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TR 386 Mouse Pathology Tables

NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11 
LAB: Midwest Research Inst                                     DATE: 09/09/94   
EXP: 05072                    TETRANITROMETHANE                TIME: 03:28:53   
TEST: 02              CAGES FROM 0000 TO LAST CAGE             PAGE:   1        
TEST TYPE: CHRONIC          ROUTE: RESPIRATORY EXPOSURE WHOLE  NTP C#: 55947    
CONT: N01ES38042                                               CAS: 509-14-8    
PATHOLOGIST: M. STEDHAM                                                         
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NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11
LAB: Midwest Research Inst                                     DATE: 09/09/94  
EXP: 05072                    TETRANITROMETHANE                TIME: 03:28:53  
TEST: 02              CAGES FROM 0000 TO LAST CAGE                             
TEST TYPE: CHRONIC          ROUTE: RESPIRATORY EXPOSURE WHOLE  NTP C#: 55947   
CONT: N01ES38042                                               CAS: 509-14-8   
PATHOLOGIST: M. STEDHAM                                                        

                                 TETRANITROMETHANE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 729 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = CONTROL                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 13     CENSORED DEATHS 0    TERMINAL 37        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      504   629   639   646   654   654   662   662   674   677                 |
 |      690   691   698                                                           |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 0.5 PPM                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 22     CENSORED DEATHS 2    TERMINAL 26        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      426   534   566   580   587   588   592   621   622   629                 |
 |      643   643   657   657   657   678   678   678   684   688                 |
 |      692   706                                                                 |
 |  CENSORED DEATHS                                                               |
 |      30    48                                                                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 2 PPM                                    |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 35     CENSORED DEATHS 0    TERMINAL 15        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      145   299   376   485   513   514   537   546   553   555                 |
 |      560   565   571   588   591   604   614   614   625   627                 |
 |      642   642   649   652   654   659   671   684   691   710                 |
 |      714   717   717   718   722                                               |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================

                                 TETRANITROMETHANE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 729 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   729 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |CONTROL    |   100.0 100.0 100.0 100.0 100.0 100.0  98.0  98.0  84.0  74.0      |
 |           |                                                                    |
 |           |                                                                    |
 |0.5 PPM    |   100.0 100.0 100.0 100.0 100.0  97.9  95.8  85.4  68.8  54.2      |
 |           |                                                                    |
 |           |                                                                    |
 |2 PPM      |   100.0  98.0  98.0  96.0  94.0  92.0  86.0  68.0  48.0  30.0      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                    DOSE                        |
 |                                                                                |
 |                                CONTROL          0.5 PPM          2 PPM         |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       74.0%            54.2%            30.0%         |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P<0.001          P=0.046          P<0.001       |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       652.3            627.5            592.1         |
 |NATURAL DEATHS (C)      |       (13.6)           (13.8)           (20.6)        |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       709.1            656.8            633.2         |
 |(STANDARD ERROR)        |       ( 5.9)           (20.3)           (17.0)        |
 |                        |                                                       |
 ==================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                                 TETRANITROMETHANE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 729 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = CONTROL                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 17     CENSORED DEATHS 2    TERMINAL 31        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      214   544   563   590   603   605   606   613   619   619                 |
 |      627   629   642   642   655   657   704                                   |
 |  CENSORED DEATHS                                                               |
 |      382   480                                                                 |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 0.5 PPM                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 21     CENSORED DEATHS 1    TERMINAL 28        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      263   335   389   524   576   592   601   601   612   665                 |
 |      666   692   692   693   699   701   703   706   715   716                 |
 |      718                                                                       |
 |  CENSORED DEATHS                                                               |
 |      128                                                                       |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 2 PPM                                    |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 26     CENSORED DEATHS 0    TERMINAL 24        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      261   444   446   520   521   535   546   565   612   633                 |
 |      645   666   673   674   681   684   686   687   698   698                 |
 |      703   703   703   705   714   726                                         |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================

                                 TETRANITROMETHANE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 729 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   729 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |CONTROL    |   100.0 100.0  98.0  98.0  98.0  98.0  95.9  87.6  66.7  64.6      |
 |           |                                                                    |
 |           |                                                                    |
 |0.5 PPM    |   100.0 100.0  98.0  95.9  93.9  93.9  91.8  83.7  79.6  57.1      |
 |           |                                                                    |
 |           |                                                                    |
 |2 PPM      |   100.0 100.0  98.0  98.0  98.0  94.0  88.0  84.0  78.0  48.0      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                    DOSE                        |
 |                                                                                |
 |                                CONTROL          0.5 PPM          2 PPM         |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       64.6%            57.1%            48.0%         |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=0.190          P=0.703          P=0.239       |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       596.0            612.3            620.3         |
 |NATURAL DEATHS (C)      |       (25.5)           (28.8)           (21.9)        |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       671.9            668.0            672.5         |
 |(STANDARD ERROR)        |       (14.2)           (18.2)           (13.7)        |
 |                        |                                                       |
 ==================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                                                         TETRANITROMETHANE
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        CONTROL          = 1
                                                        0.5 PPM          = 2
                                                        2 PPM            = 3

------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  100 + 1                      3                                           2           1
      |                        3                       3                   2           1     2             1
      |                                                3           3                 3       2   2 2       1 11
      |                                                                              3   3         22         11
   90 +
      |                                                                                  3   3      2 2        1 1
P     |                                                                                      333      2   2      1 1
E     |                                                                                        33         22
R  80 +                                                                                                    2 2     1 1
C     |                                                                                         33
E     |                                                                                          33 3        2 2     11     1
N     |                                                                                             3 3
T  70 +                                                                                               3 3      2   2
      |                                                                                                 33
S     |                                                                                                  3 3
U     |                                                                                                            22
R  60 +                                                                                                    3 3      22
V     |                                                                                                              2 2
I     |                                                                                                      333       2    2
V     |
A  50 +                                                                                                        3 3
L     |                                                                                                          33
      |                                                                                                           3 33
      |                                                                                                              3  3
   40 +
      |                                                                                                                 33
      |
      |                                                                                                                  33
   30 +                                                                                                                   3 3
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 10 obs hidden.

                                                         TETRANITROMETHANE
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        CONTROL          = 1
                                                        0.5 PPM          = 2
                                                        2 PPM            = 3

----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  100 + 1                                 1       2
      |                                   1       2          2                3               1
      |                                                      2        2       3            2  1  1    1
      |                                                                                    2       2  1 1
P  90 +                                                                                    3 3     2  2
E     |                                                                                      33       22
R     |                                                                                       3  3      11
C     |                                                                                                2 11 3    2
E  80 +                                                                                                   113 3  22
N     |                                                                                                       3   2  2
T     |                                                                                                    1 1    33
      |                                                                                                            3322
S  70 +                                                                                                      1 1      22
U     |                                                                                                        1       1
R     |                                                                                                             3331    1
V     |                                                                                                                2 2
I  60 +                                                                                                               33
V     |                                                                                                                  2  2
A     |
L     |                                                                                                                33
   50 +                                                                                                                 3 3
      |                                                                                                                   3 3
      |
      |
   40 +
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 14 obs hidden.

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