National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/1758

TR 383 Rat Pathology Tables

NTP                                         STATISTICAL ANALYSIS OF SURVIVAL DATA                              REPORT: PEIRPT11     
LAB: Mason                                          1-AMINO 2,4-DIBROMOANTHRAQUINONE                           DATE: 05/19/95       
EXPERIMENT: 05061 TEST: 01                                                                                     TIME: 15:26:42       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: N01ES9561903                              ROUTE: DOSED FEED                                              NTP C#: 55458        
PATHOLOGIST: R. FLEISCHMAN                                                                                     CAS: 81-49-2         
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    


               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  

NTP                                         STATISTICAL ANALYSIS OF SURVIVAL DATA                              REPORT: PEIRPT11    
LAB: Mason                                          1-AMINO 2,4-DIBROMOANTHRAQUINONE                           DATE: 05/19/95      
EXPERIMENT: 05061 TEST: 01                                                                                     TIME: 15:26:42      
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                       
CONT: N01ES9561903                              ROUTE: DOSED FEED                                              NTP C#: 55458       
PATHOLOGIST: R. FLEISCHMAN                                                                                     CAS: 81-49-2        

                         1-AMINO 2,4-DIBROMOANTHRAQUINONE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE RATS
                       FIRST TERMINAL SACRIFICE AT 729 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                          DOSE = UNTREATED 71 UM                                |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 70     UNCENSORED DEATHS 24     CENSORED DEATHS 20   TERMINAL 26        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      421   427   435   514   549   556   562   573   574   587                 |
 |      631   646   654   666   671   674   674   679   692   696                 |
 |      707   721   721   727                                                     |
 |  CENSORED DEATHS                                                               |
 |      273   274   275   275   275   275   276   276   276   276                 |
 |      456   456   456   456   456   456   456   458   458   458                 |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 0.2%     71                              |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 16     CENSORED DEATHS 10   TERMINAL 24        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      604   618   629   640   650   653   659   668   673   674                 |
 |      675   693   694   700   718   720                                         |
 |  CENSORED DEATHS                                                               |
 |      274   274   274   274   275   276   276   276   276   276                 |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 0.5%    71M                              |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 70     UNCENSORED DEATHS 39     CENSORED DEATHS 10   TERMINAL 21        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      465   478   521   521   563   576   582   584   605   608                 |
 |      609   623   629   629   636   636   637   650   650   652                 |
 |      653   659   661   674   674   674   685   687   693   698                 |
 |      700   700   702   709   712   714   715   720   728                       |
 |  CENSORED DEATHS                                                               |
 |      274   274   274   274   274   275   275   276   276   276                 |
 |                                                                                |
 ==================================================================================

                         1-AMINO 2,4-DIBROMOANTHRAQUINONE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE RATS
                       FIRST TERMINAL SACRIFICE AT 729 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 1.0%    71M                              |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 70     UNCENSORED DEATHS 40     CENSORED DEATHS 20   TERMINAL 10        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      281   352   364   435   436   476   493   497   527   542                 |
 |      552   553   573   577   581   588   590   591   596   605                 |
 |      610   622   624   625   631   631   646   671   674   674                 |
 |      679   689   702   703   709   714   715   721   724   724                 |
 |  CENSORED DEATHS                                                               |
 |      274   274   274   275   275   275   275   276   276   276                 |
 |      456   456   456   456   456   458   458   458   458   458                 |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 2.0%    71                               |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 30     UNCENSORED DEATHS 3      CENSORED DEATHS 27   TERMINAL 0         |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      400   423   427                                                           |
 |  CENSORED DEATHS                                                               |
 |      273   274   274   274   274   274   274   275   275   275                 |
 |      456   456   456   456   456   456   457   457   457   457                 |
 |      457   457   457   458   458   458   458                                   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 2.0%                                     |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 10     UNCENSORED DEATHS 3      CENSORED DEATHS 7    TERMINAL 0         |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      414   442   447                                                           |
 |  CENSORED DEATHS                                                               |
 |      456   456   458   458   458   458   458                                   |
 |                                                                                |
 ==================================================================================

                         1-AMINO 2,4-DIBROMOANTHRAQUINONE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE RATS
                       FIRST TERMINAL SACRIFICE AT 729 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   729 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |UNTREATED  |   100.0 100.0 100.0 100.0  98.3  95.0  93.0  80.9  74.8  52.6      |
 |71 UM      |                                                                    |
 |           |                                                                    |
 |0.2%     71|   100.0 100.0 100.0 100.0 100.0 100.0 100.0  97.5  82.5  60.0      |
 |           |                                                                    |
 |           |                                                                    |
 |0.5%    71M|   100.0 100.0 100.0 100.0 100.0  96.7  93.3  85.0  61.7  35.0      |
 |           |                                                                    |
 |           |                                                                    |
 |1.0%    71M|   100.0 100.0 100.0  95.0  95.0  89.6  81.5  61.1  46.9  20.4      |
 |           |                                                                    |
 |           |                                                                    |
 |2.0%    71 |   100.0 100.0 100.0 100.0  90.0   0.0   0.0   0.0   0.0   0.0      |
 |           |                                                                    |
 |           |                                                                    |
 |2.0%       |   100.0 100.0 100.0 100.0  90.0   0.0   0.0   0.0   0.0   0.0      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================

                         1-AMINO 2,4-DIBROMOANTHRAQUINONE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE RATS
                       FIRST TERMINAL SACRIFICE AT 729 DAYS


 ===============================================================================================================================
 |                                               SURVIVAL SUMMARY STATISTICS                                                   |
 |                                                                                                                             |
 |                                                                                                                             |
 |-----------------------------------------------------------------------------------------------------------------------------|
 |                                                                          DOSE                                               |
 |                                                                                                                             |
 |                                UNTREATED       0.2%     71     0.5%    71M     1.0%    71M     2.0%    71      2.0%         |
 |                                71 UM                                                                                        |
 |-----------------------------------------------------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       52.6%           60.0%           35.0%           20.4%            0.0%            0.0%        |
 |(KAPLAN-MEIER)          |                                                                                                    |
 |                        |                                                                                                    |
 |SIGNIFICANCE (B)        |       P<0.001         P=0.467N        P=0.141         P<0.001         P=0.303         P=0.041      |
 |(LIFE TABLE)            |                                                                                                    |
 |                        |                                                                                                    |
 |MEAN DAY OF             |       614.9           666.8           641.3           592.4           416.7           434.3        |
 |NATURAL DEATHS (C)      |       (19.3)          ( 8.5)          (10.6)          (17.2)          ( 8.4)          (10.3)       |
 |(STANDARD ERROR)        |                                                                                                    |
 |                        |                                                                                                    |
 |MEAN LIFE SPAN (D)      |       586.1           618.3           615.3           547.2           392.0           450.5        |
 |(STANDARD ERROR)        |       (19.8)          (25.0)          (18.3)          (18.8)          (15.6)          ( 4.4)       |
 |                        |                                                                                                    |
 ===============================================================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                         1-AMINO 2,4-DIBROMOANTHRAQUINONE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE RATS
                       FIRST TERMINAL SACRIFICE AT 729 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                          DOSE = UNTREATED 71UF                                 |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 70     UNCENSORED DEATHS 12     CENSORED DEATHS 20   TERMINAL 38        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      268   601   606   620   642   656   658   675   704   708                 |
 |      716   719                                                                 |
 |  CENSORED DEATHS                                                               |
 |      279   279   279   281   281   281   281   281   281   281                 |
 |      462   462   462   462   462   462   462   462   462   464                 |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 0.2%    71                               |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 8      CENSORED DEATHS 10   TERMINAL 32        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      600   611   616   659   661   664   670   689                             |
 |  CENSORED DEATHS                                                               |
 |      279   279   281   281   281   281   281   281   281   281                 |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 0.5%    71M                              |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 70     UNCENSORED DEATHS 22     CENSORED DEATHS 10   TERMINAL 38        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      575   582   601   606   609   632   642   647   649   649                 |
 |      660   660   667   670   691   695   696   708   714   716                 |
 |      719   725                                                                 |
 |  CENSORED DEATHS                                                               |
 |      279   279   279   279   279   281   281   281   281   281                 |
 |                                                                                |
 ==================================================================================

                         1-AMINO 2,4-DIBROMOANTHRAQUINONE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE RATS
                       FIRST TERMINAL SACRIFICE AT 729 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 1.0%    71M                              |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 69     UNCENSORED DEATHS 37     CENSORED DEATHS 20   TERMINAL 12        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      367   418   460   512   543   559   566   569   576   580                 |
 |      598   600   610   614   616   625   635   636   636   637                 |
 |      638   658   662   662   664   673   674   685   695   702                 |
 |      702   705   714   715   719   720   722                                   |
 |  CENSORED DEATHS                                                               |
 |      279   279   279   279   279   279   279   281   281   281                 |
 |      462   462   462   462   462   462   464   464   464   464                 |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 2.0%    71                               |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 29     UNCENSORED DEATHS 8      CENSORED DEATHS 21   TERMINAL 0         |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      294   299   306   313   426   429   441   461                             |
 |  CENSORED DEATHS                                                               |
 |      279   279   279   279   279   279   279   279   281   281                 |
 |      462   462   462   462   462   464   464   464   464   464                 |
 |      464                                                                       |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 2.0%                                     |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 10     UNCENSORED DEATHS 1      CENSORED DEATHS 9    TERMINAL 0         |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      456                                                                       |
 |  CENSORED DEATHS                                                               |
 |      462   462   462   464   464   464   464   464   464                       |
 |                                                                                |
 ==================================================================================

                         1-AMINO 2,4-DIBROMOANTHRAQUINONE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE RATS
                       FIRST TERMINAL SACRIFICE AT 729 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   729 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |UNTREATED  |   100.0 100.0  98.6  98.6  98.6  98.6  98.6  96.6  86.5  76.4      |
 |71UF       |                                                                    |
 |           |                                                                    |
 |0.2%    71 |   100.0 100.0 100.0 100.0 100.0 100.0 100.0  97.5  85.0  80.0      |
 |           |                                                                    |
 |           |                                                                    |
 |0.5%    71M|   100.0 100.0 100.0 100.0 100.0 100.0 100.0  95.0  80.0  63.3      |
 |           |                                                                    |
 |           |                                                                    |
 |1.0%    71M|   100.0 100.0 100.0 100.0  96.6  94.9  90.8  76.3  49.5  24.8      |
 |           |                                                                    |
 |           |                                                                    |
 |2.0%    71 |   100.0 100.0 100.0  78.9  78.9  57.9   0.0   0.0   0.0   0.0      |
 |           |                                                                    |
 |           |                                                                    |
 |2.0%       |   100.0 100.0 100.0 100.0 100.0  90.0   0.0   0.0   0.0   0.0      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================

                         1-AMINO 2,4-DIBROMOANTHRAQUINONE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE RATS
                       FIRST TERMINAL SACRIFICE AT 729 DAYS


 ===============================================================================================================================
 |                                               SURVIVAL SUMMARY STATISTICS                                                   |
 |                                                                                                                             |
 |                                                                                                                             |
 |-----------------------------------------------------------------------------------------------------------------------------|
 |                                                                          DOSE                                               |
 |                                                                                                                             |
 |                                UNTREATED       0.2%    71      0.5%    71M     1.0%    71M     2.0%    71      2.0%         |
 |                                71UF                                                                                         |
 |-----------------------------------------------------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       76.4%           80.0%           63.3%           24.8%            0.0%            0.0%        |
 |(KAPLAN-MEIER)          |                                                                                                    |
 |                        |                                                                                                    |
 |SIGNIFICANCE (B)        |       P<0.001         P=0.857N        P=0.216         P<0.001         P<0.001         P=0.634      |
 |(LIFE TABLE)            |                                                                                                    |
 |                        |                                                                                                    |
 |MEAN DAY OF             |       631.1           646.3           659.7           623.4           371.1           456.0        |
 |NATURAL DEATHS (C)      |       (35.1)          (11.5)          ( 9.7)          (13.8)          (26.1)          (  . )       |
 |(STANDARD ERROR)        |                                                                                                    |
 |                        |                                                                                                    |
 |MEAN LIFE SPAN (D)      |       610.0           626.1           643.1           568.7           374.4           462.6        |
 |(STANDARD ERROR)        |       (20.4)          (25.1)          (18.5)          (18.6)          (16.3)          ( 0.8)       |
 |                        |                                                                                                    |
 ===============================================================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                                                  1-AMINO 2,4-DIBROMOANTHRAQUINONE
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        UNTREATED 71 UM  = 1
                                                        0.2%     71      = 2
                                                        0.5%    71M      = 3
                                                        1.0%    71M      = 4
                                                        2.0%    71       = 5
                                                        2.0%             = 6

------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

  100 + 1                                            4                  5 61      3                     2
      |                                              4          44         1 1    3 3      3            2 2
      |                                                          4      5  5 1           1                22
      |                                                                      4     4     1 3   1 3 3       2 2
   90 +                                                                   6   6    4  4        111 33        22
      |                                                                                          11 3   3     22
      |                                                                    5      5   4     4                  2 2
      |                                                                                     4 44  1 1   3 3      22
   80 +                                                                                             1     331 1   22
      |                                                                                        4  4        33 11
      |                                                                                           44           1  1
      |                                                                                            44       3 3    2 2
P  70 +                                                                       6   6                 4 4           11 22
E     |                                                                                                       33
R     |                                                                                               44       3 3 1 12  2
C     |                                                                                                44        3 3 11
E  60 +                                                                                                 444           11 2  2
N     |                                                                                                   44       33  1 1
T     |                                                                                                             33   11
      |                                                                                                    44        33   1 1
S  50 +                                                                                                     4 4
U     |                                                                                                       4   4   33
R     |                                                                                                           44   33
V     |
I  40 +                                                                                                                 33
V     |                                                                                                            4 4 4 33
A     |                                                                                                                   3 3
L     |                                                                                                                44
   30 +
      |                                                                                                                 44
      |                                                                                                                  44
      |
   20 +                                                                                                                   4 4
      |
      |
      |
   10 +
      |
      |
      |
    0 +                                                                           5
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 15 obs hidden.

                                                  1-AMINO 2,4-DIBROMOANTHRAQUINONE
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        UNTREATED 71UF   = 1
                                                        0.2%    71       = 2
                                                        0.5%    71M      = 3
                                                        1.0%    71M      = 4
                                                        2.0%    71       = 5
                                                        2.0%             = 6

----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

  100 + 1                                          1  5           4              6                 3   2
      |                                            1              4       4      4                 33  112
      |                                               55                         4       4             31 1
      |                                                                                  4    4         321 31   2
   90 +                                                55                        6       6    4 4           31 1
      |                                                                                         444          331   1
      |                                                 5 5                                       44             221   1
      |                                                                                                       3  32  2 11
   80 +                                                   5                5                       4   4         33  2  11  2
      |                                                                                                4 4        3  3   1  1
      |                                                                                                              33
      |                                                                    55                                         3 3
P  70 +                                                                                                  4 4
E     |                                                                     55                             44           33
R     |                                                                                                                  33
C     |                                                                      5   5                                        3 3
E  60 +                                                                                                     44
N     |                                                                          5       5                   4 4
T     |                                                                                                        4 4
      |
S  50 +                                                                                                          4 4
U     |
R     |                                                                                                            44
V     |                                                                                                             4 44
I  40 +
V     |
A     |                                                                                                                44
L     |                                                                                                                 44
   30 +
      |                                                                                                                  44
      |                                                                                                                   4 4
      |
   20 +
      |
      |
      |
   10 +
      |
      |
      |
    0 +                                                                                  5
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 15 obs hidden.

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