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TR 386 Rat Pathology Tables


                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                         TETRANITROMETHANE


NTP Experiment-Test: 05072-01                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 09/09/94
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 01:16:35




       Facility:  Midwest Research Institute

       Chemical CAS #:  509-14-8

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05072-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 09/09/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 01:16:35  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      2 PPM        5 PPM                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Natural Death                                      6            3            8                                                  
    Moribund Sacrifice                                19           13           27                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                25           34           15                                                  
  Animals Examined Microscopically                    50           50           50                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (49)         (48)         (48)                                                
   Intestine Large, Colon                             (50)         (49)         (48)                                                
   Intestine Large, Rectum                            (49)         (49)         (49)                                                
   Intestine Small, Duodenum                          (49)         (49)         (49)                                                
      Leiomyoma                                                                  1 (2%)                                             
   Intestine Small, Ileum                             (46)         (49)         (46)                                                
   Intestine Small, Jejunum                           (44)         (47)         (43)                                                
   Liver                                              (50)         (50)         (50)                                                
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                  1 (2%)                                             
      Hepatocellular Carcinoma                                                   1 (2%)                                             
      Hepatocellular Adenoma                           1 (2%)       1 (2%)                                                          
      Sarcoma, Metastatic, Lung                                                  1 (2%)                                             
   Mesentery                                          (4)          (6)          (8)                                                 
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                  1 (13%)                                            
      Sarcoma, Metastatic, Uncertain Primary Site                                1 (13%)                                            
      Sarcoma, Metastatic, Uterus                                                1 (13%)                                            
   Pancreas                                           (50)         (50)         (49)                                                
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                  3 (6%)                                             
      Mixed Tumor Malignant, Metastatic, Lung                                    1 (2%)                                             
      Sarcoma, Metastatic, Lung                                                  1 (2%)                                             
   Salivary Glands                                    (50)         (50)         (50)                                                
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                  1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   2                                                               
NTP Experiment-Test: 05072-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 09/09/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 01:16:35  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      2 PPM        5 PPM                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)                                                
      Alveolar/Bronchiolar Carcinoma, Multiple,                                                                                     
           Metastatic, Lung                                                      1 (2%)                                             
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                  3 (6%)                                             
      Sarcoma, Multiple, Metastatic, Lung                                        1 (2%)                                             
      Epicardium, Carcinoma, Metastatic, Lung                                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (50)         (50)         (50)                                                
   Adrenal Gland, Cortex                              (50)         (49)         (50)                                                
      Adenoma                                                                    3 (6%)                                             
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                  5 (10%)                                            
      Carcinoma                                                                  1 (2%)                                             
      Carcinoma, Metastatic, Lung                                                1 (2%)                                             
      Medulla, Alveolar/Bronchiolar Carcinoma,                                                                                      
           Metastatic, Lung                                                      2 (4%)                                             
   Adrenal Gland, Medulla                             (43)         (48)         (45)                                                
      Pheochromocytoma Complex                                                   1 (2%)                                             
      Pheochromocytoma Benign                          2 (5%)       3 (6%)       2 (4%)                                             
      Sarcoma, Metastatic, Lung                                                  1 (2%)                                             
      Bilateral, Pheochromocytoma Benign                            1 (2%)       1 (2%)                                             
   Islets, Pancreatic                                 (50)         (50)         (49)                                                
      Carcinoma                                                                  1 (2%)                                             
   Pituitary Gland                                    (50)         (48)         (50)                                                
      Pars Distalis, Adenoma                          27 (54%)     27 (56%)     24 (48%)                                            
      Pars Distalis, Adenoma, Two                      1 (2%)       2 (4%)       1 (2%)                                             
      Pars Distalis, Alveolar/Bronchiolar                                                                                           
          Carcinoma, Metastatic, Lung                                            1 (2%)                                             
      Pars Distalis, Carcinoma                         1 (2%)       2 (4%)                                                          
      Pars Intermedia, Adenoma                                                   1 (2%)                                             
   Thyroid Gland                                      (49)         (50)         (50)                                                
      C-Cell, Adenoma                                  3 (6%)       6 (12%)      4 (8%)                                             
      C-Cell, Carcinoma                                3 (6%)       2 (4%)       1 (2%)                                             
      Follicular Cell, Adenoma                                                   1 (2%)                                             
      Follicular Cell, Carcinoma                                                 1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   3                                                               
NTP Experiment-Test: 05072-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 09/09/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 01:16:35  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      2 PPM        5 PPM                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                                                   (3)                                                 
      Alveolar/Bronchiolar Carcinoma, Multiple,                                                                                     
           Metastatic, Lung                                                      1 (33%)                                            
      Sarcoma, Metastatic, Uncertain Primary Site                                1 (33%)                                            
      Squamous Cell Carcinoma, Metastatic, Lung                                  1 (33%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (47)         (48)         (44)                                                
      Adenoma                                          1 (2%)       4 (8%)                                                          
      Carcinoma                                        2 (4%)       1 (2%)                                                          
   Ovary                                              (50)         (50)         (48)                                                
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                  5 (10%)                                            
      Bilateral, Carcinoma, Metastatic, Lung                                     1 (2%)                                             
      Bilateral, Sarcoma, Metastatic, Lung                                       1 (2%)                                             
   Uterus                                             (50)         (50)         (50)                                                
      Deciduoma Benign                                              1 (2%)                                                          
      Polyp Stromal                                    9 (18%)      8 (16%)      5 (10%)                                            
      Polyp Stromal, Two                                            1 (2%)                                                          
      Sarcoma                                                                    2 (4%)                                             
      Sarcoma Stromal                                               1 (2%)                                                          
      Bilateral, Polyp Stromal                         2 (4%)       3 (6%)                                                          
   Vagina                                             (2)          (1)                                                              
      Schwannoma Malignant, Metastatic, Urinary                                                                                     
          Bladder                                                   1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (48)         (50)         (50)                                                
   Lymph Node                                         (50)         (50)         (50)                                                
      Sarcoma, Metastatic, Lung                                                  1 (2%)                                             
      Mediastinal, Alveolar/Bronchiolar Carcinoma,                                                                                  
           Metastatic, Lung                                                      5 (10%)                                            
      Mediastinal, Carcinoma, Metastatic, Lung                                   1 (2%)                                             
      Serosa, Mediastinal, Sarcoma, Metastatic,                                                                                     
           Uncertain Primary Site                                                1 (2%)                                             
   Lymph Node, Mandibular                             (49)         (50)         (49)                                                
   Lymph Node, Mesenteric                             (47)         (49)         (49)                                                
   Spleen                                             (50)         (50)         (50)                                                
      Squamous Cell Carcinoma, Metastatic, Lung                                  1 (2%)                                             
   Thymus                                             (48)         (46)         (42)                                                
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                  4 (10%)                                            
                                                             Page   4                                                               
NTP Experiment-Test: 05072-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 09/09/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 01:16:35  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      2 PPM        5 PPM                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - cont                                                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (48)         (50)         (50)                                                
      Adenocarcinoma                                                1 (2%)                                                          
      Adenoma                                                                    1 (2%)                                             
      Fibroadenoma                                     7 (15%)     11 (22%)      4 (8%)                                             
      Fibroadenoma, Two                                1 (2%)       1 (2%)       2 (4%)                                             
   Skin                                               (50)         (50)         (50)                                                
      Basal Cell Adenoma                                            1 (2%)                                                          
      Basosquamous Tumor Malignant                                  1 (2%)                                                          
      Keratoacanthoma                                  1 (2%)                    1 (2%)                                             
      Squamous Cell Papilloma                                       2 (4%)       1 (2%)                                             
      Subcutaneous Tissue, Alveolar/Bronchiolar                                                                                     
          Carcinoma, Metastatic                                                  1 (2%)                                             
      Subcutaneous Tissue, Alveolar/Bronchiolar                                                                                     
          Carcinoma, Metastatic, Lung                                            1 (2%)                                             
      Subcutaneous Tissue, Fibroma                                  1 (2%)       1 (2%)                                             
      Subcutaneous Tissue, Fibrosarcoma                1 (2%)                                                                       
      Subcutaneous Tissue, Sarcoma                     1 (2%)                                                                       
      Vulva, Papilloma                                 1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)                                                
      Astrocytoma Benign                               1 (2%)                                                                       
      Astrocytoma Malignant                                                      2 (4%)                                             
      Cerebellum, Meningioma Malignant                 1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)                                                
      Alveolar/Bronchiolar Adenoma                                  6 (12%)      3 (6%)                                             
      Alveolar/Bronchiolar Carcinoma                               11 (22%)      3 (6%)                                             
      Alveolar/Bronchiolar Carcinoma, Multiple                      1 (2%)      44 (88%)                                            
      Alveolar/Bronchiolar Carcinoma, Two                           7 (14%)      3 (6%)                                             
      Chordoma, Metastatic, Uncertain Primary Site                  1 (2%)                                                          
      Mixed Tumor Malignant, Multiple                                            1 (2%)                                             
      Osteosarcoma, Metastatic, Uncertain Primary                                                                                   
                                                             Page   5                                                               
NTP Experiment-Test: 05072-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 09/09/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 01:16:35  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      2 PPM        5 PPM                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - cont                                                                                                           
          Site                                                                   1 (2%)                                             
      Sarcoma, Multiple                                                          1 (2%)                                             
      Squamous Cell Carcinoma                                       1 (2%)      10 (20%)                                            
      Squamous Cell Carcinoma, Multiple                                          2 (4%)                                             
      Mediastinum, Carcinoma, Metastatic, Lung                                   1 (2%)                                             
      Mediastinum, Squamous Cell Carcinoma,                                                                                         
          Metastatic, Lung                                                       1 (2%)                                             
      Pleura, Mediastinum, Sarcoma, Metastatic,                                                                                     
           Uncertain Primary Site                                                1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)                                                
      Alveolar/Bronchiolar Carcinoma, Multiple,                                                                                     
           Metastatic, Lung                                                      2 (4%)                                             
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                  7 (14%)                                            
      Carcinoma, Metastatic, Lung                                                1 (2%)                                             
      Osteosarcoma, Metastatic, Uncertain Primary                                                                                   
          Site                                                                   1 (2%)                                             
      Sarcoma, Metastatic, Lung                                                  2 (4%)                                             
   Urinary Bladder                                    (49)         (50)         (48)                                                
      Schwannoma Malignant                                          1 (2%)                                                          
      Transitional Epithelium, Papilloma                            1 (2%)                                                          
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)                                                
      Leukemia                                                                   1 (2%)                                             
      Leukemia Mononuclear                            18 (36%)     10 (20%)      6 (12%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   6                                                               
NTP Experiment-Test: 05072-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 09/09/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 01:16:35  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      2 PPM        5 PPM                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            47          49          50                                                   
     Total Primary Neoplasms                           84         119         137                                                   
                                                                                                                                    
   Total Animals with Benign Neoplasms                 37          42          37                                                   
     Total Benign Neoplasms                            57          80          56                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms              24          31          50                                                   
     Total Malignant Neoplasms                         27          39          81                                                   
                                                                                                                                    
   Total Animals with Metastatic Neoplasms                          2          20                                                   
     Total Metastatic Neoplasm                                      2          69                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms                           1           2                                                   
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   7                                                               
NTP Experiment-Test: 05072-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 09/09/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 01:16:35  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      2 PPM        5 PPM                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                27           25           39                                                  
    Natural Death                                      5            8            7                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                18           17            4                                                  
  Animals Examined Microscopically                    50           50           50                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (45)         (49)         (49)                                                
   Intestine Large, Colon                             (49)         (47)         (49)                                                
   Intestine Large, Rectum                            (46)         (48)         (48)                                                
   Intestine Small, Duodenum                          (48)         (49)         (48)                                                
      Adenocarcinoma                                                1 (2%)                                                          
   Intestine Small, Ileum                             (46)         (45)         (46)                                                
      Peyer's Patch, Fibrous Histiocytoma                           1 (2%)                                                          
   Intestine Small, Jejunum                           (47)         (42)         (45)                                                
      Adenocarcinoma                                   1 (2%)                                                                       
      Leiomyosarcoma                                   1 (2%)                                                                       
      Polyp Adenomatous                                                          1 (2%)                                             
   Liver                                              (50)         (50)         (50)                                                
      Adenocarcinoma, Multiple, Metastatic,                                                                                         
          Intestine Small                              1 (2%)                                                                       
      Alveolar/Bronchiolar Carcinoma, Multiple,                                                                                     
           Metastatic, Lung                                         1 (2%)                                                          
      Fibrous Histiocytoma                                          1 (2%)                                                          
      Hepatocellular Carcinoma                         1 (2%)                                                                       
      Hepatocellular Adenoma                                        1 (2%)                                                          
      Histiocytic Sarcoma                                           1 (2%)                                                          
      Neoplastic Nodule                                             1 (2%)                                                          
   Mesentery                                          (4)          (7)          (6)                                                 
      Hemangioma                                       1 (25%)                                                                      
      Histiocytic Sarcoma                                           1 (14%)                                                         
   Pancreas                                           (49)         (48)         (50)                                                
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                  6 (12%)                                            
      Histiocytic Sarcoma                                           1 (2%)                                                          
      Acinus, Adenoma                                                            2 (4%)                                             
   Stomach, Forestomach                               (49)         (49)         (50)                                                
      Histiocytic Sarcoma                                           1 (2%)                                                          
      Squamous Cell Papilloma                                       1 (2%)                                                          
   Tongue                                             (2)          (1)                                                              
                                                             Page   8                                                               
NTP Experiment-Test: 05072-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 09/09/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 01:16:35  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      2 PPM        5 PPM                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - cont                                                                                                            
      Squamous Cell Carcinoma                          1 (50%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (2)          (3)          (2)                                                 
      Aorta, Adventitia, Alveolar/Bronchiolar                                                                                       
          Carcinoma, Metastatic, Lung                                            1 (50%)                                            
   Heart                                              (50)         (50)         (50)                                                
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                     3 (6%)       5 (10%)                                            
      Fibrous Histiocytoma                                          1 (2%)                                                          
      Squamous Cell Carcinoma, Metastatic, Lung                                  2 (4%)                                             
      Epicardium, Carcinoma, Metastatic, Uncertain                                                                                  
          Primary Site                                              1 (2%)                                                          
      Epicardium, Histiocytic Sarcoma                               1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (50)         (50)         (50)                                                
      Capsule, Alveolar/Bronchiolar Carcinoma,                                                                                      
           Metastatic, Lung                                                      1 (2%)                                             
   Adrenal Gland, Cortex                              (50)         (49)         (48)                                                
      Adenoma                                          1 (2%)       1 (2%)                                                          
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                     1 (2%)       3 (6%)                                             
      Medulla, Alveolar/Bronchiolar Carcinoma,                                                                                      
           Metastatic, Lung                                         1 (2%)       1 (2%)                                             
   Adrenal Gland, Medulla                             (46)         (47)         (47)                                                
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                  2 (4%)                                             
      Neuroblastoma Benign                                                       1 (2%)                                             
      Pheochromocytoma Malignant                       1 (2%)       2 (4%)       1 (2%)                                             
      Pheochromocytoma Benign                         12 (26%)     14 (30%)      7 (15%)                                            
      Pheochromocytoma Benign, Multiple                             1 (2%)       3 (6%)                                             
      Bilateral, Pheochromocytoma Benign                            1 (2%)                                                          
   Islets, Pancreatic                                 (49)         (48)         (50)                                                
      Adenoma                                          3 (6%)       5 (10%)      6 (12%)                                            
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                  1 (2%)                                             
      Carcinoma                                        4 (8%)       3 (6%)       4 (8%)                                             
      Carcinoma, Two                                   1 (2%)                                                                       
   Parathyroid Gland                                  (47)         (48)         (43)                                                
      Adenoma                                                       1 (2%)                                                          
   Pituitary Gland                                    (49)         (49)         (48)                                                
      Pars Distalis, Adenoma                          27 (55%)     22 (45%)     16 (33%)                                            
                                                             Page   9                                                               
NTP Experiment-Test: 05072-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 09/09/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 01:16:35  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      2 PPM        5 PPM                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - cont                                                                                                             
      Pars Distalis, Adenoma, Two                      2 (4%)       2 (4%)       2 (4%)                                             
      Pars Distalis, Carcinoma                                      1 (2%)                                                          
      Pars Intermedia, Adenoma                         1 (2%)                                                                       
   Thyroid Gland                                      (49)         (49)         (50)                                                
      C-Cell, Adenoma                                  3 (6%)       1 (2%)       3 (6%)                                             
      C-Cell, Carcinoma                                             1 (2%)                                                          
      Follicular Cell, Carcinoma                       1 (2%)                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                                      (1)          (2)                                                 
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                     1 (100%)     1 (50%)                                            
      Squamous Cell Carcinoma, Metastatic, Lung                                  1 (50%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (49)         (49)         (50)                                                
   Preputial Gland                                    (49)         (48)         (49)                                                
      Carcinoma                                        3 (6%)       2 (4%)       1 (2%)                                             
      Squamous Cell Carcinoma                                       1 (2%)                                                          
   Prostate                                           (48)         (50)         (46)                                                
      Adenocarcinoma                                   1 (2%)                                                                       
      Adenoma                                                       1 (2%)                                                          
   Seminal Vesicle                                    (46)         (47)         (49)                                                
   Testes                                             (50)         (50)         (50)                                                
      Bilateral, Interstitial Cell, Adenoma           19 (38%)     23 (46%)     23 (46%)                                            
      Interstitial Cell, Adenoma                      14 (28%)     15 (30%)     16 (32%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (49)         (49)                                                
   Lymph Node                                         (50)         (50)         (50)                                                
      Mediastinal, Alveolar/Bronchiolar Carcinoma,                                                                                  
           Metastatic, Lung                                         3 (6%)       1 (2%)                                             
      Mediastinal, Histiocytic Sarcoma                              1 (2%)                                                          
   Lymph Node, Mandibular                             (48)         (44)         (46)                                                
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                  1 (2%)                                             
      Fibrous Histiocytoma                                          1 (2%)                                                          
      Mediastinal, Alveolar/Bronchiolar Carcinoma,                                                                                  
           Metastatic, Lung                                                      1 (2%)                                             
   Lymph Node, Mesenteric                             (47)         (48)         (48)                                                
      Histiocytic Sarcoma                                           1 (2%)                                                          
                                                             Page  10                                                               
NTP Experiment-Test: 05072-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 09/09/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 01:16:35  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      2 PPM        5 PPM                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - cont                                                                                                         
   Spleen                                             (50)         (49)         (50)                                                
      Hemangiosarcoma                                                            1 (2%)                                             
   Thymus                                             (36)         (42)         (43)                                                
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                  4 (9%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (43)         (46)         (47)                                                
      Adenoma                                                                    1 (2%)                                             
      Fibroadenoma                                     1 (2%)                    1 (2%)                                             
   Skin                                               (50)         (49)         (50)                                                
      Basal Cell Adenoma                               1 (2%)       1 (2%)                                                          
      Basal Cell Carcinoma                             1 (2%)                                                                       
      Keratoacanthoma                                  2 (4%)       2 (4%)                                                          
      Squamous Cell Papilloma                                       1 (2%)                                                          
      Trichoepithelioma                                             1 (2%)                                                          
      Subcutaneous Tissue, Fibroma                     4 (8%)       2 (4%)       3 (6%)                                             
      Subcutaneous Tissue, Lipoma                                   1 (2%)       1 (2%)                                             
      Subcutaneous Tissue, Sarcoma                                  1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (49)         (49)                                                
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                  1 (2%)                                             
      Periosteum, Femur, Fibrous Histiocytoma                       1 (2%)                                                          
      Right, Femur, Osteosarcoma                                    1 (2%)                                                          
   Skeletal Muscle                                    (1)          (1)                                                              
      Hindlimb, Fibrous Histiocytoma                                1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)                                                
      Granular Cell Tumor Benign                                    1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)                                                
      Alveolar/Bronchiolar Adenoma                     1 (2%)      11 (22%)     11 (22%)                                            
      Alveolar/Bronchiolar Adenoma, Multiple                        2 (4%)                                                          
      Alveolar/Bronchiolar Carcinoma                               18 (36%)      4 (8%)                                             
      Alveolar/Bronchiolar Carcinoma, Multiple                      4 (8%)      35 (70%)                                            
                                                             Page  11                                                               
NTP Experiment-Test: 05072-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 09/09/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 01:16:35  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      2 PPM        5 PPM                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - cont                                                                                                           
      Alveolar/Bronchiolar Carcinoma, Two                           4 (8%)       7 (14%)                                            
      Fibrous Histiocytoma                                          1 (2%)                                                          
      Histiocytic Sarcoma                                           1 (2%)                                                          
      Pheochromocytoma Malignant, Metastatic,                                                                                       
          Adrenal Gland                                1 (2%)                                                                       
      Sarcoma                                                                    1 (2%)                                             
      Squamous Cell Carcinoma                                       1 (2%)      14 (28%)                                            
      Squamous Cell Carcinoma, Two                                               5 (10%)                                            
      Mediastinum, Alveolar/Bronchiolar Carcinoma,                                                                                  
           Metastatic, Lung                                                      1 (2%)                                             
      Pleura, Mediastinum, Alveolar/Bronchiolar                                                                                     
          Carcinoma, Metastatic, Lung                                            1 (2%)                                             
   Nose                                               (48)         (49)         (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Zymbal's Gland                                     (1)          (2)          (1)                                                 
      Adenoma                                                                    1 (100%)                                           
      Carcinoma                                        1 (100%)                                                                     
      Squamous Cell Papilloma                                       2 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)                                                
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                     1 (2%)       5 (10%)                                            
      Squamous Cell Carcinoma, Metastatic, Lung                                  2 (4%)                                             
      Bilateral, Alveolar/Bronchiolar Carcinoma,                                                                                    
           Metastatic, Lung                                         1 (2%)                                                          
      Capsule, Histiocytic Sarcoma                                  1 (2%)                                                          
   Ureter                                             (1)                       (1)                                                 
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                  1 (100%)                                           
   Urinary Bladder                                    (49)         (49)         (48)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)                                                
      Histiocytic Sarcoma                                           1 (2%)                                                          
      Leukemia Mononuclear                            27 (54%)     26 (52%)     22 (44%)                                            
      Lymphoma Malignant                               1 (2%)                                                                       
      Mesothelioma Malignant                           3 (6%)       2 (4%)       5 (10%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  12                                                               
NTP Experiment-Test: 05072-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 09/09/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 01:16:35  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      2 PPM        5 PPM                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            48          49          50                                                   
     Total Primary Neoplasms                          140         190         199                                                   
                                                                                                                                    
   Total Animals with Benign Neoplasms                 47          46          49                                                   
     Total Benign Neoplasms                            92         114          98                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms              38          43          50                                                   
     Total Malignant Neoplasms                         48          76         101                                                   
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              2           6          20                                                   
     Total Metastatic Neoplasm                          2          13          42                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms                           1                                                               
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  13                                                               
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