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TR 386 Mouse Pathology Tables

NTP Experiment-Test: 05072-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:26:06




       Facility:  Midwest Research Institute

       Chemical CAS #:  509-14-8

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All






































                                                              Page   1

NTP Experiment-Test: 05072-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:26:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 2| 7| 4| 7| 7| 7| 5| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 6| 7|             
                             DAY ON TEST   | 2| 2| 1| 2| 8| 3| 3| 3| 4| 3| 6| 3| 3| 3| 3| 3| 3| 5| 3| 2| 3| 3| 3| 0| 3|             
                                           | 9| 9| 4| 9| 0| 0| 0| 0| 4| 0| 3| 0| 0| 0| 0| 0| 0| 7| 0| 7| 0| 0| 0| 6| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  A  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Peyer's Patch, Hyperplasia, Lymphoid |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  A  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Inflammation, Focal, Granulomatous   |                                                    4                     |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                                                         X|             
      Eosinophilic Focus                   |                                                                          |             
      Granuloma, Multifocal                |                                           1                              |             
      Hematopoietic Cell Proliferation,    |                                                                          |             
           Multifocal                      |          1                                                               |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      | 2                                      1              1                  |             
      Inflammation, Multifocal, Subacute   |                   1        1                                             |             
      Necrosis, Acute, Multifocal          |                                                    1     3               |             
      Necrosis, Focal, Subacute            |                                                                          |             
      Vacuolization Cytoplasmic, Focal     |                                                                          |             
      Right Lateral Lobe,                  |                                                                          |             
          Hepatodiaphragmatic Nodule       |          X                                                               |             
                                            __________________________________________________________________________|             
   Mesentery                               | +                                                           +           +|             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      | 3                                                           3           2|             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |    1           1                       3                    2     1      |             
      Acinus, Atrophy, Multifocal          |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      | 2        1        2  2  1        3  2        1  1     1  2     1     1   |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  A  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Epithelium, Hyperplasia, Focal       |                   1           2                                          |             
      Epithelium, Hyperplasia, Multifocal  |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  A  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                 +                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05072-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:26:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 2| 7| 4| 7| 7| 7| 5| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 6| 7|             
                             DAY ON TEST   | 2| 2| 1| 2| 8| 3| 3| 3| 4| 3| 6| 3| 3| 3| 3| 3| 3| 5| 3| 2| 3| 3| 3| 0| 3|             
                                           | 9| 9| 4| 9| 0| 0| 0| 0| 4| 0| 3| 0| 0| 0| 0| 0| 0| 7| 0| 7| 0| 0| 0| 6| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Abscess                              |                                                 4                        |             
      Inflammation, Chronic Active         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +     +  +  +  +  +|             
      Cardiomyopathy                       |                                                                          |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |             1                                                            |             
      Inflammation, Acute, Multifocal      |                                                                          |             
      Epicardium, Inflammation, Chronic    |                                                                          |             
          Active, Focal                    |                                                 2                        |             
      Mitral Valve, Bacterium              |                         4                                                |             
      Mitral Valve, Inflammation, Chronic  |                                                                          |             
          Active                           |                         4                                                |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Capsule, Accessory Adrenal Cortical  |                                                                          |             
          Nodule                           |                                                                          |             
      Capsule, Accessory Adrenal Cortical  |                                                                          |             
          Nodule, Multiple                 |                                                                          |             
      Subcapsular, Hyperplasia, Diffuse    |    3                       3                                            3|             
      Subcapsular, Hyperplasia, Focal      |                                                                          |             
      Subcapsular, Hyperplasia, Multifocal | 2        2  2  3  3  2  2     2  3  3  3  2  3  2  2  2  2  2  2  2  2   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Multifocal              |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                                                4        2|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Multifocal              |             2  2           4                                2     2      |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  M  +  +  +  +  M  +  +  M  +  +  +  M  +  +  +  +  +  +  +  M  +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                     4                             4      |             
      Pars Distalis, Angiectasis           |                2                          3                    2     2   |             
      Pars Distalis, Hyperplasia, Focal    |                            2                                2  2         |             
      Pars Distalis, Hyperplasia           |                                                    4                     |             
      Pars Distalis, Hypertrophy, Focal    |                                              2                          3|             
      Pars Distalis, Hypertrophy,          |                                                                          |             
          Multifocal                       |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  A  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |                                                                          |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |                      2                                                   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05072-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:26:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 2| 7| 4| 7| 7| 7| 5| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 6| 7|             
                             DAY ON TEST   | 2| 2| 1| 2| 8| 3| 3| 3| 4| 3| 6| 3| 3| 3| 3| 3| 3| 5| 3| 2| 3| 3| 3| 0| 3|             
                                           | 9| 9| 4| 9| 0| 0| 0| 0| 4| 0| 3| 0| 0| 0| 0| 0| 0| 7| 0| 7| 0| 0| 0| 6| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Inflammation, Acute, Focal           |                1                                                         |             
      Inflammation, Chronic, Multifocal    |                                                 1     3                  |             
      Inflammation, Chronic Active, Focal  |                                                                          |             
      Inflammation, Chronic Active,        |                                                                          |             
          Multifocal                       |                                                                   3      |             
      C-Cell, Hyperplasia, Focal           |                                                                          |             
      Follicle, Cyst, Multiple             |                                                                          |             
      Follicular Cell, Hyperplasia, Diffuse|                                                                          |             
      Follicular Cell, Hyperplasia, Focal  |                                                                          |             
      Follicular Cell, Hyperplasia,        |                                                                          |             
          Multifocal                       |                      3        2                 1     4                  |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |                                                                          |             
      Atrophy                              |                                                                          |             
      Cyst, Multiple                       |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                     4                                3  4|             
      Thrombosis                           |                                                                         3|             
      Interstitium, Hyperplasia            |                                                                          |             
      Periovarian Tissue, Infiltration     |                                                                          |             
          Cellular, Lymphocyte             |    2                                                                     |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenomyosis                          |                                                                          |             
      Amyloid Deposition                   |                                                                          |             
      Angiectasis, Multifocal              |                                              2                           |             
      Hyperplasia, Cystic                  |    2                                                                     |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |                                                                          |             
      Thrombosis                           |                                              1                           |             
      Bilateral, Hyperplasia, Cystic       | 3        3        3  2  2  3  2  3  1  3  4  3  1     2  2  4        4  2|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inguinal, Hyperplasia, Lymphoid      |                                                                          |             
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |             
      Renal, Hemorrhage, Subacute          |                                                    2                     |             
      Renal, Hyperplasia, Lymphoid         |                                                    2                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage, Subacute                 |                                                 1                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05072-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:26:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 2| 7| 4| 7| 7| 7| 5| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 6| 7|             
                             DAY ON TEST   | 2| 2| 1| 2| 8| 3| 3| 3| 4| 3| 6| 3| 3| 3| 3| 3| 3| 5| 3| 2| 3| 3| 3| 0| 3|             
                                           | 9| 9| 4| 9| 0| 0| 0| 0| 4| 0| 3| 0| 0| 0| 0| 0| 0| 7| 0| 7| 0| 0| 0| 6| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hyperplasia, Lymphoid                |                         2              3                                 |             
      Hyperplasia                          |                                                 3                        |             
      Pigmentation, Hemosiderin            |    2                                                                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  M  M  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                     3                                    |             
      Depletion Lymphoid                   |                               4                                          |             
      Hematopoietic Cell Proliferation     |                               2                                          |             
      Hemorrhage, Acute                    |                1     2        2                          2        2      |             
      Hemorrhage, Subacute                 |                                  2                                       |             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Hematopoietic Cell Proliferation     | 1                       3                          4     4               |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Infarct                              |                                                                          |             
      Pigmentation, Hemosiderin            |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis, Focal                   |                                                                          |             
      Depletion Lymphoid                   |                                                    3                     |             
      Ectopic Parathyroid Gland            |                                                          1               |             
      Hyperplasia, Lymphoid                |                                                 2                        |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia, Multifocal                  |                2              4                 2                        |             
      Hyperplasia, Diffuse                 |                2              2                 2     2                  |             
      Inflammation, Chronic Active,        |                                                                          |             
          Multifocal                       |                               2                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active, Focal  |                      2                                                   |             
      Inflammation, Chronic Active,        |                                                                          |             
          Multifocal                       |                                                                      1   |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |                   2  3     X     1           3        2        2        1|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Inflammation, Chronic, Focal         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                               X     X           X                        |             
      Hemorrhage, Multifocal               |                                                                          |             
      Hydrocephalus                        |                                                 2                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05072-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:26:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 2| 7| 4| 7| 7| 7| 5| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 6| 7|             
                             DAY ON TEST   | 2| 2| 1| 2| 8| 3| 3| 3| 4| 3| 6| 3| 3| 3| 3| 3| 3| 5| 3| 2| 3| 3| 3| 0| 3|             
                                           | 9| 9| 4| 9| 0| 0| 0| 0| 4| 0| 3| 0| 0| 0| 0| 0| 0| 7| 0| 7| 0| 0| 0| 6| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Mineralization, Multifocal           |                2  3     2     2  3     2     2        2     2  2  3     2|             
      Perivascular, Infiltration Cellular, |                                                                          |             
           Multifocal, Lymphocyte          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  M  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |             2                    1                                       |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |          2                                                               |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      | 1              2     2              1  2        2     1        1         |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                                                1         |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Diffuse, Histiocyte             |                                                                          |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Focal, Histiocyte               |                                                                          |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Multifocal, Histiocyte          |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lumen, Exudate                       |                   1                                                      |             
      Mucosa, Inflammation, Chronic        |                      2                                                   |             
      Mucosa, Inflammation, Chronic Active | 1                             1                 2                        |             
      Mucosa, Ulcer                        |                                                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Chronic Active                  |                                                                          |             
      Olfactory Epithelium, Atrophy        |          1                                                               |             
      Respiratory Epithelium, Hyperplasia  |                               1                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cytoplasmic Alteration, Multifocal   |                                                          2               |             
      Infiltration Cellular, Lymphocyte    | 1  2     1  2                       2              1  1                  |             
      Inflammation, Acute, Multifocal      |                                                                          |             
      Metaplasia, Focal, Osseous           |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   6                                                               
NTP Experiment-Test: 05072-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:26:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 2| 7| 4| 7| 7| 7| 5| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 6| 7|             
                             DAY ON TEST   | 2| 2| 1| 2| 8| 3| 3| 3| 4| 3| 6| 3| 3| 3| 3| 3| 3| 5| 3| 2| 3| 3| 3| 0| 3|             
                                           | 9| 9| 4| 9| 0| 0| 0| 0| 4| 0| 3| 0| 0| 0| 0| 0| 0| 7| 0| 7| 0| 0| 0| 6| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |                                                    2                     |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |                   1              1                    1  1     2        2|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   7                                                               
NTP Experiment-Test: 05072-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:26:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 6| 7| 6| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 6| 6| 7| 6| 7| 6| 6| 3|            |
                             DAY ON TEST   | 9| 3| 3| 3| 4| 3| 4| 2| 3| 3| 5| 0| 3| 1| 2| 2| 2| 1| 0| 2| 1| 2| 0| 2| 8|            |
                                           | 0| 0| 1| 1| 2| 1| 2| 9| 1| 1| 5| 4| 1| 9| 9| 9| 9| 3| 5| 9| 9| 9| 3| 9| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +     +  +  +  A  A  +|  42        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  47        |
      Peyer's Patch, Hyperplasia, Lymphoid |                                                 2                        |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  M|  45        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  A  +|  45        |
      Inflammation, Focal, Granulomatous   |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Basophilic Focus                     |                                                                          |      1     |
      Eosinophilic Focus                   |                            X           X  X                              |      3     |
      Granuloma, Multifocal                |                                                                          |      1  1.0|
      Hematopoietic Cell Proliferation,    |                                                                          |            |
           Multifocal                      |                                                                          |      1  1.0|
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |                                                 1                        |      4  1.3|
      Inflammation, Multifocal, Subacute   |                   1                                      1               |      4  1.0|
      Necrosis, Acute, Multifocal          |                                                                      2   |      3  2.0|
      Necrosis, Focal, Subacute            |       1           2                                                      |      2  1.5|
      Vacuolization Cytoplasmic, Focal     |                                     2                                    |      1  2.0|
      Right Lateral Lobe,                  |                                                                          |            |
          Hepatodiaphragmatic Nodule       |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   3        |
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |                                                                          |      3  2.7|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |                1           1        2     1     2                        |     10  1.5|
      Acinus, Atrophy, Multifocal          |                   4                                                      |      1  4.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +|  48        |
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |    1  2  2                 2  3  2  2     3     2  1     2  1           1|     26  1.7|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Epithelium, Hyperplasia, Focal       |                                                                          |      2  1.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   8                                                               
NTP Experiment-Test: 05072-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:26:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 6| 7| 6| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 6| 6| 7| 6| 7| 6| 6| 3|            |
                             DAY ON TEST   | 9| 3| 3| 3| 4| 3| 4| 2| 3| 3| 5| 0| 3| 1| 2| 2| 2| 1| 0| 2| 1| 2| 0| 2| 8|            |
                                           | 0| 0| 1| 1| 2| 1| 2| 9| 1| 1| 5| 4| 1| 9| 9| 9| 9| 3| 5| 9| 9| 9| 3| 9| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Epithelium, Hyperplasia, Multifocal  |                                                             3            |      1  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|  47        |
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |                                                       2                  |      1  2.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   | +                                                                        |   2        |
      Abscess                              |                                                                          |      1  4.0|
      Inflammation, Chronic Active         | 2                                                                        |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Cardiomyopathy                       |                                                 1                        |      1  1.0|
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |                                                                          |      1  1.0|
      Inflammation, Acute, Multifocal      |                                                                   2      |      1  2.0|
      Epicardium, Inflammation, Chronic    |                                                                          |            |
          Active, Focal                    |                                                                          |      1  2.0|
      Mitral Valve, Bacterium              |                                                                   4      |      2  4.0|
      Mitral Valve, Inflammation, Chronic  |                                                                          |            |
          Active                           |                                                                   4      |      2  4.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Capsule, Accessory Adrenal Cortical  |                                                                          |            |
          Nodule                           |                                                                      X   |      1     |
      Capsule, Accessory Adrenal Cortical  |                                                                          |            |
          Nodule, Multiple                 |          X                                                               |      1     |
      Subcapsular, Hyperplasia, Diffuse    |                                                                2         |      4  2.8|
      Subcapsular, Hyperplasia, Focal      |             1                                                            |      1  1.0|
      Subcapsular, Hyperplasia, Multifocal | 2  2  2  3     3  3  2  2  2  2  1  1  1  3  3  2  3  3  2  2     2  2   |     43  2.2|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia, Multifocal              |                                                                         2|      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hyperplasia, Focal                   |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia, Multifocal              |                         3     3           1  2     2                     |     10  2.3|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  M  +  +  M  M  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|  39        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cyst                                 |                                                                          |      2  4.0|
      Pars Distalis, Angiectasis           |          2                                      3        4     2         |      8  2.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   9                                                               
NTP Experiment-Test: 05072-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:26:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 6| 7| 6| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 6| 6| 7| 6| 7| 6| 6| 3|            |
                             DAY ON TEST   | 9| 3| 3| 3| 4| 3| 4| 2| 3| 3| 5| 0| 3| 1| 2| 2| 2| 1| 0| 2| 1| 2| 0| 2| 8|            |
                                           | 0| 0| 1| 1| 2| 1| 2| 9| 1| 1| 5| 4| 1| 9| 9| 9| 9| 3| 5| 9| 9| 9| 3| 9| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Pars Distalis, Hyperplasia, Focal    |    3                                                                     |      4  2.3|
      Pars Distalis, Hyperplasia           |                                                                          |      1  4.0|
      Pars Distalis, Hypertrophy, Focal    |                                              2        2        2         |      5  2.2|
      Pars Distalis, Hypertrophy,          |                                                                          |            |
          Multifocal                       |                                                          2               |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Infiltration Cellular, Focal,        |                                                                          |            |
          Lymphocyte                       |                                                 2                        |      1  2.0|
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |                2                                         2               |      3  2.0|
      Inflammation, Acute, Focal           |                                                                          |      1  1.0|
      Inflammation, Chronic, Multifocal    |       2                          2                                       |      4  2.0|
      Inflammation, Chronic Active, Focal  |                                                    2                     |      1  2.0|
      Inflammation, Chronic Active,        |                                                                          |            |
          Multifocal                       |                               1                                          |      2  2.0|
      C-Cell, Hyperplasia, Focal           |                                  2                                       |      1  2.0|
      Follicle, Cyst, Multiple             |                                        1                                 |      1  1.0|
      Follicular Cell, Hyperplasia, Diffuse|                                  4                                       |      1  4.0|
      Follicular Cell, Hyperplasia, Focal  |                                                             2            |      1  2.0|
      Follicular Cell, Hyperplasia,        |                                                                          |            |
          Multifocal                       | 1     3                 3                                                |      7  2.4|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |                                                          +              +|   2        |
      Atrophy                              |                                                          4               |      1  4.0|
      Cyst, Multiple                       |                                                                         3|      1  3.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Cyst                                 |                4           3                       4  4        4         |      8  3.8|
      Thrombosis                           |                                                                          |      1  3.0|
      Interstitium, Hyperplasia            | 2                                                                        |      1  2.0|
      Periovarian Tissue, Infiltration     |                                                                          |            |
          Cellular, Lymphocyte             |    3                          3                                          |      3  2.7|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Adenomyosis                          |                                           2                              |      1  2.0|
      Amyloid Deposition                   |                                                 2                        |      1  2.0|
      Angiectasis, Multifocal              |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  10                                                               
NTP Experiment-Test: 05072-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:26:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 6| 7| 6| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 6| 6| 7| 6| 7| 6| 6| 3|            |
                             DAY ON TEST   | 9| 3| 3| 3| 4| 3| 4| 2| 3| 3| 5| 0| 3| 1| 2| 2| 2| 1| 0| 2| 1| 2| 0| 2| 8|            |
                                           | 0| 0| 1| 1| 2| 1| 2| 9| 1| 1| 5| 4| 1| 9| 9| 9| 9| 3| 5| 9| 9| 9| 3| 9| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia, Cystic                  |                                                                          |      1  2.0|
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |    1                                                                     |      1  1.0|
      Thrombosis                           |                                                                          |      1  1.0|
      Bilateral, Hyperplasia, Cystic       | 2  3  3  3        1        2     1  2        2  2  3  1  3     4        2|     33  2.5|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inguinal, Hyperplasia, Lymphoid      |                               3                 2                        |      2  2.5|
      Mediastinal, Hyperplasia, Lymphoid   |    2                                                                     |      1  2.0|
      Renal, Hemorrhage, Subacute          |                                                                          |      1  2.0|
      Renal, Hyperplasia, Lymphoid         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|  48        |
      Hemorrhage, Subacute                 |                                                                          |      1  1.0|
      Hyperplasia, Lymphoid                |       2                 2     3                          4               |      6  2.7|
      Hyperplasia                          |                                                                          |      1  3.0|
      Pigmentation, Hemosiderin            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  M  +  A  +|  41        |
      Angiectasis                          |                                                                          |      1  3.0|
      Depletion Lymphoid                   |                                                                          |      1  4.0|
      Hematopoietic Cell Proliferation     |                                  2              3  3                     |      4  2.5|
      Hemorrhage, Acute                    |                2                       4        3  2              4      |     10  2.4|
      Hemorrhage, Subacute                 |                                                          2               |      2  2.0|
      Hyperplasia, Lymphoid                |                               2                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  48        |
      Edema                                |             3                                                            |      1  3.0|
      Hematopoietic Cell Proliferation     |             3     2           2  2                                2  4   |     10  2.7|
      Hyperplasia, Lymphoid                |          2                                         2                     |      2  2.0|
      Infarct                              |                      3                                                   |      1  3.0|
      Pigmentation, Hemosiderin            |                                                    1                     |      1  1.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Angiectasis, Focal                   |                                  2                                       |      1  2.0|
      Depletion Lymphoid                   |                                                       3           3  3   |      4  3.0|
      Ectopic Parathyroid Gland            |                                                    X              X      |      3  1.0|
      Hyperplasia, Lymphoid                |                   1                       2                              |      3  1.7|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  11                                                               
NTP Experiment-Test: 05072-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:26:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 6| 7| 6| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 6| 6| 7| 6| 7| 6| 6| 3|            |
                             DAY ON TEST   | 9| 3| 3| 3| 4| 3| 4| 2| 3| 3| 5| 0| 3| 1| 2| 2| 2| 1| 0| 2| 1| 2| 0| 2| 8|            |
                                           | 0| 0| 1| 1| 2| 1| 2| 9| 1| 1| 5| 4| 1| 9| 9| 9| 9| 3| 5| 9| 9| 9| 3| 9| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Ectasia, Multifocal                  |                   2  3                       2     2     1               |      8  2.3|
      Hyperplasia, Diffuse                 |       2        3  3                                                      |      7  2.3|
      Inflammation, Chronic Active,        |                                                                          |            |
          Multifocal                       |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Inflammation, Chronic Active, Focal  |                                                                          |      1  2.0|
      Inflammation, Chronic Active,        |                                                                          |            |
          Multifocal                       |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Fibrous Osteodystrophy               | 3  2                                2                          1         |     13  2.0|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |             +                                               +            |   2        |
      Inflammation, Chronic, Focal         |                                                             3            |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Compression                          |                X  X     X     X  X                 X                     |      9     |
      Hemorrhage, Multifocal               |                                                                      2   |      1  2.0|
      Hydrocephalus                        |                3                                                         |      2  2.5|
      Mineralization, Multifocal           |    1  3  2     2     2  1           2     1  2  2        1  2  1  2      |     26  2.0|
      Perivascular, Infiltration Cellular, |                                                                          |            |
           Multifocal, Lymphocyte          |       2                                                                 1|      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|  46        |
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Infiltration Cellular, Focal,        |                                                                          |            |
          Lymphocyte                       |                                                                          |      1  2.0|
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      | 1        2     2                    2           2        4           2  2|     16  1.8|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |                                        2                                 |      2  1.5|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Diffuse, Histiocyte             |                                        3                                 |      1  3.0|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Focal, Histiocyte               |                                                                4         |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  12                                                               
NTP Experiment-Test: 05072-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:26:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 6| 7| 6| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 6| 6| 7| 6| 7| 6| 6| 3|            |
                             DAY ON TEST   | 9| 3| 3| 3| 4| 3| 4| 2| 3| 3| 5| 0| 3| 1| 2| 2| 2| 1| 0| 2| 1| 2| 0| 2| 8|            |
                                           | 0| 0| 1| 1| 2| 1| 2| 9| 1| 1| 5| 4| 1| 9| 9| 9| 9| 3| 5| 9| 9| 9| 3| 9| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Multifocal, Histiocyte          |                                                 2                        |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Lumen, Exudate                       |                                        1                       1         |      3  1.0|
      Mucosa, Inflammation, Chronic        |                               2                                          |      2  2.0|
      Mucosa, Inflammation, Chronic Active | 2     1                    1                       1  4  1               |      9  1.6|
      Mucosa, Ulcer                        |                            1                                             |      1  1.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Chronic Active                  |                                                    2                     |      1  2.0|
      Olfactory Epithelium, Atrophy        |                                                    2                     |      2  1.5|
      Respiratory Epithelium, Hyperplasia  |                            1                                             |      2  1.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                |                      2           3                                       |      2  2.5|
      Inflammation, Chronic Active         |                                     2                       2            |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                          +               |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cytoplasmic Alteration, Multifocal   |                                                                          |      1  2.0|
      Infiltration Cellular, Lymphocyte    |    2  2  3     1        2  1  4  2           1  3  1                 1  4|     20  1.9|
      Inflammation, Acute, Multifocal      |                                                                   3      |      1  3.0|
      Metaplasia, Focal, Osseous           |                         2                                                |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +|  48        |
      Infiltration Cellular, Focal,        |                                                                          |            |
          Lymphocyte                       |                            2     1                                       |      3  1.7|
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |    2  2  2     1              1     1  1        2        1  2  1  1      |     18  1.4|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  13                                                               
NTP Experiment-Test: 05072-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:26:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 2| 7| 4| 7| 7| 7|             
                             DAY ON TEST   | 2| 3| 2| 2| 8| 2| 2| 2| 2| 1| 2| 0| 2| 2| 0| 8| 1| 2| 3| 6| 3| 4| 0| 3| 3|             
                                           | 9| 5| 9| 9| 6| 9| 9| 1| 9| 4| 9| 3| 9| 9| 3| 1| 2| 9| 0| 1| 0| 6| 5| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    2 PPM                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | M  A  M  +  A  +  +  A  +  +  +  +  +  +  M  A  A  +  +  M  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  A  +  +  A  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
      Peyer's Patch, Hyperplasia, Lymphoid |                   2                                                      |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  A  +  M  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  M  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  A  +  +  A  +  M  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  A  +  +  A  +  +  +  +  +  +  +  +  A  +  +  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                                                          |             
      Granuloma, Multifocal                |                                                                          |             
      Hematopoietic Cell Proliferation,    |                                                                          |             
           Multifocal                      |                                              1     1  1     1     3  1   |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      | 1                       2           1        2                           |             
      Necrosis, Acute, Multifocal          |                      3                                                   |             
      Bile Duct, Hyperplasia, Multifocal   |                                                                   2      |             
      Centrilobular, Fatty Change, Diffuse |                                                                          |             
      Centrilobular, Necrosis, Acute,      |                                                                          |             
          Diffuse                          |                                                                          |             
      Right Lateral Lobe,                  |                                                                          |             
          Hepatodiaphragmatic Nodule       |                                                             1            |             
      Vein, Thrombosis                     |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                              +              +            |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |                                                             2            |             
      Inflammation, Suppurative            |                                              4                           |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess, Multiple                    |                                              4                           |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |                                                       1     2            |             
      Acinus, Atrophy, Diffuse             |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |                                                                          |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |          1        2     2  1  1           2     1     1     1  1        2|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                +         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  14                                                               
NTP Experiment-Test: 05072-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:26:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 2| 7| 4| 7| 7| 7|             
                             DAY ON TEST   | 2| 3| 2| 2| 8| 2| 2| 2| 2| 1| 2| 0| 2| 2| 0| 8| 1| 2| 3| 6| 3| 4| 0| 3| 3|             
                                           | 9| 5| 9| 9| 6| 9| 9| 1| 9| 4| 9| 3| 9| 9| 3| 1| 2| 9| 0| 1| 0| 6| 5| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    2 PPM                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Developmental Malformation           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pigmentation                         |                                                    2                     |             
      Artery, Mineralization, Multifocal   |    4                                                                     |             
      Atrium Left, Thrombosis              |                                                                          |             
      Epicardium, Inflammation, Chronic,   |                                                                          |             
           Focal                           |                                                                          |             
      Epicardium, Inflammation, Chronic    |                                                                          |             
          Active, Focal                    |                                                                          |             
      Epicardium, Inflammation, Suppurative|                                              2                           |             
      Valve, Pigmentation                  |                                                       2                  |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Capsule, Accessory Adrenal Cortical  |                                                                          |             
          Nodule                           |                                                                          |             
      Capsule, Inflammation, Chronic       |                                                                          |             
          Active, Suppurative              |                                              4                           |             
      Subcapsular, Hyperplasia, Diffuse    |                                        3              4                  |             
      Subcapsular, Hyperplasia, Focal      |                            2                                             |             
      Subcapsular, Hyperplasia, Multifocal | 3  2  3  2  2  3  2  2  3     2  3  2     2  3     3     2  3  2  2  2  3|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage, Acute                    |                                                                          |             
      Hyperplasia, Focal                   |                                                          2               |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                     4                                    |             
      Hyperplasia, Multifocal              |          2                 2                                             |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +|             
      Congestion                           |             3                                                            |             
      Cyst                                 |                                                                          |             
      Pars Distalis, Angiectasis           |                                     3              3                     |             
      Pars Distalis, Hyperplasia, Focal    |                                        2     1                          2|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                    3                     |             
      Inflammation, Chronic, Focal         |                                                                          |             
      Inflammation, Chronic, Multifocal    |                   2                                                      |             
      Inflammation, Chronic Active, Focal  |                                                    2                     |             
      Follicle, Cyst, Multiple             |             1                                                            |             
      Follicular Cell, Hyperplasia, Focal  |                               2                    2                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  15                                                               
NTP Experiment-Test: 05072-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:26:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 2| 7| 4| 7| 7| 7|             
                             DAY ON TEST   | 2| 3| 2| 2| 8| 2| 2| 2| 2| 1| 2| 0| 2| 2| 0| 8| 1| 2| 3| 6| 3| 4| 0| 3| 3|             
                                           | 9| 5| 9| 9| 6| 9| 9| 1| 9| 4| 9| 3| 9| 9| 3| 1| 2| 9| 0| 1| 0| 6| 5| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    2 PPM                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Follicular Cell, Hyperplasia,        |                                                                          |             
          Multifocal                       |          2        3                                                      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                +         |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |                                                                          |             
      Cyst                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                                          |             
      Angiectasis, Focal                   |                                                                          |             
      Cyst                                 | 2           3                                      2              2      |             
      Metaplasia, Focal, Osseous           |                                                                          |             
      Pigmentation                         |                                                                          |             
      Periovarian Tissue, Infiltration     |                                                                          |             
          Cellular, Lymphocyte             |                            3                                             |             
      Periovarian Tissue, Inflammation,    |                                                                          |             
           Chronic Active                  |                                              3                           |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                                          |             
      Abscess, Multiple                    |                                              4                           |             
      Cyst                                 |    2                                      3                              |             
      Dilatation                           |                         4                                                |             
      Hyperplasia, Cystic                  |                         3                                                |             
      Inflammation, Chronic Active         |                                                                          |             
      Thrombosis, Multiple                 |                                                                          |             
      Bilateral, Hyperplasia, Cystic       | 3     2  3  1  3  2           3  1     3           1  3     4  1  1  3  4|             
      Epithelium, Hyperplasia, Focal       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy, Focal                       |       3                                                                  |             
      Myeloid Cell, Hyperplasia            |          2                                      4                        |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage, Acute                    |                      3                                                   |             
      Lumbar, Hyperplasia, Lymphoid        |                                                                          |             
      Mediastinal, Hyperplasia, Lymphoid   |                   3        2                                         2   |             
      Mediastinal, Hyperplasia             |                                                                          |             
      Pancreatic, Hemorrhage, Acute        |                      3                                                   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  M  +  +  +  +  +|             
      Hemorrhage, Subacute                 |       2                                                                  |             
      Hyperplasia, Lymphoid                |          2                 2     3           3                 2     2  4|             
      Hyperplasia                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  16                                                               
NTP Experiment-Test: 05072-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:26:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 2| 7| 4| 7| 7| 7|             
                             DAY ON TEST   | 2| 3| 2| 2| 8| 2| 2| 2| 2| 1| 2| 0| 2| 2| 0| 8| 1| 2| 3| 6| 3| 4| 0| 3| 3|             
                                           | 9| 5| 9| 9| 6| 9| 9| 1| 9| 4| 9| 3| 9| 9| 3| 1| 2| 9| 0| 1| 0| 6| 5| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    2 PPM                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hyperplasia, Re Cell                 |                                                                          |             
      Infiltration Cellular, Histiocyte    |    3                                                                     |             
      Inflammation, Subacute               |                      2                                                   |             
      Pigmentation, Hemosiderin            |    2                                                                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | M  +  +  +  +  +  +  +  +  M  +  M  +  +  M  +  M  +  +  M  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |          2              3                                                |             
      Hemorrhage, Acute                    |    3     2        2  3  3                                                |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia, Focal                       |                      4                                                   |             
      Hematopoietic Cell Proliferation     | 3        2                 3                 3     3                 2   |             
      Hyperplasia, Lymphoid                |                                                             2        2  2|             
      Capsule, Inflammation, Chronic Active|                                              3                           |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  M  +  +  +  M  +  +  M  +  M  +  +  +  +     +  M  M  +  +|             
      Depletion Lymphoid                   |                                  3           4  3                        |             
      Ectopic Parathyroid Gland            |                                                                          |             
      Hyperplasia, Lymphoid                |                                                    1        1            |             
      Metaplasia, Focal, Osseous           |                   3                                                      |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  M  +  +  +  +  +  +     +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Ectasia, Multifocal                  |                                                                          |             
      Hyperplasia, Diffuse                 |          4                 2        4        2     3                     |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic Active                  |                                     4                                    |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |                2                       2              X     1           2|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                 4                        |             
      Compression                          |          X        X        X                                             |             
      Hydrocephalus                        |                                                                          |             
      Mineralization, Multifocal           | 2                       2        1     2           1        3  2  1  2  1|             
      Meninges, Infiltration Cellular,     |                                                                          |             
           Multifocal, Lymphocyte          |                                                                          |             
      Perivascular, Infiltration Cellular, |                                                                          |             
           Multifocal, Lymphocyte          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Exudate                              |                            2                                             |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  17                                                               
NTP Experiment-Test: 05072-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:26:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 2| 7| 4| 7| 7| 7|             
                             DAY ON TEST   | 2| 3| 2| 2| 8| 2| 2| 2| 2| 1| 2| 0| 2| 2| 0| 8| 1| 2| 3| 6| 3| 4| 0| 3| 3|             
                                           | 9| 5| 9| 9| 6| 9| 9| 1| 9| 4| 9| 3| 9| 9| 3| 1| 2| 9| 0| 1| 0| 6| 5| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    2 PPM                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |                                                                          |             
      Mineralization                       |    2                                                                     |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Embolus Tumor, Multiple              |                                                                X         |             
      Hemorrhage, Acute, Focal             |                      3                                                   |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |                            2  2                                          |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Multifocal                      | 3     2  4  4  2  2        4  2  4  4  4           4  3        2  2     2|             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Multifocal, Histiocyte          | 3     4  4  4     3     2  4  4  4        3        3  2                  |             
      Bronchiole, Hyperplasia, Multifocal  | 3     2  4  4  2  2     3  4  2  4  4  4     2     4  3  1     2  2     2|             
      Mediastinum, Infiltration Cellular,  |                                                                          |             
           Multifocal, Lymphocyte          |                                  3                                       |             
      Mediastinum, Inflammation, Chronic   |                                                                   3      |             
      Pleura, Hyperplasia                  |                                                                   3      |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lumen, Exudate                       |       1  3  1  1  2     1  2     2     1  2        2        2  3     1  2|             
      Mucosa, Inflammation, Chronic Active | 2                          2  2  1  4     1     4  1        2        1  1|             
      Olfactory Epithelium, Atrophy        |                            2                    3                        |             
      Respiratory Epithelium, Hyperplasia  | 1                          2  1     2     1     3  1           2        2|             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        | 1                             2     3              1                     |             
      Sinus, Hyperplasia                   |                                                 3                        |             
      Sinus, Inflammation, Chronic Active  |                                                 4                        |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                      +                                                   |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |          1        1        2  2              1  1  1  2     1            |             
      Metaplasia, Focal, Osseous           |                                  3                                       |             
      Pigmentation, Diffuse                |                                                                          |             
      Cortex, Mineralization, Multifocal   |    3                                                                     |             
      Interstitial Tissue, Inflammation,   |                                                                          |             
           Chronic, Multifocal             |                                                                          |             
      Renal Tubule, Hyperplasia, Focal     |                                  2                                       |             
      Renal Tubule, Necrosis, Acute,       |                                                                          |             
          Multifocal                       |    2                                                                     |             
                                            __________________________________________________________________________|             
   Ureter                                  |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  18                                                               
NTP Experiment-Test: 05072-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:26:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 2| 7| 4| 7| 7| 7|             
                             DAY ON TEST   | 2| 3| 2| 2| 8| 2| 2| 2| 2| 1| 2| 0| 2| 2| 0| 8| 1| 2| 3| 6| 3| 4| 0| 3| 3|             
                                           | 9| 5| 9| 9| 6| 9| 9| 1| 9| 4| 9| 3| 9| 9| 3| 1| 2| 9| 0| 1| 0| 6| 5| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    2 PPM                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |                                                                          |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |                1  1                       2     1  1        1            |             
      Artery, Inflammation, Chronic Active,|                                                                          |             
           Multifocal                      |                                                                         4|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  19                                                               
NTP Experiment-Test: 05072-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:26:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 6| 7| 4| 7| 6| 7| 6| 7| 6| 6| 7| 7| 6| 7| 7| 5| 6| 6| 7| 6| 7| 5| 7|            |
                             DAY ON TEST   | 3| 2| 9| 3| 4| 2| 4| 3| 6| 3| 9| 7| 3| 3| 8| 3| 3| 6| 3| 8| 3| 7| 3| 4| 0|            |
                                           | 0| 0| 8| 0| 4| 6| 5| 0| 6| 0| 8| 4| 0| 0| 4| 0| 0| 5| 3| 7| 0| 3| 0| 6| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    2 PPM                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  A  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  A  +|  36        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  A  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
      Peyer's Patch, Hyperplasia, Lymphoid |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|  44        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|  44        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     |                                     X                                    |      1     |
      Granuloma, Multifocal                |          4                                                               |      1  4.0|
      Hematopoietic Cell Proliferation,    |                                                                          |            |
           Multifocal                      |                                                 1                        |      7  1.3|
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |                            1                       2                     |      6  1.5|
      Necrosis, Acute, Multifocal          | 2                                                        2               |      3  2.3|
      Bile Duct, Hyperplasia, Multifocal   |                                                                          |      1  2.0|
      Centrilobular, Fatty Change, Diffuse |                               3                                          |      1  3.0|
      Centrilobular, Necrosis, Acute,      |                                                                          |            |
          Diffuse                          |                               2                                          |      1  2.0|
      Right Lateral Lobe,                  |                                                                          |            |
          Hepatodiaphragmatic Nodule       |                                                                          |      1  1.0|
      Vein, Thrombosis                     |                                                    3                     |      1  3.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |             +                             +                 +            |   5        |
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |                                                                          |      1  2.0|
      Inflammation, Suppurative            |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Abscess, Multiple                    |                                                                          |      1  4.0|
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      | 1     1                                      1           2  1            |      7  1.3|
      Acinus, Atrophy, Diffuse             |                                                       1                  |      1  1.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infiltration Cellular, Focal,        |                                                                          |            |
          Lymphocyte                       |                                                       2                  |      1  2.0|
      Infiltration Cellular, Multifocal,   |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  20                                                               
NTP Experiment-Test: 05072-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:26:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 6| 7| 4| 7| 6| 7| 6| 7| 6| 6| 7| 7| 6| 7| 7| 5| 6| 6| 7| 6| 7| 5| 7|            |
                             DAY ON TEST   | 3| 2| 9| 3| 4| 2| 4| 3| 6| 3| 9| 7| 3| 3| 8| 3| 3| 6| 3| 8| 3| 7| 3| 4| 0|            |
                                           | 0| 0| 8| 0| 4| 6| 5| 0| 6| 0| 8| 4| 0| 0| 4| 0| 0| 5| 3| 7| 0| 3| 0| 6| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    2 PPM                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
           Lymphocyte                      |       3           1     1        2  1     2     1                    2   |     19  1.5|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                          +               |   2        |
      Developmental Malformation           |                                                          3               |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pigmentation                         |                                                                          |      1  2.0|
      Artery, Mineralization, Multifocal   |                                                                          |      1  4.0|
      Atrium Left, Thrombosis              |                                                       4                  |      1  4.0|
      Epicardium, Inflammation, Chronic,   |                                                                          |            |
           Focal                           |                   2                                                      |      1  2.0|
      Epicardium, Inflammation, Chronic    |                                                                          |            |
          Active, Focal                    |                            4                                             |      1  4.0|
      Epicardium, Inflammation, Suppurative|                                                                          |      1  2.0|
      Valve, Pigmentation                  |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Capsule, Accessory Adrenal Cortical  |                                                                          |            |
          Nodule                           |                                     X                                    |      1     |
      Capsule, Inflammation, Chronic       |                                                                          |            |
          Active, Suppurative              |                                                                          |      1  4.0|
      Subcapsular, Hyperplasia, Diffuse    |                               2                 4                        |      4  3.3|
      Subcapsular, Hyperplasia, Focal      |                                                                          |      1  2.0|
      Subcapsular, Hyperplasia, Multifocal | 3     2  2  2  2  3  2  3  2     2  3  2  1  2     2  2  2  3  2  3  3  2|     43  2.3|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage, Acute                    |    3                                                                     |      1  3.0|
      Hyperplasia, Focal                   |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  M  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Hyperplasia, Focal                   |       3                                                        2         |      2  2.5|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia, Focal                   |                                           2     3                        |      3  3.0|
      Hyperplasia, Multifocal              |                                                          2               |      3  2.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +     +  M  +  M  +  M  +  +  +  +  M  +  M  +  +  M  +  +  +  +  +  +  +|  40        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Congestion                           |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  21                                                               
NTP Experiment-Test: 05072-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:26:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 6| 7| 4| 7| 6| 7| 6| 7| 6| 6| 7| 7| 6| 7| 7| 5| 6| 6| 7| 6| 7| 5| 7|            |
                             DAY ON TEST   | 3| 2| 9| 3| 4| 2| 4| 3| 6| 3| 9| 7| 3| 3| 8| 3| 3| 6| 3| 8| 3| 7| 3| 4| 0|            |
                                           | 0| 0| 8| 0| 4| 6| 5| 0| 6| 0| 8| 4| 0| 0| 4| 0| 0| 5| 3| 7| 0| 3| 0| 6| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    2 PPM                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Cyst                                 |                                        4                                 |      1  4.0|
      Pars Distalis, Angiectasis           |                         2                                                |      3  2.7|
      Pars Distalis, Hyperplasia, Focal    |                   2                                                      |      4  1.8|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                                                          |      1  3.0|
      Inflammation, Chronic, Focal         | 1           1                                                            |      2  1.0|
      Inflammation, Chronic, Multifocal    |       2                                                                  |      2  2.0|
      Inflammation, Chronic Active, Focal  |                                                                          |      1  2.0|
      Follicle, Cyst, Multiple             |                   1                                   1                  |      3  1.0|
      Follicular Cell, Hyperplasia, Focal  |                                                                          |      2  2.0|
      Follicular Cell, Hyperplasia,        |                                                                          |            |
          Multifocal                       |                      3                 2                          1      |      5  2.2|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |    +                                                                     |   2        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |                                                          +               |   1        |
      Cyst                                 |                                                          4               |      1  4.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Abscess                              |                                                 4                        |      1  4.0|
      Angiectasis, Focal                   |                                                                         4|      1  4.0|
      Cyst                                 |       3           4              4           4                          4|      9  3.1|
      Metaplasia, Focal, Osseous           |          2                                                               |      1  2.0|
      Pigmentation                         |                               2                                          |      1  2.0|
      Periovarian Tissue, Infiltration     |                                                                          |            |
          Cellular, Lymphocyte             |                      3                                                   |      2  3.0|
      Periovarian Tissue, Inflammation,    |                                                                          |            |
           Chronic Active                  |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Abscess                              |                                                 4                        |      1  4.0|
      Abscess, Multiple                    |                                                                          |      1  4.0|
      Cyst                                 |                               3                                          |      3  2.7|
      Dilatation                           |                                                                          |      1  4.0|
      Hyperplasia, Cystic                  |                               2        4                                 |      3  3.0|
      Inflammation, Chronic Active         |                                                 2                        |      1  2.0|
      Thrombosis, Multiple                 |          3                                                               |      1  3.0|
      Bilateral, Hyperplasia, Cystic       | 1     1  4  2  1  1  2  1  4        2        2     2  1  2  3  2  2  2  2|     35  2.1|
      Epithelium, Hyperplasia, Focal       |                                                 2                        |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  22                                                               
NTP Experiment-Test: 05072-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:26:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 6| 7| 4| 7| 6| 7| 6| 7| 6| 6| 7| 7| 6| 7| 7| 5| 6| 6| 7| 6| 7| 5| 7|            |
                             DAY ON TEST   | 3| 2| 9| 3| 4| 2| 4| 3| 6| 3| 9| 7| 3| 3| 8| 3| 3| 6| 3| 8| 3| 7| 3| 4| 0|            |
                                           | 0| 0| 8| 0| 4| 6| 5| 0| 6| 0| 8| 4| 0| 0| 4| 0| 0| 5| 3| 7| 0| 3| 0| 6| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    2 PPM                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy, Focal                       |                                                                          |      1  3.0|
      Myeloid Cell, Hyperplasia            |                                                 3                        |      3  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage, Acute                    |                                                                          |      1  3.0|
      Lumbar, Hyperplasia, Lymphoid        |                                                 2                        |      1  2.0|
      Mediastinal, Hyperplasia, Lymphoid   |                         3                                                |      4  2.5|
      Mediastinal, Hyperplasia             |                                                                2         |      1  2.0|
      Pancreatic, Hemorrhage, Acute        |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
      Hemorrhage, Subacute                 |                                                                          |      1  2.0|
      Hyperplasia, Lymphoid                |                                                                          |      7  2.6|
      Hyperplasia                          |                                        2                                 |      1  2.0|
      Hyperplasia, Re Cell                 |                                                    2                     |      1  2.0|
      Infiltration Cellular, Histiocyte    |                                                                          |      1  3.0|
      Inflammation, Subacute               |                                                                          |      1  2.0|
      Pigmentation, Hemosiderin            |    2                                                                     |      2  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +     +  +  +  M  +  +  +  +  M  M  +  +  +  +  +  +  +  M  +  M  +  +  M|  37        |
      Hematopoietic Cell Proliferation     | 3                                         3     3                        |      5  2.8|
      Hemorrhage, Acute                    |          2                             1        2     2                  |      9  2.2|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ectasia, Focal                       |                                                                          |      1  4.0|
      Hematopoietic Cell Proliferation     |          2     2              4  4           2  3              3  2      |     14  2.7|
      Hyperplasia, Lymphoid                |                                                                      4  2|      5  2.4|
      Capsule, Inflammation, Chronic Active|                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  M  +  M  +  +  M  +  +  M  +  +  +  +  M  +  M  M  M  A  M  M  +  +  +|  32        |
      Depletion Lymphoid                   |                4              3                                         3|      6  3.3|
      Ectopic Parathyroid Gland            |                X                 X                                       |      2     |
      Hyperplasia, Lymphoid                |       2                                2                                 |      4  1.5|
      Metaplasia, Focal, Osseous           |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +|  45        |
      Ectasia, Multifocal                  |       3                                2                                 |      2  2.5|
      Hyperplasia, Diffuse                 |       1                                                                  |      6  2.7|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  23                                                               
NTP Experiment-Test: 05072-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:26:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 6| 7| 4| 7| 6| 7| 6| 7| 6| 6| 7| 7| 6| 7| 7| 5| 6| 6| 7| 6| 7| 5| 7|            |
                             DAY ON TEST   | 3| 2| 9| 3| 4| 2| 4| 3| 6| 3| 9| 7| 3| 3| 8| 3| 3| 6| 3| 8| 3| 7| 3| 4| 0|            |
                                           | 0| 0| 8| 0| 4| 6| 5| 0| 6| 0| 8| 4| 0| 0| 4| 0| 0| 5| 3| 7| 0| 3| 0| 6| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    2 PPM                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
           Chronic Active                  |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrous Osteodystrophy               |       1              1                          1                 1     2|     10  1.4|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Abscess                              |                                                                          |      1  4.0|
      Compression                          |       X                          X     X  X  X                           |      8     |
      Hydrocephalus                        |                                  2                                       |      1  2.0|
      Mineralization, Multifocal           | 1     1        2     3  1  1  3                 1     1                 1|     20  1.6|
      Meninges, Infiltration Cellular,     |                                                                          |            |
           Multifocal, Lymphocyte          |          1                                                               |      1  1.0|
      Perivascular, Infiltration Cellular, |                                                                          |            |
           Multifocal, Lymphocyte          |       2              2                                            3      |      3  2.3|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +     +  +  +  +  +  +  +  +  +     +  +  +  +  +  M  +  +  +  +  +  +  +|  47        |
      Exudate                              |                                                                          |      1  2.0|
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |          2                                                               |      1  2.0|
      Mineralization                       |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Embolus Tumor, Multiple              |                                                                          |      1     |
      Hemorrhage, Acute, Focal             |                                                                          |      1  3.0|
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |                                                                          |      2  2.0|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Multifocal                      | 4  2  3  4  1  4  3  4  4  2  3  2  2  3  4  3  3  4  3  3  4  2  3  2  4|     41  3.0|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Multifocal, Histiocyte          | 2     2  4     3  3  4  4  3  3  2  3  3     3  2     2  2  4  4  3     3|     32  3.1|
      Bronchiole, Hyperplasia, Multifocal  | 4  2  3  4  1  4     4  4     3  2  2  3  4  3  3  4  3  3  4     3  2  4|     41  3.0|
      Mediastinum, Infiltration Cellular,  |                                                                          |            |
           Multifocal, Lymphocyte          |          2                                                               |      2  2.5|
      Mediastinum, Inflammation, Chronic   |                                                                          |      1  3.0|
      Pleura, Hyperplasia                  |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lumen, Exudate                       | 1  2  1                 1  1  3  1  2  1  3  1  1  2  2  2        2  3  2|     33  1.7|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  24                                                               
NTP Experiment-Test: 05072-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:26:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 6| 7| 4| 7| 6| 7| 6| 7| 6| 6| 7| 7| 6| 7| 7| 5| 6| 6| 7| 6| 7| 5| 7|            |
                             DAY ON TEST   | 3| 2| 9| 3| 4| 2| 4| 3| 6| 3| 9| 7| 3| 3| 8| 3| 3| 6| 3| 8| 3| 7| 3| 4| 0|            |
                                           | 0| 0| 8| 0| 4| 6| 5| 0| 6| 0| 8| 4| 0| 0| 4| 0| 0| 5| 3| 7| 0| 3| 0| 6| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    2 PPM                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Mucosa, Inflammation, Chronic Active |          2  1     4     2        1  1  4  2        2     2  1  1         |     23  1.9|
      Olfactory Epithelium, Atrophy        |                                                                          |      2  2.5|
      Respiratory Epithelium, Hyperplasia  |             1     3                    2     1     1     1  1  2         |     17  1.6|
      Respiratory Epithelium, Metaplasia,  |                                                                          |            |
           Squamous                        |                   3                    2  1                    2         |      8  1.9|
      Sinus, Hyperplasia                   |                                                                          |      1  3.0|
      Sinus, Inflammation, Chronic Active  |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infiltration Cellular, Lymphocyte    |       2           1     1     1              2                    2      |     15  1.4|
      Metaplasia, Focal, Osseous           |                                                                          |      1  3.0|
      Pigmentation, Diffuse                |                               3                                          |      1  3.0|
      Cortex, Mineralization, Multifocal   |                                                                          |      1  3.0|
      Interstitial Tissue, Inflammation,   |                                                                          |            |
           Chronic, Multifocal             |             1                    2                                       |      2  1.5|
      Renal Tubule, Hyperplasia, Focal     |                                                                          |      1  2.0|
      Renal Tubule, Necrosis, Acute,       |                                                                          |            |
          Multifocal                       |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Ureter                                  |             +                                                            |   1        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Infiltration Cellular, Focal,        |                                                                          |            |
          Lymphocyte                       |                                     2                                    |      1  2.0|
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |          3           1  1     1  2        1  3           2  1     2  2   |     17  1.5|
      Artery, Inflammation, Chronic Active,|                                                                          |            |
           Multifocal                      |                                                                          |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  25                                                               
NTP Experiment-Test: 05072-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:26:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 7| 1| 3| 6| 6| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 0| 1| 2| 3| 6| 9| 0| 3| 3| 3| 3| 6| 0| 3| 0| 3| 1| 7| 3| 3| 3| 3|             
                                           | 0| 0| 0| 1| 6| 8| 5| 6| 3| 3| 0| 0| 0| 0| 5| 1| 1| 6| 1| 8| 6| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    0.5 PPM                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +     +  A  +  M  A  +  +  +  +  +  A  +  +  +  +  +  +  +  M  +  +|             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  A  M  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Peyer's Patch, Hyperplasia, Lymphoid |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  M  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |                                  2                                       |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  A  +  M  A  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  M  +  M  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  A  +  +  A  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cytomegaly                           |                                                                          |             
      Fatty Change, Focal                  |             3                                                            |             
      Hematopoietic Cell Proliferation,    |                                                                          |             
           Multifocal                      | 1                                1                                1  1   |             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |                                                                         2|             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |             1                                                  1         |             
      Inflammation, Acute, Multifocal      |                                                                          |             
      Inflammation, Multifocal, Subacute   |                                                       1                 1|             
      Necrosis, Acute, Multifocal          |                                                                          |             
      Necrosis, Chronic, Multifocal        |                                                                          |             
      Necrosis, Focal, Subacute            |                                              2                           |             
      Vacuolization Cytoplasmic, Multifocal|                            2                                             |             
      Periportal, Vacuolization            |                                                                          |             
          Cytoplasmic, Diffuse             |                                                                          |             
      Portal, Inflammation, Chronic,       |                                                                          |             
          Multifocal                       |                               1                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                      +                                                   |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 | 4                                                                        |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |    1                          2                 2        1               |             
      Acinus, Atrophy, Diffuse             | 4                                                                        |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |                                                                          |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  26                                                               
NTP Experiment-Test: 05072-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:26:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 7| 1| 3| 6| 6| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 0| 1| 2| 3| 6| 9| 0| 3| 3| 3| 3| 6| 0| 3| 0| 3| 1| 7| 3| 3| 3| 3|             
                                           | 0| 0| 0| 1| 6| 8| 5| 6| 3| 3| 0| 0| 0| 0| 5| 1| 1| 6| 1| 8| 6| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    0.5 PPM                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
           Lymphocyte                      |    2  1                       1     1        1  1     2        1     2  1|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                                          |             
      Epithelium, Hyperplasia, Diffuse     |                                                             2            |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |                                                    2                     |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      | 1                                                                        |             
      Necrosis, Acute, Multifocal          |                                                                          |             
      Mucosa, Degeneration, Multifocal     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                 +                        |             
      Aorta, Inflammation, Chronic Active, |                                                                          |             
           Focal                           |                                                 3                        |             
      Artery, Inflammation, Chronic,       |                                                                          |             
          Multifocal                       |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |                         1                                                |             
      Inflammation, Chronic, Multifocal    |                                                                          |             
      Mineralization, Multifocal           |                                                                          |             
      Necrosis, Acute, Focal               |                                                                          |             
      Atrium Left, Thrombosis              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Capsule, Accessory Adrenal Cortical  |                                                                          |             
          Nodule                           |                                                                          |             
      Subcapsular, Hyperplasia, Diffuse    |                                                       3              2   |             
      Subcapsular, Hyperplasia, Multifocal | 2  2  2  2  2     1  2  2  2  3  2  3  2  2  3  3        3  2  2  2     3|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hyperplasia, Focal                   |                                                                   4      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                      3  4              2                                 |             
      Hyperplasia, Multifocal              |                                                                          |             
      Hypoplasia                           |             4                                                            |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  M  +  +  +  +  +  +  +  M  +  M  +  +  M  +  +  +  +  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                                                 2  3                 2  4|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  27                                                               
NTP Experiment-Test: 05072-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:26:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 7| 1| 3| 6| 6| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 0| 1| 2| 3| 6| 9| 0| 3| 3| 3| 3| 6| 0| 3| 0| 3| 1| 7| 3| 3| 3| 3|             
                                           | 0| 0| 0| 1| 6| 8| 5| 6| 3| 3| 0| 0| 0| 0| 5| 1| 1| 6| 1| 8| 6| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    0.5 PPM                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pars Distalis, Hyperplasia, Focal    |                               1                                   2      |             
      Pars Distalis, Hyperplasia,          |                                                                          |             
          Multifocal                       |                                                 2                        |             
      Pars Distalis, Hypertrophy, Focal    |             2                                                            |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |                                                       1                  |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |                                                                          |             
      Inflammation, Acute, Focal           |                                                                         2|             
      Inflammation, Chronic, Focal         |                                              1                           |             
      Inflammation, Chronic, Multifocal    |                                                                          |             
      Inflammation, Chronic Active, Focal  |                               1                                          |             
      Inflammation, Chronic Active,        |                                                                          |             
          Multifocal                       |                                     1                       2            |             
      Follicle, Cyst                       |                                                                          |             
      Follicle, Cyst, Multiple             |                                                                          |             
      Follicular Cell, Hyperplasia, Focal  |                                                    3                     |             
      Follicular Cell, Hyperplasia,        |                                                                          |             
          Multifocal                       |       1                          2     3        4                        |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |                                                                          |             
      Cyst, Multiple                       |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Cyst                                 | 2                    3  4                                            2   |             
      Mineralization                       |                         3                                                |             
      Pigmentation                         |                         4                                                |             
      Periovarian Tissue, Infiltration     |                                                                          |             
          Cellular, Lymphocyte             |                         4                                                |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |          3                                                               |             
      Dilatation                           |                                              4  4                        |             
      Hyperplasia, Atypical, Focal,        |                                                                          |             
          Glandular                        |             3                                                            |             
      Hyperplasia, Cystic                  | 3                                               3                        |             
      Bilateral, Hyperplasia, Cystic       |    2  2     3     2  2  2  4  3  2  3  2     2     1  4  1  2  3  4  1  3|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  28                                                               
NTP Experiment-Test: 05072-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:26:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 7| 1| 3| 6| 6| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 0| 1| 2| 3| 6| 9| 0| 3| 3| 3| 3| 6| 0| 3| 0| 3| 1| 7| 3| 3| 3| 3|             
                                           | 0| 0| 0| 1| 6| 8| 5| 6| 3| 3| 0| 0| 0| 0| 5| 1| 1| 6| 1| 8| 6| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    0.5 PPM                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Atrophy, Diffuse                     |                                                                3         |             
      Myeloid Cell, Hyperplasia            |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inguinal, Hyperplasia, Lymphoid      |                                                             2     2      |             
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |             
      Mediastinal, Hyperplasia             |                                                                      4   |             
      Renal, Hematopoietic Cell            |                                                                          |             
          Proliferation                    |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  M  +  +|             
      Cyst                                 |                                                    2        3            |             
      Hemorrhage, Acute                    |                         2                                                |             
      Hyperplasia, Lymphoid                |                               2     1                       2            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | M  +  +  +  M  M  M  M  +  M  +  +  +  M  M  +  +  M  +  M  +  +  +  +  +|             
      Depletion Lymphoid                   |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                   2      |             
      Hemorrhage, Acute                    |                         3                                         2      |             
      Hemorrhage, Subacute                 |                                                                          |             
      Hyperplasia, Lymphoid                |                                  3           2                           |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     | 3                                         4     2        3     2  2      |             
      Hyperplasia, Lymphoid                |             2                                2        3                  |             
      Pigmentation, Hemosiderin            |                                                                          |             
      Capsule, Ectopic Tissue              |                                        X                                 |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  M  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Depletion Lymphoid                   |                   3        3                                             |             
      Ectopic Parathyroid Gland            |                                           X                              |             
      Hyperplasia, Lymphoid                |                                  2           2        2           2      |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  M  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia, Multifocal                  |                                                                      2   |             
      Hyperplasia, Diffuse                 |                                                    2                     |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hair Follicle, Inflammation, Chronic |                                                                          |             
          Active                           |                                                                          |             
      Subcutaneous Tissue, Edema           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |    2                          2                                      1  2|             
      Osteoporosis, Focal                  |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                      +                                                   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  29                                                               
NTP Experiment-Test: 05072-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:26:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 7| 1| 3| 6| 6| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 0| 1| 2| 3| 6| 9| 0| 3| 3| 3| 3| 6| 0| 3| 0| 3| 1| 7| 3| 3| 3| 3|             
                                           | 0| 0| 0| 1| 6| 8| 5| 6| 3| 3| 0| 0| 0| 0| 5| 1| 1| 6| 1| 8| 6| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    0.5 PPM                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                                                                          |             
      Mineralization, Multifocal           |    2  2  2  2        1     1              1  1  2              3        2|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage, Acute, Multifocal        |                                                                          |             
      Hemorrhage, Multifocal, Subacute     |                                           4                              |             
      Infiltration Cellular, Diffuse,      |                                                                          |             
          Lymphocyte                       |                                                                          |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |                                                    1                     |             
      Inflammation, Acute, Focal           |                                        2                                 |             
      Pigmentation, Diffuse, Hemosiderin   |                                                                   3      |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           | 2                    2                          4              3  1  2   |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Multifocal                      |                                                       4                 1|             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Diffuse, Histiocyte             |                                                                   2      |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Multifocal, Histiocyte          |                         2              4  2                              |             
      Bronchiole, Hyperplasia, Focal       |                                                                          |             
      Bronchiole, Hyperplasia, Multifocal  |                                                             1           1|             
      Interstitium, Inflammation, Chronic  |                                                                          |             
          Active, Focal                    |                                                                          |             
      Pleura, Infiltration Cellular,       |                                                                          |             
          Lymphocyte                       |                                  3                                       |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lumen, Exudate                       |                         3  2  1  3  2  1  1     2     1  1     1  2  2   |             
      Lumen, Foreign Body                  |                                                                          |             
      Mucosa, Inflammation, Chronic        | 2                                                                        |             
      Mucosa, Inflammation, Chronic Active |                         1                                                |             
      Mucosa, Ulcer                        |                                                                          |             
      Nasolacrimal Duct, Exudate           |                                                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Chronic                         |                                                                      2   |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Chronic Active                  |                                                             2            |             
      Olfactory Epithelium, Atrophy        |                                                 1                    1   |             
      Respiratory Epithelium, Hyperplasia  |                      1                                                   |             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  30                                                               
NTP Experiment-Test: 05072-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:26:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 7| 1| 3| 6| 6| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 0| 1| 2| 3| 6| 9| 0| 3| 3| 3| 3| 6| 0| 3| 0| 3| 1| 7| 3| 3| 3| 3|             
                                           | 0| 0| 0| 1| 6| 8| 5| 6| 3| 3| 0| 0| 0| 0| 5| 1| 1| 6| 1| 8| 6| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    0.5 PPM                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                | 2                 1                                                      |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                             +     +      |             
      Abscess                              |                                                                   4      |             
      Atrophy                              |                                                                   4      |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                   +      |             
      Inflammation, Chronic Active         |                                                                   4      |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infarct                              | 1                                                                        |             
      Infiltration Cellular, Lymphocyte    |                            2                                   1  1  1  1|             
      Nephropathy, Chronic                 |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      | 2  1        2           3              1              1              1  1|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  31                                                               
NTP Experiment-Test: 05072-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:26:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 3| 6| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 2|            |
                             DAY ON TEST   | 2| 3| 3| 3| 3| 9| 3| 3| 3| 9| 1| 8| 1| 9| 3| 3| 9| 3| 3| 3| 3| 3| 3| 0| 6|            |
                                           | 4| 1| 1| 1| 2| 9| 2| 1| 2| 2| 5| 9| 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 1| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    0.5 PPM                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|  49        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  M  +     M  +|  40        |
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |                                                    1                     |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  A  M  +  +  +  +  +  +  +  +  M  +  +  +  +|  44        |
      Peyer's Patch, Hyperplasia, Lymphoid |                                                       2                  |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  M  +|  43        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cytomegaly                           |                               3                                          |      1  3.0|
      Fatty Change, Focal                  |                                                                          |      1  3.0|
      Hematopoietic Cell Proliferation,    |                                                                          |            |
           Multifocal                      |                      1        1                    1  1     1     1      |     10  1.0|
      Infiltration Cellular, Focal,        |                                                                          |            |
          Lymphocyte                       |                                                                          |      1  2.0|
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |                                                                          |      2  1.0|
      Inflammation, Acute, Multifocal      |                                                             1            |      1  1.0|
      Inflammation, Multifocal, Subacute   |    1                                                                     |      3  1.0|
      Necrosis, Acute, Multifocal          | 4                             3                 2                       3|      4  3.0|
      Necrosis, Chronic, Multifocal        |                                  4                                       |      1  4.0|
      Necrosis, Focal, Subacute            |    1                                                                     |      2  1.5|
      Vacuolization Cytoplasmic, Multifocal|                                                                          |      1  2.0|
      Periportal, Vacuolization            |                                                                          |            |
          Cytoplasmic, Diffuse             |                            3                                             |      1  3.0|
      Portal, Inflammation, Chronic,       |                                                                          |            |
          Multifocal                       |       1                                                                  |      2  1.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                                                          |      1  4.0|
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |       2  1  2  2     1                                                   |      9  1.6|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  32                                                               
NTP Experiment-Test: 05072-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:26:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 3| 6| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 2|            |
                             DAY ON TEST   | 2| 3| 3| 3| 3| 9| 3| 3| 3| 9| 1| 8| 1| 9| 3| 3| 9| 3| 3| 3| 3| 3| 3| 0| 6|            |
                                           | 4| 1| 1| 1| 2| 9| 2| 1| 2| 2| 5| 9| 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 1| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    0.5 PPM                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Acinus, Atrophy, Diffuse             |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infiltration Cellular, Focal,        |                                                                          |            |
          Lymphocyte                       |             2                                                            |      1  2.0|
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |       2  2     2                          2           2        1     1   |     17  1.5|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Abscess                              |       1                                                                  |      1  1.0|
      Epithelium, Hyperplasia, Diffuse     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Infiltration Cellular, Focal,        |                                                                          |            |
          Lymphocyte                       |                                                                          |      1  2.0|
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |                                                                          |      1  1.0|
      Necrosis, Acute, Multifocal          |                                                                         3|      1  3.0|
      Mucosa, Degeneration, Multifocal     |                                                       2                  |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                         +                                                |   2        |
      Aorta, Inflammation, Chronic Active, |                                                                          |            |
           Focal                           |                                                                          |      1  3.0|
      Artery, Inflammation, Chronic,       |                                                                          |            |
          Multifocal                       |                         4                                                |      1  4.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |                                                                          |      1  1.0|
      Inflammation, Chronic, Multifocal    |                                                                         2|      1  2.0|
      Mineralization, Multifocal           |                                                                         2|      1  2.0|
      Necrosis, Acute, Focal               |                                                                         3|      1  3.0|
      Atrium Left, Thrombosis              |                                                          4               |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Capsule, Accessory Adrenal Cortical  |                                                                          |            |
          Nodule                           |                                              X           X               |      2     |
      Subcapsular, Hyperplasia, Diffuse    |    3                                         2                           |      4  2.5|
      Subcapsular, Hyperplasia, Multifocal |       2  3  3  2  1  3  4  2  3  3  2  2  2     2  3  2  2  3  2  3  3  1|     43  2.3|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  33                                                               
NTP Experiment-Test: 05072-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:26:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 3| 6| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 2|            |
                             DAY ON TEST   | 2| 3| 3| 3| 3| 9| 3| 3| 3| 9| 1| 8| 1| 9| 3| 3| 9| 3| 3| 3| 3| 3| 3| 0| 6|            |
                                           | 4| 1| 1| 1| 2| 9| 2| 1| 2| 2| 5| 9| 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 1| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    0.5 PPM                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Cyst                                 |                   3                                                      |      1  3.0|
      Hyperplasia, Focal                   |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | M  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Focal                   |                                                                          |      3  3.0|
      Hyperplasia, Multifocal              |                               2        2                                 |      2  2.0|
      Hypoplasia                           |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  M  +  +  +  +     +  M|  38        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Pars Distalis, Angiectasis           |                   4                    4                    4            |      7  3.3|
      Pars Distalis, Hyperplasia, Focal    |                               3                                   2      |      4  2.0|
      Pars Distalis, Hyperplasia,          |                                                                          |            |
          Multifocal                       |                                                    2                     |      2  2.0|
      Pars Distalis, Hypertrophy, Focal    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                   2                                               4      |      2  3.0|
      Infiltration Cellular, Focal,        |                                                                          |            |
          Lymphocyte                       |       2                                                                  |      2  1.5|
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |                                                                3         |      1  3.0|
      Inflammation, Acute, Focal           |                                                                          |      1  2.0|
      Inflammation, Chronic, Focal         |                                                                          |      1  1.0|
      Inflammation, Chronic, Multifocal    |                                              2              2            |      2  2.0|
      Inflammation, Chronic Active, Focal  |                                        1                                 |      2  1.0|
      Inflammation, Chronic Active,        |                                                                          |            |
          Multifocal                       |                                                                          |      2  1.5|
      Follicle, Cyst                       |    2                                                                     |      1  2.0|
      Follicle, Cyst, Multiple             |                               2        1                                 |      2  1.5|
      Follicular Cell, Hyperplasia, Focal  |                2                                                  3      |      3  2.7|
      Follicular Cell, Hyperplasia,        |                                                                          |            |
          Multifocal                       |                   2                    1     3              3  4         |      9  2.6|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +                                                                        |   1        |
      Cyst, Multiple                       | 4                                                                        |      1  4.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  34                                                               
NTP Experiment-Test: 05072-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:26:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 3| 6| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 2|            |
                             DAY ON TEST   | 2| 3| 3| 3| 3| 9| 3| 3| 3| 9| 1| 8| 1| 9| 3| 3| 9| 3| 3| 3| 3| 3| 3| 0| 6|            |
                                           | 4| 1| 1| 1| 2| 9| 2| 1| 2| 2| 5| 9| 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 1| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    0.5 PPM                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Cyst                                 |          4                    4           4                 4            |      8  3.4|
      Mineralization                       |                                                                          |      1  3.0|
      Pigmentation                         |                                                                          |      1  4.0|
      Periovarian Tissue, Infiltration     |                                                                          |            |
          Cellular, Lymphocyte             |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                                                          |      1  3.0|
      Dilatation                           |                                                                          |      2  4.0|
      Hyperplasia, Atypical, Focal,        |                                                                          |            |
          Glandular                        |                                                                          |      1  3.0|
      Hyperplasia, Cystic                  |                                                                3         |      3  3.0|
      Bilateral, Hyperplasia, Cystic       | 3  2  2  2  4  1  3  3  1  2        2  2  2  1  2  2  3  2        3  3   |     40  2.3|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy, Diffuse                     |                                                                          |      1  3.0|
      Myeloid Cell, Hyperplasia            |                            3                                             |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inguinal, Hyperplasia, Lymphoid      |                                           3                              |      3  2.3|
      Mediastinal, Hyperplasia, Lymphoid   |                                                                2         |      1  2.0|
      Mediastinal, Hyperplasia             |                                                                          |      1  4.0|
      Renal, Hematopoietic Cell            |                                                                          |            |
          Proliferation                    |                                                 4                        |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  M  +  +  +  +|  43        |
      Cyst                                 |                         3                                                |      3  2.7|
      Hemorrhage, Acute                    |                               3                                          |      2  2.5|
      Hyperplasia, Lymphoid                |       3                 2                                      2         |      6  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  M  M  +  +  +  +|  36        |
      Depletion Lymphoid                   |                                                    3                     |      1  3.0|
      Hematopoietic Cell Proliferation     |                                           2  3        2                  |      4  2.3|
      Hemorrhage, Acute                    |    2                                         1                           |      4  2.0|
      Hemorrhage, Subacute                 |                                                       2                  |      1  2.0|
      Hyperplasia, Lymphoid                |                                                                2         |      3  2.3|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hematopoietic Cell Proliferation     |                               4                 4                       3|      9  3.0|
      Hyperplasia, Lymphoid                |    2                                                        3            |      5  2.4|
      Pigmentation, Hemosiderin            |                            3        1                                    |      2  2.0|
      Capsule, Ectopic Tissue              |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  M  +|  44        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  35                                                               
NTP Experiment-Test: 05072-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:26:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 3| 6| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 2|            |
                             DAY ON TEST   | 2| 3| 3| 3| 3| 9| 3| 3| 3| 9| 1| 8| 1| 9| 3| 3| 9| 3| 3| 3| 3| 3| 3| 0| 6|            |
                                           | 4| 1| 1| 1| 2| 9| 2| 1| 2| 2| 5| 9| 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 1| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    0.5 PPM                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Depletion Lymphoid                   |                            3        2  3        3                        |      6  2.8|
      Ectopic Parathyroid Gland            |                                                                          |      1     |
      Hyperplasia, Lymphoid                |       2                                            3                     |      6  2.2|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Ectasia, Multifocal                  |                2           3                                   2         |      4  2.3|
      Hyperplasia, Diffuse                 |                            3        2        3  1     2     2  2         |      8  2.1|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +|  46        |
      Hair Follicle, Inflammation, Chronic |                                                                          |            |
          Active                           |                                  2                                       |      1  2.0|
      Subcutaneous Tissue, Edema           |                                        3                                 |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrous Osteodystrophy               |          1  3  2                          2     2           3            |     10  2.0|
      Osteoporosis, Focal                  | 2                                                                        |      1  2.0|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression                          |                            X                                   X         |      2     |
      Mineralization, Multifocal           |    2     3     1  2     2     2        2  1  3     2  2  2     2  1  2   |     26  1.8|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +     M  +|  45        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage, Acute, Multifocal        |                                                                         4|      1  4.0|
      Hemorrhage, Multifocal, Subacute     |                                                                          |      1  4.0|
      Infiltration Cellular, Diffuse,      |                                                                          |            |
          Lymphocyte                       | 2                                                                        |      1  2.0|
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |                                           2                              |      2  1.5|
      Inflammation, Acute, Focal           |                                                                          |      1  2.0|
      Pigmentation, Diffuse, Hemosiderin   |                                                                          |      1  3.0|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |    2     3                 1     2        2           2     4            |     13  2.3|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Multifocal                      |                   3                          4     2              2  4   |      7  2.9|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  36                                                               
NTP Experiment-Test: 05072-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:26:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 3| 6| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 2|            |
                             DAY ON TEST   | 2| 3| 3| 3| 3| 9| 3| 3| 3| 9| 1| 8| 1| 9| 3| 3| 9| 3| 3| 3| 3| 3| 3| 0| 6|            |
                                           | 4| 1| 1| 1| 2| 9| 2| 1| 2| 2| 5| 9| 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 1| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    0.5 PPM                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Diffuse, Histiocyte             |                                        2                                 |      2  2.0|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Multifocal, Histiocyte          |                2  3     1                                1           4   |      8  2.4|
      Bronchiole, Hyperplasia, Focal       |    2     3                                                               |      2  2.5|
      Bronchiole, Hyperplasia, Multifocal  |                   3                          4                       4   |      5  2.6|
      Interstitium, Inflammation, Chronic  |                                                                          |            |
          Active, Focal                    |          2                                                               |      1  2.0|
      Pleura, Infiltration Cellular,       |                                                                          |            |
          Lymphocyte                       |                                                                3         |      2  3.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lumen, Exudate                       |    2  2     1  3  1  1        1  1  2  2        1  1  1     2  2  2  1   |     30  1.6|
      Lumen, Foreign Body                  |    1                                                                     |      1  1.0|
      Mucosa, Inflammation, Chronic        |                                                                          |      1  2.0|
      Mucosa, Inflammation, Chronic Active |                1              2  1  1     1     1              2  1  2   |     10  1.3|
      Mucosa, Ulcer                        |                               2                                      2   |      2  2.0|
      Nasolacrimal Duct, Exudate           | 3                                                                        |      1  3.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Chronic                         |                                                                          |      1  2.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Chronic Active                  |                                                                          |      1  2.0|
      Olfactory Epithelium, Atrophy        |                            2                    1                        |      4  1.3|
      Respiratory Epithelium, Hyperplasia  |       1                       1                 2                    2   |      5  1.4|
      Respiratory Epithelium, Metaplasia,  |                                                                          |            |
           Squamous                        |                                     1                                3   |      2  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                |                                                                          |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   2        |
      Abscess                              |                                                                          |      1  4.0|
      Atrophy                              |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
      Inflammation, Chronic Active         |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infarct                              |          1                                                              4|      3  2.0|
      Infiltration Cellular, Lymphocyte    | 1  1  2        2                 2              2     1        2     1   |     14  1.4|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  37                                                               
NTP Experiment-Test: 05072-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:26:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 3| 6| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 2|            |
                             DAY ON TEST   | 2| 3| 3| 3| 3| 9| 3| 3| 3| 9| 1| 8| 1| 9| 3| 3| 9| 3| 3| 3| 3| 3| 3| 0| 6|            |
                                           | 4| 1| 1| 1| 2| 9| 2| 1| 2| 2| 5| 9| 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 1| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    0.5 PPM                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Nephropathy, Chronic                 |                            2           2                                 |      2  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |          1  1           1  1  1                       2     1  2     1   |     17  1.4|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  38                                                               
NTP Experiment-Test: 05072-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:26:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 7| 2| 2| 6| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 2| 3| 3| 3|             
                                           | 9| 7| 9| 9| 2| 0| 0| 0| 4| 0| 0| 0| 0| 0| 0| 0| 9| 0| 1| 0| 0| 9| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  A  +  +  +  +  +  +  M  M  +  +  +  +  +  +  M  +  +  +  +  +|             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |                                        2                                 |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Peyer's Patch, Hyperplasia, Lymphoid |             3              3           2                                 |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lumen, Hemorrhage, Acute             |                                                 4                        |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  M  +  M  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Peyer's Patch, Hyperplasia, Lymphoid |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lumen, Hemorrhage, Acute             |                                                 3                        |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                                          X               |             
      Basophilic Focus, Multiple           |                   X                                                      |             
      Cytomegaly, Multifocal               |                                                                          |             
      Eosinophilic Focus                   |                                                                          |             
      Fatty Change, Focal                  |                                                                          |             
      Hematopoietic Cell Proliferation,    |                                                                          |             
           Multifocal                      |                                                                          |             
      Hepatodiaphragmatic Nodule           |                                                                   X      |             
      Hyperplasia, Multifocal, Nodular     |                                                                          |             
      Infarct                              |                         4                                                |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |                                        2                                 |             
      Inflammation, Chronic, Multifocal    |                                                                          |             
      Inflammation, Multifocal, Subacute   |                                                             2            |             
      Mixed Cell Focus                     |                                                                          |             
      Necrosis, Acute, Multifocal          |                         4                                                |             
      Bile Duct, Hyperplasia, Multifocal   |    1                                   2                                 |             
      Centrilobular, Fatty Change,         |                                                                          |             
          Multifocal                       |                                                    2                     |             
      Centrilobular, Necrosis, Diffuse     |                                                                          |             
      Oval Cell, Hyperplasia               |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                                                          |             
      Duct, Cyst                           |                                              3                           |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |          2  1     1  1        1  2  2        1        2  1  1           1|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  39                                                               
NTP Experiment-Test: 05072-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:26:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 7| 2| 2| 6| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 2| 3| 3| 3|             
                                           | 9| 7| 9| 9| 2| 0| 0| 0| 4| 0| 0| 0| 0| 0| 0| 0| 9| 0| 1| 0| 0| 9| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active, Focal  |                                                                          |             
      Ulcer                                |                                                                          |             
      Epithelium, Hyperplasia, Diffuse     |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mucosa, Mineralization               |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                +         |             
      Dysplasia                            |                                                                          |             
      Inflammation, Chronic Active         |                                                                4         |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
      Artery, Inflammation, Chronic,       |                                                                          |             
          Multifocal                       |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Subcapsular, Hyperplasia, Focal      |                                                    2                    4|             
      Subcapsular, Hyperplasia, Multifocal | 2  1  2     1  2  1  2     1  2  1     3     2        1  1  2  1         |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |    3        3                                                            |             
      Hyperplasia, Multifocal              |                                                                      4   |             
      Hypertrophy, Focal                   | 2                                                                 2      |             
      Hypertrophy, Multifocal              |                               2        3              2                 3|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                                                          |             
      Hyperplasia, Multifocal              | 2  2  2  3     2     2  2        1     3        2  1  3           2      |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  M  +  M  +  +  +  M  M  +  M  +  +  +  +  +  +  M  M  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |                            2                                             |             
      Pars Distalis, Hyperplasia, Focal    |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic, Focal         |                                                                          |             
      Inflammation, Chronic, Multifocal    |                                                                          |             
      Follicle, Cyst, Multiple             |                                        2                                2|             
      Follicular Cell, Hyperplasia, Focal  |                                                                          |             
      Follicular Cell, Hyperplasia,        |                                                                          |             
          Multifocal                       |       1                                                  2               |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  40                                                               
NTP Experiment-Test: 05072-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:26:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 7| 2| 2| 6| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 2| 3| 3| 3|             
                                           | 9| 7| 9| 9| 2| 0| 0| 0| 4| 0| 0| 0| 0| 0| 0| 0| 9| 0| 1| 0| 0| 9| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                               +        +                                 |             
      Ectasia                              |                               2                                          |             
      Inflammation, Chronic                |                                        1                                 |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Ectasia, Multifocal                  |                                              2                           |             
      Inflammation, Chronic                |                   1                                                      |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inguinal, Hyperplasia, Lymphoid      |                            3                                             |             
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  M  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                             2            |             
      Hyperplasia                          |                                                                          |             
      Pigmentation, Hemosiderin            |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  M  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                   3                                   3        2        2|             
      Hemorrhage, Acute                    |    3        2              3  3  3        3     3  2        2  3  3     1|             
      Hemorrhage, Subacute                 |                2  2                                   2                  |             
      Hyperplasia, Lymphoid                |                2                                   2                     |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |    2        4     2                       3     4        3  3  2  4      |             
      Hyperplasia, Lymphoid                |                         2                                                |             
      Necrosis, Focal, Subacute            |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Depletion Lymphoid                   |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Necrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  +  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Prepuce, Inflammation, Chronic Active|                            4                                             |             
      Prepuce, Ulcer                       |                                                                          |             
      Subcutaneous Tissue, Edema           |                                                                          |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Focal, Granulomatous            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  41                                                               
NTP Experiment-Test: 05072-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:26:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 7| 2| 2| 6| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 2| 3| 3| 3|             
                                           | 9| 7| 9| 9| 2| 0| 0| 0| 4| 0| 0| 0| 0| 0| 0| 0| 9| 0| 1| 0| 0| 9| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |                1                                                     1   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization, Multifocal           |          3  3        3     2           2  1  3  1  2  1  3     1  3  2  3|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage, Acute                    |                                                                          |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |                            1     3                                       |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                        2                                 |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Focal, Histiocyte               |                                                                          |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Multifocal, Histiocyte          |          2              3                             2                  |             
      Mediastinum, Infiltration Cellular,  |                                                                          |             
           Multifocal, Lymphocyte          |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lumen, Exudate                       |                            1                                             |             
      Mucosa, Inflammation, Chronic Active |                                                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Chronic Active                  |                                                 2                        |             
      Respiratory Epithelium, Hyperplasia  |                            1                 1                           |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                           1                              |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                +                                                         |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydronephrosis                       |                                                       2                  |             
      Infiltration Cellular, Lymphocyte    | 2        1           2     1                 1  2        2  1            |             
      Mineralization, Multifocal           |                                                                          |             
      Nephropathy, Chronic                 |                                           1     2                        |             
      Bilateral, Hydronephrosis            |                                                                          |             
      Bilateral, Pelvis, Inflammation,     |                                                                          |             
           Acute                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  42                                                               
NTP Experiment-Test: 05072-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:26:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 7| 2| 2| 6| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 2| 3| 3| 3|             
                                           | 9| 7| 9| 9| 2| 0| 0| 0| 4| 0| 0| 0| 0| 0| 0| 0| 9| 0| 1| 0| 0| 9| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Medulla, Necrosis, Acute, Focal      |                                                                          |             
      Proximal Convoluted Renal Tubule,    |                                                                          |             
           Necrosis, Acute, Multifocal     |                                                                          |             
      Renal Tubule, Hyperplasia, Multifocal|                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic, Diffuse       |                                                 2                        |             
      Inflammation, Chronic, Multifocal    |                                                                          |             
      Inflammation, Chronic Active, Diffuse|                                                                          |             
      Ulcer, Multifocal                    |                                                                          |             
      Transitional Epithelium, Hyperplasia,|                                                                          |             
           Atypical, Diffuse               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  43                                                               
NTP Experiment-Test: 05072-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:26:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 7| 7| 7| 7| 7| 5| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 6| 6|            |
                             DAY ON TEST   | 2| 2| 4| 3| 3| 3| 3| 3| 2| 0| 6| 3| 5| 3| 3| 2| 3| 3| 3| 3| 2| 9| 2| 9| 5|            |
                                           | 9| 9| 6| 1| 1| 1| 1| 1| 9| 4| 2| 1| 4| 1| 1| 9| 1| 1| 1| 1| 9| 0| 9| 8| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  M  +  +  +  +  +  A  M  +  M  +  +  +  M  M  +  +  +  +  +  +  +|  40        |
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |                                  1                                       |      2  1.5|
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Peyer's Patch, Hyperplasia, Lymphoid |                3                    3                                2   |      6  2.7|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Lumen, Hemorrhage, Acute             |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
      Peyer's Patch, Hyperplasia, Lymphoid |                                                                         2|      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +     +  +  +  +  +  +  +|  46        |
      Lumen, Hemorrhage, Acute             |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     |                                                          X               |      2     |
      Basophilic Focus, Multiple           |                                                                          |      1     |
      Cytomegaly, Multifocal               |                   3                                                      |      1  3.0|
      Eosinophilic Focus                   |                   X                                                      |      1     |
      Fatty Change, Focal                  |                                              2                           |      1  2.0|
      Hematopoietic Cell Proliferation,    |                                                                          |            |
           Multifocal                      |                                           1                              |      1  1.0|
      Hepatodiaphragmatic Nodule           |                                                                          |      1     |
      Hyperplasia, Multifocal, Nodular     |                   3                                                      |      1  3.0|
      Infarct                              |                            4                                             |      2  4.0|
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |                                  3                 1              2      |      4  2.0|
      Inflammation, Chronic, Multifocal    |                                        2                                 |      1  2.0|
      Inflammation, Multifocal, Subacute   |                                                                   2      |      2  2.0|
      Mixed Cell Focus                     |                   X                                                      |      1     |
      Necrosis, Acute, Multifocal          |       3                                                              4   |      3  3.7|
      Bile Duct, Hyperplasia, Multifocal   |                   4                    4                                 |      4  2.8|
      Centrilobular, Fatty Change,         |                                                                          |            |
          Multifocal                       |                                              1                           |      2  1.5|
      Centrilobular, Necrosis, Diffuse     |                            4                                             |      1  4.0|
      Oval Cell, Hyperplasia               |                   2                                                      |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  44                                                               
NTP Experiment-Test: 05072-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:26:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 7| 7| 7| 7| 7| 5| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 6| 6|            |
                             DAY ON TEST   | 2| 2| 4| 3| 3| 3| 3| 3| 2| 0| 6| 3| 5| 3| 3| 2| 3| 3| 3| 3| 2| 9| 2| 9| 5|            |
                                           | 9| 9| 6| 1| 1| 1| 1| 1| 9| 4| 2| 1| 4| 1| 1| 9| 1| 1| 1| 1| 9| 0| 9| 8| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia, Focal                   |                                                                2         |      1  2.0|
      Duct, Cyst                           |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      | 1  1     1  3     1  2        1  1     1     1           1     1  1      |     25  1.3|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  M  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +  +  +  +|  46        |
      Inflammation, Chronic Active, Focal  |                                              2                           |      1  2.0|
      Ulcer                                |                                              1                           |      1  1.0|
      Epithelium, Hyperplasia, Diffuse     |             2                                                            |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +  +  +  +|  47        |
      Mucosa, Mineralization               |                         2                                                |      1  2.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                +        +                                                |   3        |
      Dysplasia                            |                3        2                                                |      2  2.5|
      Inflammation, Chronic Active         |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                     +                                    |   1        |
      Artery, Inflammation, Chronic,       |                                                                          |            |
          Multifocal                       |                                     4                                    |      1  4.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Subcapsular, Hyperplasia, Focal      |          2                                                  1            |      4  2.3|
      Subcapsular, Hyperplasia, Multifocal | 2           1  2  2  1  2     2     2  3     2  1     2  2     1     2  2|     32  1.7|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia, Focal                   |          2           2                                      2            |      5  2.4|
      Hyperplasia, Multifocal              |                                                                          |      1  4.0|
      Hypertrophy, Focal                   |    3                                            2     2     2            |      6  2.2|
      Hypertrophy, Multifocal              |                                  3                 3                     |      6  2.7|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|  47        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Focal                   |                                                    2                     |      1  2.0|
      Hyperplasia, Multifocal              |                2  2                 2                 3  2               |     18  2.1|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  M  +  +  +  +  +  M  +  M  M  +  M  +  +  M  +  M  +  M  +  +  +  M|  33        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Pars Distalis, Cyst                  |                                                                          |      1  2.0|
      Pars Distalis, Hyperplasia, Focal    |                2                                                         |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  45                                                               
NTP Experiment-Test: 05072-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:26:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 7| 7| 7| 7| 7| 5| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 6| 6|            |
                             DAY ON TEST   | 2| 2| 4| 3| 3| 3| 3| 3| 2| 0| 6| 3| 5| 3| 3| 2| 3| 3| 3| 3| 2| 9| 2| 9| 5|            |
                                           | 9| 9| 6| 1| 1| 1| 1| 1| 9| 4| 2| 1| 4| 1| 1| 9| 1| 1| 1| 1| 9| 0| 9| 8| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic, Focal         |                               1                                          |      1  1.0|
      Inflammation, Chronic, Multifocal    |                1                                                         |      1  1.0|
      Follicle, Cyst, Multiple             |                                                                2         |      3  2.0|
      Follicular Cell, Hyperplasia, Focal  |                                                                         2|      1  2.0|
      Follicular Cell, Hyperplasia,        |                                                                          |            |
          Multifocal                       |                                                             2            |      3  1.7|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | M                                   +                                    |   3        |
      Ectasia                              |                                     4                                    |      2  3.0|
      Inflammation, Chronic                |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Ectasia, Multifocal                  |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                                                          |      1  1.0|
      Inflammation, Chronic Active         |                                              2                           |      1  2.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inguinal, Hyperplasia, Lymphoid      |                      2              2                                    |      3  2.3|
      Mediastinal, Hyperplasia, Lymphoid   | 2                    4                                                   |      2  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  +  +  M  M  M  +  +  +  +  +  M  M  +  M  +  +  M  +  +  +  +  M  +  +|  37        |
      Hyperplasia, Lymphoid                |                      3                                                   |      2  2.5|
      Hyperplasia                          |                                                                         4|      1  4.0|
      Pigmentation, Hemosiderin            |                                                             2            |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Hematopoietic Cell Proliferation     |       2  2                    1  3           1     3           2     2  4|     13  2.3|
      Hemorrhage, Acute                    | 3     3     2     2  2        3  3     1  4  2     3     2     3  2     4|     27  2.6|
      Hemorrhage, Subacute                 |          2                                            2                  |      5  2.0|
      Hyperplasia, Lymphoid                |                      2                                                   |      3  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hematopoietic Cell Proliferation     |       3  2                 3  2     3     4        3                 4  3|     18  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  46                                                               
NTP Experiment-Test: 05072-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:26:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 7| 7| 7| 7| 7| 5| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 6| 6|            |
                             DAY ON TEST   | 2| 2| 4| 3| 3| 3| 3| 3| 2| 0| 6| 3| 5| 3| 3| 2| 3| 3| 3| 3| 2| 9| 2| 9| 5|            |
                                           | 9| 9| 6| 1| 1| 1| 1| 1| 9| 4| 2| 1| 4| 1| 1| 9| 1| 1| 1| 1| 9| 0| 9| 8| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia, Lymphoid                |                      3                                   3               |      3  2.7|
      Necrosis, Focal, Subacute            |                                                 3                        |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|  45        |
      Cyst                                 |                                                                      2   |      1  2.0|
      Depletion Lymphoid                   |       3                    3                                             |      2  3.0|
      Hyperplasia, Lymphoid                |                      3                                                   |      1  3.0|
      Necrosis                             |                                                                         2|      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  M  M  M  +  M  M  +     M  M  M  M  M  M  M  M  M  M  M  M  +|   4        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Prepuce, Inflammation, Chronic Active|                                     4                                    |      2  4.0|
      Prepuce, Ulcer                       |                                     4                                    |      1  4.0|
      Subcutaneous Tissue, Edema           |                            2                                             |      1  2.0|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Focal, Granulomatous            |                                                    4                     |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Fibrous Osteodystrophy               |                                                                         2|      3  1.3|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mineralization, Multifocal           | 2  3  1  1        2        2     2     3  3        2  2  1  2  2  3     3|     31  2.2|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                |                                                                   1      |      1  1.0|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage, Acute                    |                   3                                               2      |      2  2.5|
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |                   2                                2                     |      4  2.0|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |                                              1                           |      2  1.5|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Focal, Histiocyte               |    2                                                                     |      1  2.0|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Multifocal, Histiocyte          | 2                                         2     2                        |      6  2.2|
      Mediastinum, Infiltration Cellular,  |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  47                                                               
NTP Experiment-Test: 05072-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:26:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 7| 7| 7| 7| 7| 5| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 6| 6|            |
                             DAY ON TEST   | 2| 2| 4| 3| 3| 3| 3| 3| 2| 0| 6| 3| 5| 3| 3| 2| 3| 3| 3| 3| 2| 9| 2| 9| 5|            |
                                           | 9| 9| 6| 1| 1| 1| 1| 1| 9| 4| 2| 1| 4| 1| 1| 9| 1| 1| 1| 1| 9| 0| 9| 8| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
           Multifocal, Lymphocyte          |                                  2                                       |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Lumen, Exudate                       |                                                                          |      1  1.0|
      Mucosa, Inflammation, Chronic Active |                            1                                             |      1  1.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Chronic Active                  |                                                                          |      1  2.0|
      Respiratory Epithelium, Hyperplasia  |                         1                                                |      3  1.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |                                  1                                       |      2  1.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                      +   |   2        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hydronephrosis                       |                                                                          |      1  2.0|
      Infiltration Cellular, Lymphocyte    |    1     1     2  1                    1  1        2        1  1  1      |     18  1.3|
      Mineralization, Multifocal           | 1                                                                 1      |      2  1.0|
      Nephropathy, Chronic                 |          2                                                               |      3  1.7|
      Bilateral, Hydronephrosis            |                                                                2        2|      2  2.0|
      Bilateral, Pelvis, Inflammation,     |                                                                          |            |
           Acute                           |       2                       4                                          |      2  3.0|
      Medulla, Necrosis, Acute, Focal      |                                                                         2|      1  2.0|
      Proximal Convoluted Renal Tubule,    |                                                                          |            |
           Necrosis, Acute, Multifocal     |                                                                      3   |      1  3.0|
      Renal Tubule, Hyperplasia, Multifocal|                                                                   1      |      1  1.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Inflammation, Chronic, Diffuse       |                                                                          |      1  2.0|
      Inflammation, Chronic, Multifocal    |                                     2                                    |      1  2.0|
      Inflammation, Chronic Active, Diffuse|       4                       4                                          |      2  4.0|
      Ulcer, Multifocal                    |                               4                                          |      1  4.0|
      Transitional Epithelium, Hyperplasia,|                                                                          |            |
           Atypical, Diffuse               |                                     2                                    |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  48                                                               
NTP Experiment-Test: 05072-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:26:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| 4| 2| 6| 7| 7| 5| 7| 5| 6| 7| 7| 5| 5|             
                             DAY ON TEST   | 6| 2| 2| 2| 3| 7| 4| 3| 2| 1| 2| 4| 8| 9| 8| 2| 1| 8| 2| 9| 2| 2| 2| 5| 5|             
                                           | 0| 9| 9| 9| 0| 1| 9| 0| 9| 4| 9| 2| 5| 9| 4| 9| 8| 8| 9| 1| 5| 9| 9| 5| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    2 PPM                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | M     M  +  M  +  +  +  +  A  +  +  +  M  +  +  M  M  +  +  +  +  +  +  A|             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |                                                                2         |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +     +  +  A  +  +  +  +  +  +  A  A  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |                   2                                                      |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | A  +  +  +  +  +  +  +  +  A  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  M  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | A  +  +  +  +  A  +  +  +  A  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                         3                                                |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                            X                                X            |             
      Cytoplasmic Alteration, Multifocal   |                                           1                              |             
      Eosinophilic Focus                   |                                                                          |             
      Hematopoietic Cell Proliferation,    |                                                                          |             
           Multifocal                      |                                                                          |             
      Hepatodiaphragmatic Nodule           |                                                                          |             
      Infarct                              |                                                    4        4            |             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |                                                                          |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |                         2                                      2         |             
      Inflammation, Chronic, Multifocal    |                                              1                          2|             
      Necrosis, Acute, Multifocal          |                                                    4                     |             
      Thrombosis                           |                                                                          |             
      Bile Duct, Hyperplasia, Multifocal   |                                                                         2|             
      Centrilobular, Fatty Change,         |                                                                          |             
          Multifocal                       |                                     2                                    |             
      Centrilobular, Necrosis, Acute,      |                                                                          |             
          Multifocal                       |                                                                          |             
      Centrilobular, Necrosis, Diffuse     |                                                    4                     |             
      Kupffer Cell, Hyperplasia, Multifocal|                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Artery, Inflammation, Chronic Active |                                                                4         |             
      Duct, Dilatation                     |                                                                3         |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      | 1  1     2                       1                             1  1      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  49                                                               
NTP Experiment-Test: 05072-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:26:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| 4| 2| 6| 7| 7| 5| 7| 5| 6| 7| 7| 5| 5|             
                             DAY ON TEST   | 6| 2| 2| 2| 3| 7| 4| 3| 2| 1| 2| 4| 8| 9| 8| 2| 1| 8| 2| 9| 2| 2| 2| 5| 5|             
                                           | 0| 9| 9| 9| 0| 1| 9| 0| 9| 4| 9| 2| 5| 9| 4| 9| 8| 8| 9| 1| 5| 9| 9| 5| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    2 PPM                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Epithelium, Hyperplasia, Focal       |                                                             2            |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute, Focal           |                                                                      2   |             
      Inflammation, Chronic                |                                                                          |             
      Mucosa, Mineralization               |                                           2                              |             
                                            __________________________________________________________________________|             
   Tooth                                   |          +              +     +              +        +        +         |             
      Dysplasia                            |          4              4                    4        4                  |             
      Inflammation, Acute                  |                                                       2                  |             
      Inflammation, Chronic                |                         4                                      3         |             
      Inflammation, Chronic Active         |                               3              4                           |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute, Multifocal      |                                                                          |             
      Inflammation, Chronic, Multifocal    |                               3                                          |             
      Mitral Valve, Bacterium              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Capsule, Accessory Adrenal Cortical  |                                                                          |             
          Nodule                           |                               X                                      X   |             
      Subcapsular, Hyperplasia, Focal      |                                                                         4|             
      Subcapsular, Hyperplasia, Multifocal | 2  2     2  1        1  1  1  2  1        2  1  1     1     1     2  2   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   | 2                                            2                           |             
      Hypertrophy, Focal                   |    2                    1                                   1     2      |             
      Hypertrophy, Multifocal              |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                              1                           |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Multifocal              | 2        2  1  2     1           3        2     4     3  2              3|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  +  +  M  +  +  M  +  M  +  M  +  +  +  M  M  +  M  +  +  M  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicle, Cyst                       |                         2                                                |             
      Follicle, Cyst, Multiple             |                                                                          |             
      Follicular Cell, Hyperplasia, Focal  |                                                       1                  |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                           +     +                       +|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  50                                                               
NTP Experiment-Test: 05072-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:26:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| 4| 2| 6| 7| 7| 5| 7| 5| 6| 7| 7| 5| 5|             
                             DAY ON TEST   | 6| 2| 2| 2| 3| 7| 4| 3| 2| 1| 2| 4| 8| 9| 8| 2| 1| 8| 2| 9| 2| 2| 2| 5| 5|             
                                           | 0| 9| 9| 9| 0| 1| 9| 0| 9| 4| 9| 2| 5| 9| 4| 9| 8| 8| 9| 1| 5| 9| 9| 5| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    2 PPM                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic, Multifocal    |                                                    4                     |             
                                            __________________________________________________________________________|             
   Penis                                   |             +                                                            |             
      Inflammation, Chronic Active         |             2                                                            |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |             +                                                            |             
      Atrophy                              |             4                                                            |             
      Ectasia                              |             4                                                            |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +     +|             
      Inflammation, Acute, Suppurative     |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
      Hyperplasia, Focal, Re Cell          |          2                                                               |             
      Myeloid Cell, Hyperplasia            |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bronchial, Hyperplasia, Lymphoid     |                                                                          |             
      Inguinal, Hyperplasia, Plasma Cell   |                                                                          |             
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |             
      Mediastinal, Hyperplasia             |                         3                                                |             
      Mediastinal, Hyperplasia, Plasma Cell|                3                                                         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  M  +|             
      Hyperplasia, Lymphoid                |                                  3                             2         |             
      Hyperplasia, Re Cell                 |          3                       2                                       |             
      Pigmentation, Hemosiderin            |                                                    2     3               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  M  +  +  M  +  +  +     +  M  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                      4                                                   |             
      Hematopoietic Cell Proliferation     |                                                    2           2     1   |             
      Hemorrhage, Acute                    |             2           2                 3        3     4     3  2  1  3|             
      Hemorrhage, Subacute                 |                                                                          |             
      Hyperplasia, Lymphoid                |                   2     2                                                |             
      Hyperplasia, Re Cell                 |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis, Multifocal              |                                                                          |             
      Fibrosis, Diffuse                    |                                                                          |             
      Hematopoietic Cell Proliferation     |                   2                 2                                    |             
      Hyperplasia, Lymphoid                |                                                                         2|             
      Hyperplasia, Re Cell                 |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  M  M     M  +  +  +  +  +  +  +  +  M  M  +  M  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  51                                                               
NTP Experiment-Test: 05072-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:26:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| 4| 2| 6| 7| 7| 5| 7| 5| 6| 7| 7| 5| 5|             
                             DAY ON TEST   | 6| 2| 2| 2| 3| 7| 4| 3| 2| 1| 2| 4| 8| 9| 8| 2| 1| 8| 2| 9| 2| 2| 2| 5| 5|             
                                           | 0| 9| 9| 9| 0| 1| 9| 0| 9| 4| 9| 2| 5| 9| 4| 9| 8| 8| 9| 1| 5| 9| 9| 5| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    2 PPM                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Depletion Lymphoid                   | 3                          4        4                                4   |             
      Hyperplasia, Lymphoid                |                                        3                                 |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  +  M  M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Prepuce, Inflammation, Chronic Active|                                                                          |             
      Prepuce, Ulcer                       |                                                                          |             
      Subcutaneous Tissue, Abscess, Chronic|                                                          4               |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Diffuse, Subacute               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Osteoporosis                         |                                                                2         |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                           +     +  +     +           +   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                                                                          |             
      Hemorrhage, Acute, Multifocal        |                                                                          |             
      Infarct, Subacute                    |                                                                          |             
      Inflammation, Acute, Focal           |                                                                          |             
      Mineralization, Multifocal           | 2  1  3  2  2  3        2  2     1  2        2  2     1  1  3        2   |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage, Acute                    |                                     4              4                     |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |          2                                                               |             
      Inflammation, Acute, Focal           |                                                                          |             
      Necrosis, Acute, Multifocal          |                                                                          |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                              3                           |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Multifocal                      | 4  2  2     2  2  2  4  2  4  4  3  1     2     3  2  4  4  3  4  3  2  3|             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Diffuse, Histiocyte             |    2           4                                                         |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Multifocal, Histiocyte          |       3  2  3        4     3  4  4           4              3            |             
      Bronchiole, Hyperplasia, Multifocal  |    2  2  2  2  2  2  4  2  4  4  3        2     3  2     4  3  4  3  2  3|             
      Bronchiole, Alveolus, Inflammation,  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  52                                                               
NTP Experiment-Test: 05072-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:26:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| 4| 2| 6| 7| 7| 5| 7| 5| 6| 7| 7| 5| 5|             
                             DAY ON TEST   | 6| 2| 2| 2| 3| 7| 4| 3| 2| 1| 2| 4| 8| 9| 8| 2| 1| 8| 2| 9| 2| 2| 2| 5| 5|             
                                           | 0| 9| 9| 9| 0| 1| 9| 0| 9| 4| 9| 2| 5| 9| 4| 9| 8| 8| 9| 1| 5| 9| 9| 5| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    2 PPM                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
           Acute, Multifocal, Suppurative  |                4                                                         |             
      Mediastinum, Infiltration Cellular,  |                                                                          |             
           Multifocal, Lymphocyte          |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lumen, Exudate                       | 2     2  2  2  3     2     1  2        1  2     2     1        2  1  1   |             
      Mucosa, Inflammation, Acute          |                                           1                              |             
      Mucosa, Inflammation, Chronic Active |                                  2                                       |             
      Nasolacrimal Duct, Exudate           |                                                 3                        |             
      Nasolacrimal Duct, Hyperplasia       |                                                 3                        |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Acute                           |                                                 2                        |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Chronic Active                  |                                                                          |             
      Olfactory Epithelium, Atrophy        |                   1                                                      |             
      Respiratory Epithelium, Hyperplasia  |                            1                                         1   |             
      Respiratory Epithelium, Ulcer, Focal |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                +         |             
                                            __________________________________________________________________________|             
   Lacrimal Gland                          |                                                       +                  |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |                                                       1                  |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                                          |             
      Abscess, Multiple                    |                                                                          |             
      Hydronephrosis                       |                                        2                                 |             
      Infarct                              |                         3     4        2                                 |             
      Infiltration Cellular, Lymphocyte    |          3                                            1  3        1      |             
      Mineralization, Multifocal           |                                                                          |             
      Bilateral, Pelvis, Inflammation,     |                                                                          |             
           Acute                           |                                                                          |             
      Capsule, Fibrosis, Focal             |                                                             3            |             
      Renal Tubule, Hyperplasia, Atypical, |                                                                          |             
           Focal                           |                                                                   2      |             
      Renal Tubule, Hyperplasia, Focal     |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +     +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |                                                                          |             
      Inflammation, Chronic, Diffuse       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  53                                                               
NTP Experiment-Test: 05072-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:26:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 3| 6| 5| 7| 5| 7| 6| 1| 6| 7| 7| 6| 6| 6| 7| 7| 6| 5| 5| 7| 6| 6| 5| 5|            |
                             DAY ON TEST   | 1| 7| 5| 7| 2| 4| 3| 4| 4| 0| 1| 3| 5| 9| 1| 2| 1| 2| 3| 1| 3| 1| 5| 6| 1|            |
                                           | 7| 6| 2| 1| 9| 6| 0| 2| 5| 4| 7| 0| 9| 1| 4| 2| 0| 7| 7| 4| 0| 4| 4| 5| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    2 PPM                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  M     A  +  A  +  +  +  A  +  +  +  M  +  +  M  +  +  A  +  +  A  +  A|  31        |
      Infiltration Cellular, Focal,        |                                                                          |            |
          Lymphocyte                       |             2                                                            |      2  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  M  A  M  +  A  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  40        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  M  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  M|  43        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  A  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A|  44        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  A  +  +  M  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  44        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  A  +  +  +  +  M  +  +  +  +  +  +  +  A     +  +  +  +  +  +  +|  42        |
      Hyperplasia                          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     |                                                                          |      2     |
      Cytoplasmic Alteration, Multifocal   |                                                                          |      1  1.0|
      Eosinophilic Focus                   |                   X                                                      |      1     |
      Hematopoietic Cell Proliferation,    |                                                                          |            |
           Multifocal                      |                                           2                          2   |      2  2.0|
      Hepatodiaphragmatic Nodule           |                                                 X                        |      1     |
      Infarct                              |                                                                          |      2  4.0|
      Infiltration Cellular, Focal,        |                                                                          |            |
          Lymphocyte                       |             2                                                            |      1  2.0|
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |                      1                                                   |      3  1.7|
      Inflammation, Chronic, Multifocal    |                                                                          |      2  1.5|
      Necrosis, Acute, Multifocal          |                4                                                         |      2  4.0|
      Thrombosis                           | 4                                                                        |      1  4.0|
      Bile Duct, Hyperplasia, Multifocal   |                               1     3                                    |      3  2.0|
      Centrilobular, Fatty Change,         |                                                                          |            |
          Multifocal                       |                                                                          |      1  2.0|
      Centrilobular, Necrosis, Acute,      |                                                                          |            |
          Multifocal                       | 4                                                                        |      1  4.0|
      Centrilobular, Necrosis, Diffuse     |                                                                          |      1  4.0|
      Kupffer Cell, Hyperplasia, Multifocal|                               2                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                               +                                          |   1        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +|  49        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  54                                                               
NTP Experiment-Test: 05072-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:26:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 3| 6| 5| 7| 5| 7| 6| 1| 6| 7| 7| 6| 6| 6| 7| 7| 6| 5| 5| 7| 6| 6| 5| 5|            |
                             DAY ON TEST   | 1| 7| 5| 7| 2| 4| 3| 4| 4| 0| 1| 3| 5| 9| 1| 2| 1| 2| 3| 1| 3| 1| 5| 6| 1|            |
                                           | 7| 6| 2| 1| 9| 6| 0| 2| 5| 4| 7| 0| 9| 1| 4| 2| 0| 7| 7| 4| 0| 4| 4| 5| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    2 PPM                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Artery, Inflammation, Chronic Active |                                                                          |      1  4.0|
      Duct, Dilatation                     |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |                                        1                                 |      7  1.1|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Epithelium, Hyperplasia, Focal       |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Acute, Focal           |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                                                         3|      1  3.0|
      Mucosa, Mineralization               |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                   +           +                                          |   8        |
      Dysplasia                            |                               3                                          |      5  3.8|
      Inflammation, Acute                  |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                                                          |      2  3.5|
      Inflammation, Chronic Active         |                   3                                                      |      3  3.3|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Acute, Multifocal      |                3                                                         |      1  3.0|
      Inflammation, Chronic, Multifocal    |                                                                          |      1  3.0|
      Mitral Valve, Bacterium              |                4                                                         |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Capsule, Accessory Adrenal Cortical  |                                                                          |            |
          Nodule                           |                                                    X                     |      3     |
      Subcapsular, Hyperplasia, Focal      |                            2        2                                    |      3  2.7|
      Subcapsular, Hyperplasia, Multifocal | 1     1     2     1              1        1  2     2  2     1  1  2      |     28  1.4|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Focal                   |                                  2           3                           |      4  2.3|
      Hypertrophy, Focal                   |          2           2              2                                    |      7  1.7|
      Hypertrophy, Multifocal              |       1                                                                  |      1  1.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +     +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Hyperplasia, Focal                   |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +|  48        |
      Hyperplasia, Multifocal              | 3     2  3  2     1           1  2     3     3     1        2        1   |     23  2.1|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  M  +  +  +  M  +  +  M  M  M  +  +  +  +  +  +  M  +  +  M  +  +  +  +|  34        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  55                                                               
NTP Experiment-Test: 05072-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:26:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 3| 6| 5| 7| 5| 7| 6| 1| 6| 7| 7| 6| 6| 6| 7| 7| 6| 5| 5| 7| 6| 6| 5| 5|            |
                             DAY ON TEST   | 1| 7| 5| 7| 2| 4| 3| 4| 4| 0| 1| 3| 5| 9| 1| 2| 1| 2| 3| 1| 3| 1| 5| 6| 1|            |
                                           | 7| 6| 2| 1| 9| 6| 0| 2| 5| 4| 7| 0| 9| 1| 4| 2| 0| 7| 7| 4| 0| 4| 4| 5| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    2 PPM                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Follicle, Cyst                       |                                     1                                    |      2  1.5|
      Follicle, Cyst, Multiple             | 2                                                              2         |      2  2.0|
      Follicular Cell, Hyperplasia, Focal  |                            2                                             |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |       +  +                 +                             +               |   7        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic, Multifocal    |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Penis                                   |                +                                                         |   2        |
      Inflammation, Chronic Active         |                4                                                         |      2  3.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |    +                                                  +     +            |   4        |
      Atrophy                              |    3                                                                     |      2  3.5|
      Ectasia                              |    4                                                        3            |      3  3.7|
      Inflammation, Chronic                |                                                       2     2            |      2  2.0|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +     M  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Inflammation, Acute, Suppurative     |                                           3                              |      1  3.0|
      Inflammation, Chronic Active         |                4                                                        3|      2  3.5|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Abscess                              |                4                                                         |      1  4.0|
      Inflammation, Chronic                |                   2                                                      |      1  2.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia, Focal, Re Cell          |                                                                          |      1  2.0|
      Myeloid Cell, Hyperplasia            |                                           3           3                  |      2  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Bronchial, Hyperplasia, Lymphoid     |                                                    3                     |      1  3.0|
      Inguinal, Hyperplasia, Plasma Cell   |                                           3                              |      1  3.0|
      Mediastinal, Hyperplasia, Lymphoid   | 2                                                                        |      1  2.0|
      Mediastinal, Hyperplasia             |             2     2                                                      |      3  2.3|
      Mediastinal, Hyperplasia, Plasma Cell|                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +|  43        |
      Hyperplasia, Lymphoid                |                                                                          |      2  2.5|
      Hyperplasia, Re Cell                 |                                                                          |      2  2.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  56                                                               
NTP Experiment-Test: 05072-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:26:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 3| 6| 5| 7| 5| 7| 6| 1| 6| 7| 7| 6| 6| 6| 7| 7| 6| 5| 5| 7| 6| 6| 5| 5|            |
                             DAY ON TEST   | 1| 7| 5| 7| 2| 4| 3| 4| 4| 0| 1| 3| 5| 9| 1| 2| 1| 2| 3| 1| 3| 1| 5| 6| 1|            |
                                           | 7| 6| 2| 1| 9| 6| 0| 2| 5| 4| 7| 0| 9| 1| 4| 2| 0| 7| 7| 4| 0| 4| 4| 5| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    2 PPM                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Pigmentation, Hemosiderin            |                            3                                             |      3  2.7|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | M  +  M  +  +  M     +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|  39        |
      Angiectasis                          |                                                                          |      1  4.0|
      Hematopoietic Cell Proliferation     |             2                                                        3   |      5  2.0|
      Hemorrhage, Acute                    |          4  3        4     2  3  3  3  2     4                 3         |     19  2.8|
      Hemorrhage, Subacute                 |                                                                   3      |      1  3.0|
      Hyperplasia, Lymphoid                |                                        3           3                     |      4  2.5|
      Hyperplasia, Re Cell                 |                                        2                                 |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis, Multifocal              |                                  3                                       |      1  3.0|
      Fibrosis, Diffuse                    |                                  3                                       |      1  3.0|
      Hematopoietic Cell Proliferation     | 4                    2                 2              2           3  2   |      8  2.4|
      Hyperplasia, Lymphoid                |                                              3                           |      2  2.5|
      Hyperplasia, Re Cell                 |                                                    1                     |      1  1.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  M  +  +  +  M  M  +  +  M  M  +  +  M  M  M  +  +  +  +  M  +  M  +  M|  32        |
      Depletion Lymphoid                   |       4                                                  4               |      6  3.8|
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  +  M  M  M  M  M  +  M  M  M  M  M  M  M  M  M  M  M  M  M  M  +  M  M|   4        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Prepuce, Inflammation, Chronic Active|                4                                      4        4         |      3  4.0|
      Prepuce, Ulcer                       |                3                                      3        4         |      3  3.3|
      Subcutaneous Tissue, Abscess, Chronic|                                                                          |      1  4.0|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Diffuse, Subacute               |                                           2                              |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Osteoporosis                         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                   +      |   6        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression                          |                         X                                                |      1     |
      Hemorrhage, Acute, Multifocal        |                                              3                           |      1  3.0|
      Infarct, Subacute                    |          4                                                               |      1  4.0|
      Inflammation, Acute, Focal           |                2                                                         |      1  2.0|
      Mineralization, Multifocal           |       3  3  2  2  2  3     3        1  2  1                 1  3  1  2   |     30  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  57                                                               
NTP Experiment-Test: 05072-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:26:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 3| 6| 5| 7| 5| 7| 6| 1| 6| 7| 7| 6| 6| 6| 7| 7| 6| 5| 5| 7| 6| 6| 5| 5|            |
                             DAY ON TEST   | 1| 7| 5| 7| 2| 4| 3| 4| 4| 0| 1| 3| 5| 9| 1| 2| 1| 2| 3| 1| 3| 1| 5| 6| 1|            |
                                           | 7| 6| 2| 1| 9| 6| 0| 2| 5| 4| 7| 0| 9| 1| 4| 2| 0| 7| 7| 4| 0| 4| 4| 5| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    2 PPM                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                      +   |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage, Acute                    |                                                 3        4               |      4  3.8|
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |                                                                          |      1  2.0|
      Inflammation, Acute, Focal           |                                              4                           |      1  4.0|
      Necrosis, Acute, Multifocal          |                                     2                             3      |      2  2.5|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |                                                                          |      1  3.0|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Multifocal                      | 3  3  4  3  3  1  4  2     2  3  3  4  3  2  4  3  3  3  1  4  4  2  2   |     45  2.8|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Diffuse, Histiocyte             |                                                                          |      2  3.0|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Multifocal, Histiocyte          | 3           3     4           3     2  2     4  3  3        3     3      |     20  3.2|
      Bronchiole, Hyperplasia, Multifocal  | 3     4  3  3  1  4  2     2  3  3  4  3  2     3  3  3  1  4  4     2   |     40  2.8|
      Bronchiole, Alveolus, Inflammation,  |                                                                          |            |
           Acute, Multifocal, Suppurative  |                                                                          |      1  4.0|
      Mediastinum, Infiltration Cellular,  |                                                                          |            |
           Multifocal, Lymphocyte          |                                     3                                    |      1  3.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Lumen, Exudate                       |       2        1  3  1        2  2  2        3  3  3  2     2     3     1|     29  1.9|
      Mucosa, Inflammation, Acute          |                                                                          |      1  1.0|
      Mucosa, Inflammation, Chronic Active | 2              1  1                                            3         |      5  1.8|
      Nasolacrimal Duct, Exudate           |                                                                          |      1  3.0|
      Nasolacrimal Duct, Hyperplasia       |                                                                          |      1  3.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Acute                           |                                                                          |      1  2.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Chronic Active                  |                2                                                         |      1  2.0|
      Olfactory Epithelium, Atrophy        |                                                                          |      1  1.0|
      Respiratory Epithelium, Hyperplasia  | 2              1                             1                           |      5  1.2|
      Respiratory Epithelium, Ulcer, Focal |                                              2                           |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  58                                                               
NTP Experiment-Test: 05072-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:26:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 3| 6| 5| 7| 5| 7| 6| 1| 6| 7| 7| 6| 6| 6| 7| 7| 6| 5| 5| 7| 6| 6| 5| 5|            |
                             DAY ON TEST   | 1| 7| 5| 7| 2| 4| 3| 4| 4| 0| 1| 3| 5| 9| 1| 2| 1| 2| 3| 1| 3| 1| 5| 6| 1|            |
                                           | 7| 6| 2| 1| 9| 6| 0| 2| 5| 4| 7| 0| 9| 1| 4| 2| 0| 7| 7| 4| 0| 4| 4| 5| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    2 PPM                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Lacrimal Gland                          |                                                                          |   1        |
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Abscess                              |                                           4                              |      1  4.0|
      Abscess, Multiple                    |                4                                                         |      1  4.0|
      Hydronephrosis                       |                                                       3                  |      2  2.5|
      Infarct                              |                                                                          |      3  3.0|
      Infiltration Cellular, Lymphocyte    |                   1  2                                               2   |      7  1.9|
      Mineralization, Multifocal           |          3                                                               |      1  3.0|
      Bilateral, Pelvis, Inflammation,     |                                                                          |            |
           Acute                           |                                           3                              |      1  3.0|
      Capsule, Fibrosis, Focal             |                                                                          |      1  3.0|
      Renal Tubule, Hyperplasia, Atypical, |                                                                          |            |
           Focal                           |                                                                          |      1  2.0|
      Renal Tubule, Hyperplasia, Focal     |                   1                                                      |      1  1.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |                            1                                             |      1  1.0|
      Inflammation, Chronic, Diffuse       |                                                                         4|      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  59                                                               
NTP Experiment-Test: 05072-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:26:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 6| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 0| 7| 7| 5| 6| 6| 0| 5| 7|             
                             DAY ON TEST   | 3| 7| 3| 3| 5| 3| 5| 3| 3| 3| 8| 3| 3| 3| 3| 3| 4| 3| 3| 8| 4| 5| 3| 3| 3|             
                                           | 2| 8| 0| 0| 7| 0| 7| 0| 0| 0| 0| 0| 1| 1| 1| 1| 8| 2| 2| 8| 3| 7| 0| 4| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    0.5 PPM                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  A  +  +|             
      Ectasia                              |                                                                      4   |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |          2                                   2                           |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +|             
      Peyer's Patch, Hyperplasia, Lymphoid |                                              4                           |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectopic Tissue                       |                                                                         X|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  M  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis, Multifocal              |                               2                                          |             
      Basophilic Focus                     |                         X                                                |             
      Fatty Change, Multifocal             |                               2                                          |             
      Hematopoietic Cell Proliferation,    |                                                                          |             
           Multifocal                      |                                                                      2   |             
      Hyperplasia, Focal                   |                               3                                          |             
      Infarct                              |                   4                                      4               |             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |          1                                                               |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |                      1                                                   |             
      Inflammation, Chronic, Multifocal    |                1                                                         |             
      Inflammation, Granulomatous,         |                                                                          |             
          Multifocal                       |                                                                          |             
      Inflammation, Multifocal, Subacute   |          1                                   2                       1   |             
      Mitotic Alteration                   |                               3                                          |             
      Necrosis, Acute, Multifocal          |                                                          4               |             
      Necrosis, Chronic, Multifocal        |                                                                          |             
      Pigmentation, Multifocal             |                                                                          |             
      Artery, Mineralization, Multifocal   |                                                                          |             
      Bile Duct, Hyperplasia, Multifocal   |                               3              1                           |             
      Hepatocyte, Atrophy, Multifocal      |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Angiectasis, Multifocal              |                                                                          |             
      Fat, Inflammation, Chronic           |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +|             
      Infiltration Cellular, Multifocal,   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  60                                                               
NTP Experiment-Test: 05072-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:26:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 6| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 0| 7| 7| 5| 6| 6| 0| 5| 7|             
                             DAY ON TEST   | 3| 7| 3| 3| 5| 3| 5| 3| 3| 3| 8| 3| 3| 3| 3| 3| 4| 3| 3| 8| 4| 5| 3| 3| 3|             
                                           | 2| 8| 0| 0| 7| 0| 7| 0| 0| 0| 0| 0| 1| 1| 1| 1| 8| 2| 2| 8| 3| 7| 0| 4| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    0.5 PPM                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
           Lymphocyte                      |       2  1     1  1  1           1  2  1           2  1     1  1        1|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Tooth                                   |             +  +                                                         |             
      Abscess                              |             4                                                            |             
      Dysplasia                            |             4  2                                                         |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Mesenteric Artery, Inflammation,     |                                                                          |             
           Chronic                         |                                                                          |             
      Mesenteric Artery, Thrombosis        |                                                                          |             
      Renal Artery, Inflammation, Chronic, |                                                                          |             
           Multifocal                      |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |                                                                          |             
      Inflammation, Chronic, Focal         |                                                                1         |             
      Aortic Valve, Inflammation, Chronic  |                                                                          |             
          Active, Focal                    |                                                                          |             
      Epicardium, Hyperplasia, Focal       |                                                                          |             
      Mitral Valve, Inflammation, Focal,   |                                                                          |             
           Subacute                        |                                              3                           |             
      Perivascular, Granuloma              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Subcapsular, Hyperplasia, Focal      |          3  2              2  2                                          |             
      Subcapsular, Hyperplasia, Multifocal | 2     1        1  2                 1  2  2  2     2     2  2  2     1  1|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  M  +  +|             
      Cyst                                 |                                                                          |             
      Hyperplasia, Focal                   |             3     3           1                    2     2               |             
      Hyperplasia, Multifocal              |                2                    3                                    |             
      Hypertrophy, Focal                   |                            3                                2            |             
      Hypertrophy, Multifocal              |                         3                                                |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  M  +  +  +  M  +  +|             
      Hyperplasia, Focal                   |                               2                                          |             
      Hyperplasia, Multifocal              |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Hyperplasia, Focal                   |                                                                          |             
      Hyperplasia, Multifocal              |                      4                                                   |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  M  +  M  M  +  M  +  M  +  +  +  +  +  M  M  +  M  +  +  M  M  M  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  61                                                               
NTP Experiment-Test: 05072-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:26:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 6| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 0| 7| 7| 5| 6| 6| 0| 5| 7|             
                             DAY ON TEST   | 3| 7| 3| 3| 5| 3| 5| 3| 3| 3| 8| 3| 3| 3| 3| 3| 4| 3| 3| 8| 4| 5| 3| 3| 3|             
                                           | 2| 8| 0| 0| 7| 0| 7| 0| 0| 0| 0| 0| 1| 1| 1| 1| 8| 2| 2| 8| 3| 7| 0| 4| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    0.5 PPM                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pars Distalis, Cyst                  |                2                                                         |             
      Pars Distalis, Cyst, Multiple        |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +|             
      Follicle, Cyst                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granuloma                            |                                                                          |             
      Granuloma Sperm                      |                                                                          |             
                                            __________________________________________________________________________|             
   Penis                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                                                                         +|             
      Abscess                              |                                                                          |             
      Ectasia                              |                                                                          |             
      Inflammation, Chronic                |                                                                         3|             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia, Multifocal                  |                                                    3                     |             
      Granuloma                            |                                                                      4   |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |          2                                                               |             
      Inflammation, Chronic Active         |                                                                          |             
      Serosa, Inflammation, Acute, Focal,  |                                                                          |             
           Suppurative                     |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              | 4                                                                    4   |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Interstitial Cell, Hyperplasia,      |                                                                          |             
          Diffuse                          |                            2                       2                     |             
      Seminiferous Tubule, Atrophy,        |                                                                          |             
          Multifocal                       |                            3                 3                           |             
      Seminiferous Tubule, Degeneration,   |                                                                          |             
           Multifocal                      |                                                                         2|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Metaplasia, Focal, Osseous           |                                                                          |             
      Myeloid Cell, Hyperplasia            |                                                                      3   |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inguinal, Hyperplasia                |                                                                         2|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  M  M  +  +  +  +  M  +  +  +  M  +  +  +  M  +  M  +  +|             
      Hyperplasia, Lymphoid                | 2                                                                        |             
      Pigmentation, Hemosiderin            |                                  2                                       |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  62                                                               
NTP Experiment-Test: 05072-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:26:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 6| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 0| 7| 7| 5| 6| 6| 0| 5| 7|             
                             DAY ON TEST   | 3| 7| 3| 3| 5| 3| 5| 3| 3| 3| 8| 3| 3| 3| 3| 3| 4| 3| 3| 8| 4| 5| 3| 3| 3|             
                                           | 2| 8| 0| 0| 7| 0| 7| 0| 0| 0| 0| 0| 1| 1| 1| 1| 8| 2| 2| 8| 3| 7| 0| 4| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    0.5 PPM                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                           2  2              2        3   |             
      Hemorrhage, Acute                    | 4        3  2  3     2     2              2  3     1        2        3  2|             
      Hemorrhage, Subacute                 |                               1  2                    2                  |             
      Hyperplasia, Lymphoid                |                3                                   2                    3|             
      Pigmentation, Hemosiderin            |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                               3                          2     2         |             
      Hyperplasia, Lymphoid                |                                                                         2|             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  M  M  +  M  M  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Prepuce, Inflammation, Chronic Active|                                                                          |             
      Prepuce, Ulcer                       |                                                                          |             
      Subcutaneous Tissue, Edema           |                                                                          |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Focal, Subacute                 | 4                                                                        |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Sternum, Developmental Malformation  |                                                                         3|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization, Multifocal           | 2     3        3  2  2        2  2  2  2  2        3  2     2        1  2|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         |                                                                2         |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage, Acute                    |                                                                          |             
      Hemorrhage, Subacute                 |                                  2                                       |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |                                                                          |             
      Thrombosis                           |                               2                                          |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |    2     4        1  3  2        2                       2               |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Multifocal                      | 2           1                                                           1|             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Diffuse, Histiocyte             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  63                                                               
NTP Experiment-Test: 05072-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:26:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 6| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 0| 7| 7| 5| 6| 6| 0| 5| 7|             
                             DAY ON TEST   | 3| 7| 3| 3| 5| 3| 5| 3| 3| 3| 8| 3| 3| 3| 3| 3| 4| 3| 3| 8| 4| 5| 3| 3| 3|             
                                           | 2| 8| 0| 0| 7| 0| 7| 0| 0| 0| 0| 0| 1| 1| 1| 1| 8| 2| 2| 8| 3| 7| 0| 4| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    0.5 PPM                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Multifocal, Histiocyte          |    2        2                                                        3   |             
      Artery, Thrombosis, Multifocal       |                                                                          |             
      Bronchiole, Hyperplasia, Focal       |                         2        2                          2            |             
      Bronchiole, Hyperplasia, Multifocal  |                                                                         1|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lumen, Exudate                       |                                                                          |             
      Mucosa, Inflammation, Chronic Active |                                                                      2   |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Chronic Active                  |                                                                          |             
      Respiratory Epithelium, Hyperplasia  |                            1              1  1                           |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                       +                  |             
      Atrophy                              |                                                       4                  |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                       +                  |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydronephrosis                       |    2           2                                            2            |             
      Infarct                              |                                                                          |             
      Infiltration Cellular, Plasma Cell   |                                                                      2   |             
      Infiltration Cellular, Lymphocyte    |             1        1  1           1        1     2  2        2        1|             
      Nephropathy, Chronic                 |                               1                       1                  |             
      Cortex, Cyst                         |                                                                          |             
      Pelvis, Inflammation, Acute          |                                                                          |             
      Renal Tubule, Cytoplasmic Alteration,|                                                                          |             
           Multifocal                      |                                                                          |             
      Renal Tubule, Hyperplasia, Atypical, |                                                                          |             
           Focal                           |                                                                          |             
      Renal Tubule, Hyperplasia, Multifocal|                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  64                                                               
NTP Experiment-Test: 05072-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:26:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 5| 7| 6| 6| 7| 7| 7| 7| 7| 6| 6| 5| 5| 6| 6| 7| 4| 6| 7| 6| 7| 7|            |
                             DAY ON TEST   | 3| 7| 0| 9| 3| 8| 2| 3| 3| 3| 3| 3| 2| 8| 6| 8| 9| 7| 3| 2| 4| 3| 2| 3| 3|            |
                                           | 2| 8| 6| 2| 2| 4| 9| 2| 2| 2| 2| 2| 2| 8| 6| 7| 2| 8| 2| 6| 3| 2| 1| 2| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    0.5 PPM                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  M  +  +  +  A  M  +  +  +  +  +  A  A  +  +  +  +  +  +     +  +  +  M|  39        |
      Ectasia                              |                                                                          |      1  4.0|
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |                                  1                                       |      3  1.7|
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Peyer's Patch, Hyperplasia, Lymphoid |                                                             2           2|      3  2.7|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  A  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Ectopic Tissue                       |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  A  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis, Multifocal              |                                                                          |      1  2.0|
      Basophilic Focus                     |                                  X                                       |      2     |
      Fatty Change, Multifocal             |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation,    |                                                                          |            |
           Multifocal                      |                                                 3                        |      2  2.5|
      Hyperplasia, Focal                   |                                                                          |      1  3.0|
      Infarct                              | 4        4           3                                                   |      5  3.8|
      Infiltration Cellular, Focal,        |                                                                          |            |
          Lymphocyte                       |                                                                          |      1  1.0|
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |                                                                          |      1  1.0|
      Inflammation, Chronic, Multifocal    |                                  1                    1                  |      3  1.0|
      Inflammation, Granulomatous,         |                                                                          |            |
          Multifocal                       |                      3                                                   |      1  3.0|
      Inflammation, Multifocal, Subacute   |                                                             2            |      4  1.5|
      Mitotic Alteration                   |                                                                          |      1  3.0|
      Necrosis, Acute, Multifocal          |                                     4              3                     |      3  3.7|
      Necrosis, Chronic, Multifocal        |          2                                                               |      1  2.0|
      Pigmentation, Multifocal             |                                                 3                        |      1  3.0|
      Artery, Mineralization, Multifocal   |                      3                                                   |      1  3.0|
      Bile Duct, Hyperplasia, Multifocal   |                                  1                                       |      3  1.7|
      Hepatocyte, Atrophy, Multifocal      |                                                             2            |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                               +        +           +                     |   3        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  65                                                               
NTP Experiment-Test: 05072-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:26:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 5| 7| 6| 6| 7| 7| 7| 7| 7| 6| 6| 5| 5| 6| 6| 7| 4| 6| 7| 6| 7| 7|            |
                             DAY ON TEST   | 3| 7| 0| 9| 3| 8| 2| 3| 3| 3| 3| 3| 2| 8| 6| 8| 9| 7| 3| 2| 4| 3| 2| 3| 3|            |
                                           | 2| 8| 6| 2| 2| 4| 9| 2| 2| 2| 2| 2| 2| 8| 6| 7| 2| 8| 2| 6| 3| 2| 1| 2| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    0.5 PPM                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Angiectasis, Multifocal              |                               3                                          |      1  3.0|
      Fat, Inflammation, Chronic           |                               2                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |                   1  1     2              2           1     1  1        1|     21  1.2|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   2        |
      Abscess                              |                                                                          |      1  4.0|
      Dysplasia                            |                                                                          |      2  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                 +                        |   1        |
      Inflammation, Chronic                |                                                 2                        |      1  2.0|
      Mesenteric Artery, Inflammation,     |                                                                          |            |
           Chronic                         |                                                 3                        |      1  3.0|
      Mesenteric Artery, Thrombosis        |                                                 4                        |      1  4.0|
      Renal Artery, Inflammation, Chronic, |                                                                          |            |
           Multifocal                      |                                                 4                        |      1  4.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       |                1                                2                        |      2  1.5|
      Inflammation, Chronic, Focal         |                                                                          |      1  1.0|
      Aortic Valve, Inflammation, Chronic  |                                                                          |            |
          Active, Focal                    |                                                                2         |      1  2.0|
      Epicardium, Hyperplasia, Focal       |    2                                                                     |      1  2.0|
      Mitral Valve, Inflammation, Focal,   |                                                                          |            |
           Subacute                        |                                                                          |      1  3.0|
      Perivascular, Granuloma              |          3                                                               |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Subcapsular, Hyperplasia, Focal      |                                                                          |      4  2.3|
      Subcapsular, Hyperplasia, Multifocal | 2  3  2  1  1  1     1                    1        2           2  1  2  2|     27  1.6|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Cyst                                 |                                  3                                       |      1  3.0|
      Hyperplasia, Focal                   |                   2                    2                                 |      7  2.1|
      Hyperplasia, Multifocal              |                                              2                           |      3  2.3|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  66                                                               
NTP Experiment-Test: 05072-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:26:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 5| 7| 6| 6| 7| 7| 7| 7| 7| 6| 6| 5| 5| 6| 6| 7| 4| 6| 7| 6| 7| 7|            |
                             DAY ON TEST   | 3| 7| 0| 9| 3| 8| 2| 3| 3| 3| 3| 3| 2| 8| 6| 8| 9| 7| 3| 2| 4| 3| 2| 3| 3|            |
                                           | 2| 8| 6| 2| 2| 4| 9| 2| 2| 2| 2| 2| 2| 8| 6| 7| 2| 8| 2| 6| 3| 2| 1| 2| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    0.5 PPM                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Hypertrophy, Focal                   |                               2                                          |      3  2.3|
      Hypertrophy, Multifocal              |                      3                                                  1|      3  2.3|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +|  43        |
      Hyperplasia, Focal                   |                                                                          |      1  2.0|
      Hyperplasia, Multifocal              |                                                 3                        |      1  3.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia, Focal                   |                                                             2        2   |      2  2.0|
      Hyperplasia, Multifocal              |          2        2        2           3           1  2                  |      7  2.3|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  +  M  +  +  M  +  +  +  +  M  +  +  M  +  +  +  +  +  +  M  M  +  +  M|  30        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Pars Distalis, Cyst                  |                                                                          |      1  2.0|
      Pars Distalis, Cyst, Multiple        |                               2                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Follicle, Cyst                       |                                                                      1   |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                           +                              |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Granuloma                            |                   3                                                      |      1  3.0|
      Granuloma Sperm                      |                                                                      2   |      1  2.0|
                                            __________________________________________________________________________|____________|
   Penis                                   |                                              +                           |   1        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                   +                       +     +                        |   4        |
      Abscess                              |                   4                             4                        |      2  4.0|
      Ectasia                              |                                           4                              |      1  4.0|
      Inflammation, Chronic                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Ectasia, Multifocal                  |                                                                          |      1  3.0|
      Granuloma                            |                                                                          |      1  4.0|
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |                                                                          |      1  2.0|
      Inflammation, Chronic Active         |          2                                                               |      1  2.0|
      Serosa, Inflammation, Acute, Focal,  |                                                                          |            |
           Suppurative                     |                                                          3               |      1  3.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ectasia                              |          4                                                               |      3  4.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Interstitial Cell, Hyperplasia,      |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  67                                                               
NTP Experiment-Test: 05072-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:26:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 5| 7| 6| 6| 7| 7| 7| 7| 7| 6| 6| 5| 5| 6| 6| 7| 4| 6| 7| 6| 7| 7|            |
                             DAY ON TEST   | 3| 7| 0| 9| 3| 8| 2| 3| 3| 3| 3| 3| 2| 8| 6| 8| 9| 7| 3| 2| 4| 3| 2| 3| 3|            |
                                           | 2| 8| 6| 2| 2| 4| 9| 2| 2| 2| 2| 2| 2| 8| 6| 7| 2| 8| 2| 6| 3| 2| 1| 2| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    0.5 PPM                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
          Diffuse                          |                                                                          |      2  2.0|
      Seminiferous Tubule, Atrophy,        |                                                                          |            |
          Multifocal                       |             2        3                                3     2  2     2   |      8  2.5|
      Seminiferous Tubule, Degeneration,   |                                                                          |            |
           Multifocal                      |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Metaplasia, Focal, Osseous           |                                  2                                       |      1  2.0|
      Myeloid Cell, Hyperplasia            |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inguinal, Hyperplasia                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  M  +  +  +  +  M  +  +  +  +  +  +  +     +  +  M  M  +  +  +  +  +  +|  39        |
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
      Pigmentation, Hemosiderin            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hematopoietic Cell Proliferation     |                                           3  3              3            |      7  2.6|
      Hemorrhage, Acute                    |             2  3              3     3     3  2  4     2     2  2  2  2  2|     25  2.4|
      Hemorrhage, Subacute                 |                                                                          |      3  1.7|
      Hyperplasia, Lymphoid                |                                                                         1|      4  2.3|
      Pigmentation, Hemosiderin            |          2                                                               |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hematopoietic Cell Proliferation     |          2        3           2              2  3        4  4            |     10  2.7|
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  M  M  +  +  +  +  +  M  +  +  M  M  +  +  M  +  +  +  +  +|  38        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  M  M  +  M  M  M  M  M  M  M  M  M  +  M  M  M  M  M  +  M  M|   3        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Prepuce, Inflammation, Chronic Active|          4                                                               |      1  4.0|
      Prepuce, Ulcer                       |          4                                                               |      1  4.0|
      Subcutaneous Tissue, Edema           |                                                          2               |      1  2.0|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Focal, Subacute                 |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Sternum, Developmental Malformation  |                         3                                                |      2  3.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  68                                                               
NTP Experiment-Test: 05072-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:26:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 5| 7| 6| 6| 7| 7| 7| 7| 7| 6| 6| 5| 5| 6| 6| 7| 4| 6| 7| 6| 7| 7|            |
                             DAY ON TEST   | 3| 7| 0| 9| 3| 8| 2| 3| 3| 3| 3| 3| 2| 8| 6| 8| 9| 7| 3| 2| 4| 3| 2| 3| 3|            |
                                           | 2| 8| 6| 2| 2| 4| 9| 2| 2| 2| 2| 2| 2| 8| 6| 7| 2| 8| 2| 6| 3| 2| 1| 2| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    0.5 PPM                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mineralization, Multifocal           | 2     2     2     3  3     3     3              2        1  1  2  2  2  1|     29  2.1|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Inflammation, Chronic                |       1                                                                  |      1  1.0|
      Inflammation, Chronic Active         |                                                             1            |      2  1.5|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage, Acute                    |                                           4                              |      1  4.0|
      Hemorrhage, Subacute                 |                                                                          |      1  2.0|
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |                                                                      2   |      1  2.0|
      Thrombosis                           |                                                                          |      1  2.0|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |       1                       2                 2              1     3  4|     13  2.2|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Multifocal                      |          2           3     2           2              1                  |      8  1.8|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Diffuse, Histiocyte             |                               2                                          |      1  2.0|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Multifocal, Histiocyte          |                2                                                         |      4  2.3|
      Artery, Thrombosis, Multifocal       |                                                    4                     |      1  4.0|
      Bronchiole, Hyperplasia, Focal       |                                                                1         |      4  1.8|
      Bronchiole, Hyperplasia, Multifocal  |          2                             2              1           2      |      5  1.6|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lumen, Exudate                       |                1                                                         |      1  1.0|
      Mucosa, Inflammation, Chronic Active |                                              1                           |      2  1.5|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Chronic Active                  |                                                             1            |      1  1.0|
      Respiratory Epithelium, Hyperplasia  |                         1           1                       1            |      6  1.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
      Atrophy                              |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  69                                                               
NTP Experiment-Test: 05072-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:26:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 5| 7| 6| 6| 7| 7| 7| 7| 7| 6| 6| 5| 5| 6| 6| 7| 4| 6| 7| 6| 7| 7|            |
                             DAY ON TEST   | 3| 7| 0| 9| 3| 8| 2| 3| 3| 3| 3| 3| 2| 8| 6| 8| 9| 7| 3| 2| 4| 3| 2| 3| 3|            |
                                           | 2| 8| 6| 2| 2| 4| 9| 2| 2| 2| 2| 2| 2| 8| 6| 7| 2| 8| 2| 6| 3| 2| 1| 2| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    0.5 PPM                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hydronephrosis                       |                                                                          |      3  2.0|
      Infarct                              |                                     1                                    |      1  1.0|
      Infiltration Cellular, Plasma Cell   |                                                                          |      1  2.0|
      Infiltration Cellular, Lymphocyte    |    1                          1  1                    1     4  3         |     15  1.5|
      Nephropathy, Chronic                 |                   1              1                                      1|      5  1.0|
      Cortex, Cyst                         |                                                                      2   |      1  2.0|
      Pelvis, Inflammation, Acute          |          2                                                               |      1  2.0|
      Renal Tubule, Cytoplasmic Alteration,|                                                                          |            |
           Multifocal                      |                                                          2               |      1  2.0|
      Renal Tubule, Hyperplasia, Atypical, |                                                                          |            |
           Focal                           |       2                          1                                       |      2  1.5|
      Renal Tubule, Hyperplasia, Multifocal|                2                                      1                  |      2  1.5|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|  47        |
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |    2                                                                     |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  70                                                               
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