National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/2093

TR 386 Rat Pathology Tables

NTP Experiment-Test: 05072-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:30:54




       Facility:  Midwest Research Institute

       Chemical CAS #:  509-14-8

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All






































                                                              Page   1

NTP Experiment-Test: 05072-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:30:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 5| 7| 6| 7| 7| 7| 7| 5| 6| 7| 6| 5| 4| 7| 7| 4| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 4| 2| 2| 1| 2| 0| 2| 2| 2| 2| 9| 5| 2| 7| 4| 9| 2| 2| 5| 2| 2| 2| 2| 2|             
                                           | 9| 4| 7| 7| 0| 7| 2| 7| 7| 7| 8| 0| 9| 5| 4| 8| 1| 8| 8| 4| 8| 8| 9| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute, Necrotizing     |                                        4                                 |             
      Parasite Metazoan                    |             X              X                                             |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                      X        X                                          |             
      Artery, Inflammation, Chronic Active,|                                                                          |             
           Focal                           |                                                             4            |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Parasite Metazoan                    |       X              X     X                                         X  X|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  A  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis, Focal                   |    2              2                                         2            |             
      Basophilic Focus                     |                                                                          |             
      Basophilic Focus, Multiple           |       X  X           X        X  X                 X  X     X  X  X  X  X|             
      Basophilic Focus, Two                |                                                                          |             
      Cytoplasmic Alteration, Focal        |                                                             2            |             
      Eosinophilic Focus                   |                                                                          |             
      Fatty Change, Diffuse                |             3                       2        4  4                        |             
      Fatty Change, Focal                  |                      2  4                                                |             
      Fatty Change, Multifocal             |                   2                       2                              |             
      Granuloma, Multifocal                |    2              2  1                                2     1  3     1  2|             
      Hepatodiaphragmatic Nodule           |                      X  X                                                |             
      Inflammation, Chronic Active,        |                                                                          |             
          Multifocal                       |                                                                          |             
      Mitotic Alteration                   |                                           3                              |             
      Mixed Cell Focus                     |                                                    X  X                  |             
      Mixed Cell Focus, Multiple           |                            X                                             |             
      Necrosis, Acute, Focal               |                                                                          |             
      Necrosis, Acute, Multifocal          |                                     2                                    |             
      Necrosis, Focal, Subacute            |    2                                                                     |             
      Vacuolization Cytoplasmic, Multifocal|                            2                                             |             
      Bile Duct, Hyperplasia, Multifocal   |                3  2     1                 2     3                        |             
      Centrilobular, Atrophy, Diffuse      | 3           2                                                            |             
      Centrilobular, Atrophy, Multifocal   |                4                          3                              |             
      Centrilobular, Fatty Change, Diffuse |                                                                          |             
      Periportal, Fatty Change, Diffuse    |                                        2                                 |             
      Periportal, Fatty Change, Multifocal |    2                                                        2            |             
      Periportal, Inflammation, Chronic,   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05072-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:30:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 5| 7| 6| 7| 7| 7| 7| 5| 6| 7| 6| 5| 4| 7| 7| 4| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 4| 2| 2| 1| 2| 0| 2| 2| 2| 2| 9| 5| 2| 7| 4| 9| 2| 2| 5| 2| 2| 2| 2| 2|             
                                           | 9| 4| 7| 7| 0| 7| 2| 7| 7| 7| 8| 0| 9| 5| 4| 8| 1| 8| 8| 4| 8| 8| 9| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
           Multifocal                      |                                                                          |             
      Portal, Inflammation, Chronic,       |                                                                          |             
          Multifocal                       |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                     +                                    |             
      Accessory Spleen                     |                                                                          |             
      Fat, Necrosis, Focal                 |                                     3                                    |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic, Multifocal    |                                                       3                  |             
      Acinus, Atrophy, Diffuse             |                               4                                          |             
      Acinus, Atrophy, Focal               |                                                                          |             
      Acinus, Atrophy, Multifocal          |    1           2  2              2        2           4     3           2|             
      Acinus, Hyperplasia, Focal           |                                                                          |             
      Artery, Inflammation, Chronic Active,|                                                                          |             
           Multifocal                      |                                                             4            |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Duct, Hyperplasia, Focal             |                                                       2                  |             
      Duct, Inflammation, Chronic Active,  |                                                                          |             
           Focal                           |                                                       1                  |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion, Focal                       |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         |                                     2        3                           |             
      Ulcer, Multifocal                    |                                                                          |             
      Ulcer, Single                        |                                                                          |             
      Epithelium, Hyperplasia, Diffuse     |                                              3                           |             
      Epithelium, Hyperplasia, Focal       |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                        1                                 |             
      Inflammation, Chronic Active         |                                     1                                    |             
      Mucosa, Necrosis, Acute, Focal       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |    3  2  2     3  2  2  2  1  2  1  1  1  1           2     3  3  2  2  3|             
      Atrium Left, Thrombosis              |                                                                          |             
      Epicardium, Inflammation, Chronic,   |                                                                          |             
           Focal                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Capsule, Accessory Adrenal Cortical  |                                                                          |             
          Nodule                           |          X                                      X                        |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05072-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:30:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 5| 7| 6| 7| 7| 7| 7| 5| 6| 7| 6| 5| 4| 7| 7| 4| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 4| 2| 2| 1| 2| 0| 2| 2| 2| 2| 9| 5| 2| 7| 4| 9| 2| 2| 5| 2| 2| 2| 2| 2|             
                                           | 9| 4| 7| 7| 0| 7| 2| 7| 7| 7| 8| 0| 9| 5| 4| 8| 1| 8| 8| 4| 8| 8| 9| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Angiectasis, Multifocal              |                                                                          |             
      Degeneration, Diffuse, Fatty         |                                     1           2                        |             
      Degeneration, Fatty, Focal           |                               2     2           2           2        3   |             
      Degeneration, Fatty, Multifocal      |                      3                                                   |             
      Hyperplasia, Focal                   |                            2                 1              1  1        1|             
      Hyperplasia, Multifocal              |       2              1                                                   |             
      Hypertrophy, Focal                   |          2        2                                                     1|             
      Hypertrophy, Multifocal              |                                                    2              2      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  M  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis, Diffuse                    |                                                                1         |             
      Hyperplasia, Focal                   |                                        2                                 |             
      Hyperplasia, Multifocal              |                                                                2         |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                      2                                         2         |             
      Hyperplasia, Multifocal              | 2                                2              2        2               |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +|             
      Hyperplasia, Diffuse                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis, Focal                      |                                              2                           |             
      Pars Distalis, Angiectasis, Focal    |                                                                          |             
      Pars Distalis, Angiectasis,          |                                                                          |             
          Multifocal                       |                         4                                   3            |             
      Pars Distalis, Cyst                  |       2        3                                                         |             
      Pars Distalis, Cyst, Multiple        | 2                                         2                          2   |             
      Pars Distalis, Hyperplasia, Focal    |                                  2                                       |             
      Pars Distalis, Hyperplasia,          |                                                                          |             
          Multifocal                       |                2                                                         |             
      Pars Intermedia, Angiectasis,        |                                                                          |             
          Multifocal                       |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                      1   |             
      Inflammation, Focal, Granulomatous   |                                                                      1   |             
      C-Cell, Hyperplasia, Focal           |                   3                                                      |             
      C-Cell, Hyperplasia                  |                                        1                                 |             
      C-Cell, Hyperplasia, Multifocal      |                4     4  3  2                       1              2     3|             
      Follicular Cell, Hypertrophy, Diffuse|                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                                          |             
      Fibrosis                             |                                                                         2|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05072-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:30:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 5| 7| 6| 7| 7| 7| 7| 5| 6| 7| 6| 5| 4| 7| 7| 4| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 4| 2| 2| 1| 2| 0| 2| 2| 2| 2| 9| 5| 2| 7| 4| 9| 2| 2| 5| 2| 2| 2| 2| 2|             
                                           | 9| 4| 7| 7| 0| 7| 2| 7| 7| 7| 8| 0| 9| 5| 4| 8| 1| 8| 8| 4| 8| 8| 9| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Hyperplasia, Focal                   |                                                       3              3   |             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic Active, Focal  |                                                                          |             
      Inflammation, Granulomatous,         |                                                                          |             
          Multifocal                       |                                                                          |             
      Necrosis, Acute                      |                                                                      4   |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                          2               |             
      Cyst, Multiple                       |                                                       2                  |             
      Dilatation                           |                                                       3                  |             
      Fibrosis, Focal                      |                                                                          |             
      Hyperplasia                          |                                              2                           |             
      Prolapse                             |                                                          X               |             
      Cervix, Dilatation                   |                         3                                                |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Epithelium, Hyperplasia, Multifocal  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Hyperplasia                          | 3              3        2        3  2     3  2  4     3     2  2     2  1|             
      Myelofibrosis, Focal                 |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mediastinal, Hemorrhage              | 3                                                  2     3        2      |             
      Mediastinal, Inflammation, Acute     |                                                                          |             
      Pancreatic, Hemorrhage               |                                                          3               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage, Acute                    |                                                                      2   |             
      Hyperplasia, Lymphoid                |                   2                                                      |             
      Hyperplasia, Plasma Cell             |                                                                          |             
      Inflammation, Chronic Active         |                         2                                                |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage, Acute                    |       1                                                                 2|             
      Hyperplasia, Lymphoid                |                               2                                          |             
      Hyperplasia, Re Cell                 |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                  3     3                                 |             
      Depletion Lymphoid                   |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Pigmentation, Hemosiderin            |                                                          2               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05072-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:30:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 5| 7| 6| 7| 7| 7| 7| 5| 6| 7| 6| 5| 4| 7| 7| 4| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 4| 2| 2| 1| 2| 0| 2| 2| 2| 2| 9| 5| 2| 7| 4| 9| 2| 2| 5| 2| 2| 2| 2| 2|             
                                           | 9| 4| 7| 7| 0| 7| 2| 7| 7| 7| 8| 0| 9| 5| 4| 8| 1| 8| 8| 4| 8| 8| 9| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Depletion Lymphoid                   |                                                                          |             
      Epithelial Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia, Diffuse                     |                   4                                                      |             
      Ectasia, Multifocal                  |    3           1        2  2           2  3     2              2        3|             
      Hyperplasia, Diffuse                 |       2                       1                    1              2      |             
      Hyperplasia, Multifocal              |                3     2                                      1            |             
      Inflammation, Granulomatous,         |                                                                          |             
          Multifocal                       |                                  2                                       |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Epidermis, Hyperplasia, Focal        |                                                                          |             
      Subcutaneous Tissue, Abscess         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |                                                                          |             
      Osteopetrosis                        |                4                                                         |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |    X     X        X                                                     X|             
      Hemorrhage, Multifocal               |             2                       3                                    |             
      Hydrocephalus                        |    2              2                                                      |             
      Choroid Plexus, Hyperplasia, Focal   |                                              3                           |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal, Papillary        |                                                                2         |             
      Inflammation, Chronic                |                         2                                               4|             
      Inflammation, Chronic Active         |                   2                                                      |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                                                          |             
      Artery, Mineralization, Multifocal   |                                                                          |             
      Interstitium, Inflammation, Chronic, |                                                                          |             
           Multifocal                      |                                                                      2   |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         | 2                                                                    1   |             
      Thrombosis, Multifocal               |                                                                          |             
      Mucosa, Inflammation, Chronic Active |                3        3                       1  2  2                 2|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   6                                                               
NTP Experiment-Test: 05072-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:30:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 5| 7| 6| 7| 7| 7| 7| 5| 6| 7| 6| 5| 4| 7| 7| 4| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 4| 2| 2| 1| 2| 0| 2| 2| 2| 2| 9| 5| 2| 7| 4| 9| 2| 2| 5| 2| 2| 2| 2| 2|             
                                           | 9| 4| 7| 7| 0| 7| 2| 7| 7| 7| 8| 0| 9| 5| 4| 8| 1| 8| 8| 4| 8| 8| 9| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Mucosa, Inflammation, Chronic Active,|                                                                          |             
           Suppurative                     | 2                                                                    4   |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Chronic                         | 2  2              3                 1     1                 2            |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Chronic Active                  |                                                       3                  |             
      Olfactory Epithelium, Metaplasia,    |                                                                          |             
           Squamous                        |                2                                                         |             
      Respiratory Epithelium, Hyperplasia  |                2                                                     2   |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                   2                                                     1|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                   +                                                      |             
      Cataract                             |                   3                                                      |             
      Posterior Chamber, Synechia          |                   4                                                      |             
      Retina, Degeneration                 |                   4                                                      |             
      Retina, Dysplasia, Focal             |                                                                          |             
                                            __________________________________________________________________________|             
   Lacrimal Gland                          |                   +                                                      |             
      Ectopic Tissue                       |                                                                          |             
      Inflammation, Chronic                |                   2                                                      |             
      Pigmentation                         |                   4                                                      |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy, Chronic                 | 1  2  3  4  2  2  4  4  3  4  2     1  3  2  2  2  4  3     2  4  3  2  4|             
      Pigmentation, Diffuse                |             3                             2  4  2                    1   |             
      Medulla, Mineralization, Multifocal  |                                                                          |             
      Pelvis, Epithelium, Hyperplasia      |                         2                                                |             
      Pelvis, Epithelium, Mineralization   |                                                             1            |             
      Proximal Convoluted Renal Tubule,    |                                                                          |             
           Necrosis, Acute                 |                4                                                         |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute, Diffuse         |                                                                          |             
      Serosa, Inflammation, Chronic Active |                                                             4            |             
      Transitional Epithelium, Hyperplasia,|                                                                          |             
           Focal                           |                            3                                             |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   7                                                               
NTP Experiment-Test: 05072-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:30:54  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 6| 7| 7| 7| 7| 7| 6| 5| 6| 7| 5| 7| 6| 7| 6| 2| 7| 5| 6| 7| 6| 0| 6|            |
                             DAY ON TEST   | 9| 2| 4| 2| 2| 2| 2| 2| 5| 2| 3| 2| 2| 2| 7| 2| 5| 5| 2| 1| 0| 2| 5| 0| 9|            |
                                           | 5| 9| 6| 9| 9| 9| 9| 9| 7| 0| 8| 7| 5| 7| 3| 7| 8| 1| 7| 3| 6| 7| 9| 8| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Acute, Necrotizing     |                                                                          |      1  4.0|
      Parasite Metazoan                    |                                                                X         |      3     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |          X        X                                            X         |      5     |
      Artery, Inflammation, Chronic Active,|                                                                          |            |
           Focal                           |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Parasite Metazoan                    |             X                                                  X         |      7     |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  46        |
      Inflammation, Chronic Active         |                                              1                           |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  A  A  +  +  +  M|  44        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis, Focal                   |                                                                          |      3  2.0|
      Basophilic Focus                     |    X                                                        X            |      2     |
      Basophilic Focus, Multiple           | X        X  X  X  X  X  X        X     X     X        X        X         |     24     |
      Basophilic Focus, Two                |                                                          X               |      1     |
      Cytoplasmic Alteration, Focal        |                                                                          |      1  2.0|
      Eosinophilic Focus                   |                                     X                                    |      1     |
      Fatty Change, Diffuse                |                         4                                               4|      6  3.5|
      Fatty Change, Focal                  |                                                                          |      2  3.0|
      Fatty Change, Multifocal             |                      1                                                   |      3  1.7|
      Granuloma, Multifocal                | 1     4           2  1           1  2                       2            |     15  1.8|
      Hepatodiaphragmatic Nodule           |                                  X                             X  X      |      5     |
      Inflammation, Chronic Active,        |                                                                          |            |
          Multifocal                       |                               3                                          |      1  3.0|
      Mitotic Alteration                   |                   2                                                      |      2  2.5|
      Mixed Cell Focus                     |                                                                          |      2     |
      Mixed Cell Focus, Multiple           |                                                                          |      1     |
      Necrosis, Acute, Focal               | 1                                                                        |      1  1.0|
      Necrosis, Acute, Multifocal          |             2                                                            |      2  2.0|
      Necrosis, Focal, Subacute            |                                                                          |      1  2.0|
      Vacuolization Cytoplasmic, Multifocal|                                                                          |      1  2.0|
      Bile Duct, Hyperplasia, Multifocal   |       2        1  1        1                    2                        |     10  1.8|
      Centrilobular, Atrophy, Diffuse      |                                                                          |      2  2.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   8                                                               
NTP Experiment-Test: 05072-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:30:54  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 6| 7| 7| 7| 7| 7| 6| 5| 6| 7| 5| 7| 6| 7| 6| 2| 7| 5| 6| 7| 6| 0| 6|            |
                             DAY ON TEST   | 9| 2| 4| 2| 2| 2| 2| 2| 5| 2| 3| 2| 2| 2| 7| 2| 5| 5| 2| 1| 0| 2| 5| 0| 9|            |
                                           | 5| 9| 6| 9| 9| 9| 9| 9| 7| 0| 8| 7| 5| 7| 3| 7| 8| 1| 7| 3| 6| 7| 9| 8| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Centrilobular, Atrophy, Multifocal   |                                                 2                        |      3  3.0|
      Centrilobular, Fatty Change, Diffuse |                                           4     4                 4      |      3  4.0|
      Periportal, Fatty Change, Diffuse    |                                                                          |      1  2.0|
      Periportal, Fatty Change, Multifocal |                                                                          |      2  2.0|
      Periportal, Inflammation, Chronic,   |                                                                          |            |
           Multifocal                      |       4                                                                  |      1  4.0|
      Portal, Inflammation, Chronic,       |                                                                          |            |
          Multifocal                       |                1                                                         |      1  1.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |    +                                      +  +                           |   4        |
      Accessory Spleen                     |    X                                      X                              |      2     |
      Fat, Necrosis, Focal                 |                                              3                           |      2  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic, Multifocal    |                                                                          |      1  3.0|
      Acinus, Atrophy, Diffuse             |                                                                          |      1  4.0|
      Acinus, Atrophy, Focal               |                                     2                                    |      1  2.0|
      Acinus, Atrophy, Multifocal          |          1     2     1                       2                           |     12  2.0|
      Acinus, Hyperplasia, Focal           |                               1                                          |      1  1.0|
      Artery, Inflammation, Chronic Active,|                                                                          |            |
           Multifocal                      |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Duct, Hyperplasia, Focal             |                                                                          |      1  2.0|
      Duct, Inflammation, Chronic Active,  |                                                                          |            |
           Focal                           |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Erosion, Focal                       |                                                 2                        |      1  2.0|
      Inflammation, Chronic                |                                                                   2      |      1  2.0|
      Inflammation, Chronic Active         |                               4     1           2                       2|      6  2.3|
      Ulcer, Multifocal                    |                               3                                          |      1  3.0|
      Ulcer, Single                        |                                     1     2                              |      2  1.5|
      Epithelium, Hyperplasia, Diffuse     |                                           3                              |      2  3.0|
      Epithelium, Hyperplasia, Focal       |                                                 2                       2|      2  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|  48        |
      Erosion                              |                                                                          |      1  1.0|
      Inflammation, Chronic Active         |                                                                          |      1  1.0|
      Mucosa, Necrosis, Acute, Focal       |                                           2                              |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   9                                                               
NTP Experiment-Test: 05072-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:30:54  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 6| 7| 7| 7| 7| 7| 6| 5| 6| 7| 5| 7| 6| 7| 6| 2| 7| 5| 6| 7| 6| 0| 6|            |
                             DAY ON TEST   | 9| 2| 4| 2| 2| 2| 2| 2| 5| 2| 3| 2| 2| 2| 7| 2| 5| 5| 2| 1| 0| 2| 5| 0| 9|            |
                                           | 5| 9| 6| 9| 9| 9| 9| 9| 7| 0| 8| 7| 5| 7| 3| 7| 8| 1| 7| 3| 6| 7| 9| 8| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Cardiomyopathy                       | 1  3  3  3     3  3  3  1     1  1     1     2        2  2     1         |     34  2.0|
      Atrium Left, Thrombosis              |                                                 4                        |      1  4.0|
      Epicardium, Inflammation, Chronic,   |                                                                          |            |
           Focal                           |                                                 2                        |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Capsule, Accessory Adrenal Cortical  |                                                                          |            |
          Nodule                           |                                                                          |      2     |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis, Multifocal              |             3                                                            |      1  3.0|
      Degeneration, Diffuse, Fatty         |                                           2                              |      3  1.7|
      Degeneration, Fatty, Focal           |    1        2     1                       3           2                  |     10  2.0|
      Degeneration, Fatty, Multifocal      |                                                                          |      1  3.0|
      Hyperplasia, Focal                   |       2  2     1     2  2  3                          2        1         |     13  1.6|
      Hyperplasia, Multifocal              |                                                                          |      2  1.5|
      Hypertrophy, Focal                   |                   1                                                      |      4  1.5|
      Hypertrophy, Multifocal              |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  M  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  M  +|  43        |
      Fibrosis, Diffuse                    |                                                                          |      1  1.0|
      Hyperplasia, Focal                   |                                                                          |      1  2.0|
      Hyperplasia, Multifocal              |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Focal                   |                                                                          |      2  2.0|
      Hyperplasia, Multifocal              | 2                                                                        |      5  2.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  M  +|  44        |
      Hyperplasia, Diffuse                 |                               4                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis, Focal                      |                                                                          |      1  2.0|
      Pars Distalis, Angiectasis, Focal    |                                                             4            |      1  4.0|
      Pars Distalis, Angiectasis,          |                                                                          |            |
          Multifocal                       |                   3        3                                             |      4  3.3|
      Pars Distalis, Cyst                  |                2                                      3        3         |      5  2.6|
      Pars Distalis, Cyst, Multiple        |                                  2              2                        |      5  2.0|
      Pars Distalis, Hyperplasia, Focal    |                   3        2                    2                        |      4  2.3|
      Pars Distalis, Hyperplasia,          |                                                                          |            |
          Multifocal                       |                                                                          |      1  2.0|
      Pars Intermedia, Angiectasis,        |                                                                          |            |
          Multifocal                       |                                              3                           |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  10                                                               
NTP Experiment-Test: 05072-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:30:54  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 6| 7| 7| 7| 7| 7| 6| 5| 6| 7| 5| 7| 6| 7| 6| 2| 7| 5| 6| 7| 6| 0| 6|            |
                             DAY ON TEST   | 9| 2| 4| 2| 2| 2| 2| 2| 5| 2| 3| 2| 2| 2| 7| 2| 5| 5| 2| 1| 0| 2| 5| 0| 9|            |
                                           | 5| 9| 6| 9| 9| 9| 9| 9| 7| 0| 8| 7| 5| 7| 3| 7| 8| 1| 7| 3| 6| 7| 9| 8| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|  49        |
      Cyst                                 |                                                                          |      1  1.0|
      Inflammation, Focal, Granulomatous   |                                                                          |      1  1.0|
      C-Cell, Hyperplasia, Focal           | 2                 3                                                      |      3  2.7|
      C-Cell, Hyperplasia                  |                                                                          |      1  1.0|
      C-Cell, Hyperplasia, Multifocal      |          2     2                          2  2                           |     11  2.5|
      Follicular Cell, Hypertrophy, Diffuse|                            2                                             |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|  47        |
      Ectasia                              |                                                 4              2         |      2  3.0|
      Fibrosis                             |                                                                          |      1  2.0|
      Hyperplasia, Focal                   |             3                                                            |      3  3.0|
      Hyperplasia                          |                                           2                              |      1  2.0|
      Inflammation, Chronic Active, Focal  |             2                                                            |      1  2.0|
      Inflammation, Granulomatous,         |                                                                          |            |
          Multifocal                       |    2                                                           2         |      2  2.0|
      Necrosis, Acute                      |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 | X                                                  3           2         |      3  2.5|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                                                          |      1  2.0|
      Cyst, Multiple                       |                                                                          |      1  2.0|
      Dilatation                           |                2                                         4               |      3  3.0|
      Fibrosis, Focal                      |                                                       3                  |      1  3.0|
      Hyperplasia                          |                                                                          |      1  2.0|
      Prolapse                             |                                                                          |      1     |
      Cervix, Dilatation                   |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Vagina                                  |                         +                                         +      |   2        |
      Inflammation, Chronic Active         |                         2                                                |      1  2.0|
      Epithelium, Hyperplasia, Multifocal  |                         2                                                |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M     +  +  +  +  +  +|  48        |
      Atrophy                              |                                                                      3   |      1  3.0|
      Hyperplasia                          |       3  2  3           3  3  3        1  2     2                       2|     23  2.4|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  11                                                               
NTP Experiment-Test: 05072-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:30:54  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 6| 7| 7| 7| 7| 7| 6| 5| 6| 7| 5| 7| 6| 7| 6| 2| 7| 5| 6| 7| 6| 0| 6|            |
                             DAY ON TEST   | 9| 2| 4| 2| 2| 2| 2| 2| 5| 2| 3| 2| 2| 2| 7| 2| 5| 5| 2| 1| 0| 2| 5| 0| 9|            |
                                           | 5| 9| 6| 9| 9| 9| 9| 9| 7| 0| 8| 7| 5| 7| 3| 7| 8| 1| 7| 3| 6| 7| 9| 8| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Myelofibrosis, Focal                 |                                                 1                        |      1  1.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mediastinal, Hemorrhage              | 2     2                                               2                  |      7  2.3|
      Mediastinal, Inflammation, Acute     |                               3                                          |      1  3.0|
      Pancreatic, Hemorrhage               |       2                                   4                             1|      4  2.5|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|  49        |
      Hemorrhage, Acute                    |                                                                          |      1  2.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
      Hyperplasia, Plasma Cell             |                   2     2                                                |      2  2.0|
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|  47        |
      Hemorrhage, Acute                    |       2     3              2              3                              |      6  2.2|
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
      Hyperplasia, Re Cell                 |                                                                      3   |      1  3.0|
      Inflammation, Chronic Active         |                                              1                           |      1  1.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                                                                          |      2  3.0|
      Depletion Lymphoid                   |                                                                      3   |      1  3.0|
      Hematopoietic Cell Proliferation     |                            2  3                                          |      2  2.5|
      Pigmentation, Hemosiderin            | 2  2           2                    2                       2            |      6  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Depletion Lymphoid                   |                                                                      4   |      1  4.0|
      Epithelial Cell, Hyperplasia         |          2                    2        2              2                  |      4  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +|  48        |
      Ectasia, Diffuse                     |                                                                          |      1  4.0|
      Ectasia, Multifocal                  |    2  1  2  4        4  3     2                                          |     16  2.4|
      Hyperplasia, Diffuse                 |                                     2        2  3           2     3     3|     10  2.1|
      Hyperplasia, Multifocal              |                                                                          |      3  2.0|
      Inflammation, Granulomatous,         |                                                                          |            |
          Multifocal                       |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Epidermis, Hyperplasia, Focal        |                            2                                             |      1  2.0|
      Subcutaneous Tissue, Abscess         |                                                                   4      |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|  49        |
      Fibrous Osteodystrophy               |                               3                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  12                                                               
NTP Experiment-Test: 05072-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:30:54  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 6| 7| 7| 7| 7| 7| 6| 5| 6| 7| 5| 7| 6| 7| 6| 2| 7| 5| 6| 7| 6| 0| 6|            |
                             DAY ON TEST   | 9| 2| 4| 2| 2| 2| 2| 2| 5| 2| 3| 2| 2| 2| 7| 2| 5| 5| 2| 1| 0| 2| 5| 0| 9|            |
                                           | 5| 9| 6| 9| 9| 9| 9| 9| 7| 0| 8| 7| 5| 7| 3| 7| 8| 1| 7| 3| 6| 7| 9| 8| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
      Osteopetrosis                        |                                                       2                 2|      3  2.7|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression                          | X     X  X              X           X                       X           X|     11     |
      Hemorrhage, Multifocal               |                                                                          |      2  2.5|
      Hydrocephalus                        | 4                       2           2                                    |      5  2.4|
      Choroid Plexus, Hyperplasia, Focal   |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                      +   |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +|  48        |
      Hyperplasia, Focal, Papillary        |                                                                          |      1  2.0|
      Inflammation, Chronic                |                         2                                         1      |      4  2.3|
      Inflammation, Chronic Active         | 2  2              2           3              2              2            |      7  2.1|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |                                        1                                 |      1  1.0|
      Artery, Mineralization, Multifocal   |                               2                                          |      1  2.0|
      Interstitium, Inflammation, Chronic, |                                                                          |            |
           Multifocal                      |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|  49        |
      Foreign Body                         |                                                                          |      2  1.5|
      Thrombosis, Multifocal               |                                                 3                       2|      2  2.5|
      Mucosa, Inflammation, Chronic Active |    2     1     2     1                                                   |     10  1.9|
      Mucosa, Inflammation, Chronic Active,|                                                                          |            |
           Suppurative                     |                               4                                          |      3  3.3|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Chronic                         |    1           1  1                                                      |      9  1.6|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Chronic Active                  | 3                                            3                           |      3  3.0|
      Olfactory Epithelium, Metaplasia,    |                                                                          |            |
           Squamous                        |                                                                          |      1  2.0|
      Respiratory Epithelium, Hyperplasia  |                      1        1              1                           |      5  1.4|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Chronic                |                                                             1            |      3  1.3|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                             +     +  +   |   4        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  13                                                               
NTP Experiment-Test: 05072-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:30:54  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 6| 7| 7| 7| 7| 7| 6| 5| 6| 7| 5| 7| 6| 7| 6| 2| 7| 5| 6| 7| 6| 0| 6|            |
                             DAY ON TEST   | 9| 2| 4| 2| 2| 2| 2| 2| 5| 2| 3| 2| 2| 2| 7| 2| 5| 5| 2| 1| 0| 2| 5| 0| 9|            |
                                           | 5| 9| 6| 9| 9| 9| 9| 9| 7| 0| 8| 7| 5| 7| 3| 7| 8| 1| 7| 3| 6| 7| 9| 8| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Cataract                             |                                                                   3      |      2  3.0|
      Posterior Chamber, Synechia          |                                                                          |      1  4.0|
      Retina, Degeneration                 |                                                                   4      |      2  4.0|
      Retina, Dysplasia, Focal             |                                                                      3   |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lacrimal Gland                          |                                                                +         |   2        |
      Ectopic Tissue                       |                                                                X         |      1     |
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Pigmentation                         |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Nephropathy, Chronic                 | 2  3     4  1  3  4  4  3     4  4  2     1  2  2     2  3  3  3  1     2|     43  2.7|
      Pigmentation, Diffuse                |                         2                       3                 2     2|      9  2.3|
      Medulla, Mineralization, Multifocal  |                                              1                           |      1  1.0|
      Pelvis, Epithelium, Hyperplasia      |                                                                          |      1  2.0|
      Pelvis, Epithelium, Mineralization   |                                                                          |      1  1.0|
      Proximal Convoluted Renal Tubule,    |                                                                          |            |
           Necrosis, Acute                 |                                                 2                        |      2  3.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|  49        |
      Inflammation, Acute, Diffuse         |                                                                         2|      1  2.0|
      Serosa, Inflammation, Chronic Active |                      3                                                   |      2  3.5|
      Transitional Epithelium, Hyperplasia,|                                                                          |            |
           Focal                           |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  14                                                               
NTP Experiment-Test: 05072-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:30:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 7| 6| 6| 5| 5| 7| 5| 7| 7| 7| 5| 7| 5| 7| 6| 7| 7| 7| 6| 6| 5| 4|             
                             DAY ON TEST   | 1| 1| 7| 0| 9| 5| 7| 1| 2| 9| 2| 1| 2| 2| 2| 4| 2| 2| 2| 2| 0| 3| 8| 7| 9|             
                                           | 6| 4| 0| 2| 6| 8| 0| 2| 1| 0| 8| 7| 8| 0| 8| 5| 8| 6| 2| 8| 0| 3| 8| 6| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    5 PPM                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |    X                                                                     |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                     X        X     X                     |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  A  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Diffuse,      |                                                                          |             
          Lymphocyte                       |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  A  A  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis, Multifocal              |                                                                          |             
      Basophilic Focus                     | X                                   X                                    |             
      Basophilic Focus, Multiple           |    X     X     X              X           X        X     X     X         |             
      Basophilic Focus, Two                |                         X        X              X     X           X      |             
      Fatty Change, Multifocal             | 3           2              3                                   2         |             
      Fibrosis, Multifocal                 | 2                                                                        |             
      Granuloma, Multifocal                | 1     2        1              2        1        2        1              1|             
      Hemorrhage, Acute, Multifocal        |                            4                                             |             
      Hepatodiaphragmatic Nodule           |                                                             X            |             
      Hyperplasia, Nodular                 |                                              1                           |             
      Mitotic Alteration                   |                                                                          |             
      Mixed Cell Focus                     |                                                             X            |             
      Necrosis, Acute, Focal               |                                                                          |             
      Necrosis, Acute, Multifocal          |                                                                          |             
      Bile Duct, Hyperplasia, Multifocal   |                                                                          |             
      Centrilobular, Atrophy, Diffuse      |                                                                          |             
      Centrilobular, Atrophy, Multifocal   |                      2                                                   |             
      Centrilobular, Fatty Change, Diffuse |                      4                                                   |             
      Centrilobular, Necrosis, Acute,      |                                                                          |             
          Diffuse                          |                                                                          |             
      Centrilobular, Necrosis, Acute,      |                                                                          |             
          Multifocal                       |                                                       2                  |             
      Median Lobe, Hepatodiaphragmatic     |                                                                          |             
          Nodule                           |                                                                          |             
      Periportal, Fatty Change, Diffuse    |                                                                          |             
      Periportal, Fatty Change, Multifocal |                                                                         2|             
      Serosa, Inflammation, Multifocal,    |                                                                          |             
           Proliferative                   |                         4                                                |             
                                            __________________________________________________________________________|             
   Mesentery                               |       +                 +                                                |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  15                                                               
NTP Experiment-Test: 05072-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:30:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 7| 6| 6| 5| 5| 7| 5| 7| 7| 7| 5| 7| 5| 7| 6| 7| 7| 7| 6| 6| 5| 4|             
                             DAY ON TEST   | 1| 1| 7| 0| 9| 5| 7| 1| 2| 9| 2| 1| 2| 2| 2| 4| 2| 2| 2| 2| 0| 3| 8| 7| 9|             
                                           | 6| 4| 0| 2| 6| 8| 0| 2| 1| 0| 8| 7| 8| 0| 8| 5| 8| 6| 2| 8| 0| 3| 8| 6| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    5 PPM                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Fat, Necrosis, Focal                 |                                                                          |             
      Fat, Necrosis, Multifocal            |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectopic Tissue                       |                                                                          |             
      Necrosis, Acute, Focal               |                                                             2            |             
      Acinus, Atrophy, Diffuse             |                         4                                                |             
      Acinus, Atrophy, Focal               |                                        2                                 |             
      Acinus, Atrophy                      |                                                       1                  |             
      Acinus, Atrophy, Multifocal          | 1  2                                                           1         |             
      Artery, Inflammation, Chronic Active,|                                                                          |             
           Focal                           |                                     4                                    |             
      Artery, Inflammation, Chronic Active,|                                                                          |             
           Multifocal                      |                   3                                                      |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cytomegaly, Focal                    |                                                                          |             
      Inflammation, Acute, Focal           |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |             3                                                            |             
      Hyperplasia, Basal Cell, Focal       |                                  3                                       |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic Active         |                                                       3              4   |             
      Necrosis, Acute, Focal               |                                                                          |             
      Ulcer, Multifocal                    |                                                                      4   |             
      Ulcer, Single                        |                                                       2                  |             
      Epithelium, Hyperplasia, Diffuse     |                                                       2                  |             
      Epithelium, Hyperplasia, Focal       |                                  3                                       |             
      Epithelium, Hyperplasia, Multifocal  |                                                                   3  3   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |    1  1  1  1  3  2  2        3  1  1     3     3  1  1     2  2  1  1   |             
      Necrosis, Acute, Multifocal          |                                                             2            |             
      Artery, Adventitia, Hyperplasia      |                                                 3                        |             
      Artery, Adventitia, Mineralization,  |                                                                          |             
           Focal                           |                                           2                              |             
      Artery, Epicardium, Thrombosis       |                                                                          |             
      Atrium Left, Embolus, Focal          |                                                                          |             
      Atrium Left, Inflammation, Acute,    |                                                                          |             
           Multifocal                      |                                                                          |             
      Mitral Valve, Degeneration, Mucoid   |                3                                                         |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  16                                                               
NTP Experiment-Test: 05072-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:30:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 7| 6| 6| 5| 5| 7| 5| 7| 7| 7| 5| 7| 5| 7| 6| 7| 7| 7| 6| 6| 5| 4|             
                             DAY ON TEST   | 1| 1| 7| 0| 9| 5| 7| 1| 2| 9| 2| 1| 2| 2| 2| 4| 2| 2| 2| 2| 0| 3| 8| 7| 9|             
                                           | 6| 4| 0| 2| 6| 8| 0| 2| 1| 0| 8| 7| 8| 0| 8| 5| 8| 6| 2| 8| 0| 3| 8| 6| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    5 PPM                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Capsule, Accessory Adrenal Cortical  |                                                                          |             
          Nodule                           |          X                                                               |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |          3                                            3                  |             
      Degeneration, Diffuse, Fatty         |                      2     2                                             |             
      Degeneration, Fatty, Focal           | 1           4           1                 1                 2        1   |             
      Degeneration, Fatty, Multifocal      |                   1                 2                                    |             
      Degeneration, Focal                  |                                                          1               |             
      Hyperplasia, Focal                   |       1                                                                  |             
      Hyperplasia, Multifocal              |                                                                          |             
      Hypertrophy, Focal                   |                                                          3               |             
      Hypertrophy, Multifocal              |                                           1                              |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +     +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                                                   2  1   |             
      Hyperplasia                          |                                                                          |             
      Hyperplasia, Multifocal              |                                                 1                        |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy, Diffuse                     |                         4                                                |             
      Hyperplasia, Multifocal              |          2                                                               |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +|             
      Hyperplasia, Diffuse                 |                                                                          |             
      Hyperplasia, Focal                   |                                                                      1   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis, Focal    |                   3                                                      |             
      Pars Distalis, Angiectasis,          |                                                                          |             
          Multifocal                       |                            4     3                                       |             
      Pars Distalis, Cyst                  | 1                                            4                           |             
      Pars Distalis, Cyst, Multiple        |                                           3                    2     2   |             
      Pars Distalis, Hyperplasia, Focal    |                   2                       2           2              2   |             
      Pars Intermedia, Angiectasis,        |                                                                          |             
          Multifocal                       |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia, Focal           |                                                                          |             
      C-Cell, Hyperplasia, Multifocal      |          2     1        1  2  3           4     2                 1      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |       +                                                     +            |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Abscess                              |                                     4                                    |             
      Ectasia                              |    4                                      2                              |             
      Hyperplasia, Focal                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  17                                                               
NTP Experiment-Test: 05072-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:30:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 7| 6| 6| 5| 5| 7| 5| 7| 7| 7| 5| 7| 5| 7| 6| 7| 7| 7| 6| 6| 5| 4|             
                             DAY ON TEST   | 1| 1| 7| 0| 9| 5| 7| 1| 2| 9| 2| 1| 2| 2| 2| 4| 2| 2| 2| 2| 0| 3| 8| 7| 9|             
                                           | 6| 4| 0| 2| 6| 8| 0| 2| 1| 0| 8| 7| 8| 0| 8| 5| 8| 6| 2| 8| 0| 3| 8| 6| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    5 PPM                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Inflammation, Granulomatous,         |                                                                          |             
          Multifocal                       |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |    3                                            2                 4      |             
      Bilateral, Cyst                      |          X                                                               |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |          3  4                             2                              |             
      Dilatation                           |    4                          3                                          |             
      Hyperplasia                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                         I                                                |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                      4   |             
      Hyperplasia                          |             3  3  3  2           3  2     3     3  2     3  2  4         |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Plasma Cell             |                                                                2         |             
      Mediastinal, Cyst                    |                                                 3        2               |             
      Mediastinal, Hemorrhage              |                   4                 3                 2        3         |             
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |             
      Mediastinal, Hyperplasia             |                                                                          |             
      Pancreatic, Hemorrhage               | 3           4                                                            |             
      Pancreatic, Hyperplasia, Lymphoid    |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage, Acute                    |                                                                2         |             
      Hyperplasia, Lymphoid                |                      3                                                   |             
      Hyperplasia, Plasma Cell             |                                                 3                        |             
      Hyperplasia, Re Cell                 |                                                                          |             
      Inflammation, Chronic Active         |                            3                                         2   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage, Acute                    | 3     3  3                 3                                             |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Hyperplasia, Re Cell                 |                   3  2                                                   |             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Depletion Lymphoid                   |                                                                          |             
      Fibrosis, Focal                      |                                                                          |             
      Fibrosis, Multifocal                 |                                                                2         |             
      Hematopoietic Cell Proliferation     |                2     4     3                       2        3     3  3  4|             
      Hyperplasia, Re Cell                 |                                                 4                        |             
      Pigmentation, Hemosiderin            |                            3  2        1                                 |             
      Capsule, Fibrosis, Multifocal        |                                              2                           |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  M  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                         4|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  18                                                               
NTP Experiment-Test: 05072-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:30:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 7| 6| 6| 5| 5| 7| 5| 7| 7| 7| 5| 7| 5| 7| 6| 7| 7| 7| 6| 6| 5| 4|             
                             DAY ON TEST   | 1| 1| 7| 0| 9| 5| 7| 1| 2| 9| 2| 1| 2| 2| 2| 4| 2| 2| 2| 2| 0| 3| 8| 7| 9|             
                                           | 6| 4| 0| 2| 6| 8| 0| 2| 1| 0| 8| 7| 8| 0| 8| 5| 8| 6| 2| 8| 0| 3| 8| 6| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    5 PPM                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia, Diffuse                     |                            2                                   4         |             
      Ectasia, Multifocal                  |       2  3     1        4        3     4              4     2            |             
      Fibrosis, Focal                      |                                                       4                  |             
      Galactocele                          |                      X                                4                  |             
      Hyperplasia, Diffuse                 |                                     1        2                           |             
      Hyperplasia, Focal                   |                                        4              3                  |             
      Hyperplasia, Multifocal              |                                                                          |             
      Inflammation, Granulomatous,         |                                                                          |             
          Multifocal                       |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                            4                                             |             
      Inflammation, Chronic Active, Focal  |                                                                          |             
      Inflammation, Multifocal, Subacute   |                                                                          |             
      Ulcer                                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Osteopetrosis                        |       2                                                              4  4|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |             X                       X  X                                 |             
      Hydrocephalus                        |             2                          2                                 |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
      Degeneration, Multifocal, Secondary  |                                                                          |             
          Wallerian                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal, Papillary        |                                           1                              |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |       1                                      1                    1      |             
      Inflammation, Chronic Active         |                2                       2              2     2  1         |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage, Acute, Multifocal        |                                                                          |             
      Inflammation, Acute, Multifocal,     |                                                                          |             
           Necrotizing                     |                                                                          |             
      Inflammation, Multifocal,            |                                                                          |             
          Necrotizing, Subacute            |                                                                          |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Multifocal                      | 4  4  2  4  4  4  4  2  4  4  4  2  4  3  4  3  4  4  4  4  4  4  4  4  3|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  19                                                               
NTP Experiment-Test: 05072-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:30:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 7| 6| 6| 5| 5| 7| 5| 7| 7| 7| 5| 7| 5| 7| 6| 7| 7| 7| 6| 6| 5| 4|             
                             DAY ON TEST   | 1| 1| 7| 0| 9| 5| 7| 1| 2| 9| 2| 1| 2| 2| 2| 4| 2| 2| 2| 2| 0| 3| 8| 7| 9|             
                                           | 6| 4| 0| 2| 6| 8| 0| 2| 1| 0| 8| 7| 8| 0| 8| 5| 8| 6| 2| 8| 0| 3| 8| 6| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    5 PPM                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Bronchiole, Hyperplasia, Multifocal  | 4  4  2  4  4  4  4  2  4  4  4  2  4  3  4     4  4  4  4  4  4  4  4  3|             
      Bronchiole, Alveolus, Inflammation,  |                                                                          |             
           Acute, Multifocal, Suppurative  |                   3                                                     4|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Thrombosis, Multifocal               |                                                                          |             
      Mucosa, Erosion, Multifocal          |                                                                          |             
      Mucosa, Inflammation, Acute          |                            2                                             |             
      Mucosa, Inflammation, Chronic        |                                                                          |             
      Mucosa, Inflammation, Chronic Active |          3     2              2  3        4  1        3     4  3  1  3  2|             
      Mucosa, Inflammation, Chronic Active,|                                                                          |             
           Suppurative                     |             4     4  3  4                                                |             
      Mucosa, Ulcer                        |                                                       2                  |             
      Mucosa, Ulcer, Multifocal            |                                                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Chronic                         |                                              3                           |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Chronic Active                  |                      2                                                   |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Chronic Active, Suppurative     |                                                                          |             
      Olfactory Epithelium, Atrophy        |                                                                          |             
      Respiratory Epithelium, Hyperplasia  |             2     2     1     1  2        3  2  2     1     2  2     1  1|             
      Respiratory Epithelium, Hyperplasia, |                                                                          |             
           Papillary                       |                                                                      2   |             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |                                              2                           |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |             2        2                                                   |             
      Inflammation, Chronic Active         |                   2                    2                                 |             
      Inflammation, Necrotizing, Subacute  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infarct                              |                3                                         1               |             
      Nephropathy, Chronic                 | 2  2  1  1  4     4  1     2  3  1  3  3  4  1  1  2     3  2  1     1   |             
      Pigmentation, Multifocal             |                                  2                                       |             
      Bilateral, Hydronephrosis            |                                                                          |             
      Pelvis, Epithelium, Mineralization   |             2                                                  2         |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  20                                                               
NTP Experiment-Test: 05072-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:30:54  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 7| 6| 6| 7| 7| 7| 5| 7| 7| 7| 7| 6| 5| 5| 7| 5| 7| 6| 4| 7| 6| 7|            |
                             DAY ON TEST   | 2| 8| 4| 2| 9| 6| 2| 1| 2| 6| 2| 2| 2| 2| 9| 6| 8| 2| 3| 2| 9| 7| 2| 6| 2|            |
                                           | 2| 9| 6| 8| 5| 7| 8| 9| 0| 7| 8| 8| 8| 8| 6| 0| 4| 8| 4| 8| 5| 5| 8| 5| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    5 PPM                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|  48        |
      Inflammation, Chronic Active         |                                           2                              |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|  48        |
      Parasite Metazoan                    |                   X           X  X                       X               |      5     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Parasite Metazoan                    |                                                    X              X     X|      6     |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  A  +|  46        |
      Infiltration Cellular, Diffuse,      |                                                                          |            |
          Lymphocyte                       |                                                 3                        |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +     +  +  A  +|  43        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis, Multifocal              |                                                          2               |      1  2.0|
      Basophilic Focus                     |          X           X     X  2                                   X  X   |      8  2.0|
      Basophilic Focus, Multiple           |    X              X              X     X           X  X                 X|     15     |
      Basophilic Focus, Two                |                         X                                   X            |      7     |
      Fatty Change, Multifocal             |                3                    2                                    |      6  2.5|
      Fibrosis, Multifocal                 |                                                                          |      1  2.0|
      Granuloma, Multifocal                | 3              1     1     2     1              2        2              2|     16  1.6|
      Hemorrhage, Acute, Multifocal        |                         2                                                |      2  3.0|
      Hepatodiaphragmatic Nodule           |                      X                             X     X              X|      5     |
      Hyperplasia, Nodular                 |                                                                          |      1  1.0|
      Mitotic Alteration                   |          2                                                               |      1  2.0|
      Mixed Cell Focus                     |                                                                          |      1     |
      Necrosis, Acute, Focal               |                               1                                          |      1  1.0|
      Necrosis, Acute, Multifocal          | 3           3                                                            |      2  3.0|
      Bile Duct, Hyperplasia, Multifocal   | 4                       1     3                                          |      3  2.7|
      Centrilobular, Atrophy, Diffuse      |                                           2                              |      1  2.0|
      Centrilobular, Atrophy, Multifocal   |                               2                                          |      2  2.0|
      Centrilobular, Fatty Change, Diffuse |                                                                2         |      2  3.0|
      Centrilobular, Necrosis, Acute,      |                                                                          |            |
          Diffuse                          |                                                             3            |      1  3.0|
      Centrilobular, Necrosis, Acute,      |                                                                          |            |
          Multifocal                       |                                                                          |      1  2.0|
      Median Lobe, Hepatodiaphragmatic     |                                                                          |            |
          Nodule                           |       X                                                                  |      1     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  21                                                               
NTP Experiment-Test: 05072-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:30:54  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 7| 6| 6| 7| 7| 7| 5| 7| 7| 7| 7| 6| 5| 5| 7| 5| 7| 6| 4| 7| 6| 7|            |
                             DAY ON TEST   | 2| 8| 4| 2| 9| 6| 2| 1| 2| 6| 2| 2| 2| 2| 9| 6| 8| 2| 3| 2| 9| 7| 2| 6| 2|            |
                                           | 2| 9| 6| 8| 5| 7| 8| 9| 0| 7| 8| 8| 8| 8| 6| 0| 4| 8| 4| 8| 5| 5| 8| 5| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    5 PPM                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Periportal, Fatty Change, Diffuse    |                            3                                             |      1  3.0|
      Periportal, Fatty Change, Multifocal |                                              3                           |      2  2.5|
      Serosa, Inflammation, Multifocal,    |                                                                          |            |
           Proliferative                   |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               | +     +  +     +                                +     +                  |   8        |
      Fat, Necrosis, Focal                 |          3                                      4     3                  |      3  3.3|
      Fat, Necrosis, Multifocal            |                4                                                         |      1  4.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Ectopic Tissue                       |                                              X                           |      1     |
      Necrosis, Acute, Focal               |                                                                          |      1  2.0|
      Acinus, Atrophy, Diffuse             | 2                                                                        |      2  3.0|
      Acinus, Atrophy, Focal               |                                                                          |      1  2.0|
      Acinus, Atrophy                      |                                  1                                       |      2  1.0|
      Acinus, Atrophy, Multifocal          |       2                                      1                           |      5  1.4|
      Artery, Inflammation, Chronic Active,|                                                                          |            |
           Focal                           |                                                                          |      1  4.0|
      Artery, Inflammation, Chronic Active,|                                                                          |            |
           Multifocal                      |                                  3                                       |      2  3.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cytomegaly, Focal                    |                               2                                          |      1  2.0|
      Inflammation, Acute, Focal           |                                           3                              |      1  3.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Edema                                |                                                                          |      1  3.0|
      Hyperplasia, Basal Cell, Focal       |                                                                          |      1  3.0|
      Inflammation, Acute                  |                3                                                         |      1  3.0|
      Inflammation, Chronic Active         |                            2        3                                    |      4  3.0|
      Necrosis, Acute, Focal               |                      2                                                   |      1  2.0|
      Ulcer, Multifocal                    |                            2                                             |      2  3.0|
      Ulcer, Single                        |                                                                          |      1  2.0|
      Epithelium, Hyperplasia, Diffuse     |                                     3                                    |      2  2.5|
      Epithelium, Hyperplasia, Focal       |                                                                          |      1  3.0|
      Epithelium, Hyperplasia, Multifocal  |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       |       1  2     2  3  1     1  3  2  1  3        2  2  2  2  1     3  2  2|     36  1.8|
      Necrosis, Acute, Multifocal          |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  22                                                               
NTP Experiment-Test: 05072-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:30:54  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 7| 6| 6| 7| 7| 7| 5| 7| 7| 7| 7| 6| 5| 5| 7| 5| 7| 6| 4| 7| 6| 7|            |
                             DAY ON TEST   | 2| 8| 4| 2| 9| 6| 2| 1| 2| 6| 2| 2| 2| 2| 9| 6| 8| 2| 3| 2| 9| 7| 2| 6| 2|            |
                                           | 2| 9| 6| 8| 5| 7| 8| 9| 0| 7| 8| 8| 8| 8| 6| 0| 4| 8| 4| 8| 5| 5| 8| 5| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    5 PPM                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Artery, Adventitia, Hyperplasia      |                                                                          |      1  3.0|
      Artery, Adventitia, Mineralization,  |                                                                          |            |
           Focal                           |                                                                          |      1  2.0|
      Artery, Epicardium, Thrombosis       |                         3                                                |      1  3.0|
      Atrium Left, Embolus, Focal          |                      4                                                   |      1  4.0|
      Atrium Left, Inflammation, Acute,    |                                                                          |            |
           Multifocal                      |                      3                                                   |      1  3.0|
      Mitral Valve, Degeneration, Mucoid   |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Capsule, Accessory Adrenal Cortical  |                                                                          |            |
          Nodule                           |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                                                                          |      2  3.0|
      Degeneration, Diffuse, Fatty         |                                              2                 2         |      4  2.0|
      Degeneration, Fatty, Focal           |                2  4     2                                                |      9  2.0|
      Degeneration, Fatty, Multifocal      |    2                                2                    2        3  1   |      7  1.9|
      Degeneration, Focal                  |                                                                          |      1  1.0|
      Hyperplasia, Focal                   |          1                             2                                3|      4  1.8|
      Hyperplasia, Multifocal              |                            1                                             |      1  1.0|
      Hypertrophy, Focal                   |                                                                         1|      2  2.0|
      Hypertrophy, Multifocal              |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |    +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
      Hyperplasia, Focal                   |                               1           2                              |      4  1.5|
      Hyperplasia                          |                                                             1            |      1  1.0|
      Hyperplasia, Multifocal              |    2                                                     1               |      3  1.3|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Atrophy, Diffuse                     |                                                                          |      1  4.0|
      Hyperplasia, Multifocal              |    2                                         2                           |      3  2.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  M  +     +  +  +  +  +  +  +  +  +  +  +  +|  45        |
      Hyperplasia, Diffuse                 |                            2                                             |      1  2.0|
      Hyperplasia, Focal                   |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pars Distalis, Angiectasis, Focal    |                                                                          |      1  3.0|
      Pars Distalis, Angiectasis,          |                                                                          |            |
          Multifocal                       |                4  3     2                                                |      5  3.2|
      Pars Distalis, Cyst                  | 4                                                                        |      3  3.0|
      Pars Distalis, Cyst, Multiple        |                         3                                                |      4  2.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  23                                                               
NTP Experiment-Test: 05072-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:30:54  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 7| 6| 6| 7| 7| 7| 5| 7| 7| 7| 7| 6| 5| 5| 7| 5| 7| 6| 4| 7| 6| 7|            |
                             DAY ON TEST   | 2| 8| 4| 2| 9| 6| 2| 1| 2| 6| 2| 2| 2| 2| 9| 6| 8| 2| 3| 2| 9| 7| 2| 6| 2|            |
                                           | 2| 9| 6| 8| 5| 7| 8| 9| 0| 7| 8| 8| 8| 8| 6| 0| 4| 8| 4| 8| 5| 5| 8| 5| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    5 PPM                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Pars Distalis, Hyperplasia, Focal    |                3                                2                    2  2|      8  2.1|
      Pars Intermedia, Angiectasis,        |                                                                          |            |
          Multifocal                       |                                                             2            |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      C-Cell, Hyperplasia, Focal           | 2                                                  4                     |      2  3.0|
      C-Cell, Hyperplasia, Multifocal      |          2        2           3                                   2      |     12  2.1|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                           +                              |   3        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +     M  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|  44        |
      Abscess                              |                                                                          |      1  4.0|
      Ectasia                              |                         4        2           3              2            |      6  2.8|
      Hyperplasia, Focal                   |                                                          2               |      1  2.0|
      Inflammation, Granulomatous,         |                                                                          |            |
          Multifocal                       |       1                                                                  |      1  1.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Cyst                                 |          3                                3                              |      5  3.0|
      Bilateral, Cyst                      |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                                                          |      3  3.0|
      Dilatation                           |                                                       2        1         |      4  2.5|
      Hyperplasia                          |                                  2                                       |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                                                          |      1  4.0|
      Hyperplasia                          | 2  3  2     2        2  4  2  3  3  2                 2     2           1|     25  2.5|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Plasma Cell             |                                                                          |      1  2.0|
      Mediastinal, Cyst                    |                                                                          |      2  2.5|
      Mediastinal, Hemorrhage              |                      2                 2  3                 3     2      |      9  2.7|
      Mediastinal, Hyperplasia, Lymphoid   |                                        2                                 |      1  2.0|
      Mediastinal, Hyperplasia             |                                              2                           |      1  2.0|
      Pancreatic, Hemorrhage               |                                                                          |      2  3.5|
      Pancreatic, Hyperplasia, Lymphoid    |                            2                                             |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  24                                                               
NTP Experiment-Test: 05072-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:30:54  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 7| 6| 6| 7| 7| 7| 5| 7| 7| 7| 7| 6| 5| 5| 7| 5| 7| 6| 4| 7| 6| 7|            |
                             DAY ON TEST   | 2| 8| 4| 2| 9| 6| 2| 1| 2| 6| 2| 2| 2| 2| 9| 6| 8| 2| 3| 2| 9| 7| 2| 6| 2|            |
                                           | 2| 9| 6| 8| 5| 7| 8| 9| 0| 7| 8| 8| 8| 8| 6| 0| 4| 8| 4| 8| 5| 5| 8| 5| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    5 PPM                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Hemorrhage, Acute                    |                                              2                           |      2  2.0|
      Hyperplasia, Lymphoid                |                                        2                                 |      2  2.5|
      Hyperplasia, Plasma Cell             |                                                                          |      1  3.0|
      Hyperplasia, Re Cell                 |                               2                                          |      1  2.0|
      Inflammation, Chronic Active         |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hemorrhage, Acute                    | 3     3                                                                  |      6  3.0|
      Hyperplasia, Lymphoid                |                                        2                                 |      1  2.0|
      Hyperplasia, Re Cell                 |                         2     2                       2                  |      5  2.2|
      Inflammation, Acute                  |                                                                      4   |      1  4.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Depletion Lymphoid                   |                                           3                              |      1  3.0|
      Fibrosis, Focal                      |                               3                                          |      1  3.0|
      Fibrosis, Multifocal                 |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     | 3  3  2     3        2                                      4            |     14  2.9|
      Hyperplasia, Re Cell                 |                                                                          |      1  4.0|
      Pigmentation, Hemosiderin            |                            2           2     3  2                    3   |      8  2.3|
      Capsule, Fibrosis, Multifocal        |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  M  +  +  +  +  M  M  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +|  42        |
      Congestion                           |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ectasia, Diffuse                     |                                              2     2                     |      4  2.5|
      Ectasia, Multifocal                  | 4           2  1  4  3     3     2  3           2        2           1   |     19  2.6|
      Fibrosis, Focal                      |                                                                          |      1  4.0|
      Galactocele                          | 4                                                                        |      3  4.0|
      Hyperplasia, Diffuse                 |                               2           3  2                           |      5  2.0|
      Hyperplasia, Focal                   |                            4                                             |      3  3.7|
      Hyperplasia, Multifocal              |                2  4                                               3      |      3  3.0|
      Inflammation, Granulomatous,         |                                                                          |            |
          Multifocal                       |    2                                                                     |      1  2.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst Epithelial Inclusion            |                                                                          |      1  4.0|
      Inflammation, Chronic Active, Focal  |                                                 2                        |      1  2.0|
      Inflammation, Multifocal, Subacute   | 3                                                                        |      1  3.0|
      Ulcer                                | 2                                                                        |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  25                                                               
NTP Experiment-Test: 05072-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:30:54  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 7| 6| 6| 7| 7| 7| 5| 7| 7| 7| 7| 6| 5| 5| 7| 5| 7| 6| 4| 7| 6| 7|            |
                             DAY ON TEST   | 2| 8| 4| 2| 9| 6| 2| 1| 2| 6| 2| 2| 2| 2| 9| 6| 8| 2| 3| 2| 9| 7| 2| 6| 2|            |
                                           | 2| 9| 6| 8| 5| 7| 8| 9| 0| 7| 8| 8| 8| 8| 6| 0| 4| 8| 4| 8| 5| 5| 8| 5| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    5 PPM                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Osteopetrosis                        |                                                                      3   |      4  3.3|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression                          |                            X                 X                           |      5     |
      Hydrocephalus                        |                            3                                             |      3  2.3|
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                 +                        |   1        |
      Degeneration, Multifocal, Secondary  |                                                                          |            |
          Wallerian                        |                                                 2                        |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia, Focal, Papillary        |                                                                          |      1  1.0|
      Inflammation, Acute                  |                      2                                         2         |      2  2.0|
      Inflammation, Chronic                |                               2        2                    2            |      6  1.5|
      Inflammation, Chronic Active         |                   2     2                 2                              |      8  1.9|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage, Acute, Multifocal        |                                                                         2|      1  2.0|
      Inflammation, Acute, Multifocal,     |                                                                          |            |
           Necrotizing                     |                                     4                                    |      1  4.0|
      Inflammation, Multifocal,            |                                                                          |            |
          Necrotizing, Subacute            |                         4                                                |      1  4.0|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Multifocal                      | 4  4  3  4  4  3  4  4  3  4  4  4  4  4  4  4  4  4  4  3  4  3  4  3  4|     50  3.7|
      Bronchiole, Hyperplasia, Multifocal  | 4  4  3  4  4  3  4  4  3  4  4  4  4  4  4  4  4  4  4  3  4     3  3  4|     48  3.7|
      Bronchiole, Alveolus, Inflammation,  |                                                                          |            |
           Acute, Multifocal, Suppurative  |                                                                          |      2  3.5|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Thrombosis, Multifocal               |                         2                                                |      1  2.0|
      Mucosa, Erosion, Multifocal          | 1                                                                        |      1  1.0|
      Mucosa, Inflammation, Acute          |                                                                          |      1  2.0|
      Mucosa, Inflammation, Chronic        |                                                                         1|      1  1.0|
      Mucosa, Inflammation, Chronic Active |                      3        2  1  1  2  1     2                 2      |     20  2.3|
      Mucosa, Inflammation, Chronic Active,|                                                                          |            |
           Suppurative                     |    2        4  2        4                    4              2            |     10  3.3|
      Mucosa, Ulcer                        |                                                                          |      1  2.0|
      Mucosa, Ulcer, Multifocal            |                      3                                                   |      1  3.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  26                                                               
NTP Experiment-Test: 05072-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:30:54  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 7| 6| 6| 7| 7| 7| 5| 7| 7| 7| 7| 6| 5| 5| 7| 5| 7| 6| 4| 7| 6| 7|            |
                             DAY ON TEST   | 2| 8| 4| 2| 9| 6| 2| 1| 2| 6| 2| 2| 2| 2| 9| 6| 8| 2| 3| 2| 9| 7| 2| 6| 2|            |
                                           | 2| 9| 6| 8| 5| 7| 8| 9| 0| 7| 8| 8| 8| 8| 6| 0| 4| 8| 4| 8| 5| 5| 8| 5| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    5 PPM                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
           Chronic                         |                                                                          |      1  3.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Chronic Active                  |                                              2                           |      2  2.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Chronic Active, Suppurative     |                                  2                                       |      1  2.0|
      Olfactory Epithelium, Atrophy        |          1                                                               |      1  1.0|
      Respiratory Epithelium, Hyperplasia  |             1        1  2  2           1     2              1     2      |     21  1.6|
      Respiratory Epithelium, Hyperplasia, |                                                                          |            |
           Papillary                       |                                                                          |      1  2.0|
      Respiratory Epithelium, Metaplasia,  |                                                                          |            |
           Squamous                        |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                |                                                                          |      2  2.0|
      Inflammation, Chronic Active         |                                                                          |      2  2.0|
      Inflammation, Necrotizing, Subacute  |                         2                                                |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infarct                              |                                                                          |      2  2.0|
      Nephropathy, Chronic                 | 4  2  2  3  2  1  3  3  2  4  3  4  4  3  1  2  1  3  1  4  2     4  3  3|     44  2.4|
      Pigmentation, Multifocal             |                                                                          |      1  2.0|
      Bilateral, Hydronephrosis            |       2                                                                  |      1  2.0|
      Pelvis, Epithelium, Mineralization   |                                                                1         |      3  1.7|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|  48        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  27                                                               
NTP Experiment-Test: 05072-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:30:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 5| 6|             
                             DAY ON TEST   | 8| 1| 2| 2| 5| 2| 2| 1| 2| 0| 2| 2| 8| 2| 2| 6| 2| 2| 8| 2| 2| 2| 2| 4| 3|             
                                           | 4| 6| 7| 7| 9| 7| 7| 9| 7| 6| 8| 8| 7| 8| 8| 3| 8| 8| 1| 9| 9| 9| 9| 5| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    2 PPM                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
      Parasite Metazoan                    |                X                                                         |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |          X     X              X        X                 X               |             
      Muscularis, Mineralization,          |                                                                          |             
          Multifocal                       |                                              3                           |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |          X     X                       X     X  X                        |             
      Muscularis, Mineralization,          |                                                                          |             
          Multifocal                       |                                              2                           |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis, Focal                   |             2                                                            |             
      Basophilic Focus                     |                                                          X               |             
      Basophilic Focus, Multiple           |       X        X  X     X  X  X  X     X  X     X           X  X  X      |             
      Basophilic Focus, Two                |             X                       X        X     X                     |             
      Cytomegaly, Multifocal               |                                                                          |             
      Cytoplasmic Alteration, Focal        |                         2                                                |             
      Eosinophilic Focus                   |                                                                          |             
      Fatty Change, Diffuse                | 1                                                     3                  |             
      Fatty Change, Multifocal             |                      4                       1                       3   |             
      Fibrosis, Multifocal                 |                            1                                             |             
      Granuloma, Multifocal                |       1     1  1  2     2  2  1  1  2  2  1     2     1           2     2|             
      Hepatodiaphragmatic Nodule           | X              X           X              X                              |             
      Hyperplasia, Nodular                 |          2                                                               |             
      Mitotic Alteration                   |          2           2                                                   |             
      Mixed Cell Focus                     |                                                                          |             
      Necrosis, Acute, Multifocal          |    1     1                                                               |             
      Vacuolization Cytoplasmic, Multifocal|                                                                1         |             
      Bile Duct, Hyperplasia, Multifocal   |          2     1           2                                             |             
      Centrilobular, Atrophy, Multifocal   |          3                                   1                           |             
      Centrilobular, Congestion, Multifocal|          4                                                               |             
      Centrilobular, Necrosis, Acute,      |                                                                          |             
          Multifocal                       | 2                                                                        |             
      Periportal, Cytomegaly, Diffuse      |                         2                                                |             
      Periportal, Fatty Change, Diffuse    |                                                                          |             
      Periportal, Fatty Change, Multifocal |                         2                                                |             
      Portal, Inflammation, Chronic,       |                                                                          |             
          Multifocal                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  28                                                               
NTP Experiment-Test: 05072-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:30:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 5| 6|             
                             DAY ON TEST   | 8| 1| 2| 2| 5| 2| 2| 1| 2| 0| 2| 2| 8| 2| 2| 6| 2| 2| 8| 2| 2| 2| 2| 4| 3|             
                                           | 4| 6| 7| 7| 9| 7| 7| 9| 7| 6| 8| 8| 7| 8| 8| 3| 8| 8| 1| 9| 9| 9| 9| 5| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    2 PPM                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |             +        +  +           +        +              +            |             
      Artery, Mineralization, Multifocal   |                                              4                           |             
      Fat, Necrosis, Focal                 |             3        4                                      3            |             
      Fat, Necrosis, Multifocal            |                         3                                                |             
      Vein, Thrombosis                     |                                     3                                    |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic, Multifocal    |                                                                          |             
      Acinus, Atrophy, Multifocal          |          2        2     3        2                                       |             
      Acinus, Hyperplasia, Focal           |                            2                                             |             
      Artery, Angiectasis, Multifocal      |                                              3                           |             
      Artery, Mineralization, Multifocal   |                                              3                           |             
      Serosa, Inflammation, Chronic Active | 4                                                                        |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy, Focal               |                                                                          |             
      Duct, Hyperplasia, Focal             |                                        2                                 |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic Active         | 2                          3                                         3   |             
      Ulcer, Single                        | 1                          1                                             |             
      Epithelium, Hyperplasia, Diffuse     | 2                                                                        |             
      Epithelium, Hyperplasia, Focal       |                                                                      2   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                            2                                         3   |             
      Necrosis, Focal, Subacute            |                                                                      4   |             
      Mucosa, Mineralization               |                                              3                           |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1  1  2  2     2  2     1  2  3  2     2  1  2  1  2  2        2  2      |             
      Mineralization, Multifocal           |                                              2                           |             
      Necrosis, Acute, Multifocal          |                                              3                           |             
      Artery, Amyloid Deposition,          |                                                                          |             
          Multifocal                       |                            3                                             |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Capsule, Accessory Adrenal Cortical  |                                                                          |             
          Nodule                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis, Focal                   |                                                                          |             
      Angiectasis, Multifocal              |                                                                          |             
      Congestion                           |                                                                      3   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  29                                                               
NTP Experiment-Test: 05072-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:30:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 5| 6|             
                             DAY ON TEST   | 8| 1| 2| 2| 5| 2| 2| 1| 2| 0| 2| 2| 8| 2| 2| 6| 2| 2| 8| 2| 2| 2| 2| 4| 3|             
                                           | 4| 6| 7| 7| 9| 7| 7| 9| 7| 6| 8| 8| 7| 8| 8| 3| 8| 8| 1| 9| 9| 9| 9| 5| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    2 PPM                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Degeneration, Fatty, Focal           |       3  3                 1                                         2   |             
      Degeneration, Fatty, Multifocal      |                2                                                         |             
      Hyperplasia, Focal                   | 1              1                 1     3                                1|             
      Hyperplasia, Multifocal              |                         2     1                                          |             
      Hypertrophy, Focal                   |          2     2                                   2                     |             
      Hypertrophy, Multifocal              |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                                                          |             
      Hyperplasia, Multifocal              |                                              2                           |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |          3                                                  2            |             
      Hyperplasia, Multifocal              |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Diffuse                 |                                              3                           |             
      Hypertrophy, Focal                   |                                                          2               |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Abscess, Chronic      |                                                                          |             
      Pars Distalis, Angiectasis, Focal    |                                                                          |             
      Pars Distalis, Angiectasis,          |                                                                          |             
          Multifocal                       | 2        2                                                               |             
      Pars Distalis, Cyst                  |                3  3                                                      |             
      Pars Distalis, Cyst, Multiple        |    2                                                                     |             
      Pars Distalis, Hyperplasia, Focal    |    2                             2                          3     2      |             
      Pars Distalis, Hyperplasia           |                                                                3         |             
      Pars Intermedia, Angiectasis,        |                                                                          |             
          Multifocal                       |                                                                         3|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia, Focal           |                         3              2                                 |             
      C-Cell, Hyperplasia, Multifocal      |                   2           1                 2        2     2  2      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                                          |             
      Ectasia                              |                                                             3            |             
      Hyperplasia, Diffuse                 |                                                                          |             
      Hyperplasia, Focal                   |                               2                             3     3      |             
      Inflammation, Focal, Granulomatous   |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |          X                                      3                        |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst, Multiple                       |                                                                3         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  30                                                               
NTP Experiment-Test: 05072-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:30:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 5| 6|             
                             DAY ON TEST   | 8| 1| 2| 2| 5| 2| 2| 1| 2| 0| 2| 2| 8| 2| 2| 6| 2| 2| 8| 2| 2| 2| 2| 4| 3|             
                                           | 4| 6| 7| 7| 9| 7| 7| 9| 7| 6| 8| 8| 7| 8| 8| 3| 8| 8| 1| 9| 9| 9| 9| 5| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    2 PPM                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Dilatation                           |                                                                          |             
      Hyperplasia                          |          2        2                                                      |             
      Inflammation, Acute, Suppurative     |                         2                                                |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 4  2  3  3              3     2        4     2     2        3           2|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Axillary, Hemorrhage, Acute          |                                              3                           |             
      Mediastinal, Edema                   |                                                                         3|             
      Mediastinal, Hemorrhage              | 3           3                                                            |             
      Pancreatic, Hemorrhage               |    3                             2                                   3   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                       3                  |             
      Hyperplasia, Plasma Cell             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Hemorrhage, Acute                    |                2                                                     2   |             
      Hyperplasia, Lymphoid                | 2                                                                        |             
      Hyperplasia, Re Cell                 |                                                       2                  |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Depletion Lymphoid                   |                                                                          |             
      Fibrosis, Multifocal                 |                                                                          |             
      Hematopoietic Cell Proliferation     | 4                                            3                           |             
      Pigmentation, Hemosiderin            |                2           2     2  2     2                              |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M|             
      Epithelial Cell, Hyperplasia         |                                                    2                     |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia, Multifocal                  |                   2     3  2        4     3        3  3  2               |             
      Hyperplasia, Diffuse                 |          2                       2                                       |             
      Hyperplasia, Focal                   |                                           4                              |             
      Hyperplasia, Multifocal              |             2                                      3           3         |             
      Mineralization, Multifocal           |                                              2                           |             
      Duct, Ectasia, Focal                 |                                           4  3                           |             
      Duct, Ectasia, Multifocal            |       4                                                                  |             
      Duct, Hyperplasia, Multifocal        |                                        2                                 |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  31                                                               
NTP Experiment-Test: 05072-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:30:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 5| 6|             
                             DAY ON TEST   | 8| 1| 2| 2| 5| 2| 2| 1| 2| 0| 2| 2| 8| 2| 2| 6| 2| 2| 8| 2| 2| 2| 2| 4| 3|             
                                           | 4| 6| 7| 7| 9| 7| 7| 9| 7| 6| 8| 8| 7| 8| 8| 3| 8| 8| 1| 9| 9| 9| 9| 5| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    2 PPM                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
      Fibrous Osteodystrophy               |                                              4                           |             
      Osteopetrosis                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |             X           X  X        X                 X  X               |             
      Hydrocephalus                        |             4                                         3                  |             
      Choroid Plexus, Hyperplasia, Focal   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal, Papillary        |                                                                          |             
      Inflammation, Acute                  |          2  1                                                            |             
      Inflammation, Chronic                |                                                    2              2      |             
      Inflammation, Chronic Active         |                      2  2           2  1                                 |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage, Acute, Focal             |                                                                          |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Atypical, Focal                 |                                                                          |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |    1                                3     2                              |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Multifocal                      | 2     2  4  3  4  3     4  3  4  3     3        2  4     2  3  2  2     3|             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Multifocal, Histiocyte          |                                                                          |             
      Bronchiole, Hyperplasia, Focal       |    1                                      2                              |             
      Bronchiole, Hyperplasia, Multifocal  |       2  4  3  4  3     4  3  4  3     3        2        2  3  2  2     3|             
      Bronchus, Hyperplasia, Focal,        |                                                                          |             
          Papillary                        |                                                                          |             
      Interstitium, Inflammation, Chronic, |                                                                          |             
           Focal                           |                                                                          |             
      Interstitium, Mineralization,        |                                                                          |             
          Multifocal                       |                                              2                           |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mucosa, Foreign Body                 |                                                             2            |             
      Mucosa, Inflammation, Chronic        |                2              1                                          |             
      Mucosa, Inflammation, Chronic Active |                         1        2     2  2     1                        |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Chronic                         |             1              1     1                                       |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Chronic Active                  |                                     3     2           3                  |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Chronic Active, Suppurative     |                                                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  32                                                               
NTP Experiment-Test: 05072-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:30:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 5| 6|             
                             DAY ON TEST   | 8| 1| 2| 2| 5| 2| 2| 1| 2| 0| 2| 2| 8| 2| 2| 6| 2| 2| 8| 2| 2| 2| 2| 4| 3|             
                                           | 4| 6| 7| 7| 9| 7| 7| 9| 7| 6| 8| 8| 7| 8| 8| 3| 8| 8| 1| 9| 9| 9| 9| 5| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    2 PPM                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
           Suppurative                     |                                                          2               |             
      Respiratory Epithelium, Hyperplasia  |                                                             1            |             
      Respiratory Epithelium, Hyperplasia, |                                                                          |             
           Papillary                       |                                        2                                 |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                                     2                                    |             
      Inflammation, Chronic Active         |                                                       3                  |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                  +           +                           |             
      Cataract                             |                                  2                                       |             
      Anterior, Synechia                   |                                  4                                       |             
      Cornea, Neovascularization,          |                                                                          |             
          Multifocal                       |                                              1                           |             
      Retina, Degeneration                 |                                  4                                       |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
      Ectasia                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy, Chronic                 | 1     1  3  4  3  3  2  4  2  4  4  3  2  3  4  2  4  4  4  1  3  4     1|             
      Pigmentation, Diffuse                |                      2                                               2   |             
      Artery, Mineralization, Multifocal   |                                              2                           |             
      Capsule, Inflammation, Chronic       | 2                                                                        |             
      Pelvis, Epithelium, Mineralization   | 1                                                                        |             
      Proximal Convoluted Renal Tubule,    |                                                                          |             
           Hyperplasia, Atypical, Focal    |                                                                          |             
      Proximal Convoluted Renal Tubule,    |                                                                          |             
           Necrosis, Acute                 |       3                                                     2            |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  33                                                               
NTP Experiment-Test: 05072-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:30:54  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 5| 6| 7| 7| 7| 7| 4| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 2| 2| 2| 7| 0| 2| 2| 2| 0| 2| 2| 2| 8| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|            |
                                           | 9| 9| 9| 7| 3| 9| 9| 9| 3| 8| 9| 9| 9| 9| 2| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    2 PPM                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Parasite Metazoan                    |                                                             X            |      2     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  49        |
      Parasite Metazoan                    |             X  X                 X              X                 X      |     10     |
      Muscularis, Mineralization,          |                                                                          |            |
          Multifocal                       |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Parasite Metazoan                    |    X                                         X                           |      7     |
      Muscularis, Mineralization,          |                                                                          |            |
          Multifocal                       |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis, Focal                   |                                              3                           |      2  2.5|
      Basophilic Focus                     |                X                                                         |      2     |
      Basophilic Focus, Multiple           | X  X        X     X     X     X  X     X  X  X  X     X     X  X  X  X   |     29     |
      Basophilic Focus, Two                |       X                                                  X               |      6     |
      Cytomegaly, Multifocal               |                                                             2            |      1  2.0|
      Cytoplasmic Alteration, Focal        |                                              3                           |      2  2.5|
      Eosinophilic Focus                   | X                       X                                                |      2     |
      Fatty Change, Diffuse                |                                                                          |      2  2.0|
      Fatty Change, Multifocal             |                                     3                       1           2|      6  2.3|
      Fibrosis, Multifocal                 |                                                                          |      1  1.0|
      Granuloma, Multifocal                | 1     1  3  2  2           1  1     2              3     1  3        2  1|     28  1.6|
      Hepatodiaphragmatic Nodule           |                                                                          |      4     |
      Hyperplasia, Nodular                 |                                                                          |      1  2.0|
      Mitotic Alteration                   |                                                             2            |      3  2.0|
      Mixed Cell Focus                     |                                  X           X                           |      2     |
      Necrosis, Acute, Multifocal          |                                                                          |      2  1.0|
      Vacuolization Cytoplasmic, Multifocal|                      1                                                   |      2  1.0|
      Bile Duct, Hyperplasia, Multifocal   |                            1                    1                 1      |      6  1.3|
      Centrilobular, Atrophy, Multifocal   |                                                                          |      2  2.0|
      Centrilobular, Congestion, Multifocal|                                                                          |      1  4.0|
      Centrilobular, Necrosis, Acute,      |                                                                          |            |
          Multifocal                       |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  34                                                               
NTP Experiment-Test: 05072-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:30:54  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 5| 6| 7| 7| 7| 7| 4| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 2| 2| 2| 7| 0| 2| 2| 2| 0| 2| 2| 2| 8| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|            |
                                           | 9| 9| 9| 7| 3| 9| 9| 9| 3| 8| 9| 9| 9| 9| 2| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    2 PPM                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Periportal, Cytomegaly, Diffuse      |                                                                          |      1  2.0|
      Periportal, Fatty Change, Diffuse    |                                           2                              |      1  2.0|
      Periportal, Fatty Change, Multifocal |             2                                                            |      2  2.0|
      Portal, Inflammation, Chronic,       |                                                                          |            |
          Multifocal                       |                            1                                             |      1  1.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   6        |
      Artery, Mineralization, Multifocal   |                                                                          |      1  4.0|
      Fat, Necrosis, Focal                 |                                                                          |      3  3.3|
      Fat, Necrosis, Multifocal            |                                                                          |      1  3.0|
      Vein, Thrombosis                     |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic, Multifocal    |          1                                                               |      1  1.0|
      Acinus, Atrophy, Multifocal          |                         1              1                 4           1   |      8  2.0|
      Acinus, Hyperplasia, Focal           |                                  2                                       |      2  2.0|
      Artery, Angiectasis, Multifocal      |                                                                          |      1  3.0|
      Artery, Mineralization, Multifocal   |                                                                          |      1  3.0|
      Serosa, Inflammation, Chronic Active |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acinus, Atrophy, Focal               |                                                 1                        |      1  1.0|
      Duct, Hyperplasia, Focal             |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Acute                  |                                     3                                    |      1  3.0|
      Inflammation, Chronic Active         |                                                                          |      3  2.7|
      Ulcer, Single                        |                                                                          |      2  1.0|
      Epithelium, Hyperplasia, Diffuse     |                                                                          |      1  2.0|
      Epithelium, Hyperplasia, Focal       |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Chronic Active         |                                                                          |      2  2.5|
      Necrosis, Focal, Subacute            |                                                                          |      1  4.0|
      Mucosa, Mineralization               |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                              +                           |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       | 2  4     2  2     3  2  2     1  2  1  1  1  1  1  2  3  3  2  2  2  2   |     39  1.9|
      Mineralization, Multifocal           |                                                                          |      1  2.0|
      Necrosis, Acute, Multifocal          |                                                                          |      1  3.0|
      Artery, Amyloid Deposition,          |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  35                                                               
NTP Experiment-Test: 05072-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:30:54  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 5| 6| 7| 7| 7| 7| 4| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 2| 2| 2| 7| 0| 2| 2| 2| 0| 2| 2| 2| 8| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|            |
                                           | 9| 9| 9| 7| 3| 9| 9| 9| 3| 8| 9| 9| 9| 9| 2| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    2 PPM                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
          Multifocal                       |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Capsule, Accessory Adrenal Cortical  |                                                                          |            |
          Nodule                           |                                                       X                  |      1     |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|  49        |
      Angiectasis, Focal                   |                                                    2                     |      1  2.0|
      Angiectasis, Multifocal              |                                                 2                        |      1  2.0|
      Congestion                           |                                                                          |      1  3.0|
      Degeneration, Fatty, Focal           |                                     3        2                    2      |      7  2.3|
      Degeneration, Fatty, Multifocal      |                                                                          |      1  2.0|
      Hyperplasia, Focal                   | 1                                                     2     2           1|      9  1.4|
      Hyperplasia, Multifocal              |                         2              2                          2      |      5  1.8|
      Hypertrophy, Focal                   |       1                                                           2      |      5  1.8|
      Hypertrophy, Multifocal              |    1                                                                     |      1  1.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|  48        |
      Hyperplasia, Focal                   |                   2                                                      |      1  2.0|
      Hyperplasia, Multifocal              |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Focal                   |                                                                          |      2  2.5|
      Hyperplasia, Multifocal              |                                     1     2        1     3  2        2   |      6  1.8|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Hyperplasia, Diffuse                 |                                                                          |      1  3.0|
      Hypertrophy, Focal                   |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  I  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  48        |
      Pars Distalis, Abscess, Chronic      |                                                    2                     |      1  2.0|
      Pars Distalis, Angiectasis, Focal    |                                                          3               |      1  3.0|
      Pars Distalis, Angiectasis,          |                                                                          |            |
          Multifocal                       |                                                                          |      2  2.0|
      Pars Distalis, Cyst                  |                                                                          |      2  3.0|
      Pars Distalis, Cyst, Multiple        | 2                                                                 1      |      3  1.7|
      Pars Distalis, Hyperplasia, Focal    |                                                                          |      4  2.3|
      Pars Distalis, Hyperplasia           |                                                                          |      1  3.0|
      Pars Intermedia, Angiectasis,        |                                                                          |            |
          Multifocal                       |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      C-Cell, Hyperplasia, Focal           |                         3                                                |      3  2.7|
      C-Cell, Hyperplasia, Multifocal      |                1                                         1  1        2   |     10  1.6|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  36                                                               
NTP Experiment-Test: 05072-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:30:54  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 5| 6| 7| 7| 7| 7| 4| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 2| 2| 2| 7| 0| 2| 2| 2| 0| 2| 2| 2| 8| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|            |
                                           | 9| 9| 9| 7| 3| 9| 9| 9| 3| 8| 9| 9| 9| 9| 2| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    2 PPM                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Abscess                              |                               4     3                                    |      2  3.5|
      Ectasia                              |                                                          4              3|      3  3.3|
      Hyperplasia, Diffuse                 |                                                          4               |      1  4.0|
      Hyperplasia, Focal                   |                                                                          |      3  2.7|
      Inflammation, Focal, Granulomatous   |                                              2                           |      1  2.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |          4                    3                                      3   |      5  3.3|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst, Multiple                       |                                                    3                 2   |      3  2.7|
      Dilatation                           |             1                                                            |      1  1.0|
      Hyperplasia                          |                                                                          |      2  2.0|
      Inflammation, Acute, Suppurative     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Vagina                                  |                                           +                              |   1        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                         4  3  2     2     2        2  2              2  1|     20  2.5|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Axillary, Hemorrhage, Acute          |                                                                          |      1  3.0|
      Mediastinal, Edema                   |                                                                          |      1  3.0|
      Mediastinal, Hemorrhage              | 3     3  3  4                                                  3         |      7  3.1|
      Pancreatic, Hemorrhage               |                                                                          |      3  2.7|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
      Hyperplasia, Plasma Cell             |                                                             2            |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Atrophy                              |                                                 2                        |      1  2.0|
      Hemorrhage, Acute                    |                               2                                3         |      4  2.3|
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
      Hyperplasia, Re Cell                 |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                                                    3                     |      1  3.0|
      Depletion Lymphoid                   |                                     4                                    |      1  4.0|
      Fibrosis, Multifocal                 |                                     3                                    |      1  3.0|
      Hematopoietic Cell Proliferation     |                                                                          |      2  3.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  37                                                               
NTP Experiment-Test: 05072-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:30:54  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 5| 6| 7| 7| 7| 7| 4| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 2| 2| 2| 7| 0| 2| 2| 2| 0| 2| 2| 2| 8| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|            |
                                           | 9| 9| 9| 7| 3| 9| 9| 9| 3| 8| 9| 9| 9| 9| 2| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    2 PPM                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Pigmentation, Hemosiderin            |          2                          3  3        1                        |      9  2.1|
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Epithelial Cell, Hyperplasia         |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ectasia, Multifocal                  |          3  3     2  2  1     2     2              4        1           3|     18  2.5|
      Hyperplasia, Diffuse                 |                                        1           2                     |      4  1.8|
      Hyperplasia, Focal                   |                               4                                          |      2  4.0|
      Hyperplasia, Multifocal              |                                                                          |      3  2.7|
      Mineralization, Multifocal           |                                                                          |      1  2.0|
      Duct, Ectasia, Focal                 |                                                                          |      2  3.5|
      Duct, Ectasia, Multifocal            |                                                                          |      1  4.0|
      Duct, Hyperplasia, Multifocal        |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrous Osteodystrophy               |                                                                          |      1  4.0|
      Osteopetrosis                        |                3                             2           2  4            |      4  2.8|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression                          |          X  X                       X              X        X           X|     12     |
      Hydrocephalus                        |          2  3                       2                                    |      5  2.8|
      Choroid Plexus, Hyperplasia, Focal   |                                        3                                 |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia, Focal, Papillary        |                                        2                                 |      1  2.0|
      Inflammation, Acute                  |                                                                          |      2  1.5|
      Inflammation, Chronic                |             2           1                                                |      4  1.8|
      Inflammation, Chronic Active         | 1                             2        2        3  2     2               |     10  1.9|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage, Acute, Focal             |                                                    3                     |      1  3.0|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Atypical, Focal                 |                                           4                              |      1  4.0|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |             2                 1                                          |      5  1.8|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  38                                                               
NTP Experiment-Test: 05072-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:30:54  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 5| 6| 7| 7| 7| 7| 4| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 2| 2| 2| 7| 0| 2| 2| 2| 0| 2| 2| 2| 8| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|            |
                                           | 9| 9| 9| 7| 3| 9| 9| 9| 3| 8| 9| 9| 9| 9| 2| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    2 PPM                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Multifocal                      | 2  4  2        2  3  4  2        2  1  4  2  3  4  4  3  2  2  3  1  2   |     38  2.8|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Multifocal, Histiocyte          |                                                             1            |      1  1.0|
      Bronchiole, Hyperplasia, Focal       |                                                                          |      2  1.5|
      Bronchiole, Hyperplasia, Multifocal  |    4  2        2        2              4     3  4  4        2  2         |     26  2.9|
      Bronchus, Hyperplasia, Focal,        |                                                                          |            |
          Papillary                        |    4                                                                     |      1  4.0|
      Interstitium, Inflammation, Chronic, |                                                                          |            |
           Focal                           |                                                                   2      |      1  2.0|
      Interstitium, Mineralization,        |                                                                          |            |
          Multifocal                       |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mucosa, Foreign Body                 |                                                                          |      1  2.0|
      Mucosa, Inflammation, Chronic        |                                                                          |      2  1.5|
      Mucosa, Inflammation, Chronic Active |    1                                            1                        |      7  1.4|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Chronic                         |                                                                          |      3  1.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Chronic Active                  |                                                                          |      3  2.7|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Chronic Active, Suppurative     |                                                    2     2               |      2  2.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |                                                                          |      1  2.0|
      Respiratory Epithelium, Hyperplasia  |                                                             1            |      2  1.0|
      Respiratory Epithelium, Hyperplasia, |                                                                          |            |
           Papillary                       |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Acute                  |                                                                          |      1  2.0|
      Inflammation, Chronic Active         |             2                                                            |      2  2.5|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |             +                                                            |   3        |
      Cataract                             |                                                                          |      1  2.0|
      Anterior, Synechia                   |                                                                          |      1  4.0|
      Cornea, Neovascularization,          |                                                                          |            |
          Multifocal                       |                                                                          |      1  1.0|
      Retina, Degeneration                 |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |          +                                                               |   1        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  39                                                               
NTP Experiment-Test: 05072-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:30:54  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 5| 6| 7| 7| 7| 7| 4| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 2| 2| 2| 7| 0| 2| 2| 2| 0| 2| 2| 2| 8| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|            |
                                           | 9| 9| 9| 7| 3| 9| 9| 9| 3| 8| 9| 9| 9| 9| 2| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    2 PPM                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Ectasia                              |          3                                                               |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Nephropathy, Chronic                 | 3  4  2  3  4  4  3  3  2  1  3  4  4  4  1  3  4  4  2  4  4  3  2     4|     47  3.0|
      Pigmentation, Diffuse                |                                                                          |      2  2.0|
      Artery, Mineralization, Multifocal   |                                                                          |      1  2.0|
      Capsule, Inflammation, Chronic       |                                                                          |      1  2.0|
      Pelvis, Epithelium, Mineralization   |                         3  1                                             |      3  1.7|
      Proximal Convoluted Renal Tubule,    |                                                                          |            |
           Hyperplasia, Atypical, Focal    |    2                                                                     |      1  2.0|
      Proximal Convoluted Renal Tubule,    |                                                                          |            |
           Necrosis, Acute                 |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  40                                                               
NTP Experiment-Test: 05072-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:30:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 4| 6| 2| 6| 7| 6| 7| 7| 6| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 6| 6| 7| 6|             
                             DAY ON TEST   | 2| 6| 2| 5| 9| 4| 2| 4| 0| 2| 4| 2| 8| 0| 2| 2| 4| 2| 2| 2| 2| 1| 4| 2| 1|             
                                           | 7| 3| 2| 8| 4| 4| 4| 6| 7| 7| 9| 7| 6| 8| 3| 7| 5| 7| 7| 8| 8| 8| 4| 3| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Serosa, Hemorrhage, Chronic, Focal   |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  M  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Parasite Metazoan                    |          X                                                               |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Parasite Metazoan                    |                               X  X                                       |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  M  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                    X                     |             
      Serosa, Inflammation, Chronic        |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  A  +  A  +  +  +  +  +  A  +  +     +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Eosinophil,   |                                                                          |             
           Histiocyte                      |                                  4                                       |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  A  +  A  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +|             
      Peyer's Patch, Hyperplasia, Lymphoid |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis, Focal                   |                   2                                                      |             
      Angiectasis, Multifocal              | 3                                                                        |             
      Basophilic Focus                     |                                                                          |             
      Basophilic Focus, Multiple           |          X                                                        X     X|             
      Basophilic Focus, Two                |                                                                          |             
      Clear Cell Focus                     |                                        2                                 |             
      Congestion, Diffuse                  |             3                                                            |             
      Cytomegaly, Diffuse                  |                                                                          |             
      Cytomegaly, Multifocal               |                               2           1                              |             
      Degeneration, Ballooning, Focal      |                                                    2        3            |             
      Degeneration, Ballooning, Multifocal |                                                                          |             
      Eosinophilic Focus                   |                                                                          |             
      Fatty Change, Diffuse                |                      4                                               4   |             
      Fatty Change, Multifocal             |       2                                1                                 |             
      Fibrosis, Focal                      |                                                                          |             
      Granuloma, Multifocal                |          1                             1                                 |             
      Mitotic Alteration                   |    3                          3                                          |             
      Necrosis, Acute, Multifocal          |                      1                                                   |             
      Vacuolization Cytoplasmic, Multifocal|          1                                                        1      |             
      Bile Duct, Hyperplasia, Multifocal   | 1  4              1  4     2  3  4        2  2  2  4  2  1  2  2         |             
      Centrilobular, Atrophy, Diffuse      |    3                                                                     |             
      Centrilobular, Atrophy, Multifocal   |                                  2                          2            |             
      Centrilobular, Fatty Change, Diffuse |                                                                4         |             
      Centrilobular, Fatty Change,         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  41                                                               
NTP Experiment-Test: 05072-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:30:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 4| 6| 2| 6| 7| 6| 7| 7| 6| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 6| 6| 7| 6|             
                             DAY ON TEST   | 2| 6| 2| 5| 9| 4| 2| 4| 0| 2| 4| 2| 8| 0| 2| 2| 4| 2| 2| 2| 2| 1| 4| 2| 1|             
                                           | 7| 3| 2| 8| 4| 4| 4| 6| 7| 7| 9| 7| 6| 8| 3| 7| 5| 7| 7| 8| 8| 8| 4| 3| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
          Multifocal                       |                                                                          |             
      Centrilobular, Necrosis, Diffuse     |                3                                                         |             
      Centrilobular, Necrosis, Multifocal  |                                              4                           |             
      Median Lobe, Hepatodiaphragmatic     |                                                                          |             
          Nodule                           |                                                                          |             
      Periportal, Cytomegaly, Diffuse      |    3                                                                     |             
      Periportal, Fatty Change, Multifocal |                                                                          |             
      Portal, Fibrosis, Multifocal         | 1                                                                        |             
      Portal, Inflammation, Chronic,       |                                                                          |             
          Multifocal                       |                            1                                             |             
      Portal, Inflammation, Granulomatous, |                                                                          |             
           Multifocal                      |                                                                          |             
      Serosa, Inflammation, Chronic Active,|                                                                          |             
           Focal, Proliferative            |                                                                          |             
      Vein, Thrombosis                     |                               2                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                         +|             
      Pigmentation                         |                                                                         4|             
      Fat, Necrosis, Focal                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pigmentation                         |                                                                         4|             
      Acinus, Atrophy, Focal               |                                                                          |             
      Acinus, Atrophy, Multifocal          |    3           3  2           2           1     1           2  3  2      |             
      Artery, Adventitia, Inflammation,    |                                                                          |             
           Chronic Active, Multifocal      |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic, Focal         |                                                                         2|             
      Parotid Gland, Inflammation, Chronic |                                                                          |             
          Active, Diffuse                  |                                                                      4   |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute, Focal           |                         3                                                |             
      Inflammation, Chronic                |                   2                                                      |             
      Inflammation, Chronic Active         |                                                          4     3         |             
      Ulcer                                |                                                          4     3     4   |             
      Epithelium, Hyperplasia, Diffuse     |                   2                                            2     3   |             
      Epithelium, Hyperplasia, Focal       |                                                                          |             
      Muscularis, Hyperplasia, Focal       |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Mucosa, Necrosis, Acute, Multifocal  |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |                         +                          +                     |             
      Epithelium, Hyperplasia, Focal       |                                                    4                     |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                     +                                    |             
      Abscess                              |                                     4                                    |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  42                                                               
NTP Experiment-Test: 05072-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:30:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 4| 6| 2| 6| 7| 6| 7| 7| 6| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 6| 6| 7| 6|             
                             DAY ON TEST   | 2| 6| 2| 5| 9| 4| 2| 4| 0| 2| 4| 2| 8| 0| 2| 2| 4| 2| 2| 2| 2| 1| 4| 2| 1|             
                                           | 7| 3| 2| 8| 4| 4| 4| 6| 7| 7| 9| 7| 6| 8| 3| 7| 5| 7| 7| 8| 8| 8| 4| 3| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Developmental Malformation           |                                     4                                    |             
      Gingiva, Inflammation                |                                     4                                    |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                             +            |             
      Inflammation, Chronic, Focal,        |                                                                          |             
          Necrotizing                      |                                                             2            |             
      Mineralization, Focal                |                                                                          |             
      Intima, Fibrosis, Multifocal         |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 3  1  2  1  2  3  2  2  3  2  1  3  2  3  2  2  1  3  3  3  4  2  2  3  2|             
      Atrium Left, Thrombosis              |                                              4                 3         |             
      Myocardium, Inflammation, Chronic,   |                                                                          |             
           Focal                           |                                                                          |             
      Ventricle Left, Dilatation           |                                              3                           |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Capsule, Accessory Adrenal Cortical  |                                                                          |             
          Nodule                           |          X        X  X                                                   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Diffuse, Fatty         |             2                                                  2     4   |             
      Degeneration, Fatty, Focal           |                      3           4                    1                  |             
      Degeneration, Fatty, Multifocal      |                         2              3                                 |             
      Degeneration, Multifocal             |                                                          2               |             
      Hyperplasia, Focal                   |                            1  2                    2        2            |             
      Hyperplasia, Multifocal              |          2                                                               |             
      Hypertrophy, Focal                   |                                                                         2|             
      Necrosis, Acute, Focal               |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  M  M  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                           1     1        1               |             
      Hyperplasia, Multifocal              |                2                 3     1                       2     3   |             
      Necrosis, Acute, Focal               |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                                       3                  |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  M  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Diffuse                 |                                        3                 2           3   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                   4                             2                        |             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Cyst, Multiple        |                                                                          |             
      Pars Distalis, Developmental         |                                                                          |             
          Malformation                     |                                                                          |             
      Pars Distalis, Hyperplasia, Focal    |                                                 3                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  43                                                               
NTP Experiment-Test: 05072-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:30:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 4| 6| 2| 6| 7| 6| 7| 7| 6| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 6| 6| 7| 6|             
                             DAY ON TEST   | 2| 6| 2| 5| 9| 4| 2| 4| 0| 2| 4| 2| 8| 0| 2| 2| 4| 2| 2| 2| 2| 1| 4| 2| 1|             
                                           | 7| 3| 2| 8| 4| 4| 4| 6| 7| 7| 9| 7| 6| 8| 3| 7| 5| 7| 7| 8| 8| 8| 4| 3| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pars Distalis, Hyperplasia           |                                                    3        3            |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia, Focal           |                            3                                         3   |             
      C-Cell, Hyperplasia, Multifocal      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       |                                        +                                 |             
      Inflammation, Chronic Active         |                                        3                                 |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Ectasia                              |                                                             3            |             
      Fibrosis                             |                                                             2            |             
      Serosa, Granuloma, Multifocal        |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              | 2                                                                        |             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         |                                           2                       2      |             
      Inflammation, Granulomatous          | 2  1  1  2        2  2     2     1     2     2  2  1  2     2  2     2  2|             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                                          |             
      Hemorrhage, Acute                    |                                                                          |             
      Hyperplasia, Focal                   |    1                       1                                             |             
      Hyperplasia, Multifocal              |                1              2                                          |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         |                2                          2              4           2   |             
      Inflammation, Chronic Active,        |                                                                          |             
          Suppurative                      |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Concretion                           |                                                                          |             
      Ectasia                              |                                                             2            |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization, Multifocal           |    2                             2                                       |             
      Artery, Inflammation, Chronic        |                                        2                                 |             
      Artery, Inflammation, Chronic Active,|                                                                          |             
           Multifocal                      |                                                                          |             
      Interstitial Cell, Hyperplasia       |                                  1  3     1                       1      |             
      Seminiferous Tubule, Atrophy         |                                  2  2     2              3  3           4|             
      Seminiferous Tubule, Degeneration    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  44                                                               
NTP Experiment-Test: 05072-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:30:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 4| 6| 2| 6| 7| 6| 7| 7| 6| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 6| 6| 7| 6|             
                             DAY ON TEST   | 2| 6| 2| 5| 9| 4| 2| 4| 0| 2| 4| 2| 8| 0| 2| 2| 4| 2| 2| 2| 2| 1| 4| 2| 1|             
                                           | 7| 3| 2| 8| 4| 4| 4| 6| 7| 7| 9| 7| 6| 8| 3| 7| 5| 7| 7| 8| 8| 8| 4| 3| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Serosa, Necrosis, Focal              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 3                    3                             3  3  2  3           3|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mediastinal, Hemorrhage, Acute       |                         4     2                                          |             
      Mediastinal, Hemorrhage, Subacute    |                                                                          |             
      Mediastinal, Hyperplasia, Re Cell    |                                                                          |             
      Pancreatic, Edema                    |                      3                                                   |             
      Pancreatic, Hemorrhage, Acute        |                                           3                              |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage, Acute                    |                                                                         3|             
      Hyperplasia, Plasma Cell             |    3                    2           4                                    |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hemorrhage, Acute                    |                                                                      2  2|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Hyperplasia, Re Cell                 |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Depletion Lymphoid                   |                                                                      3   |             
      Fibrosis, Focal                      | 4                                                           3           2|             
      Fibrosis, Multifocal                 |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia, Focal, Re Cell          |                                                                          |             
      Infarct                              |                                                                          |             
      Pigmentation, Hemosiderin            |             3           2                                                |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  M  +  A  +  +  +  M  M  +  M  M  +  +  M  +  M  +  +  +  +  +  M  +|             
      Ectopic Parathyroid Gland            |                                                                          |             
      Epithelial Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  M  +  +  M  +  +  +  +  +  M  +  +  M  M  +  M  +  +  +  +  +  +  M  +|             
      Ectasia, Diffuse                     |                         2                                                |             
      Ectasia, Multifocal                  |       2                                                           3      |             
      Hyperplasia, Diffuse                 |                                                          2               |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |                                                                2         |             
      Tail, Subcutaneous Tissue,           |                                                                          |             
          Inflammation, Chronic,           |                                                                          |             
          Proliferative                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  45                                                               
NTP Experiment-Test: 05072-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:30:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 4| 6| 2| 6| 7| 6| 7| 7| 6| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 6| 6| 7| 6|             
                             DAY ON TEST   | 2| 6| 2| 5| 9| 4| 2| 4| 0| 2| 4| 2| 8| 0| 2| 2| 4| 2| 2| 2| 2| 1| 4| 2| 1|             
                                           | 7| 3| 2| 8| 4| 4| 4| 6| 7| 7| 9| 7| 6| 8| 3| 7| 5| 7| 7| 8| 8| 8| 4| 3| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
      Necrosis, Acute                      |                                     4                                    |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          | X     X              X                 X                          X      |             
      Hemorrhage, Multifocal               |                                                 4                        |             
      Hydrocephalus                        |                                                                   2      |             
      Necrosis, Focal                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                                       1                  |             
      Inflammation, Chronic                | 1                                                           2            |             
      Inflammation, Chronic Active         |                                                 3     1        2  1  2   |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute, Multifocal      |                               4                 1                        |             
      Metaplasia, Focal, Osseous           |                                                                          |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                                                          |             
      Bronchiole, Hyperplasia              |                                                                         2|             
      Bronchus, Alveolus, Inflammation,    |                                                                          |             
           Chronic Active, Multifocal      |                                                                          |             
      Interstitium, Inflammation, Chronic, |                                                                          |             
           Multifocal                      |                                  4                                       |             
      Interstitium, Inflammation, Chronic  |                                                                          |             
          Active, Multifocal               |                                                          2               |             
      Peribronchiolar, Perivascular,       |                                                                          |             
          Granuloma, Multifocal            |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  A  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                                 3                    2   |             
      Mucosa, Inflammation, Chronic        |                                                       1                 2|             
      Mucosa, Inflammation, Chronic Active | 2                             2  1              2  2     3               |             
      Mucosa, Inflammation, Chronic Active,|                                                                          |             
           Suppurative                     |                                                                      3   |             
      Mucosa, Thrombosis, Multifocal       |                   2                          2                           |             
      Nasolacrimal Duct, Hyperplasia       |                                                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Acute, Suppurative              |                                                                      2   |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Chronic                         |                1                                            2            |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Chronic Active                  |                                                                          |             
      Olfactory Epithelium, Metaplasia     |                                                    2                 3  2|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  46                                                               
NTP Experiment-Test: 05072-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:30:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 4| 6| 2| 6| 7| 6| 7| 7| 6| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 6| 6| 7| 6|             
                             DAY ON TEST   | 2| 6| 2| 5| 9| 4| 2| 4| 0| 2| 4| 2| 8| 0| 2| 2| 4| 2| 2| 2| 2| 1| 4| 2| 1|             
                                           | 7| 3| 2| 8| 4| 4| 4| 6| 7| 7| 9| 7| 6| 8| 3| 7| 5| 7| 7| 8| 8| 8| 4| 3| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Respiratory Epithelium, Hyperplasia  |                               2                    2              1  4  1|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |             3                                                            |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |       +                                                                  |             
      Bilateral, Cornea, Mineralization,   |                                                                          |             
           Multifocal                      |       2                                                                  |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                   +      |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy, Chronic                 | 4  2  2  4     1  4  4  3  4  2  4  4  4  3  4  3  4  4  4  4  3  4  4  1|             
      Pigmentation, Diffuse                |    4           2                          2                              |             
      Pigmentation, Multifocal             |                                                                         3|             
      Bilateral, Hydronephrosis            |                                                          2               |             
      Cortex, Renal Tubule, Hyperplasia,   |                                                                          |             
           Atypical, Focal                 |                                              2                           |             
      Pelvis, Inflammation, Acute, Diffuse |                                        3                                 |             
      Pelvis, Transitional Epithelium,     |                                                                          |             
           Hyperplasia                     |                                        3                                 |             
                                            __________________________________________________________________________|             
   Ureter                                  |                                                          +               |             
      Inflammation, Chronic                |                                                          2               |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +|             
      Inflammation, Chronic, Diffuse       |                                        2                                 |             
      Inflammation, Chronic Active         |                                                                          |             
      Transitional Epithelium, Hyperplasia,|                                                                          |             
           Multifocal                      |                                        4                                 |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  47                                                               
NTP Experiment-Test: 05072-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:30:54  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 4| 6| 6| 6| 7| 5| 6| 7| 5| 7| 4| 6| 6| 6| 7| 6| 4| 7| 7| 7|            |
                             DAY ON TEST   | 2| 6| 2| 2| 2| 0| 4| 4| 6| 2| 4| 6| 2| 6| 2| 9| 7| 9| 0| 2| 5| 8| 2| 2| 2|            |
                                           | 8| 8| 8| 8| 9| 1| 4| 6| 1| 9| 6| 0| 7| 9| 7| 2| 1| 4| 4| 7| 3| 3| 0| 7| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Serosa, Hemorrhage, Chronic, Focal   |                         3                                                |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  M  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
      Inflammation, Chronic Active         |                                                             4            |      1  4.0|
      Parasite Metazoan                    |                               X                                   X  X   |      4     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Edema                                |                                  3                                       |      1  3.0|
      Parasite Metazoan                    |                                                                      X   |      3     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  M  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Parasite Metazoan                    |                            X                             X           X   |      4     |
      Serosa, Inflammation, Chronic        |    2                                                                     |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Infiltration Cellular, Eosinophil,   |                                                                          |            |
           Histiocyte                      |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Peyer's Patch, Hyperplasia, Lymphoid |                                                                         2|      1  2.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis, Focal                   |                                     1     2                              |      3  1.7|
      Angiectasis, Multifocal              |                                                                          |      1  3.0|
      Basophilic Focus                     | X                                X  X     X     X                    X   |      6     |
      Basophilic Focus, Multiple           |                                                                         X|      4     |
      Basophilic Focus, Two                |                                                          X               |      1     |
      Clear Cell Focus                     |                                                                          |      1  2.0|
      Congestion, Diffuse                  |                                                                          |      1  3.0|
      Cytomegaly, Diffuse                  |                                        3                                 |      1  3.0|
      Cytomegaly, Multifocal               |                                                             2            |      3  1.7|
      Degeneration, Ballooning, Focal      |                                                       1                  |      3  2.0|
      Degeneration, Ballooning, Multifocal |             3                                                            |      1  3.0|
      Eosinophilic Focus                   |             2                                                            |      1  2.0|
      Fatty Change, Diffuse                |                                                                          |      2  4.0|
      Fatty Change, Multifocal             |          1        2           1        2           2                 1   |      8  1.5|
      Fibrosis, Focal                      |       2                                                                  |      1  2.0|
      Granuloma, Multifocal                |                                                 1  1     1        2      |      6  1.2|
      Mitotic Alteration                   |                                                                          |      2  3.0|
      Necrosis, Acute, Multifocal          |                                                                          |      1  1.0|
      Vacuolization Cytoplasmic, Multifocal|                                                                         1|      3  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  48                                                               
NTP Experiment-Test: 05072-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:30:54  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 4| 6| 6| 6| 7| 5| 6| 7| 5| 7| 4| 6| 6| 6| 7| 6| 4| 7| 7| 7|            |
                             DAY ON TEST   | 2| 6| 2| 2| 2| 0| 4| 4| 6| 2| 4| 6| 2| 6| 2| 9| 7| 9| 0| 2| 5| 8| 2| 2| 2|            |
                                           | 8| 8| 8| 8| 9| 1| 4| 6| 1| 9| 6| 0| 7| 9| 7| 2| 1| 4| 4| 7| 3| 3| 0| 7| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Bile Duct, Hyperplasia, Multifocal   | 2     2     1           2  1  1  3     3  2  2     1        2     1  1   |     29  2.1|
      Centrilobular, Atrophy, Diffuse      |                                        2                                 |      2  2.5|
      Centrilobular, Atrophy, Multifocal   |                         2                                      3         |      4  2.3|
      Centrilobular, Fatty Change, Diffuse |                                                                          |      1  4.0|
      Centrilobular, Fatty Change,         |                                                                          |            |
          Multifocal                       |                         3                                                |      1  3.0|
      Centrilobular, Necrosis, Diffuse     |                                                                          |      1  3.0|
      Centrilobular, Necrosis, Multifocal  |                                                                          |      1  4.0|
      Median Lobe, Hepatodiaphragmatic     |                                                                          |            |
          Nodule                           | X                          X                                             |      2     |
      Periportal, Cytomegaly, Diffuse      |                                                                          |      1  3.0|
      Periportal, Fatty Change, Multifocal |    2                                                                     |      1  2.0|
      Portal, Fibrosis, Multifocal         |                                        3                                 |      2  2.0|
      Portal, Inflammation, Chronic,       |                                                                          |            |
          Multifocal                       |                                                                          |      1  1.0|
      Portal, Inflammation, Granulomatous, |                                                                          |            |
           Multifocal                      | 2                                                                        |      1  2.0|
      Serosa, Inflammation, Chronic Active,|                                                                          |            |
           Focal, Proliferative            |                   3                                                      |      1  3.0|
      Vein, Thrombosis                     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                         +     +           +                              |   4        |
      Pigmentation                         |                                                                          |      1  4.0|
      Fat, Necrosis, Focal                 |                               3                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Pigmentation                         |                                                                          |      1  4.0|
      Acinus, Atrophy, Focal               |                                                          2               |      1  2.0|
      Acinus, Atrophy, Multifocal          |    2  1           3  3  3              4        3           2     3      |     18  2.4|
      Artery, Adventitia, Inflammation,    |                                                                          |            |
           Chronic Active, Multifocal      |                                                             3            |      1  3.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic, Focal         |                                                                          |      1  2.0|
      Parotid Gland, Inflammation, Chronic |                                                                          |            |
          Active, Diffuse                  |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Acute, Focal           |                                                                          |      1  3.0|
      Inflammation, Chronic                |                      2                                                   |      2  2.0|
      Inflammation, Chronic Active         |                         2                                                |      3  3.0|
      Ulcer                                |                   4                                                      |      4  3.8|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  49                                                               
NTP Experiment-Test: 05072-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:30:54  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 4| 6| 6| 6| 7| 5| 6| 7| 5| 7| 4| 6| 6| 6| 7| 6| 4| 7| 7| 7|            |
                             DAY ON TEST   | 2| 6| 2| 2| 2| 0| 4| 4| 6| 2| 4| 6| 2| 6| 2| 9| 7| 9| 0| 2| 5| 8| 2| 2| 2|            |
                                           | 8| 8| 8| 8| 9| 1| 4| 6| 1| 9| 6| 0| 7| 9| 7| 2| 1| 4| 4| 7| 3| 3| 0| 7| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Epithelium, Hyperplasia, Diffuse     |                   4     2                                                |      5  2.6|
      Epithelium, Hyperplasia, Focal       |                      2                                                   |      1  2.0|
      Muscularis, Hyperplasia, Focal       |                                  2                                       |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Inflammation, Chronic                |                      2                                                   |      1  2.0|
      Mucosa, Necrosis, Acute, Multifocal  |                   2                                                      |      1  2.0|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   2        |
      Epithelium, Hyperplasia, Focal       |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
      Abscess                              |                                                                          |      1  4.0|
      Developmental Malformation           |                                                                          |      1  4.0|
      Gingiva, Inflammation                |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                  +                                       |   2        |
      Inflammation, Chronic, Focal,        |                                                                          |            |
          Necrotizing                      |                                                                          |      1  2.0|
      Mineralization, Focal                |                                  3                                       |      1  3.0|
      Intima, Fibrosis, Multifocal         |                                  3                                       |      1  3.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       | 4  3  3  2  3  1  2  2  2  1     1  2     3     2  3  2  4        2  2  2|     45  2.3|
      Atrium Left, Thrombosis              |                                                                          |      2  3.5|
      Myocardium, Inflammation, Chronic,   |                                                                          |            |
           Focal                           |                                                                         2|      1  2.0|
      Ventricle Left, Dilatation           |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Capsule, Accessory Adrenal Cortical  |                                                                          |            |
          Nodule                           |                                                 X                        |      4     |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Degeneration, Diffuse, Fatty         |                                                                          |      3  2.7|
      Degeneration, Fatty, Focal           |             2              1        1        1  2     1        2         |     10  1.8|
      Degeneration, Fatty, Multifocal      |                                        2                                 |      3  2.3|
      Degeneration, Multifocal             |                                                                          |      1  2.0|
      Hyperplasia, Focal                   |                   2                             2                        |      6  1.8|
      Hyperplasia, Multifocal              |                                                                          |      1  2.0|
      Hypertrophy, Focal                   |                                                                          |      1  2.0|
      Necrosis, Acute, Focal               |                                        1                                 |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  50                                                               
NTP Experiment-Test: 05072-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:30:54  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 4| 6| 6| 6| 7| 5| 6| 7| 5| 7| 4| 6| 6| 6| 7| 6| 4| 7| 7| 7|            |
                             DAY ON TEST   | 2| 6| 2| 2| 2| 0| 4| 4| 6| 2| 4| 6| 2| 6| 2| 9| 7| 9| 0| 2| 5| 8| 2| 2| 2|            |
                                           | 8| 8| 8| 8| 9| 1| 4| 6| 1| 9| 6| 0| 7| 9| 7| 2| 1| 4| 4| 7| 3| 3| 0| 7| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Hyperplasia, Focal                   |       1  2              3                          1                     |      7  1.4|
      Hyperplasia, Multifocal              | 3                             1  2                          1            |      9  2.0|
      Necrosis, Acute, Focal               |                                        1                                 |      1  1.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia, Focal                   |                                                                      2   |      2  2.5|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Hyperplasia, Diffuse                 |                                                                          |      3  2.7|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  49        |
      Pars Distalis, Angiectasis           |                                                                          |      2  3.0|
      Pars Distalis, Cyst                  |             1                                                            |      1  1.0|
      Pars Distalis, Cyst, Multiple        |                      2                                                   |      1  2.0|
      Pars Distalis, Developmental         |                                                                          |            |
          Malformation                     |                                                                         X|      1     |
      Pars Distalis, Hyperplasia, Focal    |                                                                          |      1  3.0|
      Pars Distalis, Hyperplasia           | 3                                                        1               |      4  2.5|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      C-Cell, Hyperplasia, Focal           |    2                                                                     |      3  2.7|
      C-Cell, Hyperplasia, Multifocal      |             1                 2                                          |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Coagulating Gland                       |                                                                          |   1        |
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Atrophy                              |                                        2  3                              |      2  2.5|
      Ectasia                              |                                                                          |      1  3.0|
      Fibrosis                             |                                                                          |      1  2.0|
      Serosa, Granuloma, Multifocal        | 3                                                                        |      1  3.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Ectasia                              |             3                 4                                          |      3  3.0|
      Hyperplasia                          |       1                                                                  |      1  1.0|
      Inflammation, Chronic                |       1                                                                  |      1  1.0|
      Inflammation, Chronic Active         |             2                                                            |      3  2.0|
      Inflammation, Granulomatous          | 2  2                 2  2  2           1  2     2           2        3  3|     28  1.9|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Abscess                              |                2                                                         |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  51                                                               
NTP Experiment-Test: 05072-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:30:54  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 4| 6| 6| 6| 7| 5| 6| 7| 5| 7| 4| 6| 6| 6| 7| 6| 4| 7| 7| 7|            |
                             DAY ON TEST   | 2| 6| 2| 2| 2| 0| 4| 4| 6| 2| 4| 6| 2| 6| 2| 9| 7| 9| 0| 2| 5| 8| 2| 2| 2|            |
                                           | 8| 8| 8| 8| 9| 1| 4| 6| 1| 9| 6| 0| 7| 9| 7| 2| 1| 4| 4| 7| 3| 3| 0| 7| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Hemorrhage, Acute                    |                                                          3               |      1  3.0|
      Hyperplasia, Focal                   | 2  1                                                  4                 4|      6  2.2|
      Hyperplasia, Multifocal              |       2                             3                                    |      4  2.0|
      Inflammation, Chronic                |                                                    3                     |      1  3.0|
      Inflammation, Chronic Active         |                                                             4            |      5  2.8|
      Inflammation, Chronic Active,        |                                                                          |            |
          Suppurative                      |                   3                                                      |      1  3.0|
      Inflammation, Suppurative            |                               4                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  M  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Concretion                           |                               2                                          |      1  2.0|
      Ectasia                              |    3                                                                     |      2  2.5|
      Hyperplasia                          |             2                                                            |      1  2.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mineralization, Multifocal           |                1        2                                                |      4  1.8|
      Artery, Inflammation, Chronic        |                                                                          |      1  2.0|
      Artery, Inflammation, Chronic Active,|                                                                          |            |
           Multifocal                      |                            2                                             |      1  2.0|
      Interstitial Cell, Hyperplasia       |    1                    1                 2                 1  2         |      9  1.4|
      Seminiferous Tubule, Atrophy         |             4           2                 4     1                 2     3|     12  2.7|
      Seminiferous Tubule, Degeneration    |                   2                    3                                 |      2  2.5|
      Serosa, Necrosis, Focal              |                            2                                             |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          | 3           4  3        2        2                                       |     12  2.8|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mediastinal, Hemorrhage, Acute       |                                  3                                       |      3  3.0|
      Mediastinal, Hemorrhage, Subacute    |                                                                   2  2   |      2  2.0|
      Mediastinal, Hyperplasia, Re Cell    |                         4                                                |      1  4.0|
      Pancreatic, Edema                    |                                                                          |      1  3.0|
      Pancreatic, Hemorrhage, Acute        |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  48        |
      Hemorrhage, Acute                    |                                                                          |      1  3.0|
      Hyperplasia, Plasma Cell             |                                           3     3        2           2   |      7  2.7|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Cyst                                 |                                  3                                       |      1  3.0|
      Hemorrhage, Acute                    |          2                                      2                        |      4  2.0|
      Hyperplasia, Lymphoid                |                                                          2               |      1  2.0|
      Hyperplasia, Re Cell                 |                2                                                         |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  52                                                               
NTP Experiment-Test: 05072-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:30:54  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 4| 6| 6| 6| 7| 5| 6| 7| 5| 7| 4| 6| 6| 6| 7| 6| 4| 7| 7| 7|            |
                             DAY ON TEST   | 2| 6| 2| 2| 2| 0| 4| 4| 6| 2| 4| 6| 2| 6| 2| 9| 7| 9| 0| 2| 5| 8| 2| 2| 2|            |
                                           | 8| 8| 8| 8| 9| 1| 4| 6| 1| 9| 6| 0| 7| 9| 7| 2| 1| 4| 4| 7| 3| 3| 0| 7| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Depletion Lymphoid                   |                                                                          |      1  3.0|
      Fibrosis, Focal                      |                                        2                             4   |      5  3.0|
      Fibrosis, Multifocal                 |                                                          2               |      1  2.0|
      Hematopoietic Cell Proliferation     |                3                 2                                       |      2  2.5|
      Hyperplasia, Focal, Re Cell          |                                                                      3   |      1  3.0|
      Infarct                              |                                                             4            |      1  4.0|
      Pigmentation, Hemosiderin            |    2              2                                                      |      4  2.3|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  M  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +   |  36        |
      Ectopic Parathyroid Gland            |                                                                   X      |      1     |
      Epithelial Cell, Hyperplasia         |                                                                      2   |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  43        |
      Ectasia, Diffuse                     |                               4           3                          2   |      4  2.8|
      Ectasia, Multifocal                  |    3     1        3     1  2           3        2     1           3      |     11  2.2|
      Hyperplasia, Diffuse                 |                                                                         1|      2  1.5|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperkeratosis                       |                                                                          |      1  2.0|
      Tail, Subcutaneous Tissue,           |                                                                          |            |
          Inflammation, Chronic,           |                                                                          |            |
          Proliferative                    |                                                          4               |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Necrosis, Acute                      |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                               +                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression                          |    X     X                 X  X           X     X  X  X           X      |     14     |
      Hemorrhage, Multifocal               |                                                                          |      1  4.0|
      Hydrocephalus                        |    3     1                                      3  3  2                  |      6  2.3|
      Necrosis, Focal                      |                                                             1            |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Foreign Body                         |                                                                2         |      2  1.5|
      Inflammation, Chronic                | 2                                                                       2|      4  1.8|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  53                                                               
NTP Experiment-Test: 05072-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:30:54  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 4| 6| 6| 6| 7| 5| 6| 7| 5| 7| 4| 6| 6| 6| 7| 6| 4| 7| 7| 7|            |
                             DAY ON TEST   | 2| 6| 2| 2| 2| 0| 4| 4| 6| 2| 4| 6| 2| 6| 2| 9| 7| 9| 0| 2| 5| 8| 2| 2| 2|            |
                                           | 8| 8| 8| 8| 9| 1| 4| 6| 1| 9| 6| 0| 7| 9| 7| 2| 1| 4| 4| 7| 3| 3| 0| 7| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Chronic Active         |                                                    1     2     2  2      |      9  1.8|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Acute, Multifocal      |                                                                          |      2  2.5|
      Metaplasia, Focal, Osseous           | 2                                                                        |      1  2.0|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |                                                 1                        |      1  1.0|
      Bronchiole, Hyperplasia              |                                                                          |      1  2.0|
      Bronchus, Alveolus, Inflammation,    |                                                                          |            |
           Chronic Active, Multifocal      |                      3                                                   |      1  3.0|
      Interstitium, Inflammation, Chronic, |                                                                          |            |
           Multifocal                      |                                                                          |      1  4.0|
      Interstitium, Inflammation, Chronic  |                                                                          |            |
          Active, Multifocal               |                                                                          |      1  2.0|
      Peribronchiolar, Perivascular,       |                                                                          |            |
          Granuloma, Multifocal            | 2                                                                        |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Foreign Body                         |                               2                                          |      3  2.3|
      Mucosa, Inflammation, Chronic        |                                                                          |      2  1.5|
      Mucosa, Inflammation, Chronic Active |       1                       2                                         3|      9  2.0|
      Mucosa, Inflammation, Chronic Active,|                                                                          |            |
           Suppurative                     |                                                                          |      1  3.0|
      Mucosa, Thrombosis, Multifocal       |                                                                          |      2  2.0|
      Nasolacrimal Duct, Hyperplasia       | 3                                                                        |      1  3.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Acute, Suppurative              |                   2                             1                        |      3  1.7|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Chronic                         |                                                                          |      2  1.5|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Chronic Active                  | 4                                                                        |      1  4.0|
      Olfactory Epithelium, Metaplasia     |                                                                          |      3  2.3|
      Respiratory Epithelium, Hyperplasia  |                                                       1                 2|      7  1.9|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
      Bilateral, Cornea, Mineralization,   |                                                                          |            |
           Multifocal                      |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  54                                                               
NTP Experiment-Test: 05072-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:30:54  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 4| 6| 6| 6| 7| 5| 6| 7| 5| 7| 4| 6| 6| 6| 7| 6| 4| 7| 7| 7|            |
                             DAY ON TEST   | 2| 6| 2| 2| 2| 0| 4| 4| 6| 2| 4| 6| 2| 6| 2| 9| 7| 9| 0| 2| 5| 8| 2| 2| 2|            |
                                           | 8| 8| 8| 8| 9| 1| 4| 6| 1| 9| 6| 0| 7| 9| 7| 2| 1| 4| 4| 7| 3| 3| 0| 7| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Nephropathy, Chronic                 | 4  4  3  4  3     4  2  4  4  4     4  3  4  2  4  4  3  4  3  1  4  4  4|     47  3.4|
      Pigmentation, Diffuse                |                                        2                                 |      4  2.5|
      Pigmentation, Multifocal             |                                                                          |      1  3.0|
      Bilateral, Hydronephrosis            |                                                                          |      1  2.0|
      Cortex, Renal Tubule, Hyperplasia,   |                                                                          |            |
           Atypical, Focal                 |                                           1                              |      2  1.5|
      Pelvis, Inflammation, Acute, Diffuse |                                                                          |      1  3.0|
      Pelvis, Transitional Epithelium,     |                                                                          |            |
           Hyperplasia                     |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Ureter                                  |                                                                          |   1        |
      Inflammation, Chronic                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Chronic, Diffuse       |                                                                          |      1  2.0|
      Inflammation, Chronic Active         |                         2                                                |      1  2.0|
      Transitional Epithelium, Hyperplasia,|                                                                          |            |
           Multifocal                      |                                                                          |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  55                                                               
NTP Experiment-Test: 05072-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:30:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 5| 7| 6| 5| 6| 5| 5| 6| 5| 7| 6| 5| 5| 5| 6| 5| 6| 6| 7| 5| 5| 5| 6|             
                             DAY ON TEST   | 2| 2| 4| 0| 5| 0| 7| 4| 9| 0| 7| 2| 5| 0| 4| 6| 8| 1| 3| 9| 2| 4| 4| 4| 0|             
                                           | 9| 8| 9| 8| 7| 0| 4| 7| 0| 9| 3| 8| 9| 6| 1| 2| 5| 3| 2| 4| 3| 6| 7| 8| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    5 PPM                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Edema                                |                                                    3                     |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |    X              X     X           X                       X           X|             
      Muscularis, Mineralization,          |                                                                          |             
          Multifocal                       |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |       X                                                                  |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectopic Tissue                       |                X                                                         |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  M  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mucosa, Atrophy, Diffuse             |                               3                                          |             
      Peyer's Patch, Hyperplasia, Lymphoid |                                           2                              |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                    4                     |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis, Focal                   |                                                                          |             
      Basophilic Focus                     |                                     X                                    |             
      Basophilic Focus, Multiple           |    X           X           X                                         X   |             
      Basophilic Focus, Two                |                         X        X           X              X            |             
      Congestion, Diffuse                  |                      2                                                   |             
      Degeneration, Ballooning, Focal      |                                     2                                    |             
      Fatty Change, Diffuse                |                                                                          |             
      Fatty Change, Multifocal             |                                                 1                        |             
      Granuloma, Multifocal                |          2                                                               |             
      Mitotic Alteration                   |                                                                      2   |             
      Necrosis, Acute, Multifocal          |                            2        1                             2      |             
      Bile Duct, Hyperplasia, Multifocal   | 2  1  3  1  1  1  1        1  3  1  3     2     1  2     1  1           3|             
      Centrilobular, Atrophy, Diffuse      |                                                                          |             
      Centrilobular, Atrophy, Multifocal   |       2                       2     2           2                        |             
      Centrilobular, Congestion            |                            3                                             |             
      Centrilobular, Degeneration, Diffuse |                                                                          |             
      Centrilobular, Degeneration,         |                                                                          |             
          Multifocal                       |                                                                          |             
      Centrilobular, Fatty Change, Diffuse |                                                                          |             
      Centrilobular, Fatty Change,         |                                                                          |             
          Multifocal                       |                                                                          |             
      Median Lobe, Hepatodiaphragmatic     |                                                                          |             
          Nodule                           |                                                                          |             
      Portal, Fibrosis, Multifocal         | 2                 1                                1                     |             
      Vein, Thrombosis                     |                                                                         X|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  56                                                               
NTP Experiment-Test: 05072-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:30:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 5| 7| 6| 5| 6| 5| 5| 6| 5| 7| 6| 5| 5| 5| 6| 5| 6| 6| 7| 5| 5| 5| 6|             
                             DAY ON TEST   | 2| 2| 4| 0| 5| 0| 7| 4| 9| 0| 7| 2| 5| 0| 4| 6| 8| 1| 3| 9| 2| 4| 4| 4| 0|             
                                           | 9| 8| 9| 8| 7| 0| 4| 7| 0| 9| 3| 8| 9| 6| 1| 2| 5| 3| 2| 4| 3| 6| 7| 8| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    5 PPM                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |       +     +                                                     +  +   |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |                                                                   2      |             
      Inflammation, Subacute               |             2                                                            |             
      Artery, Mineralization               |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis, Focal                   |                                                                          |             
      Fibrosis, Focal                      |                                                                          |             
      Acinus, Atrophy, Focal               |                                                                          |             
      Acinus, Atrophy, Multifocal          |    2           1  2           3  3     3  2        3     2  3  2         |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Duct, Inflammation, Chronic Active,  |                                                                          |             
           Multifocal                      |                                           2                              |             
      Duct, Metaplasia, Multifocal,        |                                                                          |             
          Squamous                         |                                           2                              |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis, Multifocal           |                                                          2               |             
      Inflammation, Acute, Focal           | 2                                                                        |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         |                                           2              2               |             
      Ulcer                                |                                                          2               |             
      Epithelium, Hyperplasia, Diffuse     |                                                                          |             
      Epithelium, Hyperplasia, Focal       |                      2                                                   |             
      Epithelium, Hyperplasia, Multifocal  |                                                    3                     |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Mucosa, Mineralization               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
      Pulmonary Artery, Mineralization     |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 2  3  2  2  2     2     1  2  2  3  2  1  2  1           2  3            |             
      Inflammation, Chronic Active, Focal  |                         2                                                |             
      Mineralization                       |                                                                          |             
      Atrium Left, Thrombosis              |                               4                                          |             
      Atrium Right, Dilatation             |          4                                                               |             
      Epicardium, Hyperplasia              |                                        4                                 |             
      Epicardium, Inflammation, Chronic,   |                                                                          |             
           Focal                           |             3                                                            |             
      Mitral Valve, Inflammation, Chronic  |                                        2                                 |             
      Ventricle Left, Hypertrophy, Focal   |             3                                                            |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  57                                                               
NTP Experiment-Test: 05072-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:30:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 5| 7| 6| 5| 6| 5| 5| 6| 5| 7| 6| 5| 5| 5| 6| 5| 6| 6| 7| 5| 5| 5| 6|             
                             DAY ON TEST   | 2| 2| 4| 0| 5| 0| 7| 4| 9| 0| 7| 2| 5| 0| 4| 6| 8| 1| 3| 9| 2| 4| 4| 4| 0|             
                                           | 9| 8| 9| 8| 7| 0| 4| 7| 0| 9| 3| 8| 9| 6| 1| 2| 5| 3| 2| 4| 3| 6| 7| 8| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    5 PPM                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Capsule, Accessory Adrenal Cortical  |                                                                          |             
          Nodule                           |    X  X                                                                  |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Congestion                           |                                                                   2      |             
      Degeneration, Diffuse, Fatty         | 1     1              2        2                 3     1                  |             
      Degeneration, Fatty, Focal           |                                                                          |             
      Degeneration, Fatty, Multifocal      |                                  2           1           2  2            |             
      Hyperplasia, Focal                   |                               1     1                                    |             
      Hyperplasia, Multifocal              |             2                                                            |             
      Hypertrophy, Focal                   |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  M  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +   |             
      Hyperplasia, Focal                   |             2                                                            |             
      Hyperplasia, Multifocal              |                         1        2              3        4  2            |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                   2        4                                             |             
      Hyperplasia                          |                                                                          |             
      Hyperplasia, Multifocal              | 3                                                                        |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  M  +  +  M  +  +  +  M  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Diffuse                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Fibrosis, Focal                      |                                                                          |             
      Necrosis, Subacute                   |                                           4                              |             
      Pars Distalis, Angiectasis           |                                                                          |             
      Pars Distalis, Cyst                  |                                                       2                  |             
      Pars Distalis, Cyst, Multiple        |                                                                          |             
      Pars Distalis, Hyperplasia, Focal    |          2                 2                                             |             
      Pars Distalis, Hyperplasia,          |                                                                          |             
          Multifocal                       |                         2                                                |             
      Pars Distalis, Hypertrophy, Focal    |    2                                                                     |             
      Pars Intermedia, Angiectasis,        |                                                                          |             
          Multifocal                       |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia, Focal           |       2     1     3                                                      |             
      C-Cell, Hyperplasia, Multifocal      |                                     1                                    |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              | +                                                                        |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                                   3      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  58                                                               
NTP Experiment-Test: 05072-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:30:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 5| 7| 6| 5| 6| 5| 5| 6| 5| 7| 6| 5| 5| 5| 6| 5| 6| 6| 7| 5| 5| 5| 6|             
                             DAY ON TEST   | 2| 2| 4| 0| 5| 0| 7| 4| 9| 0| 7| 2| 5| 0| 4| 6| 8| 1| 3| 9| 2| 4| 4| 4| 0|             
                                           | 9| 8| 9| 8| 7| 0| 4| 7| 0| 9| 3| 8| 9| 6| 1| 2| 5| 3| 2| 4| 3| 6| 7| 8| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    5 PPM                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Atrophy                              |                                                          3               |             
      Cyst                                 |                                                                          |             
      Ectasia                              |             3                                      4                     |             
      Hyperplasia                          |                                                                          |             
      Inflammation, Granulomatous          | 3  2  3     2     3  3     3  2        2     2  2              2  2  2  2|             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  A  +  +|             
      Abscess                              |                                                                          |             
      Ectasia, Focal                       |                                                                          |             
      Hyperplasia, Focal                   |                   2        1                 1                           |             
      Hyperplasia, Multifocal              |    3                                                           1         |             
      Inflammation, Chronic                |                                     2                                    |             
      Inflammation, Chronic Active         |                               3                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization, Focal                |                                                 2                        |             
      Mineralization, Multifocal           |                                                                   2      |             
      Artery, Inflammation, Chronic        |                                                                          |             
      Interstitial Cell, Hyperplasia       |       1           3  1  4     1        2     2  1  2     2     1         |             
      Seminiferous Tubule, Atrophy         |                               3  3                                3  4  3|             
      Seminiferous Tubule, Degeneration    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Hyperplasia                          |             2                          2        3                    3   |             
      Myeloid Cell, Hyperplasia            |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mediastinal, Cyst                    |    4                                                                     |             
      Mediastinal, Cyst, Multiple          |                                              3                           |             
      Mediastinal, Hemorrhage, Acute       |                      3                                2                  |             
      Mediastinal, Hemorrhage, Subacute    |                                  3           1                           |             
      Mediastinal, Hyperplasia             |                                                                   3      |             
      Mediastinal, Pigmentation            |                                                                          |             
      Pancreatic, Hemorrhage, Acute        |             2                                                            |             
      Pancreatic, Hyperplasia              |                                                             3            |             
      Renal, Hemorrhage, Acute             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +|             
      Hemorrhage, Acute                    |                                                                          |             
      Hemorrhage, Subacute                 |                                                                          |             
      Hyperplasia                          |                                                                          |             
      Hyperplasia, Plasma Cell             |                                                                          |             
      Inflammation, Chronic Active         |             3                                                            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +|             
      Cyst                                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  59                                                               
NTP Experiment-Test: 05072-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:30:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 5| 7| 6| 5| 6| 5| 5| 6| 5| 7| 6| 5| 5| 5| 6| 5| 6| 6| 7| 5| 5| 5| 6|             
                             DAY ON TEST   | 2| 2| 4| 0| 5| 0| 7| 4| 9| 0| 7| 2| 5| 0| 4| 6| 8| 1| 3| 9| 2| 4| 4| 4| 0|             
                                           | 9| 8| 9| 8| 7| 0| 4| 7| 0| 9| 3| 8| 9| 6| 1| 2| 5| 3| 2| 4| 3| 6| 7| 8| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    5 PPM                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hemorrhage, Acute                    |             3        2           2           1                           |             
      Hyperplasia, Lymphoid                |                                                                   2      |             
      Hyperplasia, Re Cell                 |          3                                                               |             
      Inflammation, Subacute               |                                                    3                     |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion, Acute                    |                                                                   4      |             
      Depletion Lymphoid                   |                                                    2                     |             
      Fibrosis, Diffuse                    |                                                                         4|             
      Fibrosis, Focal                      |                                                             3            |             
      Hematopoietic Cell Proliferation     |             2                    2              2                    2   |             
      Necrosis, Multifocal, Subacute       |                                                                          |             
      Pigmentation, Hemosiderin            |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  M  +  +  M  +  +  +  +  +  +|             
      Ectopic Parathyroid Gland            |                                                                          |             
      Epithelial Cell, Hyperplasia         |                                           2                              |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  M  +  +|             
      Ectasia, Diffuse                     |                                                                          |             
      Ectasia, Multifocal                  |    2                                2           3                        |             
      Hyperplasia, Diffuse                 |                      2                             2                     |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Dermoid                         |                                                                          |             
      Inflammation, Chronic Active, Focal, |                                                                          |             
           Suppurative                     |                                                                          |             
      Tail, Inflammation, Chronic          |    3                                                                     |             
      Tail, Epithelium, Hyperplasia        |    2                                                                     |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                                                 X                        |             
      Hemorrhage, Multifocal               |                                                                          |             
      Hydrocephalus                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |                                           2                              |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  60                                                               
NTP Experiment-Test: 05072-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:30:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 5| 7| 6| 5| 6| 5| 5| 6| 5| 7| 6| 5| 5| 5| 6| 5| 6| 6| 7| 5| 5| 5| 6|             
                             DAY ON TEST   | 2| 2| 4| 0| 5| 0| 7| 4| 9| 0| 7| 2| 5| 0| 4| 6| 8| 1| 3| 9| 2| 4| 4| 4| 0|             
                                           | 9| 8| 9| 8| 7| 0| 4| 7| 0| 9| 3| 8| 9| 6| 1| 2| 5| 3| 2| 4| 3| 6| 7| 8| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    5 PPM                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Abscess                              |                                                                          |             
      Hemorrhage, Acute, Focal             |                                                                          |             
      Hemorrhage, Acute, Multifocal        |                2                                                         |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Histiocyte                      |                                                                          |             
      Necrosis, Acute, Multifocal          |                                                 4                        |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Multifocal                      | 4  4  3  4  4  4  3  4  4  4  4  4  4  2  3  3  4  4  4  4  3  4  4  4  4|             
      Artery, Mediastinum, Mineralization  |                                                                          |             
      Bronchiole, Hyperplasia, Multifocal  | 4  4  3  4  4  4  3  4  4  4  4  4  4        3  4  4  4  4  3  4  4  4   |             
      Bronchus, Metaplasia, Squamous       | 2                                                                        |             
      Interstitium, Inflammation, Chronic, |                                                                          |             
           Multifocal                      |                                                                          |             
      Interstitium, Mineralization,        |                                                                          |             
          Multifocal                       |                                                                          |             
      Mediastinum, Angiectasis             |                                                                          |             
      Mediastinum, Cyst                    |             4                                                            |             
      Mediastinum, Pigmentation            |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |             2                                            2               |             
      Lumen, Exudate                       |                                                                          |             
      Mucosa, Inflammation, Chronic Active |    1  1  1        1              1                          2           2|             
      Mucosa, Inflammation, Chronic Active,|                                                                          |             
           Suppurative                     | 2           4        2  3     2     3  2     2  3     2  3           2   |             
      Mucosa, Thrombosis, Multifocal       |                                                 2                        |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Chronic                         |                                           1                              |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Chronic Active                  |                                                                          |             
      Olfactory Epithelium, Atrophy        |                                  2                 1                    2|             
      Respiratory Epithelium, Hyperplasia  |          1  1     2  1  1     2  1  1  1     1  2     2  3  1           2|             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |             3                       2        1  2        2  2           2|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                           2                              |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
      Bilateral, External Ear,             |                                                                          |             
          Hyperkeratosis                   |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                        +                                 |             
      Lens, Cataract                       |                                                                          |             
      Retina, Degeneration                 |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                              +                           |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  61                                                               
NTP Experiment-Test: 05072-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:30:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 5| 7| 6| 5| 6| 5| 5| 6| 5| 7| 6| 5| 5| 5| 6| 5| 6| 6| 7| 5| 5| 5| 6|             
                             DAY ON TEST   | 2| 2| 4| 0| 5| 0| 7| 4| 9| 0| 7| 2| 5| 0| 4| 6| 8| 1| 3| 9| 2| 4| 4| 4| 0|             
                                           | 9| 8| 9| 8| 7| 0| 4| 7| 0| 9| 3| 8| 9| 6| 1| 2| 5| 3| 2| 4| 3| 6| 7| 8| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    5 PPM                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Inflammation, Chronic Active         |                                              4                           |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst, Two                            |                                                       3                  |             
      Infarct                              |                                                                          |             
      Nephropathy, Chronic                 | 3  2  1  2  3     4  2  3  3  1  3  4  1  3  3  4  2  2  4  3  1  2  2  3|             
      Pigmentation, Diffuse                |                                                                      4   |             
      Pigmentation, Multifocal             |                               2                                          |             
      Cortex, Renal Tubule, Hyperplasia,   |                                                                          |             
           Atypical, Focal                 |                                                                          |             
      Proximal Convoluted Renal Tubule,    |                                                                          |             
           Necrosis, Acute                 |       2                                                                  |             
                                            __________________________________________________________________________|             
   Ureter                                  |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Inflammation, Chronic Active         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  62                                                               
NTP Experiment-Test: 05072-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:30:54  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 6| 6| 5| 6| 6| 4| 5| 6| 6| 6| 6| 7| 5| 5| 7| 6| 6| 7| 6| 6| 6| 5| 5|            |
                             DAY ON TEST   | 6| 0| 7| 3| 1| 1| 1| 9| 7| 5| 9| 7| 5| 2| 3| 2| 2| 9| 3| 1| 0| 0| 0| 4| 4|            |
                                           | 2| 6| 3| 2| 8| 0| 8| 7| 6| 3| 8| 4| 3| 8| 2| 1| 8| 6| 8| 0| 4| 5| 1| 8| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    5 PPM                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Edema                                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Parasite Metazoan                    |    X                                            X                        |      8     |
      Muscularis, Mineralization,          |                                                                          |            |
          Multifocal                       |                                                                         3|      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|  48        |
      Parasite Metazoan                    |    X                                            X                        |      3     |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Ectopic Tissue                       |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +     +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|  46        |
      Mucosa, Atrophy, Diffuse             |                                                                          |      1  3.0|
      Peyer's Patch, Hyperplasia, Lymphoid |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +     +  +  +  +  +  M  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|  45        |
      Congestion                           |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis, Focal                   |                                        2              3                  |      2  2.5|
      Basophilic Focus                     |    X                             X                                   X   |      4     |
      Basophilic Focus, Multiple           |                                                          X               |      5     |
      Basophilic Focus, Two                |             X                                   X                        |      6     |
      Congestion, Diffuse                  |    2                                                                     |      2  2.0|
      Degeneration, Ballooning, Focal      |                                                       4  2               |      3  2.7|
      Fatty Change, Diffuse                |          4                                                               |      1  4.0|
      Fatty Change, Multifocal             |                   2                          3                           |      3  2.0|
      Granuloma, Multifocal                |             2                                                           1|      3  1.7|
      Mitotic Alteration                   |                                                                          |      1  2.0|
      Necrosis, Acute, Multifocal          |                               2     2                       2            |      6  1.8|
      Bile Duct, Hyperplasia, Multifocal   |                3  1     3  3  4     2     1  2  4  1  3  1  2  3         |     31  2.0|
      Centrilobular, Atrophy, Diffuse      |                            3                                             |      1  3.0|
      Centrilobular, Atrophy, Multifocal   |                3                                            3            |      6  2.3|
      Centrilobular, Congestion            |                                                                          |      1  3.0|
      Centrilobular, Degeneration, Diffuse |                                                                   2      |      1  2.0|
      Centrilobular, Degeneration,         |                                                                          |            |
          Multifocal                       |                               3           2                              |      2  2.5|
      Centrilobular, Fatty Change, Diffuse |                                                                   4      |      1  4.0|
      Centrilobular, Fatty Change,         |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  63                                                               
NTP Experiment-Test: 05072-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:30:54  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 6| 6| 5| 6| 6| 4| 5| 6| 6| 6| 6| 7| 5| 5| 7| 6| 6| 7| 6| 6| 6| 5| 5|            |
                             DAY ON TEST   | 6| 0| 7| 3| 1| 1| 1| 9| 7| 5| 9| 7| 5| 2| 3| 2| 2| 9| 3| 1| 0| 0| 0| 4| 4|            |
                                           | 2| 6| 3| 2| 8| 0| 8| 7| 6| 3| 8| 4| 3| 8| 2| 1| 8| 6| 8| 0| 4| 5| 1| 8| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    5 PPM                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
          Multifocal                       |                                                          2               |      1  2.0|
      Median Lobe, Hepatodiaphragmatic     |                                                                          |            |
          Nodule                           |       X     X                                   X                        |      3     |
      Portal, Fibrosis, Multifocal         |                                                       1                 1|      5  1.2|
      Vein, Thrombosis                     |                      2                                                   |      2  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                           +                             +|   6        |
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |                                                                          |      1  2.0|
      Inflammation, Subacute               |                                                                          |      1  2.0|
      Artery, Mineralization               |                                                                         3|      1  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis, Focal                   |                                                                      3   |      1  3.0|
      Fibrosis, Focal                      |                                                          3               |      1  3.0|
      Acinus, Atrophy, Focal               |                            2                                             |      1  2.0|
      Acinus, Atrophy, Multifocal          |                                     3  2     2     2  2  3  3            |     18  2.4|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Duct, Inflammation, Chronic Active,  |                                                                          |            |
           Multifocal                      |                                                                          |      1  2.0|
      Duct, Metaplasia, Multifocal,        |                                                                          |            |
          Squamous                         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperkeratosis, Multifocal           |                                                                          |      1  2.0|
      Inflammation, Acute, Focal           |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                                       1                  |      1  1.0|
      Inflammation, Chronic Active         |          4     4                       2           2     3  2            |      8  2.6|
      Ulcer                                |          3     4                       2                                 |      4  2.8|
      Epithelium, Hyperplasia, Diffuse     |                                        2                                 |      1  2.0|
      Epithelium, Hyperplasia, Focal       |          3                                               2               |      3  2.3|
      Epithelium, Hyperplasia, Multifocal  |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                |                                        2                                 |      1  2.0|
      Mucosa, Mineralization               |                                                                         3|      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                       +                 +|   2        |
      Pulmonary Artery, Mineralization     |                                                                         3|      1  3.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       | 2  4  1  2     2  1  1        2  2  2  1     2  4  2  2  2     3  2  2  4|     36  2.1|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  64                                                               
NTP Experiment-Test: 05072-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:30:54  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 6| 6| 5| 6| 6| 4| 5| 6| 6| 6| 6| 7| 5| 5| 7| 6| 6| 7| 6| 6| 6| 5| 5|            |
                             DAY ON TEST   | 6| 0| 7| 3| 1| 1| 1| 9| 7| 5| 9| 7| 5| 2| 3| 2| 2| 9| 3| 1| 0| 0| 0| 4| 4|            |
                                           | 2| 6| 3| 2| 8| 0| 8| 7| 6| 3| 8| 4| 3| 8| 2| 1| 8| 6| 8| 0| 4| 5| 1| 8| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    5 PPM                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Chronic Active, Focal  |                                                                          |      1  2.0|
      Mineralization                       |                                                                         3|      1  3.0|
      Atrium Left, Thrombosis              |                                                                   4      |      2  4.0|
      Atrium Right, Dilatation             |    4                                                                     |      2  4.0|
      Epicardium, Hyperplasia              |                                  2              2                        |      3  2.7|
      Epicardium, Inflammation, Chronic,   |                                                                          |            |
           Focal                           |                                                                          |      1  3.0|
      Mitral Valve, Inflammation, Chronic  |                                                                          |      1  2.0|
      Ventricle Left, Hypertrophy, Focal   |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Capsule, Accessory Adrenal Cortical  |                                                                          |            |
          Nodule                           |    X  X                       X  X  X           X                        |      8     |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Congestion                           |                                                                          |      1  2.0|
      Degeneration, Diffuse, Fatty         |       3  2     2  3              2           2        2           2      |     14  2.0|
      Degeneration, Fatty, Focal           |                                           1        2                     |      2  1.5|
      Degeneration, Fatty, Multifocal      | 2                                   2  3                                 |      7  2.0|
      Hyperplasia, Focal                   |                                  1                             1         |      4  1.0|
      Hyperplasia, Multifocal              |                                                                          |      1  2.0|
      Hypertrophy, Focal                   |                         3                                                |      1  3.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Hyperplasia, Focal                   |          2     3                    1                                    |      4  2.0|
      Hyperplasia, Multifocal              |       1                       1  1        1        2  2     4     2      |     13  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Focal                   |                                                                          |      2  3.0|
      Hyperplasia                          |                                                             2            |      1  2.0|
      Hyperplasia, Multifocal              |                   3                          3                           |      3  3.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +|  43        |
      Hyperplasia, Diffuse                 |                                                                         4|      1  4.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|  48        |
      Fibrosis, Focal                      |                         3                                                |      1  3.0|
      Necrosis, Subacute                   |                                                                          |      1  4.0|
      Pars Distalis, Angiectasis           |                            2                                             |      1  2.0|
      Pars Distalis, Cyst                  |                                                                          |      1  2.0|
      Pars Distalis, Cyst, Multiple        |       2                                               4                  |      2  3.0|
      Pars Distalis, Hyperplasia, Focal    |             1                          2                          2  2   |      6  1.8|
      Pars Distalis, Hyperplasia,          |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  65                                                               
NTP Experiment-Test: 05072-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:30:54  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 6| 6| 5| 6| 6| 4| 5| 6| 6| 6| 6| 7| 5| 5| 7| 6| 6| 7| 6| 6| 6| 5| 5|            |
                             DAY ON TEST   | 6| 0| 7| 3| 1| 1| 1| 9| 7| 5| 9| 7| 5| 2| 3| 2| 2| 9| 3| 1| 0| 0| 0| 4| 4|            |
                                           | 2| 6| 3| 2| 8| 0| 8| 7| 6| 3| 8| 4| 3| 8| 2| 1| 8| 6| 8| 0| 4| 5| 1| 8| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    5 PPM                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
          Multifocal                       |                                                                          |      1  2.0|
      Pars Distalis, Hypertrophy, Focal    |                                                                          |      1  2.0|
      Pars Intermedia, Angiectasis,        |                                                                          |            |
          Multifocal                       |                                                                   2      |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      C-Cell, Hyperplasia, Focal           |                                                    2              1      |      5  1.8|
      C-Cell, Hyperplasia, Multifocal      |                                                             2            |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                    +                     |   2        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Abscess                              |                                                                          |      1  3.0|
      Atrophy                              |                                                                          |      1  3.0|
      Cyst                                 |                                                 2                        |      1  2.0|
      Ectasia                              |    3           3                    4           2              4         |      7  3.3|
      Hyperplasia                          |                                                                3        2|      2  2.5|
      Inflammation, Granulomatous          | 2  2  1  3     2  2  1  1  2           2     3  2     2  2           2   |     30  2.1|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|  46        |
      Abscess                              |                4                                                         |      1  4.0|
      Ectasia, Focal                       |                                                       2                  |      1  2.0|
      Hyperplasia, Focal                   |                                                                          |      3  1.3|
      Hyperplasia, Multifocal              |                                                                          |      2  2.0|
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|  49        |
      Atrophy                              |                               2                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mineralization, Focal                |                                                                          |      1  2.0|
      Mineralization, Multifocal           |                                                                          |      1  2.0|
      Artery, Inflammation, Chronic        |                                                                         3|      1  3.0|
      Interstitial Cell, Hyperplasia       |    1  2  2  2     1  2  1     2  2                 2                     |     21  1.8|
      Seminiferous Tubule, Atrophy         |          1              2  2  4        3              3        2         |     12  2.8|
      Seminiferous Tubule, Degeneration    |       2                                                                  |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  66                                                               
NTP Experiment-Test: 05072-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:30:54  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 6| 6| 5| 6| 6| 4| 5| 6| 6| 6| 6| 7| 5| 5| 7| 6| 6| 7| 6| 6| 6| 5| 5|            |
                             DAY ON TEST   | 6| 0| 7| 3| 1| 1| 1| 9| 7| 5| 9| 7| 5| 2| 3| 2| 2| 9| 3| 1| 0| 0| 0| 4| 4|            |
                                           | 2| 6| 3| 2| 8| 0| 8| 7| 6| 3| 8| 4| 3| 8| 2| 1| 8| 6| 8| 0| 4| 5| 1| 8| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    5 PPM                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia                          |                                                    3  3                  |      6  2.7|
      Myeloid Cell, Hyperplasia            |             4                                                            |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mediastinal, Cyst                    |             2                          4                                 |      3  3.3|
      Mediastinal, Cyst, Multiple          |    X              3     2                                                |      4  2.7|
      Mediastinal, Hemorrhage, Acute       |          2                                         3     3               |      5  2.6|
      Mediastinal, Hemorrhage, Subacute    |    2                       3                                             |      4  2.3|
      Mediastinal, Hyperplasia             |                                                                          |      1  3.0|
      Mediastinal, Pigmentation            |                                     2                    3               |      2  2.5|
      Pancreatic, Hemorrhage, Acute        |                                                                          |      1  2.0|
      Pancreatic, Hyperplasia              |                                                                          |      1  3.0|
      Renal, Hemorrhage, Acute             |             2                                                            |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Hemorrhage, Acute                    |                                                       2           4      |      2  3.0|
      Hemorrhage, Subacute                 |                         2                                                |      1  2.0|
      Hyperplasia                          |                                                                2         |      1  2.0|
      Hyperplasia, Plasma Cell             |    2                                3  2           2                     |      4  2.3|
      Inflammation, Chronic Active         |                               2                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Cyst                                 |                                        1                                 |      1  1.0|
      Hemorrhage, Acute                    |                                        2                 1               |      6  1.8|
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
      Hyperplasia, Re Cell                 |                                                                         3|      2  3.0|
      Inflammation, Subacute               |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion, Acute                    |                                                                          |      1  4.0|
      Depletion Lymphoid                   |                                                                          |      1  2.0|
      Fibrosis, Diffuse                    |                                                                          |      1  4.0|
      Fibrosis, Focal                      |                                                                          |      1  3.0|
      Hematopoietic Cell Proliferation     |       2                                2                             1   |      7  1.9|
      Necrosis, Multifocal, Subacute       |                                                                   3      |      1  3.0|
      Pigmentation, Hemosiderin            | 1                                                                        |      1  1.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  M  +  +  +|  43        |
      Ectopic Parathyroid Gland            |    X  X                                                                  |      2     |
      Epithelial Cell, Hyperplasia         |             2                                                            |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Ectasia, Diffuse                     |                                                                3         |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  67                                                               
NTP Experiment-Test: 05072-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:30:54  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 6| 6| 5| 6| 6| 4| 5| 6| 6| 6| 6| 7| 5| 5| 7| 6| 6| 7| 6| 6| 6| 5| 5|            |
                             DAY ON TEST   | 6| 0| 7| 3| 1| 1| 1| 9| 7| 5| 9| 7| 5| 2| 3| 2| 2| 9| 3| 1| 0| 0| 0| 4| 4|            |
                                           | 2| 6| 3| 2| 8| 0| 8| 7| 6| 3| 8| 4| 3| 8| 2| 1| 8| 6| 8| 0| 4| 5| 1| 8| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    5 PPM                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Ectasia, Multifocal                  |                2  3           2                 3                       4|      8  2.6|
      Hyperplasia, Diffuse                 |                               2           2                          1   |      5  1.8|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst Dermoid                         |                               X        X                                 |      2     |
      Inflammation, Chronic Active, Focal, |                                                                          |            |
           Suppurative                     |                                        3                                 |      1  3.0|
      Tail, Inflammation, Chronic          |                                                                          |      1  3.0|
      Tail, Epithelium, Hyperplasia        |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Fibrous Osteodystrophy               |                                                                         3|      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression                          |                X                                         X               |      3     |
      Hemorrhage, Multifocal               |                                     4     3  4              2            |      4  3.3|
      Hydrocephalus                        |                2                                                         |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Acute                  |                                                 2                        |      1  2.0|
      Inflammation, Chronic                |                                                                      2   |      2  2.0|
      Inflammation, Chronic Active         |                               3     1     2                 1            |      4  1.8|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Abscess                              |                            3                                             |      1  3.0|
      Hemorrhage, Acute, Focal             |                                                                         3|      1  3.0|
      Hemorrhage, Acute, Multifocal        |                                                                          |      1  2.0|
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Histiocyte                      |                                              3                           |      1  3.0|
      Necrosis, Acute, Multifocal          |                                                                          |      1  4.0|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Multifocal                      | 4  4  4  4  4  3  4  4  4  4  3  4  4  4  4  4  4  4  4  4  4  4  4  4  4|     50  3.8|
      Artery, Mediastinum, Mineralization  |                                                                         3|      1  3.0|
      Bronchiole, Hyperplasia, Multifocal  | 4  4  4  4  4     4  4  4  4  3  4     4  4  4  4  4  4  4  4  4  4  4  4|     45  3.9|
      Bronchus, Metaplasia, Squamous       |                                                                          |      1  2.0|
      Interstitium, Inflammation, Chronic, |                                                                          |            |
           Multifocal                      |                                                                         3|      1  3.0|
      Interstitium, Mineralization,        |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  68                                                               
NTP Experiment-Test: 05072-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:30:54  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 6| 6| 5| 6| 6| 4| 5| 6| 6| 6| 6| 7| 5| 5| 7| 6| 6| 7| 6| 6| 6| 5| 5|            |
                             DAY ON TEST   | 6| 0| 7| 3| 1| 1| 1| 9| 7| 5| 9| 7| 5| 2| 3| 2| 2| 9| 3| 1| 0| 0| 0| 4| 4|            |
                                           | 2| 6| 3| 2| 8| 0| 8| 7| 6| 3| 8| 4| 3| 8| 2| 1| 8| 6| 8| 0| 4| 5| 1| 8| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    5 PPM                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
          Multifocal                       |                                                                         3|      1  3.0|
      Mediastinum, Angiectasis             |                         3                                                |      1  3.0|
      Mediastinum, Cyst                    |                                                                          |      1  4.0|
      Mediastinum, Pigmentation            |                                                          3               |      1  3.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Foreign Body                         |                                                                      1   |      3  1.7|
      Lumen, Exudate                       | 2                                                                        |      1  2.0|
      Mucosa, Inflammation, Chronic Active |                1        2        2     1  2           2  4  1           2|     16  1.6|
      Mucosa, Inflammation, Chronic Active,|                                                                          |            |
           Suppurative                     |       3     2        2     4  3                    2           4  2  4   |     21  2.7|
      Mucosa, Thrombosis, Multifocal       |                            3                                      4      |      3  3.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Chronic                         |                                                                          |      1  1.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Chronic Active                  |                               1                                3         |      2  2.0|
      Olfactory Epithelium, Atrophy        |                                                                          |      3  1.7|
      Respiratory Epithelium, Hyperplasia  | 2     3     1        1  2  1  2  2        2        1  2  1           2  1|     29  1.6|
      Respiratory Epithelium, Metaplasia,  |                                                                          |            |
           Squamous                        |    2  2                    1  2  2                                   2   |     13  1.9|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                    +                     |   1        |
      Bilateral, External Ear,             |                                                                          |            |
          Hyperkeratosis                   |                                                    3                     |      1  3.0|
                                            __________________________________________________________________________|____________|
   Eye                                     |                                              +           +     +         |   4        |
      Lens, Cataract                       |                                                          4     4         |      2  4.0|
      Retina, Degeneration                 |                                                          4     3         |      2  3.5|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
      Inflammation, Chronic Active         |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst, Two                            |                                                                          |      1  3.0|
      Infarct                              |                                                                   2      |      1  2.0|
      Nephropathy, Chronic                 | 1  1  3  4  2  3  2  2  2  2  3  4  3  3  2  1  4  2  3  3  2  2  3  1  4|     49  2.5|
      Pigmentation, Diffuse                |                                     3                             2      |      3  3.0|
      Pigmentation, Multifocal             |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  69                                                               
NTP Experiment-Test: 05072-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:30:54  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 6| 6| 5| 6| 6| 4| 5| 6| 6| 6| 6| 7| 5| 5| 7| 6| 6| 7| 6| 6| 6| 5| 5|            |
                             DAY ON TEST   | 6| 0| 7| 3| 1| 1| 1| 9| 7| 5| 9| 7| 5| 2| 3| 2| 2| 9| 3| 1| 0| 0| 0| 4| 4|            |
                                           | 2| 6| 3| 2| 8| 0| 8| 7| 6| 3| 8| 4| 3| 8| 2| 1| 8| 6| 8| 0| 4| 5| 1| 8| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    5 PPM                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Cortex, Renal Tubule, Hyperplasia,   |                                                                          |            |
           Atypical, Focal                 |       3                                                                  |      1  3.0|
      Proximal Convoluted Renal Tubule,    |                                                                          |            |
           Necrosis, Acute                 |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Ureter                                  |                                                       +                  |   1        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Inflammation, Chronic Active         |                               2                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  70                                                               
NTP Experiment-Test: 05072-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:30:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 5| 4| 7| 6| 7| 5| 7| 6| 7| 6| 6| 6| 6| 5| 7| 6| 7| 5| 6| 5| 6| 6|             
                             DAY ON TEST   | 8| 2| 2| 5| 8| 2| 8| 2| 6| 2| 9| 2| 8| 7| 1| 0| 9| 2| 3| 0| 4| 5| 4| 3| 6|             
                                           | 7| 7| 7| 6| 6| 7| 7| 7| 0| 7| 2| 8| 8| 5| 9| 5| 8| 8| 3| 8| 7| 9| 1| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    2 PPM                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                              X                          X|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Parasite Metazoan                    |       X                                                                  |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Peyer's Patch, Hyperplasia           |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mucosa, Inflammation, Acute,         |                                                                          |             
          Necrotizing                      |                                              2                           |             
      Muscularis, Hyperplasia, Focal       | 4                                                                        |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  A  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Diverticulum                         |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis, Focal                   |                                                                      3   |             
      Angiectasis, Multifocal              |                   3                                                      |             
      Basophilic Focus                     |                         X                                                |             
      Basophilic Focus, Multiple           |       X                                                                  |             
      Basophilic Focus, Two                |                                  X                 X                     |             
      Cytoplasmic Alteration, Focal        |                                                                          |             
      Degeneration, Ballooning, Focal      |                                                                          |             
      Degeneration, Ballooning, Multifocal |                               3                                          |             
      Eosinophilic Focus                   |                                              X                           |             
      Fatty Change, Diffuse                |                                              2                           |             
      Fatty Change, Multifocal             |                         2                                      1        1|             
      Granuloma, Multifocal                |    1           2                                                         |             
      Hemorrhage, Acute, Multifocal        |                                     2                                    |             
      Hyperplasia, Multifocal, Nodular     | 3                                                                        |             
      Inflammation, Multifocal, Subacute   |                                                                          |             
      Mitotic Alteration                   |                                                                          |             
      Necrosis, Acute, Focal               |                                                                          |             
      Necrosis, Acute, Multifocal          |             2  1                                         4              2|             
      Necrosis, Multifocal, Subacute       | 4                             2                                          |             
      Vacuolization Cytoplasmic, Diffuse   |                                           2                              |             
      Bile Duct, Hyperplasia, Multifocal   | 3  1     3  3     3  3     2     1  4  3        1  1     3  3     1  2   |             
      Centrilobular, Atrophy, Diffuse      |                                                                          |             
      Centrilobular, Atrophy, Multifocal   |                                     3  3                                 |             
      Centrilobular, Congestion            |                4                                                         |             
      Centrilobular, Fatty Change, Diffuse |                                        4                    4            |             
      Centrilobular, Necrosis, Diffuse     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  71                                                               
NTP Experiment-Test: 05072-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:30:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 5| 4| 7| 6| 7| 5| 7| 6| 7| 6| 6| 6| 6| 5| 7| 6| 7| 5| 6| 5| 6| 6|             
                             DAY ON TEST   | 8| 2| 2| 5| 8| 2| 8| 2| 6| 2| 9| 2| 8| 7| 1| 0| 9| 2| 3| 0| 4| 5| 4| 3| 6|             
                                           | 7| 7| 7| 6| 6| 7| 7| 7| 0| 7| 2| 8| 8| 5| 9| 5| 8| 8| 3| 8| 7| 9| 1| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    2 PPM                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Centrilobular, Necrosis, Multifocal  |                                                       2                  |             
      Median Lobe, Hepatodiaphragmatic     |                                                                          |             
          Nodule                           |                                                                          |             
      Portal, Fibrosis, Multifocal         | 3                                                                        |             
                                            __________________________________________________________________________|             
   Mesentery                               |             +           +              +        +                        |             
      Accessory Spleen                     |             X                                                            |             
      Artery, Adventitia, Inflammation,    |                                                                          |             
           Chronic Active, Multifocal      |                                                                          |             
      Fat, Necrosis, Focal                 |                                                 4                        |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Focal                  |                                                                         3|             
      Acinus, Atrophy, Diffuse             |                                                                          |             
      Acinus, Atrophy, Focal               |                                                       1                  |             
      Acinus, Atrophy, Multifocal          |          2                 2     2  3        1                    3  2  3|             
      Acinus, Hyperplasia, Focal           |                                                                          |             
      Artery, Adventitia, Inflammation,    |                                                                          |             
           Chronic Active, Multifocal      |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                               2                                          |             
      Hemorrhage, Multifocal               |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         |                               2        2                    3  2     3   |             
      Ulcer                                |                                        2                                 |             
      Epithelium, Hyperplasia, Diffuse     |                                                                          |             
      Epithelium, Hyperplasia, Focal       |                               3                             3        3   |             
      Epithelium, Hyperplasia, Multifocal  |                                              2                           |             
      Mucosa, Mineralization, Multifocal   |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                              2                           |             
      Mucosa, Mineralization               |                      3                                               3   |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                      +                                                   |             
      Aorta, Mineralization, Multifocal    |                                                                          |             
      Artery, Aneurysm                     |                                                                          |             
      Artery, Arteriosclerosis, Multifocal |                      3                                                   |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 2  3  2     4  4  2  4  1  3  3  2  2  1  3     3  2  1  4     1  2  3  4|             
      Dilatation                           |                                           2                              |             
      Atrium Left, Thrombosis              |                                        4                    4            |             
      Atrium Right, Dilatation             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  72                                                               
NTP Experiment-Test: 05072-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:30:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 5| 4| 7| 6| 7| 5| 7| 6| 7| 6| 6| 6| 6| 5| 7| 6| 7| 5| 6| 5| 6| 6|             
                             DAY ON TEST   | 8| 2| 2| 5| 8| 2| 8| 2| 6| 2| 9| 2| 8| 7| 1| 0| 9| 2| 3| 0| 4| 5| 4| 3| 6|             
                                           | 7| 7| 7| 6| 6| 7| 7| 7| 0| 7| 2| 8| 8| 5| 9| 5| 8| 8| 3| 8| 7| 9| 1| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    2 PPM                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Mitral Valve, Thrombosis             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Capsule, Accessory Adrenal Cortical  |                                                                          |             
          Nodule                           |                                                                      X   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis, Multifocal              |                                                                         3|             
      Congestion                           |                                                                          |             
      Degeneration, Diffuse, Fatty         |                               2        1                       3  1  2   |             
      Degeneration, Fatty, Focal           |                                           1  2                           |             
      Degeneration, Fatty, Multifocal      |                   3                                                      |             
      Hemorrhage, Acute, Multifocal        |                                                                          |             
      Hyperplasia, Focal                   |    1                                                                    3|             
      Hyperplasia, Multifocal              |                                  2                                       |             
      Hypertrophy, Focal                   |                                                                          |             
      Necrosis, Acute, Focal               |                                                       1                  |             
      Necrosis, Acute, Multifocal          |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +     +  +  +|             
      Hyperplasia, Focal                   | 1                             2     2                                2   |             
      Hyperplasia, Multifocal              |                      3     2                                            2|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |    4  2                                                                  |             
      Hyperplasia, Multifocal              |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Diffuse                 |                      4                                               3   |             
      Hyperplasia, Focal                   |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                            3     2                                       |             
      Pars Distalis, Cyst                  |                                                          4               |             
      Pars Distalis, Cyst, Multiple        |                                                                          |             
      Pars Distalis, Developmental         |                                                                          |             
          Malformation                     |                                                                          |             
      Pars Distalis, Hyperplasia, Focal    |          2                                         4                     |             
      Pars Distalis, Hyperplasia           |                                                                          |             
      Pars Distalis, Hypertrophy, Focal    |             1                                                            |             
      Pars Distalis, Hypertrophy,          |                                                                          |             
          Multifocal                       |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia, Focal           |    4  1                                                                  |             
      C-Cell, Hyperplasia, Multifocal      |                1              1                          1               |             
      Follicle, Cyst                       |                                                                          |             
      Follicle, Cyst, Multiple             |                            2                                             |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  73                                                               
NTP Experiment-Test: 05072-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:30:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 5| 4| 7| 6| 7| 5| 7| 6| 7| 6| 6| 6| 6| 5| 7| 6| 7| 5| 6| 5| 6| 6|             
                             DAY ON TEST   | 8| 2| 2| 5| 8| 2| 8| 2| 6| 2| 9| 2| 8| 7| 1| 0| 9| 2| 3| 0| 4| 5| 4| 3| 6|             
                                           | 7| 7| 7| 6| 6| 7| 7| 7| 0| 7| 2| 8| 8| 5| 9| 5| 8| 8| 3| 8| 7| 9| 1| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    2 PPM                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM - cont                |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                +         |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       |                                     +                                    |             
      Abscess, Chronic, Multiple           |                                     3                                    |             
      Hyperplasia                          |                                     3                                    |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                         3                                                |             
      Foreign Body                         |    1           1                                                         |             
      Hyperplasia                          |                                                                          |             
      Hyperplasia, Squamous                |                         3                                                |             
      Inflammation, Granulomatous          | 3  3  1     2  1  2  2        1  3  2  3           2        2  4        2|             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                     4                                4   |             
      Hyperplasia, Focal                   |                                                                          |             
      Hyperplasia, Multifocal              |                         1                                                |             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation, Chronic Active,        |                                                                          |             
          Suppurative                      |                                                       4                  |             
      Mineralization, Multifocal           |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Atrophy                              | 2  2  3                                                                  |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization, Focal                | 3                                                                        |             
      Mineralization, Multifocal           |                                     1                          2         |             
      Artery, Inflammation, Chronic        |                                                                          |             
      Artery, Inflammation, Chronic Active,|                                                                          |             
           Multifocal                      |                                                                          |             
      Interstitial Cell, Hyperplasia       |          2              1  2        2                          1     2   |             
      Seminiferous Tubule, Atrophy         | 2                    3     2     4  1                    2               |             
      Seminiferous Tubule, Degeneration    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 3           3     3     2        2              2        2           3   |             
      Myelofibrosis, Focal                 |                                        2                                 |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inguinal, Hemorrhage, Acute          |                                                                          |             
      Mediastinal, Hemorrhage, Acute       |                   3  2                    3     2              4         |             
      Mediastinal, Hemorrhage, Subacute    |                                                                          |             
      Pancreatic, Granuloma, Multifocal    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  74                                                               
NTP Experiment-Test: 05072-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:30:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 5| 4| 7| 6| 7| 5| 7| 6| 7| 6| 6| 6| 6| 5| 7| 6| 7| 5| 6| 5| 6| 6|             
                             DAY ON TEST   | 8| 2| 2| 5| 8| 2| 8| 2| 6| 2| 9| 2| 8| 7| 1| 0| 9| 2| 3| 0| 4| 5| 4| 3| 6|             
                                           | 7| 7| 7| 6| 6| 7| 7| 7| 0| 7| 2| 8| 8| 5| 9| 5| 8| 8| 3| 8| 7| 9| 1| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    2 PPM                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage, Acute                    |                                           1                              |             
      Hyperplasia                          |                                                                          |             
      Hyperplasia, Plasma Cell             |                                     2                                    |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Hemorrhage, Acute                    |                      4                                         3     2   |             
      Hemorrhage, Subacute                 |                                                                          |             
      Hyperplasia                          |                                                                          |             
      Hyperplasia, Re Cell                 |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Depletion Lymphoid                   |                                                                          |             
      Fibrosis, Diffuse                    |                                                                          |             
      Fibrosis, Focal                      | 4                                                     4  3           4   |             
      Fibrosis                             |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                2         |             
      Hemorrhage                           |                                                                          |             
      Infarct                              |                                                                          |             
      Capsule, Fibrosis, Multifocal        |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  M  +  +  M  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +|             
      Atrophy                              |                               4                                          |             
      Ectopic Parathyroid Gland            |                                                                          |             
      Hemorrhage, Acute                    |                                     1                             2      |             
      Epithelial Cell, Hyperplasia         | 4     2                                                                  |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Ectasia, Diffuse                     |                                                             2            |             
      Ectasia, Multifocal                  | 1              3                    2  2  2                          4   |             
      Hyperplasia, Diffuse                 |          2                                                               |             
      Artery, Adventitia, Inflammation,    |                                                                          |             
           Chronic Active, Focal           |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Dermoid                         |                               X                 X                        |             
      Forelimb, Right, Hemorrhage, Chronic,|                                                                          |             
           Focal, Subacute                 |                                                                          |             
      Subcutaneous Tissue, Developmental   |                                                                          |             
          Malformation                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |                      1                                               2   |             
      Hyperostosis, Focal                  |             3                                                            |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  75                                                               
NTP Experiment-Test: 05072-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:30:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 5| 4| 7| 6| 7| 5| 7| 6| 7| 6| 6| 6| 6| 5| 7| 6| 7| 5| 6| 5| 6| 6|             
                             DAY ON TEST   | 8| 2| 2| 5| 8| 2| 8| 2| 6| 2| 9| 2| 8| 7| 1| 0| 9| 2| 3| 0| 4| 5| 4| 3| 6|             
                                           | 7| 7| 7| 6| 6| 7| 7| 7| 0| 7| 2| 8| 8| 5| 9| 5| 8| 8| 3| 8| 7| 9| 1| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    2 PPM                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                X  X                       X  X  X                        |             
      Hemorrhage, Multifocal               |                                                                          |             
      Hydrocephalus                        |                1                             2                           |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                                                          |             
      Inflammation, Chronic                | 2           1                                                     2      |             
      Inflammation, Chronic Active         |                                     1                          2         |             
      Epithelium, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Giant Cell, Multifocal               |                                                                          |             
      Hemorrhage, Acute, Multifocal        |                      4                                                   |             
      Hemorrhage, Multifocal, Subacute     |                                                                          |             
      Infiltration Cellular, Focal,        |                                                                          |             
          Histiocyte                       |                                                                          |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Histiocyte                      |                                                                          |             
      Pigmentation, Diffuse, Hemosiderin   |                                                                          |             
      Pigmentation, Hemosiderin, Multifocal|                                           2                              |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           | 3                 3                    4                                 |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Multifocal                      |    2  4        2     4  2  4  3  4  2        2  3  4  4  4     3  3  3  4|             
      Artery, Thrombosis                   |                                                                          |             
      Artery, Adventitia, Mediastinum,     |                                                                          |             
           Inflammation, Chronic Active,   |                                                                          |             
           Multifocal                      |                                                                          |             
      Bronchiole, Hyperplasia, Focal       |                                                                          |             
      Bronchiole, Hyperplasia, Multifocal  |    2  4                    4  3  4                 4  4              3   |             
      Bronchiole, Metaplasia, Focal,       |                                                                          |             
          Squamous                         |                                                                          |             
      Bronchus, Hyperplasia, Focal         |                                           4                              |             
      Interstitium, Fibrosis, Multifocal   |                                                                          |             
      Interstitium, Inflammation, Chronic, |                                                                          |             
           Diffuse                         |                                                                          |             
      Interstitium, Inflammation, Chronic  |                                                                          |             
          Active, Diffuse                  |                                           3                              |             
      Interstitium, Mineralization,        |                                                                          |             
          Multifocal                       |                      3                                                   |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                      2              2                          3        1|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  76                                                               
NTP Experiment-Test: 05072-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:30:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 5| 4| 7| 6| 7| 5| 7| 6| 7| 6| 6| 6| 6| 5| 7| 6| 7| 5| 6| 5| 6| 6|             
                             DAY ON TEST   | 8| 2| 2| 5| 8| 2| 8| 2| 6| 2| 9| 2| 8| 7| 1| 0| 9| 2| 3| 0| 4| 5| 4| 3| 6|             
                                           | 7| 7| 7| 6| 6| 7| 7| 7| 0| 7| 2| 8| 8| 5| 9| 5| 8| 8| 3| 8| 7| 9| 1| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    2 PPM                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Mucosa, Inflammation, Acute          |                                                                          |             
      Mucosa, Inflammation, Chronic Active |                      1     2     2  3        2                    1     2|             
      Mucosa, Inflammation, Chronic Active,|                                                                          |             
           Suppurative                     |                                        1                       2         |             
      Mucosa, Thrombosis, Multifocal       |                                        2                                 |             
      Nasolacrimal Duct, Exudate           |                                                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Acute, Suppurative              |                                                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Chronic                         |          2                                                     2         |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Chronic Active                  |                               3                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Chronic Active, Suppurative     | 3                                                                        |             
      Respiratory Epithelium, Hyperplasia  |                      1        1     3  1     1                 2     1  2|             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |    2                                                                     |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                 +                 A      |             
      Lens, Cataract                       |                                                 4                        |             
      Retina, Degeneration                 |                                                 4                        |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                   +      |             
      Inflammation, Chronic                |                                                                   2      |             
                                            __________________________________________________________________________|             
   Lacrimal Gland                          |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydronephrosis                       |                                                          2               |             
      Infarct                              |                                                                          |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |                            3                                             |             
      Nephropathy, Chronic                 | 3  3  3        3  4  4  2  4  3  4  4  3  3  4  1  4  2  4  3  4  2  4  4|             
      Pigmentation, Diffuse                |                                        4              3     3            |             
      Pigmentation, Multifocal             | 2                                                                        |             
      Artery, Thrombosis                   |             2                                                            |             
      Cortex, Cyst, Multiple               |                      3                       X                           |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                     3                                    |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  77                                                               
NTP Experiment-Test: 05072-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:30:54  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 6| 6| 7| 7| 6| 7| 6| 6| 7| 7| 7| 5| 7| 7| 3| 7| 5| 5| 6| 6| 7|            |
                             DAY ON TEST   | 2| 3| 2| 2| 7| 7| 0| 2| 9| 2| 6| 8| 2| 2| 2| 9| 2| 2| 5| 2| 3| 3| 1| 7| 2|            |
                                           | 8| 5| 8| 8| 5| 4| 7| 8| 9| 6| 1| 1| 9| 9| 9| 1| 9| 9| 3| 9| 5| 3| 9| 5| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    2 PPM                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|  49        |
      Parasite Metazoan                    |                                                                          |      2     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +  +  +|  47        |
      Parasite Metazoan                    | X              X                                                         |      3     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|  48        |
      Parasite Metazoan                    |       X                                X                 X               |      3     |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Peyer's Patch, Hyperplasia           |       3                                                                  |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|  49        |
      Mucosa, Inflammation, Acute,         |                                                                          |            |
          Necrotizing                      |                                                                          |      1  2.0|
      Muscularis, Hyperplasia, Focal       |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  A  A  +  A  +  +  +  +  +  +  A  +  +  A  +  +  +|  42        |
      Diverticulum                         |                                                                   2      |      1  2.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis, Focal                   |                                     3                    2               |      3  2.7|
      Angiectasis, Multifocal              |          3                                                               |      2  3.0|
      Basophilic Focus                     |                                                                          |      1     |
      Basophilic Focus, Multiple           |       X  X  X                                                  X         |      5     |
      Basophilic Focus, Two                |                                     X     X              X               |      5     |
      Cytoplasmic Alteration, Focal        |                3                    3                                    |      2  3.0|
      Degeneration, Ballooning, Focal      |                            2                                             |      1  2.0|
      Degeneration, Ballooning, Multifocal |                                                 3                        |      2  3.0|
      Eosinophilic Focus                   |       X                                                                  |      2     |
      Fatty Change, Diffuse                |                                                                          |      1  2.0|
      Fatty Change, Multifocal             |                                                             1            |      4  1.3|
      Granuloma, Multifocal                |                                           1                          2   |      4  1.5|
      Hemorrhage, Acute, Multifocal        |                   4                                                      |      2  3.0|
      Hyperplasia, Multifocal, Nodular     |                   3                                                      |      2  3.0|
      Inflammation, Multifocal, Subacute   |                                                                2         |      1  2.0|
      Mitotic Alteration                   |                                                 3                        |      1  3.0|
      Necrosis, Acute, Focal               |                                                 2                        |      1  2.0|
      Necrosis, Acute, Multifocal          |                2                                                         |      5  2.2|
      Necrosis, Multifocal, Subacute       |                   3        3                                             |      4  3.0|
      Vacuolization Cytoplasmic, Diffuse   |                                                                          |      1  2.0|
      Bile Duct, Hyperplasia, Multifocal   | 1     1        3  3  3        1     3  1  1     1           1     2  1  3|     30  2.1|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  78                                                               
NTP Experiment-Test: 05072-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:30:54  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 6| 6| 7| 7| 6| 7| 6| 6| 7| 7| 7| 5| 7| 7| 3| 7| 5| 5| 6| 6| 7|            |
                             DAY ON TEST   | 2| 3| 2| 2| 7| 7| 0| 2| 9| 2| 6| 8| 2| 2| 2| 9| 2| 2| 5| 2| 3| 3| 1| 7| 2|            |
                                           | 8| 5| 8| 8| 5| 4| 7| 8| 9| 6| 1| 1| 9| 9| 9| 1| 9| 9| 3| 9| 5| 3| 9| 5| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    2 PPM                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Centrilobular, Atrophy, Diffuse      |                                              3                           |      1  3.0|
      Centrilobular, Atrophy, Multifocal   |                                                                         4|      3  3.3|
      Centrilobular, Congestion            |                                                                          |      1  4.0|
      Centrilobular, Fatty Change, Diffuse |                                                                          |      2  4.0|
      Centrilobular, Necrosis, Diffuse     |                                  3                                       |      1  3.0|
      Centrilobular, Necrosis, Multifocal  |                         4                                                |      2  3.0|
      Median Lobe, Hepatodiaphragmatic     |                                                                          |            |
          Nodule                           |                   X                                                      |      1     |
      Portal, Fibrosis, Multifocal         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |             +                    +     +                                 |   7        |
      Accessory Spleen                     |                                                                          |      1     |
      Artery, Adventitia, Inflammation,    |                                                                          |            |
           Chronic Active, Multifocal      |             4                                                            |      1  4.0|
      Fat, Necrosis, Focal                 |                                        3                                 |      2  3.5|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|  48        |
      Inflammation, Focal                  |                                                                          |      1  3.0|
      Acinus, Atrophy, Diffuse             |                                           4     4                        |      2  4.0|
      Acinus, Atrophy, Focal               | 2                                      2                                 |      3  1.7|
      Acinus, Atrophy, Multifocal          |                               3     1              3     2               |     12  2.3|
      Acinus, Hyperplasia, Focal           |          3                    2                                          |      2  2.5|
      Artery, Adventitia, Inflammation,    |                                                                          |            |
           Chronic Active, Multifocal      |             4                                                            |      1  4.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|  49        |
      Erosion                              |                                                                          |      1  2.0|
      Hemorrhage, Multifocal               |                   3                                                      |      1  3.0|
      Inflammation, Chronic                |                   2                                                      |      1  2.0|
      Inflammation, Chronic Active         |                            4                                             |      6  2.7|
      Ulcer                                |                            4                                             |      2  3.0|
      Epithelium, Hyperplasia, Diffuse     |                   3        3                                             |      2  3.0|
      Epithelium, Hyperplasia, Focal       |                                                                          |      3  3.0|
      Epithelium, Hyperplasia, Multifocal  |                                                                          |      1  2.0|
      Mucosa, Mineralization, Multifocal   |                                                          2               |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  M  +  +  +  +  +  +  +  +     +  +  +  +  +  +  A  +  +  +  +  +  +|  47        |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Mucosa, Mineralization               |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                     +                                    |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  79                                                               
NTP Experiment-Test: 05072-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:30:54  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 6| 6| 7| 7| 6| 7| 6| 6| 7| 7| 7| 5| 7| 7| 3| 7| 5| 5| 6| 6| 7|            |
                             DAY ON TEST   | 2| 3| 2| 2| 7| 7| 0| 2| 9| 2| 6| 8| 2| 2| 2| 9| 2| 2| 5| 2| 3| 3| 1| 7| 2|            |
                                           | 8| 5| 8| 8| 5| 4| 7| 8| 9| 6| 1| 1| 9| 9| 9| 1| 9| 9| 3| 9| 5| 3| 9| 5| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    2 PPM                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |             +                                            +               |   3        |
      Aorta, Mineralization, Multifocal    |                                                          2               |      1  2.0|
      Artery, Aneurysm                     |             X                                                            |      1     |
      Artery, Arteriosclerosis, Multifocal |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       | 1  1  3  3  3     3  2  3  2  2  4  3  2  1     3  2     2  1     3  2  3|     43  2.4|
      Dilatation                           |                                                                          |      1  2.0|
      Atrium Left, Thrombosis              |                                                                   3      |      3  3.7|
      Atrium Right, Dilatation             |                            4                                             |      1  4.0|
      Mitral Valve, Thrombosis             |                   3                                                      |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Capsule, Accessory Adrenal Cortical  |                                                                          |            |
          Nodule                           |       X                       X        X                 X               |      5     |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|  49        |
      Angiectasis, Multifocal              |                                                                          |      1  3.0|
      Congestion                           |                         4                                                |      1  4.0|
      Degeneration, Diffuse, Fatty         |                   3           2  4           2     2                     |     10  2.2|
      Degeneration, Fatty, Focal           | 1                    2              4                                    |      5  2.0|
      Degeneration, Fatty, Multifocal      |       2                    2                       2                     |      4  2.3|
      Hemorrhage, Acute, Multifocal        |                   3                                                      |      1  3.0|
      Hyperplasia, Focal                   |                                                 3        2               |      4  2.3|
      Hyperplasia, Multifocal              | 2        3                 2                                         1   |      5  2.0|
      Hypertrophy, Focal                   |                                     1     1                              |      2  1.0|
      Necrosis, Acute, Focal               |                                                                          |      1  1.0|
      Necrosis, Acute, Multifocal          |                   2                                                      |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|  47        |
      Hyperplasia, Focal                   |          4           1        1     2           2                        |      9  1.9|
      Hyperplasia, Multifocal              |       2     3  2        3  2     2        1                             3|     11  2.3|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|  48        |
      Hyperplasia, Focal                   | 3        4              2              2     2                           |      7  2.7|
      Hyperplasia, Multifocal              |                                                    2                     |      1  2.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hyperplasia, Diffuse                 |                            3                             4               |      4  3.5|
      Hyperplasia, Focal                   |          3                                                               |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|  49        |
      Pars Distalis, Angiectasis           |                   4                                                      |      3  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  80                                                               
NTP Experiment-Test: 05072-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:30:54  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 6| 6| 7| 7| 6| 7| 6| 6| 7| 7| 7| 5| 7| 7| 3| 7| 5| 5| 6| 6| 7|            |
                             DAY ON TEST   | 2| 3| 2| 2| 7| 7| 0| 2| 9| 2| 6| 8| 2| 2| 2| 9| 2| 2| 5| 2| 3| 3| 1| 7| 2|            |
                                           | 8| 5| 8| 8| 5| 4| 7| 8| 9| 6| 1| 1| 9| 9| 9| 1| 9| 9| 3| 9| 5| 3| 9| 5| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    2 PPM                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Pars Distalis, Cyst                  |                   4           2                                          |      3  3.3|
      Pars Distalis, Cyst, Multiple        |                                                                         2|      1  2.0|
      Pars Distalis, Developmental         |                                                                          |            |
          Malformation                     |                            X                                             |      1     |
      Pars Distalis, Hyperplasia, Focal    |                2                                                         |      3  2.7|
      Pars Distalis, Hyperplasia           |                                  3                                       |      1  3.0|
      Pars Distalis, Hypertrophy, Focal    |                                                                          |      1  1.0|
      Pars Distalis, Hypertrophy,          |                                                                          |            |
          Multifocal                       |                                                                   2      |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|  49        |
      C-Cell, Hyperplasia, Focal           |                                                                          |      2  2.5|
      C-Cell, Hyperplasia, Multifocal      |                   1  3                    1                              |      6  1.3|
      Follicle, Cyst                       |                                                                   4      |      1  4.0|
      Follicle, Cyst, Multiple             |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Coagulating Gland                       |                                                                          |   1        |
      Abscess, Chronic, Multiple           |                                                                          |      1  3.0|
      Hyperplasia                          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  M  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Ectasia                              | 4                       3     4                                          |      4  3.5|
      Foreign Body                         |                                                                         1|      3  1.0|
      Hyperplasia                          |                      4                                                   |      1  4.0|
      Hyperplasia, Squamous                |                                                                          |      1  3.0|
      Inflammation, Granulomatous          |       2     3     1  3  3        2  2     2              3  2  1     2  3|     28  2.2|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Abscess                              |                                                                          |      2  4.0|
      Hyperplasia, Focal                   | 1                 1                    2                                 |      3  1.3|
      Hyperplasia, Multifocal              |                      2                          3  2     2               |      5  2.0|
      Inflammation, Chronic Active         |                                                                         3|      1  3.0|
      Inflammation, Chronic Active,        |                                                                          |            |
          Suppurative                      |                                                                          |      1  4.0|
      Mineralization, Multifocal           |                                  2                                       |      1  2.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|  47        |
      Atrophy                              |                                                                          |      3  2.3|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  81                                                               
NTP Experiment-Test: 05072-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:30:54  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 6| 6| 7| 7| 6| 7| 6| 6| 7| 7| 7| 5| 7| 7| 3| 7| 5| 5| 6| 6| 7|            |
                             DAY ON TEST   | 2| 3| 2| 2| 7| 7| 0| 2| 9| 2| 6| 8| 2| 2| 2| 9| 2| 2| 5| 2| 3| 3| 1| 7| 2|            |
                                           | 8| 5| 8| 8| 5| 4| 7| 8| 9| 6| 1| 1| 9| 9| 9| 1| 9| 9| 3| 9| 5| 3| 9| 5| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    2 PPM                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mineralization, Focal                |                         1                                                |      2  2.0|
      Mineralization, Multifocal           |                   2                                                      |      3  1.7|
      Artery, Inflammation, Chronic        | 2                                                                        |      1  2.0|
      Artery, Inflammation, Chronic Active,|                                                                          |            |
           Multifocal                      |             2              2                             4               |      3  2.7|
      Interstitial Cell, Hyperplasia       |       2     2  2     1  1     2              1  2           2  1         |     16  1.6|
      Seminiferous Tubule, Atrophy         | 2                 3                 3                                    |      9  2.4|
      Seminiferous Tubule, Degeneration    |                            2                                             |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                            +                                             |   1        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|  49        |
      Hyperplasia                          |    4        3     3                 2                             3      |     13  2.7|
      Myelofibrosis, Focal                 |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inguinal, Hemorrhage, Acute          |                                                                         2|      1  2.0|
      Mediastinal, Hemorrhage, Acute       |                         3  3                                             |      7  2.9|
      Mediastinal, Hemorrhage, Subacute    |                   4                       2                    3         |      3  3.0|
      Pancreatic, Granuloma, Multifocal    |                                                                      3   |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +|  44        |
      Hemorrhage, Acute                    |                                                                         2|      2  1.5|
      Hyperplasia                          |             3                    3                                       |      2  3.0|
      Hyperplasia, Plasma Cell             |                      2                                                   |      2  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|  48        |
      Hemorrhage, Acute                    |       3           2                    2                    2     2  3  3|     10  2.6|
      Hemorrhage, Subacute                 |                         2                                                |      1  2.0|
      Hyperplasia                          |                                                    2                     |      1  2.0|
      Hyperplasia, Re Cell                 |                            3                                             |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|  49        |
      Depletion Lymphoid                   |                            4                                             |      1  4.0|
      Fibrosis, Diffuse                    |                            3                                             |      1  3.0|
      Fibrosis, Focal                      |                                     4              4                     |      6  3.8|
      Fibrosis                             |                         4                                                |      1  4.0|
      Hematopoietic Cell Proliferation     |    2              4                                            3         |      4  2.8|
      Hemorrhage                           |                         4                                                |      1  4.0|
      Infarct                              |                                              2                           |      1  2.0|
      Capsule, Fibrosis, Multifocal        |                                                                   3      |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +     +  +  +  M  +  +|  42        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  82                                                               
NTP Experiment-Test: 05072-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:30:54  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 6| 6| 7| 7| 6| 7| 6| 6| 7| 7| 7| 5| 7| 7| 3| 7| 5| 5| 6| 6| 7|            |
                             DAY ON TEST   | 2| 3| 2| 2| 7| 7| 0| 2| 9| 2| 6| 8| 2| 2| 2| 9| 2| 2| 5| 2| 3| 3| 1| 7| 2|            |
                                           | 8| 5| 8| 8| 5| 4| 7| 8| 9| 6| 1| 1| 9| 9| 9| 1| 9| 9| 3| 9| 5| 3| 9| 5| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    2 PPM                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Atrophy                              |                                                                          |      1  4.0|
      Ectopic Parathyroid Gland            |             X                                            X               |      2     |
      Hemorrhage, Acute                    |                                                                          |      2  1.5|
      Epithelial Cell, Hyperplasia         |    2     4                          2                    3               |      6  2.8|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|  46        |
      Ectasia, Diffuse                     |                                                                          |      1  2.0|
      Ectasia, Multifocal                  |                   2  3                          2        4              2|     11  2.5|
      Hyperplasia, Diffuse                 | 2                                                                       2|      3  2.0|
      Artery, Adventitia, Inflammation,    |                                                                          |            |
           Chronic Active, Focal           |             2                                                            |      1  2.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|  49        |
      Cyst Dermoid                         |                                                                          |      2     |
      Forelimb, Right, Hemorrhage, Chronic,|                                                                          |            |
           Focal, Subacute                 |             4                                                            |      1  4.0|
      Subcutaneous Tissue, Developmental   |                                                                          |            |
          Malformation                     |                                                                         X|      1     |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|  49        |
      Fibrous Osteodystrophy               |                                                                          |      2  1.5|
      Hyperostosis, Focal                  |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                   +                                                      |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression                          | X                    X     X                             X              X|     10     |
      Hemorrhage, Multifocal               |                3                                                         |      1  3.0|
      Hydrocephalus                        |                      1                                                   |      3  1.3|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|  49        |
      Foreign Body                         |                                                          2               |      1  2.0|
      Inflammation, Chronic                |                                        1                                 |      4  1.5|
      Inflammation, Chronic Active         | 1        2  2  3           2                             2     2        1|     10  1.8|
      Epithelium, Hyperplasia              |             2                                                        2   |      2  2.0|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Giant Cell, Multifocal               |             3                                                            |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  83                                                               
NTP Experiment-Test: 05072-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:30:54  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 6| 6| 7| 7| 6| 7| 6| 6| 7| 7| 7| 5| 7| 7| 3| 7| 5| 5| 6| 6| 7|            |
                             DAY ON TEST   | 2| 3| 2| 2| 7| 7| 0| 2| 9| 2| 6| 8| 2| 2| 2| 9| 2| 2| 5| 2| 3| 3| 1| 7| 2|            |
                                           | 8| 5| 8| 8| 5| 4| 7| 8| 9| 6| 1| 1| 9| 9| 9| 1| 9| 9| 3| 9| 5| 3| 9| 5| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    2 PPM                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Hemorrhage, Acute, Multifocal        |                                                                   2      |      2  3.0|
      Hemorrhage, Multifocal, Subacute     |                   3                          2                           |      2  2.5|
      Infiltration Cellular, Focal,        |                                                                          |            |
          Histiocyte                       |          2                                                               |      1  2.0|
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Histiocyte                      |       2                                                                  |      1  2.0|
      Pigmentation, Diffuse, Hemosiderin   |                         2                                                |      1  2.0|
      Pigmentation, Hemosiderin, Multifocal|                   3                                                      |      2  2.5|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |             2     4                          2        2                  |      7  2.9|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Multifocal                      | 4     3  4     4     2  3  2  4  4  3  3  3     4  3     4  2     2  2  3|     37  3.1|
      Artery, Thrombosis                   |                               4                                          |      1  4.0|
      Artery, Adventitia, Mediastinum,     |                                                                          |            |
           Inflammation, Chronic Active,   |                                                                          |            |
           Multifocal                      |             4                                                            |      1  4.0|
      Bronchiole, Hyperplasia, Focal       |             2     4                                                      |      2  3.0|
      Bronchiole, Hyperplasia, Multifocal  |       3  4           2  3  2  4  4  3     3     4  3     4        2      |     21  3.3|
      Bronchiole, Metaplasia, Focal,       |                                                                          |            |
          Squamous                         |                         3                                                |      1  3.0|
      Bronchus, Hyperplasia, Focal         |                                                                          |      1  4.0|
      Interstitium, Fibrosis, Multifocal   |                4                                                         |      1  4.0|
      Interstitium, Inflammation, Chronic, |                                                                          |            |
           Diffuse                         |                         2                                                |      1  2.0|
      Interstitium, Inflammation, Chronic  |                                                                          |            |
          Active, Diffuse                  |                                                                          |      1  3.0|
      Interstitium, Mineralization,        |                                                                          |            |
          Multifocal                       |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|  49        |
      Foreign Body                         | 2                                      1     1                    2  2  2|     10  1.8|
      Mucosa, Inflammation, Acute          |                            1                                             |      1  1.0|
      Mucosa, Inflammation, Chronic Active | 1           1                          1  2              3  2     2  1  3|     16  1.8|
      Mucosa, Inflammation, Chronic Active,|                                                                          |            |
           Suppurative                     |                               1              1                           |      4  1.3|
      Mucosa, Thrombosis, Multifocal       |                   3                             3                        |      3  2.7|
      Nasolacrimal Duct, Exudate           |                   4                                                      |      1  4.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Acute, Suppurative              |                               1        2                                 |      2  1.5|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  84                                                               
NTP Experiment-Test: 05072-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 04/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:30:54  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 6| 6| 7| 7| 6| 7| 6| 6| 7| 7| 7| 5| 7| 7| 3| 7| 5| 5| 6| 6| 7|            |
                             DAY ON TEST   | 2| 3| 2| 2| 7| 7| 0| 2| 9| 2| 6| 8| 2| 2| 2| 9| 2| 2| 5| 2| 3| 3| 1| 7| 2|            |
                                           | 8| 5| 8| 8| 5| 4| 7| 8| 9| 6| 1| 1| 9| 9| 9| 1| 9| 9| 3| 9| 5| 3| 9| 5| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    2 PPM                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
           Chronic                         |    3                                                           2         |      4  2.3|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Chronic Active                  |                2                                                         |      2  2.5|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Chronic Active, Suppurative     |                                                                          |      1  3.0|
      Respiratory Epithelium, Hyperplasia  |                               1  1              1        2        1  1  2|     15  1.4|
      Respiratory Epithelium, Metaplasia,  |                                                                          |            |
           Squamous                        |                                  1                                       |      1  1.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                | 2     3                                                                  |      3  2.3|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                +     +   |   3        |
      Lens, Cataract                       |                                                                          |      1  4.0|
      Retina, Degeneration                 |                                                                      4   |      2  4.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
      Inflammation, Chronic                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lacrimal Gland                          |                                     +                                    |   1        |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          | +           +                                                            |   2        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hydronephrosis                       |                                                                          |      1  2.0|
      Infarct                              |                   3                          3                           |      2  3.0|
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |                                                                          |      1  3.0|
      Nephropathy, Chronic                 | 4  1  4  4  4  3  3  4  4  4  3  4  3  2  3  1  4  4     4  2  1  2  3  4|     47  3.2|
      Pigmentation, Diffuse                |                                                                          |      3  3.3|
      Pigmentation, Multifocal             |                   2                                               2      |      3  2.0|
      Artery, Thrombosis                   |                                                                          |      1  2.0|
      Cortex, Cyst, Multiple               |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|  49        |
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  85                                                               
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NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.