplasia |                         1        1           2  1              2         |             
      Transitional Epithelium,             |                                                                          |             
          Mineralization                   |                            1                                             |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Hyperplasia, Lymphoid                |    2  1        2  1                                      1           1   |             
      Inflammation, Chronic Active         |                                              1                           |             
      Transitional Epithelium, Hyperplasia |                      1                                                   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  11                                                               
NTP Experiment-Test: 05061-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 11:03:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 4| 4| 2| 7| 7| 6| 4| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 2|              |            |
                             DAY ON TEST   | 3| 0| 6| 6| 8| 3| 3| 2| 6| 6| 3| 3| 3| 1| 6| 3| 3| 3| 3| 7|              |            |
                                           | 4| 8| 2| 2| 1| 6| 5| 0| 4| 2| 6| 6| 6| 6| 2| 6| 6| 5| 5| 9|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|              |      A     |
    UNTREATE                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|              |      L     |
    D 71UF                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Autolysis                            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +               |  69        |
      Autolysis                            |                      2                                                   |      3  2.7|
      Parasite Metazoan                    |    1              1        2  2  1        1     1                        |     18  1.2|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  69        |
      Autolysis                            |                      1                 3                                 |      4  2.5|
      Parasite Metazoan                    | 2                             2  1                                       |     12  1.4|
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Autolysis                            |                      3                 3                                 |      4  2.8|
      Parasite Metazoan                    |                         1                       1                        |      6  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Autolysis                            |                                        3                                 |      2  2.5|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  68        |
      Autolysis                            |                      2                 4                                 |      3  3.3|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  69        |
      Autolysis                            |                      2                 3                                 |      3  3.0|
      Ulcer                                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Angiectasis                          |                                                                          |      1  1.0|
      Basophilic Focus                     | 1     1        2  2     1  1  1  1  1     1  1  1  1                     |     48  1.3|
      Clear Cell Focus                     |                                                    1                     |      3  1.3|
      Eosinophilic Focus                   |                               1                                          |      9  1.4|
      Fatty Change                         |                   1  2                 1                                 |      8  1.9|
      Hepatodiaphragmatic Nodule           |                         X     X     X  X           X  X                  |     10     |
      Hepatodiaphragmatic Nodule, Multiple |                                                                          |      1     |
      Infarct                              |                                                                          |      1  4.0|
      Inflammation, Chronic, Granulomatous |       1                 1                 1                              |      6  1.2|
      Inflammation, Chronic Active         |                1              1  1           1     1  1                  |     24  1.1|
      Mixed Cell Focus                     |                                                                          |      1  3.0|
      Necrosis, Coagulative                |                                                                          |      4  1.3|
      Pigmentation                         |                                                                          |      2  1.0|
      Thrombosis                           |    4                                                                     |      1  4.0|
      Bile Duct, Hyperplasia               |          1     1     2  1  1  1  1  1  1  1     1  1  1                  |     41  1.1|
      Centrilobular, Hemorrhage            |    3                                                                     |      1  3.0|
      Centrilobular, Necrosis, Coagulative |    3                                                                     |      1  3.0|
      Periportal, Inflammation, Chronic    |       1  1              1  1              1                              |     10  1.0|
      Periportal, Inflammation, Chronic    |                                                                          |            |
          Active                           | 1  1                          1  1  1           1     1                  |     31  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  12                                                               
NTP Experiment-Test: 05061-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 11:03:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 4| 4| 2| 7| 7| 6| 4| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 2|              |            |
                             DAY ON TEST   | 3| 0| 6| 6| 8| 3| 3| 2| 6| 6| 3| 3| 3| 1| 6| 3| 3| 3| 3| 7|              |            |
                                           | 4| 8| 2| 2| 1| 6| 5| 0| 4| 2| 6| 6| 6| 6| 2| 6| 6| 5| 5| 9|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|              |      A     |
    UNTREATE                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|              |      L     |
    D 71UF                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                      +                                                   |   4        |
      Fibrosis                             |                                                                          |      2  1.5|
      Inflammation, Chronic Active         |                                                                          |      3  2.7|
      Necrosis, Coagulative                |                      3                                                   |      2  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Atrophy                              | 3     2              2                       1  1     2                  |     22  1.3|
      Autolysis                            |                                                                          |      1  2.0|
      Ectopic Tissue                       |                         1                                                |      2  1.0|
      Infiltration Cellular, Mononuclear   |                                                                          |            |
          Cell                             |                                                                          |      3  1.0|
      Inflammation, Chronic                |       1                 1  1              1                              |      9  1.0|
      Inflammation, Chronic Active         | 2  1                                         1  1     1                  |     29  1.1|
      Vacuolization Cytoplasmic            |                                        1     1                           |      5  1.2|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Sublingual Gland, Inflammation,      |                                                                          |            |
          Chronic Active                   |                                                                          |      1  1.0|
      Submandibular Gland, Inflammation,   |                                                                          |            |
           Chronic Active                  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +               |  69        |
      Autolysis                            |                                                                          |      1  2.0|
      Hyperkeratosis                       |                                                                          |      2  2.0|
      Hyperplasia, Basal Cell              |                                                                          |      2  1.0|
      Hyperplasia, Squamous                |                                                                          |      2  2.0|
      Ulcer                                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Autolysis                            |                                        3                                 |      2  2.5|
      Inflammation, Chronic Active         |                                                                          |      3  1.7|
      Necrosis, Coagulative                |    1                                                                     |      1  1.0|
      Muscularis, Mineralization           |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Cardiomyopathy                       | 1  1  1  1  1  1  1  2  1  1  1  2  1  2  1     2  1  2  1               |     63  1.3|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +               |  67        |
      Angiectasis                          | 1     1        2  1     2  1  1  2  2        1  1                        |     30  1.4|
      Autolysis                            |                                        2                                 |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  13                                                               
NTP Experiment-Test: 05061-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 11:03:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 4| 4| 2| 7| 7| 6| 4| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 2|              |            |
                             DAY ON TEST   | 3| 0| 6| 6| 8| 3| 3| 2| 6| 6| 3| 3| 3| 1| 6| 3| 3| 3| 3| 7|              |            |
                                           | 4| 8| 2| 2| 1| 6| 5| 0| 4| 2| 6| 6| 6| 6| 2| 6| 6| 5| 5| 9|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|              |      A     |
    UNTREATE                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|              |      L     |
    D 71UF                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia                          |                                                                          |      3  2.0|
      Hypertrophy                          |                                                                          |      1  3.0|
      Necrosis, Coagulative                |    3                                                                     |      1  3.0|
      Thrombosis, Multiple                 |    2                                                                     |      1  2.0|
      Vacuolization Cytoplasmic            |    2           1  3  1                       3                           |     17  1.9|
      Capsule, Fibrosis                    |                                                                          |      1  1.0|
      Capsule, Hyperplasia                 |                                                                          |      1  1.0|
      Capsule, Inflammation, Chronic       |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +               |  67        |
      Autolysis                            |                                        2                                 |      1  2.0|
      Hyperplasia                          |    3                                                                     |     11  1.5|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +           +  +  +        +  +  +  +     +  +  +  +                  |  50        |
      Autolysis                            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +               |  63        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Thrombosis                           |                                                                          |      1  4.0|
      Pars Distalis, Cyst                  |    1     1              1  1  1           1                              |     24  1.2|
      Pars Distalis, Hemorrhage            |                                                                          |      1  1.0|
      Pars Distalis, Hyperplasia           |                            2  1     2                                    |     14  1.6|
      Pars Intermedia, Cyst                |       1                 1                                                |      4  1.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Autolysis                            |                                        2                                 |      2  2.0|
      Infiltration Cellular, Mononuclear   |                                                                          |            |
          Cell                             |                                                          1               |      1  1.0|
      Ultimobranchial Cyst                 |                                                                          |      1  2.0|
      C-Cell, Hyperplasia                  |       1                    1     2                                       |     11  1.1|
      Follicular Cell, Hyperplasia         |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +               |  65        |
      Abscess                              |                                                                          |      2  2.5|
      Cyst                                 |                                                                          |      1  4.0|
      Infiltration Cellular, Mononuclear   |                                                                          |            |
          Cell                             |             1                                                            |      1  1.0|
      Inflammation, Chronic                |       1                                   1              1               |     10  1.3|
      Inflammation, Chronic Active         |                1  1  1     1     1  2        1  1  1  1                  |     37  1.4|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  14                                                               
NTP Experiment-Test: 05061-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 11:03:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 4| 4| 2| 7| 7| 6| 4| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 2|              |            |
                             DAY ON TEST   | 3| 0| 6| 6| 8| 3| 3| 2| 6| 6| 3| 3| 3| 1| 6| 3| 3| 3| 3| 7|              |            |
                                           | 4| 8| 2| 2| 1| 6| 5| 0| 4| 2| 6| 6| 6| 6| 2| 6| 6| 5| 5| 9|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|              |      A     |
    UNTREATE                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|              |      L     |
    D 71UF                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Duct, Metaplasia, Squamous           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Cyst                                 |                1                                1  1  1                  |     11  1.8|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Cyst                                 |                                                                          |      1  1.0|
      Fibrosis                             |                                                                          |      3  2.7|
      Hydrometra                           | 3                       2           2                    1               |      8  2.1|
      Inflammation, Acute                  |                                                                          |      1  1.0|
      Endometrium, Hyperplasia             |    2                                                                     |      5  1.4|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Autolysis                            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |             +                             +              M               |   7        |
      Mediastinal, Hemorrhage              |             1                             1                              |      4  1.3|
      Mediastinal, Hyperplasia             |                                                                          |      1  2.0|
      Mediastinal, Infiltration Cellular,  |                                                                          |            |
           Histiocyte                      |                                                                          |      1  1.0|
      Mediastinal, Pigmentation            |                                           1                              |      1  1.0|
      Pancreatic, Hyperplasia              |                                                                          |      2  2.0|
      Pancreatic, Infiltration Cellular,   |                                                                          |            |
           Histiocyte                      |                                                                          |      3  1.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  +               |  66        |
      Hemorrhage                           |             1                                            1               |      8  2.1|
      Infiltration Cellular, Histiocyte    |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Autolysis                            |                                        2                                 |      1  2.0|
      Depletion Lymphoid                   |    2                                                                     |      2  2.5|
      Infiltration Cellular, Histiocyte    | 1  1  1  1  1  1  1  1  1  2  1  1  1  1  2  1  1  1  1  1               |     69  1.1|
      Pigmentation                         |       1  1              1  1              1                              |     10  1.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Depletion Lymphoid                   |                   3  3                 3     2                           |      8  3.0|
      Hyperplasia                          |                                                                          |      1  3.0|
      Infiltration Cellular, Histiocyte    |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +               |  62        |
      Congestion                           |                                                          2               |      1  2.0|
      Cyst                                 |                                                                          |      1  1.0|
      Hemorrhage                           |             2                                                            |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  15                                                               
NTP Experiment-Test: 05061-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 11:03:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 4| 4| 2| 7| 7| 6| 4| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 2|              |            |
                             DAY ON TEST   | 3| 0| 6| 6| 8| 3| 3| 2| 6| 6| 3| 3| 3| 1| 6| 3| 3| 3| 3| 7|              |            |
                                           | 4| 8| 2| 2| 1| 6| 5| 0| 4| 2| 6| 6| 6| 6| 2| 6| 6| 5| 5| 9|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|              |      A     |
    UNTREATE                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|              |      L     |
    D 71UF                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +               |  65        |
      Galactocele                          |                      1                                                   |      1  1.0|
      Hyperplasia                          | 2  3  2        2  2  2  2  2     1  2  2     3  2  3  1                  |     47  2.2|
      Inflammation, Chronic Active         |    3                                                                     |      1  3.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Abscess                              |                                     3                                    |      1  3.0|
      Inflammation, Chronic Active         |                                                                          |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Osteopetrosis                        |                                                                          |      1  2.0|
      Sternum, Osteopetrosis               |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Hydrocephalus                        |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Autolysis                            |                                        2                                 |      1  2.0|
      Hemorrhage                           |                                                                          |      1  1.0|
      Infiltration Cellular, Histiocyte    |          1     1  1  1           1  1  3  1  1  1  1  1                  |     38  1.1|
      Inflammation, Chronic Active         |                                              2                           |      4  2.0|
      Alveolus, Mineralization             |                                           1                              |      1  1.0|
      Artery, Mineralization               |    1  1  1     1     1     1  1     1        1  1     1                  |     31  1.0|
      Bronchiole, Epithelium, Hyperplasia  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Foreign Body                         |                                                                          |      1  2.0|
      Inflammation, Chronic Active         |                   3                                   1                  |      9  1.8|
      Metaplasia, Squamous                 |                                                                          |      1  1.0|
      Submucosa, Inflammation, Chronic     |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Autolysis                            |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |             M                                            M               |            |
                                            __________________________________________________________________________|____________|
   Eye                                     | +  +                                                                     |  13        |
      Synechia                             |    2                                                                     |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  16                                                               
NTP Experiment-Test: 05061-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 11:03:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 4| 4| 2| 7| 7| 6| 4| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 2|              |            |
                             DAY ON TEST   | 3| 0| 6| 6| 8| 3| 3| 2| 6| 6| 3| 3| 3| 1| 6| 3| 3| 3| 3| 7|              |            |
                                           | 4| 8| 2| 2| 1| 6| 5| 0| 4| 2| 6| 6| 6| 6| 2| 6| 6| 5| 5| 9|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|              |      A     |
    UNTREATE                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|              |      L     |
    D 71UF                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Lens, Cataract                       |                                                                          |      1  4.0|
      Retina, Degeneration                 |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
      Autolysis                            |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Autolysis                            |                      2                 3                                 |      2  2.5|
      Hydronephrosis                       |                                                                          |      3  2.7|
      Inflammation, Chronic                |             1                                            1               |      4  1.0|
      Mineralization                       |                                                          1               |      3  1.0|
      Nephropathy                          | 3  1  1  3     2  2  2  1  2  1  2  1  1  1  2  2  2  2                  |     60  1.9|
      Pelvis, Inflammation, Chronic Active |                                                                          |      1  3.0|
      Renal Tubule, Hyperplasia            |                                                                          |      1  3.0|
      Renal Tubule, Inflammation, Acute    |                                  1                                       |      1  1.0|
      Renal Tubule, Mineralization         |                                           1                              |      1  1.0|
      Renal Tubule, Regeneration           |                                                          1               |      4  1.0|
      Transitional Epithelium, Hyperplasia | 1                    1                    1  1                           |     13  1.2|
      Transitional Epithelium,             |                                                                          |            |
          Mineralization                   |                            1                                             |      3  1.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Autolysis                            |                                        3                                 |      1  3.0|
      Hyperplasia, Lymphoid                |    1              1  1                          1     1                  |     15  1.1|
      Inflammation, Chronic Active         |                                                                          |      1  1.0|
      Transitional Epithelium, Hyperplasia |                                                                          |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  17                                                               
NTP Experiment-Test: 05061-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 11:03:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 2| 7| 7| 7| 6| 2| 7| 7| 7| 2| 2| 7| 7| 7| 7| 6| 7| 6| 6| 2| 2|             
                             DAY ON TEST   | 3| 3| 1| 0| 8| 3| 3| 3| 1| 8| 3| 3| 3| 8| 8| 3| 3| 3| 3| 5| 3| 8| 6| 8| 8|             
                                           | 4| 4| 6| 0| 1| 4| 4| 4| 1| 1| 4| 4| 4| 1| 1| 4| 4| 0| 0| 9| 4| 9| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0.2%                                   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    71LF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |       1  2              2  1                    1        1           1   |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atypia Cellular                      |                1                                                         |             
      Fibrosis                             |                                                                          |             
      Parasite Metazoan                    |          2                                                               |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Parasite Metazoan                    | 1                       2                          1                     |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Parasite Metazoan                    |                         1                                                |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                   1      |             
      Basophilic Focus                     | 1     1  2     1                 1                                       |             
      Clear Cell Focus                     | 1  1           2  1  2  1     1  2  1        1  2  1  1     2            |             
      Eosinophilic Focus                   |       2  2     1  4  1  3     2  1  1        2  1     2  1  2            |             
      Hepatodiaphragmatic Nodule           |                                                       X                  |             
      Hyperplasia, Focal                   |                                                                          |             
      Inflammation, Chronic Active         | 1  2           1  1                 2        1  1        1  2            |             
      Mixed Cell Focus                     | 2  4                 1           2                                       |             
      Necrosis, Coagulative                |                1                                1                        |             
      Pigmentation                         |          1     1  1  1  1        1  1  1        1                 1     1|             
      Bile Duct, Hyperplasia               |       1  1  1                             1                          1   |             
      Periportal, Inflammation, Chronic    |                                                                          |             
          Active                           |       1  1  1              1           1  1                          1  1|             
                                            __________________________________________________________________________|             
   Mesentery                               |             M  +           M           M  M                          M  M|             
      Fibrosis                             |                2                                                         |             
      Inflammation, Chronic Active         |                2                                                         |             
      Necrosis, Coagulative                |                3                                                         |             
      Polyarteritis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 1              2  2           1              2     2     1        2  1   |             
      Cytoplasmic Alteration               |                                                          2               |             
      Ectopic Tissue                       |             1                                                            |             
      Infiltration Cellular, Mononuclear   |                                                                          |             
          Cell                             |                            1              1                          1  1|             
      Inflammation, Chronic Active         | 1        2     1  1           1     1        1     1     1        1      |             
      Polyarteritis                        | 4                                                                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  18                                                               
NTP Experiment-Test: 05061-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 11:03:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 2| 7| 7| 7| 6| 2| 7| 7| 7| 2| 2| 7| 7| 7| 7| 6| 7| 6| 6| 2| 2|             
                             DAY ON TEST   | 3| 3| 1| 0| 8| 3| 3| 3| 1| 8| 3| 3| 3| 8| 8| 3| 3| 3| 3| 5| 3| 8| 6| 8| 8|             
                                           | 4| 4| 6| 0| 1| 4| 4| 4| 1| 1| 4| 4| 4| 1| 1| 4| 4| 0| 0| 9| 4| 9| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0.2%                                   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    71LF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                                       +                  |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |          1              2                             2                  |             
      Hyperplasia, Basal Cell              |          1              2                             3                  |             
      Hyperplasia, Squamous                |          2              2                             3                  |             
      Inflammation, Chronic Active         |                         2                                                |             
      Ulcer                                |          3                                            2                  |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                         1                                                |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Cyst                                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1  1     1  2  1  1  1  1  1  2  1  2  1  1  1  2  2  1  1  1  1     1  1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 1  1        1  2  1  2           2  2  1  1  2  2        1  2     2      |             
      Hyperplasia                          | 1                                1  1                                    |             
      Vacuolization Cytoplasmic            | 1  1              1  1  2     1     1              1  1  1               |             
      Zona Reticularis, Hyperplasia        |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |          1        2           2                       1                  |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +  +  +  +  +      |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |          3              2                                                |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                                           1                             1|             
      Pars Distalis, Cyst                  |    1        1                 1  2           2        1  1        1      |             
      Pars Distalis, Hyperplasia           |    1              2           1  1  1     1           1  2               |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                1                                                         |             
      C-Cell, Hyperplasia                  |                                     1                                    |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                   +                                                      |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |       1                                                                  |             
      Hyperplasia                          |                      2                                                   |             
      Inflammation, Chronic Active         |    1  1  2        1     1     1  1  1        1           1  1        1   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  19                                                               
NTP Experiment-Test: 05061-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 11:03:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 2| 7| 7| 7| 6| 2| 7| 7| 7| 2| 2| 7| 7| 7| 7| 6| 7| 6| 6| 2| 2|             
                             DAY ON TEST   | 3| 3| 1| 0| 8| 3| 3| 3| 1| 8| 3| 3| 3| 8| 8| 3| 3| 3| 3| 5| 3| 8| 6| 8| 8|             
                                           | 4| 4| 6| 0| 1| 4| 4| 4| 1| 1| 4| 4| 4| 1| 1| 4| 4| 0| 0| 9| 4| 9| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0.2%                                   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    71LF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                4           2                                2            |             
      Pigmentation                         |                                                                          |             
      Periovarian Tissue, Cyst             |                            2              2                             2|             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                              2        3                  |             
      Cyst                                 |                                                                   3      |             
      Hydrometra                           |             1                          1           3                     |             
      Endometrium, Hyperplasia             | 2                    2              1                    1               |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Myelofibrosis                        |          2                                                               |             
                                            __________________________________________________________________________|             
   Lymph Node                              |             +  +           +        +  +  +                 +            |             
      Mediastinal, Hemorrhage              |                                           1                              |             
      Mediastinal, Infiltration Cellular,  |                                                                          |             
           Histiocyte                      |                                           1                              |             
      Mediastinal, Pigmentation            |                                                                          |             
      Pancreatic, Depletion Lymphoid       |             2                                                            |             
      Pancreatic, Hemorrhage               |             2              1                                             |             
      Pancreatic, Infiltration Cellular,   |                                                                          |             
           Histiocyte                      |             2  2                    1  1                    2            |             
      Pancreatic, Pigmentation             |                            1           1                                 |             
      Renal, Hemorrhage                    |                            1                                             |             
      Renal, Infiltration Cellular,        |                                                                          |             
          Histiocyte                       |                3                                                         |             
      Renal, Pigmentation                  |                            2                                             |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                            1              1                              |             
      Hyperplasia                          |                                                                   2      |             
      Infiltration Cellular, Histiocyte    |                                                                      1   |             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Depletion Lymphoid                   |          3                                                               |             
      Hemorrhage                           |             1              1                                             |             
      Infiltration Cellular, Histiocyte    | 1  1  1  1  1  1  1  2  1  2  1  1  1  1  1  1  1  1  1  1  1  1  1  1  2|             
      Pigmentation                         |                            1              1                          1  1|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Depletion Lymphoid                   |                                                                          |             
      Fibrosis                             |                               1                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  M  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  M  +  +|             
      Cyst                                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  20                                                               
NTP Experiment-Test: 05061-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 11:03:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 2| 7| 7| 7| 6| 2| 7| 7| 7| 2| 2| 7| 7| 7| 7| 6| 7| 6| 6| 2| 2|             
                             DAY ON TEST   | 3| 3| 1| 0| 8| 3| 3| 3| 1| 8| 3| 3| 3| 8| 8| 3| 3| 3| 3| 5| 3| 8| 6| 8| 8|             
                                           | 4| 4| 6| 0| 1| 4| 4| 4| 1| 1| 4| 4| 4| 1| 1| 4| 4| 0| 0| 9| 4| 9| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0.2%                                   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    71LF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  M  +  M  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  M  M|             
      Hyperplasia                          | 2  2  2  2     1     2  2     3  1  1        1  1  2  2     2  2  2      |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foot, Inflammation, Chronic Active   |                                     2                                    |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydrocephalus                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Histiocyte    | 1  1     1  1  1  1           1  1  1        1  1  1  1  1  1  1  1      |             
      Artery, Mineralization               |          1              1  1        1     1           1  1               |             
      Mediastinum, Polyarteritis           | 2                                                                        |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         | 4                 2                                3                     |             
      Metaplasia, Squamous                 |                   2                                                      |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                   +     +                             +           +      |             
      Phthisis Bulbi                       |                                                       4                  |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |          2                                                               |             
      Infarct                              |                                                    3                     |             
      Infiltration Cellular                |                                                                          |             
      Infiltration Cellular, Mononuclear   |                                                                          |             
          Cell                             |             1              1           1  1                          1  1|             
      Mineralization                       |             1                                                            |             
      Nephropathy                          | 3  2  3  4     2  3     3     4  2  2        2  2  4  4  2  2  2  1      |             
      Polyarteritis                        | 2                                                                        |             
      Pelvis, Inflammation, Chronic Active |                                                                          |             
      Renal Tubule, Hyperplasia            | 4        3     2     3  3                             3                  |             
      Renal Tubule, Inflammation, Acute    | 1                 1                                   1                  |             
      Renal Tubule, Pigmentation           | 2  2  2  2  2  2  2  2  2  1  1  2  2  1  1  2  2  2  2  2  2  2  2  2  2|             
      Renal Tubule, Regeneration           |             1                                                        1   |             
      Transitional Epithelium, Hyperplasia | 3        2              1     2                 1  1  2                  |             
      Transitional Epithelium,             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  21                                                               
NTP Experiment-Test: 05061-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 11:03:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 2| 7| 7| 7| 6| 2| 7| 7| 7| 2| 2| 7| 7| 7| 7| 6| 7| 6| 6| 2| 2|             
                             DAY ON TEST   | 3| 3| 1| 0| 8| 3| 3| 3| 1| 8| 3| 3| 3| 8| 8| 3| 3| 3| 3| 5| 3| 8| 6| 8| 8|             
                                           | 4| 4| 6| 0| 1| 4| 4| 4| 1| 1| 4| 4| 4| 1| 1| 4| 4| 0| 0| 9| 4| 9| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0.2%                                   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    71LF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
          Mineralization                   |    1                                                                     |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calculus Gross Observation           |                      X                                                   |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Inflammation, Chronic Active         | 2                                                                        |             
      Transitional Epithelium, Hyperplasia |                      3                                                   |             
      Transitional Epithelium, Metaplasia, |                                                                          |             
           Squamous                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  22                                                               
NTP Experiment-Test: 05061-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 11:03:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 2| 2| 7| 7| 7| 6| 2| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2|            |
                             DAY ON TEST   | 3| 3| 3| 8| 8| 3| 3| 3| 7| 7| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7|            |
                                           | 4| 4| 4| 1| 1| 4| 4| 3| 0| 9| 3| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|      A     |
    0.2%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|      L     |
    71LF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |          1  2  2                          1           1     1            |     13  1.3|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atypia Cellular                      |                                                                          |      1  1.0|
      Fibrosis                             |                                                                   2      |      1  2.0|
      Parasite Metazoan                    |                                        2  1     1                        |      4  1.5|
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Autolysis                            |                         3                                                |      1  3.0|
      Hemorrhage                           |       1                                                                  |      1  1.0|
      Parasite Metazoan                    |    1           1           1                          1                  |      7  1.1|
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Autolysis                            |                         4                                                |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|  49        |
      Autolysis                            |                         3                                                |      1  3.0|
      Parasite Metazoan                    |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                                          |      1  1.0|
      Basophilic Focus                     |       1              3        1  2  1  3  2        1        3        1   |     15  1.6|
      Clear Cell Focus                     | 1  2           2  2  3        1  2  2  2        2     1  1     2  2      |     28  1.6|
      Eosinophilic Focus                   | 2  2  3        3                       3        2        2     3  2      |     23  2.0|
      Hepatodiaphragmatic Nodule           |                         X                                X           X   |      4     |
      Hyperplasia, Focal                   |                   3                                                      |      1  3.0|
      Inflammation, Chronic Active         |    1           1     1                    1        1        1        1   |     16  1.2|
      Mixed Cell Focus                     |       2                       2        1        2  2     1  2            |     11  1.9|
      Necrosis, Coagulative                |                         3                 1                              |      4  1.5|
      Pigmentation                         |    1  1              1              1     1        2  1  1  1  1         |     21  1.0|
      Bile Duct, Hyperplasia               |    1  1  1  1                 1                                          |     10  1.0|
      Periportal, Inflammation, Chronic    |                                                                          |            |
          Active                           |          1  1              1                                            1|     12  1.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |          M  M              M  +           +                 +  +     +  M|   6        |
      Fibrosis                             |                               2           2                    2     2   |      5  2.0|
      Inflammation, Chronic Active         |                                           1                          2   |      3  1.7|
      Necrosis, Coagulative                |                               2           2                    2     3   |      5  2.4|
      Polyarteritis                        |                                                             4            |      1  4.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              | 1  1  1              1  2  1     1        3              2  3            |     19  1.6|
      Cytoplasmic Alteration               |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  23                                                               
NTP Experiment-Test: 05061-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 11:03:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 2| 2| 7| 7| 7| 6| 2| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2|            |
                             DAY ON TEST   | 3| 3| 3| 8| 8| 3| 3| 3| 7| 7| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7|            |
                                           | 4| 4| 4| 1| 1| 4| 4| 3| 0| 9| 3| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|      A     |
    0.2%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|      L     |
    71LF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Ectopic Tissue                       |                                                                          |      1  1.0|
      Infiltration Cellular, Mononuclear   |                                                                          |            |
          Cell                             |          1  1              1                                             |      7  1.0|
      Inflammation, Chronic Active         | 1  1  2        1  1  1  1     1  1        2  1        1  1  1            |     24  1.1|
      Polyarteritis                        |                                                             3            |      2  3.5|
                                            __________________________________________________________________________|____________|
   Pharynx                                 |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperkeratosis                       |    1  2              1              1                                    |      7  1.4|
      Hyperplasia, Basal Cell              |    1  2              1              1                                    |      7  1.6|
      Hyperplasia, Squamous                |    1  3              1              1                                    |      7  1.9|
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Ulcer                                |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                              +                           |   1        |
      Cyst                                 |                                              4                           |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       | 1  2  2     1  1  2  1  2     1  2  2  2  2  2  1  2  2  2  1  2  1  1  1|     46  1.4|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          | 1  2  1           2           1  1  2  1  3  2  1  1  2  2  1  1     1   |     32  1.5|
      Hyperplasia                          |                                  1                                       |      4  1.0|
      Vacuolization Cytoplasmic            |       1        1                 1  1        2           1               |     16  1.1|
      Zona Reticularis, Hyperplasia        |                            2                                             |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          | 2                                                                        |      5  1.6|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +        +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  40        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +|  47        |
      Hyperplasia                          |       2                                                                  |      3  2.3|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Pars Distalis, Angiectasis           |          2                                                               |      3  1.3|
      Pars Distalis, Cyst                  | 1  2  1                 3     1  2  1  1  1  2  2  1              3      |     21  1.5|
      Pars Distalis, Hyperplasia           |    2              2                                                      |     10  1.4|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                |                                                                          |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  24                                                               
NTP Experiment-Test: 05061-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 11:03:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 2| 2| 7| 7| 7| 6| 2| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2|            |
                             DAY ON TEST   | 3| 3| 3| 8| 8| 3| 3| 3| 7| 7| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7|            |
                                           | 4| 4| 4| 1| 1| 4| 4| 3| 0| 9| 3| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|      A     |
    0.2%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|      L     |
    71LF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      C-Cell, Hyperplasia                  |                                                             1            |      2  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | M  +  M  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|  46        |
      Cyst                                 |                                                                          |      1  1.0|
      Hyperplasia                          |                                                                          |      1  2.0|
      Inflammation, Chronic Active         |    1        1                    1  1        1     1        1     1     1|     21  1.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                                                          |      3  2.7|
      Pigmentation                         |                                                                         2|      1  2.0|
      Periovarian Tissue, Cyst             |             1                                                            |      4  1.8|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Abscess                              |                2                    2        2  2                        |      6  2.2|
      Cyst                                 |                3                    4        3  4                        |      5  3.4|
      Hydrometra                           |                                           1        2                 2   |      6  1.7|
      Endometrium, Hyperplasia             | 1                                            1        2  1           2   |      9  1.4|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Myelofibrosis                        |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |             +              +                                   +     +  M|  11        |
      Mediastinal, Hemorrhage              |                                                                          |      1  1.0|
      Mediastinal, Infiltration Cellular,  |                                                                          |            |
           Histiocyte                      |                                                                          |      1  1.0|
      Mediastinal, Pigmentation            |             1                                                            |      1  1.0|
      Pancreatic, Depletion Lymphoid       |                                                                          |      1  2.0|
      Pancreatic, Hemorrhage               |                                                                          |      2  1.5|
      Pancreatic, Infiltration Cellular,   |                                                                          |            |
           Histiocyte                      |                            2                                   1     2   |      8  1.6|
      Pancreatic, Pigmentation             |                            1                                             |      3  1.0|
      Renal, Hemorrhage                    |                                                                          |      1  1.0|
      Renal, Infiltration Cellular,        |                                                                          |            |
          Histiocyte                       |                                                                          |      1  3.0|
      Renal, Pigmentation                  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hemorrhage                           |          2                                                               |      3  1.3|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  25                                                               
NTP Experiment-Test: 05061-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 11:03:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 2| 2| 7| 7| 7| 6| 2| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2|            |
                             DAY ON TEST   | 3| 3| 3| 8| 8| 3| 3| 3| 7| 7| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7|            |
                                           | 4| 4| 4| 1| 1| 4| 4| 3| 0| 9| 3| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|      A     |
    0.2%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|      L     |
    71LF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia                          |                                                                          |      1  2.0|
      Infiltration Cellular, Histiocyte    |                   1                                                      |      2  1.0|
      Pigmentation                         |                            1                                             |      1  1.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Depletion Lymphoid                   |                                                                          |      1  3.0|
      Hemorrhage                           |          1                 2                                             |      4  1.3|
      Infiltration Cellular, Histiocyte    | 1  1  1  1  1  1  1  1  1  2  1  1  1  1  1  1  1  1  1  1     1  1  1  1|     49  1.1|
      Pigmentation                         |             1              1                                            1|      7  1.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Depletion Lymphoid                   |                         2                                                |      1  2.0|
      Fibrosis                             |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  +  M  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  41        |
      Cyst                                 |                                                    2                     |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  M  +  M  +  +  +  +  +  +  M  M  +  +  +  +  +  +  M  +  +  +  +  M  +|  38        |
      Hyperplasia                          | 2              3  2  2  2           1  2     2  2        2     1  1      |     29  1.8|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Foot, Inflammation, Chronic Active   |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         | +                                                                        |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hydrocephalus                        |                      2                                      2            |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infiltration Cellular, Histiocyte    | 1     1  1     1     1           1  1  1  1  1     1  1  1     1  1  1   |     33  1.0|
      Artery, Mineralization               |                                                          1              1|      9  1.0|
      Mediastinum, Polyarteritis           |                                                             2            |      2  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         | 1     1        4     3                 2                                 |      8  2.5|
      Metaplasia, Squamous                 |                1     2                 1                                 |      4  1.5|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  26                                                               
NTP Experiment-Test: 05061-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 11:03:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 2| 2| 7| 7| 7| 6| 2| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2|            |
                             DAY ON TEST   | 3| 3| 3| 8| 8| 3| 3| 3| 7| 7| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7|            |
                                           | 4| 4| 4| 1| 1| 4| 4| 3| 0| 9| 3| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|      A     |
    0.2%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|      L     |
    71LF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                     +                    +        +      |   7        |
      Phthisis Bulbi                       |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                                                          |      1  2.0|
      Infarct                              |                                                                          |      1  3.0|
      Infiltration Cellular                |                            1                                             |      1  1.0|
      Infiltration Cellular, Mononuclear   |                                                                          |            |
          Cell                             |          1  1              1                                             |      9  1.0|
      Mineralization                       |                                                                          |      1  1.0|
      Nephropathy                          | 3  3  4        3  2  3  2     3  3  2  2  1  3  2  3  3  2  2  2  3  2   |     39  2.6|
      Polyarteritis                        |                                                                          |      1  2.0|
      Pelvis, Inflammation, Chronic Active |                                                       2                  |      1  2.0|
      Renal Tubule, Hyperplasia            |       3        3  1  2                 1                          2      |     12  2.5|
      Renal Tubule, Inflammation, Acute    | 1  1  1        1                                                         |      7  1.0|
      Renal Tubule, Pigmentation           | 2  2  2  2  2  2  2  1  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2|     50  1.9|
      Renal Tubule, Regeneration           |             1              1                                            1|      5  1.0|
      Transitional Epithelium, Hyperplasia | 2  1  3        3                 1  1                 3           1  1   |     16  1.8|
      Transitional Epithelium,             |                                                                          |            |
          Mineralization                   |                                     1     1                          1   |      4  1.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Calculus Gross Observation           |                   X                                                      |      2     |
      Hyperplasia, Lymphoid                |                      1        1                                          |      2  1.0|
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Transitional Epithelium, Hyperplasia |                   3                                                      |      2  3.0|
      Transitional Epithelium, Metaplasia, |                                                                          |            |
           Squamous                        |                   1                                                      |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  27                                                               
NTP Experiment-Test: 05061-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 11:03:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 7| 2| 7| 7| 7| 7| 2| 7| 7| 7| 7| 2| 7| 7| 7| 6| 2|             
                             DAY ON TEST   | 2| 2| 2| 2| 6| 2| 2| 2| 2| 8| 2| 2| 2| 2| 7| 3| 3| 3| 1| 7| 3| 3| 3| 4| 8|             
                                           | 9| 9| 9| 9| 7| 9| 9| 9| 9| 1| 9| 9| 9| 9| 9| 0| 0| 0| 9| 9| 0| 0| 0| 9| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    0.5%                                   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    71MLF                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |             1                                                            |             
      Parasite Metazoan                    |       2     1     1     2           1                                   1|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atypia Cellular                      |                                                 1           1            |             
      Autolysis                            |             3                                         3                  |             
      Parasite Metazoan                    |       1                                1        1                    1   |             
      Epithelium, Hyperplasia              |                                        1                                 |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |             3                                         3                  |             
      Mineralization                       |                   1                                                      |             
      Parasite Metazoan                    |                                     2                             1      |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                       3                  |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Autolysis                            |             4                                                            |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |             4                                         3                  |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |             1                                         1                  |             
      Basophilic Focus                     |    1     1           4  1           4        2  2  1  2           1  1   |             
      Clear Cell Focus                     |    1  1           2  4        1  2  2  2     2  2           1  3         |             
      Degeneration                         |                                                                          |             
      Eosinophilic Focus                   |    1        1  2        2        3           3     3           4         |             
      Fatty Change                         |                                                          1               |             
      Hematopoietic Cell Proliferation     | 1  2     1                                         1           1         |             
      Hepatodiaphragmatic Nodule           |                                              X                           |             
      Inflammation, Chronic Active         | 1                             1     1  2        1  1  1        1  1      |             
      Mixed Cell Focus                     |                         1                    1              1        1   |             
      Necrosis, Coagulative                |                                                                          |             
      Pigmentation                         | 1  1  1  2  1  2  2  1  1  1  2  1  1  2     1  1           2  2  2  2  1|             
      Bile Duct, Hyperplasia               | 1  1  2  2  2  1  2  2  1  1  3  2  2  2  1  2  2  2  1  1  2  2  2  2   |             
      Periportal, Inflammation, Chronic    |                                                                          |             
          Active                           |    1  1  1  2  1  2  2  1  1  1  2  2  2  1  2  2  2  1  1  2  2  2  2  1|             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Fibrosis                             |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Necrosis, Coagulative                |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 4  1  1        1                    1              2                     |             
      Autolysis                            |                                                                          |             
      Cytoplasmic Alteration               |                                                             1            |             
      Ectopic Liver                        |                                                             X            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  28                                                               
NTP Experiment-Test: 05061-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 11:03:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 7| 2| 7| 7| 7| 7| 2| 7| 7| 7| 7| 2| 7| 7| 7| 6| 2|             
                             DAY ON TEST   | 2| 2| 2| 2| 6| 2| 2| 2| 2| 8| 2| 2| 2| 2| 7| 3| 3| 3| 1| 7| 3| 3| 3| 4| 8|             
                                           | 9| 9| 9| 9| 7| 9| 9| 9| 9| 1| 9| 9| 9| 9| 9| 0| 0| 0| 9| 9| 0| 0| 0| 9| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    0.5%                                   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    71MLF                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Infiltration Cellular, Mononuclear   |                                                                          |             
          Cell                             |                                                          1               |             
      Infiltration Cellular, Mixed Cell    |                                                                         2|             
      Inflammation, Chronic Active         | 2  1  1        1  1     1        1  1        1  1  1              1  1   |             
      Vacuolization Cytoplasmic            |             2        1  1     1        1                          1      |             
      Acinus, Hyperplasia                  |                                        2                                 |             
      Duct, Hyperplasia                    |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Parotid Gland, Inflammation, Chronic |                                                                          |             
          Active                           |                1                                                         |             
      Submandibular Gland, Inflammation,   |                                                                          |             
           Chronic Active                  |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                          |             
      Hyperkeratosis                       |                         2     2        2              2     1            |             
      Hyperplasia, Basal Cell              |    1  1     1     2     2     2  2  2  2              2     1            |             
      Hyperplasia, Squamous                |    2                    4     4  2  2  3              2     3            |             
      Inflammation, Chronic Active         |                         2     2                                          |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                       1                  |             
      Fibrosis                             |                                                                          |             
      Inflammation, Chronic Active         |                                     1              1              1      |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1  1  1  2  1  2  1  1  1  1  1  1  1        1  1  1  1     1  1  1  1  1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 1     1        1  1  2        1  2  2  1     1                       1   |             
      Hyperplasia                          |                                                       1                  |             
      Vacuolization Cytoplasmic            |    1  1  2     1     1  3     1     1  1     1        1     1  1         |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |          2     1        2        2  1           1                 2      |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Hyperplasia                          |                         2                                                |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                                                                          |             
      Pars Distalis, Autolysis             |             2                                                            |             
      Pars Distalis, Cyst                  |          1           2  1                          1           2     1   |             
      Pars Distalis, Hyperplasia           |          1           2              1                          2  1      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  29                                                               
NTP Experiment-Test: 05061-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 11:03:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 7| 2| 7| 7| 7| 7| 2| 7| 7| 7| 7| 2| 7| 7| 7| 6| 2|             
                             DAY ON TEST   | 2| 2| 2| 2| 6| 2| 2| 2| 2| 8| 2| 2| 2| 2| 7| 3| 3| 3| 1| 7| 3| 3| 3| 4| 8|             
                                           | 9| 9| 9| 9| 7| 9| 9| 9| 9| 1| 9| 9| 9| 9| 9| 0| 0| 0| 9| 9| 0| 0| 0| 9| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    0.5%                                   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    71MLF                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pars Distalis, Pars Intermedia, Cyst |                                                                          |             
      Pars Intermedia, Cyst                |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Inflammation, Chronic Active         |                                                             1            |             
      Ultimobranchial Cyst                 |                                                                          |             
      C-Cell, Hyperplasia                  |                                                                          |             
      Follicle, Cyst                       |             2                                                            |             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Abscess                              |                                  2                    2                  |             
      Inflammation, Chronic Active         | 1  1  1                 1     1  2  1  1     1  1           1  1  1  1  1|             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                      2                                            2  1   |             
      Periovarian Tissue, Cyst             |                                           2                              |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |    4     3                                                               |             
      Decidual Reaction                    |                                                                          |             
      Fibrosis                             |                                                 2                        |             
      Hydrometra                           |                         2        2              1              3         |             
      Endometrium, Hyperplasia             |          1                                                               |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +        +        +  +  +  +  +  +  +     M              M  +  +  +     M|             
      Mediastinal, Hemorrhage              |                            2                                             |             
      Mediastinal, Infiltration Cellular,  |                                                                          |             
           Histiocyte                      |                                  1                          1            |             
      Mediastinal, Pigmentation            |                            1                                             |             
      Pancreatic, Hemorrhage               |                                                                          |             
      Pancreatic, Hyperplasia              | 2        2        3                                            2  1      |             
      Pancreatic, Infiltration Cellular,   |                                                                          |             
           Histiocyte                      | 2        2        1  2  1     2     2                          2  1      |             
      Pancreatic, Pigmentation             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                            2              1              2               |             
      Hyperplasia                          |                                                                          |             
      Infiltration Cellular, Histiocyte    |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  30                                                               
NTP Experiment-Test: 05061-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 11:03:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 7| 2| 7| 7| 7| 7| 2| 7| 7| 7| 7| 2| 7| 7| 7| 6| 2|             
                             DAY ON TEST   | 2| 2| 2| 2| 6| 2| 2| 2| 2| 8| 2| 2| 2| 2| 7| 3| 3| 3| 1| 7| 3| 3| 3| 4| 8|             
                                           | 9| 9| 9| 9| 7| 9| 9| 9| 9| 1| 9| 9| 9| 9| 9| 0| 0| 0| 9| 9| 0| 0| 0| 9| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    0.5%                                   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    71MLF                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Depletion Lymphoid                   |                                                       3                  |             
      Hemorrhage                           |                                           2                              |             
      Infiltration Cellular, Histiocyte    | 1  1  2     1  1  2  1  1  1  1  1  1  1  2  2  1  1  1  1  1  1  1  1  2|             
      Pigmentation                         |                            1              1              1              2|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Depletion Lymphoid                   |                                                       3                  |             
      Fibrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +|             
      Depletion Lymphoid                   |                                                                          |             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  M  M  +  M  +  +  M  M  +  M  +  M  +  +  +  +  +|             
      Hyperplasia                          | 1  1  1  1  2  2  2  1        1        1        1     1     2  1  1  1   |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                                                          |             
      Foreign Body                         |                                                                          |             
      Inflammation, Chronic Active         |       1                          1                                       |             
      Foot, Acanthosis                     |                                                                          |             
      Foot, Hyperkeratosis                 |                                                                          |             
      Foot, Inflammation, Chronic Active   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infarct                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Infiltration Cellular, Histiocyte    | 1     1     1  1  1  1  1     1  1  1  1     1  1  1  1     1  1  1  1   |             
      Inflammation, Chronic Active         |                                                                   1      |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Artery, Mineralization               | 1     1        1        1  1        1                 1        1        1|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                                                   2      |             
      Inflammation, Chronic Active         |          3                                   3                    2      |             
      Metaplasia, Squamous                 |          1                                                               |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  31                                                               
NTP Experiment-Test: 05061-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 11:03:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 7| 2| 7| 7| 7| 7| 2| 7| 7| 7| 7| 2| 7| 7| 7| 6| 2|             
                             DAY ON TEST   | 2| 2| 2| 2| 6| 2| 2| 2| 2| 8| 2| 2| 2| 2| 7| 3| 3| 3| 1| 7| 3| 3| 3| 4| 8|             
                                           | 9| 9| 9| 9| 7| 9| 9| 9| 9| 1| 9| 9| 9| 9| 9| 0| 0| 0| 9| 9| 0| 0| 0| 9| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    0.5%                                   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    71MLF                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                   +  +   |             
      External Ear, Inflammation, Acute    |                                                                      3   |             
      Internal Ear, Inflammation, Acute    |                                                                      3   |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                    +              +      |             
      Phthisis Bulbi                       |                                                                   4      |             
      Lens, Cataract                       |                                                                          |             
      Retina, Degeneration                 |                                                                   3      |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                      +   |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |          2                                                               |             
      Autolysis                            |                                                                          |             
      Cyst                                 |    2                                                                     |             
      Fibrosis                             |                                                                          |             
      Hydronephrosis                       |          2                                                               |             
      Infiltration Cellular, Mononuclear   |                                                                          |             
          Cell                             |                                           1              1              1|             
      Inflammation, Chronic Active         |                                              2                           |             
      Nephropathy                          | 2  3  2  4  2  3  3  3  4     2  3  2  2     2  3  2  3     3  2  2  2   |             
      Pigmentation                         |                                                                          |             
      Artery, Thrombosis                   |                         4                                                |             
      Pelvis, Inflammation, Chronic Active |    3                                                                     |             
      Pelvis, Metaplasia, Squamous         |    4                                                                     |             
      Renal Tubule, Hyperplasia            | 1  3                 3  4        2     2     4  3           2     2      |             
      Renal Tubule, Hyperplasia, Oncocytic |                                                                4         |             
      Renal Tubule, Inflammation, Acute    |       1        1                                1                        |             
      Renal Tubule, Inflammation, Chronic  |                                                                          |             
          Active                           |                                                                          |             
      Renal Tubule, Pigmentation           | 2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2|             
      Renal Tubule, Regeneration           |                            1                             1               |             
      Transitional Epithelium, Hyperplasia | 1  4  2     1  1  2  1  3     1        2     2  1  1  1     1  1  1  1   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Fibrosis                             |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                1         |             
      Inflammation, Chronic Active         |    1                                1                                    |             
      Fat, Proliferation                   |                                     2           2                        |             
      Transitional Epithelium, Hyperplasia | 2  2  1     2  2  2  1  2     1     2  1        1  2  1     1  2     2   |             
      Transitional Epithelium, Metaplasia, |                                                                          |             
           Squamous                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  32                                                               
NTP Experiment-Test: 05061-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 11:03:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 2| 7| 7| 6| 6| 6| 7| 6| 5| 2| 2| 7| 7| 6| 6| 2| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 3| 3| 3| 1| 8| 3| 3| 9| 7| 0| 3| 9| 8| 8| 7| 3| 3| 6| 4| 7| 3| 3| 3| 3| 3|             
                                           | 0| 0| 0| 6| 1| 0| 0| 6| 0| 6| 0| 1| 2| 1| 9| 0| 0| 0| 2| 9| 0| 0| 0| 0| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    0.5%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    71MLF                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |          3           3  3                             4                  |             
      Parasite Metazoan                    |                                                 1                 1      |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atypia Cellular                      |                                              1  2           1            |             
      Autolysis                            |          2           2  3                             2                  |             
      Parasite Metazoan                    |                   1                 1     1        1                     |             
      Epithelium, Hyperplasia              | 1                                2                                       |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |          4           3  4                             4                  |             
      Mineralization                       |                                                                          |             
      Parasite Metazoan                    |                   1                                                      |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |          3           1  1                             3                  |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |          4           4  2                    1     1  4                  |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |          4           3  4        2                    4                  |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |          2                                            2                  |             
      Basophilic Focus                     | 2  1                 2              2        2  2              2  1  1   |             
      Clear Cell Focus                     | 2  2  2  2     2  2  2        4  2           3  2           3  2  2  2   |             
      Degeneration                         |    1                                                           1  1      |             
      Eosinophilic Focus                   |    4                                                                     |             
      Fatty Change                         |                                                                         3|             
      Hematopoietic Cell Proliferation     |                                                    1           1         |             
      Hepatodiaphragmatic Nodule           |                                                                          |             
      Inflammation, Chronic Active         | 2                    1              1        1              2  1  1      |             
      Mixed Cell Focus                     | 2                                                                        |             
      Necrosis, Coagulative                |    1           1                             1     1              1      |             
      Pigmentation                         | 1  1  1  1  1  1  1  1        1  1  2  1  1  1  2  1     1  2  1  1  1   |             
      Bile Duct, Hyperplasia               | 2  2  2  1  1  2  2  2  2     2  1  2  1  1  2  2  2     1  3  2  2  1  2|             
      Periportal, Inflammation, Chronic    |                                                                          |             
          Active                           | 2  2  2     1  2  2  2  3     2  1  2  1  1  1  1  2     1  2  2  2  1  1|             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Fibrosis                             |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Necrosis, Coagulative                |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                      4                       1  2                 2      |             
      Autolysis                            |                                                       2                  |             
      Cytoplasmic Alteration               |                                                                          |             
      Ectopic Liver                        |                      X                                                   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  33                                                               
NTP Experiment-Test: 05061-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 11:03:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 2| 7| 7| 6| 6| 6| 7| 6| 5| 2| 2| 7| 7| 6| 6| 2| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 3| 3| 3| 1| 8| 3| 3| 9| 7| 0| 3| 9| 8| 8| 7| 3| 3| 6| 4| 7| 3| 3| 3| 3| 3|             
                                           | 0| 0| 0| 6| 1| 0| 0| 6| 0| 6| 0| 1| 2| 1| 9| 0| 0| 0| 2| 9| 0| 0| 0| 0| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    0.5%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    71MLF                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Infiltration Cellular, Mononuclear   |                                                                          |             
          Cell                             |                                                                          |             
      Infiltration Cellular, Mixed Cell    |                                                                          |             
      Inflammation, Chronic Active         |    1                 2              2        1  1              1  1  1   |             
      Vacuolization Cytoplasmic            |          1                    1                             2        1   |             
      Acinus, Hyperplasia                  |                                                                          |             
      Duct, Hyperplasia                    |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |             2                                                            |             
      Parotid Gland, Inflammation, Chronic |                                                                          |             
          Active                           |                                                                1         |             
      Submandibular Gland, Inflammation,   |                                                                          |             
           Chronic Active                  |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                  2                                      3|             
      Hyperkeratosis                       |          3           2  3        3                    2        1        2|             
      Hyperplasia, Basal Cell              |    4  2        1     1  4        3           1  1     2                 2|             
      Hyperplasia, Squamous                |    2  4  3              3        3                             3        3|             
      Inflammation, Chronic Active         |       2  3                       3                             1        2|             
      Ulcer                                |          3                                                               |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |          2                                            2                  |             
      Fibrosis                             |                               1                                          |             
      Inflammation, Chronic Active         |                               1                                         1|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1  1  1  1  1  1  1  1  1  1  1  1  2     1  1  1  1     1  1  2  1  1   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 1     1  1     2  1           2              2  1  1  2     1  2  1  1   |             
      Hyperplasia                          |                1  1                                                      |             
      Vacuolization Cytoplasmic            | 1        3        1     2  1  1  1  2           1           1        3   |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                               1                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +     +  +  +  +  +  +  +  +        +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                                                                          |             
      Pars Distalis, Autolysis             |                                                       2                  |             
      Pars Distalis, Cyst                  |    1        1  2  1     2           1     1                 1            |             
      Pars Distalis, Hyperplasia           | 1  2              1        1                 2              1            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  34                                                               
NTP Experiment-Test: 05061-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 11:03:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 2| 7| 7| 6| 6| 6| 7| 6| 5| 2| 2| 7| 7| 6| 6| 2| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 3| 3| 3| 1| 8| 3| 3| 9| 7| 0| 3| 9| 8| 8| 7| 3| 3| 6| 4| 7| 3| 3| 3| 3| 3|             
                                           | 0| 0| 0| 6| 1| 0| 0| 6| 0| 6| 0| 1| 2| 1| 9| 0| 0| 0| 2| 9| 0| 0| 0| 0| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    0.5%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    71MLF                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pars Distalis, Pars Intermedia, Cyst |             1                             1                              |             
      Pars Intermedia, Cyst                |             1                 2           1                              |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |          3                                                               |             
      Inflammation, Chronic Active         |                                                                          |             
      Ultimobranchial Cyst                 |                                                                          |             
      C-Cell, Hyperplasia                  |                2                                               1         |             
      Follicle, Cyst                       |                                                                          |             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              | +                                                                        |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                      4                                                   |             
      Inflammation, Chronic Active         | 1  1  1  1     1  1     1  1  1     1     1  1  1  1  1  1  1     1  1  1|             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Periovarian Tissue, Cyst             |                                           2              2               |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                         3                                         3  4   |             
      Decidual Reaction                    |                                           3                              |             
      Fibrosis                             |                                                                          |             
      Hydrometra                           |                            1        2        2           2               |             
      Endometrium, Hyperplasia             |                   2                                                      |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |             +     +        +  +     +  M  +  +  +        M  +  +         |             
      Mediastinal, Hemorrhage              |             1                             2                              |             
      Mediastinal, Infiltration Cellular,  |                                                                          |             
           Histiocyte                      |                                                                          |             
      Mediastinal, Pigmentation            |             1                                                            |             
      Pancreatic, Hemorrhage               |             2                                                            |             
      Pancreatic, Hyperplasia              |                                                                          |             
      Pancreatic, Infiltration Cellular,   |                                                                          |             
           Histiocyte                      |                   2           3     1        2  2           2  3         |             
      Pancreatic, Pigmentation             |             1                                                            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Hemorrhage                           |                                           1              1               |             
      Hyperplasia                          | 2                                                                        |             
      Infiltration Cellular, Histiocyte    |                                     1                                    |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  35                                                               
NTP Experiment-Test: 05061-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 11:03:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 2| 7| 7| 6| 6| 6| 7| 6| 5| 2| 2| 7| 7| 6| 6| 2| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 3| 3| 3| 1| 8| 3| 3| 9| 7| 0| 3| 9| 8| 8| 7| 3| 3| 6| 4| 7| 3| 3| 3| 3| 3|             
                                           | 0| 0| 0| 6| 1| 0| 0| 6| 0| 6| 0| 1| 2| 1| 9| 0| 0| 0| 2| 9| 0| 0| 0| 0| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    0.5%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    71MLF                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Depletion Lymphoid                   |                                                                          |             
      Hemorrhage                           |                                        1  2                              |             
      Infiltration Cellular, Histiocyte    | 1  1  1  1  2  1  1  1  1  1  1  1  1  2  2  1  1  1  1  1  2  1  1  1  2|             
      Pigmentation                         |             2                                            1               |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Depletion Lymphoid                   |                      2  2                                                |             
      Fibrosis                             |                                                                   1      |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M|             
      Depletion Lymphoid                   |                                                                          |             
      Hemorrhage                           |                                           2                              |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +|             
      Hyperplasia                          |       2  2     1  1  2  1     1  2                 3  2        2     1   |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                               3                                   2      |             
      Foreign Body                         |                                                                          |             
      Inflammation, Chronic Active         |                                                 1                        |             
      Foot, Acanthosis                     |                                              2                           |             
      Foot, Hyperkeratosis                 |                                              2                           |             
      Foot, Inflammation, Chronic Active   |                                              2                           |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infarct                              |                                                       2                  |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                              1                    1      |             
      Hemorrhage                           |             1                                                            |             
      Infiltration Cellular, Histiocyte    | 1  1  1        1  1  1        1  1  1  1  1  1  1  1        1  1  1  1  1|             
      Inflammation, Chronic Active         |                                              1                    1      |             
      Alveolar Epithelium, Hyperplasia     |                                           1                              |             
      Artery, Mineralization               |                      1  1  1  1     1           1        1     1        1|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |          2                                                               |             
      Inflammation, Chronic Active         | 3     1  3     3  1                                1                     |             
      Metaplasia, Squamous                 | 2        2                                                               |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  36                                                               
NTP Experiment-Test: 05061-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 11:03:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 2| 7| 7| 6| 6| 6| 7| 6| 5| 2| 2| 7| 7| 6| 6| 2| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 3| 3| 3| 1| 8| 3| 3| 9| 7| 0| 3| 9| 8| 8| 7| 3| 3| 6| 4| 7| 3| 3| 3| 3| 3|             
                                           | 0| 0| 0| 6| 1| 0| 0| 6| 0| 6| 0| 1| 2| 1| 9| 0| 0| 0| 2| 9| 0| 0| 0| 0| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    0.5%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    71MLF                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                +                                   +  +        +  +      |             
      External Ear, Inflammation, Acute    |                                                                3         |             
      Internal Ear, Inflammation, Acute    |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |    +           +  +                                                      |             
      Phthisis Bulbi                       |                                                                          |             
      Lens, Cataract                       |                                                                          |             
      Retina, Degeneration                 |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                +         |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                                          |             
      Autolysis                            |          3           3                                2                  |             
      Cyst                                 |    1                                                                     |             
      Fibrosis                             |                                                                          |             
      Hydronephrosis                       |                         2                                                |             
      Infiltration Cellular, Mononuclear   |                                                                          |             
          Cell                             |             1                          1                 1               |             
      Inflammation, Chronic Active         |                                                                          |             
      Nephropathy                          | 2  3  3  2     3  3  3  3  3  3  3  2        3  3  2  2     2  3  3  3  2|             
      Pigmentation                         |             2                                                            |             
      Artery, Thrombosis                   |                                                                          |             
      Pelvis, Inflammation, Chronic Active |                         2                                   2            |             
      Pelvis, Metaplasia, Squamous         |                      2                                                   |             
      Renal Tubule, Hyperplasia            | 2                 3  1        1                                      4   |             
      Renal Tubule, Hyperplasia, Oncocytic |                                                                          |             
      Renal Tubule, Inflammation, Acute    |                                                                          |             
      Renal Tubule, Inflammation, Chronic  |                                                                          |             
          Active                           |                                  1                                       |             
      Renal Tubule, Pigmentation           | 2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  1|             
      Renal Tubule, Regeneration           |                                        1  1              1               |             
      Transitional Epithelium, Hyperplasia |    1  1  1     1  1  3  2  1  1  1  1           1  1  3     3     1      |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                      3                                3                  |             
      Fibrosis                             |                                                                          |             
      Hyperplasia, Lymphoid                |                            2                                             |             
      Inflammation, Chronic Active         |                                                                          |             
      Fat, Proliferation                   |                                                                          |             
      Transitional Epithelium, Hyperplasia |          2     3  2  4  2     3  2  3        2     2        2        1   |             
      Transitional Epithelium, Metaplasia, |                                                                          |             
           Squamous                        |                      3  2     2                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  37                                                               
NTP Experiment-Test: 05061-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 11:03:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 5| 7| 7| 7| 6| 2| 7| 7| 7| 6| 6| 7| 7| 6| 6| 2|              |            |
                             DAY ON TEST   | 2| 2| 1| 0| 7| 3| 3| 0| 9| 7| 3| 3| 2| 4| 0| 2| 2| 6| 4| 8|              |            |
                                           | 9| 9| 4| 9| 5| 0| 0| 8| 5| 9| 0| 0| 5| 9| 1| 9| 9| 0| 7| 1|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      A     |
    0.5%                                   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|              |      L     |
    71MLF                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +               |  67        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  69        |
      Autolysis                            |                                                                          |      5  2.8|
      Parasite Metazoan                    |                            2                                             |      9  1.3|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Atypia Cellular                      |                                                    2                     |      6  1.3|
      Autolysis                            |                                                                          |      6  2.5|
      Parasite Metazoan                    |                                                    1                     |      9  1.0|
      Epithelium, Hyperplasia              |                                                                          |      3  1.3|
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Autolysis                            |                                                                          |      6  3.5|
      Mineralization                       |                                                                          |      1  1.0|
      Parasite Metazoan                    | 1                                1                                       |      5  1.2|
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  69        |
      Autolysis                            |                                                                          |      5  2.2|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  69        |
      Autolysis                            |                                                       1                  |      8  2.6|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +               |  69        |
      Autolysis                            |                                                       3                  |      8  3.4|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Autolysis                            |                                                                          |      4  1.5|
      Basophilic Focus                     |                         1        1                                       |     22  1.7|
      Clear Cell Focus                     |    2  2     1  3  1  3  2     1  2  2           2  1                     |     39  2.0|
      Degeneration                         |                                                                          |      3  1.0|
      Eosinophilic Focus                   |                1                             3     3                     |     12  2.5|
      Fatty Change                         |                                        3              4                  |      4  2.8|
      Hematopoietic Cell Proliferation     |                                  1  1        1                           |     10  1.1|
      Hepatodiaphragmatic Nodule           |                                                                          |      1     |
      Inflammation, Chronic Active         | 1           1  1  1     1           2  1                                 |     23  1.2|
      Mixed Cell Focus                     |                                                                          |      5  1.2|
      Necrosis, Coagulative                |    1     2     1  1     1                       1                        |     11  1.1|
      Pigmentation                         | 2  2  2     1  2  1  2  1     1  1  2  2        2  1  1                  |     57  1.4|
      Bile Duct, Hyperplasia               | 2  2  2  1  1  2  2  2  1  1  1  1  2        1  2  2  1  1               |     65  1.7|
      Periportal, Inflammation, Chronic    |                                                                          |            |
          Active                           | 2  2  1  1  1  2  2  2     1  1  1  2  2     1  2  2  1  1               |     64  1.6|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                      +                                                   |   1        |
      Fibrosis                             |                      2                                                   |      1  2.0|
      Inflammation, Chronic Active         |                      2                                                   |      1  2.0|
      Necrosis, Coagulative                |                      2                                                   |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  38                                                               
NTP Experiment-Test: 05061-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 11:03:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 5| 7| 7| 7| 6| 2| 7| 7| 7| 6| 6| 7| 7| 6| 6| 2|              |            |
                             DAY ON TEST   | 2| 2| 1| 0| 7| 3| 3| 0| 9| 7| 3| 3| 2| 4| 0| 2| 2| 6| 4| 8|              |            |
                                           | 9| 9| 4| 9| 5| 0| 0| 8| 5| 9| 0| 0| 5| 9| 1| 9| 9| 0| 7| 1|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      A     |
    0.5%                                   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|              |      L     |
    71MLF                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Atrophy                              |          1  1     3  1           1        1                              |     16  1.7|
      Autolysis                            |                                                                          |      1  2.0|
      Cytoplasmic Alteration               |                                     1                                    |      2  1.0|
      Ectopic Liver                        |                                                                          |      2     |
      Infiltration Cellular, Mononuclear   |                                                                          |            |
          Cell                             |                                                                          |      1  1.0|
      Infiltration Cellular, Mixed Cell    |                                                                          |      1  2.0|
      Inflammation, Chronic Active         |             1     2  1        2  1  1  1     1     1                     |     30  1.2|
      Vacuolization Cytoplasmic            |                   2                                   1                  |     12  1.3|
      Acinus, Hyperplasia                  |                                                                          |      1  2.0|
      Duct, Hyperplasia                    |          1                                                               |      1  1.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  2.0|
      Parotid Gland, Inflammation, Chronic |                                                                          |            |
          Active                           |                                                                          |      2  1.0|
      Submandibular Gland, Inflammation,   |                                                                          |            |
           Chronic Active                  |                               1                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Erosion                              |                                                                          |      2  2.5|
      Hyperkeratosis                       | 2     3        2     2  2           2  2     2  2  3  2                  |     23  2.1|
      Hyperplasia, Basal Cell              | 2  1  2  1     2     2  2        1  2  2     2  2  2  2                  |     35  1.8|
      Hyperplasia, Squamous                | 3     4        3     2  3           3  3     3  2  4  3                  |     26  2.9|
      Inflammation, Chronic Active         |       3        2        2                       3  2  2                  |     13  2.2|
      Ulcer                                |       2              1              1  2     2        1                  |      7  1.7|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Autolysis                            |                                                                          |      3  1.7|
      Fibrosis                             |                                                                          |      1  1.0|
      Inflammation, Chronic Active         |                         2                                                |      6  1.2|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Cardiomyopathy                       |    1  1  2     1  2  1  1  1     1  2  1  1  1  1  1  1                  |     60  1.1|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  69        |
      Angiectasis                          | 2  1  1  2  2  1  1     2  1  2  2  2  1        1  2  1                  |     41  1.4|
      Hyperplasia                          |                            1                                             |      4  1.0|
      Vacuolization Cytoplasmic            |          1  2  1  1  1  1        1        2  1  1     1                  |     35  1.3|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  39                                                               
NTP Experiment-Test: 05061-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 11:03:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 5| 7| 7| 7| 6| 2| 7| 7| 7| 6| 6| 7| 7| 6| 6| 2|              |            |
                             DAY ON TEST   | 2| 2| 1| 0| 7| 3| 3| 0| 9| 7| 3| 3| 2| 4| 0| 2| 2| 6| 4| 8|              |            |
                                           | 9| 9| 4| 9| 5| 0| 0| 8| 5| 9| 0| 0| 5| 9| 1| 9| 9| 0| 7| 1|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      A     |
    0.5%                                   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|              |      L     |
    71MLF                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  69        |
      Hyperplasia                          |       1           1                       2                              |     11  1.5|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +                  |  60        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +               |  67        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Pars Distalis, Angiectasis           |                   1                                                      |      1  1.0|
      Pars Distalis, Autolysis             |                                                                          |      2  2.0|
      Pars Distalis, Cyst                  |          2     2  2        2           1  1  3     1     1               |     23  1.4|
      Pars Distalis, Hyperplasia           |       2        2  2              2                                       |     15  1.5|
      Pars Distalis, Pars Intermedia, Cyst |                                                                          |      2  1.0|
      Pars Intermedia, Cyst                |                                                                          |      3  1.3|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Autolysis                            |                                                                          |      1  3.0|
      Inflammation, Chronic Active         |                                                                          |      1  1.0|
      Ultimobranchial Cyst                 |                            1                                             |      1  1.0|
      C-Cell, Hyperplasia                  |                                              1                           |      3  1.3|
      Follicle, Cyst                       |                                                                          |      1  2.0|
      Follicular Cell, Hyperplasia         |                            1                                             |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +               |  68        |
      Abscess                              |                                                                          |      3  2.7|
      Inflammation, Chronic Active         | 1  1  2     1  2  1  1  1     1  1  1  1  1  1        1  2               |     51  1.1|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Cyst                                 |          3                                   2                           |      5  2.0|
      Periovarian Tissue, Cyst             |                                                                          |      3  2.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Abscess                              |                   2           3                 4                        |      8  3.3|
      Decidual Reaction                    |                                                                          |      1  3.0|
      Fibrosis                             |                                                                          |      1  2.0|
      Hydrometra                           |                                              2                           |      9  1.9|
      Endometrium, Hyperplasia             |                                                                          |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  40                                                               
NTP Experiment-Test: 05061-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 11:03:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 5| 7| 7| 7| 6| 2| 7| 7| 7| 6| 6| 7| 7| 6| 6| 2|              |            |
                             DAY ON TEST   | 2| 2| 1| 0| 7| 3| 3| 0| 9| 7| 3| 3| 2| 4| 0| 2| 2| 6| 4| 8|              |            |
                                           | 9| 9| 4| 9| 5| 0| 0| 8| 5| 9| 0| 0| 5| 9| 1| 9| 9| 0| 7| 1|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      A     |
    0.5%                                   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|              |      L     |
    71MLF                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |    +           +  +        M              +  +  +        M               |  28        |
      Mediastinal, Hemorrhage              |                                                                          |      3  1.7|
      Mediastinal, Infiltration Cellular,  |                                                                          |            |
           Histiocyte                      |                                                                          |      2  1.0|
      Mediastinal, Pigmentation            |                                                                          |      2  1.0|
      Pancreatic, Hemorrhage               |                                                                          |      1  2.0|
      Pancreatic, Hyperplasia              |                                                                          |      5  2.0|
      Pancreatic, Infiltration Cellular,   |                                                                          |            |
           Histiocyte                      |    1           2  2                          1  2                        |     21  1.8|
      Pancreatic, Pigmentation             |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  66        |
      Hemorrhage                           |                                                                          |      5  1.4|
      Hyperplasia                          |             2                                                            |      2  2.0|
      Infiltration Cellular, Histiocyte    |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  69        |
      Depletion Lymphoid                   |                                     2                                    |      2  2.5|
      Hemorrhage                           |                            2                                             |      4  1.8|
      Infiltration Cellular, Histiocyte    | 1  1  1  1  2  1  1  1  1  1     1  1  1     1  1  1  1  1               |     67  1.2|
      Pigmentation                         |                            1                             1               |      8  1.3|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Depletion Lymphoid                   |                                                                          |      3  2.3|
      Fibrosis                             |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  I  +  +  +  +  +  +  +  +  +  M  M  +  +  +  M  +               |  61        |
      Depletion Lymphoid                   |                            2                                             |      1  2.0|
      Hemorrhage                           |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  M  +  +  +  +               |  54        |
      Hyperplasia                          |    1  1     2  1  1  1        1  2  2  1        2  1  1                  |     41  1.4|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Cyst Epithelial Inclusion            |                                                                          |      2  2.5|
      Foreign Body                         |                                  1                                       |      1  1.0|
      Inflammation, Chronic Active         |                                  1     1              2                  |      6  1.2|
      Foot, Acanthosis                     |                                                                          |      1  2.0|
      Foot, Hyperkeratosis                 |                                                                          |      1  2.0|
      Foot, Inflammation, Chronic Active   |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  41                                                               
NTP Experiment-Test: 05061-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 11:03:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 5| 7| 7| 7| 6| 2| 7| 7| 7| 6| 6| 7| 7| 6| 6| 2|              |            |
                             DAY ON TEST   | 2| 2| 1| 0| 7| 3| 3| 0| 9| 7| 3| 3| 2| 4| 0| 2| 2| 6| 4| 8|              |            |
                                           | 9| 9| 4| 9| 5| 0| 0| 8| 5| 9| 0| 0| 5| 9| 1| 9| 9| 0| 7| 1|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      A     |
    0.5%                                   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|              |      L     |
    71MLF                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Infarct                              |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Fibrosis                             |                                                                          |      2  1.0|
      Hemorrhage                           |                                                                          |      1  1.0|
      Infiltration Cellular, Histiocyte    | 1  1  1  1  1  1  1  1  1        1     1  1  1     1     1               |     53  1.0|
      Inflammation, Chronic Active         |                                                                          |      3  1.0|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      1  1.0|
      Artery, Mineralization               | 1     1              1                    1     1                        |     23  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Foreign Body                         | 1                                                     2                  |      4  1.8|
      Inflammation, Chronic Active         | 1        4                                2           3                  |     13  2.3|
      Metaplasia, Squamous                 |          3                                                               |      4  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                +                                                         |   8        |
      External Ear, Inflammation, Acute    |                                                                          |      2  3.0|
      Internal Ear, Inflammation, Acute    |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Eye                                     |                                           +  +                           |   7        |
      Phthisis Bulbi                       |                                                                          |      1  4.0|
      Lens, Cataract                       |                                           2                              |      1  2.0|
      Retina, Degeneration                 |                                           3  4                           |      3  3.3|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Abscess                              |                                                                          |      1  2.0|
      Autolysis                            |                                                                          |      3  2.7|
      Cyst                                 |                                                                          |      2  1.5|
      Fibrosis                             |                                     2                                    |      1  2.0|
      Hydronephrosis                       |                                                                          |      2  2.0|
      Infiltration Cellular, Mononuclear   |                                                                          |            |
          Cell                             |                                                          1               |      7  1.0|
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  42                                                               
NTP Experiment-Test: 05061-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 11:03:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 5| 7| 7| 7| 6| 2| 7| 7| 7| 6| 6| 7| 7| 6| 6| 2|              |            |
                             DAY ON TEST   | 2| 2| 1| 0| 7| 3| 3| 0| 9| 7| 3| 3| 2| 4| 0| 2| 2| 6| 4| 8|              |            |
                                           | 9| 9| 4| 9| 5| 0| 0| 8| 5| 9| 0| 0| 5| 9| 1| 9| 9| 0| 7| 1|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      A     |
    0.5%                                   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|              |      L     |
    71MLF                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Nephropathy                          | 3  3  3  2  2  3  3  2  3     3  3  4  2  3  3  3  2  3                  |     60  2.7|
      Pigmentation                         |                                                                          |      1  2.0|
      Artery, Thrombosis                   |                                                                          |      1  4.0|
      Pelvis, Inflammation, Chronic Active |                                     3                                    |      4  2.5|
      Pelvis, Metaplasia, Squamous         |                                     3                                    |      3  3.0|
      Renal Tubule, Hyperplasia            | 3  3                          2  3  4  3  4     3                        |     23  2.7|
      Renal Tubule, Hyperplasia, Oncocytic |                                                                          |      1  4.0|
      Renal Tubule, Inflammation, Acute    |                                                                          |      3  1.0|
      Renal Tubule, Inflammation, Chronic  |                                                                          |            |
          Active                           |                                     1                                    |      2  1.0|
      Renal Tubule, Pigmentation           | 2  2  2  1  2  2  2  3  2  2  2  2  2  2  2  2  2  2  2  2               |     70  2.0|
      Renal Tubule, Regeneration           |                            1                             1               |      7  1.0|
      Transitional Epithelium, Hyperplasia |       1  1     2  1  1           1  4     2  4  1                        |     44  1.5|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Autolysis                            |                                                                          |      2  3.0|
      Fibrosis                             |                1                                                         |      1  1.0|
      Hyperplasia, Lymphoid                |                                  1                                       |      3  1.3|
      Inflammation, Chronic Active         |          1                                                               |      3  1.0|
      Fat, Proliferation                   | 2        3                                                               |      4  2.3|
      Transitional Epithelium, Hyperplasia | 3  2     4  1  2     2  2     2  3  3     1     2                        |     41  2.0|
      Transitional Epithelium, Metaplasia, |                                                                          |            |
           Squamous                        |                                     2                                    |      4  2.3|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  43                                                               
NTP Experiment-Test: 05061-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 11:03:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 5| 2| 7| 7| 7| 6| 4| 7| 6| 6| 4| 4| 7| 7| 6| 5| 4| 7| 6| 6| 5| 4|             
                             DAY ON TEST   | 2| 2| 9| 6| 7| 2| 2| 0| 1| 6| 2| 8| 6| 6| 6| 2| 2| 7| 6| 1| 0| 3| 1| 8| 6|             
                                           | 9| 9| 5| 6| 9| 9| 9| 2| 6| 4| 0| 5| 2| 2| 2| 9| 2| 4| 9| 8| 2| 8| 0| 0| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    1.0%                                   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    71MHF                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +     +  +  +        +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +     +  +  +        +  +  +  +  +  +  +  +  +   |             
      Autolysis                            |                      2                                      3            |             
      Parasite Metazoan                    |       1        1                                               1         |             
      Lymphoid Tissue, Hemorrhage          |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Diverticulum                         |                                                                          |             
      Inflammation, Acute, Necrotizing     |                   2                                                      |             
      Parasite Metazoan                    |          1     1           1                          1        1         |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +     +  +  +        +  +  +  +  +  +  +  +  A   |             
      Autolysis                            |                      3                                      4            |             
      Parasite Metazoan                    |       1                                                                  |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +     +  +  +        +  +  +  +  +  +  +  +  +   |             
      Autolysis                            |                      2                                                   |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +     +  +  +        +  +  +  +  +  +  +  +  A   |             
      Autolysis                            |                      3                                      4            |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  M  +     +  +  +        +  +  +  +  +  +  +  +  A   |             
      Autolysis                            | 2                                                           4            |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                                          |             
      Basophilic Focus                     |                            1              3  1           2     2        1|             
      Clear Cell Focus                     |          2        1     3                 1                    1         |             
      Developmental Malformation           |                                                                          |             
      Eosinophilic Focus                   |                                              4                           |             
      Fatty Change                         |                            1        1     1        3        1           1|             
      Hematopoietic Cell Proliferation     | 1                                                        1               |             
      Hemorrhage                           |                                                                          |             
      Hepatodiaphragmatic Nodule           |                                                                          |             
      Inflammation, Chronic, Granulomatous |                            1           1  2                              |             
      Inflammation, Chronic Active         |          1                                   1                           |             
      Mixed Cell Focus                     |                1                             1                           |             
      Necrosis, Coagulative                |                                  4           1           1        2  3   |             
      Pigmentation                         | 1  2  1  1  1  1  1  1     1  1  1  1  1  1  1  1  1  1  1     1  1  1  1|             
      Thrombosis                           |                                                                          |             
      Bile Duct, Hyperplasia               |    2     1     1  1  2  1  1  1  1  2  1  1  2  1  1  1     2  3  2     1|             
      Periportal, Inflammation, Chronic    |                            1           1  1                             2|             
      Periportal, Inflammation, Chronic    |                                                                          |             
          Active                           |          1  1  1  1     1     1  1           1  1  1  1     1  1  2  1   |             
                                            __________________________________________________________________________|             
   Mesentery                               | +  +        M                                                            |             
      Fibrosis                             |    2                                                                     |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         |    1                                                                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  44                                                               
NTP Experiment-Test: 05061-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 11:03:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 5| 2| 7| 7| 7| 6| 4| 7| 6| 6| 4| 4| 7| 7| 6| 5| 4| 7| 6| 6| 5| 4|             
                             DAY ON TEST   | 2| 2| 9| 6| 7| 2| 2| 0| 1| 6| 2| 8| 6| 6| 6| 2| 2| 7| 6| 1| 0| 3| 1| 8| 6|             
                                           | 9| 9| 5| 6| 9| 9| 9| 2| 6| 4| 0| 5| 2| 2| 2| 9| 2| 4| 9| 8| 2| 8| 0| 0| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    1.0%                                   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    71MHF                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Pigmentation                         |                                                                          |             
      Polyarteritis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +   |             
      Atrophy                              | 1  1           1        2                       1     2        1         |             
      Autolysis                            |                                                                          |             
      Cytoplasmic Alteration               |                                  2                                       |             
      Infiltration Cellular, Mononuclear   |                                                                          |             
          Cell                             |                                                                          |             
      Inflammation, Chronic                |                                           1                              |             
      Inflammation, Chronic Active         |    1  1        1        1                       1     1     1  1         |             
      Vacuolization Cytoplasmic            |                                                                          |             
      Acinus, Hyperplasia                  |       1                                                                  |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                                                          |             
      Hemorrhage                           |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +     +  +  +        +  +  +  +  +  +  +  +  +   |             
      Infiltration Cellular, Mononuclear   |                                                                          |             
          Cell                             |                                                                          |             
      Parotid Gland, Inflammation, Chronic |                                                                          |             
          Active                           |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                                 4                        |             
      Erosion                              |                                                 3                        |             
      Hyperkeratosis                       | 1  3  3           2  2  2     1  1  2           2  2  2           2      |             
      Hyperplasia, Basal Cell              |    2  2           2  2  1        1  1           1  2  2     3            |             
      Hyperplasia, Squamous                | 3  4  4           4  2  3     3  2  4           3  4  2     4     3      |             
      Inflammation, Chronic                |                                        1                                 |             
      Inflammation, Chronic Active         | 1                    2  2                                         4      |             
      Ulcer                                |    3  2  3        3           3  3  4              3        2     4      |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Inflammation, Chronic Active         |    1              1     1                             3                  |             
      Necrosis, Coagulative                |                                                                          |             
      Ulcer                                |                                                       4                  |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
      Foreign Body                         |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +     +  +  +        +  +  +  +  +  +  +  +  +   |             
      Cardiomyopathy                       | 1  1  1        1  1  1  1     1  1  2        1  1  1     1  1  1  1  2   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +     +  +  +        +  +  +  +  +  +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  45                                                               
NTP Experiment-Test: 05061-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 11:03:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 5| 2| 7| 7| 7| 6| 4| 7| 6| 6| 4| 4| 7| 7| 6| 5| 4| 7| 6| 6| 5| 4|             
                             DAY ON TEST   | 2| 2| 9| 6| 7| 2| 2| 0| 1| 6| 2| 8| 6| 6| 6| 2| 2| 7| 6| 1| 0| 3| 1| 8| 6|             
                                           | 9| 9| 5| 6| 9| 9| 9| 2| 6| 4| 0| 5| 2| 2| 2| 9| 2| 4| 9| 8| 2| 8| 0| 0| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    1.0%                                   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    71MHF                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Angiectasis                          | 2  1     2        2  1  1     2     2        1                    1      |             
      Autolysis                            |                                                             2        3   |             
      Hyperplasia                          |                                                 1                        |             
      Vacuolization Cytoplasmic            | 2  1                                2        1     2  1           1      |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +     +  +  +        +  +  +  +  +  +  +  +  +   |             
      Autolysis                            |                                                                      3   |             
      Hyperplasia                          |    1  1        1     1        1     2           1  1                     |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +     +  +  M        +  M  +  M  +  +  +  M  M   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  M  +  +     M  +  +        +  +  +  +  +  +  +  +  +   |             
      Pars Distalis, Autolysis             |                                                                          |             
      Pars Distalis, Cyst                  |       2              2                             2  1           2  1   |             
      Pars Distalis, Cyst, Multiple        |    2                                         1                           |             
      Pars Distalis, Hyperplasia           |       1                                      2     1           1  1      |             
      Pars Distalis, Necrosis, Coagulative |                                                                          |             
      Rathke's Cleft, Cyst                 |          2                                                               |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +     +  +  +        +  +  +  +  +  +  +  +  +   |             
      Autolysis                            |                      3                                      3            |             
      C-Cell, Hyperplasia                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Abscess                              |                                                                          |             
      Inflammation, Chronic                |                            1           1  1                              |             
      Inflammation, Chronic Active         |    2     1     3  1     1                       1  1     1  1  1         |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  M  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Cyst                                 |                                                                4        4|             
      Periovarian Tissue, Cyst             |                                        4                                4|             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  M  +     +  +  +     +  +  +  +  +  +  +  +  +  +   |             
      Autolysis                            |                                                                          |             
      Cyst                                 |                               4     4                                    |             
      Fibrosis                             |                                                                          |             
      Hydrometra                           |                   2     1                 4  3                           |             
      Inflammation, Chronic Active         |                                     4                                    |             
      Endometrium, Hyperplasia             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +     +  +  +        +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +        M                       +     +     +     +                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  46                                                               
NTP Experiment-Test: 05061-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 11:03:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 5| 2| 7| 7| 7| 6| 4| 7| 6| 6| 4| 4| 7| 7| 6| 5| 4| 7| 6| 6| 5| 4|             
                             DAY ON TEST   | 2| 2| 9| 6| 7| 2| 2| 0| 1| 6| 2| 8| 6| 6| 6| 2| 2| 7| 6| 1| 0| 3| 1| 8| 6|             
                                           | 9| 9| 5| 6| 9| 9| 9| 2| 6| 4| 0| 5| 2| 2| 2| 9| 2| 4| 9| 8| 2| 8| 0| 0| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    1.0%                                   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    71MHF                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Pigmentation                         |                                                                          |             
      Iliac, Infiltration Cellular,        |                                                                          |             
          Histiocyte                       |                                                                          |             
      Lumbar, Hemorrhage                   |                                                                          |             
      Lumbar, Infiltration Cellular,       |                                                                          |             
          Histiocyte                       |    2                                                                     |             
      Lumbar, Pigmentation                 |                                                                          |             
      Mediastinal, Hemorrhage              |                                                                          |             
      Mediastinal, Infiltration Cellular,  |                                                                          |             
           Histiocyte                      | 2                                                                        |             
      Mediastinal, Pigmentation            |                                                                          |             
      Pancreatic, Hemorrhage               |                                                                          |             
      Pancreatic, Hyperplasia              |                                                                          |             
      Pancreatic, Infiltration Cellular,   |                                                                          |             
           Histiocyte                      |                                           3     2     2                  |             
      Pancreatic, Pigmentation             |                                           1                              |             
      Renal, Hemorrhage                    |                                                                          |             
      Renal, Infiltration Cellular,        |                                                                          |             
          Histiocyte                       |                                                                          |             
      Renal, Pigmentation                  |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  M  +  +  +  +     +  +  +        +  M  M  +  +  +  +  +  +   |             
      Autolysis                            |                                                                          |             
      Depletion Lymphoid                   |       3                                                                  |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia                          |                               2                                          |             
      Infiltration Cellular, Histiocyte    |          1     1                 1  1                       1            |             
      Inflammation, Chronic Active         |                               1                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  M  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Autolysis                            |                                                             3            |             
      Depletion Lymphoid                   | 2                    3        2                                          |             
      Hemorrhage                           |             2                             2                              |             
      Infiltration Cellular, Histiocyte    | 1     1  1  1  1  2  1  1     1  1     1  2  2  1  1  1  1  1  1  1  1   |             
      Pigmentation                         |                                        1  2                              |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +     +  +  +        +  +  +  +  +  +  +  +  +   |             
      Autolysis                            |                                                                          |             
      Congestion                           |                                                                          |             
      Depletion Lymphoid                   |             1        2                                               2   |             
      Fibrosis                             |                               2                                          |             
      Hematopoietic Cell Proliferation     |                               2                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  M  +  +  M  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                         2|             
      Depletion Lymphoid                   |                            2           1                                2|             
      Hemorrhage                           |                                                                          |             
      Pigmentation                         |                                                                         2|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  47                                                               
NTP Experiment-Test: 05061-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 11:03:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 5| 2| 7| 7| 7| 6| 4| 7| 6| 6| 4| 4| 7| 7| 6| 5| 4| 7| 6| 6| 5| 4|             
                             DAY ON TEST   | 2| 2| 9| 6| 7| 2| 2| 0| 1| 6| 2| 8| 6| 6| 6| 2| 2| 7| 6| 1| 0| 3| 1| 8| 6|             
                                           | 9| 9| 5| 6| 9| 9| 9| 2| 6| 4| 0| 5| 2| 2| 2| 9| 2| 4| 9| 8| 2| 8| 0| 0| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    1.0%                                   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    71MHF                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  M  M  +  +  +  M  +  +     +  +  +        +  +  +  +  +  +  +  +  +   |             
      Hyperplasia                          | 2                    1        1  1  1        1  1        2  1  2     2   |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +     +  +  +        +  +  +  +  +  +  +  +  +   |             
      Abscess                              |                                                                          |             
      Inflammation, Chronic Active         |                               3                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +     +  +  +        +  +  +  +  +  +  +  +  +   |             
      Cranium, Osteopetrosis               |                               2                                          |             
      Femur, Osteopetrosis                 |                               4                                          |             
      Sternum, Osteopetrosis               |                               4                                      3   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +     +  +  +        +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Histiocyte    |    1  1  1     1  1  1     1  1  1  1  1        1  1  1  1     1  1  1  1|             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Polyarteritis                        |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Artery, Mineralization               |    1                    1  1           1     1           1               |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +     +  +  +        +  +  +  +  +  +  +  +  +   |             
      Autolysis                            |                                                                          |             
      Inflammation, Chronic Active         | 2                                                     1        1     3   |             
      Metaplasia, Squamous                 |                                                                          |             
      Arteriole, Thrombosis                |                                  2                                       |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +     +  +  +        +  +  +  +  +  +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     | +                                                                        |             
                                            __________________________________________________________________________|             
   Eye                                     |                +     +        +                                          |             
      Synechia                             |                      4                                                   |             
      Cornea, Inflammation, Acute          |                      1                                                   |             
      Retina, Degeneration                 |                      4                                                   |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                             3        3   |             
      Infiltration Cellular, Mononuclear   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  48                                                               
NTP Experiment-Test: 05061-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 11:03:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 5| 2| 7| 7| 7| 6| 4| 7| 6| 6| 4| 4| 7| 7| 6| 5| 4| 7| 6| 6| 5| 4|             
                             DAY ON TEST   | 2| 2| 9| 6| 7| 2| 2| 0| 1| 6| 2| 8| 6| 6| 6| 2| 2| 7| 6| 1| 0| 3| 1| 8| 6|             
                                           | 9| 9| 5| 6| 9| 9| 9| 2| 6| 4| 0| 5| 2| 2| 2| 9| 2| 4| 9| 8| 2| 8| 0| 0| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    1.0%                                   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    71MHF                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
          Cell                             |                                                                          |             
      Nephropathy                          | 3  4  2  2     2  2  3  3  2  3  4  3  3  2  2  3  2  3  2  2  3  3  2  4|             
      Papilla, Necrosis, Coagulative       |                                                                          |             
      Pelvis, Inflammation, Chronic Active |    3                             3                                       |             
      Pelvis, Metaplasia, Squamous         |                                  4                                       |             
      Renal Tubule, Hyperplasia            | 3  4              2           3  3     1     2  4  3  4     3  3         |             
      Renal Tubule, Inflammation, Chronic  |                                                                          |             
          Active                           | 1              1                 1              1                        |             
      Renal Tubule, Pigmentation           | 2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  1  2  2  2  2  2  2|             
      Renal Tubule, Regeneration           |                                                                          |             
      Transitional Epithelium, Hyperplasia |    4  2                       1     1  1  1  1  1  1              1     4|             
      Transitional Epithelium,             |                                                                          |             
          Mineralization                   |                                           1                              |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calculus Gross Observation           |                                                                   X      |             
      Calculus Micro Observation Only      |                                                                          |             
      Hemorrhage                           |                                                                      1   |             
      Infiltration Cellular, Mononuclear   |                                                                          |             
          Cell                             |                                                                          |             
      Inflammation, Chronic                |                                                                         2|             
      Inflammation, Chronic Active         |                                                                          |             
      Necrosis                             |                                                                          |             
      Fat, Proliferation                   |                                                                          |             
      Transitional Epithelium, Hyperplasia |    1  2  3     3  1     2  3  2  1  2     2  3  2  3  1  3     3  3     4|             
      Transitional Epithelium,             |                                                                          |             
          Infiltration Cellular,           |                                                                          |             
          Mononuclear Cell                 |                                                                          |             
      Transitional Epithelium, Metaplasia, |                                                                          |             
           Squamous                        |          4                          1                                    |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  49                                                               
NTP Experiment-Test: 05061-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 11:03:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 5| 2| 7| 7| 6| 6| 2| 7| 7| 5| 4| 0| 6| 4| 4| 2| 2| 7| 7| 7| 6| 5|             
                             DAY ON TEST   | 3| 3| 2| 4| 8| 2| 2| 3| 1| 8| 2| 1| 9| 6| 4| 5| 6| 6| 7| 7| 2| 1| 0| 0| 5|             
                                           | 6| 6| 5| 3| 1| 9| 9| 5| 4| 1| 9| 4| 8| 4| 2| 8| 2| 2| 9| 9| 9| 5| 5| 0| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    1.0%                                   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    71MHF                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  M  +  +  +  +  +  +  +        +        +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  M  +  +  +  +  +        +        +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Parasite Metazoan                    |                                                             1            |             
      Lymphoid Tissue, Hemorrhage          |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  M  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Diverticulum                         |                                                                          |             
      Inflammation, Acute, Necrotizing     |                                     1                                    |             
      Parasite Metazoan                    |                                                             1            |             
      Ulcer                                | 3                                                                        |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  M  +  +  +  +  +        +        +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  M  +  +  +  M  +  +  +  +  +        +        +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  M  +  +  +  +  +        +        +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  M  M  +  +  +  +        +        +  +  +  +  +  +  +|             
      Autolysis                            |                                                                   2      |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  M  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                        2                                 |             
      Basophilic Focus                     |    1     2        1     2           1  1     1  1  1        1        2  1|             
      Clear Cell Focus                     | 2  1              1     2           1  2                 1  2        2  1|             
      Developmental Malformation           |                                                                          |             
      Eosinophilic Focus                   |                                                                          |             
      Fatty Change                         |                                        2        1  1           2         |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Hepatodiaphragmatic Nodule           |                                        X                                 |             
      Inflammation, Chronic, Granulomatous |                                        1           1                     |             
      Inflammation, Chronic Active         |             1                                                            |             
      Mixed Cell Focus                     |                               2                                         3|             
      Necrosis, Coagulative                |    1        1           2  1                    1  1                     |             
      Pigmentation                         | 1  1     1  1  1  1     2  1  2  1  1  1     1  1  1  1     1  1  2  1  1|             
      Thrombosis                           |                                  2                                       |             
      Bile Duct, Hyperplasia               | 1  1     2     2  2     2     2  1  1  1     1  1  1        1  2  2  2  1|             
      Periportal, Inflammation, Chronic    |                                        1        1  1                     |             
      Periportal, Inflammation, Chronic    |                                                                          |             
          Active                           | 1  1     1     1  1     1  1  2  1  1        1        1  1  1  2  1  1  1|             
                                            __________________________________________________________________________|             
   Mesentery                               |             M              M        +                 M  M        +      |             
      Fibrosis                             |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  50                                                               
NTP Experiment-Test: 05061-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 11:03:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 5| 2| 7| 7| 6| 6| 2| 7| 7| 5| 4| 0| 6| 4| 4| 2| 2| 7| 7| 7| 6| 5|             
                             DAY ON TEST   | 3| 3| 2| 4| 8| 2| 2| 3| 1| 8| 2| 1| 9| 6| 4| 5| 6| 6| 7| 7| 2| 1| 0| 0| 5|             
                                           | 6| 6| 5| 3| 1| 9| 9| 5| 4| 1| 9| 4| 8| 4| 2| 8| 2| 2| 9| 9| 9| 5| 5| 0| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    1.0%                                   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    71MHF                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Pigmentation                         |                                                                          |             
      Polyarteritis                        |                                     4                                    |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  M  +  +  +  +  +        +        +  +  +  +  M  +  +|             
      Atrophy                              |                1                    3                       1           2|             
      Autolysis                            |                                                                          |             
      Cytoplasmic Alteration               |                                                                          |             
      Infiltration Cellular, Mononuclear   |                                                                          |             
          Cell                             |                                                          1               |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         | 1     1  1     1        1           2        1              1           1|             
      Vacuolization Cytoplasmic            |                               1  1                                       |             
      Acinus, Hyperplasia                  |                                                                          |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                                                          |             
      Hemorrhage                           |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +        +        +  +  +  +  +  +  +|             
      Infiltration Cellular, Mononuclear   |                                                                          |             
          Cell                             |                                                                          |             
      Parotid Gland, Inflammation, Chronic |                                                                          |             
          Active                           |                               1                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  M  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                                                          |             
      Erosion                              |                                                                   3      |             
      Hyperkeratosis                       | 2     2        1  2     3     1  2                          1  2  2     2|             
      Hyperplasia, Basal Cell              | 1     2  2     1  4     2     4  2                             2  2  2  2|             
      Hyperplasia, Squamous                | 3     3        3  3     3     2  3           1              2  3  3  3  2|             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         |       1                 2                                   3        3   |             
      Ulcer                                | 3                 2              4                             2  2      |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  M  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Inflammation, Chronic Active         |                                     3                                    |             
      Necrosis, Coagulative                |                                                                          |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                         +|             
      Foreign Body                         |                                                                         1|             
      Inflammation, Chronic                |                                                                         2|             
                                            __________________________________________________________________________|             
   Tooth                                   |                   +                                                      |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +        +        +  +  +  +  +  +  +|             
      Cardiomyopathy                       |    2  1  1     1  1           2  1  1        1        1  1  1  1     1   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  M  +  +  +  +  +        +        +  +  M  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  51                                                               
NTP Experiment-Test: 05061-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 11:03:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 5| 2| 7| 7| 6| 6| 2| 7| 7| 5| 4| 0| 6| 4| 4| 2| 2| 7| 7| 7| 6| 5|             
                             DAY ON TEST   | 3| 3| 2| 4| 8| 2| 2| 3| 1| 8| 2| 1| 9| 6| 4| 5| 6| 6| 7| 7| 2| 1| 0| 0| 5|             
                                           | 6| 6| 5| 3| 1| 9| 9| 5| 4| 1| 9| 4| 8| 4| 2| 8| 2| 2| 9| 9| 9| 5| 5| 0| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    1.0%                                   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    71MHF                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Angiectasis                          | 2        1     2  1     1     1  1  1                             2  2  1|             
      Autolysis                            |                                                                          |             
      Hyperplasia                          |                                                                          |             
      Vacuolization Cytoplasmic            |    1           1  1           1  2                             2  1  2   |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  M  +  +  +  +  +        +        +  +  M  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Hyperplasia                          |       2        1                 1           1                 1         |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +     +  +  M  +     +  +  +        +              +  +  M  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  M  +  +  M  +  +        +        +  +  M  +  +  +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +        +        +  +  +  +  +  +  +|             
      Pars Distalis, Autolysis             |                      3                                                   |             
      Pars Distalis, Cyst                  |       1        1        2     2  2                                       |             
      Pars Distalis, Cyst, Multiple        |                                                                2         |             
      Pars Distalis, Hyperplasia           |                                                             1            |             
      Pars Distalis, Necrosis, Coagulative |                                                                   1      |             
      Rathke's Cleft, Cyst                 |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +        +        +  +  +  +  +  +  +|             
      Autolysis                            |                      3                                                   |             
      C-Cell, Hyperplasia                  |                                                                   1      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  M  +  +  +  +  +        +        +  +  +  +  +  +  +|             
      Abscess                              |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         | 1  1  1  1     1  1     1     1  1  1                       1  1  1  1  1|             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  M  +  +  +  +  +        +     +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Cyst                                 |    4  1                                                                  |             
      Periovarian Tissue, Cyst             |                                                    4                     |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  M  +  +  +  +  +        +        +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Cyst                                 |                                                                          |             
      Fibrosis                             |                   3                                                      |             
      Hydrometra                           |          2  1                                         1  1               |             
      Inflammation, Chronic Active         |                                                                          |             
      Endometrium, Hyperplasia             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +        +        +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |       +     +              M  +                 +  +  +  +  +     +  +   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  52                                                               
NTP Experiment-Test: 05061-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 11:03:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 5| 2| 7| 7| 6| 6| 2| 7| 7| 5| 4| 0| 6| 4| 4| 2| 2| 7| 7| 7| 6| 5|             
                             DAY ON TEST   | 3| 3| 2| 4| 8| 2| 2| 3| 1| 8| 2| 1| 9| 6| 4| 5| 6| 6| 7| 7| 2| 1| 0| 0| 5|             
                                           | 6| 6| 5| 3| 1| 9| 9| 5| 4| 1| 9| 4| 8| 4| 2| 8| 2| 2| 9| 9| 9| 5| 5| 0| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    1.0%                                   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    71MHF                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Pigmentation                         |             1                                                            |             
      Iliac, Infiltration Cellular,        |                                                                          |             
          Histiocyte                       |                                                                      1   |             
      Lumbar, Hemorrhage                   |                                                                          |             
      Lumbar, Infiltration Cellular,       |                                                                          |             
          Histiocyte                       |                                                                          |             
      Lumbar, Pigmentation                 |                                                                          |             
      Mediastinal, Hemorrhage              |                                                          1               |             
      Mediastinal, Infiltration Cellular,  |                                                                          |             
           Histiocyte                      |                                                                          |             
      Mediastinal, Pigmentation            |                                                                          |             
      Pancreatic, Hemorrhage               |                                                       2                  |             
      Pancreatic, Hyperplasia              |                                                                          |             
      Pancreatic, Infiltration Cellular,   |                                                                          |             
           Histiocyte                      |       2                       2                 2  4        3            |             
      Pancreatic, Pigmentation             |                                                 2  2  1                  |             
      Renal, Hemorrhage                    |             1                                                            |             
      Renal, Infiltration Cellular,        |                                                                          |             
          Histiocyte                       |             3                                                            |             
      Renal, Pigmentation                  |             1                                                            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  M  +  +  +  +  M  +  +  +  +  +        +        M  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Depletion Lymphoid                   |                                                                          |             
      Hemorrhage                           |             1              1                                             |             
      Hyperplasia                          |                                                                          |             
      Infiltration Cellular, Histiocyte    |                                  1                                       |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  M  +  +  +  +  +  +     +        +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Depletion Lymphoid                   |                2                                                  3      |             
      Hemorrhage                           |                                                          3               |             
      Infiltration Cellular, Histiocyte    | 1  1  1  1  3  1  1     1  1  1  2  1  1     1        2  1  1  1  1  1  2|             
      Pigmentation                         |                                        1                                 |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  M  +  +  +  +  +        +        +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Congestion                           |                                                                          |             
      Depletion Lymphoid                   |             2     1                                            1         |             
      Fibrosis                             |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  M  +  +  +  M  +  +     +  +  +  +  +  +  +  +  M  M|             
      Cyst                                 |                                                                          |             
      Depletion Lymphoid                   |                                                    3                     |             
      Hemorrhage                           |                                                                          |             
      Pigmentation                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  53                                                               
NTP Experiment-Test: 05061-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 11:03:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 5| 2| 7| 7| 6| 6| 2| 7| 7| 5| 4| 0| 6| 4| 4| 2| 2| 7| 7| 7| 6| 5|             
                             DAY ON TEST   | 3| 3| 2| 4| 8| 2| 2| 3| 1| 8| 2| 1| 9| 6| 4| 5| 6| 6| 7| 7| 2| 1| 0| 0| 5|             
                                           | 6| 6| 5| 3| 1| 9| 9| 5| 4| 1| 9| 4| 8| 4| 2| 8| 2| 2| 9| 9| 9| 5| 5| 0| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    1.0%                                   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    71MHF                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  M  +  M  +  +  M  +  +  M  +  +        +        M  M  +  +  M  +  +|             
      Hyperplasia                          |          1     1  2              1  2        2              1  2         |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +        +  +  +  +  +  +  +|             
      Abscess                              |                                     3                                    |             
      Inflammation, Chronic Active         |                      1                                                   |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +        +        +  +  +  +  +  +  +|             
      Cranium, Osteopetrosis               |                                                                          |             
      Femur, Osteopetrosis                 |                                                                          |             
      Sternum, Osteopetrosis               |                      2                                                   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +        +        +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +        +     +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Histiocyte    | 1  1  1  1        1           1  1  1              1  1     1  1     1   |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic Active         |                                                                         2|             
      Polyarteritis                        |                                     4                                    |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Artery, Mineralization               |                      1     1        1        1                    1      |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +        +        +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Inflammation, Chronic Active         |                                     2                          1  4      |             
      Metaplasia, Squamous                 |                                                                          |             
      Arteriole, Thrombosis                |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +        +        +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                +                                                         |             
                                            __________________________________________________________________________|             
   Eye                                     |       +           +                                               +      |             
      Synechia                             |                                                                          |             
      Cornea, Inflammation, Acute          |                                                                          |             
      Retina, Degeneration                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  M  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Infiltration Cellular, Mononuclear   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  54                                                               
NTP Experiment-Test: 05061-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 11:03:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 5| 2| 7| 7| 6| 6| 2| 7| 7| 5| 4| 0| 6| 4| 4| 2| 2| 7| 7| 7| 6| 5|             
                             DAY ON TEST   | 3| 3| 2| 4| 8| 2| 2| 3| 1| 8| 2| 1| 9| 6| 4| 5| 6| 6| 7| 7| 2| 1| 0| 0| 5|             
                                           | 6| 6| 5| 3| 1| 9| 9| 5| 4| 1| 9| 4| 8| 4| 2| 8| 2| 2| 9| 9| 9| 5| 5| 0| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    1.0%                                   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    71MHF                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
          Cell                             |                                                       2                  |             
      Nephropathy                          | 2  3  3  3     3  3     3     3  3  2  2     3  2  2        3  3  3  2  2|             
      Papilla, Necrosis, Coagulative       |                                                                          |             
      Pelvis, Inflammation, Chronic Active |                               3                                          |             
      Pelvis, Metaplasia, Squamous         |                               3                                          |             
      Renal Tubule, Hyperplasia            | 2  2  1        4  3           4  2           2  1           3  3  3  1   |             
      Renal Tubule, Inflammation, Chronic  |                                                                          |             
          Active                           |                                  1                             1         |             
      Renal Tubule, Pigmentation           | 2  2  2  2  2  2  2     2  2  2  2  2  2     2  2  2  2  2  2  2  2  2  2|             
      Renal Tubule, Regeneration           |                                                       1                  |             
      Transitional Epithelium, Hyperplasia |    1  1           1           3  1  1              1                     |             
      Transitional Epithelium,             |                                                                          |             
          Mineralization                   |                                                          1               |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  M  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Calculus Gross Observation           |                                                                          |             
      Calculus Micro Observation Only      |                                              2                           |             
      Hemorrhage                           |                                     2                                    |             
      Infiltration Cellular, Mononuclear   |                                                                          |             
          Cell                             |                                                          1               |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         |                                     2                                    |             
      Necrosis                             |                                     2                                    |             
      Fat, Proliferation                   |                                                                      2   |             
      Transitional Epithelium, Hyperplasia | 3  2  2     2  2  2     3     2  2  4  3     3  2  3        3  1  1  4  2|             
      Transitional Epithelium,             |                                                                          |             
          Infiltration Cellular,           |                                                                          |             
          Mononuclear Cell                 |                                                          1               |             
      Transitional Epithelium, Metaplasia, |                                                                          |             
           Squamous                        | 4                       2        2  3                                    |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  55                                                               
NTP Experiment-Test: 05061-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 11:03:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 4| 2| 2| 7| 7| 6| 5| 5| 7| 6| 6| 4| 2| 4| 4| 3| 2| 2|              |            |
                             DAY ON TEST   | 1| 3| 6| 7| 7| 2| 2| 7| 7| 1| 2| 6| 6| 6| 7| 6| 6| 6| 8| 7|              |            |
                                           | 9| 7| 0| 9| 9| 9| 9| 3| 6| 2| 9| 4| 2| 2| 9| 4| 4| 7| 1| 9|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |      A     |
    1.0%                                   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|              |      L     |
    71MHF                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +     +        +  +  +               |  58        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | M  +  +  +  +  +  +  +  +  +  +  +  +     +        +  +  +               |  57        |
      Autolysis                            |                                     4                                    |      3  3.0|
      Parasite Metazoan                    |    1           1                                      1                  |      7  1.0|
      Lymphoid Tissue, Hemorrhage          |             2                                                            |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  67        |
      Autolysis                            |                                     3                                    |      1  3.0|
      Diverticulum                         |                                  1                                       |      1  1.0|
      Inflammation, Acute, Necrotizing     |                               2                                          |      3  1.7|
      Parasite Metazoan                    |    1              1           1                                          |      9  1.0|
      Ulcer                                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +     +        +  +  +               |  57        |
      Autolysis                            |       3                             4                                    |      4  3.5|
      Parasite Metazoan                    |                   1                                                      |      2  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  A     +        +  +  +               |  56        |
      Autolysis                            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  A     +        +  +  +               |  56        |
      Autolysis                            |       4                                                                  |      3  3.7|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  A     +        +  +  +               |  54        |
      Autolysis                            |       4                                                                  |      4  3.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  68        |
      Abscess                              |                                                                          |      1  2.0|
      Basophilic Focus                     |    1  2                 1  2           1     3  1     1                  |     26  1.4|
      Clear Cell Focus                     |    2              1     3  1  2        2     2  1                        |     23  1.6|
      Developmental Malformation           |          X                                                               |      1     |
      Eosinophilic Focus                   |                                                                          |      1  4.0|
      Fatty Change                         |             2                    2     1     1                           |     14  1.4|
      Hematopoietic Cell Proliferation     |                                                                          |      2  1.0|
      Hemorrhage                           |                         2                                                |      1  2.0|
      Hepatodiaphragmatic Nodule           |                                                                          |      1     |
      Inflammation, Chronic, Granulomatous |                                              1                           |      6  1.2|
      Inflammation, Chronic Active         |    1  1                    1              2                              |      7  1.1|
      Mixed Cell Focus                     |                                                                          |      4  1.8|
      Necrosis, Coagulative                |    1                       1           1  1  1        1                  |     17  1.4|
      Pigmentation                         | 1  1  1     1  1  1  1  1  2  2  1  1  2     1  1  1     1               |     61  1.1|
      Thrombosis                           |                                                                          |      1  2.0|
      Bile Duct, Hyperplasia               | 1  1  1     1  2  2  1  2  2  1  1  2  1  1  2  1        1               |     55  1.4|
      Periportal, Inflammation, Chronic    |                                        1     1  1                        |     10  1.1|
      Periportal, Inflammation, Chronic    |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  56                                                               
NTP Experiment-Test: 05061-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 11:03:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 4| 2| 2| 7| 7| 6| 5| 5| 7| 6| 6| 4| 2| 4| 4| 3| 2| 2|              |            |
                             DAY ON TEST   | 1| 3| 6| 7| 7| 2| 2| 7| 7| 1| 2| 6| 6| 6| 7| 6| 6| 6| 8| 7|              |            |
                                           | 9| 7| 0| 9| 9| 9| 9| 3| 6| 2| 9| 4| 2| 2| 9| 4| 4| 7| 1| 9|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |      A     |
    1.0%                                   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|              |      L     |
    71MHF                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
          Active                           | 1  1     1  1  1  2  1  1  2  1  1  1                 1  2               |     47  1.1|
                                            __________________________________________________________________________|____________|
   Mesentery                               |          M  M                             M  +        M  M               |   5        |
      Fibrosis                             |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                              4                           |      1  4.0|
      Inflammation, Chronic Active         |                                                                          |      1  1.0|
      Pigmentation                         |                                              3                           |      1  3.0|
      Polyarteritis                        |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +     +        +  +  +               |  58        |
      Atrophy                              |    1           1     3                             1                     |     15  1.5|
      Autolysis                            |                                     3                                    |      1  3.0|
      Cytoplasmic Alteration               |                                                                          |      1  2.0|
      Infiltration Cellular, Mononuclear   |                                                                          |            |
          Cell                             |                                                                          |      1  1.0|
      Inflammation, Chronic                |                                                                          |      1  1.0|
      Inflammation, Chronic Active         | 1  1           1  1  2                                                   |     22  1.1|
      Vacuolization Cytoplasmic            |                               1                                          |      3  1.0|
      Acinus, Hyperplasia                  |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Pharynx                                 |                                                 +                        |   1        |
      Hemorrhage                           |                                                 4                        |      1  4.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  M  +  +  +     +        +  +  +               |  58        |
      Infiltration Cellular, Mononuclear   |                                                                          |            |
          Cell                             |          1                                               1               |      2  1.0|
      Parotid Gland, Inflammation, Chronic |                                                                          |            |
          Active                           |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  67        |
      Cyst Epithelial Inclusion            |                                                                          |      1  4.0|
      Erosion                              | 2                                                                        |      3  2.7|
      Hyperkeratosis                       | 2              2  1              2                                       |     28  1.9|
      Hyperplasia, Basal Cell              | 2              2  2     2        1              2                        |     29  1.9|
      Hyperplasia, Squamous                | 3              4  3     3     4  3                                       |     33  3.0|
      Inflammation, Chronic                |                                                                          |      1  1.0|
      Inflammation, Chronic Active         |                   2              2                                       |     10  2.2|
      Ulcer                                |                4        3                                                |     17  2.9|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  68        |
      Autolysis                            |                                     2                                    |      1  2.0|
      Inflammation, Chronic Active         |                            1                                             |      6  1.7|
      Necrosis, Coagulative                |                      2                                                   |      1  2.0|
      Ulcer                                |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  57                                                               
NTP Experiment-Test: 05061-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 11:03:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 4| 2| 2| 7| 7| 6| 5| 5| 7| 6| 6| 4| 2| 4| 4| 3| 2| 2|              |            |
                             DAY ON TEST   | 1| 3| 6| 7| 7| 2| 2| 7| 7| 1| 2| 6| 6| 6| 7| 6| 6| 6| 8| 7|              |            |
                                           | 9| 7| 0| 9| 9| 9| 9| 3| 6| 2| 9| 4| 2| 2| 9| 4| 4| 7| 1| 9|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |      A     |
    1.0%                                   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|              |      L     |
    71MHF                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Foreign Body                         |                                                                          |      1  1.0|
      Inflammation, Chronic                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +     +        +  +  +               |  59        |
      Cardiomyopathy                       | 1  1  1        1  2  1     1  1  1  1                    1               |     43  1.1|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +  +               |  58        |
      Angiectasis                          | 1              1  1  1     1                                             |     26  1.3|
      Autolysis                            |                                     2                                    |      3  2.3|
      Hyperplasia                          |                                                                          |      1  1.0|
      Vacuolization Cytoplasmic            |    1              1  1           2           1                           |     20  1.4|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +  +               |  58        |
      Autolysis                            |                                                                          |      1  3.0|
      Hyperplasia                          |                   1                                                      |     14  1.1|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +        +  +  +  +  +  +  +  +              +                     |  47        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  M  +  +  +  +  M  +  +  +  +  +     +        +  +  +               |  48        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +     +        +  +  +               |  57        |
      Pars Distalis, Autolysis             |                                                                          |      1  3.0|
      Pars Distalis, Cyst                  |                1        1  1  2  1  2                    1               |     18  1.5|
      Pars Distalis, Cyst, Multiple        |                                                                          |      3  1.7|
      Pars Distalis, Hyperplasia           |                               2  2                                       |      8  1.4|
      Pars Distalis, Necrosis, Coagulative |                                                                          |      1  1.0|
      Rathke's Cleft, Cyst                 |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +     +        +  +  +               |  59        |
      Autolysis                            |                                     3                                    |      4  3.0|
      C-Cell, Hyperplasia                  |                                           2                              |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |             +                                                            |   1        |
      Hemorrhage                           |             2                                                            |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  M  M  +  +  +  +  +  +  +  +  +  +     +        +  +  +               |  58        |
      Abscess                              |                   2                                                      |      1  2.0|
      Inflammation, Chronic                |                                                                          |      3  1.0|
      Inflammation, Chronic Active         | 1              1     1     1  1     1                                    |     31  1.1|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  58                                                               
NTP Experiment-Test: 05061-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 11:03:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 4| 2| 2| 7| 7| 6| 5| 5| 7| 6| 6| 4| 2| 4| 4| 3| 2| 2|              |            |
                             DAY ON TEST   | 1| 3| 6| 7| 7| 2| 2| 7| 7| 1| 2| 6| 6| 6| 7| 6| 6| 6| 8| 7|              |            |
                                           | 9| 7| 0| 9| 9| 9| 9| 3| 6| 2| 9| 4| 2| 2| 9| 4| 4| 7| 1| 9|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |      A     |
    1.0%                                   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|              |      L     |
    71MHF                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +  +  +               |  61        |
      Congestion                           |                                                          1               |      1  1.0|
      Cyst                                 |                         2                       1                        |      6  2.7|
      Periovarian Tissue, Cyst             |                                                 2                        |      4  3.5|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +               |  60        |
      Autolysis                            |                                     3                                    |      1  3.0|
      Cyst                                 |                      2                                                   |      3  3.3|
      Fibrosis                             |                                                                          |      1  3.0|
      Hydrometra                           |                                           1  4  2        1               |     12  1.9|
      Inflammation, Chronic Active         |                                                                          |      1  4.0|
      Endometrium, Hyperplasia             |                               1                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +     +        +  +  +               |  59        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +     +  +     +     +                 M           +  +               |  24        |
      Pigmentation                         |                                                                          |      1  1.0|
      Iliac, Infiltration Cellular,        |                                                                          |            |
          Histiocyte                       |                                                                          |      1  1.0|
      Lumbar, Hemorrhage                   |          2                                                               |      1  2.0|
      Lumbar, Infiltration Cellular,       |                                                                          |            |
          Histiocyte                       |          2                                                               |      2  2.0|
      Lumbar, Pigmentation                 |          1                                                               |      1  1.0|
      Mediastinal, Hemorrhage              |             2                                         1                  |      3  1.3|
      Mediastinal, Infiltration Cellular,  |                                                                          |            |
           Histiocyte                      | 1                                                     1                  |      3  1.3|
      Mediastinal, Pigmentation            |          1                                            1                  |      2  1.0|
      Pancreatic, Hemorrhage               |          1                                               1               |      3  1.3|
      Pancreatic, Hyperplasia              |                   2                                                      |      1  2.0|
      Pancreatic, Infiltration Cellular,   |                                                                          |            |
           Histiocyte                      |    2              1     2                                                |     11  2.3|
      Pancreatic, Pigmentation             |                                                                          |      4  1.5|
      Renal, Hemorrhage                    |                                                                          |      1  1.0|
      Renal, Infiltration Cellular,        |                                                                          |            |
          Histiocyte                       |                                                                          |      1  3.0|
      Renal, Pigmentation                  |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +     +        +  +  +               |  53        |
      Autolysis                            |                                     2                                    |      1  2.0|
      Depletion Lymphoid                   |                                                                          |      1  3.0|
      Hemorrhage                           |          1                                               2               |      4  1.3|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  59                                                               
NTP Experiment-Test: 05061-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 11:03:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 4| 2| 2| 7| 7| 6| 5| 5| 7| 6| 6| 4| 2| 4| 4| 3| 2| 2|              |            |
                             DAY ON TEST   | 1| 3| 6| 7| 7| 2| 2| 7| 7| 1| 2| 6| 6| 6| 7| 6| 6| 6| 8| 7|              |            |
                                           | 9| 7| 0| 9| 9| 9| 9| 3| 6| 2| 9| 4| 2| 2| 9| 4| 4| 7| 1| 9|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |      A     |
    1.0%                                   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|              |      L     |
    71MHF                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia                          |                                                                          |      1  2.0|
      Infiltration Cellular, Histiocyte    |       1                 1  1                                             |      9  1.0|
      Inflammation, Chronic Active         |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | M  +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +  +               |  60        |
      Autolysis                            |                                     4                                    |      2  3.5|
      Depletion Lymphoid                   |                3     3                             2                     |      8  2.5|
      Hemorrhage                           |                                                                          |      3  2.3|
      Infiltration Cellular, Histiocyte    |    1  1  1  1  1  1  1  1  1  1  1  1     1  2     2  1  1               |     59  1.2|
      Pigmentation                         |                                              2                           |      4  1.5|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +     +        +  +  +               |  58        |
      Autolysis                            |                                     2                                    |      1  2.0|
      Congestion                           |                                                          2               |      1  2.0|
      Depletion Lymphoid                   |       1                                                                  |      7  1.4|
      Fibrosis                             |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  M  +  M  M  +  +  +  +  M  M  +  +  +  +  M  +  +  +  +               |  55        |
      Cyst                                 |                                                                          |      1  2.0|
      Depletion Lymphoid                   |                                                                          |      4  2.0|
      Hemorrhage                           |       2                                                                  |      1  2.0|
      Pigmentation                         |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  M  +  +  +  +  +  M  +  +     +        +  +  +               |  47        |
      Hyperplasia                          | 1              1  3  2     2     2  2                                    |     26  1.5|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +     +        +  +  +               |  60        |
      Abscess                              |                                                                          |      1  3.0|
      Inflammation, Chronic Active         |                                                                          |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +     +        +  +  +               |  59        |
      Cranium, Osteopetrosis               |                                                                          |      1  2.0|
      Femur, Osteopetrosis                 |                                                                          |      1  4.0|
      Sternum, Osteopetrosis               |                                                                          |      3  3.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +     +        +  +  +               |  59        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                         +                                                |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  60                                                               
NTP Experiment-Test: 05061-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 11:03:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 4| 2| 2| 7| 7| 6| 5| 5| 7| 6| 6| 4| 2| 4| 4| 3| 2| 2|              |            |
                             DAY ON TEST   | 1| 3| 6| 7| 7| 2| 2| 7| 7| 1| 2| 6| 6| 6| 7| 6| 6| 6| 8| 7|              |            |
                                           | 9| 7| 0| 9| 9| 9| 9| 3| 6| 2| 9| 4| 2| 2| 9| 4| 4| 7| 1| 9|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |      A     |
    1.0%                                   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|              |      L     |
    71MHF                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +  +  +               |  64        |
      Infiltration Cellular, Histiocyte    | 1  1  2     1  1  1     1  1  1  1              1                        |     43  1.0|
      Inflammation, Acute                  |                                                 1                        |      1  1.0|
      Inflammation, Chronic Active         |                      2                                                   |      2  2.0|
      Polyarteritis                        |                                                                          |      1  4.0|
      Alveolar Epithelium, Hyperplasia     |                                     2                                    |      1  2.0|
      Artery, Mineralization               |                1  1  1     1        1              2     1               |     18  1.1|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +     +        +  +  +               |  59        |
      Autolysis                            |                                     2                                    |      1  2.0|
      Inflammation, Chronic Active         | 1              2              2  4  3                                    |     12  2.2|
      Metaplasia, Squamous                 | 2                                2                                       |      2  2.0|
      Arteriole, Thrombosis                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +     +        +  +  +               |  59        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                   +                                                      |   3        |
                                            __________________________________________________________________________|____________|
   Eye                                     | +                                                                        |   7        |
      Synechia                             |                                                                          |      1  4.0|
      Cornea, Inflammation, Acute          |                                                                          |      1  1.0|
      Retina, Degeneration                 |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  68        |
      Autolysis                            |                                     2                                    |      3  2.7|
      Infiltration Cellular, Mononuclear   |                                                                          |            |
          Cell                             |             1                                         1                  |      3  1.3|
      Nephropathy                          | 3  2           3  3  3  2  3  2  2  2  3     3  2                        |     56  2.6|
      Papilla, Necrosis, Coagulative       |       4                    3                                             |      2  3.5|
      Pelvis, Inflammation, Chronic Active |                2     2                             2                     |      6  2.5|
      Pelvis, Metaplasia, Squamous         |                                                                          |      2  3.5|
      Renal Tubule, Hyperplasia            |                2        1     3  4           1                           |     30  2.6|
      Renal Tubule, Inflammation, Chronic  |                                                                          |            |
          Active                           |                                  1                                       |      7  1.0|
      Renal Tubule, Pigmentation           | 2  2  2  2  2  2  2  2  2  2  1  2  2  2  2  2  2  2  2  2               |     68  2.0|
      Renal Tubule, Regeneration           |                                           1           1  1               |      4  1.0|
      Transitional Epithelium, Hyperplasia | 1              4  1  3     2     1                 2                     |     25  1.6|
      Transitional Epithelium,             |                                                                          |            |
          Mineralization                   |                                                                          |      2  1.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +               |  66        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  61                                                               
NTP Experiment-Test: 05061-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 11:03:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 4| 2| 2| 7| 7| 6| 5| 5| 7| 6| 6| 4| 2| 4| 4| 3| 2| 2|              |            |
                             DAY ON TEST   | 1| 3| 6| 7| 7| 2| 2| 7| 7| 1| 2| 6| 6| 6| 7| 6| 6| 6| 8| 7|              |            |
                                           | 9| 7| 0| 9| 9| 9| 9| 3| 6| 2| 9| 4| 2| 2| 9| 4| 4| 7| 1| 9|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |      A     |
    1.0%                                   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|              |      L     |
    71MHF                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Calculus Gross Observation           |                                                                          |      1     |
      Calculus Micro Observation Only      |                                                                          |      1  2.0|
      Hemorrhage                           |                                                                          |      2  1.5|
      Infiltration Cellular, Mononuclear   |                                                                          |            |
          Cell                             |                                                                          |      1  1.0|
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Necrosis                             |                                                                          |      1  2.0|
      Fat, Proliferation                   |                            3                                             |      2  2.5|
      Transitional Epithelium, Hyperplasia | 2  2  1  1     1  3  3  2  4  2  3     2     2  2                        |     52  2.3|
      Transitional Epithelium,             |                                                                          |            |
          Infiltration Cellular,           |                                                                          |            |
          Mononuclear Cell                 |                                                                          |      1  1.0|
      Transitional Epithelium, Metaplasia, |                                                                          |            |
           Squamous                        |                      3                             4                     |      8  2.9|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  62                                                               
NTP Experiment-Test: 05061-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 11:03:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 2| 2| 4| 4| 0| 4| 3| 4| 4| 2| 2| 2| 4| 3| 2| 2| 2| 4| 4| 4| 4| 2|             
                             DAY ON TEST   | 6| 6| 2| 8| 7| 6| 6| 6| 6| 0| 6| 6| 9| 9| 7| 4| 1| 7| 7| 7| 6| 6| 6| 2| 7|             
                                           | 4| 2| 6| 1| 9| 4| 2| 5| 2| 6| 4| 4| 9| 4| 9| 1| 3| 9| 9| 9| 4| 4| 2| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    2.0%                                   | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    71HF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +     +  +  +  M  +  +  +  +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +     +  A  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Angiectasis                          |          1                                         2                     |             
      Basophilic Focus                     | 1  1     1  1  2  1     1     2  2           1              2  2     2   |             
      Clear Cell Focus                     | 2  1  1        2  1           1  1     1     1              1  1     1   |             
      Cytomegaly                           | 1                                                              1         |             
      Eosinophilic Focus                   |    2                                         1                           |             
      Fatty Change                         | 1                       1  1     2  1     2           1  1  1  1  1     1|             
      Hematopoietic Cell Proliferation     |                            1                                             |             
      Inflammation, Chronic, Granulomatous |    2                                                                     |             
      Inflammation, Chronic Active         |                                     1                                    |             
      Mixed Cell Focus                     |    1                    2                                         2      |             
      Necrosis, Coagulative                |    1     1  1              1        1     1        1        1           1|             
      Pigmentation                         | 1  1  1  1  1  1  2     2  1  1  1  1  1  2  1     1  1  1  2  1  2  1  1|             
      Bile Duct, Hyperplasia               | 2  2  1  1  1  2  2     2  1  2  2  1  1  1  2     1  1  1  2  1  1  1  1|             
      Periportal, Inflammation, Chronic    | 2  2           2  3     2     2  2                          2  2  2      |             
      Periportal, Inflammation, Chronic    |                                                                          |             
          Active                           |       1  1  2              1        1  1  1  1     2  1  2           1  2|             
                                            __________________________________________________________________________|             
   Mesentery                               |                                  +                                       |             
      Inflammation, Chronic, Granulomatous |                                  4                                       |             
      Necrosis, Coagulative                |                                  4                                       |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Atrophy                              |                1           1        1                    2               |             
      Ectopic Tissue                       |                1                                                         |             
      Infiltration Cellular, Mononuclear   |                                                                          |             
          Cell                             |                                                          1              2|             
      Inflammation, Chronic                |    1           1  1     1        1                          1            |             
      Inflammation, Chronic Active         |                            1                                         1   |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Duct, Submandibular Gland, Dilatation|                                                             3            |             
      Parotid Gland, Atrophy               |                               2                                          |             
      Parotid Gland, Inflammation, Chronic |                               1                                   1      |             
      Parotid Gland, Inflammation, Chronic |                                                                          |             
          Active                           |                                              1                       1   |             
      Submandibular Gland, Atrophy         |                                                             2            |             
      Submandibular Gland, Inflammation,   |                                                                          |             
           Chronic                         |                                                                1         |             
      Submandibular Gland, Inflammation,   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  63                                                               
NTP Experiment-Test: 05061-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 11:03:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 2| 2| 4| 4| 0| 4| 3| 4| 4| 2| 2| 2| 4| 3| 2| 2| 2| 4| 4| 4| 4| 2|             
                             DAY ON TEST   | 6| 6| 2| 8| 7| 6| 6| 6| 6| 0| 6| 6| 9| 9| 7| 4| 1| 7| 7| 7| 6| 6| 6| 2| 7|             
                                           | 4| 2| 6| 1| 9| 4| 2| 5| 2| 6| 4| 4| 9| 4| 9| 1| 3| 9| 9| 9| 4| 4| 2| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    2.0%                                   | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    71HF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
           Chronic Active                  |                            2        2        2              3        2   |             
      Submandibular Gland, Metaplasia,     |                                                                          |             
           Squamous                        |                            2                                         1   |             
      Submandibular Gland, Pigmentation    |                                                                   1      |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Acanthosis                           |                               1                                          |             
      Erosion                              |                                     2                                    |             
      Hyperkeratosis                       |                               1                                          |             
      Hyperplasia, Basal Cell              | 1  1                          1     1        1                           |             
      Hyperplasia, Squamous                |                                     2        2                           |             
      Ulcer                                |                                              3                           |             
      Muscularis, Mineralization           |                                           1                              |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                             1            |             
      Artery, Mineralization               |                   1                                                      |             
      Muscularis, Mineralization           |                   1                       2                              |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 2  1  1        1        1  1  1  1  1     1        1  1  1     1  1  1   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Angiectasis                          | 1  1                             1                                       |             
      Vacuolization Cytoplasmic            |       2                                                                  |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                         1                                      1         |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |       +                    +        +  +     +                       +   |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +     +  +  +  +  +  M  +  M     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                                                                          |             
      Pars Distalis, Cyst                  | 1           1     2           2  1                    1     2  3  1     1|             
      Pars Distalis, Hyperplasia           |                   2                                                      |             
      Pars Intermedia, Cyst                |    2              1                          1                          1|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  M  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                   4      |             
      Inflammation, Chronic                |                1                          1                    1         |             
      Inflammation, Chronic Active         | 1     1           1                 1  1     1     1        1            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  64                                                               
NTP Experiment-Test: 05061-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 11:03:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 2| 2| 4| 4| 0| 4| 3| 4| 4| 2| 2| 2| 4| 3| 2| 2| 2| 4| 4| 4| 4| 2|             
                             DAY ON TEST   | 6| 6| 2| 8| 7| 6| 6| 6| 6| 0| 6| 6| 9| 9| 7| 4| 1| 7| 7| 7| 6| 6| 6| 2| 7|             
                                           | 4| 2| 6| 1| 9| 4| 2| 5| 2| 6| 4| 4| 9| 4| 9| 1| 3| 9| 9| 9| 4| 4| 2| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    2.0%                                   | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    71HF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Periovarian Tissue, Cyst             |                   3              2        3                 4            |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Hydrometra                           |                2              2     1  2  1                       1      |             
      Inflammation, Chronic Active         |                                              2                           |             
      Endometrium, Hyperplasia             |                                              2                           |             
      Submucosa, Hyperplasia               |                         1                                                |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |       +  M  M                    +  +     +        +  M  M              +|             
      Mediastinal, Pigmentation            |                                           2        1                     |             
      Pancreatic, Infiltration Cellular,   |                                                                          |             
           Histiocyte                      |       3                          3  2     3        3                    3|             
      Pancreatic, Pigmentation             |                                  2        2        2                    2|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  M     +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                               1                          1              1|             
      Hyperplasia                          |                                                                          |             
      Infiltration Cellular, Histiocyte    |       1                    1           1  1                    1     1   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Depletion Lymphoid                   |                                                                      3   |             
      Hemorrhage                           |             1                                            3              1|             
      Infiltration Cellular, Histiocyte    | 2  1  1  3  2  2  1     2  1  2  2  1  2  1  2     1  1  1  2  2  2  1  1|             
      Pigmentation                         | 2  1     2     1  1     1     2  2                          2  1  1      |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                         2|             
      Fibrosis                             |                                                                      1   |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  M  +  M     +  +  +  +  +  +  +  M     +  +  +  +  +  I  M  +|             
      Depletion Lymphoid                   |    2           3                 1                          1  2         |             
      Hemorrhage                           |                                                          1               |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  M  M  +  +     M  +  M  +  +  +  +  +     +  M  +  +  +  M  +  +|             
      Hyperplasia                          |    1  2           1                          2                       2   |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  65                                                               
NTP Experiment-Test: 05061-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 11:03:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 2| 2| 4| 4| 0| 4| 3| 4| 4| 2| 2| 2| 4| 3| 2| 2| 2| 4| 4| 4| 4| 2|             
                             DAY ON TEST   | 6| 6| 2| 8| 7| 6| 6| 6| 6| 0| 6| 6| 9| 9| 7| 4| 1| 7| 7| 7| 6| 6| 6| 2| 7|             
                                           | 4| 2| 6| 1| 9| 4| 2| 5| 2| 6| 4| 4| 9| 4| 9| 1| 3| 9| 9| 9| 4| 4| 2| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    2.0%                                   | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    71HF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Infiltration Cellular, Histiocyte    | 1  1        1  1  1     1     1  1                 1     1  1  1  1  1  1|             
      Inflammation, Chronic Active         |       3                                                                  |             
      Artery, Mineralization               | 1                 1        1  1  1     1     1              1  1         |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |       3                                                                  |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |          M  M                       +     M        M  M  M              +|             
      Anterior Chamber, Inflammation, Acute|                                                                         2|             
      Posterior Chamber, Inflammation,     |                                                                          |             
           Acute                           |                                                                         2|             
      Retina, Degeneration                 |                                                                         4|             
                                            __________________________________________________________________________|             
   Harderian Gland                         |          M  M                             M        M  M  M              +|             
      Hyperplasia                          |                                                                         3|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Fibrosis, Focal                      |                                                                          |             
      Fibrosis                             |                                                                      3   |             
      Infiltration Cellular, Mononuclear   |                                                                          |             
          Cell                             |          1  1                                         1  1              1|             
      Inflammation, Chronic Active         |                                                                      3   |             
      Mineralization, Focal                |                                                                          |             
      Mineralization                       |                                                    1                     |             
      Nephropathy                          | 3  3  2        2  2     2  1  2  2  1  1     2              2  2  2  2   |             
      Papilla, Necrosis, Coagulative       |       3                                                              4   |             
      Pelvis, Inflammation, Chronic Active |                   2                                                      |             
      Renal Tubule, Hyperplasia            |       2                                                     1            |             
      Renal Tubule, Pigmentation           | 2  2  2  2  2  2  2     2  2  2  2  2  2  2  2     2  2  2  2  2  2  2  2|             
      Renal Tubule, Regeneration           |          1  1                             1              1              1|             
      Transitional Epithelium, Hyperplasia | 1                 3     1                                         1  2   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Hemorrhage                           |       1                    4           4                             2   |             
      Necrosis                             |                                                                      2   |             
      Fat, Proliferation                   |       3                                3                                 |             
      Transitional Epithelium, Hyperplasia | 2  2  3        3  4     3  4  1  3  4  2     2     2        2  3     3  1|             
      Transitional Epithelium, Metaplasia, |                                                                          |             
           Squamous                        |       2                                      4                       2   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  66                                                               
NTP Experiment-Test: 05061-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 11:03:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 2| 2| 2|                                                           |            |
                             DAY ON TEST   | 6| 6| 8| 7| 7|                                                           |            |
                                           | 2| 1| 1| 9| 9|                                                           |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0|                                                           |      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1|                                                           |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2|                                                           |      A     |
    2.0%                                   | 4| 4| 4| 4| 4|                                                           |      L     |
    71HF                                   | 1| 2| 3| 4| 5|                                                           |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +                                                            |  28        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +                                                            |  28        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +                                                            |  27        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +                                                            |  28        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +                                                            |  28        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +                                                            |  27        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +                                                            |  28        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +                                                            |  28        |
      Angiectasis                          |                                                                          |      2  1.5|
      Basophilic Focus                     | 1  2  2                                                                  |     16  1.5|
      Clear Cell Focus                     |    1        1                                                            |     14  1.1|
      Cytomegaly                           |                                                                          |      2  1.0|
      Eosinophilic Focus                   |    2                                                                     |      3  1.7|
      Fatty Change                         | 1  2  1  1  1                                                            |     17  1.2|
      Hematopoietic Cell Proliferation     |                                                                          |      1  1.0|
      Inflammation, Chronic, Granulomatous |                                                                          |      1  2.0|
      Inflammation, Chronic Active         |                                                                          |      1  1.0|
      Mixed Cell Focus                     |                                                                          |      3  1.7|
      Necrosis, Coagulative                |       1  1  1                                                            |     12  1.0|
      Pigmentation                         | 1     1  2  1                                                            |     27  1.2|
      Bile Duct, Hyperplasia               | 2  1  1  2                                                               |     27  1.4|
      Periportal, Inflammation, Chronic    | 2                                                                        |     11  2.1|
      Periportal, Inflammation, Chronic    |                                                                          |            |
          Active                           |    2  2  2  2                                                            |     17  1.5|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   1        |
      Inflammation, Chronic, Granulomatous |                                                                          |      1  4.0|
      Necrosis, Coagulative                |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +                                                            |  28        |
      Atrophy                              |       1                                                                  |      5  1.2|
      Ectopic Tissue                       |                                                                          |      1  1.0|
      Infiltration Cellular, Mononuclear   |                                                                          |            |
          Cell                             |       1  1                                                               |      4  1.3|
      Inflammation, Chronic                |                                                                          |      6  1.0|
      Inflammation, Chronic Active         |                                                                          |      2  1.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +                                                            |  28        |
      Duct, Submandibular Gland, Dilatation|                                                                          |      1  3.0|
      Parotid Gland, Atrophy               |                                                                          |      1  2.0|
      Parotid Gland, Inflammation, Chronic |                                                                          |      2  1.0|
      Parotid Gland, Inflammation, Chronic |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  67                                                               
NTP Experiment-Test: 05061-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 11:03:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 2| 2| 2|                                                           |            |
                             DAY ON TEST   | 6| 6| 8| 7| 7|                                                           |            |
                                           | 2| 1| 1| 9| 9|                                                           |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0|                                                           |      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1|                                                           |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2|                                                           |      A     |
    2.0%                                   | 4| 4| 4| 4| 4|                                                           |      L     |
    71HF                                   | 1| 2| 3| 4| 5|                                                           |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
          Active                           |                                                                          |      2  1.0|
      Submandibular Gland, Atrophy         |                                                                          |      1  2.0|
      Submandibular Gland, Inflammation,   |                                                                          |            |
           Chronic                         |                                                                          |      1  1.0|
      Submandibular Gland, Inflammation,   |                                                                          |            |
           Chronic Active                  |                                                                          |      5  2.2|
      Submandibular Gland, Metaplasia,     |                                                                          |            |
           Squamous                        |                                                                          |      2  1.5|
      Submandibular Gland, Pigmentation    |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +                                                            |  28        |
      Acanthosis                           |                                                                          |      1  1.0|
      Erosion                              |                                                                          |      1  2.0|
      Hyperkeratosis                       |                                                                          |      1  1.0|
      Hyperplasia, Basal Cell              | 1                                                                        |      6  1.0|
      Hyperplasia, Squamous                |                                                                          |      2  2.0|
      Ulcer                                |                                                                          |      1  3.0|
      Muscularis, Mineralization           |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +                                                            |  28        |
      Inflammation, Chronic                |                                                                          |      1  1.0|
      Artery, Mineralization               |                                                                          |      1  1.0|
      Muscularis, Mineralization           |                                                                          |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +                                                            |  28        |
      Cardiomyopathy                       |    1        1                                                            |     18  1.1|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  M  +  +  +                                                            |  27        |
      Angiectasis                          |                                                                          |      3  1.0|
      Vacuolization Cytoplasmic            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  M  +  +  +                                                            |  27        |
      Hyperplasia                          |                                                                          |      2  1.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |    +                                                                     |   7        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  M  +  +  +                                                            |  25        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +                                                            |  28        |
      Pars Distalis, Angiectasis           |       1                                                                  |      1  1.0|
      Pars Distalis, Cyst                  | 2                                                                        |     11  1.5|
      Pars Distalis, Hyperplasia           |    1                                                                     |      2  1.5|
      Pars Intermedia, Cyst                |                                                                          |      4  1.3|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  68                                                               
NTP Experiment-Test: 05061-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 11:03:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 2| 2| 2|                                                           |            |
                             DAY ON TEST   | 6| 6| 8| 7| 7|                                                           |            |
                                           | 2| 1| 1| 9| 9|                                                           |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0|                                                           |      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1|                                                           |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2|                                                           |      A     |
    2.0%                                   | 4| 4| 4| 4| 4|                                                           |      L     |
    71HF                                   | 1| 2| 3| 4| 5|                                                           |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +                                                            |  28        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +                                                            |  27        |
      Cyst                                 |                                                                          |      1  4.0|
      Inflammation, Chronic                | 1                                                                        |      4  1.0|
      Inflammation, Chronic Active         |    1     1                                                               |     10  1.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +                                                            |  28        |
      Periovarian Tissue, Cyst             |                                                                          |      4  3.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +                                                            |  28        |
      Hydrometra                           |                                                                          |      6  1.5|
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Endometrium, Hyperplasia             |                                                                          |      1  2.0|
      Submucosa, Hyperplasia               |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +                                                            |  28        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +     M  +  +                                                            |   9        |
      Mediastinal, Pigmentation            |             2                                                            |      3  1.7|
      Pancreatic, Infiltration Cellular,   |                                                                          |            |
           Histiocyte                      | 3        3                                                               |      8  2.9|
      Pancreatic, Pigmentation             | 1        2  2                                                            |      7  1.9|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +                                                            |  27        |
      Hemorrhage                           |                                                                          |      3  1.0|
      Hyperplasia                          |             2                                                            |      1  2.0|
      Infiltration Cellular, Histiocyte    |    1                                                                     |      7  1.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +                                                            |  28        |
      Depletion Lymphoid                   |                                                                          |      1  3.0|
      Hemorrhage                           |       2     2                                                            |      5  1.8|
      Infiltration Cellular, Histiocyte    | 2  1  1  1  1                                                            |     28  1.5|
      Pigmentation                         | 2                                                                        |     12  1.5|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +                                                            |  28        |
      Congestion                           |                                                                          |      1  2.0|
      Fibrosis                             |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  M  +  +  +                                                            |  22        |
      Depletion Lymphoid                   | 2                                                                        |      6  1.8|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  69                                                               
NTP Experiment-Test: 05061-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 11:03:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 2| 2| 2|                                                           |            |
                             DAY ON TEST   | 6| 6| 8| 7| 7|                                                           |            |
                                           | 2| 1| 1| 9| 9|                                                           |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0|                                                           |      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1|                                                           |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2|                                                           |      A     |
    2.0%                                   | 4| 4| 4| 4| 4|                                                           |      L     |
    71HF                                   | 1| 2| 3| 4| 5|                                                           |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Hemorrhage                           |          1                                                               |      2  1.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  +  +  M  M                                                            |  19        |
      Hyperplasia                          |                                                                          |      5  1.6|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +                                                            |  28        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +                                                            |  28        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +                                                            |  28        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +                                                            |  28        |
      Infiltration Cellular, Histiocyte    |    1        1                                                            |     17  1.0|
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
      Artery, Mineralization               | 1     1  1                                                               |     12  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +                                                            |  28        |
      Inflammation, Chronic Active         |    1                                                                     |      2  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +                                                            |  28        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |       M  M  M                                                            |   2        |
      Anterior Chamber, Inflammation, Acute|                                                                          |      1  2.0|
      Posterior Chamber, Inflammation,     |                                                                          |            |
           Acute                           |                                                                          |      1  2.0|
      Retina, Degeneration                 |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |       M  M  M                                                            |   1        |
      Hyperplasia                          |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +                                                            |  28        |
      Fibrosis, Focal                      |             2                                                            |      1  2.0|
      Fibrosis                             |                                                                          |      1  3.0|
      Infiltration Cellular, Mononuclear   |                                                                          |            |
          Cell                             |       1  1                                                               |      7  1.0|
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
      Mineralization, Focal                |             2                                                            |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  70                                                               
NTP Experiment-Test: 05061-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 11:03:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 2| 2| 2|                                                           |            |
                             DAY ON TEST   | 6| 6| 8| 7| 7|                                                           |            |
                                           | 2| 1| 1| 9| 9|                                                           |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0|                                                           |      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1|                                                           |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2|                                                           |      A     |
    2.0%                                   | 4| 4| 4| 4| 4|                                                           |      L     |
    71HF                                   | 1| 2| 3| 4| 5|                                                           |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Mineralization                       |                                                                          |      1  1.0|
      Nephropathy                          | 4  2                                                                     |     18  2.1|
      Papilla, Necrosis, Coagulative       |                                                                          |      2  3.5|
      Pelvis, Inflammation, Chronic Active |                                                                          |      1  2.0|
      Renal Tubule, Hyperplasia            |                                                                          |      2  1.5|
      Renal Tubule, Pigmentation           | 2  2  2  2  2                                                            |     28  2.0|
      Renal Tubule, Regeneration           |       1  1                                                               |      7  1.0|
      Transitional Epithelium, Hyperplasia |                                                                          |      5  1.6|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +                                                            |  28        |
      Hemorrhage                           |                                                                          |      4  2.8|
      Necrosis                             |                                                                          |      1  2.0|
      Fat, Proliferation                   |                                                                          |      2  3.0|
      Transitional Epithelium, Hyperplasia | 2  2  1  2                                                               |     21  2.4|
      Transitional Epithelium, Metaplasia, |                                                                          |            |
           Squamous                        |                                                                          |      3  2.7|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  71                                                               
NTP Experiment-Test: 05061-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 11:03:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 5|                                            |            |
                                           | 4| 4| 4| 4| 2| 4| 4| 2| 2| 6|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    2.0%                                   | 1| 1| 1| 1| 1| 5| 5| 5| 5| 5|                                            |      L     |
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Parasite Metazoan                    |                      2                                                   |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Parasite Metazoan                    |                         1                                                |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Parasite Metazoan                    |       1        1                                                         |      2  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Basophilic Focus                     | 1  2     1  1  1  1                                                      |      6  1.2|
      Clear Cell Focus                     | 1  1        1     1     1                                                |      5  1.0|
      Cyst                                 |          3                                                               |      1  3.0|
      Cytomegaly                           |                         1                                                |      1  1.0|
      Cytoplasmic Alteration               |          1                                                               |      1  1.0|
      Eosinophilic Focus                   |       1                    1                                             |      2  1.0|
      Inflammation, Chronic, Granulomatous |                1  1                                                      |      2  1.0|
      Mixed Cell Focus                     |                   1        2                                             |      2  1.5|
      Pigmentation                         | 1  1  1  1  1  1  1  1  1  1                                             |     10  1.0|
      Bile Duct, Hyperplasia               | 2  2  2  1  1  1  1  2  2  1                                             |     10  1.5|
      Periportal, Inflammation, Chronic    | 2  2  2  1  1  1  2  2  2                                                |      9  1.7|
      Periportal, Inflammation, Chronic    |                                                                          |            |
          Active                           |                            1                                             |      1  1.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Atrophy                              |             1        2  1                                                |      3  1.3|
      Inflammation, Chronic                |       1  1  1     1  1  1                                                |      6  1.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Mineralization                       |                1                                                         |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                +                                                         |   1        |
      Aorta, Inflammation, Chronic         |                4                                                         |      1  4.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Cardiomyopathy                       | 1  1  1  1  1  1  1  1  2  1                                             |     10  1.1|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  72                                                               
NTP Experiment-Test: 05061-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 11:03:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 5|                                            |            |
                                           | 4| 4| 4| 4| 2| 4| 4| 2| 2| 6|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    2.0%                                   | 1| 1| 1| 1| 1| 5| 5| 5| 5| 5|                                            |      L     |
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Angiectasis                          |                1     2                                                   |      2  1.5|
      Hyperplasia                          |    2                                                                     |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Hyperplasia                          |                            1                                             |      1  1.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |                            +                                             |   1        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Hyperplasia                          |                            2                                             |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Pars Distalis, Angiectasis           |          2     2  2  2  2                                                |      5  2.0|
      Pars Distalis, Cyst                  | 3  2  2  1     3  2                                                      |      6  2.2|
      Pars Intermedia, Cyst                |       2                                                                  |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Inflammation, Chronic                | 1  1  1  1  1        2                                                   |      6  1.2|
      Inflammation, Chronic Active         |                            1                                             |      1  1.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Hydrometra                           |             2     2                                                      |      2  2.0|
      Endometrium, Hyperplasia             |    2                                                                     |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +                                                                        |   1        |
      Mediastinal, Hemorrhage              | 4                                                                        |      1  4.0|
      Pancreatic, Infiltration Cellular,   |                                                                          |            |
           Histiocyte                      | 2                                                                        |      1  2.0|
      Pancreatic, Pigmentation             | 2                                                                        |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  M  +  +  +  +  +                                             |   9        |
      Hemorrhage                           | 1              2     3                                                   |      3  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | M  +  +  +  +  +  +  +  +  +                                             |   9        |
      Hemorrhage                           |          2           1                                                   |      2  1.5|
      Infiltration Cellular, Histiocyte    |    2  2  1  1  2  1  1  1  2                                             |      9  1.4|
      Pigmentation                         |    1  1  1  1  1  1  1  1                                                |      8  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  73                                                               
NTP Experiment-Test: 05061-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 11:03:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 5|                                            |            |
                                           | 4| 4| 4| 4| 2| 4| 4| 2| 2| 6|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    2.0%                                   | 1| 1| 1| 1| 1| 5| 5| 5| 5| 5|                                            |      L     |
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Depletion Lymphoid                   |                1                                                         |      1  1.0|
      Hemorrhage                           |                2                                                         |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  M  +  +  +  M  +  M  +                                             |   7        |
      Hyperplasia                          |          1  1        2     2                                             |      4  1.5|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Congestion                           |                            1                                             |      1  1.0|
      Infiltration Cellular, Histiocyte    |    1     1  1  1  1  1  1                                                |      7  1.0|
      Artery, Mineralization               | 1     1        1  1     1                                                |      5  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Nephropathy                          | 2  2  2  2  2  2  2  2  2  4                                             |     10  2.2|
      Renal Tubule, Hyperplasia            |       1                    3                                             |      2  2.0|
      Renal Tubule, Inflammation, Chronic  |                                                                          |            |
          Active                           |                            2                                             |      1  2.0|
      Renal Tubule, Pigmentation           | 1  2  2  2  2  2  2  2  2  2                                             |     10  1.9|
      Transitional Epithelium, Hyperplasia |                1                                                         |      1  1.0|
      Transitional Epithelium,             |                                                                          |            |
          Mineralization                   |                1                                                         |      1  1.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Transitional Epithelium, Hyperplasia | 1                 3  2  1                                                |      4  1.8|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  74                                                               
NTP Experiment-Test: 05061-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 11:03:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 4| 6| 5| 7| 7| 7| 2| 2| 6| 6| 5| 2| 2| 4| 7| 2| 2| 2| 7| 7| 7| 6| 2|             
                             DAY ON TEST   | 3| 9| 5| 7| 8| 3| 3| 0| 7| 7| 6| 4| 5| 7| 7| 5| 3| 7| 7| 7| 3| 3| 2| 5| 7|             
                                           | 5| 2| 6| 4| 7| 4| 4| 7| 5| 5| 6| 6| 6| 6| 6| 8| 4| 3| 6| 5| 4| 4| 7| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    UNTREATE                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    D 71 UM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Autolysis                            |                                                                          |             
      Parasite Metazoan                    |                      1  1  2     1           1                 1         |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Parasite Metazoan                    |                                                                1         |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Parasite Metazoan                    | 1                                            1                 1         |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                1         |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |    1                                                                     |             
      Autolysis                            |                                                                          |             
      Basophilic Focus                     | 1                                            1                           |             
      Clear Cell Focus                     | 1                                                                        |             
      Degeneration                         |    1  1              2                                                   |             
      Eosinophilic Focus                   |                                                                          |             
      Fatty Change                         |                         1           3     1        1                     |             
      Fibrosis                             |                                                                          |             
      Hematopoietic Cell Proliferation     |       1                                                                  |             
      Hepatodiaphragmatic Nodule           |                                                                          |             
      Inflammation, Chronic, Granulomatous |                                                                          |             
      Inflammation, Chronic Active         | 1              1                                         1               |             
      Mixed Cell Focus                     |                                                             1            |             
      Necrosis, Coagulative                |                                                       1                  |             
      Pigmentation                         |             1                                   1                        |             
      Regeneration                         |                                                                          |             
      Bile Duct, Hyperplasia               | 1  1  1  1  2  1  1  1        1  3           1  1     1     1  1  1  3   |             
      Periportal, Inflammation, Chronic    |       1                                      1                           |             
      Periportal, Inflammation, Chronic    |                                                                          |             
          Active                           |                         1  1           1           1  1  1              1|             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |    2                          2  2                                   1  2|             
      Ectopic Tissue                       |          X                                                               |             
      Infiltration Cellular, Mononuclear   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  75                                                               
NTP Experiment-Test: 05061-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 11:03:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 4| 6| 5| 7| 7| 7| 2| 2| 6| 6| 5| 2| 2| 4| 7| 2| 2| 2| 7| 7| 7| 6| 2|             
                             DAY ON TEST   | 3| 9| 5| 7| 8| 3| 3| 0| 7| 7| 6| 4| 5| 7| 7| 5| 3| 7| 7| 7| 3| 3| 2| 5| 7|             
                                           | 5| 2| 6| 4| 7| 4| 4| 7| 5| 5| 6| 6| 6| 6| 6| 8| 4| 3| 6| 5| 4| 4| 7| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    UNTREATE                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    D 71 UM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
          Cell                             |                         1                                               2|             
      Inflammation, Chronic                |       1                                                  1               |             
      Inflammation, Chronic Active         |    1              1                                2                     |             
      Necrosis, Coagulative                |                                                    1     1               |             
      Pigmentation                         |                                                                          |             
      Vacuolization Cytoplasmic            |             2                 1  2              1                 1  1   |             
      Acinus, Atrophy                      |                         2                                                |             
      Artery, Polyarteritis                |                3                                                         |             
      Duct, Hyperplasia                    |                      4                                                   |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Hyperkeratosis                       |                      3              3                                    |             
      Hyperplasia, Basal Cell              |                      2              2                                    |             
      Hyperplasia, Squamous                |                      2                                                   |             
      Inflammation, Chronic Active         |                                                                          |             
      Ulcer                                |                                     4                                    |             
      Muscularis, Mineralization           |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Mucosa, Necrosis, Coagulative        |          1                                                               |             
      Muscularis, Mineralization           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 2  2  1  1  1  1  1  1  1  2  1  2  1  1  2  2  1  1  1  1  1  2  2  1  1|             
      Thrombosis                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia                          |                                                                   2      |             
      Necrosis, Coagulative                |          2                                                               |             
      Vacuolization Cytoplasmic            |          3        1  2        1     2           2           1            |             
      Bilateral, Vacuolization Cytoplasmic |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia                          | 1                    1        1  2              2  1                     |             
      Necrosis, Coagulative                |                                                                      2   |             
      Bilateral, Hyperplasia               |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +        +  +  +        +  +           +  +  +  +   |             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  76                                                               
NTP Experiment-Test: 05061-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 11:03:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 4| 6| 5| 7| 7| 7| 2| 2| 6| 6| 5| 2| 2| 4| 7| 2| 2| 2| 7| 7| 7| 6| 2|             
                             DAY ON TEST   | 3| 9| 5| 7| 8| 3| 3| 0| 7| 7| 6| 4| 5| 7| 7| 5| 3| 7| 7| 7| 3| 3| 2| 5| 7|             
                                           | 5| 2| 6| 4| 7| 4| 4| 7| 5| 5| 6| 6| 6| 6| 6| 8| 4| 3| 6| 5| 4| 4| 7| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    UNTREATE                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    D 71 UM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    3                                            3                        |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |                            1                                   1         |             
      Pars Distalis, Hyperplasia           |       2        1           1  2                 2     1     2            |             
      Pars Intermedia, Cyst                |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      C-Cell, Hyperplasia                  |          1     1              1                                1     1   |             
      Follicle, Cyst                       |                                                                          |             
      Follicular Cell, Hyperplasia         |                                                             2            |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Aspermia                             |                                                                          |             
      Inflammation, Chronic Active         |                               1                                          |             
      Vacuolization Cytoplasmic            |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Abscess                              |    4        2                                                        2   |             
      Cyst                                 |                                                                          |             
      Inflammation, Chronic                |       2                                      1     1  1                  |             
      Inflammation, Chronic Active         | 2        2     2  2  2  1  1  3  2  1  1  1     1        1  1  2  2  2   |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                                                    1                     |             
      Inflammation, Chronic Active         |                      2              4           2                        |             
      Metaplasia, Squamous                 |                                                                          |             
      Epithelium, Hyperplasia              |                1  1           1                 1                        |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Polyarteritis                        |                                                                          |             
      Interstitial Cell, Hyperplasia       |       1     1        2           2  1        1                           |             
      Seminiferous Tubule, Atrophy         | 4  4     4     4  4  3        3  4  1           4           4  4  4  3   |             
      Seminiferous Tubule, Mineralization  |                                                 1                        |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Sternal, Myelofibrosis               |                      2                                                   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  77                                                               
NTP Experiment-Test: 05061-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 11:03:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 4| 6| 5| 7| 7| 7| 2| 2| 6| 6| 5| 2| 2| 4| 7| 2| 2| 2| 7| 7| 7| 6| 2|             
                             DAY ON TEST   | 3| 9| 5| 7| 8| 3| 3| 0| 7| 7| 6| 4| 5| 7| 7| 5| 3| 7| 7| 7| 3| 3| 2| 5| 7|             
                                           | 5| 2| 6| 4| 7| 4| 4| 7| 5| 5| 6| 6| 6| 6| 6| 8| 4| 3| 6| 5| 4| 4| 7| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    UNTREATE                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    D 71 UM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +  M  +  +           M  M  +        M  M  M  +  M  +  M           +  M|             
      Mediastinal, Hemorrhage              |                                                                          |             
      Mediastinal, Pigmentation            |                                                       1                  |             
      Mediastinal, Sinus, Ectasia          |                                                                          |             
      Renal, Hemorrhage                    |                                                                          |             
      Renal, Infiltration Cellular,        |                                                                          |             
          Histiocyte                       |                                                 4                        |             
      Renal, Pigmentation                  |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                         1  3           3  1        1  2  3               |             
      Hyperplasia                          | 3                                                           2  3         |             
      Infiltration Cellular, Histiocyte    |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Depletion Lymphoid                   |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Infiltration Cellular, Histiocyte    | 1  1  1  1  2  1  1  1  1  1     1     1  1  1  2  1  1  1  1  1  1  1  1|             
      Pigmentation                         |       1                                      1                           |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Depletion Lymphoid                   |          4                          1                                3   |             
      Fibrosis                             | 2                             1                                          |             
      Necrosis, Coagulative                |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  M  +  +  +  +  M  +  +  +  +  M  M  M  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                1                                                         |             
      Depletion Lymphoid                   |                         2                          2  3                  |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  +  +  M  M  +  +  M  +  +  +  +  +  +  +  M  M  +  +  +  M  +  M  M  M|             
      Galactocele                          |                2                    2                                    |             
      Hyperplasia                          |       1           2     1  1  2  4  3  1  2           1  1               |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                                                          |             
      Fibrosis                             |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infarct                              |          1                    1                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |          +  +                                                     +      |             
      Infarct                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  78                                                               
NTP Experiment-Test: 05061-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 11:03:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 4| 6| 5| 7| 7| 7| 2| 2| 6| 6| 5| 2| 2| 4| 7| 2| 2| 2| 7| 7| 7| 6| 2|             
                             DAY ON TEST   | 3| 9| 5| 7| 8| 3| 3| 0| 7| 7| 6| 4| 5| 7| 7| 5| 3| 7| 7| 7| 3| 3| 2| 5| 7|             
                                           | 5| 2| 6| 4| 7| 4| 4| 7| 5| 5| 6| 6| 6| 6| 6| 8| 4| 3| 6| 5| 4| 4| 7| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    UNTREATE                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    D 71 UM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Crystals                             |                                                                          |             
      Infiltration Cellular, Histiocyte    |    1              1        1     1  1           1           1  1  1  1   |             
      Necrosis, Coagulative                |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                                 2                        |             
      Alveolus, Mineralization             |                                                                          |             
      Artery, Mineralization               | 1     1        1  1  1  1           1     1     1  1     1        1      |             
      Artery, Thrombosis                   |          2                                                               |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Inflammation, Chronic Active         | 3        4  3     2  2        1     4                       1  1     2   |             
      Metaplasia, Squamous                 |          3        2                 3                                2   |             
      Ulcer                                |                   2  2                                                   |             
      Glands, Hyperplasia                  |             1                 2                                      1   |             
      Glands, Inflammation, Acute          |                                                                          |             
      Glands, Inflammation, Chronic Active |                                              1                           |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Chronic Active                  |                                                                          |             
      Respiratory Epithelium, Hyperplasia  |             2                                                            |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                         M  M  +        M  M        M  M  M              M|             
      Acanthosis                           |                                                                          |             
      Hyperkeratosis                       |                                                                          |             
      Hyperplasia, Basal Cell              |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |             +                                                            |             
      Anterior, Synechia                   |                                                                          |             
      Cornea, Inflammation, Chronic Active |                                                                          |             
      Retina, Degeneration                 |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Cyst                                 |          1                                                        1      |             
      Cyst, Multiple                       |                      3                                                   |             
      Granuloma                            |                                           2                              |             
      Hydronephrosis                       |                                                                          |             
      Inflammation, Chronic                |                                        1           1  1                 1|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  79                                                               
NTP Experiment-Test: 05061-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 11:03:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 4| 6| 5| 7| 7| 7| 2| 2| 6| 6| 5| 2| 2| 4| 7| 2| 2| 2| 7| 7| 7| 6| 2|             
                             DAY ON TEST   | 3| 9| 5| 7| 8| 3| 3| 0| 7| 7| 6| 4| 5| 7| 7| 5| 3| 7| 7| 7| 3| 3| 2| 5| 7|             
                                           | 5| 2| 6| 4| 7| 4| 4| 7| 5| 5| 6| 6| 6| 6| 6| 8| 4| 3| 6| 5| 4| 4| 7| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    UNTREATE                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    D 71 UM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Nephropathy                          | 4  4  2  3  2  3  3  4        3  3  3        2  4           3  3  3  2   |             
      Renal Tubule, Hyperplasia            | 2  2                 2                                                   |             
      Renal Tubule, Inflammation, Chronic  |                                                                          |             
          Active                           | 1  1                                            1           1            |             
      Renal Tubule, Mineralization         |                                                                          |             
      Renal Tubule, Pigmentation           |                                  3                                       |             
      Renal Tubule, Regeneration           |                         1  1           1  1        1  1  1              1|             
      Transitional Epithelium, Hyperplasia | 2  1     1     1  1  1        2     1           2           1  2  1  1   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calculus Micro Observation Only      |                         3              2                                 |             
      Hemorrhage                           |          2                                                               |             
      Hyperplasia, Lymphoid                | 2                                                                        |             
      Inflammation, Chronic Active         |                                                                          |             
      Serosa, Mineralization               |                                                                          |             
      Transitional Epithelium, Hyperplasia |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  80                                                               
NTP Experiment-Test: 05061-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 11:03:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 7| 6| 4| 7| 7| 7| 4| 7| 7| 6| 6| 5| 7| 4| 6| 4| 2| 7| 4| 7| 7| 6|             
                             DAY ON TEST   | 3| 5| 3| 3| 7| 5| 3| 3| 2| 3| 3| 3| 7| 3| 1| 3| 5| 9| 5| 7| 3| 5| 3| 3| 7|             
                                           | 4| 6| 4| 5| 1| 6| 4| 5| 1| 5| 4| 5| 9| 1| 4| 4| 8| 6| 6| 6| 4| 6| 4| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    UNTREATE                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    D 71 UM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                            3                                             |             
      Parasite Metazoan                    |    1  1        1                 1  1        1                          1|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  M  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                            3                                             |             
      Parasite Metazoan                    |       1           1        1                                   1  1      |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                            3                                             |             
      Parasite Metazoan                    |    1              1              1              1                        |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                            3                                             |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                            3                                             |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                            3                                             |             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |       2              1                                                   |             
      Autolysis                            |                                        3                                 |             
      Basophilic Focus                     |       1  1           1        1  2                                       |             
      Clear Cell Focus                     |                                              1                           |             
      Degeneration                         |    1  1     2        1           1           1                       1   |             
      Eosinophilic Focus                   |                                              1                           |             
      Fatty Change                         | 1  1  1     3  1              1                 1     1     2  1         |             
      Fibrosis                             |                                                                          |             
      Hematopoietic Cell Proliferation     |    1                                                                     |             
      Hepatodiaphragmatic Nodule           |                               2                    X                     |             
      Inflammation, Chronic, Granulomatous |                                                 1              1         |             
      Inflammation, Chronic Active         |                1                                1              1         |             
      Mixed Cell Focus                     |                                                                          |             
      Necrosis, Coagulative                |                1     1        1                 1              1         |             
      Pigmentation                         |                                           1                              |             
      Regeneration                         |             2                          3                    3            |             
      Bile Duct, Hyperplasia               | 1  1  1  1  2  2  2  2  1  1  1  1  2     2  1  1  1  1     2  1  2  1  1|             
      Periportal, Inflammation, Chronic    |    1           1                                1     1        1         |             
      Periportal, Inflammation, Chronic    |                                                                          |             
          Active                           |                                                          1               |             
                                            __________________________________________________________________________|             
   Mesentery                               |             +                       +                                    |             
      Inflammation, Chronic Active         |                                     1                                    |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |       1        1                                1              1         |             
      Ectopic Tissue                       |                                                                          |             
      Infiltration Cellular, Mononuclear   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  81                                                               
NTP Experiment-Test: 05061-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 11:03:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 7| 6| 4| 7| 7| 7| 4| 7| 7| 6| 6| 5| 7| 4| 6| 4| 2| 7| 4| 7| 7| 6|             
                             DAY ON TEST   | 3| 5| 3| 3| 7| 5| 3| 3| 2| 3| 3| 3| 7| 3| 1| 3| 5| 9| 5| 7| 3| 5| 3| 3| 7|             
                                           | 4| 6| 4| 5| 1| 6| 4| 5| 1| 5| 4| 5| 9| 1| 4| 4| 8| 6| 6| 6| 4| 6| 4| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    UNTREATE                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    D 71 UM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
          Cell                             |                                                                          |             
      Inflammation, Chronic                |    1           1                                1     1        1         |             
      Inflammation, Chronic Active         |       1  1                    1                                          |             
      Necrosis, Coagulative                |                                                                          |             
      Pigmentation                         |                                                                          |             
      Vacuolization Cytoplasmic            |                         1  1     1  2                                   1|             
      Acinus, Atrophy                      |                                                                          |             
      Artery, Polyarteritis                |                                                                   2  4   |             
      Duct, Hyperplasia                    |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       | 3                       2                                               1|             
      Hyperplasia, Basal Cell              | 3     1              1  2                                         1      |             
      Hyperplasia, Squamous                |                         2                                               1|             
      Inflammation, Chronic Active         | 2                       3                                               1|             
      Ulcer                                | 2                       2                                                |             
      Muscularis, Mineralization           |                                                                1         |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         | 1                                                                        |             
      Mucosa, Necrosis, Coagulative        |                                                                          |             
      Muscularis, Mineralization           |                                                                1         |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 2  1  2  2  2  1  2  1  1  3  2  2  1  2     1  1  3  1     2  1  2  2  1|             
      Thrombosis                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                     1                                    |             
      Hematopoietic Cell Proliferation     |                      1                                            1      |             
      Hyperplasia                          | 2              2     2                                                   |             
      Necrosis, Coagulative                |                                                                          |             
      Vacuolization Cytoplasmic            |       1     2     1        2     1        3  1     2                    1|             
      Bilateral, Vacuolization Cytoplasmic |                1                                                         |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Fibrosis                             |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                   1      |             
      Hyperplasia                          | 2     2     3     1                                         1     1      |             
      Necrosis, Coagulative                |                                                                          |             
      Bilateral, Hyperplasia               |                2                                                         |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +        +     +  +  +|             
      Hemorrhage                           |                                                 1                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  82                                                               
NTP Experiment-Test: 05061-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 11:03:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 7| 6| 4| 7| 7| 7| 4| 7| 7| 6| 6| 5| 7| 4| 6| 4| 2| 7| 4| 7| 7| 6|             
                             DAY ON TEST   | 3| 5| 3| 3| 7| 5| 3| 3| 2| 3| 3| 3| 7| 3| 1| 3| 5| 9| 5| 7| 3| 5| 3| 3| 7|             
                                           | 4| 6| 4| 5| 1| 6| 4| 5| 1| 5| 4| 5| 9| 1| 4| 4| 8| 6| 6| 6| 4| 6| 4| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    UNTREATE                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    D 71 UM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  M  +  +  M  +  +  M  +  +  +  +  +  M  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  M  +  I  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |                      1              1     2  1                           |             
      Pars Distalis, Hyperplasia           |    1           1  1     1                 2           1  1     1         |             
      Pars Intermedia, Cyst                |                      1                       1                           |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Inflammation, Chronic Active         |                                              1                           |             
      C-Cell, Hyperplasia                  | 1                    1                       1  1                        |             
      Follicle, Cyst                       |                                                                          |             
      Follicular Cell, Hyperplasia         |             1     1                                                      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       |                                                                         +|             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Aspermia                             |                                                                          |             
      Inflammation, Chronic Active         |                                  1                                       |             
      Vacuolization Cytoplasmic            |                                           3                              |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Abscess                              |       1                 3                                   2            |             
      Cyst                                 |                      3                                                   |             
      Inflammation, Chronic                |                2                                1                        |             
      Inflammation, Chronic Active         | 2  2  2  2  2     2  3  2  3  1  2  2  1  2  2        2  1  2  2     2  2|             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                                                                1         |             
      Inflammation, Chronic Active         |    3  4        1     4     3              3     2     2                  |             
      Metaplasia, Squamous                 |                      2                                                   |             
      Epithelium, Hyperplasia              |                   1                                1              2      |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Polyarteritis                        | 2                                                                        |             
      Interstitial Cell, Hyperplasia       |    2     1     2                    1  1  2     1     1  1     1        1|             
      Seminiferous Tubule, Atrophy         | 3     4  4  2     4  4  4     4  4     2  3  4     4  1     4     4  4  1|             
      Seminiferous Tubule, Mineralization  |             1        1           1     1                    1            |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Sternal, Myelofibrosis               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  83                                                               
NTP Experiment-Test: 05061-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 11:03:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 7| 6| 4| 7| 7| 7| 4| 7| 7| 6| 6| 5| 7| 4| 6| 4| 2| 7| 4| 7| 7| 6|             
                             DAY ON TEST   | 3| 5| 3| 3| 7| 5| 3| 3| 2| 3| 3| 3| 7| 3| 1| 3| 5| 9| 5| 7| 3| 5| 3| 3| 7|             
                                           | 4| 6| 4| 5| 1| 6| 4| 5| 1| 5| 4| 5| 9| 1| 4| 4| 8| 6| 6| 6| 4| 6| 4| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    UNTREATE                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    D 71 UM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    M        +           +           +  +                 +  +            |             
      Mediastinal, Hemorrhage              |                                        3                 1               |             
      Mediastinal, Pigmentation            |                                                                          |             
      Mediastinal, Sinus, Ectasia          |                                                                          |             
      Renal, Hemorrhage                    |                                                          2               |             
      Renal, Infiltration Cellular,        |                                                                          |             
          Histiocyte                       |                                                                          |             
      Renal, Pigmentation                  |                                                          1               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                 1        3               |             
      Hyperplasia                          | 3     3           2                          3                    2      |             
      Infiltration Cellular, Histiocyte    |                                                                      1  1|             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Depletion Lymphoid                   |                                                                3         |             
      Hemorrhage                           |                                                                          |             
      Infiltration Cellular, Histiocyte    | 1  1  1  1  1  2  1  1  1  1  1  1     1     1  2  1  2  1  1  1  1  1  1|             
      Pigmentation                         |    1           1                       1        1     1        1         |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Depletion Lymphoid                   |             3              2        4              3        4     2      |             
      Fibrosis                             |                                        3                    2            |             
      Necrosis, Coagulative                |                      4                                      2            |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  M  +  M  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Cyst                                 |    2                                1                                    |             
      Depletion Lymphoid                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  M  +  +  +  M  M  +  +  +  +  M  M  +  +  M  M  M  M  +  M|             
      Galactocele                          | 2                                                                        |             
      Hyperplasia                          |       4  2  3     1  1  2              2  2        2  2                  |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                                    3                     |             
      Fibrosis                             |                      2                                                   |             
      Inflammation, Chronic Active         |                      4                                                   |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                      +   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infarct                              |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                         +                                                |             
      Infarct                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  84                                                               
NTP Experiment-Test: 05061-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 11:03:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 7| 6| 4| 7| 7| 7| 4| 7| 7| 6| 6| 5| 7| 4| 6| 4| 2| 7| 4| 7| 7| 6|             
                             DAY ON TEST   | 3| 5| 3| 3| 7| 5| 3| 3| 2| 3| 3| 3| 7| 3| 1| 3| 5| 9| 5| 7| 3| 5| 3| 3| 7|             
                                           | 4| 6| 4| 5| 1| 6| 4| 5| 1| 5| 4| 5| 9| 1| 4| 4| 8| 6| 6| 6| 4| 6| 4| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    UNTREATE                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    D 71 UM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Crystals                             |                                     1                                    |             
      Infiltration Cellular, Histiocyte    | 1        1           1                    1  1        1           1     1|             
      Necrosis, Coagulative                |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                2  1                             1              2        1|             
      Alveolus, Mineralization             |                                                 1                        |             
      Artery, Mineralization               | 1  1     1     1           1  1  1        1  1  1     1  1     1  1      |             
      Artery, Thrombosis                   |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                        3                                 |             
      Inflammation, Chronic Active         | 1     1  2        3        3  3  1  2     3                 3           2|             
      Metaplasia, Squamous                 |          1        2           2                                         1|             
      Ulcer                                |                                                                          |             
      Glands, Hyperplasia                  |       1  2        1           1     2                       1            |             
      Glands, Inflammation, Acute          |                1                                               1         |             
      Glands, Inflammation, Chronic Active |                                                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Chronic Active                  |                2                                                         |             
      Respiratory Epithelium, Hyperplasia  |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                     +              +     M               |             
      Acanthosis                           |                                     2                                    |             
      Hyperkeratosis                       |                                     2                                    |             
      Hyperplasia, Basal Cell              |                                     2                                    |             
      Inflammation, Chronic Active         |                                     1                                    |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     | I                       +                 +                              |             
      Anterior, Synechia                   |                                                                          |             
      Cornea, Inflammation, Chronic Active |                                                                          |             
      Retina, Degeneration                 |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                              +                           |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                            3           3                                 |             
      Cyst                                 |          1                                                               |             
      Cyst, Multiple                       |                                                                          |             
      Granuloma                            |                                                                          |             
      Hydronephrosis                       |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  85                                                               
NTP Experiment-Test: 05061-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 11:03:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 7| 6| 4| 7| 7| 7| 4| 7| 7| 6| 6| 5| 7| 4| 6| 4| 2| 7| 4| 7| 7| 6|             
                             DAY ON TEST   | 3| 5| 3| 3| 7| 5| 3| 3| 2| 3| 3| 3| 7| 3| 1| 3| 5| 9| 5| 7| 3| 5| 3| 3| 7|             
                                           | 4| 6| 4| 5| 1| 6| 4| 5| 1| 5| 4| 5| 9| 1| 4| 4| 8| 6| 6| 6| 4| 6| 4| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    UNTREATE                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    D 71 UM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Nephropathy                          | 3  2  4  3  3  2  3  2  2  2  3  4  2  2  2  4  2  3  2     2  2  3  3  2|             
      Renal Tubule, Hyperplasia            |       4                                                                  |             
      Renal Tubule, Inflammation, Chronic  |                                                                          |             
          Active                           |                               1              1              1     1      |             
      Renal Tubule, Mineralization         |                                                                          |             
      Renal Tubule, Pigmentation           |             2                       2  1                    2            |             
      Renal Tubule, Regeneration           |                                                          1               |             
      Transitional Epithelium, Hyperplasia | 1     2  2           2        1  1           1                    1  1   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calculus Micro Observation Only      |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                | 1     1                 1                                                |             
      Inflammation, Chronic Active         |                                                                          |             
      Serosa, Mineralization               |                                                          1               |             
      Transitional Epithelium, Hyperplasia |                      2                                                   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  86                                                               
NTP Experiment-Test: 05061-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 11:03:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 5| 4| 7| 4| 7| 5| 4| 7| 7| 4| 5| 2| 7| 7| 7| 7| 5|              |            |
                             DAY ON TEST   | 5| 3| 2| 4| 2| 3| 2| 3| 7| 5| 3| 3| 5| 7| 7| 3| 3| 3| 3| 6|              |            |
                                           | 8| 4| 1| 9| 1| 4| 7| 4| 4| 6| 1| 1| 6| 3| 5| 4| 1| 3| 5| 2|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |      A     |
    UNTREATE                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |      L     |
    D 71 UM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  69        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  67        |
      Autolysis                            |                                                                          |      1  3.0|
      Parasite Metazoan                    |                1     1        2     1        1        1                  |     19  1.1|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | M  +  M  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  65        |
      Autolysis                            |                                                                          |      1  3.0|
      Parasite Metazoan                    |                      1                                                   |      7  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  68        |
      Autolysis                            |                                                    2                     |      2  2.5|
      Parasite Metazoan                    |                                                                          |      7  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  68        |
      Autolysis                            |                                                    3                     |      2  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  68        |
      Autolysis                            |                                                    4                     |      2  3.5|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  68        |
      Autolysis                            |                                        3           2                     |      3  2.7|
      Hyperplasia, Lymphoid                |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Angiectasis                          |                                                                          |      3  1.3|
      Autolysis                            |                                                    1                     |      2  2.0|
      Basophilic Focus                     |                1     1        1                                          |     10  1.1|
      Clear Cell Focus                     |                1                                                         |      3  1.0|
      Degeneration                         |    1                                               1                     |     12  1.2|
      Eosinophilic Focus                   |                            1                                             |      2  1.0|
      Fatty Change                         | 1                 1                                                      |     16  1.3|
      Fibrosis                             |                   1                                                      |      1  1.0|
      Hematopoietic Cell Proliferation     |                                                                          |      2  1.0|
      Hepatodiaphragmatic Nodule           |          X                                                               |      3  2.0|
      Inflammation, Chronic, Granulomatous |                                                                          |      2  1.0|
      Inflammation, Chronic Active         | 1                 1        1        1                                    |     10  1.0|
      Mixed Cell Focus                     |                                              1                           |      2  1.0|
      Necrosis, Coagulative                | 1                          2        1                 2                  |     10  1.2|
      Pigmentation                         |                                                                          |      3  1.0|
      Regeneration                         |                                                 3                        |      4  2.8|
      Bile Duct, Hyperplasia               | 1  1  3  2     1     2     1  1  2  1  2     1  2  1  1  1               |     56  1.4|
      Periportal, Inflammation, Chronic    | 1                          1        1                                    |     10  1.0|
      Periportal, Inflammation, Chronic    |                                                                          |            |
          Active                           |          1                                1              1               |     11  1.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |       +                                                                  |   3        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  87                                                               
NTP Experiment-Test: 05061-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 11:03:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 5| 4| 7| 4| 7| 5| 4| 7| 7| 4| 5| 2| 7| 7| 7| 7| 5|              |            |
                             DAY ON TEST   | 5| 3| 2| 4| 2| 3| 2| 3| 7| 5| 3| 3| 5| 7| 7| 3| 3| 3| 3| 6|              |            |
                                           | 8| 4| 1| 9| 1| 4| 7| 4| 4| 6| 1| 1| 6| 3| 5| 4| 1| 3| 5| 2|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |      A     |
    UNTREATE                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |      L     |
    D 71 UM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Chronic Active         |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Atrophy                              |                      2     1              2  1  2  1  1  1               |     17  1.4|
      Ectopic Tissue                       |                                                                          |      1     |
      Infiltration Cellular, Mononuclear   |                                                                          |            |
          Cell                             |                                           1                              |      3  1.3|
      Inflammation, Chronic                |                            1        1                                    |      9  1.0|
      Inflammation, Chronic Active         |                         1                    1  1  2  1                  |     11  1.2|
      Necrosis, Coagulative                |                                                                          |      2  1.0|
      Pigmentation                         |                                           1                              |      1  1.0|
      Vacuolization Cytoplasmic            |    1                 1        1  1              1     1                  |     17  1.2|
      Acinus, Atrophy                      |                                                                          |      1  2.0|
      Artery, Polyarteritis                |                      3                                                   |      4  3.0|
      Duct, Hyperplasia                    |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  69        |
      Hyperkeratosis                       |                                                                          |      5  2.4|
      Hyperplasia, Basal Cell              |          1     1                 1              1                        |     11  1.5|
      Hyperplasia, Squamous                |                                                                          |      3  1.7|
      Inflammation, Chronic Active         |                                                                          |      3  2.0|
      Ulcer                                |                                                                          |      3  2.7|
      Muscularis, Mineralization           |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Inflammation, Chronic                |                            1                                             |      1  1.0|
      Inflammation, Chronic Active         |                                  2           1                           |      3  1.3|
      Mucosa, Necrosis, Coagulative        |                                                                          |      1  1.0|
      Muscularis, Mineralization           |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Cardiomyopathy                       | 2  2  2  2  2  1  2  2  1  1  2  2  2     2  2  2  2  2                  |     66  1.6|
      Thrombosis                           |                                  4           4                           |      2  4.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Angiectasis                          |                                                    3                     |      2  2.0|
      Hematopoietic Cell Proliferation     |                                                                          |      2  1.0|
      Hyperplasia                          |                                                       2                  |      5  2.0|
      Necrosis, Coagulative                |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  88                                                               
NTP Experiment-Test: 05061-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 11:03:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 5| 4| 7| 4| 7| 5| 4| 7| 7| 4| 5| 2| 7| 7| 7| 7| 5|              |            |
                             DAY ON TEST   | 5| 3| 2| 4| 2| 3| 2| 3| 7| 5| 3| 3| 5| 7| 7| 3| 3| 3| 3| 6|              |            |
                                           | 8| 4| 1| 9| 1| 4| 7| 4| 4| 6| 1| 1| 6| 3| 5| 4| 1| 3| 5| 2|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |      A     |
    UNTREATE                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |      L     |
    D 71 UM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Vacuolization Cytoplasmic            |          1     1     1           2     2        1        2               |     23  1.6|
      Bilateral, Vacuolization Cytoplasmic |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  69        |
      Fibrosis                             |                                                    3                     |      1  3.0|
      Hematopoietic Cell Proliferation     |                                                                          |      1  1.0|
      Hyperplasia                          |    2           2                 2           2  2     2                  |     18  1.7|
      Necrosis, Coagulative                |                                                    4                     |      2  3.0|
      Bilateral, Hyperplasia               |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |    +  +  +  +  +  +  +  +     +  +     +     +  +  +  +  +               |  54        |
      Hemorrhage                           |                                                                          |      1  1.0|
      Hyperplasia                          |                      1                                                   |      1  1.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +               |  63        |
      Hyperplasia                          |                                                 3  3                     |      4  3.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  65        |
      Pars Distalis, Cyst                  |                                        1                                 |      7  1.1|
      Pars Distalis, Hyperplasia           | 1  1              1        1        1        1  1     2                  |     23  1.3|
      Pars Intermedia, Cyst                |                                                                          |      2  1.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  69        |
      Inflammation, Chronic Active         |       1                                                                  |      2  1.0|
      C-Cell, Hyperplasia                  |       1                          1                                       |     11  1.0|
      Follicle, Cyst                       |                      2                          2                        |      2  2.0|
      Follicular Cell, Hyperplasia         |                                                                          |      3  1.3|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Coagulating Gland                       |                                  +                                       |   2        |
      Inflammation, Chronic Active         |                                  4                                       |      1  4.0|
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Aspermia                             |                                                 4                        |      1  4.0|
      Inflammation, Chronic Active         |                                                       1                  |      3  1.0|
      Vacuolization Cytoplasmic            |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +               |  67        |
      Abscess                              |                                                                          |      6  2.3|
      Cyst                                 |                                  3                                       |      2  3.0|
      Inflammation, Chronic                |                                     2                                    |      7  1.4|
      Inflammation, Chronic Active         | 2  2  1  1  1  1  1  2  2     3  2     2  1  1  3  2  1  1               |     57  1.7|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  89                                                               
NTP Experiment-Test: 05061-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 11:03:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 5| 4| 7| 4| 7| 5| 4| 7| 7| 4| 5| 2| 7| 7| 7| 7| 5|              |            |
                             DAY ON TEST   | 5| 3| 2| 4| 2| 3| 2| 3| 7| 5| 3| 3| 5| 7| 7| 3| 3| 3| 3| 6|              |            |
                                           | 8| 4| 1| 9| 1| 4| 7| 4| 4| 6| 1| 1| 6| 3| 5| 4| 1| 3| 5| 2|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |      A     |
    UNTREATE                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |      L     |
    D 71 UM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Acute                  |                                                                          |      2  1.0|
      Inflammation, Chronic Active         | 1  1        2              2                 3  2                        |     17  2.4|
      Metaplasia, Squamous                 |                                                                          |      1  2.0|
      Epithelium, Hyperplasia              |                                                       1                  |      8  1.1|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  69        |
      Atrophy                              |                                                    3                     |      1  3.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Polyarteritis                        |                                                                          |      1  2.0|
      Interstitial Cell, Hyperplasia       | 1     1  1     1  2     1  2        1                 1  1               |     27  1.3|
      Seminiferous Tubule, Atrophy         | 3  4           3     4        4  3     1     4  4  4  4                  |     43  3.4|
      Seminiferous Tubule, Mineralization  |                                  2     1                                 |      8  1.1|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Sternal, Myelofibrosis               |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |    +  +              +           +     +  M     +                        |  19        |
      Mediastinal, Hemorrhage              |                                                                          |      2  2.0|
      Mediastinal, Pigmentation            |                                                                          |      1  1.0|
      Mediastinal, Sinus, Ectasia          |    2                                                                     |      1  2.0|
      Renal, Hemorrhage                    |                                                                          |      1  2.0|
      Renal, Infiltration Cellular,        |                                                                          |            |
          Histiocyte                       |                                                                          |      1  4.0|
      Renal, Pigmentation                  |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Hemorrhage                           |                            1        3     3                              |     12  2.1|
      Hyperplasia                          |                1                                   2  2                  |     11  2.4|
      Infiltration Cellular, Histiocyte    |                                                                          |      2  1.0|
      Inflammation, Chronic Active         |                                                          2               |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  68        |
      Depletion Lymphoid                   |                                                                          |      1  3.0|
      Hemorrhage                           |                            1                                             |      1  1.0|
      Infiltration Cellular, Histiocyte    | 2  1     2  1  1  1  1  2  1  1  1  2     1  1  1  1  1  1               |     64  1.1|
      Pigmentation                         |                            1        1                                    |     10  1.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Depletion Lymphoid                   |                                  3              4  2                     |     12  2.9|
      Fibrosis                             |    2                    1                                                |      6  1.8|
      Necrosis, Coagulative                |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  M  +  +  +  +  M  +  +  +  M  +  +  +  +  M  M  +  +               |  56        |
      Cyst                                 |                                                                          |      3  1.3|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  90                                                               
NTP Experiment-Test: 05061-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 11:03:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 5| 4| 7| 4| 7| 5| 4| 7| 7| 4| 5| 2| 7| 7| 7| 7| 5|              |            |
                             DAY ON TEST   | 5| 3| 2| 4| 2| 3| 2| 3| 7| 5| 3| 3| 5| 7| 7| 3| 3| 3| 3| 6|              |            |
                                           | 8| 4| 1| 9| 1| 4| 7| 4| 4| 6| 1| 1| 6| 3| 5| 4| 1| 3| 5| 2|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |      A     |
    UNTREATE                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |      L     |
    D 71 UM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Depletion Lymphoid                   |                                                                          |      3  2.3|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  M  M  +  M  +  +  +  +  M  M  M  M  M  +  M  M  +  +  M               |  39        |
      Galactocele                          |                                                                          |      3  2.0|
      Hyperplasia                          |          2     1                          1        2                     |     25  1.8|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Cyst Epithelial Inclusion            |                                                                          |      1  3.0|
      Fibrosis                             |                                                                          |      1  2.0|
      Inflammation, Chronic Active         |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |       +                                                                  |   2        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Infarct                              |                                        3                                 |      3  1.7|
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                        +                                 |   5        |
      Infarct                              |                                        3                                 |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Crystals                             |                                                                          |      1  1.0|
      Infiltration Cellular, Histiocyte    | 1        1     1        1     1  1                                       |     24  1.0|
      Necrosis, Coagulative                |       2                                                                  |      1  2.0|
      Alveolar Epithelium, Hyperplasia     |                                                 2                        |      7  1.6|
      Alveolus, Mineralization             |                                                                          |      1  1.0|
      Artery, Mineralization               | 1  1              1  1        1     1  1  1  1     1                     |     36  1.0|
      Artery, Thrombosis                   |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +               |  68        |
      Autolysis                            |                                                                          |      1  3.0|
      Inflammation, Chronic Active         |          2     1        4                             2  4               |     26  2.3|
      Metaplasia, Squamous                 |          2                                               2               |     10  2.0|
      Ulcer                                |                                                                          |      2  2.0|
      Glands, Hyperplasia                  |                                                                          |      9  1.3|
      Glands, Inflammation, Acute          |                            1                                             |      3  1.0|
      Glands, Inflammation, Chronic Active |                                                                          |      1  1.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  91                                                               
NTP Experiment-Test: 05061-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 11:03:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 5| 4| 7| 4| 7| 5| 4| 7| 7| 4| 5| 2| 7| 7| 7| 7| 5|              |            |
                             DAY ON TEST   | 5| 3| 2| 4| 2| 3| 2| 3| 7| 5| 3| 3| 5| 7| 7| 3| 3| 3| 3| 6|              |            |
                                           | 8| 4| 1| 9| 1| 4| 7| 4| 4| 6| 1| 1| 6| 3| 5| 4| 1| 3| 5| 2|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |      A     |
    UNTREATE                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |      L     |
    D 71 UM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
           Chronic Active                  |                                                                          |      1  2.0|
      Respiratory Epithelium, Hyperplasia  |                         2                                                |      2  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                           +                              |   4        |
      Acanthosis                           |                                                                          |      1  2.0|
      Hyperkeratosis                       |                                                                          |      1  2.0|
      Hyperplasia, Basal Cell              |                                                                          |      1  2.0|
      Inflammation, Chronic Active         |                                           2                              |      2  1.5|
      Ulcer                                |                                           2                              |      1  2.0|
                                            __________________________________________________________________________|____________|
   Eye                                     |          +           +                 +                                 |   6        |
      Anterior, Synechia                   |          4                                                               |      1  4.0|
      Cornea, Inflammation, Chronic Active |          3                                                               |      1  3.0|
      Retina, Degeneration                 |          4                                                               |      1  4.0|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Autolysis                            |                                                                          |      2  3.0|
      Cyst                                 |                      1                                                   |      4  1.0|
      Cyst, Multiple                       |                                                                          |      1  3.0|
      Granuloma                            |                                                                          |      1  2.0|
      Hydronephrosis                       |       1                                                                  |      1  1.0|
      Inflammation, Chronic                |                                                                          |      4  1.0|
      Nephropathy                          | 2  4  3  3  1  3  2  3  3  2  3  3  2  2     3  3  4  2  2               |     60  2.7|
      Renal Tubule, Hyperplasia            |          1     1     1                       3     4                     |      9  2.2|
      Renal Tubule, Inflammation, Chronic  |                                                                          |            |
          Active                           |    1           1     1        1              1        1                  |     14  1.0|
      Renal Tubule, Mineralization         |                                                    2                     |      1  2.0|
      Renal Tubule, Pigmentation           |                                                                          |      5  2.0|
      Renal Tubule, Regeneration           |                                           1                              |     10  1.0|
      Transitional Epithelium, Hyperplasia |    2  1  2     2     2        1  1                 1                     |     30  1.4|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Calculus Micro Observation Only      |                                                                          |      2  2.5|
      Hemorrhage                           |                                        4                                 |      2  3.0|
      Hyperplasia, Lymphoid                |                                                                          |      4  1.3|
      Inflammation, Chronic Active         |                                                       1                  |      1  1.0|
      Serosa, Mineralization               |                                                                          |      1  1.0|
      Transitional Epithelium, Hyperplasia |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  92                                                               
NTP Experiment-Test: 05061-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 11:03:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 2| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 2| 7| 7| 7| 7| 2|             
                             DAY ON TEST   | 3| 3| 7| 0| 7| 3| 3| 1| 5| 1| 3| 3| 3| 2| 9| 3| 3| 3| 2| 7| 3| 3| 3| 3| 7|             
                                           | 1| 1| 3| 4| 6| 4| 4| 8| 3| 8| 4| 4| 4| 0| 3| 1| 1| 1| 9| 6| 1| 1| 1| 1| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.2%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
     71LM                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                      2                                                   |             
      Parasite Metazoan                    |                1           X     1  1           1  1        1  1  1  1   |             
      Polyarteritis                        |                                                                   2      |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    | 1                 1                                         1            |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                      3                                                   |             
      Inflammation, Chronic Active         |                            2                                             |             
      Parasite Metazoan                    |    1           1  1           1                                1     1   |             
      Ulcer, Acute                         |                            1                                             |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                      1                                                   |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Autolysis                            |                      3                                                   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                      1                                                   |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     |       1        1     2  1  1  2  4     3  1     1                        |             
      Clear Cell Focus                     | 1  1           2  2  1     1     2  2        2  3              1  4  2   |             
      Degeneration                         |          1                                                               |             
      Eosinophilic Focus                   |                            4        3  4     4  2              4         |             
      Fatty Change                         |    1        1           1  1                             1               |             
      Hepatodiaphragmatic Nodule           |                                                             X            |             
      Infarct                              |                                                                          |             
      Inflammation, Chronic Active         |                            1                                             |             
      Mixed Cell Focus                     | 1                             4  1        4  4              3     3      |             
      Necrosis, Coagulative                |       1              3                                1                 1|             
      Pigmentation                         | 1     1        1  1        1           1           1  1  1  1  1  1  1   |             
      Bile Duct, Cyst                      |                                     3                                    |             
      Bile Duct, Hyperplasia               | 1                          1                       1  1                  |             
      Periportal, Inflammation, Chronic    |                                                                          |             
          Active                           |             1              1                             1              1|             
                                            __________________________________________________________________________|             
   Mesentery                               |             M                                            M              M|             
      Fibrosis                             |                                                                          |             
      Inflammation, Chronic, Granulomatous |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Necrosis, Coagulative                |                                                                          |             
      Polyarteritis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 2  1  2  2        1     2  1  2     1  1  3     1  2  3     2  1  2  1  2|             
      Infiltration Cellular, Mononuclear   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  93                                                               
NTP Experiment-Test: 05061-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 11:03:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 2| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 2| 7| 7| 7| 7| 2|             
                             DAY ON TEST   | 3| 3| 7| 0| 7| 3| 3| 1| 5| 1| 3| 3| 3| 2| 9| 3| 3| 3| 2| 7| 3| 3| 3| 3| 7|             
                                           | 1| 1| 3| 4| 6| 4| 4| 8| 3| 8| 4| 4| 4| 0| 3| 1| 1| 1| 9| 6| 1| 1| 1| 1| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.2%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
     71LM                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
          Cell                             |                                                          1              1|             
      Infiltration Cellular, Mixed Cell    |                                                                          |             
      Inflammation, Chronic Active         | 1  1  1        1  1     1  1  1     1  1  2  1  1  1  1     1  1  1  1   |             
      Vacuolization Cytoplasmic            |                                        1                                 |             
      Artery, Polyarteritis                |                                           4     2  4           2         |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |    2  2                 2  2              2  2     1  2        2     2   |             
      Hyperplasia, Basal Cell              |    2  2                 2  2              2  2     2  2        2     2   |             
      Hyperplasia, Squamous                |    3  3                 3  3           3  2  4     4  2        3     3   |             
      Inflammation, Chronic Active         |    1  1                    3              2  4     2           2     4   |             
      Ulcer                                |                         4              3     4        4        2     4   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                       2                  |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Cardiomyopathy                       | 2  3  2     1  2  1  3  2  1  3  2  1  2  2  2  2  2  1  1  2  1  1  2   |             
      Polyarteritis                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                      1           1                             1         |             
      Hyperplasia                          |          1                                                               |             
      Vacuolization Cytoplasmic            |    2  2                    1           1     2     1  2           1  2   |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 1  2  2        2     2  1     2        2  1  1  1  2        2            |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  M  +  +  +|             
      Hyperplasia                          |       2                 2              2  1  2  2  2              1  2   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  | 1                                         2                       2      |             
      Pars Distalis, Hyperplasia           |          2     1  1     1                    1                           |             
      Pars Intermedia, Cyst                |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Mononuclear   |                                                                          |             
          Cell                             |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Ultimobranchial Cyst                 |                                                                          |             
      C-Cell, Hyperplasia                  |       1                                   1           2     1            |             
      Follicle, Cyst                       | 1                                                                        |             
      Follicular Cell, Hyperplasia         |          1                                                               |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  94                                                               
NTP Experiment-Test: 05061-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 11:03:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 2| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 2| 7| 7| 7| 7| 2|             
                             DAY ON TEST   | 3| 3| 7| 0| 7| 3| 3| 1| 5| 1| 3| 3| 3| 2| 9| 3| 3| 3| 2| 7| 3| 3| 3| 3| 7|             
                                           | 1| 1| 3| 4| 6| 4| 4| 8| 3| 8| 4| 4| 4| 0| 3| 1| 1| 1| 9| 6| 1| 1| 1| 1| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.2%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
     71LM                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       |       +                                                                  |             
      Inflammation, Chronic Active         |       4                                                                  |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                                          |             
      Inflammation, Chronic Active         |    2  2  2     2  2  2  2  2  1  2  2  2  2  2  2     2     2  2  2  2  1|             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                       4                  |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic Active         | 2     4     1        2     3     3              2  4           4         |             
      Metaplasia, Squamous                 |       4                          2                 4                     |             
      Polyarteritis                        |                                                                          |             
      Epithelium, Hyperplasia              | 1                                               1           2            |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |    3  2        2  2  2  2     2  2     3  2  3  3           3  3  3  3   |             
      Inflammation, Chronic Active         |                                                    4  4                  |             
      Metaplasia, Squamous                 |                                                    4                     |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infarct                              |                                                                          |             
      Mineralization                       |                                                                          |             
      Interstitial Cell, Hyperplasia       |             1              1                             1              1|             
      Seminiferous Tubule, Atrophy         | 4  4  4  3     4  4  4  3  2  4  4  4  4  4  4  4  4        3  4  4  4   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |          +  M           +                    +        +  M               |             
      Lumbar, Hyperplasia                  |                                                       2                  |             
      Mediastinal, Infiltration Cellular,  |                                                                          |             
           Histiocyte                      |                                                                          |             
      Pancreatic, Hyperplasia              |                                              2                           |             
      Pancreatic, Infiltration Cellular,   |                                                                          |             
           Histiocyte                      |                         1                    1                           |             
      Renal, Hemorrhage                    |                                                                          |             
      Renal, Pigmentation                  |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |             2                                            1              1|             
      Hyperplasia                          | 2  2                          2     2                 4                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Infiltration Cellular, Histiocyte    | 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  2  1  1  1  1  1|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Depletion Lymphoid                   |             2                                                  1         |             
      Fibrosis                             | 2                       1                                                |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  95                                                               
NTP Experiment-Test: 05061-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 11:03:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 2| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 2| 7| 7| 7| 7| 2|             
                             DAY ON TEST   | 3| 3| 7| 0| 7| 3| 3| 1| 5| 1| 3| 3| 3| 2| 9| 3| 3| 3| 2| 7| 3| 3| 3| 3| 7|             
                                           | 1| 1| 3| 4| 6| 4| 4| 8| 3| 8| 4| 4| 4| 0| 3| 1| 1| 1| 9| 6| 1| 1| 1| 1| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.2%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
     71LM                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  M  +  +  +  +  +  M  +  +  +  M  M  +  +  M  M  +  +  +  +  +  +|             
      Depletion Lymphoid                   |             2                                            2               |             
      Hemorrhage                           |                                                                         2|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  +  +  +  M  M  +  M  M  +  M  +  M  M  +  M  +  +  +  M  +  +  M  +  +|             
      Galactocele                          |                                                       2                  |             
      Hyperplasia                          |    2  2                    1     2        2        2  2     2  1     3  2|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  I  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                           4                              |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Rib, Hyperostosis                    |                                                       2                  |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Polyarteritis                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spinal Cord                             |          +                                                               |             
      Infarct                              |          3                                                               |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Histiocyte    |    1  1        1  1              1  1  1        1  1  1        1  1  1   |             
      Inflammation, Chronic Active         |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                                                         1|             
      Artery, Mineralization               | 1  1                       1  1     1     1  1              1            |             
      Mediastinum, Polyarteritis           |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                                                          |             
      Inflammation, Chronic Active         | 1  3  4        1           4  2  3  4  4  3  4  1                 1  1   |             
      Metaplasia, Squamous                 |    2  2                    2  1        2                                 |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                      +  +  +           +        +     +                  |             
      Acanthosis                           |                                        2                                 |             
      Hyperplasia, Basal Cell              |                                        2                                 |             
                                            __________________________________________________________________________|             
   Eye                                     |                         I                                                |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                       +                  |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  96                                                               
NTP Experiment-Test: 05061-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 11:03:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 2| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 2| 7| 7| 7| 7| 2|             
                             DAY ON TEST   | 3| 3| 7| 0| 7| 3| 3| 1| 5| 1| 3| 3| 3| 2| 9| 3| 3| 3| 2| 7| 3| 3| 3| 3| 7|             
                                           | 1| 1| 3| 4| 6| 4| 4| 8| 3| 8| 4| 4| 4| 0| 3| 1| 1| 1| 9| 6| 1| 1| 1| 1| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.2%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
     71LM                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                        2           2                     |             
      Fibrosis, Focal                      |                                                                          |             
      Infiltration Cellular, Mononuclear   |                                                                          |             
          Cell                             |             1                                            1              1|             
      Nephropathy                          | 3  4  4  3     2  4  4  4  4  3  4  3  4  4  4  3  4  4     4  4  3  4   |             
      Renal Tubule, Degeneration, Hyaline  |             2                                            2              2|             
      Renal Tubule, Hyperplasia            |    4  3        1  4  4  4     4     4  4     4  2  3        2        4   |             
      Renal Tubule, Hyperplasia, Oncocytic |                                                                          |             
      Renal Tubule, Inflammation, Chronic  |                                                                          |             
          Active                           | 1                                   1        1                    1      |             
      Renal Tubule, Mineralization         |                2                                                         |             
      Renal Tubule, Pigmentation           | 2  2  2  2  1  2  2  2  2  1  2  2  2  2  2  1  1  2  2  1  2  2  2  2  1|             
      Renal Tubule, Regeneration           |             1                                            1              1|             
      Transitional Epithelium, Hyperplasia | 2  2  3  2     2  2  2  1  1  2  2  4  4  2  1  2  2  4     1  2  2  1   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Edema                                |                                                       3                  |             
      Fibrosis                             |                1                                                         |             
      Inflammation, Chronic Active         |       2                                                                  |             
      Polyarteritis                        |                                                                          |             
      Transitional Epithelium, Hyperplasia | 2     2                                               2                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  97                                                               
NTP Experiment-Test: 05061-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 11:03:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 6| 2| 7| 7| 7| 6| 2| 6| 6| 2| 2| 2| 7| 7| 7| 7| 7| 7| 6| 6| 2| 2|            |
                             DAY ON TEST   | 3| 0| 7| 5| 7| 3| 3| 3| 7| 7| 5| 4| 7| 7| 7| 3| 3| 3| 3| 3| 3| 9| 6| 7| 7|            |
                                           | 1| 0| 4| 9| 6| 4| 4| 4| 5| 4| 0| 0| 6| 5| 4| 1| 1| 0| 0| 0| 4| 4| 8| 4| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    0.2%                                   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      L     |
     71LM                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Autolysis                            |                                                                          |      1  2.0|
      Parasite Metazoan                    |                      1        1     1     1        1     1           1   |     17  1.0|
      Polyarteritis                        |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    | 1                 1                       1              1           1   |      8  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Autolysis                            |                                                                          |      1  3.0|
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Parasite Metazoan                    |                                                       1  1               |      8  1.0|
      Ulcer, Acute                         |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Autolysis                            |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Autolysis                            |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Autolysis                            |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          | 3                                               2              1         |      3  2.0|
      Basophilic Focus                     |                      1           2                                       |     12  1.7|
      Clear Cell Focus                     | 2  2  2  1     1  2           1                 1  3  2  2  2  3         |     26  1.8|
      Degeneration                         | 2              2                                                         |      3  1.7|
      Eosinophilic Focus                   | 1  3           2     2                                      3  4  2      |     13  2.9|
      Fatty Change                         |             1              1     1  1                                1  1|     11  1.0|
      Hepatodiaphragmatic Nodule           |                                                    X                     |      2     |
      Infarct                              |                                                                   3      |      1  3.0|
      Inflammation, Chronic Active         |                                                                          |      1  1.0|
      Mixed Cell Focus                     |    2           4  2     1                    2  2  2     4  1  2         |     17  2.5|
      Necrosis, Coagulative                | 1                                1                                3  1   |      8  1.5|
      Pigmentation                         |    1                 1  1                    1     1     2        2      |     20  1.1|
      Bile Duct, Cyst                      |                                                                          |      1  3.0|
      Bile Duct, Hyperplasia               | 2        1              1  1     1           1                           |     10  1.1|
      Periportal, Inflammation, Chronic    |                                                                          |            |
          Active                           |             1              1     1  1  1  1                          1  1|     12  1.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |       +     M     +        +        M  M  M                          M  M|   3        |
      Fibrosis                             |       2           2                                                      |      2  2.0|
      Inflammation, Chronic, Granulomatous |                            3                                             |      1  3.0|
      Inflammation, Chronic Active         |       2           2                                                      |      2  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  98                                                               
NTP Experiment-Test: 05061-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 11:03:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 6| 2| 7| 7| 7| 6| 2| 6| 6| 2| 2| 2| 7| 7| 7| 7| 7| 7| 6| 6| 2| 2|            |
                             DAY ON TEST   | 3| 0| 7| 5| 7| 3| 3| 3| 7| 7| 5| 4| 7| 7| 7| 3| 3| 3| 3| 3| 3| 9| 6| 7| 7|            |
                                           | 1| 0| 4| 9| 6| 4| 4| 4| 5| 4| 0| 0| 6| 5| 4| 1| 1| 0| 0| 0| 4| 4| 8| 4| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    0.2%                                   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      L     |
     71LM                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Necrosis, Coagulative                |       3                    3                                             |      2  3.0|
      Polyarteritis                        |       4                                                                  |      1  4.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |    2     1     2  1     2     2  3                 1                     |     27  1.7|
      Infiltration Cellular, Mononuclear   |                                                                          |            |
          Cell                             |                                     1     1                          1   |      5  1.0|
      Infiltration Cellular, Mixed Cell    |                            1                                             |      1  1.0|
      Inflammation, Chronic Active         |    1     1     1  1     1     2  2           1     1                     |     28  1.1|
      Vacuolization Cytoplasmic            |                                                          1               |      2  1.0|
      Artery, Polyarteritis                |       4              4        4                          3               |      8  3.4|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperkeratosis                       |    2  2        1        2     2                 1           2     2      |     18  1.8|
      Hyperplasia, Basal Cell              |    2  2        2        1     2                 1           3     2      |     18  1.9|
      Hyperplasia, Squamous                |    3  3        3        1     3                 3           4     4      |     19  3.0|
      Inflammation, Chronic Active         |       3                       2                             2     3      |     12  2.4|
      Ulcer                                |       2                       3                             2     4      |     10  3.2|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |                                  1                                       |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Autolysis                            |          2                                                               |      1  2.0|
      Cardiomyopathy                       | 3  2  3     1  2  2  2  2  1  2  1  1     2  1  1  1  2  2  2  2  2  1  1|     46  1.7|
      Polyarteritis                        |       3                                                                  |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |    2                                               1                     |      5  1.2|
      Hyperplasia                          |                                                                          |      1  1.0|
      Vacuolization Cytoplasmic            |       1  2              2     1  2              1  1     1  2            |     18  1.5|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          | 2     2        1        2     1  1              1     1  2  3  2  2      |     25  1.6|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +     +  +  +  +     +  +           +  +  +  +  +  +  +  +      |  40        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|  45        |
      Hyperplasia                          |    2                 2  2                                                |     12  1.8|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pars Distalis, Cyst                  |    1                                                                     |      4  1.5|
      Pars Distalis, Hyperplasia           |    2     1              1              1  1  2  1        2           1  2|     15  1.3|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  99                                                               
NTP Experiment-Test: 05061-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 11:03:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 6| 2| 7| 7| 7| 6| 2| 6| 6| 2| 2| 2| 7| 7| 7| 7| 7| 7| 6| 6| 2| 2|            |
                             DAY ON TEST   | 3| 0| 7| 5| 7| 3| 3| 3| 7| 7| 5| 4| 7| 7| 7| 3| 3| 3| 3| 3| 3| 9| 6| 7| 7|            |
                                           | 1| 0| 4| 9| 6| 4| 4| 4| 5| 4| 0| 0| 6| 5| 4| 1| 1| 0| 0| 0| 4| 4| 8| 4| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    0.2%                                   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      L     |
     71LM                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Pars Intermedia, Cyst                |                                                                2         |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infiltration Cellular, Mononuclear   |                                                                          |            |
          Cell                             |                                     1                                    |      1  1.0|
      Inflammation, Chronic Active         |                      1                                                   |      1  1.0|
      Ultimobranchial Cyst                 |                      2                                         1        1|      3  1.3|
      C-Cell, Hyperplasia                  |       1           1                             1           1            |      8  1.1|
      Follicle, Cyst                       |                                                                          |      1  1.0|
      Follicular Cell, Hyperplasia         |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Coagulating Gland                       |                                                       +                  |   2        |
      Inflammation, Chronic Active         |                                                       3                  |      2  3.5|
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |                      2                                1                  |      2  1.5|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Abscess                              |                                                                   4      |      1  4.0|
      Inflammation, Chronic Active         | 2  2  2  2  1  2  2  1  2     2  2  1  1     2  2  1  2  2  2  2  2  1  1|     44  1.8|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Abscess                              |                                                          4  3            |      3  3.7|
      Inflammation, Acute                  |                                                                      2  3|      2  2.5|
      Inflammation, Chronic Active         | 2  1           2     2  3  1  2     2     2  2  2     4           2      |     22  2.4|
      Metaplasia, Squamous                 | 1  1                 1        1                 2     3  4  3            |     11  2.4|
      Polyarteritis                        |       3                                                                  |      1  3.0|
      Epithelium, Hyperplasia              |                1                                                         |      4  1.3|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              | 2  3  3  3     3     3  2     3              3  3  3        4  3  2      |     30  2.7|
      Inflammation, Chronic Active         |                                                          2               |      3  3.3|
      Metaplasia, Squamous                 |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infarct                              |                                                          3               |      1  3.0|
      Mineralization                       |                                     1                                    |      1  1.0|
      Interstitial Cell, Hyperplasia       |                         1  1     1  1  1  1                          1  1|     12  1.0|
      Seminiferous Tubule, Atrophy         | 3  4  4  4     4  4  4  3     3              4  4  3  4     4  4  3      |     37  3.7|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 100                                                               
NTP Experiment-Test: 05061-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 11:03:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 6| 2| 7| 7| 7| 6| 2| 6| 6| 2| 2| 2| 7| 7| 7| 7| 7| 7| 6| 6| 2| 2|            |
                             DAY ON TEST   | 3| 0| 7| 5| 7| 3| 3| 3| 7| 7| 5| 4| 7| 7| 7| 3| 3| 3| 3| 3| 3| 9| 6| 7| 7|            |
                                           | 1| 0| 4| 9| 6| 4| 4| 4| 5| 4| 0| 0| 6| 5| 4| 1| 1| 0| 0| 0| 4| 4| 8| 4| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    0.2%                                   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      L     |
     71LM                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |             +              M     +  M  M  M                          M  M|   6        |
      Lumbar, Hyperplasia                  |                                                                          |      1  2.0|
      Mediastinal, Infiltration Cellular,  |                                                                          |            |
           Histiocyte                      |                                  1                                       |      1  1.0|
      Pancreatic, Hyperplasia              |                                                                          |      1  2.0|
      Pancreatic, Infiltration Cellular,   |                                                                          |            |
           Histiocyte                      |                                                                          |      2  1.0|
      Renal, Hemorrhage                    |             1                                                            |      1  1.0|
      Renal, Pigmentation                  |             1                                                            |      1  1.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |             1                          1                                 |      5  1.2|
      Hyperplasia                          |                   2     2                                                |      7  2.3|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                        1                                 |      1  1.0|
      Infiltration Cellular, Histiocyte    | 1  1  1  1  1  1  1  1  1  1  1  1  2  1  1  1  1  1  1  1  1  1  1  1  1|     50  1.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Depletion Lymphoid                   |                      2                                                   |      3  1.7|
      Fibrosis                             |          2                                                               |      3  1.7|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  M  +  +|  41        |
      Depletion Lymphoid                   |                                     2                                   3|      4  2.3|
      Hemorrhage                           |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  M  +  +  M  M  M  M  +  +  M  +  +  +  +  +  +  M  M  +  +  M  M  +|  29        |
      Galactocele                          |                                                                          |      1  2.0|
      Hyperplasia                          | 1  1        1              2  2     2  1  1  1  2  1        2  2        1|     25  1.6|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Abscess                              |    3                                                                     |      2  3.5|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Rib, Hyperostosis                    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |       +                                                                  |   1        |
      Polyarteritis                        |       4                                                                  |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 101                                                               
NTP Experiment-Test: 05061-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 11:03:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 6| 2| 7| 7| 7| 6| 2| 6| 6| 2| 2| 2| 7| 7| 7| 7| 7| 7| 6| 6| 2| 2|            |
                             DAY ON TEST   | 3| 0| 7| 5| 7| 3| 3| 3| 7| 7| 5| 4| 7| 7| 7| 3| 3| 3| 3| 3| 3| 9| 6| 7| 7|            |
                                           | 1| 0| 4| 9| 6| 4| 4| 4| 5| 4| 0| 0| 6| 5| 4| 1| 1| 0| 0| 0| 4| 4| 8| 4| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    0.2%                                   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      L     |
     71LM                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Infarct                              |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infiltration Cellular, Histiocyte    | 1        1     1     1        1     1           1        1     1  1      |     23  1.0|
      Inflammation, Chronic Active         |       1                                                                  |      1  1.0|
      Alveolar Epithelium, Hyperplasia     |          1                                                               |      2  1.0|
      Artery, Mineralization               |                         1           1  1     1  1  1     1  1        1   |     17  1.0|
      Mediastinum, Polyarteritis           |       4                                      2                           |      2  3.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Foreign Body                         |       2                                                        1         |      2  1.5|
      Inflammation, Chronic Active         |    1  2        1  1  3  2        4           2              2  3  1      |     25  2.3|
      Metaplasia, Squamous                 |                      2           3                                       |      7  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |       2                                                                  |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |          +                                                               |   7        |
      Acanthosis                           |                                                                          |      1  2.0|
      Hyperplasia, Basal Cell              |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Eye                                     |                   +                             +  +                     |   3        |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                                                   2      |      3  2.0|
      Fibrosis, Focal                      |                3                                                         |      1  3.0|
      Infiltration Cellular, Mononuclear   |                                                                          |            |
          Cell                             |                            1        1  1  1                          1  1|      9  1.0|
      Nephropathy                          | 4  4  4  3     4  3  4  4     4  4           3  3  3  4  3  3  4  4      |     40  3.6|
      Renal Tubule, Degeneration, Hyaline  |             2              2        2  2  2                          2  2|     10  2.0|
      Renal Tubule, Hyperplasia            | 3  2  2  3        2     2     3  3           3  4  1  3  1  3  2  1      |     30  2.8|
      Renal Tubule, Hyperplasia, Oncocytic |                                                 2                        |      1  2.0|
      Renal Tubule, Inflammation, Chronic  |                                                                          |            |
          Active                           |       1  1     1  1                                   1           1      |     10  1.0|
      Renal Tubule, Mineralization         |                         1                                                |      2  1.5|
      Renal Tubule, Pigmentation           | 2  2  2  2  1  2  2  2  2  1  2  2  1  2  1  2  2  2  2  2  2  2  2  1  1|     50  1.8|
      Renal Tubule, Regeneration           |             2              1        2  2  1                          2  2|     10  1.5|
      Transitional Epithelium, Hyperplasia | 2  2  2  2     1  1  2  2     2  2           2  2  1  3  3  3  2  2      |     40  2.1|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 102                                                               
NTP Experiment-Test: 05061-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 11:03:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 6| 2| 7| 7| 7| 6| 2| 6| 6| 2| 2| 2| 7| 7| 7| 7| 7| 7| 6| 6| 2| 2|            |
                             DAY ON TEST   | 3| 0| 7| 5| 7| 3| 3| 3| 7| 7| 5| 4| 7| 7| 7| 3| 3| 3| 3| 3| 3| 9| 6| 7| 7|            |
                                           | 1| 0| 4| 9| 6| 4| 4| 4| 5| 4| 0| 0| 6| 5| 4| 1| 1| 0| 0| 0| 4| 4| 8| 4| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    0.2%                                   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      L     |
     71LM                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  48        |
      Edema                                |                                                                          |      1  3.0|
      Fibrosis                             |                                                                          |      1  1.0|
      Inflammation, Chronic Active         |                      1                                2                  |      3  1.7|
      Polyarteritis                        |       1                                                                  |      1  1.0|
      Transitional Epithelium, Hyperplasia |                                                       2  2               |      5  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 103                                                               
NTP Experiment-Test: 05061-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 11:03:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 6| 7| 7| 5| 2| 2| 7| 7| 6| 6| 5| 7| 7| 7| 7| 6| 7| 7| 6| 6| 2|             
                             DAY ON TEST   | 2| 2| 2| 6| 5| 2| 1| 2| 7| 7| 2| 2| 9| 7| 7| 2| 2| 2| 1| 5| 2| 2| 2| 0| 7|             
                                           | 9| 9| 0| 1| 3| 9| 2| 1| 4| 4| 9| 9| 3| 4| 6| 9| 9| 9| 4| 0| 9| 9| 3| 9| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.5%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    71MLM                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                   3                                      2  2            |             
      Hyperplasia, Lymphoid                |                                                    2                     |             
      Parasite Metazoan                    |                1        1           1           1                    1   |             
      Polyarteritis                        |                2                                                         |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Atypia Cellular                      |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Parasite Metazoan                    | 1              1                 2                                   1   |             
      Artery, Neovascularization           |                2                                                         |             
      Artery, Thrombosis                   |                2                                                         |             
      Epithelium, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atypia Cellular                      |                                                                          |             
      Autolysis                            |                   3                                      2               |             
      Hyperplasia, Lymphoid                |                                        2                                 |             
      Parasite Metazoan                    | 1                                   1                       1  1         |             
      Lymphoid Tissue, Hemorrhage          |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                   1                                   1  4               |             
      Ectopic Tissue                       |                                                                      3   |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |          1        4                                   1  4               |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |          1  1                                            4               |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |    3     2  1  1              4           2     1                 1      |             
      Clear Cell Focus                     | 1  3  2  1     1              3     2  1     1  1  1        2  1  4  1   |             
      Cyst                                 |                                                                          |             
      Degeneration                         |                                     1     1  1     1                     |             
      Eosinophilic Focus                   |       2  1  4  1                    3  3        3                        |             
      Fatty Change                         |          2                 1                                1           1|             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Infarct                              |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Mixed Cell Focus                     |                                  2        2  3                           |             
      Necrosis, Coagulative                | 1  1              3  3                                                   |             
      Pigmentation                         | 1  1  1  2  1                 1  1  1  1  1  1  1     1     1  1  1  1   |             
      Bile Duct, Hyperplasia               | 2  2  1  1  1  1  1  1           2  1  1  1  1  1  1  1     1  1  1  1   |             
      Periportal, Inflammation, Chronic    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 104                                                               
NTP Experiment-Test: 05061-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 11:03:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 6| 7| 7| 5| 2| 2| 7| 7| 6| 6| 5| 7| 7| 7| 7| 6| 7| 7| 6| 6| 2|             
                             DAY ON TEST   | 2| 2| 2| 6| 5| 2| 1| 2| 7| 7| 2| 2| 9| 7| 7| 2| 2| 2| 1| 5| 2| 2| 2| 0| 7|             
                                           | 9| 9| 0| 1| 3| 9| 2| 1| 4| 4| 9| 9| 3| 4| 6| 9| 9| 9| 4| 0| 9| 9| 3| 9| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.5%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    71MLM                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
          Active                           | 1  1  1  1  1  1  1     1  1  1  2  1  1  1  1  1  1  1     1  1  1  1  1|             
                                            __________________________________________________________________________|             
   Mesentery                               |    +                                            +                        |             
      Fibrosis                             |    2                                            4                        |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Chronic Active         |    2                                            2                        |             
      Necrosis, Coagulative                |    2                                            3                        |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |    2     1  2  2     2                    2  1  1                 1      |             
      Autolysis                            |                                                          2               |             
      Infiltration Cellular, Mononuclear   |                                                                          |             
          Cell                             |                            1                                             |             
      Inflammation, Chronic Active         | 1  1  1  1  1  2  1  1        1     1  1  1  1  1     1     1  1  1      |             
      Vacuolization Cytoplasmic            |                               2                    1  2                  |             
      Acinus, Hyperplasia                  |                                                                          |             
      Artery, Fibrosis                     |                                                                   4      |             
      Artery, Polyarteritis                | 4                                                  2  1                  |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parotid Gland, Inflammation, Chronic |                                        1                                 |             
      Submandibular Gland, Inflammation,   |                                                                          |             
           Chronic                         |                                     1  1                                 |             
      Submandibular Gland, Metaplasia,     |                                                                          |             
           Squamous                        |                                     1                                    |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                          |             
      Fibrosis                             |                                                                          |             
      Hyperkeratosis                       |       2  2                    2     2                             2  1   |             
      Hyperplasia, Basal Cell              |       2  2                          1  1        1        1  2        2   |             
      Hyperplasia, Squamous                |       4  3                    3     3                       4     3  3   |             
      Infarct                              |                                                             4            |             
      Inflammation, Chronic Active         |       2                       2                                      2   |             
      Ulcer                                |          3                    2     3                       4     3      |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                          2               |             
      Inflammation, Chronic Active         |             1                                                            |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                           +                              |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1  2  2  1  1  2  1  3  1     2  1  1  2  1  2  1  1  1  2  2  2  2  2  1|             
      Metaplasia, Osseous                  |                      2                                                   |             
      Thrombosis                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page 105                                                               
NTP Experiment-Test: 05061-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 11:03:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 6| 7| 7| 5| 2| 2| 7| 7| 6| 6| 5| 7| 7| 7| 7| 6| 7| 7| 6| 6| 2|             
                             DAY ON TEST   | 2| 2| 2| 6| 5| 2| 1| 2| 7| 7| 2| 2| 9| 7| 7| 2| 2| 2| 1| 5| 2| 2| 2| 0| 7|             
                                           | 9| 9| 0| 1| 3| 9| 2| 1| 4| 4| 9| 9| 3| 4| 6| 9| 9| 9| 4| 0| 9| 9| 3| 9| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.5%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    71MLM                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Angiectasis                          | 1  2  1     2  1                             1     1              1      |             
      Hyperplasia                          |                                  1     2                                 |             
      Vacuolization Cytoplasmic            |       1     1     1           1                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    2     2     1     1        2  1     1     1  1     1              3   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Autolysis                            |                                                          2               |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  | 1        2                                         2                    1|             
      Pars Distalis, Hyperplasia           |    1  2  2                       2        3           2     2     1      |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                   2                                      3               |             
      Inflammation, Chronic Active         |                                                                          |             
      Ultimobranchial Cyst                 |                                                                          |             
      C-Cell, Hyperplasia                  |                                                 1                        |             
      Follicle, Cyst                       |                   2                    2              2                  |             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                   2                                      2               |             
      Inflammation, Chronic Active         |             2  1                 1  2        1     1  1        1         |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Abscess                              |                                                       2                  |             
      Cyst                                 |                                                                          |             
      Hyperplasia                          | 2  2                                                                     |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         | 2  2  2  1  2  2  2  1     1  2  2  2  2  2  1  2  1  2  3  2  1  1  1   |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                                          |             
      Inflammation, Chronic Active         | 1  2        1  1     2  3        3  2     1  2           2  2            |             
      Metaplasia, Squamous                 |                                                                          |             
      Epithelium, Hyperplasia              |                                                             1            |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 3  3  2  2  2  3  3           3  3  3     3  3  3  3  3     3            |             
      Autolysis                            |                                                          3               |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 106                                                               
NTP Experiment-Test: 05061-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 11:03:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 6| 7| 7| 5| 2| 2| 7| 7| 6| 6| 5| 7| 7| 7| 7| 6| 7| 7| 6| 6| 2|             
                             DAY ON TEST   | 2| 2| 2| 6| 5| 2| 1| 2| 7| 7| 2| 2| 9| 7| 7| 2| 2| 2| 1| 5| 2| 2| 2| 0| 7|             
                                           | 9| 9| 0| 1| 3| 9| 2| 1| 4| 4| 9| 9| 3| 4| 6| 9| 9| 9| 4| 0| 9| 9| 3| 9| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.5%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    71MLM                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Interstitial Cell, Hyperplasia       |             1     1  1     1     1     1        1     1              1  1|             
      Seminiferous Tubule, Atrophy         | 4  4  4  2  3  4  4  3        4  4  4  2  3  4  4  4  3  3  4  4  4  4   |             
      Seminiferous Tubule, Mineralization  |                      1                                                   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Sternal, Autolysis                   |                                                          2               |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                         +  M     +              +     +                 +|             
      Lumbar, Pigmentation                 |                                                                          |             
      Mediastinal, Hemorrhage              |                                                                         2|             
      Pancreatic, Hemorrhage               |                         2                                                |             
      Pancreatic, Hyperplasia              |                                                                          |             
      Pancreatic, Infiltration Cellular,   |                                                                          |             
           Histiocyte                      |                                  2              1     1                  |             
      Pancreatic, Inflammation, Chronic    |                                                                          |             
          Active                           |                                                                          |             
      Renal, Infiltration Cellular,        |                                                                          |             
          Histiocyte                       |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                         3  1                                             |             
      Hyperplasia                          |                   1              2        2                    3         |             
      Infiltration Cellular, Histiocyte    |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                   1                                                      |             
      Hyperplasia                          |                                                                          |             
      Infiltration Cellular, Histiocyte    | 1  1  2  1  1  1  1  2  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1|             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                          2               |             
      Fibrosis                             |                                  3     2                                 |             
      Hyperplasia, Re Cell                 |                                                                2         |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  M  +  M  M  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Depletion Lymphoid                   |                         2                                                |             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  +  M  M  M  +  M  +  M  M  +  +  +  M  +  M  M  M  M  M  +  +  +|             
      Galactocele                          |                                        4                                 |             
      Hyperplasia                          |                      1     2        2  1  2     1                       2|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                          4               |             
      Cyst Epithelial Inclusion            |                                     2                    X           2   |             
      Inflammation, Chronic Active         |                                     3                                    |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 107                                                               
NTP Experiment-Test: 05061-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 11:03:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 6| 7| 7| 5| 2| 2| 7| 7| 6| 6| 5| 7| 7| 7| 7| 6| 7| 7| 6| 6| 2|             
                             DAY ON TEST   | 2| 2| 2| 6| 5| 2| 1| 2| 7| 7| 2| 2| 9| 7| 7| 2| 2| 2| 1| 5| 2| 2| 2| 0| 7|             
                                           | 9| 9| 0| 1| 3| 9| 2| 1| 4| 4| 9| 9| 3| 4| 6| 9| 9| 9| 4| 0| 9| 9| 3| 9| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.5%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    71MLM                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Joint, Tarsal, Hyperostosis          |                                                                          |             
      Joint, Tarsal, Inflammation, Chronic |                                                                          |             
          Active                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                     +                                    |             
      Fibrosis                             |                                     2                                    |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |       +                                                                  |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
      Infiltration Cellular, Histiocyte    | 1  1  1  1        1  2              1  1     1  1     1     1        1  1|             
      Inflammation, Chronic Active         | 1                                      2                       1         |             
      Alveolar Epithelium, Hyperplasia     |                                                 1     1                  |             
      Artery, Mineralization               |       1  1     1  1     1  1     1  1  1  1     1  1  1  1        1  1   |             
      Bronchiole, Epithelium, Hyperplasia  |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         | 2                                                           1            |             
      Inflammation, Chronic Active         | 3                    1        1  1     2     1        3  4  3  4         |             
      Metaplasia, Squamous                 |                                                       2  2  1  2         |             
      Respiratory Epithelium, Hyperplasia  |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                        2                       1         |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
      Acanthosis                           |                                                                          |             
      Hyperplasia, Basal Cell              |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Cataract                             |                                                                          |             
      Retina, Degeneration                 |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                           +                              |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                          3               |             
      Cyst                                 |                                                                          |             
      Infiltration Cellular, Mononuclear   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 108                                                               
NTP Experiment-Test: 05061-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 11:03:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 6| 7| 7| 5| 2| 2| 7| 7| 6| 6| 5| 7| 7| 7| 7| 6| 7| 7| 6| 6| 2|             
                             DAY ON TEST   | 2| 2| 2| 6| 5| 2| 1| 2| 7| 7| 2| 2| 9| 7| 7| 2| 2| 2| 1| 5| 2| 2| 2| 0| 7|             
                                           | 9| 9| 0| 1| 3| 9| 2| 1| 4| 4| 9| 9| 3| 4| 6| 9| 9| 9| 4| 0| 9| 9| 3| 9| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.5%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    71MLM                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
          Cell                             |                            1                                            1|             
      Nephropathy                          | 3  3  2  2  3  3  4  3        3  3  4  3  2  3  3  3  3  2  2  3  3  4   |             
      Collecting Tubule, Mineralization    |                                                                          |             
      Renal Tubule, Degeneration, Hyaline  |                         2  2                                            2|             
      Renal Tubule, Hyperplasia            |    1     4     2  4              4                             3     4   |             
      Renal Tubule, Inflammation, Chronic  |                                                                          |             
          Active                           |    1        1     1           1     1  1     1  1  1  1     1            |             
      Renal Tubule, Mineralization         |                   1           1     1        1     1                     |             
      Renal Tubule, Pigmentation           | 2  2  2  2  2  2  2  2  1  2  2  2  2  2  2  2  2  2  2  2  2  2  2     2|             
      Renal Tubule, Regeneration           |                         1  2                                            2|             
      Transitional Epithelium, Hyperplasia | 2  2  1  1  2  1  3  1        1  2  3  2     2  3  3  1  1  2  3  2  2   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                          4               |             
      Calculus Micro Observation Only      |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Transitional Epithelium, Hyperplasia |                                  2              2  1  1     2  2     2   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 109                                                               
NTP Experiment-Test: 05061-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 11:03:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 2| 7| 7| 6| 6| 2| 6| 5| 4| 2| 2| 7| 6| 6| 5| 2| 6| 6| 6| 2| 2|             
                             DAY ON TEST   | 2| 2| 0| 6| 7| 2| 0| 7| 2| 7| 5| 8| 7| 7| 7| 3| 7| 3| 8| 7| 5| 3| 3| 7| 7|             
                                           | 9| 9| 0| 3| 6| 9| 2| 4| 9| 5| 0| 4| 8| 4| 4| 0| 4| 7| 2| 6| 9| 6| 6| 5| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.5%                                   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    71MLM                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Parasite Metazoan                    | 1           1                                1           2               |             
      Polyarteritis                        |                                                                          |             
      Ulcer                                |                                                       2                  |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atypia Cellular                      |                                                 2                        |             
      Inflammation, Chronic Active         |                                                       3                  |             
      Parasite Metazoan                    |                1                                                         |             
      Artery, Neovascularization           |                                                                          |             
      Artery, Thrombosis                   |                                                                          |             
      Epithelium, Hyperplasia              |                                                       4                  |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atypia Cellular                      |                               2                                          |             
      Autolysis                            |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Parasite Metazoan                    |    1     1  2                                   1                        |             
      Lymphoid Tissue, Hemorrhage          |                            1                                             |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Ectopic Tissue                       |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     | 2                    1  2        4  2                          4        1|             
      Clear Cell Focus                     | 2  2  1           2     2     1              1     1           4  4      |             
      Cyst                                 |                                                                          |             
      Degeneration                         | 1                                                           1            |             
      Eosinophilic Focus                   |          3                       1                                       |             
      Fatty Change                         |          2                             1  1        1  1  1  2        1   |             
      Hematopoietic Cell Proliferation     | 2              1                                                         |             
      Hemorrhage                           |                                                       2                  |             
      Infarct                              |                                                                4         |             
      Inflammation, Chronic Active         |                                  2  1                 2                  |             
      Mixed Cell Focus                     |                                                                          |             
      Necrosis, Coagulative                |                                                       2                  |             
      Pigmentation                         | 1  1     1     1  1     1     1  1           1  1  1        2  2  1      |             
      Bile Duct, Hyperplasia               | 1  1  1  2     2  1  1  1     1     1        1  2  1  2     1  2  1      |             
      Periportal, Inflammation, Chronic    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 110                                                               
NTP Experiment-Test: 05061-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 11:03:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 2| 7| 7| 6| 6| 2| 6| 5| 4| 2| 2| 7| 6| 6| 5| 2| 6| 6| 6| 2| 2|             
                             DAY ON TEST   | 2| 2| 0| 6| 7| 2| 0| 7| 2| 7| 5| 8| 7| 7| 7| 3| 7| 3| 8| 7| 5| 3| 3| 7| 7|             
                                           | 9| 9| 0| 3| 6| 9| 2| 4| 9| 5| 0| 4| 8| 4| 4| 0| 4| 7| 2| 6| 9| 6| 6| 5| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.5%                                   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    71MLM                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
          Active                           | 1     1  1  1  1  1  1  1  1  1        1  1  1  2  1     1  1  1  1  1  1|             
                                            __________________________________________________________________________|             
   Mesentery                               |                   +                                                      |             
      Fibrosis                             |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Chronic Active         |                   3                                                      |             
      Necrosis, Coagulative                |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |    1              1  1  1     1                    1           1         |             
      Autolysis                            |                                                                          |             
      Infiltration Cellular, Mononuclear   |                                                                          |             
          Cell                             |                            1                                             |             
      Inflammation, Chronic Active         | 1  2     1     1  1     1     1     1        1              1  1         |             
      Vacuolization Cytoplasmic            |    1  1                                                                  |             
      Acinus, Hyperplasia                  |                                                                          |             
      Artery, Fibrosis                     |                                                                          |             
      Artery, Polyarteritis                |                2                                                         |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Parotid Gland, Inflammation, Chronic |                                                                          |             
      Submandibular Gland, Inflammation,   |                                                                          |             
           Chronic                         |                                                                          |             
      Submandibular Gland, Metaplasia,     |                                                                          |             
           Squamous                        |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                         2                                                |             
      Fibrosis                             |                                                       3                  |             
      Hyperkeratosis                       |       2        2  2  2  2                       2  3        2     2      |             
      Hyperplasia, Basal Cell              |                2  2  2  3           1           2           2     1      |             
      Hyperplasia, Squamous                |       3        3  3  3  4           3           4  3  4     3     3      |             
      Infarct                              |                                                                          |             
      Inflammation, Chronic Active         |       3                             3                 2                  |             
      Ulcer                                |       1        3  4  2                             3  3     3     2      |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Inflammation, Chronic Active         |                                     2                                    |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                    +                     |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 2  2  2  2  1  1  1  2  1  2  1  1        1  1  1     2  1  2  1  1  1  1|             
      Metaplasia, Osseous                  |                                                                          |             
      Thrombosis                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page 111                                                               
NTP Experiment-Test: 05061-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 11:03:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 2| 7| 7| 6| 6| 2| 6| 5| 4| 2| 2| 7| 6| 6| 5| 2| 6| 6| 6| 2| 2|             
                             DAY ON TEST   | 2| 2| 0| 6| 7| 2| 0| 7| 2| 7| 5| 8| 7| 7| 7| 3| 7| 3| 8| 7| 5| 3| 3| 7| 7|             
                                           | 9| 9| 0| 3| 6| 9| 2| 4| 9| 5| 0| 4| 8| 4| 4| 0| 4| 7| 2| 6| 9| 6| 6| 5| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.5%                                   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    71MLM                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Angiectasis                          |       2                                                                  |             
      Hyperplasia                          |                                                                          |             
      Vacuolization Cytoplasmic            | 1  1  2        1  1           2              1  1     1     1     1      |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    3              2  2        2                             2  1         |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +     +  +  +  +     +  +  A        +  +  +  +     +  +  +      |             
      Autolysis                            |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |                      2        2                                          |             
      Pars Distalis, Hyperplasia           | 1     1  2        2              2  1  1           1  1           1      |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Inflammation, Chronic Active         |                                     1                                    |             
      Ultimobranchial Cyst                 |                                     1  1              1                  |             
      C-Cell, Hyperplasia                  |    1                 1                             1           1         |             
      Follicle, Cyst                       |                               1                 2           2            |             
      Follicular Cell, Hyperplasia         |                      2                                      3            |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Inflammation, Chronic Active         |                                              1                           |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                                          |             
      Cyst                                 |                                                                          |             
      Hyperplasia                          |                                                                          |             
      Inflammation, Acute                  |                            1                                             |             
      Inflammation, Chronic                |             1                                                            |             
      Inflammation, Chronic Active         | 1  1     1     1     2  1     2  1  2        2  2  1  2     2  2  1     2|             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              | 4                                                                        |             
      Inflammation, Chronic Active         |                3     2        2     2                                    |             
      Metaplasia, Squamous                 | 4                    2        2                                          |             
      Epithelium, Hyperplasia              |                   1                                                      |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 3     3        3  2  3                       2  2           2            |             
      Autolysis                            |                                                                          |             
      Inflammation, Chronic Active         | 1                                                                        |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                          1               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 112                                                               
NTP Experiment-Test: 05061-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/17/97  
Route: DOSED FEED                                                                                                 Time: 11:03:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 2| 7| 7| 6| 6| 2| 6| 5| 4| 2| 2| 7| 6| 6| 5| 2| 6| 6| 6| 2| 2|             
                             DAY ON TEST   | 2| 2| 0| 6| 7| 2| 0| 7| 2| 7| 5| 8| 7| 7| 7| 3| 7| 3| 8| 7| 5| 3| 3| 7| 7|             
                                           | 9| 9| 0| 3| 6| 9| 2| 4| 9| 5| 0| 4| 8| 4| 4| 0| 4| 7| 2| 6| 9| 6| 6| 5| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.5%                                   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    71MLM                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Interstitial Cell, Hyperplasia       |          1           2  1  1  1     2  1           1     1  1  1  1      |             
      Seminiferous Tubule, Atrophy         |    4  4  2     4  4  4  3     4  4           4  3  4  4     4  3  3      |             
      Seminiferous Tubule, Mineralization  |                                     1                                    |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Sternal, Autolysis                   |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +           M  +        +  M           +  +              +     +     +  M|             
      Lumbar, Pigmentation                 |                                           1                              |             
      Mediastinal, Hemorrhage              |                                        1  1              1               |             
      Pancreatic, Hemorrhage               |                                                                          |             
      Pancreatic, Hyperplasia              | 2                                                                        |             
      Pancreatic, Infiltration Cellular,   |                                                                          |             
           Histiocyte                      |                         2                                      3     2   |             
      Pancreatic, Inflammation, Chronic    |                                                                          |             
          Active                           |                                                                      2   |             
      Renal, Infiltration Cellular,        |                                                                          |             
          Histiocyte                       |                                                                2         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  M  +  +  +  +  +  +|             
      Hemorrhage                           |                            3           1  1              3              2|             
      Hyperplasia                          | 2              2                                               3         |             
      Infiltration Cellular, Histiocyte    |             1           2                                                |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Hyperplasia                          |                                                                   2      |             
      Infiltration Cellular, Histiocyte    | 1  1     1  1  1  1  1  1  1  2  1  1  1  1  1  1  1  2  1  1  1  2  1  1|             
      Pigmentation                         |                                           1                              |             
                                            _______________________